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https://www.readbyqxmd.com/read/27764933/-effectiveness-of-school-based-interventions-to-prevent-traffic-accidents-an-overview-of-secondary-literature
#1
Chiara Guerriero, Federico Verdina, Chiara Ferri, Martina Pizzaguerra, Silvia Silvestri, Nastassja Tober, Quenya Ristagno, Alessandro Costa, Michele Cerasuolo, Fabrizio Faggiano, Elias Allara
INTRODUZIONE: gli incidenti stradali sono l'ottava causa di morte al mondo e la prima tra i giovani di 15-29 anni. In Italia il Piano nazionale sicurezza stradale raccomanda l'educazione scolastica per la prevenzione degli incidenti stradali; ad oggi non esistono documenti che raccolgano evidenze di efficacia sugli interventi educativi stradali e le rapportino al contesto italiano. OBIETTIVI: riassumere e discutere ciò che è noto in letteratura riguardo agli interventi scolastici per la prevenzione degli incidenti stradali...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27764930/-national-epidemiological-surveillance-systems-of-mesothelioma-cases
#2
Pierpaolo Ferrante, Alessandra Binazzi, Claudia Branchi, Alessandro Marinaccio
: INTRODUZIONE: sebbene la relazione causale tra esposizione ad amianto e malattie neoplastiche sia ben nota, in molti Paesi il consumo del materiale è ancora rilevante e crescente. A causa della lunga latenza, nei Paesi dove è stato bandito (come in Italia) è oggi in corso un'epidemia di malattie correlate ad amianto. OBIETTIVI: descrivere i sistemi di sorveglianza dei mesoteliomi attivi nel mondo mediante un'analisi comparativa. METODI: è stata condotta una revisione bibliografica della letteratura disponibile sui sistemi di sorveglianza epidemiologica dei mesoteliomi attivi nel mondo, comparando metodi e risultati disponibili...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27727262/-somministrazione-mensile-di-aripirazolo-long-acting-come-trattamento-dei-sintomi-psicotici-nella-sindrome-di-turner-revisione-della-letteratura-e-caso-clinico
#3
Cristiano Carlone, Enrico Pompili, Cristiana Silvestrini, Giuseppe Nicolò
RIASSUNTO. La sindrome di Turner (ST) è una malattia neurogenetica caratterizzata da parziale o completa monosomia-X, di solito risultante da una non disgiunzione cromosomica sporadica. Si tratta di una delle più comuni anomalie dei cromosomi sessuali, colpendo circa 1 su 2.000 femmine nate vive. Nessuna condizione psichiatrica è stata tradizionalmente legata alla ST, ed essa non è menzionata nel DSM-IV. Nel mondo, tuttavia, sono riportati casi di ST concomitanti con patologia schizofrenica e/o con sintomatologia psicotica...
July 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27702773/clinical-outcomes-in-3343-children-and-adults-with-rheumatic-heart-disease-from-14-low-and-middle-income-countries-2-year-follow-up-of-the-global-rheumatic-heart-disease-registry-the-remedy-study
#4
Liesl Zühlke, Ganesan Karthikeyan, Mark E Engel, Sumathy Rangarajan, Pam Mackie, Blanche Cupido, Katya Mauff, Shofiqul Islam, Rezeen Daniels, Veronica Francis, Stephen Ogendo, Bernard Gitura, Charles Mondo, Emmy Okello, Peter Lwabi, Mohammed M Al-Kebsi, Christopher Hugo-Hamman, Sahar S Sheta, Abraham Haileamlak, Wandimu Daniel, Dejuma Yadeta Goshu, Senbeta G Abdissa, Araya G Desta, Bekele A Shasho, Dufera M Begna, Ahmed ElSayed, Ahmed S Ibrahim, John Musuku, Fidelia Bode-Thomas, Christopher C Yilgwan, Ganiyu A Amusa, Olukemi Ige, Basil Okeahialam, Christopher Sutton, Rajeev Misra, Azza Abul Fadl, Neil Kennedy, Albertino Damasceno, Mahmoud U Sani, Okechukwu S Ogah, Taiwo Olunuga, Huda ElHassan, Ana Olga Mocumbi, Abiodun M Adeoye, Pindile S Mntla, Dike B Ojji, Joseph Mucumbitsi, Koon Teo, Salim Yusuf, Bongani M Mayosi
BACKGROUND: -There are few contemporary data on the mortality and morbidity associated with rheumatic heart disease (RHD) or information on their predictors. We report the two year follow-up of individuals with RHD from 14 low and middle income countries in Africa and Asia. METHODS: -Between January 2010 and November 2012, we enrolled 3343 patients from 25 centers in 14 countries and followed them for two years to assess mortality, congestive heart failure (CHF), stroke or transient ischemic attack (TIA), recurrent acute rheumatic fever (ARF), and infective endocarditis (IE)...
