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https://www.readbyqxmd.com/read/28930338/biomedical-nanomotors-efficient-glucose-mediated-insulin-release
#1
Paula Díez, Berta Esteban-Fernández de Ávila, Doris E Ramírez-Herrera, Reynaldo Villalonga, Joseph Wang
We report herein the design of an autonomous glucose-responsive smart nanomachine for insulin (In) delivery based on ultrasound (US)-propelled nanomotors combined with an enzyme-based sensing-effector unit. Gold nanowire (AuNW) motors have been coupled with a mesoporous silica (MS) segment, which was gated with pH-responsive phenylboronic acid (PBA)-glucose oxidase (GOx) supramolecular nanovalves responsible for the insulin release. Glucose-induced protonation of the PBA groups triggers the opening of the pH-driven gate and uncapping of the insulin-loaded nanovalves...
September 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28929766/converting-vertical-vibration-of-anisotropic-ratchet-conveyors-into-horizontal-droplet-motion
#2
Yan Dong, Hal Holmes, Karl F Böhringer
An anisotropic ratchet conveyor is an asymmetric, periodic, micropatterned surface that propels droplets when vibrated with a sinusoidal signal at certain frequencies and amplitudes. For each input frequency, there is a threshold amplitude beyond which the droplet starts to move. In this paper, we study the parameters that initiate droplet motion and the relationship between the input frequency and threshold amplitude among droplets with different volume, density, viscosity and surface tension. Through this investigation we demonstrate how non-dimensionalization reveals consistent behavior for droplets of different volumes...
September 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28929311/tbi-rehabilomics-research-an-exemplar-of-a-biomarker-based-approach-to-precision-care-for-populations-with-disability
#3
REVIEW
Amy K Wagner
PURPOSE OF REVIEW: The purpose of this review is to summarize how "-omics" technologies can inform rehabilitation-relevant outcomes for a range of populations with neurologically related disability by including outcome metrics linked to the World Health Organization's International Classification of Functioning, Disability, and Health (WHO-ICF) domains of impairments in body function, activity limitations, and participation restrictions. RECENT FINDINGS: To date, nearly every area of medicine uses biomarkers in some capacity to aid in understanding how personal biology informs clinical care...
September 19, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28925493/repair-and-sensory-reconstruction-of-the-children-s-finger-pulp-defects-with-perforator-pedicled-propeller-flap-in-proper-digital-artery
#4
S-M Feng, A-G Wang, Z-Y Zhang, Q-Q Sun, Y-L Tao, M-M Zhou, Y-J Hao
OBJECTIVE: This study was designed to investigate the clinical effects of adopting perforator pedicled propeller flap in the proper digital artery for treatment and sensory reconstruction of finger pulp defects in children. PATIENTS AND METHODS: Perforator pedicled propeller flap of proper digital arteries in thirty-one fingers from twenty-three children patients were selected for repairing the pulp defects on the 2nd to the 5th fingers. All cases were treated from September 2012 to December 2013...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28923569/digestive-behavior-of-dendrobium-huoshanense-polysaccharides-in-the-gastrointestinal-tracts-of-mice
#5
Song-Zi Xie, Ji-Chun Ge, Fan Li, Jun Yang, Li-Hua Pan, Xue-Qiang Zha, Qiang-Ming Li, Jun Duan, Jian-Ping Luo
With fluorescent end-labeling method, a homogenous Dendrobium huoshanense polysaccharide (GXG) that was orally administrated to mice was found to be degraded into a stable fragment (dGXG) in the stomach, where dGXG was propelled into the small intestine and absorbed into the systemic circulation. The residual GXG in the stomach could pass through the gastrointestinal tract and was excreted into faeces with a very slow fermentation in the large intestine. The simulated digestion of GXG indicated that the acidic pH condition in the gastric fluid was responsible for GXG degradation, which was supported by the oral digestion of dGXG...
September 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28923127/thin-blue-lines-product-placement-and-the-drama-of-pregnancy-testing-in-british-cinema-and-television
#6
Jesse Olszynko-Gryn
This article uses the case of pregnancy testing in Britain to investigate the process whereby new and often controversial reproductive technologies are made visible and normalized in mainstream entertainment media. It shows how in the 1980s and 1990s the then nascent product placement industry was instrumental in embedding pregnancy testing in British cinema and television's dramatic productions. In this period, the pregnancy-test close-up became a conventional trope and the thin blue lines associated with Unilever's Clearblue rose to prominence in mainstream consumer culture...
September 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28922023/fatty-acid-synthase-fasn-as-a-therapeutic-target-in-breast-cancer
#7
Javier A Menendez, Ruth Lupu
Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a model to explain how FASN is intertwined with various signaling networks to cell-autonomously regulate breast cancer initiation and progression, FASN has received considerable attention as a therapeutic target. However, despite the ever-growing evidence demonstrating the involvement of FASN as part of the cancer-associated metabolic reprogramming, translation of the basic science-discovery aspects of FASN blockade to the clinical arena remains a challenge...
