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Esophagogastric junction adenocarcinoma

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https://www.readbyqxmd.com/read/28323156/prognostic-significance-of-the-number-of-lymph-nodes-examined-in-node-negative-siewert-type-ii-esophagogastric-junction-adenocarcinoma
#1
Xian-Ning Wu, Chang-Qing Liu, Jie-Yong Tian, Ming-Fa Guo, Mei-Qing Xu
BACKGROUND: Involvement status of lymph node (LN) is one of the most important prognostic factors for esophagogastric junction (EGJ) adenocarcinoma. However, the prognostic value of the number of examined LNs remains unclear in node-negative (pN0) Siewert type II EGJ adenocarcinoma. METHODS: A cohort of 262 patients who underwent curative surgery for pN0 Siewert type II EGJ adenocarcinoma from January 2000 to August 2013 were retrospectively analyzed from high-volume center database...
March 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28316217/-comparison-of-the-effect-of-lymph-node-dissection-performed-by-ivor-lewis-or-left-sided-thoracic-esophagogastrectomy-for-siewert-type-%C3%A2-adenocarcinoma-of-the-esophagogastric-junction
#2
X F Duan, L Gong, M Q Ma, J Yue, P Tang, X B Shang, H J Jiang, Z T Yu
Objective: To compare the extent of lymphadenectomy and postoperative complications between Ivor-Lewis procedure and left sided thoracotomy in patients with Siewert type Ⅱ adenocarcinoma of the esophagogastric junction (AEG). Methods: The clinical data of 101 patients with Siewert type Ⅱ EG who received surgical treatment between January 2014 and September 2015 in the Department of Esophageal Cancer, Tianjin Medical University Cancer Hospital were analyzed retrospectively. These patients were divided into Ivor-Lewis group (IL, n=38) and left- sided thoracotomy group (LT, n=63) according to the operation mode...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28297830/-ct-typing-and-surgical-approach-for-adenocarcinoma-of-the-esophagogastric-junction
#3
Y Z Zhao, G S Han, P F Ma, J Li, C Y Liu, M K Huo
Objective: To investigate the feasibility, safety and efficacy of preoperative CT in the classification of adenocarcinoma of the esophagogastric junction. Methods: A total of 517 consecutive patients from May 2012 to June 2016 with esophagogastric junction carcinoma in the department of general surgery of Henan Cancer Hospital was retrospectively analyzed, according to the clinical pathological data of three type four layer method and statistics of various types of surgery in patients with preoperative enhanced CT...
March 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28292272/comparison-of-five-tumor-regression-grading-systems-for-gastric-adenocarcinoma-after-neoadjuvant-chemotherapy-a-retrospective-study-of-192-cases-from-national-cancer-center-in-china
#4
Yuelu Zhu, Yongkun Sun, Shangying Hu, Yong Jiang, Jiangying Yue, Xuemin Xue, Lin Yang, Liyan Xue
BACKGROUND: Neoadjuvant chemotherapy has been increasingly practiced on gastric cancer (GC), and histological evaluation to predict outcome is urgent in clinical practice. There are five classic tumor regression grading (TRG) systems, including Mandard-TRG system, the Japanese Gastric Cancer Association (JGCA)-TRG system, College of American Pathologists (CAP)-TRG system, China-TRG system and Becker-TRG system. METHODS: Totally, 192 patients of gastric adenocarcinoma (including adenocarcinoma of the esophagogastric junction) treated by neoadjuvant chemotherapy and surgery were evaluated using the above five TRG systems...
March 14, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28279470/novel-targeted-therapies-for-esophagogastric-cancer
#5
REVIEW
Steven B Maron, Daniel V T Catenacci
Gastroesophageal cancer (GEC) remains a major cause of cancer-related mortality worldwide. Although the incidence of distal gastric adenocarcinoma (GC) is declining in the United States, proximal esophagogastric junction adenocarcinoma (EGJ) is increasing in incidence. GEC, including GC and EGJ, is treated uniformly in the metastatic setting. Overall survival in the metastatic setting remains poor. Molecular characterization of GEC has identified mutations and copy number variations, along with other oncogenes, biomarkers, and immuno-oncologic checkpoints that may serve as actionable therapeutic targets...
