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diagnostic cytopathology

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https://www.readbyqxmd.com/read/29221292/a-comparative-study-of-conventional-cytology-and-cell-block-method-in-the-diagnosis-of-pleural-effusion
#1
Theerada Assawasaksakul, Viboon Boonsarngsuk, Pimpin Incharoen
Background: In a patient with pleural effusion, cytological study (CS) is one of the most useful investigations, especially when malignancy is suspected. Instead of applying only CS, the pleural fluid can be further processed using the cell block (CB) technique, which may augment the diagnostic utility. The aim of this study was to compare the diagnostic yields of CS, CB, and the combination of both, regardless of the etiology of pleural effusion. Methods: A cross-sectional study was conducted on patients with pleural effusions who underwent thoracentesis from June 2015 to May 2016...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218619/cervical-ultrasonography-has-no-additional-value-over-negative-18f-fdg-pet-ct-scans-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-oesophageal-cancer
#2
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVES: To investigate the additional value of cervical ultrasonography over 18F-FDG PET/CT for diagnosing cervical lymph node metastases in patients with newly diagnosed oesophageal cancer. METHODS: Between January 2013 and January 2016, 163 patients with newly diagnosed oesophageal cancer underwent both cervical ultrasonography and 18F-FDG PET/CT at a tertiary referral centre in the Netherlands. Retrospective clinical data analysis was performed to assess the diagnostic value of cervical ultrasonography and 18F-FDG PET/CT for the detection of cervical lymph node metastases...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29193839/implementing-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-may-potentially-impact-the-risk-of-malignancy-for-thyroid-nodules-categorized-as-aus-flus-and-fn-sfn
#3
Weihong Li, Andrew Sciallis, Madelyn Lew, Judy Pang, Xin Jing
BACKGROUND: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Implementation of the new terminology may alter the implied risk of malignancy (ROM) across the six categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). METHODS: The study cohort consisted of thyroid fine needle aspiration (FNA) cases which were assessed between January 2011 and June 2016 and led to surgical resections...
November 30, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29193477/outcomes-of-endoscopic-ultrasound-guided-pancreatic-fnac-diagnosis-for-solid-and-cystic-lesions-at-manchester-royal-infirmary-based-upon-the-papanicolaou-society-of-cytopathology-pancreaticobiliary-terminology-classification-scheme
#4
P K Wright, D A Shelton, M R Holbrook, S A Thiryayi, N Narine, D Slater, D N Rana
OBJECTIVE: To compare endoscopic ultrasound (EUS)-FNAC diagnosis of pancreatic lesions with patient outcome based upon the Papanicolaou Society of Cytopathology pancreaticobiliary terminology classification scheme diagnostic categories: Panc 1 (non-diagnostic); Panc 2 (negative for malignancy/neoplasia); Panc 3 (atypical); Panc 4B (neoplastic, benign); Panc 4O (neoplastic, other); Panc 5 (suspicious of malignancy); and Panc 6 (positive/malignant). METHODS: All EUS-FNA pancreas specimens taken at Manchester Royal Infirmary in 2015 were prospectively classified according to the above scheme at the time of cytology reporting and data recorded prospectively...
November 29, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29187888/advantage-of-pet-ct-in-target-delineation-of-mri-negative-cervical-lymph-nodes-in-intensity-modulated-radiation-therapy-planning-for-nasopharyngeal-carcinoma
#5
Guanzhu Shen, Weiwei Xiao, Fei Han, Wei Fan, Xiao-Ping Lin, Lixia Lu, Lie Zheng, Ning Yue, Bruce Haffty, Chong Zhao, Xiaowu Deng
Introduction: In intensity-modulated radiation therapy (IMRT) planning for nasopharyngeal carcinoma (NPC), cervical lymph nodes (CLNs) that appear negative on magnetic resonance imaging (MRI) scans can be difficult to target. The purpose of this study was to assess the advantage of 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET/CT) for distinguishing MRI-negative CLNs and the effect of 18F-FDG PET/CT on diagnosis, target delineation, and dose prescription in IMRT planning for NPC...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29183021/digital-applications-in-cytopathology-problems-rationalizations-and-alternative-approaches
#6
Nikolaos Chantziantoniou, Maheswari Mukherjee, Amber D Donnelly, Liron Pantanowitz, R Marshall Austin
OBJECTIVE: The aim of this work was to raise awareness of problems using digital applications for examining, teaching, and applying telecytology at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia; University of Nebraska Medical Center (UNMC), Omaha, NE, USA; and University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA. The objective was to rationalize problems and propose alternative digital approaches. STUDY DESIGN: We sought to identify solutions to improve the following: (a) interpretive examination scores at KAMC for complex cytological templates (i...
