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https://www.readbyqxmd.com/read/29780762/framing-and-visual-type-effect-on-future-zika-vaccine-uptake-intent
#1
Jeanine P D Guidry, Kellie E Carlyle, Jessica G LaRose, Paul Perrin, Mark Ryan, Marcus Messner, Jay Adams
Introduction: The Zika virus is associated with the birth defect microcephaly, and while a vaccine was not available in early- 2017, several were under development. This study's purpose was to identify effective communication strategies to promote uptake of a new vaccine, particularly among women of reproductive age. Design and methods: In order to study the effects of Zika message framing (gain vs . loss) and visual type (photo vs . infographic) on future Zika vaccine uptake intent, a 2×2 between-subjects experiment was performed via an online survey in 2017 among 339 U...
February 5, 2018: Journal of Public Health Research
https://www.readbyqxmd.com/read/29779454/vaccinia-based-vaccines-to-biothreat-and-emerging-viruses
#2
Les P Nagata, Chad R Irwin, Wei-Gang Hu, David H Evans
The past few years have seen a rash of emerging viral diseases, including the Ebola crisis in West Africa, the pandemic spread of chikungunya, and the recent explosion of Zika in South America. Vaccination is the most reliable and cost-effective method of control of infectious diseases, however, there is often a long delay in production and approval in getting new vaccines to market. Vaccinia was the first vaccine developed for the successful eradication of smallpox and has properties that make it attractive as a universal vaccine vector...
May 21, 2018: Biotechnology & Genetic Engineering Reviews
https://www.readbyqxmd.com/read/29774519/zika-virus-baculovirus-expressed-virus-like-particles-induce-neutralizing-antibodies-in-mice
#3
Shiyu Dai, Tao Zhang, Yanfang Zhang, Hualin Wang, Fei Deng
The newly emerged mosquito-borne Zika virus (ZIKV) strains pose a global challenge owing to its ability to cause microcephaly and neurological disorders. Several ZIKV vaccine candidates have been proposed, including inactivated and live attenuated virus vaccines, vector-based vaccines, DNA and RNA vaccines. These have been shown to be efficacious in preclinical studies in mice and nonhuman primates, but their use will potentially be a threat to immunocompromised individuals and pregnant women. Virus-like particles (VLPs) are empty particles composed merely of viral proteins, which can serve as a safe and valuable tool for clinical prevention and treatment strategies...
May 17, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29773774/us-and-cuban-scientists-forge-collaboration-on-arbovirus-research
#4
Jorge Pérez-Ávila, Maria G Guzmán-Tirado, Jorge Fraga-Nodarse, Gray Handley, James Meegan, Jose L Pelegrino-Martínez de la Cotera, Anthony S Fauci
After December 17, 2014, when the US and Cuban governments announced their intent to restore relations, the two countries participated in various exchange activities in an effort to encourage cooperation in public health, health research and biomedical sciences. The conference entitled Exploring Opportunities for Arbovirus Research Collaboration, hosted at Havana's Hotel Nacional, was part of these efforts and was the first major US-Cuban scientific conference in over 50 years. Its purpose was to share information about current arbovirus research and recent findings, and to explore opportunities for future joint research...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29758005/a-review-of-the-ongoing-research-on-zika-virus-treatment
#5
REVIEW
Suely da Silva, Daniel Oliveira Silva Martins, Ana Carolina Gomes Jardim
The Zika fever is an arboviral disease resulting from the infection with Zika virus (ZIKV). The virus is transmitted to humans by the bite of Aedes mosquitos, mainly Aedes aegypti and Aedes albopictus . ZIKV has been detected for decades in African and Asian regions and, since 2007, has spread to other continents; among them, infections are most reported in the Americas. This can be explained by the presence of vectors in highly populated and tropical regions where people are susceptible to contamination. ZIKV has been considered by the World Health Organization a serious public health problem because of the increasing number of cases of congenital malformation and neurological disorders related to its infection, such as microcephaly, Guillain⁻Barré syndrome, meningoencephalitis, and myelitis...
