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Pdx1 AND MST1

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https://www.readbyqxmd.com/read/27053234/mst1-a-promising-therapeutic-target-to-restore-functional-beta-cell-mass-in-diabetes
#1
REVIEW
Amin Ardestani, Kathrin Maedler
The loss of insulin-producing beta cells by apoptosis is a hallmark of all forms of diabetes mellitus. Strategies to prevent beta cell apoptosis and dysfunction are urgently needed to restore the insulin-producing cells and to prevent severe diabetes progression. We recently identified the serine/threonine kinase known as mammalian sterile 20-like kinase 1 (MST1) as a critical regulator of apoptotic beta cell death and dysfunction. MST1 activates several apoptotic signalling pathways, which further stimulate its own cleavage, leading to a vicious cycle of cell death...
September 2016: Diabetologia
https://www.readbyqxmd.com/read/24633305/mst1-is-a-key-regulator-of-beta-cell-apoptosis-and-dysfunction-in-diabetes
#2
Amin Ardestani, Federico Paroni, Zahra Azizi, Supreet Kaur, Vrushali Khobragade, Ting Yuan, Thomas Frogne, Wufan Tao, Jose Oberholzer, Francois Pattou, Julie Kerr Conte, Kathrin Maedler
Apoptotic cell death is a hallmark of the loss of insulin-producing beta cells in all forms of diabetes mellitus. Current treatments fail to halt the decline in functional beta cell mass, and strategies to prevent beta cell apoptosis and dysfunction are urgently needed. Here, we identified mammalian sterile 20-like kinase-1 (MST1) as a critical regulator of apoptotic beta cell death and function. Under diabetogenic conditions, MST1 was strongly activated in beta cells in human and mouse islets and specifically induced the mitochondrial-dependent pathway of apoptosis through upregulation of the BCL-2 homology-3 (BH3)-only protein BIM...
April 2014: Nature Medicine
https://www.readbyqxmd.com/read/23454691/hippo-signaling-regulates-differentiation-and-maintenance-in-the-exocrine-pancreas
#3
Tao Gao, Dawang Zhou, Chenghua Yang, Tarjinder Singh, Alfredo Penzo-Méndez, Ravikanth Maddipati, Alexandros Tzatsos, Nabeel Bardeesy, Joseph Avruch, Ben Z Stanger
BACKGROUND & AIMS: The Hippo signaling pathway is a context-dependent regulator of cell proliferation, differentiation, and apoptosis in species ranging from Drosophila to humans. In this study, we investigated the role of the core Hippo kinases-Mst1 and Mst2-in pancreatic development and homeostasis. METHODS: We used a Cre/LoxP system to create mice with pancreas-specific disruptions in Mst1 and Mst2 (Pdx1-Cre;Mst1(-/-);Mst2(fl/fl) mice), the mammalian orthologs of Drosophila Hippo...
June 2013: Gastroenterology
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