keyword
MENU ▼
Read by QxMD icon Read
search

Propel

keyword
https://www.readbyqxmd.com/read/28315142/rotational-motion-of-dimers-of-janus-particles
#1
Arghya Majee
We theoretically study the motion of a rigid dimer of self-propelling Janus particles. In a simple kinetic approach without hydrodynamic interactions, the dimer moves on a helical trajectory and, at the same time, it rotates about its center of mass. Inclusion of the effects of mutual advection using superposition approximation does not alter the qualitative features of the motion but merely changes the parameters of the trajectory and the angular velocity.
March 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28314283/stable-shrna-silencing-of-lactate-dehydrogenase-a-ldha-in-human-mda-mb-231-breast-cancer-cells-fails-to-alter-lactic-acid-production-glycolytic-activity-atp-or-survival
#2
Nzinga Mack, Elizabeth A Mazzio, David Bauer, Hernan Flores-Rozas, Karam F A Soliman
BACKGROUND: In the US, African Americans have a high death rate from triple-negative breast cancer (TNBC), characterized by lack of hormone receptors (ER, PR, HER2/ERRB2) which are otherwise valuable targets of chemotherapy. There is a need to identify novel targets that negatively impact TNBC tumorigenesis. TNBCs release an abundance of lactic acid, under normoxic, hypoxic and hyperoxic conditions; this referred to as the Warburg effect. Accumulated lactic acid sustains peri-cellular acidity which propels metastatic invasion and malignant aggressive transformation...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28314066/comparison-of-propeller-perforator-flap-and-venous-supercharged-propeller-perforator-flap-in-reconstruction-of-lower-limb-soft-tissue-defect-a-prospective-study
#3
Benoit Chaput, Nicolas Bertheuil, Jean-Louis Grolleau, Farid Bekara, Raphael Carloni, Jerome Laloze, Christian Herlin
INTRODUCTION: In lower limbs, reliability of propeller perforator flaps (PPF) remains uncertain. The main complication is venous congestion, which can lead to distal necrosis. We aim to highlight if venous supercharging of PPF could substantially limit complications in lower limb coverage. METHODS: Between 2011 and 2016, we developed a standardized procedure of venous supercharging in the lower limb reconstruction with PPF using saphenous veins anastomosis. Then, we prospectively compared a consecutive series of 30 PPF to cover lower limbs defect, with a consecutive series of 30 venous-supercharged PPF (vsPPF)...
March 17, 2017: Microsurgery
https://www.readbyqxmd.com/read/28298440/structural-basis-of-outer-dynein-arm-intraflagellar-transport-by-the-transport-adaptor-protein-oda16-and-the-intraflagellar-transport-protein-ift46
#4
Michael Taschner, André Mourão, Mayanka Awasthi, Jerome Basquin, Esben Lorentzen
Motile cilia are found on unicellular organisms such as the green alga Chlamydomonas reinhardtii, on sperm cells, and on cells that line the trachea and fallopian tubes in mammals. The motility of cilia relies on a number of large protein complexes including the force-generating outer dynein arms (ODAs). The transport of ODAs into cilia has been previously shown to require the transport adaptor ODA16 as well as the intraflagellar transport (IFT) protein IFT46, but the molecular mechanism by which ODAs are recognized and transported into motile cilia is still unclear...
