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https://www.readbyqxmd.com/read/28805702/study-on-the-status-of-health-service-utilization-among-caregivers-of-left-behind-children-in-poor-rural-areas-of-hunan-province-a-baseline-survey
#1
Meimei Ji, Yefu Zhang, Jiaojiao Zou, Tong Yuan, Amber Tang, Jing Deng, Lina Yang, Mingzhi Li, Jihua Chen, Hong Qin, Qian Lin
BACKGROUND: The caregivers of left-behind children (CLBC) in China's poor, rural areas are mostly elderly and women. Their health status and access to health services have not been previously characterized. This study aims to explore the status of CLBC in terms of their health service utilization and to provide a scientific basis for guiding effective implementation of health policy in rural Hunan. METHODS: Random cluster sampling was used to survey CLBC in two rural counties...
August 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28805310/use-of-direct-oral-anticoagulants-for-stroke-prevention-in-elderly-patients-with-nonvalvular-atrial-fibrillation
#2
Lynn B Oertel, Annemarie E Fogerty
BACKGROUND AND PURPOSE: Four direct oral anticoagulants (DOACs) are available for the prevention of stroke in nonvalvular atrial fibrillation (NVAF): dabigatran (a direct thrombin inhibitor); and rivaroxaban, apixaban, and edoxaban (factor Xa inhibitors). This article summarizes the safety and efficacy of DOACs for the prevention of stroke in elderly NVAF patients. METHODS: PubMed was searched to identify published results of randomized, controlled trials evaluating DOACs for stroke prevention in elderly NVAF patients...
August 14, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28802598/effect-of-parecoxib-sodium-pretreatment-combined-with-dexmedetomidine-on-early-postoperative-cognitive-dysfunction-in-elderly-patients-after-shoulder-arthroscopy-a-randomized-double-blinded-controlled-trial
#3
Jian Lu, Gang Chen, Hongmei Zhou, Qinghe Zhou, Zhipeng Zhu, Cheng Wu
STUDY OBJECTIVE: To evaluate effect of parecoxib sodium pretreatment combined with dexmedetomidine on early postoperative cognitive dysfunction in elderly patients after shoulder arthroscopy. DESIGN: Randomized, double-blind study. SETTING: University-affiliated teaching hospital. PATIENTS: One hundred and fifty-two elderly patients scheduled for shoulder arthroscopy. INTERVENTIONS: At 15min before the induction of anesthesia, 152 patients received intravenously parecoxib sodium 40mg and dexmedetomidine at a dose of 0...
September 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28801938/factors-in-variability-of-serial-gabapentin-concentrations-in-elderly-patients-with-epilepsy
#4
Jeannine M Conway, Lynn E Eberly, Joseph F Collins, Flavia M Macias, R Eugene Ramsay, Ilo E Leppik, Angela K Birnbaum
OBJECTIVES: To characterize and quantify the variability of serial gabapentin concentrations in elderly patients with epilepsy. METHODS: This study included 83 patients (age ≥60 years) from an 18-center, randomized, double-blind, double dummy, parallel study from the Veterans Affairs Cooperative 428 Study. All patients were taking 1500 mg/day of gabapentin. Within-person coefficient of variation (CV) in gabapentin concentrations, measured weekly to bimonthly for up to 52 weeks, then quarterly, was computed...
August 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28800755/the-influence-of-3%C3%A2-months-of-physical-exercises-and-verbal-stimulation-on-functional-efficiency-and-use-of-free-time-in-an-older-population-under-institutional-care-study-protocol-for-a-randomized-controlled-trial
#5
Agnieszka Wiśniowska-Szurlej, Agnieszka Ćwirlej-Sozańska, Anna Wilmowska-Pietruszyńska, Natalia Milewska, Bernard Sozański
BACKGROUND: In recent years, there has been a significant change in the demographics of developed countries, including an increase in the number of older people. This aging population and the associated need for medical care and assistance places great strain on health care systems worldwide. In older populations, improved knowledge and understanding of the relationship between moderate exercise and health might result in greater motivation to engage in such activity; thus improving the overall health of this population...
