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diagnostic cytopathology

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https://www.readbyqxmd.com/read/29422426/the-presence-of-papillary-features-in-thyroid-nodules-diagnosed-as-atypia-of-undetermined-significance-or-follicular-lesion-of-undetermined-significance-increases-cancer-risk-and-should-influence-treatment
#1
Jean L Oosthuizen, Blair Walker, Emilija Todorovic, Hamid Masoudi, Sam M Wiseman
BACKGROUND: The objective of this study was to evaluate the influence of papillary features on risk of malignancy (ROM) within the Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance (AUS-FLUS) Bethesda System for Reporting Thyroid Cytopathology (BSRTC) diagnostic category. METHODS: A Retrospective review of cases with an AUS-FLUS diagnosis that underwent a thyroidectomy was carried out, and cases were subcategorized based upon the presence of papillary features...
January 5, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29412881/cytopathology-in-low-medical-infrastructure-countries-why-and-how-to-integrate-to-capacitate-health-care
#2
REVIEW
Andrew S Field
Fine-needle aspiration cytology is a rapid, accurate, minimally invasive, inexpensive biopsy technique requiring minimal laboratory infrastructure and proceduralist costs. It provides infectious and noncommunicable disease diagnoses and will play an essential role in the establishment of cancer services in low-income and middle-income countries (LMICs). The use of molecular and other ancillary tests on cytology material is rapidly expanding in high-income countries and will spread to LMICs. Establishing cytology services requires increased training of cytopathologists and cytotechnologists, increased education of clinicians in the use of diagnostic cytopathology, and commitment and funding from governments and specialist training groups...
March 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29412351/assessment-of-the-production-of-cervical-cancer-care-procedures-in-the-brazilian-national-health-system-in-2015
#3
Caroline Madalena Ribeiro, Gulnar Azevedo E Silva
OBJECTIVE: to assess the procedures production of screening, diagnostic investigation and precursor lesions treatment for cervical cancer in the Brazilian National Health System (SUS). METHODS: normative evaluation with calculation of estimates of need based on national screening guidelines in two scenarios: organized (1) and opportunistic (2) screening; data were obtained from the SUS Ambulatory Care Information System and the Cervical Cancer Information System...
February 1, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29403217/cytopathological-examination-of-bronchoalveolar-lavage-fluid-in-diagnosis-of-pulmonary-alveolar-proteinosis
#4
Manjari Kishore, Manju Kaushal, Desh Deepak, Manju Kumari
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the deposition of extracellular lipoproteinaceous material within the air spaces. Although the diagnosis is mainly based on histopathological findings, sometimes, the diagnostic yield of transbronchial and even open lung biopsy can be unsatisfactory. The advantage with bronchoalveolar lavage (BAL) cytology is that apart from being safer for the patient, it can sample a much wider area and help in giving an early diagnosis and treatment to the patient...
January 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29403167/reproducibility-of-the-bethesda-system-for-reporting-thyroid-cytopathology-a-retrospective-analysis-of-107-patients
#5
Pragati Awasthi, Garima Goel, Ujjawal Khurana, Deepti Joshi, Kaushik Majumdar, Neelkamal Kapoor
Objectives: Fine-needle aspiration cytology (FNAC) has emerged as an indispensable tool to discriminate thyroid lesions into benign or malignant for appropriate management. The need for simplicity of communication and standardization of terminology for thyroid FNAC reporting led to introduction of "The Bethesda system for reporting Thyroid Cytopathology" (TBSRTC) in a conference held at the National Cancer Institute in 2007. This study aims at establishing the reproducibility of TBSRTC for diagnosing thyroid lesions...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29401169/per-pass-performance-characteristics-of-endoscopic-ultrasound-guided-fine-needle-aspiration-of-malignant-solid-pancreatic-masses-in-a-large-multicenter-cohort
#6
Phillip S Ge, Sachin Wani, Rabindra R Watson, Alireza Sedarat, Stephen Kim, Carrie Marshall, Robert H Wilson, Jitin Makker, Mehdi Mohamadnejad, Srinadh Komanduri, V Raman Muthusamy
OBJECTIVES: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is widely performed for the evaluation of pancreatic masses. We evaluated the performance characteristics of EUS-FNA in obtaining a diagnosis of pancreatic malignancy. METHODS: We performed a multicenter study of patients who underwent EUS-FNA for a solid pancreatic mass. Endoscopic ultrasound-guided FNA was standardized using a 25-gauge needle, slow-pull stylet technique for specimen acquisition, and on-site cytopathology...
February 2, 2018: Pancreas
https://www.readbyqxmd.com/read/29383316/solitary-head-and-neck-cysticercosis-a-series-of-rare-cases
#7
Priyanko Chakraborty, Rakhi Kumari, Rajiv-Kumar Jain, Vikash Prasad, Sidharth Pradhan, Purnima Joshi
Introduction: Cysticercosis is a disease which is caused by the infestation of the larvae Taenia solium, with humans acting as an intermediate host instead of a definitive host. Head and neck involvement including maxillofacial and oral involvement of cysticercosis is quite rare. Case Report: We report a series of rare cases of cysticercosis of the head and neck region encountered in a tertiary hospital in Northern India with a brief review of literature and its diagnosis and management...
