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Julie Besnardiere, Xavier Petrissans, François Ribot, Valérie Briois, Christine Surcin, Mathieu Morcrette, Valérie Buissette, Thierry Le Mercier, Sophie Cassaignon, David Portehault
An aqueous synthetic route at 95 °C is developed to reach selectively three scarcely reported vanadium oxyhydroxides. Häggite V2O3(OH)2, Duttonite VO(OH)2, and Gain's hydrate V2O4(H2O)2 are obtained as nanowires, nanorods, and nanoribbons, with sizes 1 order of magnitude smaller than previously reported. X-ray absorption spectroscopy provides evidence that vanadium in these phases is V(+IV). Combined with FTIR, XRD, and electron microscopy, it yields the first insights into formation mechanisms, especially for Häggite and Gain's hydrate...
October 12, 2016: Inorganic Chemistry
Tzipora C Falik Zaccai, Limor Kalfon, Aharon Klar, Mordechai Ben Elisha, Haggit Hurvitz, Galina Weingarten, Emelia Chechik, Vered Fleisher Sheffer, Raid Haj Yahya, Gal Meidan, Eva Gross-Kieselstein, Dvora Bauman, Sylvia Hershkovitz, Yuval Yaron, Avi Orr-Urtreger, Efrat Wertheimer
Donohue syndrome (DS) is a rare and lethal autosomal recessive disease caused by mutations in the insulin receptor (INSR) gene, manifesting marked insulin resistance, severe growth retardation, hypertrichosis, and characteristic dysmorphic features. We report the clinical, molecular, and biochemical characterization of three new patients with DS, and address genotype-phenotype issues playing a role in the pathophysiology of DS. A female infant born to first-degree cousins Muslim Arab parents and two brothers born to first-degree cousins Druze parents presented classical features of DS with hypertrophic cardiomyopathy and died in infancy...
January 2014: Molecular Genetics & Genomic Medicine
Elisabeth C McLemore, Alisa Coker, Garth Jacobsen, Mark A Talamini, Santiago Horgan
BACKGROUND: Transanal endoscopic microsurgical (TEM) resection is associated with improved outcomes compared to transanal excision of rectal lesions. However, TEM equipment requires additional operative setup time, and tumor location dictates patient positioning. In 2010, Drs. Attallah, Albert, and Larach developed an alternative technique, transanal minimally invasive surgery (TAMIS). Herein, we describe our novel experience using endoscopic visualization to perform TAMIS (eTAMIS) to remove a large rectal polyp...
May 2013: Surgical Endoscopy
Wendy Westbroek, Aharon Klar, Andrew R Cullinane, Shira G Ziegler, Haggit Hurvitz, Ashraf Ganem, Kirkland Wilson, Heidi Dorward, Marjan Huizing, Haled Tamimi, Igor Vainshtein, Yackov Berkun, Moran Lavie, William A Gahl, Yair Anikster
The RAB27A/Melanophilin/Myosin-5a tripartite protein complex is required for capturing mature melanosomes in the peripheral actin network of melanocytes for subsequent transfer to keratinocytes. Mutations in any one member of this tripartite complex cause three forms of Griscelli syndrome (GS), each with distinct clinical features but with a similar cellular phenotype. To date, only one case of GS type III (GSIII), caused by mutations in the Melanophilin (MLPH) gene, has been reported. Here, we report seven new cases of GSIII in three distinct Arab pedigrees...
January 2012: Pigment Cell & Melanoma Research
Aharon Klar, Paulina Navon-Elkan, Alan Rubinow, David Branski, Haggit Hurvitz, Ernst Christensen, Morad Khayat, Tzipora C Falik-Zaccai
Three siblings with recalcitrant leg ulceration, splenomegaly, photosensitive rash, and autoantibodies were suspected of having prolidase deficiency. Urine was checked for iminodipeptiduria, fibroblasts were cultured and analyzed for prolidase activity, and DNA was extracted for identifying the causative mutation. Glycyl proline was found as the dominant dipeptide in the urine. The activity of proline dipeptidase in fibroblasts was 2.5% of control fibroblasts. Sequence analysis of the PEPD gene revealed a homozygous nonsense C-->G transition at nucleotide 768...