August 11, 2017: Trials
https://www.readbyqxmd.com/read/28800722/randomized-comparison-of-sevoflurane-versus-propofol-remifentanil-on-the-cardioprotective-effects-in-elderly-patients-with-coronary-heart-disease
#6
Yunlong Zhang, Wendong Lin, Sheliang Shen, Hongfa Wang, Xiaona Feng, Jiehao Sun
BACKGROUND: It is skeptical about cardioprotective property of sevoflurane in patients undergoing noncardiac surgery, especially in the elderly patients with coronary heart disease. We hypothesized that long duration of sevoflurane inhalation in noncardiac surgery could ameliorate myocardial damage in such patients. METHODS: This was a randomized, prospective study. One hundred twenty-one elderly patients with coronary heart disease were randomly allocated into two groups...
August 11, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28799226/educational-intervention-on-medication-reviews-aiming-to-reduce-acute-healthcare-consumption-in-elderly-patients-with-potentially-inappropriate-medicines-a-pragmatic-open-label-cluster-randomized-controlled-trial-in-primary-care
#7
K Schmidt-Mende, M Andersen, B Wettermark, J Hasselström
PURPOSE: Potentially inappropriate medicines (PIMs) may cause 10% of unplanned admissions in elderly people. We performed an educational intervention in primary care to reduce acute health care consumption and PIMs through the promotion of medication reviews (MRs) in elderly patients. METHODS: This cluster-randomized controlled trial was conducted in the context of an official campaign promoting rational drug use in elderly people. Sixty-nine primary health care practices with 119,910 patients aged older than or equal to 65 were randomized, with 1 dropout in the intervention group...
August 11, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28799216/device-measured-physical-activity-as-a-predictor-of-disability-in-mobility-limited-older-adults
#8
Robert T Mankowski, Stephen D Anton, Robert Axtell, Shyh-Huei Chen, Roger A Fielding, Nancy W Glynn, Fang-Chi Hsu, Abby C King, Andrew S Layne, Christiaan Leeuwenburgh, Todd M Manini, Anthony P Marsh, Marco Pahor, Catrine Tudor-Locke, David E Conroy, Thomas W Buford
OBJECTIVES: To examine associations between objectively measured physical activity (PA) and incidence of major mobility disability (MMD) and persistent MMD (PMMD) in older adults in the Lifestyle Interventions and Independence for Elders (LIFE) Study. DESIGN: Prospective cohort of individuals aged 65 and older undergoing structured PA intervention or health education. SETTING: The LIFE Study was a multicenter (eight sites) randomized controlled trial designed to compare the efficacy of a long-term structured PA intervention with that of a health education (HE) program in reducing the incidence of MMD in mobility-limited older adults...
August 11, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28798682/a-novel-virtual-reality-based-training-protocol-for-the-enhancement-of-the-mental-frame-syncing-in-individuals-with-alzheimer-s-disease-a-development-of-concept-trial
#9
Silvia Serino, Elisa Pedroli, Cosimo Tuena, Gianluca De Leo, Marco Stramba-Badiale, Karine Goulene, Noemi G Mariotti, Giuseppe Riva
A growing body of evidence suggests that people with Alzheimer's Disease (AD) show compromised spatial abilities. In addition, there exists from the earliest stages of AD a specific impairment in "mental frame syncing," which is the ability to synchronize an allocentric viewpoint-independent representation (including object-to-object information) with an egocentric one by computing the bearing of each relevant "object" in the environment in relation to the stored heading in space (i.e., information about our viewpoint contained in the allocentric viewpoint-dependent representation)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28796088/the-effect-of-citalopram-versus-a-placebo-on-central-auditory-processing-in-the-elderly
#10
Jose Fernando Polanski, Alexandra Dezani Soares, Liliane Desgualdo Pereira, Oswaldo Laercio de Mendonça Cruz
OBJECTIVE: Evaluate the effects of therapy with citalopram on the central auditory processing in the elderly measured by central auditory tests. STUDY DESIGN: Prospective, randomized, double-blind, placebo-controlled study. SETTING: Tertiary referral center. PATIENTS: Thirty-nine patients older than 60 years with normal hearing thresholds or symmetrical sensorineural hearing loss up to 70 dBHL, word-recognition score equal to or better than 70%, and diagnosed with central auditory processing disorders completed the study...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28793889/high-burden-of-hypertension-across-the-age-groups-among-residents-of-gondar-city-in-ethiopia-a-population-based-cross-sectional-study
#11
Abayneh Girma Demisse, Ermias Shenkutie Greffie, Solomon Mekonnen Abebe, Abera Balcha Bulti, Shitaye Alemu, Bewketu Abebe, Nebiyu Mesfin
BACKGROUND: According to a report on the worldwide trends in blood pressure from 1975 to 2015, mean blood pressure is increasing in low and middle income countries while it is either decreasing or stabilizing in high income countries. Few studies have been published on the prevalence of hypertension in Ethiopia demonstrating an increased trend; however, these studies had small sample size and were limited to participants older than 35 years; which left the burden among adolescents and young adults unaddressed...
