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diagnostic cytopathology

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https://www.readbyqxmd.com/read/28718513/the-fine-needle-aspiration-of-translocation-sarcomas
#1
C J VandenBussche, C L Adams, O G McDonald, S A Whitworth, S Z Ali
INTRODUCTION: Soft tissue sarcomas comprise a heterogeneous group of clinically aggressive cancers that are often hard to classify on limited cytological samples. "Translocation sarcomas" (TS) are a diverse subset of such cancers, different from pleomorphic sarcomas, and characterised by unique single chromosomal translocations in each sarcoma subtype. Interestingly, despite their high-grade biological behaviour, TS have deceptively monotonous and bland cytomorphology, therefore creating diagnostic issues on limited samples...
July 17, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28708928/the-milan-system-for-reporting-salivary-gland-cytopathology-analysis-and-suggestions-of-initial-survey
#2
Esther Diana Rossi, William C Faquin, Zubair Baloch, Güliz A Barkan, Maria Pia Foschini, Marc Pusztaszeri, Philippe Vielh, Daniel F I Kurtycz
BACKGROUND: An international panel of experts in the field of salivary gland cytology (SGC), supported by the American Society of Cytopathology (ASC) and the International Academy of Cytology, conducted a survey to seek evidence and practice patterns regarding SGC. Results were used to provide focus for the proposed Milan System for Reporting Salivary Gland Cytopathology. METHODS: The study group, formed during the 2015 European Congress of Cytology held in Milan, Italy, generated a survey that included 49 specific questions related to the taxonomies, practices, and diagnostic entities of salivary cytology...
July 14, 2017: Cancer
https://www.readbyqxmd.com/read/28701825/role-of-cell-block-in-cytopathologic-evaluation-of-image-guided-fine-needle-aspiration-cytology
#3
Elizabath P Mathew, Vijayalakshmi Nair
CONTEXT: Fine needle aspiration cytology (FNAC) of superficial or deep-seated lesion is an increasingly common practice, eliminating time consuming and costly diagnostic procedures and providing rapid and safe diagnosis. AIMS: To assess utility of cell block preparation method in increasing sensitivity of cytodiagnosis in deep-seated image-guided FNACs. SETTINGS AND DESIGN: This was a hospital-based observational study conducted in the Department of Pathology, over a period of one and a half years...
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28701706/intraoperative-frozen-section-can-be-reduced-in-thyroid-nodules-classified-as-bethesda-categories-v-and-vi
#4
Jing Huang, Jieli Luo, Jianshe Chen, Yang Sun, Chao Zhang, Kanlun Xu, Qin Ye, Pintong Huang
Intraoperative frozen section (FS) can be reduced during thyroid lobectomy according to the results of fine needle aspiration (FNA). We evaluated the role of intraoperative FS in thyroid nodules with different diagnostic categories of the Bethesda System for Reporting Thyroid Cytopathology by FNA. This retrospective study included 1,235 nodules collected via thyroidectomy with both preoperative FNA and intraoperative FS at the Second Affiliated Hospital of Zhejiang University School of Medicine, from January 2011 to January 2014...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696007/comparison-of-conventional-cytology-and-surepath-in-split-thyroid-fine-needle-aspiration-materials
#5
D Sahin, D Yilmazbayhan, P Firat, U P Hacisalihoglu, S H Kirimlioglu, E Celenk, R Arslan
OBJECTIVE: The aim of the present study was to compare the cytomorphological features and cytopathological diagnoses in thyroid aspiration materials prepared by SurePath® (SP) and conventional cytology (CC). MATERIALS AND METHODS: Fine needle aspiration (FNA) materials from 180 thyroid nodules were divided into two groups to prepare three conventional smears and one SP slide. Twenty-nine cytomorphological features of thyroid lesions were compared in the CC and SP slides...
July 11, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28693006/two-fortuitous-papers-in-1917-that-conceived-diagnostic-cytopathology
#6
Nikolaos Chantziantoniou
No abstract text is available yet for this article.
July 11, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28670850/cystic-major-salivary-gland-lesions-utilizing-fine-needle-aspiration-to-optimize-the-clinical-management-of-a-broad-and-diverse-differential-diagnosis
#7
Derek B Allison, Austin M McCuiston, Satomi Kawamoto, David W Eisele, Justin A Bishop, Zahra Maleki
INTRODUCTION: The use of fine-needle aspiration (FNA) cytology for the preoperative evaluation of salivary gland lesions is an accepted but, currently, nonstandardized practice. More specifically, cystic major salivary gland lesions are relatively rare and can be very challenging to diagnose on FNA due to low cellularity and an incredibly broad differential diagnosis. The purpose of this study was to investigate the diagnostic utility of preoperative FNA cytology for cystic major salivary gland lesions...
