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Hypothyroidism 2016

Kevin Phan, Joshua Xu, Rajesh Reddy, Piyush Kalakoti, Anil Nanda, Jacob Fairhall
BACKGROUND: The pituitary adenoma causing acromegaly is typically resected through a transsphenoidal approach and visualised with an operating microscope or endoscope. We undertook a systematic review and meta-analysis examining the clinical efficacy of endoscopic and microsurgical approaches. METHODS: Relevant studies using either endoscopic or microscopic transphenoid approaches for growth-hormone pituitary adenomas were identified up to Feb 2016. Data were extracted and analyzed according to predefined clinical endpoints...
October 15, 2016: World Neurosurgery
James V Hennessey
No abstract text is available yet for this article.
October 17, 2016: Endocrine Practice
Alfredo Campennì, Salvatore Giovinazzo, Salvatore Antonio Pignata, Francesca Di Mauro, Domenico Santoro, Lorenzo Curtò, Francesco Trimarchi, Rosaria Maddalena Ruggeri, Sergio Baldari
Parathyroid carcinoma is a rare malignancy, which usually occurs as a sporadic disease, and less frequently in the setting of genetic syndromes. Despite the association of parathyroid and thyroid disorders being quite common, the coexistence of parathyroid carcinoma and thyroid disease is rare. We reviewed the pertinent literature. The terms "parathyroid carcinoma" and "thyroid disease, hyperthyroidism, thyrotoxicosis, hypothyroidism, thyroid nodule(s), Graves' disease, autonomously functioning thyroid nodules" were used both separately and in reciprocal conjunction to search MEDLINE for articles published from January 2007 to March 2016...
October 15, 2016: Endocrine
Muthukrishnan Jayaraman, Anil Kumar Pawah, C S Narayanan
INTRODUCTION: Early and durable achievement of euthyroid or hypothyroid status with low likelihood of relapse is the key to effective treatment of Graves' disease (GD). Although antithyroid drugs (ATDs) are commonly used first-line agents, likelihood of remission remains highest with radioactive iodine (RAI) therapy and surgery. Data regarding efficacy and economical superiority of RAI therapy over ATDs are lacking from India. This study was designed to study the response to long-term (>12 months) use of ATDs in GD with respect to attainment of remission and to compare the cost of treatment with ATDs versus RAI therapy beyond 12 months...
September 2016: Indian Journal of Endocrinology and Metabolism
Connie Y Chang, Daniel I Rosenthal, Deborah M Mitchell, Atsuhiko Handa, Susan V Kattapuram, Ambrose J Huang
Metabolic bone diseases are a diverse group of diseases that result in abnormalities of (a) bone mass, (b) structure mineral homeostasis, (c) bone turnover, or (d) growth. Osteoporosis, the most common metabolic bone disease, results in generalized loss of bone mass and deterioration in the bone microarchitecture. Impaired chondrocyte development and failure to mineralize growth plate cartilage in rickets lead to widened growth plates and frayed metaphyses at sites of greatest growth. Osteomalacia is the result of impaired mineralization of newly formed osteoid, which leads to characteristic Looser zones...
October 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Zari Tahannejad Asad, Majid Ghazanfari, Seyyed Nima Naleini, Azam Sabagh, Wesam Kooti
INTRODUCTION: Regarding the functioning of the endocrine system, and especially in the thyroid of patients with thalassemia, multiple studies in different parts of the world have reported conflicting results. The aim of this study was to assess the levels of thyroid hormones and TSH in beta-thalassemic patients in the city of Ahwaz. METHODS: In this matched case-control study, 105 patients in the case group and 105 subjects as controls were randomly selected from clients referred to the Abuzar hospital in 2015-2016...
July 2016: Electronic Physician
I Miller, J Renaut, S Cambier, A J Murk, A C Gutleb, T Serchi
Male Wistar rats with different thyroid status (eu-, hypothyroid) were exposed to 0, 3 or 30 mg/kg body weight of the flame retardant HBCD for 7 days and obtained data compared with a previous study in females, "Hexabromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats" (Miller et al., 2016) [1]. Specifically, proteomic investigation of liver protein patterns obtained by 2D-DIGE was performed and differences between animals groups recorded, based on the factors exposure, thyroid status and gender...
