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https://www.readbyqxmd.com/read/28806750/characterization-of-novel-bangle-lectin-from-photorhabdus-asymbiotica-with-dual-sugar-binding-specificity-and-its-effect-on-host-immunity
#1
Gita Jančaříková, Josef Houser, Pavel Dobeš, Gabriel Demo, Pavel Hyršl, Michaela Wimmerová
Photorhabdus asymbiotica is one of the three recognized species of the Photorhabdus genus, which consists of gram-negative bioluminescent bacteria belonging to the family Morganellaceae. These bacteria live in a symbiotic relationship with nematodes from the genus Heterorhabditis, together forming a complex that is highly pathogenic for insects. Unlike other Photorhabdus species, which are strictly entomopathogenic, P. asymbiotica is unique in its ability to act as an emerging human pathogen. Analysis of the P...
August 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28804823/an-overview-of-thrombophilia-and-associated-laboratory-testing
#2
Martina Montagnana, Giuseppe Lippi, Elisa Danese
Venous thromboembolism, usually entailing deep vein thrombosis, pulmonary embolism, or both, is a complex and multifactorial disorder, in which a number of putative conditions interplay and finally contribute to propel the individual risk over a certain degree, so ultimately culminating in the development of venous occlusive disorders. Thrombophilia is commonly defined as a propensity to develop venous thromboembolism on the basis of an underlying hypercoagulable state attributable to inherited or acquired disorders of blood coagulation or fibrinolysis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28803481/autonomous-collision-free-navigation-of-microvehicles-in-complex-and-dynamically-changing-environments
#3
Tianlong Li, Xiaocong Chang, Zhiguang Wu, Jinxing Li, Guangbin Shao, Xinghong Deng, Jianbin Qiu, Bin Guo, Guangyu Zhang, Qiang He, Longqiu Li, Joseph Wang
Self-propelled micro- and nanoscale robots represent a rapidly emerging and fascinating robotics research area. However, designing autonomous and adaptive control systems for operating micro-/nanorobotics in complex and dynamically-changing environments, which is a highly demanding feature, is still an unmet challenge. Here we describe a smart microvehicle for precise autonomous navigation in complicated environments and traffic scenarios. The fully autonomous navigation system of the smart microvehicle is composed of a microscope-coupled CCD camera, an artificial intelligence planner, and a magnetic field generator...
August 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/28801135/pyrrolo-2-1-f-1-2-4-triazines-from-c-nucleosides-to-kinases-and-back-again-the-remarkable-journey-of-a-versatile-nitrogen-heterocycle
#4
REVIEW
Gregory R Ott, David A Favor
Pyrrolo[2,1-f][1,2,4]triazine, a unique NN bond-containing heterocycle with a bridgehead nitrogen, was first synthesized in the late 1970s but did not find utility until more than a decade later in the early 1990s when it was incorporated into C-nucleosides as a novel purine-like mimetic. This heterocycle remained at the fringes of medicinal chemistry until a confluence of events spurred by the explosion of the kinase inhibitor field in the early 2000s and the pressing need for novel, druggable scaffolds to occupy that exciting space led to numerous applications against diverse therapeutic targets...
July 30, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28799745/a-two-distinctly-separated-emission-colorimetric-nir-fluorescent-probe-for-fast-hydrazine-detection-in-living-cells-and-mice-upon-independent-excitations
#5
Zhengliang Lu, Wenlong Fan, Xiaomin Shi, Yanan Lu, Chunhua Fan
Hydrazine is carcinogenic and highly toxic so that it can lead to serious environmental contamination and serious health risks although it has been extensively used as an effective propellant and an important reactive base in industry. Thus, the development of two-emission NIR fluorescent probes for rapid detection of hydrazine with high selectivity and sensitivity is of significance and of great challenge in both biological and environmental sciences. Here, we report a two-emission colori-metric fluorescent probe for the specific detection of hydrazine based on hydrazinolysis reaction under physiological condi-tions...
August 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28798894/clients-perspectives-on-quality-of-delivery-services-in-a-rural-setting-in-tanzania-findings-from-a-qualitative-action-oriented-research
#6
Gerald J Makuka, Moses M Sango, Ayubu E Mashambo, Abednego E Mashambo, Sia E Msuya, Sabina P Mtweve
OBJECTIVE: To know and understand the perspectives of women on the quality of maternal health services provided at their health facility (HF) and to incite community self-propelled problem identification and way forward. METHODS: A qualitative action- oriented research was conducted in a rural setting in Tanzania from 2011 to 2014. Twenty In-Depth Interviews (IDIs) and two Focus Group Discussions were held. The IDIs were conducted with mothers who had attended antenatal care at the HF and delivered there...