August 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28791477/electroencephalographic-effect-of-age-adjusted-1-mac-desflurane-and-sevoflurane-in-young-middle-aged-and-elderly-patients
#12
Shinya Kanazawa, Yutaka Oda, Chika Maeda, Ryu Okutani
PURPOSE: We examined the hypothesis that 1 minimum alveolar concentration (MAC) of desflurane and sevoflurane provides different depth of anesthesia. METHODS: One hundred and twenty young (20-30 years), middle-aged (31-65 years), and elderly (66-80 years) patients were randomly allocated to receive either desflurane or sevoflurane (n = 20, each group). General anesthesia was induced with propofol 2 mg/kg bolus and remifentanil 0.25 µg/kg/min, which was stopped after tracheal intubation...
August 8, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28790226/effect-of-metformin-on-handgrip-strength-gait-speed-myostatin-serum-level-and-health-related-quality-of-life-a-double-blind-randomized-controlled-trial-among-non-diabetic-pre-frail-elderly-patients
#13
Purwita Wijaya Laksmi, Siti Setiati, Tirza Z Tamin, Pradana Soewondo, Wasilah Rochmah, Nafrialdi Nafrialdi, Joedo Prihartono
BACKGROUND: sarcopenia contributes to the development of frailty syndrome. Frailty syndrome is potentially improved by modifying insulin resistance, inflammation, and myostatin level. This study is aimed to investigate the effect of metformin on handgrip strength, gait speed, myostatin serum level, and health-related quality of life (HR-QoL) among non-diabetic pre-frail elderly patients. METHODS: a double blind randomized controlled trial study was conducted on non-diabetic elderly outpatients aged ≥ 60 years with pre-frail status based on phenotype and/ or index criteria (Cardiovascular Health Study and/ or Frailty Index 40 items) consecutively recruited from March 2015 to June 2016 at Cipto Mangunkusumo Hospital...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28783552/a-meta-analysis-of-randomized-trials-assessing-the-effects-of-probiotic-preparations-on-oral-candidiasis-in-the-elderly
#14
REVIEW
Ruixue Ai, Jiao Wei, Danhua Ma, Lu Jiang, Hongxia Dan, Yu Zhou, Ning Ji, Xin Zeng, Qianming Chen
OBJECTIVE: Oral candidiasis is the most common fungal infection and can be attributed in part to dysbiosis, an imbalance in the resident oral microflora. Therefore, probiotics, which counter pathogenic microorganisms through competitive, antagonistic, and immunological effects, have been used by some clinicians. To date, the effect of probiotics in preventing oral candidiasis in the elderly is controversial. A systematic review that summarizes and critically appraises the available clinical trials is therefore necessary...
April 30, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28780137/the-effect-of-drinking-water-contaminated-with-perfluoroalkyl-substances-on-a-10-year-longitudinal-trend-of-plasma-levels-in-an-elderly-uppsala-cohort
#15
Jordan Stubleski, Samira Salihovic, P Monica Lind, Lars Lind, Linda Dunder, Philip McCleaf, Karin Eurén, Lutz Ahrens, Magnus Svartengren, Bert van Bavel, Anna Kärrman
BACKGROUND: In 2012, drinking water contaminated with per- and polyfluoroalkyl substances (PFASs), foremost perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) at levels over 20ng/L and 40ng/L, respectively, was confirmed in Uppsala, Sweden. OBJECTIVES: We assessed how a longitudinally sampled cohort's temporal trend in PFAS plasma concentration was influenced by their residential location and determined the plausible association or disparity between the PFASs detected in the drinking water and the trend in the study cohort...