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28251360/role-of-3d-in-minimally-invasive-esophagectomy
#6
Alexandros Charalabopoulos, Bruno Lorenzi, Ali Kordzadeh, Cheuk-Bong Tang, Sritharan Kadirkamanathan, Naga Venkatesh Jayanthi
PURPOSE: Two-stage minimally invasive esophagectomy (MIE) has gained popularity in the surgical treatment of esophageal cancer. MIE's limitation is embedded in the construction of intrathoracic anastomosis. Various anastomotic techniques have been reported; however, the mechanical one remains the most commonly adopted. This pilot study aims to describe an efficient, safe, and reproducible way of performing a hand-sewn intrathoracic esophagogastric anastomosis in conjunction with short-term results using 2D and 3D thoracoscopic approaches...
March 1, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28249280/perioperative-chemotherapy-in-elderly-patients-with-locally-advanced-adenocarcinoma-of-the-stomach-and-the-esophagogastric-junction-a-retrospective-cohort-analysis-of-toxicity-and-efficacy-at-the-national-center-for-tumor-diseases-heidelberg
#7
Georg Martin Haag, Anne Byl, Dirk Jäger, Anne Katrin Berger
OBJECTIVE: Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxic but active regimens. METHODS: Using a prospectively generated database, we analyzed 63 patients aged ≥70 years undergoing perioperative chemotherapy for locally advanced esophagogastric cancer...
March 2, 2017: Oncology
https://www.readbyqxmd.com/read/28207537/lymph-node-dissection-for-siewert-ii-esophagogastric-junction-adenocarcinoma-a-retrospective-study-of-3-surgical-procedures
#8
Xiao-Feng Duan, Jie Yue, Peng Tang, Xiao-Bin Shang, Hong-Jing Jiang, Zhen-Tao Yu
The present study was aimed to investigate the application of right thansthoracic Ivor-Lewis (IL), left transthoracic (LTT), and left thoracoabdominal (LTA) approach in Siewert type II adenocarcinoma of esophagogastric junction (AEG).The data of 196 patients with Siewert type II AEG received surgical resection in our cancer center between January 2014 and April 2016 was retrospectively analyzed. Finally, 136 patients met the inclusion criteria were enrolled in the study and divided into the IL (47 cases), LTT (51 cases), and LTA group (38 cases)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28174399/-treatment-strategy-for-esophagogastric-junction-carcinoma-highly-controversial-topic-in-the-upper-gastrointestinal-malignancy
#9
Hiroharu Yamashita, Yasuyuki Seto
Among the 3 subtypes of adenocarcinoma of the esophagogastric junction (AEG), Siewert type I is basically consistent with esophageal adenocarcinoma arising from the Barrett epithelium( Barrett's adenocarcinoma), and type III is gastric carcinoma with esophageal invasion over the esophagogastric junction(EGJ). It is generally endorsed that type I is treated as an esophageal carcinoma, and type III as a gastric carcinoma. Siewert type II carcinoma, located just at the borderline between the esophagus and the stomach, has been a highly controversial topic regarding surgical approach, extent of esophagogastric resection and lymphadenectomy, type of reconstruction, and even the staging system...