2017: International Journal of MCH and AIDS
https://www.readbyqxmd.com/read/28797235/polymorphisms-of-plasmodium-falciparum-k13-propeller-gene-among-migrant-workers-returning-to-henan-province-china-from-africa
#7
Chengyun Yang, Hongwei Zhang, Ruimin Zhou, Dan Qian, Ying Liu, Yuling Zhao, Suhua Li, Bianli Xu
BACKGROUND: Henan Province has been in the malaria elimination stage, with all reports of the disease being imported since 2012 and over 90% coming from Africa. Surveillance and population studies are essential for the early detection and subsequent prevention of the spread of drug resistance. The K13-propeller gene was recently identified as a proposed molecular marker of artemisinin (ART) resistance. In this study, we detected mutations of the K13-propeller gene in samples taken from imported malaria cases in Henan Province from 2012 to 2015...
August 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28795477/exogenous-serotonin-regulates-colorectal-motility-via-the-5-ht2-and-5-ht3-receptors-in-the-spinal-cord-of-rats
#8
H Nakamori, K Naitou, Y Sano, H Shimaoka, T Shiina, Y Shimizu
BACKGROUND: We previously reported that intrathecal injection of noradrenaline or dopamine causes enhancement of colorectal motility. As these monoamines are neurotransmitters of descending pain inhibitory pathways in the spinal cord, we hypothesized that serotonin, which is one of the neurotransmitters involved in descending pain inhibition, also influences the lumbosacral defecation center. Therefore, we examined whether serotonin acting on the spinal defecation center enhances colorectal motility...
August 10, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28793241/the-activity-based-methodology-to-assess-ship-emissions-a-review
#9
REVIEW
R A O Nunes, M C M Alvim-Ferraz, F G Martins, S I V Sousa
Several studies tried to estimate atmospheric emissions with origin in the maritime sector, concluding that it contributed to the global anthropogenic emissions through the emission of pollutants that have a strong impact on hu' health and also on climate change. Thus, this paper aimed to review published studies since 2010 that used activity-based methodology to estimate ship emissions, to provide a summary of the available input data. After exclusions, 26 articles were analysed and the main information were scanned and registered, namely technical information about ships, ships activity and movement information, engines, fuels, load and emission factors...
August 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28790518/coordinated-management-of-academic-health-centers
#10
Jeffrey R Balser, William W Stead
Academic health centers (AHCs) are the nation's primary resource for healthcare discovery, innovation, and training. US healthcare revenue growth has declined sharply since 2009, and is forecast to remain well below historic levels for the foreseeable future. As the cost of education and research at nearly all AHCs is heavily subsidized through large transfers from clinical care margins, our institutions face a mounting crisis. Choices centering on how to increase the cost-effectiveness of the AHC enterprise require unprecedented levels of alignment to preserve an environment that nurtures creativity...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790314/structural-and-functional-insights-into-the-lipopolysaccharide-abc-transporter-lptb2fg
#11
Haohao Dong, Zhengyu Zhang, Xiaodi Tang, Neil G Paterson, Changjiang Dong
The cell surface of most Gram-negative bacteria contains lipopolysaccharide that is essential for their viability and drug resistance. A 134-kDa protein complex LptB2FG is unique among ATP-binding cassette transporters because it extracts lipopolysaccharide from the external leaflet of the inner membrane and propels it along a filament that extends across the periplasm to directly deliver lipopolysaccharide into the external leaflet of the outer membrane. Here we report the crystal structure of the lipopolysaccharide transporter LptB2FG from Klebsiella pneumoniae, in which both LptF and LptG are composed of a β-jellyroll-like periplasmic domain and six α-helical segments in the transmembrane domain...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28782428/enhanced-removal-of-heavy-metals-by-zerovalent-iron-in-designed-magnetic-reactors
#12
Peng Fan, Xiao Jiang, Junlian Qiao, Lina Li
A magnetic propeller agitator and a magnetic reactor were designed to enhance the removal of heavy metals by zerovalent iron (ZVI) in comparison with the non-magnetic reactor. The weak magnetic field (WMF) applied in the magnetic propeller agitator or the magnetic reactor significantly improved the Cu(II)-EDTA removal by ZVI from 10% without WMF to 98% with WMF within 2.5 h at pHini 6.0. Simultaneous removal of Cu(II) and As(V) by ZVI was performed in the magnetic reactor. The results show that the pseudo-first-order rate constants of Cu(II) and As(V) removal by ZVI in the magnetic reactor were increased by 1...
August 7, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28782037/chemotactic-synthetic-vesicles-design-and-applications-in-blood-brain-barrier-crossing
#13
Adrian Joseph, Claudia Contini, Denis Cecchin, Sophie Nyberg, Lorena Ruiz-Perez, Jens Gaitzsch, Gavin Fullstone, Xiaohe Tian, Juzaili Azizi, Jane Preston, Giorgio Volpe, Giuseppe Battaglia
In recent years, scientists have created artificial microscopic and nanoscopic self-propelling particles, often referred to as nano- or microswimmers, capable of mimicking biological locomotion and taxis. This active diffusion enables the engineering of complex operations that so far have not been possible at the micro- and nanoscale. One of the most promising tasks is the ability to engineer nanocarriers that can autonomously navigate within tissues and organs, accessing nearly every site of the human body guided by endogenous chemical gradients...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28777156/deep-transverse-metacarpal-ligament-reconstruction-using-suture-button-and-a1-pulley
#14
Joshua Piercey, Paul McEniery, Nicholas Green
Rupture of the deep transverse metacarpal ligament (DTML) can result in pain, impaired grip strength, and undermine functional performance of the hand. We describe the case of a patient whose right hand came into contact with a boat propeller. He sustained a complete disruption of the DTML between the second and third ray in addition to soft tissue injury and open metacarpal fractures. Although other techniques describe a reconstruction of the DTML, our technique describes an adjunctive technique that strongly augments the A1 pulley reconstruction and nullifies the requirements of palmaris longus graft...
