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Hypothyroidism 2016

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https://www.readbyqxmd.com/read/28217518/a-2016-clinical-practice-pattern-in-the-management-of-primary-hypothyroidism-among-doctors-from-different-clinical-specialties-in-new-delhi
#1
Vineet Surana, Sameer Aggarwal, Deepak Khandelwal, Rajiv Singla, Saptarshi Bhattacharya, Sachin Chittawar, Sanjay Kalra, Deep Dutta
BACKGROUND: This study aimed to document practices in managing hypothyroidism among doctors in New Delhi, with special focus on subclinical hypothyroidism, pregnancy, and old age, and to compare it with global practices. METHODS: During an academic program attended by 394 doctors, all participants were given a questionnaire designed based on thyroid practices survey done by Burch et al. to evaluate the practice patterns. Questions were based on evaluating doctor's preferred choices in diagnosis, therapy, and follow-up of hypothyroidism in different scenarios...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28148249/what-is-the-association-of-hypothyroidism-with-risks-of-cardiovascular-events-and-mortality-a-meta-analysis-of-55-cohort-studies-involving-1-898-314-participants
#2
Yu Ning, Yun J Cheng, Li J Liu, Jaskanwal D S Sara, Zhi Y Cao, Wei P Zheng, Tian S Zhang, Hui J Han, Zhen Y Yang, Yi Zhang, Fei L Wang, Rui Y Pan, Jie L Huang, Ling L Wu, Ming Zhang, Yong X Wei
BACKGROUND: Whether hypothyroidism is an independent risk factor for cardiovascular events is still disputed. We aimed to assess the association between hypothyroidism and risks of cardiovascular events and mortality. METHODS: We searched PubMed and Embase from inception to 29 February 2016. Cohort studies were included with no restriction of hypothyroid states. Priori main outcomes were ischemic heart disease (IHD), cardiac mortality, cardiovascular mortality, and all-cause mortality...
February 2, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28117363/increased-risk-of-gallstone-disease-following-colectomy-for-ulcerative-colitis
#3
Anders Mark-Christensen, Søren Brandsborg, Søren Laurberg, Niels Johansen, Jørn Helmut Pachler, Ole Thorlacius-Ussing, Mie Dilling Kjær, Niels Qvist, Louise Preisler, Jens Hillingsø, Jacob Rosenberg, Peter Jepsen
OBJECTIVES: Biochemical studies suggest that patients who have had a colectomy or restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) are at an increased risk of developing gallstone disease, but epidemiological studies are lacking. We evaluated the risk of gallstone disease following colectomy and IPAA. METHODS: Individuals who had a colectomy were identified from a national cohort of patients with ulcerative colitis (UC), and controls without colectomy were sampled from within the same cohort, matching on gender, calendar year, and year of birth...
January 24, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28056690/2016-guidelines-of-the-american-thyroid-association-for-the-diagnosis-and-management-of-thyroid-disease-during-pregnancy-and-the-postpartum
#4
Erik K Alexander, Elizabeth N Pearce, Gregory A Brent, Rosalind S Brown, Herbert Chen, Chrysoula Dosiou, William Grobman, Peter Laurberg, John H Lazarus, Susan J Mandel, Robin Peeters, Scott Sullivan
BACKGROUND: Thyroid disease in pregnancy is a common clinical problem. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were first published in 2011, significant clinical and scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid disease in women during pregnancy, preconception and the postpartum period...
January 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27927272/ethnic-differences-in-preterm-birth-risks-for-pregnant-women-with-thyroid-dysfunction-or-autoimmunity-a-meta-analysis
#5
Min Li, Shao Wei Wang, Feng Li Wu, Jin Shi, Pu Lin Yu, Xiu Ling Peng, Liang Sun
OBJECTIVE: Abnormal maternal thyroid function is associated with preterm birth. However, this association stays dubious in relevant individual studies for ethnic difference reasons and lack of direct supporting data. This study aimed to evaluate the relationship between preterm birth and thyroid dysfunction or autoimmunity based on ethnic differences. METHODS: Relevant studies were identified through searches of MEDLINE, Excerpta Medica, Wan Fang, China Biological Medicine disc, and China National Knowledge Infrastructure from inception to June 15, 2016...
