keyword
MENU ▼
Read by QxMD icon Read
search

Hypothyroidism 2016

keyword
https://www.readbyqxmd.com/read/28882978/predictive-factors-of-nivolumab-induced-hypothyroidism-in-patients-with-non-small-cell-lung-cancer
#1
Toshiya Maekura, Maiko Naito, Masahiro Tahara, Naoya Ikegami, Yohei Kimura, Shoko Sonobe, Takehiko Kobayashi, Taisuke Tsuji, Shojiro Minomo, Akihiro Tamiya, Shinji Atagi
BACKGROUND/AIM: Although immune checkpoint inhibitors play an important role in the therapy of lung cancer, they are associated with various immune-related adverse events and predictive factors of them are unclear. In this study, we investigated predictive factors of nivolumab-induced hypothyroidism which is one of the adverse events in patients with lung cancer. PATIENTS AND METHODS: Patients with non-small-cell lung cancer who were administered nivolumab at our hospital between December 2015 and May 2016 were retrospectively enrolled...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28873125/neurological-complications-associated-with-anti-programmed-death-1-pd-1-antibodies
#2
Justin C Kao, Bing Liao, Svetomir N Markovic, Christopher J Klein, Elie Naddaf, Nathan P Staff, Teerin Liewluck, Julie E Hammack, Paola Sandroni, Heidi Finnes, Michelle L Mauermann
Importance: Neurological complications are an increasingly recognized consequence of the use of anti-programmed death 1 (PD-1) antibodies in the treatment of solid-organ tumors, with an estimated frequency of 4.2%. To date, the clinical spectrum and optimum treatment approach are not established. Objective: To investigate the frequency, clinical spectrum, and optimum treatment approach to neurological complications associated with anti-PD-1 therapy. Design, Setting, and Participants: This single-center, retrospective cohort study was conducted from either September or December 2014 (the approval dates of the study drugs by the US Food and Drug Administration) to May 19, 2016...
September 5, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28868261/nonalcoholic-fatty-liver-disease-is-not-associated-with-thyroid-hormone-levels-and-hypothyroidism-a-systematic-review-and-meta-analysis
#3
Veeravich Jaruvongvanich, Anawin Sanguankeo, Sikarin Upala
BACKGROUND: Whether hypothyroidism is related to nonalcoholic fatty liver disease (NAFLD) is unclear. Thyroid dysfunction is closely related with components of metabolic syndrome. Given the hepatic manifestation of metabolic syndrome, several studies have investigated the association between NAFLD and thyroid dysfunction and have demonstrated inconsistent results. Thus, we conducted a systematic review and meta-analysis to better characterize the association between NAFLD and thyroid dysfunction...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28837405/safety-and-antitumor-activity-of-pembrolizumab-in-patients-with-programmed-death-ligand-1-positive-nasopharyngeal-carcinoma-results-of-the-keynote-028-study
#4
Chiun Hsu, Se-Hoon Lee, Samuel Ejadi, Caroline Even, Roger B Cohen, Christophe Le Tourneau, Janice M Mehnert, Alain Algazi, Emilie M J van Brummelen, Sanatan Saraf, Pradeep Thanigaimani, Jonathan D Cheng, Aaron R Hansen
Purpose To establish the safety profile and antitumor activity of the anti-programmed death 1 receptor monoclonal antibody, pembrolizumab, in patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) that expressed programmed death-ligand 1 (PD-L1). Patients and Methods KEYNOTE-028 (NCT02054806) is a nonrandomized, multicohort, phase Ib trial of pembrolizumab in patients with PD-L1-positive advanced solid tumors. Key eligibility criteria for the NPC cohort included unresectable or metastatic disease, failure on prior standard therapy, and PD-L1 expression in 1% or more of tumor cells or tumor-infiltrating lymphocytes...
August 24, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28829155/efficacy-and-safety-of-ashwagandha-root-extract-in-subclinical-hypothyroid-patients-a-double-blind-randomized-placebo-controlled-trial
#5
Ashok Kumar Sharma, Indraneel Basu, Siddarth Singh
BACKGROUND: Subclinical hypothyroidism, a thyroid disorder without obvious symptoms of thyroid deficiency, occurs in 3%-8% of the global population. Ashwagandha [Withania somnifera (L.) Dunal], a traditional medicine in Ayurveda, is often prescribed for thyroid dysfunctions. OBJECTIVE: This pilot study was designed to evaluate the efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients. DESIGN, SETTING, AND PARTICIPANTS: A prospective, randomized, double-blind, single-center placebo-controlled study was performed at Sudbhawana Hospital, Varanasi, India between May 2016 and September 2016...