May 14, 2018: Viruses
https://www.readbyqxmd.com/read/29757218/detection-of-specific-zikv-igm-in-travelers-using-a-multiplexed-flavivirus-microsphere-immunoassay
#6
Carmel T Taylor, Ian M Mackay, Jamie L McMahon, Sarah L Wheatley, Peter R Moore, Mitchell J Finger, Glen R Hewitson, Frederick A Moore
Zika virus (ZIKV) has spread widely in the Pacific and recently throughout the Americas. Unless detected by RT-PCR, confirming an acute ZIKV infection can be challenging. We developed and validated a multiplexed flavivirus immunoglobulin M (IgM) microsphere immunoassay (flaviMIA) which can differentiate ZIKV-specific IgM from that due to other flavivirus infections in humans. The flaviMIA bound 12 inactivated flavivirus antigens, including those from ZIKV and yellow fever virus (YFV), to distinct anti-flavivirus antibody coupled beads...
May 12, 2018: Viruses
https://www.readbyqxmd.com/read/29753607/maternal-immunization-with-a-dna-vaccine-candidate-elicits-specific-passive-protection-against-post-natal-zika-virus-infection-in-immunocompetent-balb-c-mice
#7
Ran Wang, Xianzheng Liao, Dongying Fan, Lei Wang, Ji Song, Kaihao Feng, Mingyuan Li, Peigang Wang, Hui Chen, Jing An
Zika virus (ZIKV) infection is closely associated in the fetus with microcephaly and in the adults with Guillain-Barré syndrome and even male infertility. It is an urgent international priority to develop a safe and effective vaccine that offers protection to both women of childbearing age and their children. In this study, female immunocompetent BALB/c mice were immunized with a DNA-based vaccine candidate, pVAX1-ZME, expressing the prM/E protein of ZIKV, and the immunogenicity for maternal mice and the post-natal protection for suckling mice were evaluated...
May 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29753210/zika-virus-vaccines-immune-response-current-status-and-future-challenges
#8
REVIEW
Justin M Richner, Michael S Diamond
Zika virus (ZIKV) is the most recent mosquito-transmitted virus to cause a global health crisis following its entrance into a naïve population in the Western Hemisphere. Once the ZIKV outbreak began investigators rapidly established small and large animal models of pathogenesis, developed a number candidate vaccines using different platforms, and defined mechanisms of protection. In this review, we characterize the adaptive immune response elicited by ZIKV infections and vaccines, the status of ongoing clinical trials in humans, and discuss future challenges within the field...
May 9, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29751638/zika-virus-trafficking-and-interactions-in-the-human-male-reproductive-tract
#9
REVIEW
Lucia Regina Cangussu da Silva
Sexual transmission of Zika virus (ZIKV) is a matter of great concern. Infectious viral particles can be shed in semen for as long as six months after infection and can be transferred to male and female sexual partners during unprotected sexual intercourse. The virus can be found inside spermatozoa and could be directly transferred to the oocyte during fertilization. Sexual transmission of ZIKV can contribute to the rise in number of infected individuals in endemic areas as well as in countries where the mosquito vector does not thrive...
May 11, 2018: Pathogens
https://www.readbyqxmd.com/read/29751486/current-strategies-for-inhibition-of-chikungunya-infection
#10
REVIEW
Bharat Bhusan Subudhi, Soma Chattopadhyay, Priyadarsee Mishra, Abhishek Kumar
Increasing incidences of Chikungunya virus (CHIKV) infection and co-infections with Dengue/Zika virus have highlighted the urgency for CHIKV management. Failure in developing effective vaccines or specific antivirals has fuelled further research. This review discusses updated strategies of CHIKV inhibition and provides possible future directions. In addition, it analyzes advances in CHIKV lifecycle, drug-target development, and potential hits obtained by in silico and experimental methods. Molecules identified with anti-CHIKV properties using traditional/rational drug design and their potential to succeed in subsequent stages of drug development have also been discussed...
