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Paediatric respiratory infection

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https://www.readbyqxmd.com/read/28107788/the-indications-and-role-of-paediatric-bronchoscopy-in-a-developing-country-with-high-prevalence-of-pulmonary-tuberculosis-and-hiv
#1
Irwin Webster, Pierre Goussard, Robert Gie, Jacques Janson, Gawie Rossouw
BACKGROUND: Bronchoscopy, an important investigation for the diagnosis and management of respiratory diseases, is widely used in high income countries. There is limited information on value of paediatric bronchoscopy in low and middle income countries (LMIC). AIMS AND OBJECTIVES: Aim was to describe the indications, findings and complications of bronchoscopy in a middle income country with a high prevalence of tuberculosis and HIV. METHODOLOGY: A retrospective analysis of a database over a 3...
January 20, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28105526/first-versus-second-year-respiratory-syncytial-virus-prophylaxis-in-chronic-lung-disease-2005-2015
#2
Daniel Y Wang, Abby Li, Bosco Paes, Ian Mitchell, Krista L Lanctôt
: Children aged <2 years with chronic lung disease (CLD) have a 10-fold higher risk for respiratory syncytial virus-positive hospitalization (RSVH) compared to healthy term infants. Based on the updated position statements, we compared respiratory-related illness hospitalization (RIH) and RSVH risks in CLD children who received palivizumab during the first year (FY) versus second year (SY) of life in the Canadian Registry of Palivizumab (CARESS). Demographic data were collected at enrolment and RIH events recorded monthly from 2005 to 2015...
January 20, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28097718/a-prospective-study-of-the-use-of-antibiotics-in-the-emergency-department-of-a-chinese-university-hospital
#3
Linan Zeng, Die Hu, Imti Choonara, Dezhi Mu, Lingli Zhang, Xihong Li, Zuojie Zhang, Zhiqiang Hu, Shuyan Quan
BACKGROUND: Antibiotics are one of the most widely misused group of medicines. The aim of this study was to investigate the use of antibiotics in one of the paediatric emergency departments in China. METHODS: We performed a prospective, cross-sectional study of antibiotic use in the paediatric emergency room of West China Second University Hospital. A total of 500 consecutive patients from March 25 to April 3 2013 were included. Clinical details of the patients were also collected in order to analyse antibiotic use...
February 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28097716/parental-knowledge-of-antibiotic-use-in-children-with-respiratory-infections-a-systematic-review
#4
REVIEW
Lourdes Cantarero-Arévalo, Mia Pavelics Hallas, Susanne Kaae
OBJECTIVE: Antimicrobial resistance (AMR) is an increasing global problem. AMR threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. The misuse and overuse of antibiotics (AB) is the major contributor to the emergence of resistant bacteria in humans. To present and describe characteristics in parents' knowledge about when and how to use AB for an upper respiratory tract infection (URTI), their attitudes towards doctors and AB use in general, and their behaviour when their child suffers from an URTI...
February 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28096254/factors-predicting-antibiotic-prescription-and-referral-to-hospital-for-children-with-respiratory-symptoms-secondary-analysis-of-a-randomised-controlled-study-at-out-of-hours-services-in-primary-care
#5
Ingrid Keilegavlen Rebnord, Hogne Sandvik, Anders Batman Mjelle, Steinar Hunskaar
OBJECTIVES: Acute respiratory infections and fever among children are highly prevalent in primary care. It is challenging to distinguish between viral and bacterial infections. Norway has a relatively low prescription rate of antibiotics, but it is still regarded as too high as the antimicrobial resistance is increasing. The aim of the study was to identify predictors for prescribing antibiotics or referral to hospital among children. DESIGN: Secondary analysis of a randomised controlled study...