August 3, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28774811/the-interaction-of-dendrimer-doxorubicin-conjugates-with-a-model-pulmonary-epithelium-and-their-cosolvent-free-pseudo-solution-formulations-in-pressurized-metered-dose-inhalers
#15
Qian Zhong, Bruno V Humia, Alisha R Punjabi, Francine F Padilha, Sandro R P da Rocha
Oral inhalation (OI) of nano-chemotherapeutics holds great potentials in the treatment of lung cancers as it enables direct targeting of drugs to lung tissues, spatial and temporal control of drug release, and decrease in drug-associated systemic and local lung toxicity. Therefore, the design of chemistry of the nanocarriers and their OI formulations for chemotherapeutics delivery to the peripheral lungs and extrapulmonary tissues of relevance such as lymph nodes, may thus afford new opportunities for treating such relevant diseases...
July 31, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28774809/towards-diversity-in-genomics-the-emergence-of-neurogenomics-in-africa
#16
Emmanuel Quansah, Nathaniel W McGregor
There is a high burden of mental and neurological disorders in Africa. Nevertheless, there appears to be an under-representation of African ancestry populations in large-scale genomic studies. Here, we evaluated the extent of under-representation of Africans in neurogenomic studies in the GWAS Catalog. We found 569 neurogenomic studies, of which 88.9% were exclusively focused on people with European ancestry and the remaining 11.1% having African ancestry cases included. In terms of population, only 1.2% of the total populations involved in these 569 GWAS studies were of African descent...
August 1, 2017: Genomics
https://www.readbyqxmd.com/read/28772797/special-issue-materials-for-electrochemical-capacitors-and-batteries
#17
EDITORIAL
Jian-Gan Wang, Bingqing Wei
Electrochemical capacitors and rechargeable batteries have received worldwide attention due to their excellent energy storage capability for a variety of applications. The rapid development of these technologies is propelled by the advanced electrode materials and new energy storage systems. It is believed that research efforts can improve the device performance to meet the ever-increasing requirements of high energy density, high power density and long cycle life. This Special Issue aims to provide readers with a glimpse of different kinds of electrode materials for electrochemical capacitors and batteries...
April 22, 2017: Materials
https://www.readbyqxmd.com/read/28768881/hydrodynamic-advantages-of-swimming-by-salp-chains
#18
Kelly R Sutherland, Daniel Weihs
Salps are marine invertebrates comprising multiple jet-propelled swimming units during a colonial life-cycle stage. Using theory, we show that asynchronous swimming with multiple pulsed jets yields substantial hydrodynamic benefit due to the production of steady swimming velocities, which limit drag. Laboratory comparisons of swimming kinematics of aggregate salps (Salpa fusiformis and Weelia cylindrica) using high-speed video supported that asynchronous swimming by aggregates results in a smoother velocity profile and showed that this smoother velocity profile is the result of uncoordinated, asynchronous swimming by individual zooids...
August 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28766641/complex-self-propelled-rings-a-minimal-model-for-cell-motility
#19
Clara Abaurrea Velasco, Sepehr Dehghani Ghahnaviyeh, Hossein Nejat Pishkenari, Thorsten Auth, Gerhard Gompper
Collective behavior of active matter is observed for self-propelled particles, such as vibrated disks and active Brownian particles, as well as for cytoskeletal filaments in motile cells. Here, a system of quasi two-dimensional penetrable self-propelled rods inside rigid rings is used to construct a complex self-propelled particle. The rods interact sterically with each other and with a stationary or mobile ring via a separation-shifted Lennard-Jones potential. They either have a sliding attachment to the inside of the ring at one of their ends, or can move freely within the ring confinement...
August 2, 2017: Soft Matter
https://www.readbyqxmd.com/read/28765649/hyperbolic-polaritons-enabled-dark-field-lens-for-sensitive-detection
#20
Lian Shen, Huaping Wang, Rujiang Li, Zhiwei Xu, Hongsheng Chen
Sensitive detection of features in a nanostructure may sometimes be puzzled in the presence of significant background noise. In this regard, background suppression and super-resolution are substantively important for detecting weakly scattering nanoscale features. Here, we present a lens design, termed hyperbolic-polaritons-enabled dark-field lens (HPEDL), which has the ability to accomplish straightforward sensitive detection. This HPEDL structure consists of type I and type II hyperbolic media that support high-k field waves via hyperbolic polaritons (HPs)...
August 1, 2017: Scientific Reports
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