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zika vaccine

Richard B Kennedy
No abstract text is available yet for this article.
October 13, 2016: EBioMedicine
Sean Ekins, John Liebler, Bruno J Neves, Warren G Lewis, Megan Coffee, Rachelle Bienstock, Christopher Southan, Carolina H Andrade
The Zika virus (ZIKV) is a flavivirus of the family Flaviviridae, which is similar to dengue virus, yellow fever and West Nile virus. Recent outbreaks in South America, Latin America, the Caribbean and in particular Brazil have led to concern for the spread of the disease and potential to cause Guillain-Barré syndrome and microcephaly. Although ZIKV has been known of for over 60 years there is very little in the way of knowledge of the virus with few publications and no crystal structures. No antivirals have been tested against it either in vitro or in vivo...
2016: F1000Research
Aaron M Fleming, Yun Ding, Anton Alenko, Cynthia J Burrows
Zika virus has emerged as a global concern because neither a vaccine nor antiviral compounds targeting it exist. A structure for the positive-sense RNA genome has not been established, leading us to look for potential G-quadruplex sequences (PQS) in the genome. The analysis identified >60 PQSs in the Zika genome. To minimize the PQS population, conserved sequences in the Flaviviridae family were found by sequence alignment, identifying seven PQSs in the prM, E, NS1, NS3, and NS5 genes. Next, alignment of 78 Zika strain genomes identified a unique PQS near the end of the 3'-UTR...
October 14, 2016: ACS Infectious Diseases
Abdelrahman Ibrahim Abushouk, Ahmed Negida, Hussien Ahmed
The current outbreak of Zika virus (ZIKV) in South America is one of the most serious public health emergencies since the Ebola outbreak of West Africa [2014]. ZIKV belongs to the flaviviridae family and has two lineages (Asian and African). The virus was first discovered in Uganda [1947] and the first human infection was identified in Nigeria [1952]. The current epidemic is the third of its type after that of Yap Island, Micronesia [2007] and French Polynesia [2013]. Phylogenetic studies revealed that the current strain shares about 99...
October 3, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
David S Younger
Zika virus is an arbovirus belonging to the Flaviviridae family known to cause mild clinical symptoms similar to those of dengue and chikungunya. Zika is transmitted by different species of Aedes mosquitoes. Nonhuman primates and possibly rodents play a role as reservoirs. Direct interhuman transmission has also been reported. Human cases have been reported in Africa and Asia, Easter Island, the insular Pacific region, and Brazil. Its clinical profile is that of a dengue-like febrile illness, but recently associated Guillain-Barre syndrome and microcephaly have appeared...
November 2016: Neurologic Clinics
Eun Kim, Geza Erdos, Shaohua Huang, Thomas Kenniston, Louis D Falo, Andrea Gambotto
Since it emerged in Brazil in May 2015, the mosquito-borne Zika virus (ZIKV) has raised global concern due to its association with a significant rise in the number of infants born with microcephaly and neurological disorders such as Guillain-Barré syndrome. We developed prototype subunit and adenoviral-based Zika vaccines encoding the extracellular portion of the ZIKV envelope gene (E) fused to the T4 fibritin foldon trimerization domain (Efl). The subunit vaccine was delivered intradermally through carboxymethyl cellulose microneedle array (MNA)...
October 3, 2016: EBioMedicine
Angela Ferreira Lopes de Teive E Argolo, Valéria Christina de Rezende Féres, Marli Tenório Cordeiro, Lucimeire Antonelli da Silveira, Adriana Oliveira Guilarde, Ernesto Torres de Azevedo Marques, Wayner Vieira de Souza, Celina Maria Turchi Martelli
BACKGROUND: This study aims to identify dengue neutralizing antibody response in patients with dengue from a well-characterized cohort during an outbreak in central Brazil, 2012-2013. METHODS: We analyzed paired samples from 40 patients with severe dengue and 20 patients with dengue. Eligibility criteria were: IgM, NS1Ag and/or RT-PCR positivity and positive IgG result. Plaque reduction neutralization test (PRNT50) from DENV-1 to DENV-4 was performed to identify serotype-specific NAbs response...
October 7, 2016: BMC Infectious Diseases
Gregory Valentine, Lucila Marquez, Mohan Pammi
Zika Virus (ZIKV), previously the cause of only rare and sporadic human infections, is now considered a Public Health Emergency of International Concern. Over the past two years, ZIKV has become a pandemic encompassing much of the Americas. ZIKV is now proven to cause microcephaly and ophthalmic anomalies in the newborn. Hydrops fetalis, developmental delay, and other anomalies are increasingly being attributed to ZIKV infection in fetuses and neonates. Sequelae of congenital infection and rapid spread of ZIKV throughout the Americas has catapulted Zika virus concerns to the forefront of the medical community...
October 7, 2016: Expert Review of Anti-infective Therapy
Kimberly A Dowd, Sung-Youl Ko, Kaitlyn M Morabito, Eun Sung Yang, Rebecca S Pelc, Christina R DeMaso, Leda R Castilho, Peter Abbink, Michael Boyd, Ramya Nityanandam, David N Gordon, John Robert Gallagher, Xuejun Chen, John-Paul Todd, Yaroslav Tsybovsky, Audray Harris, Yan-Jang S Huang, Stephen Higgs, Dana L Vanlandingham, Hanne Andersen, Mark G Lewis, Rafael De La Barrera, Kenneth H Eckels, Richard G Jarman, Martha C Nason, Dan H Barouch, Mario Roederer, Wing-Pui Kong, John R Mascola, Theodore C Pierson, Barney S Graham
Zika virus (ZIKV) was identified as a cause of congenital disease during the explosive outbreak in the Americas and Caribbean that began in 2015. Because of the ongoing fetal risk from endemic disease and travel-related exposures, a vaccine to prevent viremia in women of childbearing age and their partners is imperative. We found that vaccination with DNA expressing the premembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after ZIKV challenge correlated with serum neutralizing activity...