September 18, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28920714/expansible-thermal-gelling-foam-aerosol-for-vaginal-drug-delivery
#8
Liling Mei, Jintian Chen, Siqin Yu, Ying Huang, Yecheng Xie, Hui Wang, Xin Pan, Chuanbin Wu
Vaginal delivery of antimicrobial drugs is the most effective method for the local treatment of the vaginal infections. However, current vaginal drug delivery systems (VDDS), including gel, lotion, aerosol and cream, are suffering from low penetration in the deep vaginal rugae and easy elimination by self-cleaning of vaginal canal. To address these issues, a foam aerosol based on the thermal transformation was designed to improve penetration efficiency and achieve the extended retention. The expansible thermal gelling foam aerosol (ETGFA) consisting of thermal sensitive matrix, silver nanoparticle, adhesive agent and propellant, was optimized by evaluations of precursor viscosity, foam expansion, thermal gelation, gel adhesiveness, antimicrobial effects and tissue irritation...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28920114/nano-and-micromotors-for-cleaning-polluted-waters-focused-review-on-pollutant-removal-mechanisms
#9
REVIEW
Hamed Eskandarloo, Arkaye Kierulf, Alireza Abbaspourrad
Nano- and micromotors are machines designed to self-propel and-in the process of propelling themselves-perform specialized tasks like cleaning polluted waters. These motors offer distinct advantages over conventionally static decontamination methods, owing to their ability to move around and self-mix-which heightens the interaction between their active sites and target pollutants-thus improving their speed and efficiency, which could potentially decrease treatment times and costs. In the last decade, considerable research efforts have been expended on exploring various mechanisms by which these motors can self-propel and remove pollutants, proving that the removal of oil droplets, heavy metals, and organic compounds using these synthetic motors is possible...
September 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28916495/enzymes-as-key-features-in-therapeutic-cell-mimicry
#10
Fabian Itel, Philipp S Schattling, Yan Zhang, Brigitte Städler
Cell mimicry is a nature inspired concept that aims to substitute for missing or lost (sub)cellular function. This review focuses on the latest advancements in the use of enzymes in cell mimicry for encapsulated catalysis and artificial motility in synthetic bottom-up assemblies with emphasis on the biological response in cell culture or more rarely in animal models. Entities across the length scale from nano-sized enzyme mimics, sub-micron sized artificial organelles and self-propelled particles (swimmers) to micron-sized artificial cells are discussed...
September 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28915264/inhibition-of-infection-spread-by-co-transmitted-defective-interfering-particles
#11
Ashley Baltes, Fulya Akpinar, Bahar Inankur, John Yin
Although virus release from host cells and tissues propels the spread of many infectious diseases, most virus particles are not infectious; many are defective, lacking essential genetic information needed for replication. When defective and viable particles enter the same cell, the defective particles can multiply while interfering with viable particle production. Defective interfering particles (DIPs) occur in nature, but their role in disease pathogenesis and spread is not known. Here, we engineered an RNA virus and its DIPs to express different fluorescent reporters, and we observed how DIPs impact viral gene expression and infection spread...
2017: PloS One
https://www.readbyqxmd.com/read/28912602/kinetic-adaptation-of-human-myo19-for-active-mitochondrial-transport-to-growing-filopodia-tips
#12
Marko Ušaj, Arnon Henn
Myosins are actin-based molecular motors which are enzymatically adapted for their cellular functions such as transportation and membrane tethering. Human Myo19 affects mitochondrial motility, and promotes their localization to stress-induced filopodia. Therefore, studying Myo19 enzymology is essential to understand how this motor may facilitate mitochondrial motility. Towards this goal, we have purified Myo19 motor domain (Myo19-3IQ) from a human-cell expression system and utilized transient kinetics to study the Myo19-3IQ ATPase cycle...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912530/ros-induced-distribution-of-mitochondria-to-filopodia-by-myo19-depends-on-a-class-specific-tryptophan-in-the-motor-domain
#13
Boris I Shneyer, Marko Ušaj, Naama Wiesel-Motiuk, Ronit Regev, Arnon Henn
The role of the actin cytoskeleton in relation to mitochondria function and dynamics is only recently beginning to be recognized. Myo19 is an actin-based motor that is bound to the outer mitochondrial membrane and promotes the localization of mitochondria to filopodia in response to glucose starvation. However, how glucose starvation induces mitochondria localization to filopodia, what are the dynamics of this process and which enzymatic adaptation allows the translocation of mitochondria to filopodia are not known...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912390/-osteoporosis-liaison-service-and-multi-medical-staff-cooperation
#14
Satoshi Ikeda
A place of the activity of Osteoporosis Liaison Service (OLS) is classified into the in-hospital and the out-hospital. "Kotsu-Kotsu approach" is performed in our hospital for fracture inpatients as OLS. "Kotsu-Kotsu approach" can be able to performed the various and comprehensive assessment for the patients by multi medical staff, especially Osteoporosis managers. The construction of the cooperation with other facilities is propelled for activity of out-hospital. Ministry of Health, Labour and Welfare impel to establish community-based integrated care systems...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28912156/neutrophils-are-critical-for-myelin-removal-in-a-peripheral-nerve-injury-model-of-wallerian-degeneration
#15
Jane A Lindborg, Matthias Mack, Richard E Zigmond
Wallerian degeneration (WD) is considered an essential preparatory stage to the process of axonal regeneration. In the peripheral nervous system, infiltrating monocyte-derived macrophages that utilize the chemokine receptor CCR2 to gain entry to injured tissues from the bloodstream, are purportedly necessary for efficient WD. However, our lab has previously reported that myelin clearance in the injured sciatic nerve proceeds unhindered in the Ccr2(-/-) mouse model. Here, we extensively characterize WD in male Ccr2(-/-) mice and identify a compensatory mechanism of WD that is facilitated primarily by neutrophils...