May 3, 2018: Viruses
https://www.readbyqxmd.com/read/29747736/infections-in-pregnancy-and-the-role-of-vaccines
#11
REVIEW
Kimberly B Fortner, Claudia Nieuwoudt, Callie F Reeder, Geeta K Swamy
Pregnant women are at risk for infection and may have significant morbidity or mortality. Influenza, pertussis, zika, and cytomegalovirus produce mild or asymptomatic illness in the mother, but have profound implications for her fetus. Maternal immunization can prevent or mitigate infections in pregnant women and their infants. The Advisory Committee of Immunization Practices recommends 2 vaccines during pregnancy: inactivated influenza, and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis during pregnancy...
June 2018: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/29745863/generation-and-comparative-genomics-of-synthetic-dengue-viruses
#12
Eli Goz, Yael Tsalenchuck, Rony Oren Benaroya, Zohar Zafrir, Shimshi Atar, Tahel Altman, Justin Julander, Tamir Tuller
BACKGROUND: Synthetic virology is an important multidisciplinary scientific field, with emerging applications in biotechnology and medicine, aiming at developing methods to generate and engineer synthetic viruses. In particular, many of the RNA viruses, including among others the Dengue and Zika, are widespread pathogens of significant importance to human health. The ability to design and synthesize such viruses may contribute to exploring novel approaches for developing vaccines and virus based therapies...
May 8, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29742375/investigational-testing-for-zika-virus-among-u-s-blood-donors
#13
MULTICENTER STUDY
Paula Saá, Melanie Proctor, Gregory Foster, David Krysztof, Colleen Winton, Jeffrey M Linnen, Kui Gao, Jaye P Brodsky, Ronald J Limberger, Roger Y Dodd, Susan L Stramer
BACKGROUND: Because of the potential severe clinical consequences of Zika virus (ZIKV) infection, the large numbers of asymptomatic travelers returning from ZIKV-active areas, the detection of ZIKV nucleic acid in blood, and reports of transmission of ZIKV through transfusion, in 2016 the Food and Drug Administration released recommendations for individual-unit nucleic acid testing to minimize the risk of transmission of ZIKV through blood transfusions. METHODS: The American Red Cross implemented investigational screening of donated blood for ZIKV RNA by means of transcription-mediated amplification (TMA)...
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29740962/identification-of-broad-spectrum-dengue-zika-virus-replication-inhibitors-by-functionalization-of-quinoline-and-2-6-diaminopurine-scaffolds
#14
Suzanne J F Kaptein, Paolo Vincetti, Emmanuele Crespan, Jorge I Armijos-Rivera, Gabriele Costantino, Giovanni Maga, Johan Neyts, Marco Radi
Social and demographic changes over the past 50 years resulted in important outbreaks of arboviruses such as dengue virus (DENV) and Zika virus (ZIKV) all over the world. Despite such potential threat, no approved drugs or fully protective vaccines are available to counteract DENV and ZIKV spreading. The development of "broad spectrum" antivirals (BSAs) targeting common components of multiple viruses, can be a more effective strategy to limit the rapid rise of emerging viral pathogens than the classic "one-bug/one-drug" approach...
May 9, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29728911/nanoparticle-vaccines-against-viral-infections
#15
REVIEW
Fernando B Sulczewski, Raquel B Liszbinski, Pedro R T Romão, Luiz Carlos Rodrigues Junior
Despite numerous efforts, we still do not have prophylactic vaccines for many clinically relevant viruses, such as HIV, hepatitis C virus, Zika virus, and respiratory syncytial virus. Several factors have contributed to the current lack of effective vaccines, including the high rate of viral mutation, low immunogenicity of recombinant viral antigens, instability of viral antigenic proteins administered in vivo, sophisticated mechanisms of viral immune evasion, and inefficient induction of mucosal immunity by vaccine models studied to date...
