Thaís Caroline Dallabona Dombroski, Jose Eduardo Peixoto-Santos, Karina Maciel, Munira Muhammad Abdel Baqui, Tonicarlo Rodrigues Velasco, Americo Ceiki Sakamoto, João Alberto Assirati, Carlos Gilberto Carlotti, Hélio Rubens Machado, Gleice Kelly de Sousa, Kenji Hanamura, João Pereira Leite, Jaderson Costa da Costa, André Luiz Palmini, Eliseu Paglioli, Luciano Neder, Roberto Spreafico, Tomoaki Shirao, Rita Garbelli, Antonio Roberto Martins
OBJECTIVE: Drebrins are crucial for synaptic function and dendritic spine development, remodeling, and maintenance. In temporal lobe epilepsy (TLE) patients, a significant hippocampal synaptic reorganization occurs, and synaptic reorganization has been associated with hippocampal hyperexcitability. This study aimed to evaluate, in TLE patients, the hippocampal expression of drebrin using immunohistochemistry with DAS2 or M2F6 antibodies that recognize adult (drebrin A) or adult and embryonic (pan-drebrin) isoforms, respectively...
August 2020: Epilepsia