November 29, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/29161789/current-status-of-thyroid-fine-needle-aspiration-practice-in-thailand
#7
REVIEW
Somboon Keelawat, Samreung Rangdaeng, Supinda Koonmee, Tikamporn Jitpasutham, Andrey Bychkov
Thyroid carcinoma is one of the leading malignancies in Thailand increasingly prevalent in the female population. Fine-needle aspiration (FNA) cytology is a widely used diagnostic tool for evaluation of thyroid nodules and thyroid cancer. Thyroid FNA is a routine procedure universally performed in Thai hospitals by a variety of clinical specialists. Manual guidance is the first-line choice complemented by ultrasound assistance in selected cases. Despite national guidelines recommendations, the diagnostic criteria and terminology of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was slowly adopted in the local settings...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29131530/biomarkers-for-immune-checkpoint-inhibitors-the-importance-of-tumor-topography-and-the-challenges-to-cytopathology
#8
REVIEW
Douglas P Clark
The recent emergence of immune checkpoint inhibitors for cancer therapy has created much excitement among cancer patients, drug and diagnostic developers, and health care professionals. This is due largely to the dramatic and sustained responses among some advanced cancers that were previously refractory to therapy. Unfortunately, these responses are difficult to predict, so the goal of the right drug for the right patient at the right time remains elusive. This is in part due to the complexity of the tumor immune microenvironment and its role in drug efficacy...
November 13, 2017: Cancer
https://www.readbyqxmd.com/read/29118474/cytological-evaluation-of-thyroid-lesions-by-nuclear-morphology-and-nuclear-morphometry
#9
R Yashaswini, T N Suresh, A Sagayaraj
Introduction: Fine needle aspiration (FNA) of the thyroid gland is an effective diagnostic method. The Bethesda system for reporting thyroid cytopathology classifies them into six categories and gives implied risk for malignancy and management protocol in each category. Though the system gives specific criteria, diagnostic dilemma still exists. Using nuclear morphometry, we can quantify the number of parameters, such as those related to nuclear size and shape. The evaluation of nuclear morphometry is not well established in thyroid cytology...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29115040/telecytology-is-it-possible-with-smartphone-images
#10
Davut Sahin, Uguray Payam Hacisalihoglu, Saime Hale Kirimlioglu
INTRODUCTION: This study aimed to discuss smartphone usage in telecytology and determine intraobserver concordance between microscopic cytopathological diagnoses and diagnoses derived via static smartphone images. METHODS: The study was conducted with 172 cytologic material. A pathologist captured static images of the cytology slides from the ocular lens of a microscope using a smartphone. The images were transferred via WhatsApp® to a cytopathologist working in another center who made all the microscopic cytopathological diagnoses 5-27 months ago...
November 8, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29099902/correlation-between-the-fceai-and-diagnostic-parameters-in-chronic-enteropathies-in-147-cats-2006-2012
#11
Stefanie Mitze, Katharina Moser, Erik Teske, Wolf V Bomhard, Christian Stockhaus
OBJECTIVE: The Feline Chronic Enteropathy Activity Index (FCEAI) has been established as a quantitative index for disease activity in chronic enteropathies in cats. A definite diagnosis is aimed at histology with initial exclusion of extraintestinal causes by laboratory examinations, diagnostic imaging and endoscopy. The study aimed to examine diagnostic parameters and FCEAI in chronic gastroenteropathies. MATERIALS AND METHODS: A retrospective case review of 147 cats with chronic enteropathies was performed...
November 3, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/29091573/the-2017-bethesda-system-for-reporting-thyroid-cytopathology
#12
Edmund S Cibas, Syed Z Ali
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) established a standardized, category-based reporting system for thyroid fine-needle aspiration (FNA) specimens. The 2017 revision reaffirms that every thyroid FNA report should begin with one of six diagnostic categories, the names of which remain unchanged since they were first introduced: (i) nondiagnostic or unsatisfactory; (ii) benign; (iii) atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS); (iv) follicular neoplasm or suspicious for a follicular neoplasm; (v) suspicious for malignancy; and (vi) malignant...