October 4, 2016: Circulation
https://www.readbyqxmd.com/read/27696664/a-say-barber-biesecker-young-simpson-variant-of-ohdo-syndrome-with-a-kat6b-10-base-pair-palindromic-duplication-a-recurrent-mutation-causing-a-severe-phenotype-mixed-with-genitopatellar-syndrome
#5
Yo Niida, Yusuke Mitani, Mondo Kuroda, Ayano Yokoi, Hiroyasu Nakagawa, Akiko Kato
The Say-Barber-Biesecker-Young-Simpson variant of Ohdo syndrome (SBBYSS) (MIM# 603736) and genitopatellar syndrome (GPS) (MIM#606170) are allelic diseases caused by KAT6B mutation. Genotype-phenotype correlation is assumed, but a few patients manifest overlapping features of both syndromes. Here we report the case of a boy with SBBYSS. He had a KAT6B mutation previously reported in typical SBBYSS, but he also manifested severe developmental delay, as well as genital features and laryngomalacia requiring tracheostomy that conformed to GPS...
October 3, 2016: Congenital Anomalies
https://www.readbyqxmd.com/read/27664511/symptoms-and-signs-of-heart-failure-at-admission-and-discharge-and-outcomes-in-the-sub-saharan-acute-heart-failure-thesus-hf-registry
#6
Mahmoud U Sani, Gad Cotter, Beth A Davison, Bongani M Mayosi, Albertino Damasceno, Christopher Edwards, Okechukwu S Ogah, Charles Mondo, Anastase Dzudie, Dike B Ojji, Charles Kouam Kouam, Ahmed Suliman, Gerald Yonga, Sergine Abdou Ba, Fikru Maru, Bekele Alemayehu, Karen Sliwa
BACKGROUND: Symptoms and signs of heart failure (HF) are the most common reasons for admission to hospital for acute HF (AHF) and are used routinely throughout admission, to assess the severity of disease and response to therapy. METHODS AND RESULTS: The data were collected in the sub Saharan Africa survey on heart failure (THESUS-HF) study, a prospective, multicenter, observational survey of AHF, from 9 countries in sub-Saharan Africa. 1006 patients, 12 years or older, hospitalized for acute heart failure were recruited...
September 21, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27537913/cyanobacterial-neurotoxin-bmaa-and-mercury-in-sharks
#7
Neil Hammerschlag, David A Davis, Kiyo Mondo, Matthew S Seely, Susan J Murch, William Broc Glover, Timothy Divoll, David C Evers, Deborah C Mash
Sharks have greater risk for bioaccumulation of marine toxins and mercury (Hg), because they are long-lived predators. Shark fins and cartilage also contain β-N-methylamino-l-alanine (BMAA), a ubiquitous cyanobacterial toxin linked to neurodegenerative diseases. Today, a significant number of shark species have found their way onto the International Union for Conservation of Nature (IUCN) Red List of Threatened Species. Many species of large sharks are threatened with extinction due in part to the growing high demand for shark fin soup and, to a lesser extent, for shark meat and cartilage products...
