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diagnostic cytopathology

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https://www.readbyqxmd.com/read/28818609/multicenter-comparison-of-22c3-pharmdx-agilent-and-sp263-ventana-assays-to-test-pd-l1-expression-for-nsclc-patients-to-be-treated-with-immune-checkpoint-inhibitors
#1
Antonio Marchetti, Massimo Barberis, Renato Franco, Graziano De Luca, Maria Vittoria Pace, Stefania Staibano, Marco Volante, Fiamma Buttitta, Elena Guerini-Rocco, Luisella Righi, Tommaso D'antuono, Giorgio V Scagliotti, Carmine Pinto, Gaetano De Rosa, Mauro Papotti
INTRODUCTION: Among the several agents targeting the programmed cell death 1 (PD-1) pathway, pembrolizumab is currently the only one approved for the treatment of non-small cell lung cancer patients in association with a companion diagnostic assay, the anti-programmed cell death ligand 1 (PD-L1) immunohistochemical (IHC) 22C3 PharmDx (Agilent) using the Dako Autostainer. However, the Dako platform is not present in each pathology department and this technical limitation is a major problem for the diffusion of the PD-L1 IHC predictive test for pembrolizumab...
August 14, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28811803/a-study-of-galactin-3-on-fine-needle-aspiration-as-a-diagnostic-marker-differentiating-benign-from-malignant-thyroid-neoplasm
#2
Alliya Muzafar, Mulazim Hussain Bukhari, Ihtesham Uddin Qureshi
BACKGROUND & OBJECTIVE: Thyroid nodules are very common in our setup and their diagnosis on fine needle aspiration is not easy and is a taxing affair. It is a challenge to differentiate between follicular adenoma and follicular carcinoma without histology. Our objective was to investigate the role of Galectin-3 in fine needle aspirates of thyroid nodules as a prospective diagnostic marker and consequently its ability to differentiate benign from malignant neoplasms. METHODS: The research was conducted at the department of Pathology, King Edward Medical University, in association with other teaching institutions of Lahore from June 2012 to July 2014...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28791453/-the-paris-system-for-classification-of-urinary-cytology
#3
S Savic, T Vlajnic, L Bubendorf
A uniform classification system for reporting urinary cytology has not been available until recently, although urinary cytology represents an important volume of specimens in cytopathology laboratories and is well-established in the diagnosis and follow-up of patients with urothelial carcinoma. The Paris system is the first internationally accepted classification system, which allows uniform reporting of urinary cytology based on standardized morphological criteria. It emphasizes the detection of potentially life-threatening high-grade urothelial carcinomas and well-defined diagnostic categories have been developed...
August 8, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28772003/case-of-chondroid-syringoma-mimicking-as-nodular-hidradenoma-a-diagnostic-pitfall-on-cytopathology
#4
Bahadur Shalini, Katyal Akshi, Nargotra Namrata, Soni Shilpi, Nain Manupriya
Limited literature is available on the use of fine needle aspiration (FNA) for skin tumors. Awareness of cytological features of these lesions is important to prevent misdiagnosis. A 45-year-old male, presented with slowly growing swelling over the thigh since 4 years. FNA from multiple sites yielded highly cellular smears with a dual cell population consisting of cells with small round nucleus scanty cytoplasm and polygonal cells with moderate to abundant cytoplasm. Extracellular basement membrane like material was also noted...
August 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28759963/nondiagnostic-cytological-results-on-ultrasound-guided-fine-needle-aspiration-does-the-thyroid-nodule-depth-matter
#5
Jia-Jing Xia, Meng-Sen Li, Li Zhen, You-Zhen Shi
OBJECTIVE: To evaluate whether thyroid nodule depth and other ultrasound features can predict nondiagnostic cytological results on ultrasound-guided fine needle aspiration. MATERIAL AND METHODS: This retrospective study included 412 thyroid nodules that underwent ultrasound-guided fine needle aspiration from 2014 to 2015. The nodules were classified as nondiagnostic and diagnostic by the cytopathological results. Clinical information of the patients (ie., age, sex) and ultrasound features (ie...
July 25, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28741442/a-systematic-review-of-the-methods-of-diagnostic-accuracy-studies-of-the-afirma%C3%A2-gene-expression-classifier
#6
Quan-Yang Duh, Naifa Busaidy, Catherine Rahilly-Tierney, Hossein Gharib, Gregory W Randolph
BACKGROUND: The Afirma® Gene Expression Classifier (GEC) risk-stratifies Bethesda System for the Reporting of Thyroid Cytopathology class III/IV (indeterminate) thyroid nodules (ITNs) as Suspicious for malignancy or Benign. Several authors have published studies describing the diagnostic accuracy of the GEC. However, the quality of these methods has not been rigorously examined. SUMMARY: We searched Medline and EMBASE for studies published between January 1, 2010 and June 30, 2016 examining the sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of the GEC...