August 22, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28821377/ischemic-stroke-and-impact-of-thyroid-profile-at-presentation-a-systematic-review-and-meta-analysis-of-observational-studies
#6
Rashmi Dhital, Dilli Ram Poudel, Niranjan Tachamo, Bishal Gyawali, Sijan Basnet, Pragya Shrestha, Paras Karmacharya
BACKGROUND: Stroke is the fifth leading cause of mortality in the United States and a leading cause of disability. A complex relationship between thyroid hormone levels and severity of, and outcome after, stroke has been described. AIM: Our objective is to identify the association between baseline thyroid function profile and outcome after acute ischemic stroke. METHODS: Studies looking at the association between thyroid function and functional stroke outcomes were identified from available electronic databases from inception to December 16, 2016...
August 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28817241/association-between-vitamin-d-deficiency-and-heart-failure-risk-in-the-elderly
#7
Catarina Magalhães Porto, Vanessa De Lima Silva, João Soares Brito da Luz, Brivaldo Markman Filho, Vera Magalhães da Silveira
AIMS: The aim of this study was to evaluate the association between vitamin D deficiency and risk of heart failure in elderly patients of cardiology outpatient clinics. METHODS AND RESULTS: A cross-sectional study with an analytical approach was employed. Clinical data were collected from the elderly from August 2015 to February 2016. The dependent variable was the risk of heart failure; the independent variable was vitamin D deficiency; and intervening factors were age, gender, education, ethnicity, hypertension, diabetes mellitus, hypothyroidism, renal failure, dementia, stroke, dyslipidaemia, depression, smoking, alcoholism, obesity, andropause, and cardiac arrhythmia...
August 17, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28782887/prevalence-of-treated-hypothyroidism-in-the-community-analysis-from-general-practices-in-north-east-england-with-implications-for-the-united-kingdom
#8
Lorna Ingoe, Norah Phipps, Gary Armstrong, Arvind Rajagopal, Farzan Kamali, Salman Razvi
OBJECTIVE: Hypothyroidism is more frequently diagnosed in women and older individuals. It has been suggested that the prevalence of hypothyroidism and the number of prescriptions for thyroid hormones are increasing. However, despite hypothyroidism being a common medical condition, contemporary data on prevalence, particularly across the various age groups, is limited. DESIGN: Information regarding number of individuals diagnosed with treated hypothyroidism (defined as patients prescribed levothyroxine) across ten General Practices (total population of 66 843) in the North-East of England in 2016 was obtained in an anonymized manner...
August 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28781778/glucose-metabolism-before-and-after-radioiodine-therapy-of-a-patient-with-graves-disease-assessment-by-continuous-glucose-monitoring
#9
Yun Hu, Gu Gao, Reng-Na Yan, Feng-Fei Li, Xiao-Fei Su, Jian-Hua Ma
Hyperthyroidism causes impaired glucose tolerance, insulin resistance (IR) and insulin secretion. However, the glucose variability affected by thyroid dysfunction remains unclear. Glucose variability was assessed by continuous glucose monitoring (CGM) in a non-diabetic patient with Graves' disease (GD), to the best of our knowledge, for the first time. A 28-year-old man with GD, who had been taking methimazole for 4 years, was treated with radioiodine on August 17th 2016. Although the patient exhibited normal glycated hemoglobin (HbA1c; 5...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28761733/prevalence-of-hypothyroidism-among-patients-with-breast-cancer-treated-with-radiation-to-the-supraclavicular-field-a-single-centre-survey
#10
Yuichiro Kikawa, Yasuhiro Kosaka, Kazuki Hashimoto, Eri Hohokabe, Sayaka Takebe, Ryo Narukami, Takayuki Hattori, Kazuhiro Ueki, Kengo Ogura, Toshiyuki Imagumbai, Hironori Kato, Masaki Kokubo
PURPOSE: We investigated the prevalence of hypothyroidism (HT) in patients with breast cancer who received radiation therapy to the supraclavicular (SC) field to evaluate the effect of radiation on thyroid. METHODS: Between April 2007 and May 2016, consecutive patients with invasive breast cancer who received SC radiation were recruited. Thyroid-stimulating hormone (TSH) and free thyroxine (fT4) were measured between April and August 2016. On the basis of the radiation-planning CT images, thyroid volume was calculated and dose-volume parameters were estimated...