March 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28297968/lattice-boltzmann-simulations-of-microswimmer-tracer-interactions
#5
Joost de Graaf, Joakim Stenhammar
Hydrodynamic interactions in systems composed of self-propelled particles, such as swimming microorganisms and passive tracers, have a significant impact on the tracer dynamics compared to the equivalent "dry" sample. However, such interactions are often difficult to take into account in simulations due to their computational cost. Here, we perform a systematic investigation of swimmer-tracer interaction using an efficient force-counterforce-based lattice-Boltzmann (LB) algorithm [De Graaf et al., J. Chem...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297865/numerical-study-of-nonequilibrium-gas-flow-in-a-microchannel-with-a-ratchet-surface
#6
Lianhua Zhu, Zhaoli Guo
The nonequilibrium gas flow in a two-dimensional microchannel with a ratchet surface and a moving wall is investigated numerically with a kinetic method [Guo et al., Phys. Rev. E 91, 033313 (2015)]PLEEE81539-375510.1103/PhysRevE.91.033313. The presence of periodic asymmetrical ratchet structures on the bottom wall of the channel and the temperature difference between the walls of the channel result in a thermally induced flow, and hence a tangential propelling force on the wall. Such thermally induced propelling mechanism can be utilized as a model heat engine...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28296018/assembly-and-transport-of-microscopic-cargos-via-reconfigurable-photoactivated-magnetic-microdockers
#7
Fernando Martinez-Pedrero, Helena Massana-Cid, Pietro Tierno
The realization of micromotors able to dock and transport microscopic objects in a fluid medium has direct applications toward the delivery of drugs and chemicals in small channels and pores, and the realization of functional wireless microrobots in lab-on-a-chip technology. A simple and general method to tow microscopic particles in water by using remotely controllable light-activated hematite microdockers is demonstrated. These anisotropic ferromagnetic particles can be synthesized in bulk and present the remarkable ability to be activated by light while independently manipulated via external fields...
March 15, 2017: Small
https://www.readbyqxmd.com/read/28292904/optimal-run-and-tumble-based-transportation-of-a-janus-particle-with-active-steering
#8
Tomoyuki Mano, Jean-Baptiste Delfau, Junichiro Iwasawa, Masaki Sano
Although making artificial micrometric swimmers has been made possible by using various propulsion mechanisms, guiding their motion in the presence of thermal fluctuations still remains a great challenge. Such a task is essential in biological systems, which present a number of intriguing solutions that are robust against noisy environmental conditions as well as variability in individual genetic makeup. Using synthetic Janus particles driven by an electric field, we present a feedback-based particle-guiding method quite analogous to the "run-and-tumbling" behavior of Escherichia coli but with a deterministic steering in the tumbling phase: the particle is set to the run state when its orientation vector aligns with the target, whereas the transition to the "steering" state is triggered when it exceeds a tolerance angle [Formula: see text] The active and deterministic reorientation of the particle is achieved by a characteristic rotational motion that can be switched on and off by modulating the ac frequency of the electric field, which is reported in this work...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28292891/distinct-recognition-of-complement-ic3b-by-integrins-%C3%AE-x%C3%AE-2-and-%C3%AE-m%C3%AE-2
#9
Shutong Xu, Jianchuan Wang, Jia-Huai Wang, Timothy A Springer
Recognition by the leukocyte integrins αXβ2 and αMβ2 of complement iC3b-opsonized targets is essential for effector functions including phagocytosis. The integrin-binding sites on iC3b remain incompletely characterized. Here, we describe negative-stain electron microscopy and biochemical studies of αXβ2 and αMβ2 in complex with iC3b. Despite high homology, the two integrins bind iC3b at multiple distinct sites. αXβ2 uses the αX αI domain to bind iC3b on its C3c moiety at one of two sites: a major site at the interface between macroglobulin (MG) 3 and MG4 domains, and a less frequently used site near the C345C domain...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28290784/-the-familial-hypercholesterolemia-caused-by-a-novel-human-low-density-lipoprotein-receptor-gene-mutation-c-1327-t-c-p-w433r
#10
V A Korneva, T Yu Kuznetsova, R Z Murtazina, A V Didio, T Yu Bogoslovskaya, M Yu Mandelshtam, V B Vasilyev
During investigation of molecular nature of familial hypercholesterolemia (FH) in Petrozavodsk (Russia) cohort of patients a novel low density lipoprotein (LDL) receptor gene mutation was found. This mutation designated c.1327 T>C (W443R [W422R]) was predicted to cause substitution of arginine for tryptophan residue in the very conservative -propeller domain of the LDL receptor. Inheritance of the new mutation was traced in four generations and its cosegregation with hypercholesterolemia phenotype was observed...
