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https://www.readbyqxmd.com/read/29145319/primary-myelofibrosis-and-pregnancy-outcomes-after-low-molecular-weight-heparin-administration-a-case-report-and-literature-review
#1
Roxana Elena Bohîlţea, Monica Mihaela Cîrstoiu, Crîngu Antoniu Ionescu, Emilia Niculescu-Mizil, Ana Maria Vlădăreanu, Irina Voican, Mihai Dimitriu, Natalia Turcan
RATIONALE: Primary myelofibrosis is encountered with the myeloproliferative diseases and is the least prevalent among women of childbearing age. The prognosis is guided by pancytopenia, leukemic transformation and thrombosis which are the dominant complications. PATIENT CONCERNS: Data regarding protocol management during pregnancy in the context of myelofibrosis are insufficient. Fewer than ten cases have been described until now and half of this cases have resulted in fetal death due to placental infarction during the second and third trimesters...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143222/quantitative-analysis-of-the-level-of-readability-of-online-emergency-radiology-based-patient-education-resources
#2
David R Hansberry, Michael D'Angelo, Michael D White, Arpan V Prabhu, Mougnyan Cox, Nitin Agarwal, Sandeep Deshmukh
PURPOSE: The vast amount of information found on the internet, combined with its accessibility, makes it a widely utilized resource for Americans to find information pertaining to medical information. The field of radiology is no exception. In this paper, we assess the readability level of websites pertaining specifically to emergency radiology. METHODS: Using Google, 23 terms were searched, and the top 10 results were recorded. Each link was evaluated for its readability level using a set of ten reputable readability scales...
November 15, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29141311/-study-on-mosaicism-of-scn1a-gene-mutation-in-parents-of-children-with-dravet-syndrome
#3
A J Liu, X X Yang, X J Xu, Q X Wu, X J Tian, X L Yang, X R Wu, L P Wei, Y H Zhang
Objective: To investigate the clinical phenotypes and the mutant allele proportion of parents with SCN1A gene mutation mosaicism of Dravet syndrome (DS) children, thus to provide guidance for family reproduction and prenatal diagnosis. Method: The clinical data and peripheral blood DNA samples of DS patients with a SCN1A gene mutation proved by Sanger sequencing were collected prospectively from February 2005 to November 2016 in Department of Pediatrics, Peking University First Hospital. The same mutation was searched in parents and other available relatives...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29139276/preventing-stroke-and-assessing-risk-in-women
#4
Tracey Keteepe-Arachi, Sanjay Sharma
Ischaemic stroke is rare in premenopausal women but risk increases with advancing age and doubles in the ten years following the menopause. Up to the age of 75 years men have a 25% higher risk of suffering a stroke compared with women. However, the increased life expectancy of women ultimately results in a higher overall incidence. Twice as many women die from stroke compare with breast cancer. Women with cerebrovascular disease are more likely to present with atypical symptoms than men. Altered mental status (including unresponsiveness, confusion and behavioural change) is the most common nonconventional symptom, and is reported by 23% of women compared with 15% of men...
March 2017: Practitioner
https://www.readbyqxmd.com/read/29132070/sixteen-year-history-of-rituximab-therapy-for-1085-pemphigus-vulgaris-patients-a-systematic-review
#5
REVIEW
Soheil Tavakolpour, HamidReza Mahmoudi, Kamran Balighi, Robabeh Abedini, Maryam Daneshpazhooh
Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising treatment for PV. In this study, a systematic review was conducted to conclude on how and which PV patients could benefit from rituximab infusion. Search in PubMed results in 114 relevant studies, which met the criteria...
November 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29127865/which-information-on-women-s-issues-in-epilepsy-does-a-community-pharmacist-need-to-know-a-delphi-consensus-study
#6
Ramzi Shawahna
OBJECTIVE: The aim of this study was to develop and achieve consensus on a core list of important knowledge items that community pharmacists should know on women's issues in epilepsy. METHODS: This was a consensual study using a modified Delphi technique. Knowledge items were collected from the literature and from nine key contacts who were interviewed on their views on what information community pharmacists should have on women's issues in epilepsy. More knowledge items were suggested by five researchers with interest in women's issues who were contacted to rate and comment on the knowledge items collected...
November 8, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29126794/interventions-for-reducing-fear-of-childbirth-a-systematic-review-and-meta-analysis-of-clinical-trials
#7
Vahideh MoghaddamHosseini, Milad Nazarzadeh, Shayesteh Jahanfar
INTRODUCTION: Fear of childbirth is a problematic mental health issue during pregnancy. But, effective interventions to reduce this problem are not well understood. OBJECTIVES: To examine effective interventions for reducing fear of childbirth. MATERIAL AND METHODS: The Cochrane Central Register of Controlled Trials, PubMed, Embase and PsycINFO were searched since inception till September 2017 without any restriction. Randomised controlled trials and quasi-randomised controlled trials comparing interventions for treatment of fear of childbirth were included...