2017: ESMO Open
https://www.readbyqxmd.com/read/28729151/standard-dose-pembrolizumab-in-combination-with-reduced-dose-ipilimumab-for-patients-with-advanced-melanoma-keynote-029-an-open-label-phase-1b-trial
#11
Georgina V Long, Victoria Atkinson, Jonathan S Cebon, Michael B Jameson, Bernie M Fitzharris, Catriona M McNeil, Andrew G Hill, Antoni Ribas, Michael B Atkins, John A Thompson, Wen-Jen Hwu, F Stephen Hodi, Alexander M Menzies, Alexander D Guminski, Richard Kefford, Benjamin Y Kong, Babak Tamjid, Archana Srivastava, Anna J Lomax, Mohammed Islam, Xinxin Shu, Scot Ebbinghaus, Nageatte Ibrahim, Matteo S Carlino
BACKGROUND: Reduced-dose nivolumab in combination with standard-dose ipilimumab improves objective response and progression-free survival compared with standard-dose ipilimumab alone, but increases toxicity. We assessed the safety and anti-tumour activity of standard-dose pembrolizumab in combination with reduced-dose ipilimumab. METHODS: In this open-label, phase 1b trial, we recruited patients from 12 medical centres in Australia, New Zealand, and the USA. Eligible patients were aged at least 18 years, had advanced melanoma, had an Eastern Coooperative Oncology Group performance status of 0 or 1, had measurable disease according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1...
September 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28695565/dental-patch-testing-in-patients-with-undifferentiated-oral-lichen-planus
#12
Shevya M Tiwari, Kurt Gebauer, Agnieszka M Frydrych, Sally Burrows
BACKGROUND/OBJECTIVES: Distinguishing between oral lichen planus (LP) and lichenoid reactions to dental restorations can be impossible on clinical and histopathological grounds. Epicutaneous patch testing is an investigation that may guide patients and physicians in making timely and costly decisions to replace or cover existing dental restorations. This study aimed to assess the role of epicutaneous patch testing with a battery of dental allergens in patients with undifferentiated oral LP...
July 11, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28689519/insulin-resistance-and-glucose-levels-in-subjects-with-subclinical-hypothyroidism
#13
Sikandar Hayat Khan, Nadeem Fazal, Aamir Ijaz, Syed Mohsin Manzoor, Naveed Asif, Tariq Rafi, Muhammad Yasir, Najmusaquib Khan Niazi
OBJECTIVE: To compare insulin resistance and glycemic indicators among subjects with euthyroidism and subclinical hypothyroidism. STUDY DESIGN: Comparative cross-sectional study. PLACE AND DURATION OF STUDY: Department of Pathology and Medicine, PNS Hafeez, Islamabad, in collaboration with the Department of Chemical Pathology and Endocrinology at the Armed Forces Institute of Pathology (AFIP), Rawalpindi, from December 2015 to September 2016...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28683860/latent-hypothyroidism-in-adults
#14
Jeannine Schübel, Joachim Feldkamp, Antje Bergmann, Wolfgang Drossard, Karen Voigt
BACKGROUND: The prevalence of latent/subclinical hypothyroidism is between 3% and 10%, according to epidemiologic studies that have been carried out in the USA, the United Kingdom, and Denmark. As persons with latent hypo - thyroidism are often asymptomatic, the diagnosis is often made incidentally in routine laboratory testing. METHODS: This review is based on a selective search in PubMed for publications on the diagnosis and treatment of latent hypothyroidism...