October 2016: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/27906195/congenital-hypothyroidism-with-delayed-thyroid-stimulating-hormone-elevation-in-premature-infants-born-at-less-than-30-weeks-gestation
#6
D C Kaluarachchi, T T Colaizy, L M Pesce, M Tansey, J M Klein
OBJECTIVE: Congenital hypothyroidism (CH) with delayed thyroid-stimulating hormone (TSH) elevation is a common form of thyroid dysfunction among premature infants. Routine newborn screening (NBS) may miss infants with CH with delayed TSH elevation. The objective of the study is to determine the prevalence of CH with delayed TSH elevation in premature infants and to identify associated risk factors. STUDY DESIGN: Retrospective analysis of serum thyroid function screening (TFS) at day of life 30 in premature infants <30 weeks gestation, admitted to University of Iowa Neonatal Intensive Care Unit between 1 July 2012 to 30 June 2015...
December 1, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27905164/correlative-study-of-dose-to-thyroid-and-incidence-of-subsequent-dysfunction-after-head-and-neck-radiation
#7
Stella Ling, Aashish D Bhatt, Nicole V Brown, Phuong Nguyen, Jennifer A Sipos, Arnab Chakravarti, Yi Rong
BACKGROUND: Thyroid dysfunction is common after radiotherapy (RT) for patients with head and neck cancers. We attempted to discover RT dose parameters that correspond with RT-induced thyroid dysfunction. METHODS: Records of 102 patients who received RT from 2008 to 2010 were reviewed with respect to thyroid function. Abnormalities were grouped in 2 ways: (1) none, transient, or permanent; and (2) overt or subclinical. RESULTS: At median follow-up of 33...
December 1, 2016: Head & Neck
https://www.readbyqxmd.com/read/27899849/statin-therapy-review-of-safety-and-potential-side-effects
#8
REVIEW
Satish Ramkumar, Ajay Raghunath, Sudhakshini Raghunath
BACKGROUND: Hydroxymethyl glutaryl coenzyme A reductase inhibitors, commonly called statins, are some of the most commonly prescribed medications worldwide. Evidence suggests that statin therapy has significant mortality and morbidity benefit for both primary and secondary prevention from cardiovascular disease. Nonetheless, concern has been expressed regarding the adverse effects of long term statin use. The purpose of this article was to review the current medical literature regarding the safety of statins...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27862538/free-thyroid-transfer-short-term-results-of-a-novel-procedure-to-prevent-post-radiation-hypothyroidism
#9
Jeffrey Harris, Brittany Barber, Hani Almarzouki, Rufus Scrimger, Jacques Romney, Daniel O'Connell, Mark Urken, Hadi Seikaly
BACKGROUND: The incidence of radiation-induced hypothyroidism (RIH) in patients with head and neck cancer is >50%. The purpose of this study was to assess the long-term efficacy of free thyroid transfer (FTT) for prevention of RIH in patients with head and neck cancer. METHODS: Hemithyroid dissection was completed in 10 patients with advanced head and neck cancer undergoing ablation, radial forearm free flap (RFFF) reconstruction, and postoperative radiotherapy (RT)...