February 2017: Kardiologiia
https://www.readbyqxmd.com/read/28290654/new-ulvan-degrading-polysaccharide-lyase-family-structure-and-catalytic-mechanism-suggests-convergent-evolution-of-active-site-architecture
#11
ThirumalaiSelvi Ulaganathan, Michal T Boniecki, Elizabeth Foran, Vitaliy Buravenkov, Naama Mizrachi, Ehud Banin, William Helbert, Miroslaw Cygler
Ulvan is a complex sulfated polysaccharide biosynthesized by green seaweed and contains predominantly rhamnose, xylose and uronic acids sugars. Ulvan-degrading enzymes have only recently been identified added to the CAZy (www.cazy.org) database, but neither their structure nor catalytic mechanism(s) are yet known. One of the new ulvan lyases was discovered in Pseudoalteromonas sp. strain PLSV and is encoded by the gene PLSV_3936. This enzyme cleaves the glycosidic bond between 3-sulfated rhamnose (R3S) and glucuronic acid (GluA) or iduronic acid (IdoA) via a -elimination mechanism...
March 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28290242/variation-in-impact-of-use-of-different-propellants-and-excipients-in-pharmaceutical-topical-aerosol-then-and-now
#12
Maunab Patra, Meenakshi Patnaik
Skin is the most suitable and recommendable organ of the human body for topical administration of drugs. Drug delivery system is the methodology used to ensure that the drugs entering in to the body through any route into the body, reach its target for pharmacological action. Patients tend to prefer the painless route of drug administration. So, pharmaceutical aerosols were invented meet patient compliance. Many variations in excipients with respect to compatibility to drugs, stability and economy have been used since start to improve the aerosol system of drug delivery...
March 8, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28289248/antimalarial-drug-resistance-a-threat-to-malaria-elimination
#13
Didier Menard, Arjen Dondorp
Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins has emerged in the Greater Mekong Subregion. Concomitant emergence of partner drug resistance is now causing high ACT treatment failure rates in several areas. Genetic markers for artemisinin resistance and several of the partner drugs have been established, greatly facilitating surveillance...
March 13, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28283966/data-standardization-and-quality-management
#14
Paul A Lapchak, John H Zhang
Important questions regarding the conduct of scientific research and data transparency have been raised in various scientific forums over the last 10 years. It is becoming clear, that in spite of published RIGOR guidelines, that improvement in the transparency of scientific research is required to focus on the discovery and drug development process so that a treatment can be provided to stroke patients. We have the unique privilege of conducting research using animal models of a disease so that we can address the development of a new therapy, and we should do this with great care and vigilance...
March 10, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28278008/the-influence-of-axle-position-and-the-use-of-accessories-on-the-activity-of-upper-limbs-muscles-during-manual-wheelchair-propulsion
#15
Guilherme da Silva Bertolaccini, Idinei Francisco Pires de Carvalho Filho, Gustavo Christofoletti, Luis Carlos Paschoarelli, Fausto Orsi Medola
INTRODUCTION: Wheelchair configuration is an important factor influencing the ergonomics of user-device interface and, from a biomechanical point of view, small changes in the chair setup may have a positive influence on the demand on the upper limbs during manual propulsion. This study aimed to investigate the influence of the position of the rear wheels' axle and the use of accessories on the activity of upper limb muscles during manual wheelchair propulsion. METHODS: Electromyography signal of the biceps, triceps, anterior deltoids and pectoralis major were collected with eleven able-bodied subjects in a wheelchair propulsion protocol with four different wheelchair configurations (differing in axle position and the use of accessories) in straightforward sprint and slalom course...