January 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28173664/-pathology-consensus-of-gastroesophageal-reflux-disease-barrett-s-esophagus-and-adenocarcinoma-of-esophagogastric-junction
#10
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28168205/role-of-nampt-and-visceral-adiposity-in-esophagogastric-junction-adenocarcinoma
#11
Haijun Li, E Bai, Yong Zhang, Zhuoqi Jia, Shicai He, Junke Fu
Nampt including eNampt and iNampt may contribute to mediating obesity-associated cancers. This study investigated the role of Nampt in esophagogastric junction adenocarcinoma (EGA), a cancer strongly correlated with obesity. Visceral adiposity was defined by waist circumference or VFA. eNampt in sera were measured by enzyme-linked immunosorbent assay. iNampt expression in EGA was determined by PCR, western blot, and immunohistochemistry. Sera eNampt were significantly elevated in these overweight and obese patients, especially for viscerally obese patients, and positively correlated with BMI, waist circumference, VFA, and also primary tumor, regional lymph nodes, and TNM stage (P < 0...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28133262/-a-case-of-recurrent-esophagogastric-junction-cancer-responding-to-trastuzumab
#12
Yuta Kobayashi, Motohiro Hirao, Kazuyoshi Yamamoto, Kazuhiro Nishikawa, Sakae Maeda, Mamoru Uemura, Masakazu Miyake, Naoki Hama, Atsushi Miyamoto, Michihiko Miyazaki, Masataka Ikeda, Shoji Nakamori, Mitsugu Sekimoto, Kiyoshi Mori, Masayuki Mano
We report a case of recurrent esophagogastric junction cancer successfully treated with chemotherapy including trastuzumab. A 66-year-old man reporting black stool was examined, and through upper gastrointestinal endoscopy was found to have a tumor at the esophagogastric junction. Video-assisted thoracoscopic surgery of the esophagus with 3-field lymph node dissection was performed. The final diagnosis was adenocarcinoma(tub1-pap-muc), pT3N3M0, pStage III C. The tumor was at the squamo-columnar junction and classified as Siewert type II ...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133205/-a-case-of-successful-multidisciplinary-therapy-for-advanced-esophagogastric-junction-cancer-with-multiple-lymph-node-metastase
#13
Kohei Murakami, Shigeyuki Tamura, Atsushi Takeno, Tomo Ishida, Ryuichi Kuwahara, Yasuki Akiyama, Takuya Sakamoto, Junichi Inatome, Atsushi Naito, Yoshiteru Katsura, Yoshiaki Ohmura, Yoshinori Kagawa, Chiyomi Egawa, Yutaka Takeda, Takeshi Kato
A 64-year-old man reporting dysphagia was examined. Upper gastrointestinal endoscopy showed a type 3 cancer at the esophagogastric junction. Enhanced CT scan showed several swollen mediastinal and abdominal lymph nodes. We diagnosed the patient with advanced adenocarcinoma of the esophagogastric junction with multiple lymph node metastases(Siewert type II , cT3N2M1[LYM], Stage IV ). After 5 courses of chemotherapy(S-1 plus cisplatin), a significant reduction was observed in the size of the tumor and lymph nodes...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28100248/mediastinal-lymph-node-dissection-and-distal-esophagectomy-is-not-essential-in-early-esophagogastric-junction-adenocarcinoma
#14
In-Seob Lee, Ji-Yong Ahn, Jeong-Hwan Yook, Byung-Sik Kim
BACKGROUND: Optimal extent of surgery remains controversial in types 2 and 3 adenocarcinoma of esophagogastric junction (AEG). We aimed to determine whether the extended procedure including mediastinal lymphadenectomy is essential in all patients with AEG by comparing prognosis and recurrence of proximal gastric adenocarcinoma based on total gastrectomy with intra-abdominal lymphadenectomy. METHODS: The clinicopathologic characteristics of 672 patients (type 2: 90, type 3: 211, upper third of the stomach: 371 cases) who underwent curative total gastrectomy with lymphadenectomy between 2003 and 2009 were reviewed...