November 7, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29112778/clinical-application-of-hysteroscopic-hydrotubation-for-unexplained-infertility-in-the-mare
#8
Y Inoue, M Sekiguchi
BACKGROUND: Therapeutic techniques for oviductal obstruction in the mare are limited. Non-surgical and retrograde flushing may be an attractive alternative to current treatment methods for oviductal blockage. OBJECTIVES: To evaluate hysteroscopic selective hydrotubation as a treatment option for presumptive equine oviductal blockage. STUDY DESIGN: Retrospective case series. METHODS: Ten ml of saline was flushed through the oviducts in 28 standing sedated mares, which had reproductive histories of unexplained subfertility, by inserting a catheter into the uterotubal junction under endoscopic guidance...
November 7, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29108905/-maternal-deaths-due-to-infectious-cause-results-from-the-french-confidential-enquiry-into-maternal-deaths-2010-2012
#9
A Rigouzzo, V Tessier, L Zieleskiewicz
Over the period 2010-2012, maternal mortality from infectious causes accounted for 5% of maternal deaths by direct causes and 16% of maternal deaths by indirect causes. Among the 22 deaths caused by infection occurred during this period, 6 deaths were attributed to direct causes from genital tract origin, confirming thus the decrease in direct maternal deaths by infection during the last ten years. On the contrary, indirect maternal deaths by infection, from extragenital origin, doubled during the same period, with 16 deaths in the last triennium, dominated by winter respiratory infections, particularly influenza: the 2009-2010 influenza A (H1N1) virus pandemic was the leading cause of indirect maternal mortality by infection during the studied period...
November 3, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29108161/psychological-impact-of-abortion-due-to-fetal-anomaly-a-review-of-published-research
#10
Nora Sullivan, Eoghan de Faoite
Over the past several decades, prenatal testing for fetal anomalies has become standard across the developed world. Most women who learn of a severe anomaly during pregnancy elect to terminate. The authors reviewed ten studies which examined the psychological sequelae of pregnant women following prenatal diagnoses of severe life limiting conditions. Based on the available data, the authors found evidence that women who abort due to a poor prenatal diagnosis are at higher risk of post-traumatic stress and depression than women who continue with pregnancy...
2017: Issues in Law & Medicine
https://www.readbyqxmd.com/read/29105047/hepatitis-e-virus-seroprevalence-in-pregnant-women-in-pakistan-maternal-and-fetal-outcomes
#11
Najma Javed, Sultana H Ullah, Nazli Hussain, Munir A Sheikh, Ambreen Khan, Farkhanda Ghafoor, Rukhsana Firdous, Waqar Uddin, Arif N Saqib, Ghazal Muhyudin
Hepatitis E virus (HEV) is endemic in Pakistan. Although otherwise asymptomatic, HEV infection becomes fatal in pregnancy, with considerable maternal and fetal morbidity and mortality. We conducted a descriptive study from April to October 2015 in 10 tertiary care hospitals throughout Pakistan to determine maternal and fetal morbidity and mortality in HEV-positive pregnant women with acute jaundice or raised liver function tests. Twenty-one of 135 women were HEV positive and in 3rd trimester except for 1 in 1st trimester...
October 30, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29097224/pharmacy-access-to-ulipristal-acetate-in-major-cities-throughout-the-united-states
#12
Maryssa Shigesato, Jennifer Elia, Mary Tschann, Holly Bullock, Eric Hurwitz, Yan Yan Wu, Jennifer Salcedo
OBJECTIVE: Ulipristal acetate (UPA) is a prescription emergency contraceptive pill (ECP). Despite the potential for UPA to reduce the risk of unintended pregnancies, a recent study in Hawaii demonstrated less than 3% of pharmacies stocked UPA and less than 23% reported the ability to order it. The primary outcome of our study was to assess the availability of UPA in a sample of large cities nationwide. STUDY DESIGN: We conducted a telephone-based secret shopper study of 533 retail pharmacies sampled proportionally from ten large cities in five geographic regions across the US...
October 30, 2017: Contraception
https://www.readbyqxmd.com/read/29091992/transcriptome-wide-analysis-suggests-that-temporal-changes-in-the-relative-contributions-of-hyperplasia-hypertrophy-and-apoptosis-underlie-liver-growth-in-pregnant-mice
#13
Leonie R Price, Karen A Lillycrop, Nicola A Irvine, Mark A Hanson, Graham C Burdge
Maternal liver undergoes structural and metabolic changes during pregnancy to meet the demands of the developing fetus. In rodents, this involves increased liver weight, but the mechanism remains unclear. To address this, we analysed the histology, gene expression and DNA methylation of livers of non-pregnant and pregnant C57/BL6 mice. Gestational liver growth in pregnant mice was accompanied by increased hepatocyte area and lower cell density (days 14,18). Expression of cell proliferation markers was increased on days 14 and 18...