February 17, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28277904/genome-wide-functional-analysis-in-candida-albicans
#16
Thabiso E Motaung, Ruan Ells, Carolina H Pohl, Jacobus Albertyn, Toi J Tsilo
Candida albicans is an important etiological agent of superficial and life-threatening infections in individuals with compromised immune systems. To date, we know of several overlapping genetic networks that govern virulence attributes in this fungal pathogen. Classical use of deletion mutants has led to the discovery of numerous virulence factors over the years, and genome-wide functional analysis has propelled gene discovery at an even faster pace. Indeed, a number of recent studies using large-scale genetic screens followed by genome-wide functional analysis has allowed for the unbiased discovery of many new genes involved in C...
February 8, 2017: Virulence
https://www.readbyqxmd.com/read/28277838/using-natural-products-for-drug-discovery-the-impact-of-the-genomics-era
#17
Mingzi M Zhang, Qiao Yuan, Ee Lui Ang, Huimin Zhao
Evolutionarily selected over billions of years for their interactions with biomolecules, natural products have been and continue to be a major source of pharmaceuticals. In the 1990s, pharmaceutical companies scaled down their natural product discovery programs in favor of synthetic chemical libraries due to major challenges such as high rediscovery rates, challenging isolation, and low production titers. Propelled by advances in DNA sequencing and synthetic biology technologies, insights into microbial secondary metabolism provided have inspired a number of strategies to address these challenges...
March 4, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28277676/mechanistic-basis-for-the-binding-of-rgd-and-agdv-peptides-to-the-platelet-integrin-%C3%AE-iib%C3%AE-3
#18
Olga Kononova, Rustem I Litvinov, Dmitry S Blokhin, Vladimir V Klochkov, John W Weisel, Joel S Bennett, Valeri Barsegov
Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the C-terminal AGDV-containing dodecapeptide (γC-12) sequence of the fibrinogen γ chain. However, peptides containing the Arg-Gly-Asp (RGD) sequences located in two places in the fibrinogen Aα chain inhibit soluble fibrinogen binding to αIIbβ3 and make substantial contributions to αIIbβ3 binding when fibrinogen is immobilized and when it is converted to fibrin...
March 9, 2017: Biochemistry
https://www.readbyqxmd.com/read/28273103/functional-metagenomics-reveals-novel-%C3%AE-galactosidases-not-predictable-from-gene-sequences
#19
Jiujun Cheng, Tatyana Romantsov, Katja Engel, Andrew C Doxey, David R Rose, Josh D Neufeld, Trevor C Charles
The techniques of metagenomics have allowed researchers to access the genomic potential of uncultivated microbes, but there remain significant barriers to determination of gene function based on DNA sequence alone. Functional metagenomics, in which DNA is cloned and expressed in surrogate hosts, can overcome these barriers, and make important contributions to the discovery of novel enzymes. In this study, a soil metagenomic library carried in an IncP cosmid was used for functional complementation for β-galactosidase activity in both Sinorhizobium meliloti (α-Proteobacteria) and Escherichia coli (γ-Proteobacteria) backgrounds...
2017: PloS One
https://www.readbyqxmd.com/read/28272870/enhanced-thermal-decomposition-properties-of-cl-20-through-space-confining-in-three-dimensional-hierarchically-ordered-porous-carbon
#20
Jin Chen, Simin He, Bing Huang, Peng Wu, Zhiqiang Qiao, Jun Wang, Liyuan Zhang, Guangcheng Yang, Hui Huang
High energy and low signature properties are the future trend of solid propellant development. As a new and promising oxidizer, hexanitrohexaazaisowurtzitane (CL-20) is expected to replace the conventional oxidizer ammonium perchlorate to reach above goals. However, the high pressure exponent of CL-20 hinders its application in solid propellants so that the development of effective catalysts to improve the thermal decomposition properties of CL-20 still remains challenging. Here, 3D hierarchically ordered porous carbon (3D HOPC) is presented as a catalyst for the thermal decomposition of CL-20 via synthesizing a series of nanostructured CL-20/HOPC composites...
March 17, 2017: ACS Applied Materials & Interfaces
keyword
keyword
114780
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"