January 18, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28078108/egfr-family-and-cmet-expression-profiles-and-prognostic-significance-in-esophagogastric-adenocarcinoma
#15
Ellie Chan, Ahmad Alkhasawneh, Lizette Vila Duckworth, Tabish Aijaz, Tania Zuluaga Toro, Xiaomin Lu, Steven J Hughes, Amy Collinsworth, Thomas J George
BACKGROUND: Targeted therapy with anti-human epidermal growth factor receptor-2 (HER2) monoclonal antibody in patients with HER2 overexpressed esophagogastric adenocarcinoma (EGA) improves survival; however, the effect is transient due to the development of resistance. Some studies suggest that cMet overexpression provides cross talk for epidermal growth factor receptor (EGFR) and HER2 inhibition. We sought to characterize the expression profile of the EGFR family and cMet receptors in untreated, resected EGA...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28054539/erratum-the-postoperative-complication-for-adenocarcinoma-of-esophagogastric-junction
#16
(no author information available yet)
[This corrects the article DOI: 10.4103/0973-1482.163867.].
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28039533/western-strategy-for-egj-carcinoma
#17
REVIEW
Simone Giacopuzzi, Maria Bencivenga, Jacopo Weindelmayer, Giuseppe Verlato, Giovanni de Manzoni
In this paper, the epidemiological and clinicobiological behavior of esophagogastric junction (EGJ) adenocarcinoma in the West is compared and contrasted to that in the East, and an overview is provided of current therapeutic strategies employed for this type of tumor in Western countries. It is well known that multimodal treatment is the therapeutic standard in locally advanced EGJ adenocarcinoma, but whether neoadjuvant/perioperative chemotherapy (CT) or neoadjuvant chemoradiotherapy (CRT) is the optimal approach is still debated...
March 2017: Gastric Cancer
https://www.readbyqxmd.com/read/27995482/comparison-of-long-term-outcomes-of-endoscopic-submucosal-dissection-and-surgery-for-esophagogastric-junction-adenocarcinoma
#18
Eun Jeong Gong, Do Hoon Kim, Ji Yong Ahn, Kee Wook Jung, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Hee Sung Kim, In-Seob Lee, Beom Su Kim, Moon-Won Yoo, Sung Tae Oh, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Endoscopic submucosal dissection (ESD) has become accepted as the standard treatment for early gastric cancer. However, comparative outcomes of ESD and surgery have not been evaluated for adenocarcinoma in the esophagogastric junction (EGJ). We investigated the long-term outcomes of ESD compared with those of surgery for adenocarcinoma in the EGJ. METHODS: Patients who underwent ESD or surgery for Siewert type II adenocarcinoma between 2005 and 2010 and who met the absolute and expanded criteria for endoscopic resection were eligible...
March 2017: Gastric Cancer
https://www.readbyqxmd.com/read/27981384/laparoscopic-assisted-versus-open-total-gastrectomy-for-siewert-type-ii-and-iii-esophagogastric-junction-carcinoma-a-propensity-score-matched-case-control-study
#19
Chang-Ming Huang, Chen-Bin Lv, Jian-Xian Lin, Qi-Yue Chen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu
BACKGROUND: Few studies have evaluated the outcomes of laparoscopic-assisted total gastrectomy (LATG) for Siewert type II and III adenocarcinoma of the esophagogastric junction (AEG). Thus, aim of this study was to investigate the surgical outcomes of LATG for Siewert type II and III AEG. METHODS: Clinical data for 700 Siewert type II and III AEG patients were analyzed retrospectively. The short- and long-term outcomes were compared between the matched groups using a propensity score matching method...
December 15, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27938582/-short-term-outcomes-of-minimally-invasive-sweet-esophagectomy-for-siewert-type-%C3%A2-esophagogastric-junction-adenocarcinoma
#20
C Q Liu, M R Xie, M F Guo, X H Sun, H R Wu, X X Sun, M Q Xu
Objective: To describe the technique for minimally invasive Sweet esophagectomy and to evaluate the feasibility, safety and the short-term clinical outcomes of this approach in the treatment of Siewert type Ⅱ esophagogastric junction adenocarcinoma. Methods: The clinical data of 122 patients with Siewert type Ⅱ esophagogastric junction adenocarcinoma who received Sweet esophagectomy between October 2013 and June 2015 in Department of Thoracic Surgery, Anhui Provincial Hospital Affiliated with Anhui Medical University was analyzed retrospectively...
June 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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