November 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29075565/assisting-the-neurologist-in-diagnosis-of-cns-malignancies-current-possibilities-and-limits-of-cerebrospinal-fluid-cytology-and-immunocytochemistry
#13
Jaroslava Dušková, Ondřej Sobek
OBJECTIVES: In tumorous impairment of CNS, cytological identification of the neoplastic cells in CSF frequently requires the use of ancillary techniques. Our methods are focused on identifying algorithms that increase the probability of identifying CSF malignant cells. MATERIALS AND METHODS: A total of 1.272 CSF samples from patients with tumorous infiltration of CNS of nonhematologic origin along with 721 samples from patients with hematologic malignancies were analyzed in a complex setting including cytological and immunocytochemical investigations...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29073758/the-use-of-fine-needle-aspiration-fna-cytology-in-patients-with-thyroid-nodules-in-asia-a-brief-overview-of-studies-from-the-working-group-of-asian-thyroid-fna-cytology
#14
REVIEW
Chan Kwon Jung, SoonWon Hong, Andrey Bychkov, Kennichi Kakudo
Ultrasound-guided fine-needle aspiration (FNA) cytology is the most widely used screening and diagnostic method for thyroid nodules. Although Western guidelines for managing thyroid nodules and the Bethesda System for Reporting Thyroid Cytopathology are widely available throughout Asia, the clinical practices in Asia vary from those of Western countries. Accordingly, the Working Group of Asian Thyroid FNA Cytology encouraged group members to publish their works jointly with the same topic. The articles in this special issue focused on the history of thyroid FNA, FNA performers and interpreters, training programs of cytopathologists and cytotechnicians, staining methods, the reporting system of thyroid FNA, quality assurance programs, ancillary testing, and literature review of their own country's products...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29071277/ebus-tbna-in-pet-positive-lymphadenopathies-in-treated-cancer-patients
#15
Juliana Guarize, Monica Casiraghi, Stefano Donghi, Chiara Casadio, Cristina Diotti, Niccolò Filippi, Clementina Di Tonno, Valeria Midolo, Patrick Maisonneuve, Daniela Brambilla, Chiara Maria Grana, Francesco Petrella, Lorenzo Spaggiari
Mediastinal lymph node enlargement is common in the follow-up of patients with previously treated malignancies. The aim of this study is to assess the role of endobronchial ultrasound (EBUS) transbronchial needle aspiration (TBNA) for cyto-histological evaluation of positron emission tomography with (18)fluorodeoxyglucose (PET) positive mediastinal and hilar lymph nodes developed in patients with previous malignancies. All EBUS-TBNA cases performed from January 2012 to May 2016 were retrospective reviewed. Results of EBUS-TBNA in patients with mediastinal and/or hilar lymphadenopathies were analysed...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29063636/presence-of-cancer-cells-in-gastric-lavage-of-gastric-cancer-patients-as-an-indicator-of-advanced-disease-predictor-of-tumour-aggressive-phenotype-and-independent-prognostic-factor-for-poor-survival-the-endoluminal-metastatic-pathway-of-gastric-cancer-and-gl0
#16
E Virgilio, E Giarnieri, M R Giovagnoli, M Montagnini, A Proietti, R D'Urso, G Nigri, P Mercantini, G Ramacciato, M Cavallini, G Balducci
OBJECTIVE: As of 2017, the pathobiology of gastric cancer (GC) is far from fully understood; consequently, new methods of basic and advanced research have been proposed and tested. The presence (GL1) vs absence (GL0) of malignant cells exfoliated in gastric lavage (GL) of GC patients was formerly evaluated with diagnostic intent but not for staging or prognostic assessment. We investigated this hitherto unreported application of cytopathology. METHODS: GL was preoperatively and prospectively collected from 80 GC patients and cytologically analysed...
October 23, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29048220/performance-characteristics-of-body-fluid-cytology-analysis-of-344%C3%A2-380-responses-from-the-college-of-american-pathologists-interlaboratory-comparison-program-in-nongynecologic-cytopathology
#17
Z Laura Tabatabai, Ritu Nayar, Rhona J Souers, Barbara A Crothers, Diane Davis Davey
CONTEXT: - Body fluid cytology is an important diagnostic tool used to identify various conditions. However, an accurate diagnosis in this setting can sometimes be challenging. OBJECTIVE: - To identify the performance characteristics of body fluid cytology by analyzing participant responses from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology. DESIGN: - Participant responses from 5102 slides were analyzed for concordance to the general category (GC) and to the reference diagnosis (RD)...
October 19, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29034595/adamantinoma-like-ewing-sarcoma-of-the-parotid-gland-cytopathologic-findings-and-differential-diagnosis
#18
Mohammed T Lilo, Justin A Bishop, Matthew T Olson, Syed Z Ali
Adamantinoma-like Ewing sarcoma (AES) is a rare variant of Ewing sarcoma family of tumors (EFTs), primarily affecting bone and soft tissue. AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with a complex immunoprofile and EWSR1 gene rearrangements. Herein, we report a 72-year-old male who presented with left parotid mass, right neck mass and thyroid nodules. Fine needle aspiration of the left parotid mass displayed nests of monotonous epithelioid cells with basaloid features in a background of small round blue cells and lymphocytes...
October 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29027030/diagnostic-accuracy-of-fungal-identification-in-histopathology-and-cytopathology-specimens
#19
V L Kung, R D Chernock, C-A D Burnham
Tools to diagnose fungal infection are microscopic examination, antigen or antibody-based detection tests, molecular diagnostics, and culture, with culture being the "gold standard" for species-level identification. Although these methods are commonly used in concert and yield concordant results, in some cases tissue is not available for culture, and/or different methodologies yield discrepant results. These discrepancies may be clinically significant, causing confusion and inappropriate or delayed initiation of antifungals...
October 13, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29017315/thyroid-cytology-the-japanese-system-and-experience-at-yamashita-thyroid-hospital
#20
REVIEW
Shinya Satoh, Hiroyuki Yamashita, Kennichi Kakudo
In Japan, fine-needle aspiration (FNA) cytology is the most important diagnostic modality for triaging patients with thyroid nodules. A clinician (endocrinologist, endocrine surgeon, or head and neck surgeon) generally performs FNA cytology at the outpatient clinic, and ultrasound (US)-guided FNA is widespread because US is extremely common and most clinicians are familiar with it. Although almost all FNA thyroid samples are examined by certified cytopathologists and pathologists, some clinicians assess cytological specimens themselves...
November 2017: Journal of Pathology and Translational Medicine
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