October 14, 2016: Science
Giovanni Benelli, Claire L Jeffries, Thomas Walker
Mosquitoes represent the major arthropod vectors of human disease worldwide transmitting malaria, lymphatic filariasis, and arboviruses such as dengue virus and Zika virus. Unfortunately, no treatment (in the form of vaccines or drugs) is available for most of these diseases andvectorcontrolisstillthemainformofprevention. Thelimitationsoftraditionalinsecticide-based strategies, particularly the development of insecticide resistance, have resulted in significant efforts to develop alternative eco-friendly methods...
October 3, 2016: Insects
Tatjana Avšic Županc, Miroslav Petrovec
Zika virus is a mosquito-borne flavivirus that represents a public health emergency at the ongoing epidemic. This obscure virus was limited to sporadic cases in Africa and Asia, until the emergence of Zika virus in Brazil in 2015, when it rapidly spread throughout the Americas. Most Zika virus infections are subclinical or characterized by mild febrile illness. However, neurological complications, including Guillain-Barré syndrome in adults, and congenital anomalies, including microcephaly in babies born to infected mothers, raised a grave concern...
December 1, 2016: Zdravstveno Varstvo
Theodore C Pierson, Barney S Graham
The emergence of Zika virus in the Americas and Caribbean created an urgent need for vaccines to reduce transmission and prevent disease, particularly the devastating neurodevelopmental defects that occur in utero. Rapid advances in Zika immunity and the development of vaccine candidates provide cautious optimism that preventive measures are possible.
September 28, 2016: Cell
Xiao-Feng Li, Hao-Long Dong, Xing-Yao Huang, Ye-Feng Qiu, Hong-Jiang Wang, Yong-Qiang Deng, Na-Na Zhang, Qing Ye, Hui Zhao, Zhong-Yu Liu, Hang Fan, Xiao-Ping An, Shi-Hui Sun, Bo Gao, Yun-Zhi Fa, Yi-Gang Tong, Fu-Chun Zhang, George F Gao, Wu-Chun Cao, Pei-Yong Shi, Cheng-Feng Qin
Animal models are critical to understand disease and to develop countermeasures for the ongoing epidemics of Zika virus (ZIKV). Here we report a non-human primate model using a 2016 contemporary clinical isolate of ZIKV. Upon subcutaneous inoculation, rhesus macaques developed fever and viremia, with robust excretion of ZIKV RNA in urine, saliva, and lacrimal fluid. Necropsy of two infected animals revealed that systematic infections involving central nervous system and visceral organs were established at the acute phrase...
September 23, 2016: EBioMedicine
Stephen J Thomas, Maïna L'Azou, Alan D T Barrett, Nicholas A C Jackson
Studies have demonstrated that various Zika virus (ZIKV) vaccine constructs generate protective immune responses in mice and nonhuman primates, and two DNA ZIKV vaccine candidates have entered phase 1 human safety testing ( numbers, NCT01099852 and NCT02840487). ZIKV vaccine..
September 29, 2016: New England Journal of Medicine
Hilary D Marston, Nicole Lurie, Luciana L Borio, Anthony S Fauci
The rapid spread of Zika virus through the Americas and its devastating consequences for pregnant women and infants have precipitated an international, multisectoral response. Current prevention strategies focus on mosquito control, protection of the blood supply, barrier protection during sex, and..
September 29, 2016: New England Journal of Medicine
Indra Vythilingam, Jamal I-C Sam, Yoke F Chan, Loke T Khaw, Wan Y Wan Sulaiman
Zika virus (ZIKV) has now become a global public health concern. The vectors for ZIKV are Aedes aegypti and A. albopictus. Both these mosquitoes are predominant in Southeast Asia and are also responsible for the spread of other arboviral diseases like dengue virus and chikungunya virus. The incidence of dengue has been increasing over the years and this is of concern to public health workers. Simple laboratory tools for the detection of ZIKV is also lacking. In the absence of drugs and vaccine for these arboviral diseases, vector control is the main option for surveillance and control...
2016: Frontiers in Microbiology
Jennifer Abbasi
No abstract text is available yet for this article.
September 27, 2016: JAMA: the Journal of the American Medical Association
Berlin Londono-Renteria, Andrea Troupin, Tonya M Colpitts
Infectious diseases caused by arboviruses (viruses transmitted by arthropods) are undergoing unprecedented epidemic activity and geographic expansion. With the recent introduction of West Nile virus (1999), chikungunya virus (2013) and Zika virus (2015) to the Americas, stopping or even preventing the expansion of viruses into susceptible populations is an increasing concern. With a few exceptions, available vaccines protecting against arboviral infections are nonexistent and current disease prevention relies on vector control interventions...
2016: Parasites & Vectors
Qanta A Ahmed, Ziad A Memish
No abstract text is available yet for this article.
September 20, 2016: Travel Medicine and Infectious Disease
James W Mains, Corey L Brelsfoard, Robert I Rose, Stephen L Dobson
Dengue, chikungunya and zika viruses are pathogens with an increasing global impact. In the absence of an approved vaccine or therapy, their management relies on controlling the mosquito vectors. But traditional controls are inadequate, and the range of invasive species such as Aedes albopictus (Asian Tiger Mosquito) is expanding. Genetically modified mosquitoes are being tested, but their use has encountered regulatory barriers and public opposition in some countries. Wolbachia bacteria can cause a form of conditional sterility, which can provide an alternative to genetic modification or irradiation...
2016: Scientific Reports
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