September 2016: Data in Brief
B Biondi, L Bartalena, L Chiovato, A Lenzi, S Mariotti, F Pacini, A Pontecorvi, P Vitti, F Trimarchi
Levothyroxine (L-T4) is recommended as lifelong replacement therapy for hypothyroidism. Recent clinical and experimental data support the addition of levotriiodothyronine (L-T3) treatment in some selected hypothyroid patients when their symptoms persist and their quality of life remains impaired despite adequate L-T4 monotherapy. An increase in L-T3 prescriptions has been recently observed in Italy due to availability of different L-T3 formulations, making it possible to clinicians to prescribe L-T3 alone or in combination with L-T4...
July 29, 2016: Journal of Endocrinological Investigation
Fulsen Bozkus, Nursel Dikmen, Gülay Güngör, Anıl Samur
AIM: Obstructive sleep apnea syndrome (OSAS) is a common disorder and in subjects with OSAS the prevalence of hypothyroidism is approximately 1.2-11 %. The episodes of hypoxia/reoxygenation associated with the respiratory disturbances observed in subjects with OSAS increases the risk of cardiovascular diseases. Hypothyroidism; primary or subclinical, has several effects on cardiovascular system. In our study, we investigated carotid artery intima-media thickness (IMT) which is an early sign of atherosclerosis, in OSAS subjects with hypothyroidism...
July 20, 2016: Sleep & Breathing, Schlaf & Atmung
Hoffmann Anika, Hermann L MüLLER
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) presents a disease with a wide spectrum spanning from benign steatosis to steatohepatitis with fibrosis and scarring that can lead to cirrhosis. With increasing prevalence, NAFLD is developing into the leading indication for liver transplantation worldwide. Disturbances in endocrine, hypothalamic-pituitary axes have been associated with NALFD, including GH deficiency, hypothyroidism, hypercortisolaemia, and hypogonadism. EVIDENCE OF ACQUISITION AND SYNTHESIS: In this review, we examine the published data (search: PUBMED, 1990-2016) suggesting a link between endocrine abnormalities of hypothalmic-pituitary axes and NAFLD and summarise the clinical data on risk factors for NAFLD in specific diseases involving hypothalmic-pituitary axes...
July 13, 2016: Minerva Endocrinologica
Y Guo, J Zynat, Z Xu, X Wang, R Osiman, H Zhao, A Tuhuti, M Abdunaimu, H Wang, X Jin, S Xing
BACKGROUND/OBJECTIVES: Iodine nutritional status and its influence on thyroid function have been thoroughly investigated in many places in China, but little is known about Xinjiang province, where multiple minorities are living in a special geographical location and have different lifestyles compared with people from other parts of China. The aim of this study was to evaluate iodine status and thyroid disorders in two major ethnic groups living in the Xinjiang region of China. SUBJECTS/METHODS: A total of 2253 residents over the age of 18 years who had lived in Xinjiang for more than 3 years were enrolled...
May 18, 2016: European Journal of Clinical Nutrition
Dan Justo, Natalia Schwartz, Eliyahu Dvorkin, Irina Gringauz, Asnat Groutz
AIM: To assess the incidence and associated risk factors of asymptomatic urinary retention in elderly women upon admission to the Internal Medicine department. METHODS: Two hundred and two consecutive elderly women (mean age 84.4 ± 5.7 years) who were admitted to four Internal Medicine departments at a tertiary medical center were prospectively enrolled. All patients underwent post-void residual urine (PVR) measurements on the morning following the admission day...
May 13, 2016: Neurourology and Urodynamics
Mattia Gentile, Delia De Mattia, Angela Pansini, Federico Schettini, Antonia Lucia Buonadonna, Manuela Capozza, Romina Ficarella, Nicola Laforgia
Chromosome 14q11-q22 deletion syndrome (OMIM 613457) is a rare genomic disorder whose associated phenotype is heterogeneous, depending on the size, and, mostly, on the deleted region. We report the clinical and molecular characterization of a female newborn, whose phenotype was characterized by poor growth, dysmorphic facial features, subclinical hypothyroidism, and mild reduction of CD3CD8 Lymphocytes with increased CD4/CD8 ratio. By array-CGH, we identified a 4.08 de novo interstitial deletion of the 14q13...