January 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28095399/evaluation-of-treatment-related-mortality-among-paediatric-cancer-deaths-a-population-based-analysis
#6
Jason D Pole, Paul Gibson, Marie-Chantal Ethier, Tanya Lazor, Donna L Johnston, Carol Portwine, Mariana Silva, Sarah Alexander, Lillian Sung
BACKGROUND: Objectives were to describe the proportion of deaths due to treatment-related mortality (TRM) and to identify risk factors and probable causes of TRM among paediatric cancer deaths in a population-based cohort. METHODS: We included children with cancer ⩽18 years diagnosed and treated in Ontario who died between January 2003 and December 2012. Deaths were identified using a provincial registry, the Pediatric Oncology Group of Ontario Networked Information System...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28089444/health-care-associated-infections-in-neonates-children-and-adolescents-an-analysis-of-paediatric-data-from-the-european-centre-for-disease-prevention-and-control-point-prevalence-survey
#7
Walter Zingg, Susan Hopkins, Angèle Gayet-Ageron, Alison Holmes, Mike Sharland, Carl Suetens
BACKGROUND: In 2011-12, the European Centre for Disease Prevention and Control (ECDC) held the first Europe-wide point-prevalence survey of health-care-associated infections in acute care hospitals. We analysed paediatric data from this survey, aiming to calculate the prevalence and type of health-care-associated infections in children and adolescents in Europe and to determine risk factors for infection in this population. METHODS: Point-prevalence surveys took place from May, 2011, to November, 2012, in 1149 hospitals in EU Member States, Iceland, Norway, and Croatia...
January 12, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28064293/epidemiological-and-clinical-features-of-enteroviral-acute-lower-respiratory-tract-infections-in-hospitalized-paediatric-patients-in-a-malaysian-tertiary-center
#8
J W Y Tan, R Nuryasmin, Y Apandi, V Nethiya, H Hussin, A L Zuraidah
BACKGROUND: Human enteroviruses (HEVs) have been recognized to cause a significant number of respiratory tract infections in many regions. Previous studies conducted to analyse enteroviral respiratory tract infections focused on outbreaks. Data in the Southeast Asian region is still rather limited to date. OBJECTIVES: We conducted a prospective analysis to understand the epidemiological characteristics of enteroviral lower respiratory tract infections (LRTIs) among paediatric patients admitted to Hospital Ampang, a tertiary hospital in Malaysia...
October 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28063821/-influence-of-postcode-on-paediatric-admissions-in-seville
#9
Sebastián Tornero Patricio, Liliana Charris-Castro, Mercedes Granero Asencio, Antonio Daponte Codina
INTRODUCTION: The postcode (where the home is situated) is an indicator of socioeconomic status and is associated with morbidity, mortality, and the use of health services. The aim of this study was to analyse its effects on paediatric admissions and to determine the rates of the most common causes of paediatric admissions in Seville. MATHERIAL AND METHODS: An observational cross-sectional study with two analysis units: under 15 year-old "admissions" in public hospitals in Seville (n=2,660) and "city districts" of Seville (n=11)...
January 4, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28062684/sale-of-antibiotics-without-a-prescription-at-community-pharmacies-in-urban-china-a-multicentre-cross-sectional-survey
#10
Jie Chang, Dan Ye, Bing Lv, Minghuan Jiang, Shan Zhu, Kangkang Yan, Yun Tian, Yu Fang
OBJECTIVES: To quantify sales of antibiotics without a medical prescription and to assess the quality of pharmacy services in relation to the antibiotics sold in community pharmacies in urban China. METHODS: A multicentre cross-sectional survey of community pharmacies was undertaken in 2015 using the simulated client method. Two clinical case scenarios (paediatric diarrhoea and adult acute upper respiratory infection) were presented at systematically sampled community pharmacies in Eastern (Nanjing), Central (Changsha) and Western China (Xi'an)...
January 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28058755/characteristics-of-bordetella-pertussis-infection-among-infantsand-children-admitted-to-paediatric-intensive-care-units-in-greece-a-multicentre-11-year-study
#11
Maria S Kazantzi, Anargyroula Prezerakou, Serafeia N Kalamitsou, Stavroula Ilia, Panagiotis K Kalabalikis, John Papadatos, Maria M Sdougka, George Briassoulis, Maria N Tsolia
AIM: To describe children with pertussis who required intensive care. METHODS: This is a retrospective analysis of pertussis admissions to all (six) national intensive care units in Greece from 2003 to 2013. RESULTS: A total of 31 children were included, 28 of whom were younger than 12 months old. Cough was the most prominent symptom, being present in 27 of 31 (87%) patients, and on admission, only 7 (22.6%) satisfied the case definition...