November 15, 2016: Head & Neck
https://www.readbyqxmd.com/read/27852042/toxicity-profile-of-approved-anti-pd-1-monoclonal-antibodies-in-solid-tumors-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#10
REVIEW
Ricardo Costa, Benedito A Carneiro, Mark Agulnik, Alfred W Rademaker, Sachin G Pai, Victoria M Villaflor, Massimo Cristofanilli, Jeffrey A Sosman, Francis J Giles
PURPOSE: Nivolumab and pembrolizumab are antibodies against the programmed-death-receptor- 1 (PD-1) which are associated with distinct immune related adverse effects (AEs). This meta-analysis of randomized clinical trials aims to summarize current knowledge regarding the toxicity profile of these agents. METHODS: PubMed search was conducted in February of 2016. The randomized trials needed to have at least one of the study arms consisting of nivolumab or pembrolizumab monotherapy and a control arm containing no anti-PD-1 therapy...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/27843806/a-2016-italian-survey-about-the-clinical-use-of-selenium-in-thyroid-disease
#11
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Claudio Marcocci, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: Selenium (Se) is a trace element that plays key roles in thyroid physiology. Se deficiency is associated with increased risk of thyroid disease. Some evidence suggests that Se supplementation may be beneficial in autoimmune thyroid disease (either hypo- or hyperthyroidism). OBJECTIVES: We sought to examine the use of Se in daily clinical practice among Italian endocrinologists. METHODS: Members of the Associazione Medici Endocrinologi (AME) were invited to participate in a web-based survey investigating the use of Se in different clinical conditions...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27828692/congenital-hypothyroidism-polish-recommendations-for-therapy-treatment-monitoring-and-screening-tests-in-special-categories-of-neonates-with-increased-risk-of-hypothyroidism
#12
Anna Małgorzata Kucharska, Iwona Beń-Skowronek, Mieczysław Walczak, Mariusz Ołtarzewski, Mieczysław Szalecki, Teresa Jackowska, Andrzej Lewiński, Artur Bossowski
Proper treatment of congenital hypothyroidism warrants normal intellectual and physical development. This paper introduces the principles of treatment of congenital hypothyroidism, the recommended levothyroxine dosage, and the aims of therapy with its justification. The principles of treatment, specialist care of the patient, and methods used to evaluate therapeutic effects are described. Based on these data, recommendations concerning treatment and its monitoring in patients with congenital hypothyroidism are formulated...
2016: Endokrynologia Polska
https://www.readbyqxmd.com/read/27828690/immunoglobulin-g4-related-thyroid-disorders-diagnostic-challenges-and-clinical-outcomes
#13
Deep Dutta, Arvind Ahuja, Chitra Selvan
Ig-G4 related disease (IgG4RD) is a heterogeneous disorder with multi-organ involvement recognised as a separate entity at the start of this century only. It is currently one of the hottest areas of clinical and translational research across specialties. Thyroid involvement in IgG4RD is rare, believed to occur in less than 4% of cases, may be isolated or may be associated with other organ involvement. As of today Riedel's thyroiditis, fibrosing variant of Hashimoto's thyroiditis, and few patients of Graves' orbitopathy represent the types of IgG4-related thyroid disease (IgG4RTD)...
2016: Endokrynologia Polska
https://www.readbyqxmd.com/read/27756664/endoscopic-endonasal-versus-microsurgical-transsphenoidal-approach-for-growth-hormone-secreting-pituitary-adenomas-systematic-review-and-meta-analysis
#14
Kevin Phan, Joshua Xu, Rajesh Reddy, Piyush Kalakoti, Anil Nanda, Jacob Fairhall
BACKGROUND: The pituitary adenoma causing acromegaly is typically resected through a transsphenoidal approach and visualized with an operating microscope or endoscope. We undertook a systematic review and meta-analysis examining the clinical efficacy of endoscopic and microsurgical approaches. METHODS: Relevant studies using either endoscopic or microscopic transsphenoidal approaches for growth hormone pituitary adenomas were identified until February 2016. Data were extracted and analyzed according to predefined clinical end points...
January 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27749132/optimal-management-of-hypothyroidism-incremental-improvements-for-use-in-2016-and-beyond
#15
James V Hennessey
FT3 = free T3 FT4 = free T4 LT3 = tri-iodothyronine LT4 = levothyroxine TSH = thyroid-stimulating hormone.