June 2010: European Journal of Pediatrics
Changzheng Wu, Jun Dai, Xiaodong Zhang, Jinlong Yang, Yi Xie
Synthetic haggite V(4)O(6)(OH)(4) has been successfully obtained for the first time after a delay of more than 50 years. Our careful analysis clarifies the formula of haggite as V(4)O(6)(OH)(4), rather than the long-standing known V(4)O(4)(OH)(6). The semiconductor of haggite shows a rapid increase of resistance by >10(4) orders of magnitude down to low temperatures, giving the first case of the oxyhydroxide compound showing semiconductor-insulator transitions. More intriguingly, the haggite product's nanobelt that can act as connecting units have potential in the construction of intelligent switching devices in future investigations...
June 3, 2009: Journal of the American Chemical Society
Haggit Ben-Israel, Rakefet Sharf, Gideon Rechavi, Tamar Kleinberger
The adenovirus E4 open reading frame 4 (E4orf4) protein is a multifunctional viral regulator that is involved in the temporal regulation of viral gene expression by modulating cellular and viral genes at the transcription and translation levels and by controlling alternative splicing of adenoviral late mRNAs. When expressed individually, E4orf4 induces apoptosis in transformed cells. Using oligonucleotide microarray analysis, validated by quantitative real time PCR, we found that MYC (also known as c-Myc) is downregulated early after the induction of E4orf4 expression...
October 2008: Journal of Virology
Michal Haviv, Eitan Haver, David Lichtstein, Haggit Hurvitz, Aharon Klar
Atrial natriuretic peptide (ANP) has known natriuretic, diuretic, and vasodilatatory effects. It is synthesized and stored in the atrial cells. Stretching of the atrial muscle fibers during an increase in venous return sets a response of ANP release into the blood stream. High levels of ANP were measured in a number of lung diseases. Pneumonia in children is frequently accompanied by the hyponatremia of the syndrome of inappropriate antidiuretic hormone (ADH) secretion (SIADH). High levels of ANP were found among patients with SIADH...
October 2005: Pediatric Pulmonology
Aharon Klar, David Branski, Yaacov Akerman, Michael Nadjari, Yaacov Berkun, Jonathan Moise, Gila Shazberg, Shoshana Revel-Vilk, Talia Israeli, Gabriel Katz, Arie Levy, Anat Ben Ami, Haggit Hurvitz
OBJECTIVE: Evaluation and follow-up of infants with cholelithiasis and pseudolithiasis in a pediatric ward. PATIENTS & METHODS: Prospective study from April 1990 to October 2003 identified hospitalized infants younger than 2 years with ultrasonographic findings of cholelithiasis, choledocholithiasis or pseudolithiasis. Associated abnormalities or contributory factors were recorded and patients were followed for from 6 months to 13 years (mean, 4 years). RESULTS: Thirty-four patients were diagnosed between the age of 3 weeks and 24 months...
April 2005: Journal of Pediatric Gastroenterology and Nutrition
Yackov Berkun, Abraham Brand, Aharon Klar, Efraim Halperin, Haggit Hurvitz
No abstract text is available yet for this article.
November 2004: European Journal of Pediatrics
Aharon Klar, David Shoseyov, Yaakov Berkun, Abraham Brand, Jacques Braun, Gila Shazberg, Moise Jonathan, Eva Gross-Kieselstein, Shoshana Revel-Vilk, Haggit Hurvitz
BACKGROUND: Intestinal protein loss has been reported mainly in diseases affecting the gastrointestinal tract. Intestinal protein loss during pneumonia with effusion has not been reported to date. The authors attempted to assess the associations between pneumonia with effusion and intestinal protein loss and hypoalbuminemia in children. METHODS: This was a prospective consecutive case series study of in children hospitalized with pneumonia and effusion during a period of 4(1/2) years...