July 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28652923/jc-virus-granule-cell-neuronopathy-onset-two-months-after-chemotherapy-for-low-grade-lymphoma
#8
Kathryn B Holroyd, Elias S Sotirchos, Scott R DeBoer, Kelly A Mills, Scott D Newsome
BACKGROUND: Granule cell neuronopathy (GCN) is a rare disease caused by the JC virus, leading to degeneration of cerebellar granule cell neurons. Primarily described in patients with AIDS, it has also been diagnosed in patients with lymphoproliferative diseases and after long-term treatment with immune-suppressing medications such as natalizumab. CASE PRESENTATION: A 69 year old woman presented with progressive ataxia which began 2 months after initiation of treatment for follicular low-grade B cell lymphoma with rituximab/bendamustine, and progressed for 2 years prior to admission...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/28626115/reappraisal-of-cyst-fluid-only-on-thyroid-fine-needle-aspiration-cytology
#9
Nami Takada, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Akira Miyauchi
According to the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), cyst fluid only (CFO) cases are classified in the non-diagnostic category. To date, no large study focusing on CFO has been conducted. To reassess the diagnostic significance of CFO, we compared CFO nodules with non-diagnostic nodules excluding CFO (ND-other). We reviewed the conventional thyroid smears of 715 CFO and 766 ND-other nodules. We compared the timing of and findings at re-aspiration, the histology of resected specimens, and the proportion of malignant nodules between the two groups...
June 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28624647/comparing-eus-fine-needle-aspiration-and-eus-fine-needle-biopsy-for-solid-lesions-a-multicenter-randomized-trial
#10
Satish Nagula, Kamron Pourmand, Harry Aslanian, Juan Carlos Bucobo, Tamas Gonda, Susana Gonzalez, Adam Goodman, Seth A Gross, Sammy Ho, Christopher J DiMaio, Michelle Kim, Shireen Pais, John Poneros, David Robbins, Felice Schnoll-Sussman, Amrita Sethi, Jonathan M Buscaglia
BACKGROUND & AIMS: Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) is the standard of care for tissue sampling of solid lesions adjacent to the GI tract. Fine needle biopsy (FNB) may provide higher diagnostic yield with fewer needle passes. The aim of this study was to assess the difference in diagnostic yield between FNA and FNB. METHODS: This is a multicenter, prospective randomized clinical trial from six large tertiary care centers. Patients referred for tissue sampling of solid lesions were randomized to either FNA or FNB of the target lesion...
June 14, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28609008/analytic-inquiry-validation-and-practical-considerations
#11
Anna B Berry
Molecular diagnostics and cytopathology ideally are complementary medical services. When used together, they provide optimal benefit to patient care with the least risk of complications. However, many cytopathology laboratories are reluctant to bring in molecular tests, in part due to inexperience with regard to molecular test validation. This article is a brief review of the basic principles of molecular test validation as it applies to cytopathology samples. Regulatory constraints, practical considerations, and issues that are particular to cytopathology samples are discussed, along with a brief review of issues that pertain specifically to next-generation sequencing...
June 2017: Cancer
https://www.readbyqxmd.com/read/28609000/the-role-of-informatics-in-patient-centered-care-and-personalized-medicine
#12
Matthew G Hanna, Liron Pantanowitz
The practice of cytopathology has dramatically changed due to advances in genomics and information technology. Cytology laboratories have accordingly become increasingly dependent on pathology informatics support to meet the emerging demands of precision medicine. Pathology informatics deals with information technology in the laboratory, and the impact of this technology on workflow processes and staff who interact with these tools. This article covers the critical role that laboratory information systems, electronic medical records, and digital imaging plays in patient-centered personalized medicine...
June 2017: Cancer
https://www.readbyqxmd.com/read/28590047/cytopathologic-findings-of-cell-block-materials-from-the-vitreous-diagnostic-distinction-between-intraocular-lymphoma-and-non-lymphomatous-diseases
#13
Hiromi Kanno-Okada, Emi Takakuwa, Yoshiaki Tagawa, Satoru Kase, Kanako C Hatanaka, Yutaka Hatanaka, Kenichi Namba, Tomoko Mitsuhashi, Yoshihiro Matsuno
Intraocular lymphoma is a rare neoplasm that occurs only in the eyes and/or central nervous system. Diagnosis of intraocular lymphoma is difficult because its clinical manifestations mimic chronic uveitis. Pathological examination of the vitreous is one of the main diagnostic tools for intraocular lymphoma, but this is challenging due to the sparse cellularity and specimen degeneration. Here, we reviewed 33 cell block preparations from vitreous perfusion fluid in order to examine the significance of cytopathological findings for differential diagnosis using vitreous samples...
June 7, 2017: Pathology International
https://www.readbyqxmd.com/read/28558124/comparison-of-glass-slides-and-various-digital-slide-modalities-for-cytopathology-screening-and-interpretation
#14
Matthew G Hanna, Sara E Monaco, Jacqueline Cuda, Juan Xing, Ishtiaque Ahmed, Liron Pantanowitz
BACKGROUND: Whole-slide imaging in cytology is limited when glass slides are digitized without z-stacks for focusing. Different vendors have started to provide z-stacking solutions to overcome this limitation. The Panoptiq imaging system allows users to create digital files combining low-magnification panoramic images with regions of interest (ROIs) that are imaged with high-magnification z-stacks. The aim of this study was to compare such panoramic images with conventional whole-slide images and glass slides for the tasks of screening and interpretation in cytopathology...