November 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27744598/association-of-parathyroid-carcinoma-and-thyroid-disorders-a-clinical-review
#16
REVIEW
Alfredo Campennì, Salvatore Giovinazzo, Salvatore Antonio Pignata, Francesca Di Mauro, Domenico Santoro, Lorenzo Curtò, Francesco Trimarchi, Rosaria Maddalena Ruggeri, Sergio Baldari
Parathyroid carcinoma is a rare malignancy, which usually occurs as a sporadic disease, and less frequently in the setting of genetic syndromes. Despite the association of parathyroid and thyroid disorders being quite common, the coexistence of parathyroid carcinoma and thyroid disease is rare. We reviewed the pertinent literature. The terms "parathyroid carcinoma" and "thyroid disease, hyperthyroidism, thyrotoxicosis, hypothyroidism, thyroid nodule(s), Graves' disease, autonomously functioning thyroid nodules" were used both separately and in reciprocal conjunction to search MEDLINE for articles published from January 2007 to March 2016...
October 15, 2016: Endocrine
https://www.readbyqxmd.com/read/27730067/antithyroid-drugs-in-graves-disease-are-we-stretching-it-too-far
#17
Muthukrishnan Jayaraman, Anil Kumar Pawah, C S Narayanan
INTRODUCTION: Early and durable achievement of euthyroid or hypothyroid status with low likelihood of relapse is the key to effective treatment of Graves' disease (GD). Although antithyroid drugs (ATDs) are commonly used first-line agents, likelihood of remission remains highest with radioactive iodine (RAI) therapy and surgery. Data regarding efficacy and economical superiority of RAI therapy over ATDs are lacking from India. This study was designed to study the response to long-term (>12 months) use of ATDs in GD with respect to attainment of remission and to compare the cost of treatment with ATDs versus RAI therapy beyond 12 months...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27726750/imaging-findings-of-metabolic-bone-disease
#18
Connie Y Chang, Daniel I Rosenthal, Deborah M Mitchell, Atsuhiko Handa, Susan V Kattapuram, Ambrose J Huang
Metabolic bone diseases are a diverse group of diseases that result in abnormalities of (a) bone mass, (b) structure mineral homeostasis, (c) bone turnover, or (d) growth. Osteoporosis, the most common metabolic bone disease, results in generalized loss of bone mass and deterioration in the bone microarchitecture. Impaired chondrocyte development and failure to mineralize growth plate cartilage in rickets lead to widened growth plates and frayed metaphyses at sites of greatest growth. Osteomalacia is the result of impaired mineralization of newly formed osteoid, which leads to characteristic Looser zones...
October 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27702319/letter-to-the-editor-hypothyroidism-following-hemithyroidectomy-incidence-risk-factors-and-clinical-characteristics-ahn-d-sohn-jh-jeon-jh-hypothyroidism-following-hemithyroidectomy-incidence-risk-factors-and-clinical-characteristics-j-clin-endocrinol-metab
#19
https://www.readbyqxmd.com/read/27648188/evaluation-of-serum-levels-in-t3-t4-and-tsh-in-beta-thalassemic-patients-referred-to-the-abuzar-hospital-in-ahwaz
#20
Zari Tahannejad Asad, Majid Ghazanfari, Seyyed Nima Naleini, Azam Sabagh, Wesam Kooti
INTRODUCTION: Regarding the functioning of the endocrine system, and especially in the thyroid of patients with thalassemia, multiple studies in different parts of the world have reported conflicting results. The aim of this study was to assess the levels of thyroid hormones and TSH in beta-thalassemic patients in the city of Ahwaz. METHODS: In this matched case-control study, 105 patients in the case group and 105 subjects as controls were randomly selected from clients referred to the Abuzar hospital in 2015-2016...
July 2016: Electronic Physician
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