August 3, 2017: Environmental Research
https://www.readbyqxmd.com/read/28777862/-abcc8-gene-analysis-treatment-and-follow-up-of-an-infant-with-neonatal-diabetes-mellitus
#16
Hong Chen, Ruimin Chen, Xin Yuan, Xiaohong Yang, Shijun Chen
OBJECTIVE: To analyze the clinical characteristics of an infant with neonatal diabetes mellitus (NDM) and to sequence the ABCC8 gene of this family in order to provide a theoretical basis for the diagnosis and treatment. METHODS: The clinical data of the patient was collected, and the proband and his direct relatives within three generations were sequenced. RESULTS: The patient was 1-month-old, random blood glucose was more than 27.8 mmol/L, C-peptide was 33...
August 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28776873/the-systematic-tool-to-reduce-inappropriate-prescribing-strip-combining-implicit-and-explicit-prescribing-tools-to-improve-appropriate-prescribing
#17
A Clara Drenth-van Maanen, Anne J Leendertse, Paul A F Jansen, Wilma Knol, Carolina J P W Keijsers, Michiel C Meulendijk, Rob J van Marum
Inappropriate prescribing is a major health care issue, especially regarding older patients on polypharmacy. Multiple implicit and explicit prescribing tools have been developed to improve prescribing, but these have hardly ever been used in combination. The Systematic Tool to Reduce Inappropriate Prescribing (STRIP) combines implicit prescribing tools with the explicit Screening Tool to Alert physicians to the Right Treatment and Screening Tool of Older People's potentially inappropriate Prescriptions criteria and has shared decision-making with the patient as a critical step...
August 4, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28771081/effect-of-exercise-on-inflammatory-profile-of-older-persons-systematic-review-and-meta-analyses
#18
Renato Sobral Monteiro Junior, Paulo de Tarso Maciel-Pinheiro, Eduardo da Matta M Portugal, Luiz Felipe da Silva Figueiredo, Rodrigo Terra, Lara S F Carneiro, Vinicius Dias Rodrigues, Osvaldo José Moreira Nascimento, Andrea Camaz Deslandes, Jerson Laks
BACKGROUND: Inflammatory cytokines and acute phase proteins increase with ageing, promoting a chronic low-grade inflammation. Studies have shown a positive effect of exercise on inflammatory markers in older persons. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP) are the main biomarkers investigated. However, it is unclear if exercise could decrease all these biomarkers. PURPOSE: The aim was to analyze the effect of chronic exercise on IL-6, TNF-α and CRP levels in older persons...
August 3, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28770299/morphological-and-molecular-characterization-of-human-hamstrings-shows-that-tendon-features-are-not-influenced-by-donor-age
#19
Nicoletta Gagliano, Alessandra Menon, Federico Cabitza, Riccardo Compagnoni, Pietro Randelli
PURPOSE: Age-related modifications of tendons, such as reduced tenocyte proliferation and modified extracellular matrix (ECM) turnover, have been previously described, but results are often incomplete and discordant. The aim of this study was to investigate, using morphological and molecular methods, the effect of ageing on human tendons and tenocytes, especially focusing on the collagen turnover pathways, in order to understand how the ageing process could influence tendon biology and structure...
August 2, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28768848/predicting-major-bleeding-in-patients-with-noncardioembolic-stroke-on-antiplatelets-s2top-bleed
#20
Nina A Hilkens, Ale Algra, Hans-Christoph Diener, Johannes B Reitsma, Philip M Bath, Laszlo Csiba, Werner Hacke, L Jaap Kappelle, Peter J Koudstaal, Didier Leys, Jean-Louis Mas, Ralph L Sacco, Pierre Amarenco, Leila Sissani, Jacoba P Greving
OBJECTIVE: To develop and externally validate a prediction model for major bleeding in patients with a TIA or ischemic stroke on antiplatelet agents. METHODS: We combined individual patient data from 6 randomized clinical trials (CAPRIE, ESPS-2, MATCH, CHARISMA, ESPRIT, and PRoFESS) investigating antiplatelet therapy after TIA or ischemic stroke. Cox regression analyses stratified by trial were performed to study the association between predictors and major bleeding...
August 2, 2017: Neurology
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