June 23, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28640139/a-prisma-compliant-systematic-review-and-meta-analysis-of-the-relationship-between-thyroid-disease-and-different-levels-of-iodine-intake-in-mainland-china
#15
REVIEW
Wanwen Weng, Mengjie Dong, Jun Zhan, Jun Yang, Bo Zhang, Xingdong Zhao
BACKGROUND: Low-iodine intake has historically been an issue in China, causing widespread iodine deficiency diseases (IDD). China started to introduce universal salt iodization in 1995, but reports of increased thyroid disease are a concern and appropriate levels of iodine intake must be considered. OBJECTIVE: To assess the prevalence of thyroid disease with different urinary iodine concentrations (UICs) in the general population of those residing in mainland China...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28578454/determinants-of-levothyroxine-dose-required-to-achieve-euthyroidism-in-pediatric-population-a-hospital-based-prospective-follow-up-study
#16
Rekha Singh
We analyzed the relation of pretreatment anthropometric measures and serum thyrotropin (TSH) with the levothyroxine requirement. Children (3-18 years) brought to endocrine clinic with newly diagnosed acquired primary hypothyroidism were enrolled consecutively and prospectively with follow-up (July 2014 to April 2016). Children were started on levothyroxine, and dose was adjusted at regular intervals until achieved euthyroidism (serum TSH 0.4 to 4.5 mIU/L). The relationship of age, gender, height, weight, and serum TSH with levothyroxine dose was analyzed by univariate and multivariate regression analysis...
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28566564/effect-of-thyroxin-treatment-on-carotid-intima-media-thickness-cimt-reduction-in-patients-with-subclinical-hypothyroidism-sch-a-meta-analysis-of-clinical-trials
#17
Muhammad Aziz, Yugandhar Kandimalla, Archana Machavarapu, Anshul Saxena, Sankalp Das, Adnan Younus, Michelle Nguyen, Rehan Malik, Dixitha Anugula, Muhammad A Latif, Choudhry Humayun, Idrees M Khan, Ali Adus, Aisha Rasool, Emir Veledar, Khurram Nasir
AIM: Research shows that subclinical hypothyroidism (SCH) is related to an increased carotid intima-media thickness (CIMT), a surrogate marker of subclinical cardiovascular disease (CVD). It is controversial whether or not SCH should be treated to reduce CVD morbidity and mortality. This meta-analysis aimed to determine whether SCH is associated with an increase in CIMT as compared to Euthyroidism (EU) and whether thyroxin (T4) treatment in SCH can reverse the change in CIMT. METHODS: Two independent reviewers conducted an extensive database research up to December 2016...
July 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28553595/does-one-size-fit-everyone-replacement-dose-of-levothyroxine-in-long-standing-primary-hypothyroidism-in-adults
#18
Rekha Singh
OBJECTIVES: The recommended starting dose of levothyroxine (LT4) in primary hypothyroidism is 1.6 μg/kg body weight and is based on presumption of minimal residual thyroid function in autoimmune hypothyroidism. This study aimed at finding the range and determining factors for LT4 dose in long-standing hypothyroidism. METHODS: A cross-sectional study of individuals with primary autoimmune hypothyroidism on LT4 replacement was done between March 2015 and January 2016...
May 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28516372/does-thyroid-dysfunction-increase-the-risk-of-breast-cancer-a-systematic-review-and-meta-analysis
#19
REVIEW
Y Fang, L Yao, J Sun, R Yang, Y Chen, J Tian, K Yang, L Tian
PURPOSE: To investigate the relationship between hypothyroidism, hyperthyroidism, thyroid hormone replacement, and the risk of breast cancer. METHODS: We searched the PubMed, Cochrane Library, EMbase, Web of Science, and China Biology Medicine (CBM) databases through June 2016 to identify researches that assessed the relationship between thyroid dysfunction and the risk of breast cancer together with the impact of thyroid hormone substitution treatment on incidence of breast cancer...
May 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28446514/autoimmune-polyendocrine-syndrome-type-1-in-an-indian-cohort-a-longitudinal-study
#20
Ghazala Zaidi, Vijayalakshmi Bhatia, Saroj K Sahoo, Aditya Narayan Sarangi, Niharika Bharti, Li Zhang, Liping Yu, Daniel Eriksson, Sophie Bensing, Olle Kämpe, Nisha Bharani, Surendra Kumar Yachha, Anil Bhansali, Alok Sachan, Vandana Jain, Nalini Shah, Rakesh Aggarwal, Amita Aggarwal, Muthuswamy Srinivasan, Sarita Agarwal, Eesh Bhatia
OBJECTIVE: Autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal recessive disorder characterized by progressive organ-specific autoimmunity. There is scant information on APS1 in ethnic groups other than European Caucasians. We studied clinical aspects and autoimmune regulator (AIRE) gene mutations in a cohort of Indian APS1 patients. DESIGN: Twenty-three patients (19 families) from six referral centres in India, diagnosed between 1996 and 2016, were followed for [median (range)] 4 (0...
July 2017: Endocrine Connections
keyword
keyword
114752
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"