September 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28905474/steer-prop-a-grase-propeller-sequence-with-interecho-steering-gradient-pulses
#16
Girish Srinivasan, Novena Rangwala, Xiaohong Joe Zhou
PURPOSE: This study demonstrates a novel PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction) pulse sequence, termed Steer-PROP, based on gradient and spin echo (GRASE), to reduce the imaging times and address phase errors inherent to GRASE. The study also illustrates the feasibility of using Steer-PROP as an alternative to single-shot echo planar imaging (SS-EPI) to produce distortion-free diffusion images in all imaging planes. METHODS: Steer-PROP uses a series of blip gradient pulses to produce N (N = 3-5) adjacent k-space blades in each repetition time, where N is the number of gradient echoes in a GRASE sequence...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28903755/prevalence-of-k13-mutation-and-day-3-positive-parasitaemia-in-artemisinin-resistant-malaria-endemic-area-of-cambodia-a-cross-sectional-study
#17
Soy Ty Kheang, Siv Sovannaroth, Sovann Ek, Say Chy, Phally Chhun, Sokkieng Mao, Sokomar Nguon, Dy Soley Lek, Didier Menard, Neeraj Kak
BACKGROUND: The presence of artemisinin-resistant malaria parasites was confirmed in western Cambodia in 2009. In 2013, mutations in the propeller domain of the kelch protein K13 was found to be associated with artemisinin resistance. A cross-sectional study was conducted to determine the prevalence of Day-3 parasitaemia, estimate the frequency of k13 molecular marker and assess their relationship in the context of operational research. METHODS: Blood smears and filter paper blood spots were collected from febrile patients in Kravanh District, Pursat Province...
September 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28903627/reliability-and-minimal-detectable-change-of-a-new-treadmill-based-progressive-workload-incremental-test-to-measure-cardiorespiratory-fitness-in-manual-wheelchair-users
#18
Cindy Gauthier, Jasmine Arel, Rachel Brosseau, Audrey L Hicks, Dany H Gagnon
Background Cardiorespiratory fitness training is commonly provided to manual wheelchair users (MWUs) in rehabilitation and physical activity programs, emphasizing the need for a reliable task-specific incremental wheelchair propulsion test. Objective Quantifying test-retest reliability and minimal detectable change (MDC) of key cardiorespiratory fitness measures following performance of a newly developed continuous treadmill-based wheelchair propulsion test (WPTTreadmill). Methods Twenty-five MWUs completed the WPTTreadmill on two separate occasions within one week...
September 13, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28902492/rheotaxis-of-bimetallic-micromotors-driven-by-chemical-acoustic-hybrid-power
#19
Liqiang Ren, Dekai Zhou, Zhangming Mao, Pengtao Xu, Tony Jun Huang, Thomas E Mallouk
Rheotaxis is a common phenomenon in nature that refers to the directed movement of micro-organisms as a result of shear flow. The ability to mimic natural rheotaxis using synthetic micro/nanomotors adds functionality to enable their applications in biomedicine and chemistry. Here, we present a hybrid strategy that can achieve both positive and negative rheotaxis of synthetic bimetallic micromotors by employing a combination of chemical fuel and acoustic force. An acoustofluidic device is developed for the integration of the two propulsion mechanisms...
September 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28901732/black-silicon-elastomer-composite-surface-with-switchable-wettability-and-adhesion-between-lotus-and-rose-petal-effects-by-mechanical-strain
#20
Jun Kyu Park, Zining Yang, Seok Kim
Although many recent studies demonstrate surfaces with switchable wettability under various external stimuli, a deliberate effort to self-propel liquid droplets utilizing a surface wetting mode switch between slippery lotus and adhesive rose petal states via a mechanical strain has not been made yet, which would otherwise further benefit microfluidic applications. In this work, we present a black silicon/elastomer (bSi/elastomer) composite surface which shows switchable wettability and adhesion across the two wetting modes by mechanical stretching...
September 13, 2017: ACS Applied Materials & Interfaces
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