Read by QxMD icon Read


Franciele Cristina Kipper, Andrew Oliveira Silva, André Luis Marc, Gláucia Confortin, Augusto Valadão Junqueira, Eliseu Paglioli Neto, Guido Lenz
Glioblastoma (GBM) is a very aggressive tumor that has not had substantial therapeutic improvement since the introduction of temozolomide (TMZ) in combination with radiotherapy. Combining TMZ with other chemotherapeutic agents is a strategy that could be further explored for GBM. To search for molecular predictors of TMZ resistance, the TCGA (The Cancer Genome Atlas) database was utilized to assess the impact of specific genes on TMZ response. Patients whose tumors expressed low levels of FGFR3 and AKT2 responded poorly to TMZ...
August 29, 2017: Investigational New Drugs
Daniel Rodrigo Marinowic, Fernanda Majolo, Alessandra Deise Sebben, Vinicius Duval da Silva, Tiago Giuliani Lopes, Eliseu Paglioli, André Palmini, Denise Cantarelli Machado, Jaderson Costa da Costa
Focal cortical dysplasia (FCD) is caused by numerous alterations, which can be divided into abnormalities of the cortical architecture and cytological variations; however, the exact etiology of FCD remains unknown. The generation of induced pluripotent stem cells (iPSCs) from the cells of patients with neurological diseases, and their subsequent tissue‑specific differentiation, serves as an invaluable source for testing and studying the initial development and subsequent progression of diseases associated with the central nervous system...
April 2017: Molecular Medicine Reports
Albert Vincent Berthier Brasil, Alisson R Teles, Marcelo Ricardo Roxo, Marcelo Neutzling Schuster, Eduardo Ballverdu Zauk, Gabriel da Costa Barcellos, Pablo Ramon Fruett da Costa, Nelson Pires Ferreira, Jorge Luiz Kraemer, Marcelo Paglioli Ferreira, Pedro Luis Gobbato, Paulo Valdeci Worm
Objective: To analyze the cumulative effect of risk factors associated with early major complications in postoperative spine surgery. Methods: Retrospective analysis of 583 surgically-treated patients. Early "major" complications were defined as those that may lead to permanent detrimental effects or require further significant intervention. A balanced risk score was built using multiple logistic regression. Results: Ninety-two early major complications occurred in 76 patients (13%)...
October 2016: Arquivos de Neuro-psiquiatria
Eliseu Paglioli, William Alves Martins, Ney Azambuja, Mirna Portuguez, Thomas More Frigeri, Larissa Pinos, Ricardo Saute, Cora Salles, João Rubião Hoefel, Ricardo Bernardi Soder, Jaderson Costa da Costa, Marta Hemb, Tom Theys, André Palmini
OBJECTIVE: To evaluate a novel approach to control epileptic drop attacks through a selective posterior callosotomy, sparing all prefrontal interconnectivity. METHODS: Thirty-six patients with refractory drop attacks had selective posterior callosotomy and prospective follow-up for >4 years. Falls, episodes of aggressive behavior, and IQ were quantified. Autonomy in activities of daily living, axial tonus, and speech generated a functional score ranging from 0 to 13...
November 8, 2016: Neurology
Gislaine Baroni, Vitoria Piccinini, William Alves Martins, Luciano de Paola, Eliseu Paglioli, Regina Margis, André Palmini
PURPOSE: Epileptic seizures (ES) have many mimickers, perhaps the most relevant being psychogenic nonepileptic seizures (PNES). The picture is even more challenging when PNES are associated with ES in a given patient. The aim of this research paper was to delineate the demographic, epileptological and psychiatric profile of that specific population. METHODS: A systematic review was carried out from 2000 to 2015 for articles in English, French, Italian, Spanish and Portuguese in PUBMED and EMBASE...
April 2016: Seizure: the Journal of the British Epilepsy Association
Eliseu Paglioli, William Alves Martins, Walter De la Cruz, Victor Andrade, Vinicius Duval da Silva, Rafael Menezes Nunes, André Palmini
Epilepsia partialis continua is often refractory to antiepileptic medication and its causal relation to peripheral sensory stimuli has only rarely been suggested. We report a man who received surgery for temporal lobe epilepsy 10 years ago, who presented "de novo" epilepsia partialis continua following mild traumatic injury of the left hand. Continuous myoclonus of the left upper limb started the day after injury and persisted unabated for several weeks. Non-invasive evaluation was inconclusive. Acute electrocorticography during surgery under local anaesthesia revealed continuous, rhythmic spiking over the right sensorimotor cortex...