October 30, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29082583/the-risk-of-ischaemic-stroke-in-primary-aps-patients-a-prospective-study
#14
Massimo Radin, Karen Schreiber, Irene Cecchi, Dario Roccatello, Maria José Cuadrado, Savino Sciascia
BACKGROUND: The most common neurological manifestation of APS is ischaemic stroke. Identifying patients with APS at high risk for developing any thrombotic event remains a major challenge. In this study, we aimed to identify predictive factors of ischaemic stroke in a cohort of primary APS (PAPS) patients who presented with new onset symptoms suggestive of acute stroke. METHODS: This prospective multicenter study included 36 consecutive PAPS patients who presented with new onset symptoms suggestive of an acute stroke...
October 30, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29064543/effect-of-valproic-acid-administration-during-pregnancy-on-postnatal-development-of-cerebellar-cortex-and-the-possible-protective-role-of-folic-acid
#15
Saber I Shona, Ayman A Rizk, Abir O El Sadik, Hossam Y Emam, Eid N Ali
BACKGROUND: Valproic acid (VPA), one of the most important antiepileptic drugs (AEDs), is proved to be inevitable for epileptic pregnant women to limit the hazards of convulsions on the fetuses and mothers. Periconceptional folic acid supplementation was investigated to protect against several birth defects. However, its role against VPA cerebellar toxicity was not properly investigated. AIM: The present study was conducted to evaluate the protective effect of folic acid against VPA cerebellar neurotoxicity...
October 24, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29059452/first-trimester-crown-rump-length-and-risk-of-chromosomal-aberrations-a-systematic-review-and-meta-analysis
#16
Lena Sagi-Dain, Amir Peleg, Shlomi Sagi
Importance: Lower than expected first-trimester crown-rump length (CRL) is a common sonographic finding, usually leading to reassessment of gestational age. Objective: The aim of this study was to perform a meta-analysis defining the risk of chromosomal aberrations in pregnancies with decreased first-trimester CRL. Evidence Acquisition: A search was conducted by a research librarian in 5 databases, with no time or language restrictions. Original researches examining the risk of chromosomal aberrations in pregnancies with low CRL were selected...
October 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29053439/factors-influencing-indonesian-women-s-use-of-maternal-health-care-services
#17
Anna Kurniati, Ching-Min Chen, Ferry Efendi, Sarni Maniar Berliana
Employing the 2012 Indonesia Demographic and Health Survey data, we aimed to examine factors influencing married women to use maternity services. Data of married women who had given birth in the last five years before the survey were included in the analysis (n = 14,672). Factors of education, employment, women's age at first marriage, age at first birth, spousal education difference, contraceptive use, place of residence, and woman's attitude toward wife beating were associated with the use of antenatal care, institutional delivery, and postnatal care services...
October 20, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/29052334/partner-smoking-influences-whether-mothers-quit-smoking-during-pregnancy-a-prospective-cohort-study
#18
R M Román-Gálvez, C Amezcua-Prieto, R Olmedo-Requena, A M Lewis-Mikhael Saad, J M Martínez-Galiano, A Bueno-Cavanillas
OBJECTIVE: To analyze the prevalence and intensity of smoking among pregnant women and their partners and factors associated with quitting smoking among pregnant women. DESIGN: A prospective cohort study starting in 2013. SETTING: Andalusia, the south of Spain. SAMPLE: 486 healthy pregnant women followed up on three occasions during pregnancy. METHODS: Estimation of the proportions of women and partners who quit smoking at each trimester...
October 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29046705/super-pregnancy-in-a-balb-c-mouse-superovulated-with-pmsg
#19
Hanieh Vaseghi, Asghar Mogheiseh, Masood Sepehrimanesh, Mojtaba Kafi, Mohammad Hossein Nooranizadeh
This paper reports a case of super pregnancy in a BALB/c mouse pregnant with 30 pups following induction of superovulation using a PMSG-hCG protocol. Superovulation was induced in 10 mice by injecting 5 IU PMSG followed by 5 IU hCG 48 hours later. Immediately after injection of hCG, animals were placed with males at a ratio of 1 to 1 for 24 hours. On day 14 after mating, animals were killed by cervical dislocation and the uterus was examined for pregnancy and the number of fetuses. The mean (±SEM) number of fetuses observed in ten mice was 5...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29045667/survey-of-reproductive-experiences-and-outcomes-of-cancer-survivors-who-stored-reproductive-material-before-treatment
#20
K Hammarberg, M Kirkman, C Stern, R I McLachlan, G Clarke, F Agresta, D Gook, L Rombauts, B Vollenhoven, J R W Fishe
STUDY QUESTION: What are the reproductive experiences and outcomes of people who store reproductive material before cancer treatment? SUMMARY ANSWER: Of respondents who had tried to achieve pregnancy since completing cancer treatment almost all had succeeded, in most cases through natural conception. WHAT IS KNOWN ALREADY: People of reproductive age who are diagnosed with cancer can cryopreserve reproductive material to guard against the adverse effects on fertility of gonadotoxic treatment...
October 17, 2017: Human Reproduction
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