January 6, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28050458/congenital-cystic-adenomatoid-malformation-a-tertiary-care-hospital-experience
#12
Asmita Anilkumar Mehta, Naveen Viswanathan, Anil Kumar Vasudevan, Roopa Paulose, Mohan Abraham
INTRODUCTION: Congenital Cystic Adenomatoid Malformation (CCAM) is an uncommon developmental deformity affecting the terminal respiratory structures. It is characterized by broncho pulmonary foregut malformations. The reason behind it is an arrest in lung development between 4(th) and 7(th) week of fetal life. AIM: The present study was conducted to assess the clinical and radiological profile and also to study the role of surgical intervention in patients with CCAM...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28030608/predicting-hospitalised-paediatric-pneumonia-mortality-risk-an-external-validation-of-risc-and-mrisc-and-local-tool-development-risc-malawi-from-malawi
#13
Shubhada Hooli, Tim Colbourn, Norman Lufesi, Anthony Costello, Bejoy Nambiar, Satid Thammasitboon, Charles Makwenda, Charles Mwansambo, Eric D McCollum, Carina King
BACKGROUND: Pneumonia is the leading infectious cause of under-5 mortality in sub-Saharan Africa. Clinical prediction tools may aide case classification, triage, and allocation of hospital resources. We performed an external validation of two published prediction tools and compared this to a locally developed tool to identify children admitted with pneumonia at increased risk for in-hospital mortality in Malawi. METHODS: We retrospectively analyzed the performance of the Respiratory Index of Severity in Children (RISC) and modified RISC (mRISC) scores in a child pneumonia dataset prospectively collected during routine care at seven hospitals in Malawi between 2011-2014...
2016: PloS One
https://www.readbyqxmd.com/read/28005688/respiratory-syncytial-virus-infection-associated-hospitalization-rates-in-infants-and-children-with-cystic-fibrosis
#14
Jakob Metz, Ernst Eber, Bernhard Resch
BACKGROUND: Infections with respiratory syncytial virus (RSV) are the leading cause for hospital admissions in infants and young children. The incidence of RSV-related hospitalizations in patients with cystic fibrosis (CF) is unclear. To date no effective treatment for RSV infections is available. Thus, prophylaxis with the monoclonal antibody palivizumab is an important option. METHODS: In a retrospective, single-center study at the Department of Paediatrics and Adolescent Medicine of the Medical University Graz, Austria, we analyzed all CF patients born between 1995 and 2012, who were admitted for respiratory problems between 1995 and 2014...
December 21, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28004493/economic-evaluation-of-nasogastric-versus-intravenous-hydration-in-infants-with-bronchiolitis
#15
Ed Oakley, Rob Carter, Bridie Murphy, Meredith Borland, Jocelyn Neutze, Jason Acworth, David Krieser, Stuart Dalziel, Andrew Davidson, Susan Donath, Kim Jachno, Mike South, Franz E Babl
OBJECTIVE: Bronchiolitis is the most common lower respiratory tract infection in infants and the leading cause of hospitalisation. We aimed to assess whether intravenous hydration (IVH) was more cost-effective than nasogastric hydration (NGH) as a planned secondary economic analysis of a randomised trial involving 759 infants (aged 2-12 months) admitted to hospital with a clinical diagnosis of bronchiolitis and requiring non-oral hydration. No Australian cost data exist to aid clinicians in decision-making around interventions in bronchiolitis...