March 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
Wim Naets, Johannes Van Loon, Eliseu Paglioli, W Van Paesschen, André Palmini, Tom Theys
Precise anatomical knowledge of the structure of the corpus callosum is important in split-brain research and during neurosurgical procedures sectioning the callosum. According to the classic literature, commissural fibers connecting the motor cortex are situated in the anterior part of the corpus callosum. On the other hand, more recent imaging studies using diffusion tensor imaging indicate a more posterior topography of callosal fibers connecting motor areas. Topographical knowledge is especially critical when performing disconnective callosotomies in epilepsy patients who experience sudden loss of leg motor control, so-called epileptic drop attacks...
January 2017: Brain Structure & Function
William Alves Martins, Eliseu Paglioli, Marta Hemb, Andre Palmini
Subcortical epilepsy has been a controversial issue, partially settled by evidence showing seizure generation in hypothalamic hamartomas and also by reports of seizures caused by cerebellar lesions. We report 4-year-old girl with right hemifacial seizures and autonomic phenomena, in whom MRI showed an irregular mass in the right cerebellar peduncle. Despite several unremarkable video-EEG recordings, seizure origin in the lesion was hypothesized. Complete resection was feasible, histopathology showed a ganglioglioma, and she has been seizure free for 3 years...
August 2016: Cerebellum
Thomas Frigeri, Marta Hemb, Eliseu Paglioli, João Rubião Hoefel, Vinicius Silva, Harry Vinters, Andre Palmini
Rasmussen's encephalitis (RE) is an inflammatory, probably autoimmune disorder manifested by refractory seizures and progressive deterioration of one cerebral hemisphere [1]. Here, we describe the unfortunate history of a girl with a progressive disorder which, upon clinical, neuroimaging, and histopathological evaluation, proved to be bilateral RE associated with type II focal cortical dysplasia. Whether the second pathology is relevant for the extent of the disease is discussed. We demonstrated histopathological evidence of RE and type II FCD in the left hemisphere, which led to EPC on the right hemibody at presentation...
2013: Epilepsy & Behavior Case Reports
Thomas Frigeri, Eliseu Paglioli, Evandro de Oliveira, Albert L Rhoton
OBJECT: The central lobe consists of the pre- and postcentral gyri on the lateral surface and the paracentral lobule on the medial surface and corresponds to the sensorimotor cortex. The objective of the present study was to define the neural features, craniometric relationships, arterial supply, and venous drainage of the central lobe. METHODS: Cadaveric hemispheres dissected using microsurgical techniques provided the material for this study. RESULTS: The coronal suture is closer to the precentral gyrus and central sulcus at its lower rather than at its upper end, but they are closest at a point near where the superior temporal line crosses the coronal suture...
March 2015: Journal of Neurosurgery
Thomas Frigeri, Albert Rhoton, Eliseu Paglioli, Ney Azambuja
OBJECTIVE: To establish preoperatively the localization of the cortical projection of the inferior choroidal point (ICP) and use it as a reliable landmark when approaching the temporal horn through a middle temporal gyrus access. To review relevant anatomical features regarding selective amigdalohippocampectomy (AH) for treatment of mesial temporal lobe epilepsy (MTLE). METHOD: The cortical projection of the inferior choroidal point was used in more than 300 surgeries by one authors as a reliable landmark to reach the temporal horn...
October 2014: Arquivos de Neuro-psiquiatria
Marta Hemb, Eliseu Paglioli, François Dubeau, Frederick Andermann, André Olivier, Jaderson C da Costa, William A Martins, Magda L Nunes, André Palmini
BACKGROUND: Epilepsia partialis continua (EPC) is a life-threatening condition often caused by focal cortical dysplasia (FCD). Resection of the motor cortex is contemplated in the hope that the trade-off between a severe motor deficit and complete seizure control justifies the procedure. METHODS: Report of 3 patients with EPC due to histologically confirmed FCD, who underwent resection of the motor cortex under acute electrocorticography. RESULTS: All had re-emergence of medically intractable EPC in the other side of the body after rolandic resection...
October 14, 2014: Neurology
Lara E Jehi, Andre Palmini, Usha Aryal, Roland Coras, Eliseu Paglioli
Cavernous cerebral malformations (CCMs) are a well-defined epilepsy-associated pathology. They represent lesions/conglomerates of abnormally configured vessels leading to seizures either as a result of physiological changes affecting the cerebral cortex immediately surrounding the CCM (an epileptogenic mechanism that is relevant for both temporal and extratemporal lesions), or as a result of promoting epileptogenicity in remote but anatomo-functionally connected brain regions (a mechanism that is particularly relevant for temporal lobe lesions)...