November 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29372844/molecular-testing-of-non-small-cell-lung-carcinoma-diagnosed-by-endobronchial-ultrasound-guided-transbronchial-fine-needle-aspiration
#8
Erika E Doxtader, Yu-Wei Cheng, Yaxia Zhang
CONTEXT: - Given the increasing demand for molecular testing of non-small cell lung carcinoma specimens to guide therapeutic decision-making, and the trend toward minimally invasive techniques for obtaining diagnostic tissue, cytopathology laboratories must devise strategies to maximize DNA yield for necessary molecular testing. OBJECTIVE: - To describe our experience at Cleveland Clinic with epidermal growth factor receptor ( EGFR) mutation testing by next-generation sequencing and anaplastic lymphoma kinase ( ALK) gene rearrangement testing by fluorescence in situ hybridization of non-small cell lung carcinomas diagnosed by cytology, with an emphasis on specimens obtained by endobronchial ultrasound-guided transbronchial fine-needle aspiration...
January 26, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29356393/improvement-of-diagnostic-performance-of-pathologists-by-reducing-the-number-of-pathologists-responsible-for-thyroid-fine-needle-aspiration-cytology-an-institutional-experience
#9
Jae Yeon Seok, Jungsuk An, Hyun Yee Cho
BACKGROUND: Various efforts have been made to improve the diagnostic accuracy of thyroid fine needle aspiration (FNA) cytology. We changed the diagnostic system by reducing the number of pathologists responsible for the thyroid FNA cytology in the routine work, and analyzed the effect on the pathologist's diagnostic performance. METHODS: Since March 1, 2015, 3 pathologists have been responsible for diagnostic thyroid FNA, previously undertaken by 9 equally. We compared the prechange period (three months, 319 nodules) and the postchange period (12 months, 1194 nodules)...
January 22, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29346217/pathological-and-molecular-aspects-to-improve-endoscopic-ultrasonography-guided-fine-needle-aspiration-from-solid-pancreatic-lesions
#10
Hiroyuki Matsubayashi, Keiko Sasaki, Sachiyo Ono, Masato Abe, Hirotoshi Ishiwatari, Akira Fukutomi, Katsuhiko Uesaka, Hiroyuki Ono
Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has been applied to pancreatic lesions since the 1990s, and its use is now widespread. Improvements in endoscopic devices and sampling techniques have resulted in excellent diagnostic ability for solid pancreatic lesions. However, clinical improvements alone are not responsible for it; pathological aspects have also played important roles. Rapid on-site evaluation minimizes endoscopic procedures, although its value at improving the diagnostic ratio is still debated...
February 2018: Pancreas
https://www.readbyqxmd.com/read/29332654/evaluation-of-loop-mediated-isothermal-amplification-lamp-assay-in-the-diagnosis-of-tubercular-lymphadenitis-a-pilot-study
#11
Baijayantimala Mishra, Vinaykumar Hallur, Bijayini Behera, C Preetam, Priti Nanda Mishra, Jyotirmayee Turuk, Prasanta Raghab Mohapatra
Tubercular lymphadenitis (TBLA) contributes to 30-40% of extrapulmonary TB cases in the immunocompetent individuals and 40-50% in people with HIV. Current diagnostic methods for TBLA like Gene-Xpert or PCR are costly and conventional methods like fine needle aspiration cytology, histopathology lack sensitivity and specificity. Culture which is considered as gold standard require high turnaround time. Loop mediated isothermal amplification (LAMP) assay has been developed as a novel technique for nucleic acid amplification and has shown promising results in the diagnosis of pulmonary tuberculosis...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29328776/more-than-a-decade-of-molecular-diagnostic-cytopathology-leading-diagnostic-and-therapeutic-decision-making
#12
Manuel Salto-Tellez
No abstract text is available yet for this article.
January 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29316304/the-paris-system-for-reporting-urinary-cytology-improves-correlation-with-surgical-pathology-biopsy-diagnoses-of-the-lower-urinary-tract
#13
Elizabeth C Bertsch, Momin T Siddiqui, Carla L Ellis
INTRODUCTION: The current study seeks to compare both the original diagnoses (OD) and the updated Paris system diagnoses (PD) of urinary cytology specimens to the corresponding surgical pathology (biopsy) diagnoses (SD) to determine which diagnostic paradigm (OD vs PD) has a stronger correlation to the SD. DESIGN: 56 cases from 34 patients that had a malignant SD associated with a corresponding cytology specimen from the same location within up to 90 days of the biopsy procedure were selected...