May 30, 2017: Cancer
https://www.readbyqxmd.com/read/28543000/fine-needle-aspiration-with-selective-use-of-core-needle-biopsy-of-major-salivary-gland-tumors
#15
Erica B Romano, Jason M Wagner, Anthony M Alleman, Lichao Zhao, Rachel D Conrad, Greg A Krempl
OBJECTIVES: Preferential use of fine-needle aspiration (FNA) versus core needle biopsy (CNB) for distinguishing benign from malignant major salivary gland tumors is highly debated. The main disadvantage of FNA is lower sensitivity, whereas arguments against CNB include use of a larger bore needle and greater risk of complications. The aim of this study is to evaluate our experience performing ultrasound-guided (UG) FNA with selective use of CNB based on preliminary cytopathology, and to determine whether our preoperative diagnostic approach is more sensitive and specific than FNA alone-and at least as sensitive and specific as CNB alone...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28511175/flexible-19-gauge-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-needle-first-experience
#16
Chung Tyan, Priya Patel, Kasia Czarnecka, Daniela Gompelmann, Ralf Eberhardt, Marc Fortin, Paul MacEachern, Christopher A Hergott, Elaine Dumoulin, Alain Tremblay, Samuel V Kemp, Pallav L Shah, Felix J F Herth, Kazuhiro Yasufuku
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established first-line invasive modality for mediastinal lymph node staging in lung cancer patients and in the diagnostic workup of patients with mediastinal adenopathy. With the current 21- and 22-gauge (G) EBUS-TBNA needles, the procedure can be limited by the degree of flexibility in the needle and the size of the lumen in tissue acquisition. OBJECTIVE: We report our initial experience with a first-generation flexible 19-G EBUS-TBNA (Flex 19G; Olympus Respiratory America, Redmond, WA, USA) needle with regards to efficacy and safety...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28506417/new-perspectives-in-the-diagnosis-of-thyroid-follicular-lesions
#17
REVIEW
Enke Baldini, Salvatore Sorrenti, Francesco Tartaglia, Antonio Catania, Andrea Palmieri, Daniele Pironi, Angelo Filippini, Salvatore Ulisse
Thyroid nodules are very common, affecting 19%-67% of the adult population. However, about 10% of them harbor a malignant lesion. Consequently, the first aim in their clinical evaluation is to exclude malignancy. Fine-needle aspiration cytology (FNAC) represents the main diagnostic tool for the evaluation of thyroid nodules. However, FNAC has a main diagnostic limit, namely cellular atypias of indeterminate significance, which require surgical excision and histological examination to differentiate benign from malignant lesions...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28497108/a-meta-analysis-of-endoscopic-ultrasound-fine-needle-aspiration-compared-to-endoscopic-ultrasound-fine-needle-biopsy-diagnostic-yield-and-the-value-of-onsite-cytopathological-assessment
#18
REVIEW
Muhammad Ali Khan, Ian S Grimm, Bilal Ali, Richard Nollan, Claudio Tombazzi, Mohammad Kashif Ismail, Todd H Baron
Background The diagnostic yield of endoscopic ultrasound (EUS) guided fine-needle aspiration (FNA) is variable, and partly dependent upon rapid onsite evaluation (ROSE) by a cytopathologist. Second generation fine-needle biopsy (FNB) needles are being increasingly used to obtain core histological tissue samples. Aims Studies comparing the diagnostic yield of EUS guided FNA versus FNB have reached conflicting conclusions. We therefore conducted a systematic review and meta-analysis to compare the diagnostic yield of FNA with FNB, and specifically evaluating the diagnostic value of ROSE while comparing the two types of needles...
May 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28488195/differences-in-clinical-features-between-subcategories-of-atypia-follicular-lesion-of-undetermined-significance
#19
Seong Dong Kim, Seung Hoon Han, Woo-Jin Jeong, Hyojin Kim, Soon Hyun Ahn
Within the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), category III (atypia or follicular lesion of undetermined significance (AUS/FLUS)) comprises specimens with heterogeneous features and the need for subcategorization has been reported. We compared the clinical features of two subgroups from within the category of AUS/FLUS to determine precise guidelines for clinicians who explain the results of fine-needle aspiration (FNA) to patients. Retrospective review was performed including data from all patients who underwent FNA with results reported as AUS/FLUS at a single tertiary hospital from January 2010 to August 2014...
May 9, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28474649/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-diagnosing-mediastinal-lymphadenopathy
#20
Tanushree Gahlot, Ujjwal Parakh, Kusum Verma, Bobby Bhalotra, Neeraj Jain
CONTEXT: The diagnosis of mediastinal lymphadenopathy is always a challenge. There always a need of a technique that is highly accurate as well as safe for diagnosis the same. AIMS: The aim of the study is to assess the clinical usefulness and safety profile of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in diagnosing the patients with mediastinal lymphadenopathy. SETTINGS AND DESIGN: This was an observational prospective study...
May 2017: Lung India: Official Organ of Indian Chest Society
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