July 2014: Acta Neuropathologica
André Palmini, Eliseu Paglioli, Vinicius Duval Silva
Developmental tumors often lead to refractory partial seizures and constitute a well-defined, surgically remediable epilepsy syndrome. Dysplastic features are often associated with these tumors, and their significance carries both practical and conceptual relevance. If associated focal cortical dysplasia (FCD) relates to the extent of the epileptogenic tissue, then presurgical evaluation and surgical strategies should target both the tumor and the surrounding dyslaminated cortex. Furthermore, the association has been included in the recently revised classification of FCD and the epileptogenicity of this associated dysplastic tissue is crucial to validate such revision...
December 2013: Epilepsia
Tharick Pascoal, Eliseu Paglioli, André Palmini, Rafael Menezes, Martin Staudt
Hemispherectomy often leads to a loss of contralateral hand function. In some children with congenital hemiparesis, however, paretic hand function remains unchanged. An immediate improvement of hand function has never been reported. A 17-year-old boy with congenital hemiparesis and therapy-refractory seizures due to a large infarction in the territory of the middle cerebral artery underwent epilepsy surgery. Intraoperatively, electrical cortical stimulation of the affected hemisphere demonstrated preserved motor projections from the sensorimotor cortex to the (contralateral) paretic hand...
August 2013: Epilepsia
Lucas P Schilling, Renata R Kieling, Tharick A Pascoal, Hyoung-Ihl Kim, Min Cheol Lee, Yun Hee Kim, Eliseu Paglioli, Pedro R Neto, Jaderson C Costa, Andre Palmini
PURPOSE: Interest in the association of epilepsy and pseudobulbar palsy was rekindled since the identification through magnetic resonance imaging (MRI) of bilateral perisylvian polymicrogyria (PMG). Seizures are often intractable, but resective epilepsy surgery has not been recommended. However, a similar clinical picture can be encountered in patients with bilateral perisylvian destructive lesions, which fit the description of ulegyria (ULG). We report a series of patients with epilepsy and pseudobulbar palsy due to bilateral perisylvian ULG (BP-ULG), show that hippocampal sclerosis (HS) is often associated and highlight the fact that in this entity, unlike in malformative bilateral perisylvian PMG, seizures may be surgically treated...
August 2013: Epilepsia
Imad Najm, Lara Jehi, Andre Palmini, Jorge Gonzalez-Martinez, Eliseu Paglioli, William Bingaman
Epilepsy surgery is an accepted treatment option in patients with medically refractory focal epilepsy. Despite various advances in recording and localization noninvasive and invasive techniques (including electroencephalography (EEG), magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetoencephalography (MEG), subdural grids, depth electrodes, and so on), the seizure outcome following surgical resection remains suboptimal in a significant number of patients...
May 2013: Epilepsia
Marta Hemb, Andre Palmini, Eliseu Paglioli, Eduardo Beck Paglioli, Jaderson Costa da Costa, Ney Azambuja, Mirna Portuguez, Verena Viuniski, Linda Booij, Magda Lahorgue Nunes
OBJECTIVES: To evaluate the very long-term clinical outcome of surgery for mesial temporal lobe epilepsy and unilateral hippocampal sclerosis (MTLE/HS) without atypical features. The impact of surgical technique and postoperative reduction of medication on this outcome was investigated. DESIGN: Prospective longitudinal cohort follow-up study for up to18 years. SETTING: Epilepsy surgery centre in a university hospital. PATIENTS: 108 patients who underwent unilateral MTLE/HS...
July 2013: Journal of Neurology, Neurosurgery, and Psychiatry
Paulo Valdeci Worm, Nelson Pires Ferreira, Marcelo Paglioli Ferreira, Jorge Luiz Kraemer, Rene Lenhardt, Ronnie Peterson Marcondes Alves, Ricardo Castilho Wunderlich, Marcus Vinicius Martins Collares
Current methods to evaluate the biologic development of bone grafts in human beings do not quantify results accurately. Cranial burr holes are standardized critical bone defects, and the differences between bone powder and bone grafts have been determined in numerous experimental studies. This study evaluated quantitative computed tomography (QCT) as a method to objectively measure cranial bone density after cranial reconstruction with autografts. In each of 8 patients, 2 of 4 surgical burr holes were reconstructed with autogenous wet bone powder collected during skull trephination, and the other 2 holes, with a circular cortical bone fragment removed from the inner table of the cranial bone flap...
May 2012: Journal of Craniofacial Surgery
Paulo Valdeci Worm, Marcelo Paglioli Ferreira, Nelson Pires Ferreira, Fernanda Cechetti
No abstract text is available yet for this article.
June 2009: Arquivos de Neuro-psiquiatria
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"