July 25, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28731534/internal-quality-control-in-an-academic-cytopathology-laboratory-for-the-introduction-of-a-new-reporting-system-for-endometrial-cytology
#7
Niki Margari, Abraham Pouliakis, Dionysios Aninos, Christos Meristoudis, Magdalini Stamataki, Ioannis Panayiotides, Petros Karakitsos
BACKGROUND: To evaluate reproducibility of a reporting system for endometrial cytology. METHODS: Cytologic slides from 49 patients, prepared via liquid based cytology, were blindly examined by five cytopathologists of various experience levels, applying a recently introduced reporting system as previously reported. The agreement among cytopathologists was evaluated via Kappa (κ) statistics and the Kendall's Coefficient of Variation (W); cytologic results were compared with the relevant histologic report...
July 21, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28718513/the-fine-needle-aspiration-of-translocation-sarcomas
#8
C J VandenBussche, C L Adams, O G McDonald, S A Whitworth, S Z Ali
INTRODUCTION: Soft tissue sarcomas comprise a heterogeneous group of clinically aggressive cancers that are often hard to classify on limited cytological samples. "Translocation sarcomas" (TS) are a diverse subset of such cancers, different from pleomorphic sarcomas, and characterised by unique single chromosomal translocations in each sarcoma subtype. Interestingly, despite their high-grade biological behaviour, TS have deceptively monotonous and bland cytomorphology, therefore creating diagnostic issues on limited samples...
July 17, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28708928/the-milan-system-for-reporting-salivary-gland-cytopathology-analysis-and-suggestions-of-initial-survey
#9
Esther Diana Rossi, William C Faquin, Zubair Baloch, Güliz A Barkan, Maria Pia Foschini, Marc Pusztaszeri, Philippe Vielh, Daniel F I Kurtycz
BACKGROUND: An international panel of experts in the field of salivary gland cytology (SGC), supported by the American Society of Cytopathology (ASC) and the International Academy of Cytology, conducted a survey to seek evidence and practice patterns regarding SGC. Results were used to provide focus for the proposed Milan System for Reporting Salivary Gland Cytopathology. METHODS: The study group, formed during the 2015 European Congress of Cytology held in Milan, Italy, generated a survey that included 49 specific questions related to the taxonomies, practices, and diagnostic entities of salivary cytology...
July 14, 2017: Cancer
https://www.readbyqxmd.com/read/28701825/role-of-cell-block-in-cytopathologic-evaluation-of-image-guided-fine-needle-aspiration-cytology
#10
Elizabath P Mathew, Vijayalakshmi Nair
CONTEXT: Fine needle aspiration cytology (FNAC) of superficial or deep-seated lesion is an increasingly common practice, eliminating time consuming and costly diagnostic procedures and providing rapid and safe diagnosis. AIMS: To assess utility of cell block preparation method in increasing sensitivity of cytodiagnosis in deep-seated image-guided FNACs. SETTINGS AND DESIGN: This was a hospital-based observational study conducted in the Department of Pathology, over a period of one and a half years...
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28701706/intraoperative-frozen-section-can-be-reduced-in-thyroid-nodules-classified-as-bethesda-categories-v-and-vi
#11
Jing Huang, Jieli Luo, Jianshe Chen, Yang Sun, Chao Zhang, Kanlun Xu, Qin Ye, Pintong Huang
Intraoperative frozen section (FS) can be reduced during thyroid lobectomy according to the results of fine needle aspiration (FNA). We evaluated the role of intraoperative FS in thyroid nodules with different diagnostic categories of the Bethesda System for Reporting Thyroid Cytopathology by FNA. This retrospective study included 1,235 nodules collected via thyroidectomy with both preoperative FNA and intraoperative FS at the Second Affiliated Hospital of Zhejiang University School of Medicine, from January 2011 to January 2014...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696007/comparison-of-conventional-cytology-and-surepath-in-split-thyroid-fine-needle-aspiration-materials
#12
D Sahin, D Yilmazbayhan, P Firat, U P Hacisalihoglu, S H Kirimlioglu, E Celenk, R Arslan
OBJECTIVE: The aim of the present study was to compare the cytomorphological features and cytopathological diagnoses in thyroid aspiration materials prepared by SurePath® (SP) and conventional cytology (CC). MATERIALS AND METHODS: Fine needle aspiration (FNA) materials from 180 thyroid nodules were divided into two groups to prepare three conventional smears and one SP slide. Twenty-nine cytomorphological features of thyroid lesions were compared in the CC and SP slides...
July 11, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28693006/two-fortuitous-papers-in-1917-that-conceived-diagnostic-cytopathology
#13
Nikolaos Chantziantoniou
No abstract text is available yet for this article.
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28670850/cystic-major-salivary-gland-lesions-utilizing-fine-needle-aspiration-to-optimize-the-clinical-management-of-a-broad-and-diverse-differential-diagnosis
#14
Derek B Allison, Austin M McCuiston, Satomi Kawamoto, David W Eisele, Justin A Bishop, Zahra Maleki
INTRODUCTION: The use of fine-needle aspiration (FNA) cytology for the preoperative evaluation of salivary gland lesions is an accepted but, currently, nonstandardized practice. More specifically, cystic major salivary gland lesions are relatively rare and can be very challenging to diagnose on FNA due to low cellularity and an incredibly broad differential diagnosis. The purpose of this study was to investigate the diagnostic utility of preoperative FNA cytology for cystic major salivary gland lesions...