December 22, 2016: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/27957481/respiratory-infection-rates-differ-between-geographically-distant-paediatric-cystic-fibrosis-cohorts
#16
Kathryn A Ramsey, Emily Hart, Lidija Turkovic, Marc Padros-Goossens, Stephen M Stick, Sarath C Ranganathan
Respiratory infections are a major cause of pulmonary decline in children with cystic fibrosis (CF). We compared the prevalence of infection in early life at geographically distant CF treatment centres participating in the same surveillance programme in Australia. Lower airway microbiology, inflammation and structural lung disease at annual review were evaluated for 260 children 0-8 years old with CF at 1032 visits to CF treatment centres in Melbourne or Perth. Melbourne patients were more likely to be culture-positive for common respiratory pathogens at all age groups (odds ratio (OR) 1...
July 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27865727/-epidemiology-of-patients-hospitalised-due-to-bronchiolitis-in-the-south-of-europe-analysis-of-the-epidemics-2010-2015
#17
José Miguel Ramos-Fernández, Eva Pedrero-Segura, Mario Gutiérrez-Bedmar, Beatriz Delgado-Martín, Ana María Cordón-Martínez, David Moreno-Pérez, Antonio Urda-Cardona
INTRODUCTION: The renewal of clinical practice guidelines on acute bronchiolitis (AB) requires the re-assessment of the consequences of their implementation. An update is presented on the main clinical and epidemiological variables in patients hospitalised due to AB in Southern Europe and an analysis made of the causes associated with longer hospital stay. PATIENTS AND METHOD: A retrospective study was conducted on patients admitted to hospital due to AB during 5 epidemics (2010-2015), with an analysis of the major clinical and epidemiological variables...
November 16, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27836955/ifn-%C3%AE-ifn-%C3%AE-responses-to-respiratory-viruses-in-paediatric-asthma
#18
Annika Bergauer, Nina Sopel, Bettina Kroß, Tytti Vuorinen, Paraskevi Xepapadaki, Scott T Weiss, Ashley Blau, Himanshu Sharma, Cornelia Kraus, Rebekka Springel, Manfred Rauh, Susanne Mittler, Anna Graser, Theodor Zimmermann, Volker O Melichar, Alexander Kiefer, Marek L Kowalski, Anna Sobanska, Tuomas Jartti, Heikki Lukkarinen, Nikolaos G Papadopoulos, Susetta Finotto
We analysed the influence of rhinovirus (RV) in nasopharyngeal fluid (NPF) on type I and III interferon (IFN) responses (e.g. IFN-α and IFN -: λ) and their signal transduction, at baseline and during disease exacerbation, in cohorts of pre-school children with and without asthma.At the time of recruitment into the Europe-wide study PreDicta, and during symptoms, NPF was collected and the local RV colonisation was analysed. Peripheral blood mononuclear cells (PBMCs) were challenged in vitro with RV or not...
November 11, 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27812804/paediatric-antibiotic-prescriptions-in-primary-care-in-the-alpes-maritimes-area-of-southeastern-france-between-2008-and-2013
#19
P Touboul-Lundgren, P Bruno, L Bailly, B Dunais, C Pradier
France has remained among the top five European countries for ambulatory antibiotic consumption since such monitoring began in 1998. Young children are major antibiotic consumers, in spite of the viral origin of most infections in this population. Recommendations were updated in 2011 to limit prescriptions. In order to assess their impact, diagnoses and prescriptions were compared in a population of children attending daycare centres in southeastern France in 2008 and 2012. Trends in the reimbursement of paediatric antibiotic prescriptions by the national health insurance (NHI) for the whole area were also studied...
November 3, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27774707/bocavirus-infection-following-paediatric-liver-transplantation
#20
M Y Tan, L N Tan, M M Aw, S H Quak, S V Karthik
HBoV is an emergent virus, which is frequently detected as a co-infective agent. However, it can cause disease on its own. It is associated with respiratory and diarrhoeal illness in children and adults, whether immunocompetent or immunocompromised. We report HBoV infection in a child post-liver transplantation, who presented with persistent fever and mild tachypnea, 3 weeks after a successful transplant. She recovered spontaneously with no graft dysfunction.
October 23, 2016: Pediatric Transplantation
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