Mehrnaz Salahi, Sina Parsa, Delaram Nourmohammadi, Zahra Razmkhah, Omid Salimi, Mohammadreza Rahmani, Saeid Zivary, Monireh Askarzadeh, Mohammad Amin Tapak, Ali Vaezi, Hamidreza Sadeghsalehi, Shirin Yaghoobpoor, Mehran Mottahedi, Setareh Garousi, Niloofar Deravi
Migraine headaches are highly prevalent, affecting 15% of the population. However, despite many studies to determine this disease's mechanism and efficient management, its pathophysiology has not been fully elucidated. There are suggested hypotheses about the possible mediating role of mast cells, immunoglobulin E, histamine, and cytokines in this disease. A higher incidence of this disease in allergic and asthma patients, reported by several studies, indicates the possible role of brain mast cells located around the brain vessels in this disease...
2022: Frontiers in Neurology