July 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28652923/jc-virus-granule-cell-neuronopathy-onset-two-months-after-chemotherapy-for-low-grade-lymphoma
#15
Kathryn B Holroyd, Elias S Sotirchos, Scott R DeBoer, Kelly A Mills, Scott D Newsome
BACKGROUND: Granule cell neuronopathy (GCN) is a rare disease caused by the JC virus, leading to degeneration of cerebellar granule cell neurons. Primarily described in patients with AIDS, it has also been diagnosed in patients with lymphoproliferative diseases and after long-term treatment with immune-suppressing medications such as natalizumab. CASE PRESENTATION: A 69 year old woman presented with progressive ataxia which began 2 months after initiation of treatment for follicular low-grade B cell lymphoma with rituximab/bendamustine, and progressed for 2 years prior to admission...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/28626115/reappraisal-of-cyst-fluid-only-on-thyroid-fine-needle-aspiration-cytology
#16
Nami Takada, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Akira Miyauchi
According to the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), cyst fluid only (CFO) cases are classified in the non-diagnostic category. To date, no large study focusing on CFO has been conducted. To reassess the diagnostic significance of CFO, we compared CFO nodules with non-diagnostic nodules excluding CFO (ND-other). We reviewed the conventional thyroid smears of 715 CFO and 766 ND-other nodules. We compared the timing of and findings at re-aspiration, the histology of resected specimens, and the proportion of malignant nodules between the two groups...
June 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28624647/comparing-endoscopic-ultrasound-fine-needle-aspiration-and-endoscopic-ultrasound-fine-needle-biopsy-for-solid-lesions-a%C3%A2-multicenter-randomized-trial-the-new-york-endoscopic-research-outcomes-group-nyero
#17
Satish Nagula, Kamron Pourmand, Harry Aslanian, Juan Carlos Bucobo, Tamas Gonda, Susana Gonzalez, Adam Goodman, Seth A Gross, Sammy Ho, Christopher J DiMaio, Michelle Kim, Shireen Pais, John Poneros, David Robbins, Felice Schnoll-Sussman, Amrita Sethi, Jonathan M Buscaglia
BACKGROUND & AIMS: Endoscopic ultrasound with fine-needle aspiration (FNA) is the standard of care for tissue sampling of solid lesions adjacent to the gastrointestinal tract. Fine-needle biopsy (FNB) may provide higher diagnostic yield with fewer needle passes. The aim of this study was to assess the difference in diagnostic yield between FNA and FNB. METHODS: This is a multicenter, prospective randomized clinical trial from 6 large tertiary care centers. Patients referred for tissue sampling of solid lesions were randomized to either FNA or FNB of the target lesion...
June 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28609008/analytic-inquiry-validation-and-practical-considerations
#18
Anna B Berry
Molecular diagnostics and cytopathology ideally are complementary medical services. When used together, they provide optimal benefit to patient care with the least risk of complications. However, many cytopathology laboratories are reluctant to bring in molecular tests, in part due to inexperience with regard to molecular test validation. This article is a brief review of the basic principles of molecular test validation as it applies to cytopathology samples. Regulatory constraints, practical considerations, and issues that are particular to cytopathology samples are discussed, along with a brief review of issues that pertain specifically to next-generation sequencing...
June 2017: Cancer
https://www.readbyqxmd.com/read/28609000/the-role-of-informatics-in-patient-centered-care-and-personalized-medicine
#19
Matthew G Hanna, Liron Pantanowitz
The practice of cytopathology has dramatically changed due to advances in genomics and information technology. Cytology laboratories have accordingly become increasingly dependent on pathology informatics support to meet the emerging demands of precision medicine. Pathology informatics deals with information technology in the laboratory, and the impact of this technology on workflow processes and staff who interact with these tools. This article covers the critical role that laboratory information systems, electronic medical records, and digital imaging plays in patient-centered personalized medicine...
June 2017: Cancer
https://www.readbyqxmd.com/read/28590047/cytopathologic-findings-of-cell-block-materials-from-the-vitreous-diagnostic-distinction-between-intraocular-lymphoma-and-non-lymphomatous-diseases
#20
Hiromi Kanno-Okada, Emi Takakuwa, Yoshiaki Tagawa, Satoru Kase, Kanako C Hatanaka, Yutaka Hatanaka, Kenichi Namba, Tomoko Mitsuhashi, Yoshihiro Matsuno
Intraocular lymphoma is a rare neoplasm that occurs only in the eyes and/or central nervous system. Diagnosis of intraocular lymphoma is difficult because its clinical manifestations mimic chronic uveitis. Pathological examination of the vitreous is one of the main diagnostic tools for intraocular lymphoma, but this is challenging due to the sparse cellularity and specimen degeneration. Here, we reviewed 33 cell block preparations from vitreous perfusion fluid in order to examine the significance of cytopathological findings for differential diagnosis using vitreous samples...
June 7, 2017: Pathology International
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