July 2016: American Journal of Medical Genetics. Part A
Paul Dimitri, Elisa De Franco, Abdelhadi M Habeb, Fatih Gurbuz, Khairya Moussa, Doris Taha, Jerry K H Wales, Jacob Hogue, Anne Slavotinek, Ambika Shetty, Meena Balasubramanian
Neonatal diabetes and hypothyroidism (NDH) syndrome was first described in 2003 in a consanguineous Saudi Arabian family where two out of four siblings were reported to have presented with proportionate IUGR, neonatal non-autoimmune diabetes mellitus, severe congenital hypothyroidism, cholestasis, congenital glaucoma, and polycystic kidneys. Liver disease progressed to hepatic fibrosis. The renal disease was characterized by enlarged kidneys and multiple small cysts with deficient cortico-medullary junction differentiation and normal kidney function...
July 2016: American Journal of Medical Genetics. Part A
Noelle Whyte, Christopher Sullivan
When patients who are thin present with knee pain, it can be easy to overlook the possibility of slipped capital femoral epiphysis (SCFE). Although 80% of patients with a "slip" are obese, thin children are not immune to this problem. Endocrinopathies, especially hypothyroidism, can be associated with SCFE. This article describes guidelines for evaluating patients for a slip and highlights some important considerations for the atypical SCFE. Patients with open growth plates with thigh or knee pain should routinely have a hip examination as part of the evaluation...
April 2016: Pediatric Annals
Francesca Mattioli, Amelie Piton, Bénédicte Gérard, Andrea Superti-Furga, Jean-Louis Mandel, Sheila Unger
The cardinal features of Primrose syndrome (MIM 259050) are dysmorphic facial features, macrocephaly, and intellectual disability, as well as large body size, height and weight, and calcified pinnae. A variety of neurological signs and symptoms have been reported including hearing loss, autism, behavioral abormalities, hypotonia, cerebral calcifications, and hypoplasia of the corpus callosum. Recently, heterozygous de novo missense mutations in ZBTB20, coding for a zing finger protein, have been identified in Primrose syndrome patients...
June 2016: American Journal of Medical Genetics. Part A
P Anur, D N Friedman, C Sklar, K Oeffinger, M Castiel, J Kearney, B Singh, S E Prockop, N A Kernan, A Scaradavou, R Kobos, K Curran, J Ruggiero, N Zakak, R J O'Reilly, F Boulad
Hematopoietic stem cell transplantation (HSCT) is curative for hematological manifestations of Fanconi anemia (FA). We performed a retrospective analysis of 22 patients with FA and aplastic anemia, myelodysplastic syndrome or acute myelogenous leukemia who underwent a HSCT at Memorial Sloan Kettering Cancer Center and survived at least 1 year post HSCT. Patients underwent either a TBI- (N=18) or busulfan- (N=4) based cytoreduction followed by T-cell-depleted transplants from alternative donors. Twenty patients were alive at time of the study with a 5- and 10-year overall survival of 100 and 84% and no evidence of chronic GvHD...
July 2016: Bone Marrow Transplantation
Dorte Rytter, Stine L Andersen, Bodil H Bech, Thorhallur I Halldorsson, Tine B Henriksen, Peter Laurberg, Sjurdur F Olsen
BACKGROUND: Experimental evidence exists indicating that maternal thyroid hormones during pregnancy may affect the metabolic set point and cardio-vascular function in the offspring. The objective of this study was to investigate the association between maternal thyroid function in week 30 of gestation and offspring adiposity and blood pressure at 20 y. METHODS: The study was based on the follow up of a Danish birth cohort from 1988 to 1989 (n = 965). A blood sample was drawn from the pregnant women in week 30 of gestation (N = 877)...
July 2016: Pediatric Research
Jorge Román Corona-Rivera, Eugenio Zapata-Aldana, Lucina Bobadilla-Morales, Alfredo Corona-Rivera, Christian Peña-Padilla, Elizabeth Solis-Hernández, Celina Guzmán, Erick Richmond, Christian Zahl, Martin Zenker, Maja Sukalo
Johanson-Blizzard syndrome (JBS) is considered as an infrequent, but clinically easily recognizable autosomal recessive entity by the pathognomonic combination of congenital exocrine pancreatic insufficiency and hypoplastic alae nasi, in addition to other distinctive findings such as scalp defects, hypothyroidism, and rectourogenital malformations. There are few reports of patients with JBS in association with facial clefting, referring all to types 2 to 6 of Tessier's classification that can be characterized properly as oblique facial clefts (OFCs)...
June 2016: American Journal of Medical Genetics. Part A
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