2016: Toxins
https://www.readbyqxmd.com/read/27431356/global-and-regional-effects-of-potentially-modifiable-risk-factors-associated-with-acute-stroke-in-32-countries-interstroke-a-case-control-study
#8
MULTICENTER STUDY
Martin J O'Donnell, Siu Lim Chin, Sumathy Rangarajan, Denis Xavier, Lisheng Liu, Hongye Zhang, Purnima Rao-Melacini, Xiaohe Zhang, Prem Pais, Steven Agapay, Patricio Lopez-Jaramillo, Albertino Damasceno, Peter Langhorne, Matthew J McQueen, Annika Rosengren, Mahshid Dehghan, Graeme J Hankey, Antonio L Dans, Ahmed Elsayed, Alvaro Avezum, Charles Mondo, Hans-Christoph Diener, Danuta Ryglewicz, Anna Czlonkowska, Nana Pogosova, Christian Weimar, Romaina Iqbal, Rafael Diaz, Khalid Yusoff, Afzalhussein Yusufali, Aytekin Oguz, Xingyu Wang, Ernesto Penaherrera, Fernando Lanas, Okechukwu S Ogah, Adesola Ogunniyi, Helle K Iversen, German Malaga, Zvonko Rumboldt, Shahram Oveisgharan, Fawaz Al Hussain, Daliwonga Magazi, Yongchai Nilanont, John Ferguson, Guillaume Pare, Salim Yusuf
BACKGROUND: Stroke is a leading cause of death and disability, especially in low-income and middle-income countries. We sought to quantify the importance of potentially modifiable risk factors for stroke in different regions of the world, and in key populations and primary pathological subtypes of stroke. METHODS: We completed a standardised international case-control study in 32 countries in Asia, America, Europe, Australia, the Middle East, and Africa. Cases were patients with acute first stroke (within 5 days of symptom onset and 72 h of hospital admission)...
August 20, 2016: Lancet
https://www.readbyqxmd.com/read/27402359/microsporidia-intracellular-development-relies-on-myc-interaction-network-transcription-factors-in-the-host
#9
Michael R Botts, Lianne B Cohen, Christopher S Probert, Fengting Wu, Emily R Troemel
Microsporidia are ubiquitous parasites that infect a wide range of animal hosts, and these fungal-related microbes undergo their entire replicative lifecycle inside of host cells. Despite being widespread in the environment and causing medical and agricultural harm, virtually nothing is known about the host factors important to facilitate their growth and development inside of host cells. Here, we perform a genetic screen to identify host transcription factors important for development of the microsporidian pathogen Nematocida parisii inside intestinal cells of its natural host, the nematode Caenorhabditis elegans Through this screen, we identified the C...
September 8, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27358631/prevalence-types-and-factors-associated-with-echocardiographic-abnormalities-among-newly-diagnosed-diabetic-patients-at-mulago-hospital
#10
Martin Muddu, Edrisa Mutebi, Charles Mondo
BACKGROUND: The prevalence of Diabetes mellitus (DM) is on a rise in sub-Saharan Africa and will more than double by 2025. Cardiovascular disease (CVD) accounts for up to 2/3 of all deaths in the diabetic population. Of all the CVD deaths in DM, 3/4 occur in sub Saharan Africa (SSA). Non invasive identification of cardiac abnormalities, such as Left Ventricular Hypertrophy (LVH), diastolic and systolic dysfunction, is not part of diabetes complications surveillance programs in Uganda and there is limited data on this problem...