August 2003: Journal of Pediatric Gastroenterology and Nutrition
Isabelle Korn-Lubetzki, Talia Dor-Wollman, Dov Soffer, Annick Raas-Rothschild, Haggit Hurvitz, Yoram Nevo
Early infantile Krabbe disease is relatively frequent in the Muslim-Arab population in Israel. It can be easily diagnosed when it presents with the classic clinical picture characterized by central nervous system manifestations of spasticity, irritability, motor regression and seizures associated with a positive family history. We studied eight children diagnosed with Krabbe disease. In two of these children (25%), peripheral neuropathy was the single initial symptom and the only neurologic finding noted for a period of months...
February 2003: Pediatric Neurology
Aharon Klar, Ariel Halamish, David Shoseyov, Pascal Cassinotti, Gunter Siegl, Chaim Springer, Gila Shazberg, Haggit Hurvitz
No abstract text is available yet for this article.
October 2002: Israel Medical Association Journal: IMAJ
Yair Anikster, Marjan Huizing, Paul D Anderson, Diana L Fitzpatrick, Aharon Klar, Eva Gross-Kieselstein, Yackov Berkun, Gila Shazberg, William A Gahl, Haggit Hurvitz
Griscelli syndrome (GS), a rare autosomal recessive disorder, is characterized by partial albinism, along with immunologic abnormalities or severe neurological impairment or both. Mutations in one of two different genes on chromosome 15q can cause the different subtypes of GS. Most patients with GS display the hemophagocytic syndrome and have mutations in RAB27A, which codes for a small GTPase. Two patients with neurological involvement have mutations in MYO5A, which codes for an actin-based molecular motor...
August 2002: American Journal of Human Genetics
Haggit Ben-Israel, Tamar Kleinberger
Adenovirus infection of quiescent cells induces transition from G0 or G1 into the S phase of the cell cycle and allows cellular proliferation. This is beneficial for the virus since cells in S phase provide optimal conditions for viral replication. Adenovirus E1A, E1B and E4 gene products contribute to cell cycle deregulation. E1A proteins inactivate the pRb checkpoint, allowing the E2F transcription factor to activate genes involved in nucleotide metabolism and DNA replication, which are required in S phase...
May 1, 2002: Frontiers in Bioscience: a Journal and Virtual Library
Orly N Elpeleg, Avraham Shaag, Elizabeth Holme, Ghaleb Zughayar, Suzi Ronen, Drora Fisher, Haggit Hurvitz
Thirteen Israeli patients with type I tyrosinemia were studied. To the best of our knowledge, this group represents all of the patients that were diagnosed in Israel during the years 1987-1997. Their age of onset was variable but all the patients suffered from liver disease at presentation. Six died at 3 to 36 months of age, whereas the remaining 7, in whom NTBC was started at 5 to 30 months, are alive and well at 4 to 11 years. Three mutations were identified: a mis-splicing IVS8-1G>C mutation in a large Moslem kindred, Pro261Leu mutation in all Jewish patients, and the IVS12+5G>A mutation, commonly found in French Canadian patients...
January 2002: Human Mutation
F W Nugent, R C Haggit, H Colcher, G C Kutteruf
Prior studies confirm the increased incidence of carcinoma of the colon in chronic ulcerative colitis. The authors reviewed clinical and histologic data retrospectively in 23 patients with colon carcinoma and chronic ulcerative colitis. Twenty-two of these patients had dysplasia of colonic epithelium remote from the cancer. The authors prospectively reviewed clinical data and rectal and colonoscopic biopsy specimens on 36 patients with chronic ulcerative colitis, 12 with Crohn's colitis, and 12 with miscellaneous disorders...
January 1979: Gastroenterology
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