Yudun Qu, Shibo Chen, Mengling Han, Ziqi Gu, Yujie Zhang, Tianxiang Fan, Muhui Zeng, Guangfeng Ruan, Peihua Cao, Qian Yang, Changhai Ding, Yan Zhang, Zhaohua Zhu
OBJECTIVE: To investigate the causal relationship between low bone mineral density (BMD) and osteoarthritis (OA) using Mendelian randomization (MR) design. METHODS: Two-sample bi-directional MR analyses were performed using summary-level information on OA traits from UK Biobank and arcOGEN. Sensitivity analyses including MR-Egger, simple median, weighted median, MR pleiotropy residual sum, and outlier approaches were utilized in conjunction with inverse variance weighting (IVW)...
December 13, 2023: Arthritis Research & Therapy