March 2016: African Health Sciences
https://www.readbyqxmd.com/read/27354820/atrial-fibrillation-among-the-black-population-in-a-ugandan-tertiary-hospital
#11
Charles Lugero, Davis Kibirige, James Kayima, Charles Kizza Mondo, Jurgen Freers
BACKGROUND: Atrial fibrillation (AF) is the most common type of sustained cardiac arrhythmia in adults, accounting for one-third of hospitalizations due to arrhythmia and related complications worldwide. Previously, rheumatic heart disease was documented as the commonest cause of AF in sub-Saharan Africa. However, due to the prevailing epidemiological transition in sub-Saharan Africa, the risk factors and ensuing complications of AF have changed and are on the increase. METHODS: This was a descriptive cross-sectional study involving 102 patients presenting with AF who were recruited from the cardiology unit of Mulago National Referral Hospital, Uganda, over 3 months...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27231381/erratum-for-walker-et-al-full-genome-of-phialocephala-scopiformis-daomc-229536-a-fungal-endophyte-of-spruce-producing-the-potent-anti-insectan-compound-rugulosin
#12
Allison K Walker, Samantha L Frasz, Keith A Seifert, J David Miller, Stephen J Mondo, Kurt LaButti, Anna Lipzen, Rhyan B Dockter, Megan C Kennedy, Igor V Grigoriev, Joseph W Spatafora
No abstract text is available yet for this article.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27206810/bi-treatment-with-hydralazine-nitrates-vs-placebo-in-africans-admitted-with-acute-heart-failure-ba-hef
#13
Karen Sliwa, Albertino Damasceno, Beth A Davison, Bongani M Mayosi, Mahmoud U Sani, Okekuchwu Ogah, Charles Mondo, Dike Ojji, Anastase Dzudie, Charles Kouam Kouam, Gerald Yonga, Serigne Abdou Ba, Elijah Ogola, Christopher Edwards, Gad Cotter
AIMS: Patients with acute heart failure in Africa are rarely being treated with a hydralazine/nitrates combination. Therefore the effect of this treatment was studied here METHODS AND RESULTS: The study was planned to enrol 500 patients during an acute heart failure (HF) admission, from nine sub-Saharan African countries. Patients were randomized in a double-blind manner to receive 50 mg hydralazine/20 mg isosorbide dinitrate (HYIS) t.i.d. or matching placebo for 24 weeks followed by open label HYIS for all patients...
May 20, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27189571/nondegenerative-evolution-in-ancient-heritable-bacterial-endosymbionts-of-fungi
#14
Stephen J Mondo, Alessandra Salvioli, Paola Bonfante, Joseph B Morton, Teresa E Pawlowska
Bacterial endosymbionts are critical to the existence of many eukaryotes. Among them, vertically transmitted endobacteria are uniquely typified by reduced genomes and molecular evolution rate acceleration relative to free-living taxa. These patterns are attributable to genetic drift-dominated degenerative processes associated with reproductive dependence on the host. The degenerative evolution scenario is well supported in endobacteria with strict vertical transmission, such as essential mutualists of insects...
September 2016: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/27102403/targeted-therapy-based-on-tumor-genomic-analyses-in-metastatic-urachal-carcinoma
#15
Kah Poh Loh, Esther Mondo, Elizabeth A Hansen, Lynn Sievert, Chunkit Fung, Deepak M Sahasrabudhe, Elizabeth Guancial
No abstract text is available yet for this article.
August 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27094625/unraveling-the-relationship-between-mortality-hyponatremia-inflammation-and-malnutrition-in-hemodialysis-patients-results-from-the-international-mondo-initiative
#16
M J E Dekker, D Marcelli, B Canaud, C J A M Konings, K M Leunissen, N W Levin, P Carioni, V Maheshwari, J G Raimann, F M van der Sande, L A Usvyat, P Kotanko, J P Kooman
BACKGROUND/OBJECTIVES: Hyponatremia is a risk factor for mortality in hemodialysis (HD) patients. It is not well known to which extent the comorbidities, malnutrition, fluid status imbalance and inflammation are related to hyponatremia and affect outcomes. SUBJECTS/METHODS: We studied 8883 patients from the European subset of the international MONitoring Dialysis Outcomes initiative. Nutritional and fluid statuses were assessed by bioimpedance spectroscopy. Fluid depletion was defined as overhydration⩽-1...