May 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29723973/comparative-pathogenesis-of-asian-and-african-lineage-zika-virus-in-indian-rhesus-macaque-s-and-development-of-a-non-human-primate-model-suitable-for-the-evaluation-of-new-drugs-and-vaccines
#16
Jonathan O Rayner, Raj Kalkeri, Scott Goebel, Zhaohui Cai, Brian Green, Shuling Lin, Beth Snyder, Kimberly Hagelin, Kevin B Walters, Fusataka Koide
The establishment of a well characterized non-human primate model of Zika virus (ZIKV) infection is critical for the development of medical interventions. In this study, challenging Indian rhesus macaques (IRMs) with ZIKV strains of the Asian lineage resulted in dose-dependent peak viral loads between days 2 and 5 post infection and a robust immune response which protected the animals from homologous and heterologous re-challenge. In contrast, viremia in IRMs challenged with an African lineage strain was below the assay’s lower limit of quantitation, and the immune response was insufficient to protect from re-challenge...
May 1, 2018: Viruses
https://www.readbyqxmd.com/read/29723166/vital-signs-trends-in-reported-vectorborne-disease-cases-united-states-and-territories-2004-2016
#17
Ronald Rosenberg, Nicole P Lindsey, Marc Fischer, Christopher J Gregory, Alison F Hinckley, Paul S Mead, Gabriela Paz-Bailey, Stephen H Waterman, Naomi A Drexler, Gilbert J Kersh, Holley Hooks, Susanna K Partridge, Susanna N Visser, Charles B Beard, Lyle R Petersen
INTRODUCTION: Vectorborne diseases are major causes of death and illness worldwide. In the United States, the most common vectorborne pathogens are transmitted by ticks or mosquitoes, including those causing Lyme disease; Rocky Mountain spotted fever; and West Nile, dengue, and Zika virus diseases. This report examines trends in occurrence of nationally reportable vectorborne diseases during 2004-2016. METHODS: Data reported to the National Notifiable Diseases Surveillance System for 16 notifiable vectorborne diseases during 2004-2016 were analyzed; findings were tabulated by disease, vector type, location, and year...
May 4, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29720583/ce-blast-makes-it-possible-to-compute-antigenic-similarity-for-newly-emerging-pathogens
#18
Tianyi Qiu, Yiyan Yang, Jingxuan Qiu, Yang Huang, Tianlei Xu, Han Xiao, Dingfeng Wu, Qingchen Zhang, Chen Zhou, Xiaoyan Zhang, Kailin Tang, Jianqing Xu, Zhiwei Cao
Major challenges in vaccine development include rapidly selecting or designing immunogens for raising cross-protective immunity against different intra- or inter-subtypic pathogens, especially for the newly emerging varieties. Here we propose a computational method, Conformational Epitope (CE)-BLAST, for calculating the antigenic similarity among different pathogens with stable and high performance, which is independent of the prior binding-assay information, unlike the currently available models that heavily rely on the historical experimental data...
May 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29720077/australian-paediatric-surveillance-unit-annual-report-2016
#19
Marie Deverell, Amy Phu, Yvonne Zurynski, Elizabeth Elliott
This report summarises the cases reported to the Australian Paediatric Surveillance Unit (APSU) of rare infectious diseases or rare complications of more common infectious diseases in children. During the calendar year 2016, there were approximately 1500 paediatricians reporting to the APSU and the monthly report card return rate was 90%. APSU continued to provide unique national data on the perinatal exposure to HIV, congenital rubella, congenital cytomegalovirus, neonatal and infant herpes simplex virus, and congenital and neonatal varicella...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29719255/a-single-injection-of-human-neutralizing-antibody-protects-against-zika-virus-infection-and-microcephaly-in-developing-mouse-embryos
#20
Cui Li, Fei Gao, Lei Yu, Ruoke Wang, Yisheng Jiang, Xuanling Shi, Chibiao Yin, Xiaoping Tang, Fuchun Zhang, Zhiheng Xu, Linqi Zhang
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that is generally benign in humans. However, an emergent strain of ZIKV has become widespread, causing severe pre- and post-natal neurological defects. There is now an urgent need for prophylactic and therapeutic agents. To address this, we investigated six human monoclonal antibodies with ZIKV epitope specificity and neutralizing activity in mouse models of ZIKV infection and microcephaly. A single intraperitoneal injection of these antibodies conveyed distinct levels of adult and in utero protection from ZIKV infection, which closely mirrored their respective in vitro neutralizing activities...
May 1, 2018: Cell Reports
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