January 8, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29306252/the-diagnostic-accuracy-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-in-mediastinal-tuberculous-lymphadenitis
#14
Onur Fevzi Erer, Serhat Erol, Ceyda Anar, Can Biçmen, Zekiye Aydoğdu, Serir Aktoğu
Background/aim: Mediastinal lymph nodes are the second most commonly affected lymph nodes in tuberculous lymphadenitis. It is often difficult to diagnose tuberculosis in patients with lymphadenopathy without parenchymal lesions. The aim of this study was to describe the diagnostic utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with isolated mediastinal tuberculous lymphadenitis (MTLA). Materials and methods: This study included 527 patients who had undergone EBUS-TBNA between December 2012 and December 2014...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29278433/molecular-testing-for-thyroid-nodules-review-and-current-state
#15
REVIEW
Mara Y Roth, Robert L Witt, David L Steward
Thyroid nodules affect nearly two-thirds of the world population. Fine-needle biopsy with cytologic evaluation remains the diagnostic test of choice to distinguish benign from malignant thyroid nodules yet fails to discriminate as benign or malignant in up to one-third of cases. This review discusses the limitation of current cytopathologic evaluation, the development of thyroid molecular testing, and the strengths and limitations of commercially available tests. Initial cytomolecular testing sought to identify specific gene mutations associated with thyroid cancer...
December 26, 2017: Cancer
https://www.readbyqxmd.com/read/29259654/a-case-of-large-cell-neuroendocrine-carcinoma-of-the-uterine-cervix-misdiagnosed-as-adenocarcinoma-in-thinprep-cytology-test
#16
Jong-Hee Nam, Jongin Na, Nah-Ihm Kim, Ga-Eon Kim, Chang-Soo Park, Yoo-Duk Choi
Large cell neuroendocrine carcinoma (LCNEC) of uterine cervix is a rare malignancy with aggressive behavior and poor clinical outcome even in its early stage. Few cytopathologic features of cervical LCNEC have been reported previously. A 57-year-old postmenopausal African American female, presented to the local health department with a chief complaint of heavy vaginal bleeding. A 45-year-old female presented with 20 months of vaginal pruritus and foul odor. Cervical malignancy was suspected by pelvis magnetic resonance imaging...
2017: CytoJournal
https://www.readbyqxmd.com/read/29237960/spritzer-for-diagnostic-cytopathology
#17
Rashmi Metgud, Smitha Naik, Shrikant Patel
BACKGROUND: Exfoliative cytology is an easy, economical, noninvasive, and feasible method for early detection and screening program of any premalignant or malignant lesion. In case of routine cytological procedure, classical Papanicolaou (PAP) stain is widely used while Romanowsky stains are sparingly used. Leishman-Giemsa (LG) cocktail, being a easier, cost effective staining technique, has not been used in exfoliative cytology. Therefore, this pilot study was carried out to compare and contrast the role of LG stain in routine cytological procedure which is very cost-effective, less time-consuming and requires less infrastructural support...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29221292/a-comparative-study-of-conventional-cytology-and-cell-block-method-in-the-diagnosis-of-pleural-effusion
#18
Theerada Assawasaksakul, Viboon Boonsarngsuk, Pimpin Incharoen
Background: In a patient with pleural effusion, cytological study (CS) is one of the most useful investigations, especially when malignancy is suspected. Instead of applying only CS, the pleural fluid can be further processed using the cell block (CB) technique, which may augment the diagnostic utility. The aim of this study was to compare the diagnostic yields of CS, CB, and the combination of both, regardless of the etiology of pleural effusion. Methods: A cross-sectional study was conducted on patients with pleural effusions who underwent thoracentesis from June 2015 to May 2016...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218619/cervical-ultrasonography-has-no-additional-value-over-negative-18f-fdg-pet-ct-scans-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-oesophageal-cancer
#19
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVES: To investigate the additional value of cervical ultrasonography over 18F-FDG PET/CT for diagnosing cervical lymph node metastases in patients with newly diagnosed oesophageal cancer. METHODS: Between January 2013 and January 2016, 163 patients with newly diagnosed oesophageal cancer underwent both cervical ultrasonography and 18F-FDG PET/CT at a tertiary referral centre in the Netherlands. Retrospective clinical data analysis was performed to assess the diagnostic value of cervical ultrasonography and 18F-FDG PET/CT for the detection of cervical lymph node metastases...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29193839/implementing-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-may-potentially-impact-the-risk-of-malignancy-for-thyroid-nodules-categorized-as-aus-flus-and-fn-sfn
#20
Weihong Li, Andrew Sciallis, Madelyn Lew, Judy Pang, Xin Jing
BACKGROUND: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Implementation of the new terminology may alter the implied risk of malignancy (ROM) across the six categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). METHODS: The study cohort consisted of thyroid fine needle aspiration (FNA) cases which were assessed between January 2011 and June 2016 and led to surgical resections...
November 30, 2017: Diagnostic Cytopathology
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