July 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27001890/mondo-complexes-regulate-tfeb-via-tor-inhibition-to-promote-longevity-in-response-to-gonadal-signals
#17
Shuhei Nakamura, Özlem Karalay, Philipp S Jäger, Makoto Horikawa, Corinna Klein, Kayo Nakamura, Christian Latza, Sven E Templer, Christoph Dieterich, Adam Antebi
Germline removal provokes longevity in several species and shifts resources towards survival and repair. Several Caenorhabditis elegans transcription factors regulate longevity arising from germline removal; yet, how they work together is unknown. Here we identify a Myc-like HLH transcription factor network comprised of Mondo/Max-like complex (MML-1/MXL-2) to be required for longevity induced by germline removal, as well as by reduced TOR, insulin/IGF signalling and mitochondrial function. Germline removal increases MML-1 nuclear accumulation and activity...
2016: Nature Communications
https://www.readbyqxmd.com/read/26985383/hemodialysis-outcomes-in-a-global-sample-of-children-and-young-adult-hemodialysis-patients-the-piccolo-mondo-cohort
#18
Maria Ferris, Keisha Gibson, Brett Plattner, Debbie S Gipson, Peter Kotanko, Daniele Marcelli, Cristina Marelli, Michael Etter, Paola Carioni, Gero von Gersdorff, Xiaoqi Xu, Jeroen P Kooman, Qingqing Xiao, Frank M van der Sande, Albert Power, Roberto Picoits-Filho, Lucimary Sylvestre, Katherine Westreich, Len Usvyat
BACKGROUND: The aim of this study was to describe the experience of pediatric and young adult hemodialysis (HD) patients from a global cohort. METHODS: The Pediatric Investigation and Close Collaborative Consortium for Ongoing Life Outcomes for MONitoring Dialysis Outcomes (PICCOLO MONDO) study provided de-identified electronic information of 3244 patients, ages 0-30 years from 2000 to 2012 in four regions: Asia, Europe, North America and South America. The study sample was categorized into pediatric (≤18 years old) and young adult (19-30 years old) groups based on the age at dialysis initiation...
April 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26958019/proportion-of-patients-in-the-uganda-rheumatic-heart-disease-registry-with-advanced-disease-requiring-urgent-surgical-interventions
#19
WanZhu Zhang, Emmy Okello, Wilson Nyakoojo, Peter Lwabi, Charles K Mondo
INTRODUCTION: Since the establishment of the Uganda Rheumatic Heart Registry, over 900 patients have been enrolled. We sought to stratify the patients in the registry according to disease severity and optimal management strategy. METHODS: We reviewed data of 618 patients who had enrolled in the Registry between March 2010 and February 2013. The 67 patients who had died were excluded leaving 551 patients who were recruited. The optimum management strategy was determined according to the 2012 European Society of Cardiology guidelines on the management of valvular heart disease...
December 2015: African Health Sciences
https://www.readbyqxmd.com/read/26950333/full-genome-of-phialocephala-scopiformis-daomc-229536-a-fungal-endophyte-of-spruce-producing-the-potent-anti-insectan-compound-rugulosin
#20
Allison K Walker, Samantha L Frasz, Keith A Seifert, J David Miller, Stephen J Mondo, Kurt LaButti, Anna Lipzen, Rhyan B Dockter, Megan C Kennedy, Igor V Grigoriev, Joseph W Spatafora
We present the full genome of Phialocephala scopiformis DAOMC 229536 (Helotiales, Ascomycota), a foliar endophyte of white spruce from eastern Quebec. DAOMC 229536 produces the anti-insectan compound rugulosin, which inhibits a devastating forestry pest, the spruce budworm. This genome will enable fungal genotyping and host-endophyte evolutionary genomics in inoculated trees.
2016: Genome Announcements
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