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https://www.readbyqxmd.com/read/29317534/linking-secondary-metabolites-to-gene-clusters-through-genome-sequencing-of-six-diverse-aspergillus-species
#1
Inge Kjærbølling, Tammi C Vesth, Jens C Frisvad, Jane L Nybo, Sebastian Theobald, Alan Kuo, Paul Bowyer, Yudai Matsuda, Stephen Mondo, Ellen K Lyhne, Martin E Kogle, Alicia Clum, Anna Lipzen, Asaf Salamov, Chew Yee Ngan, Chris Daum, Jennifer Chiniquy, Kerrie Barry, Kurt LaButti, Sajeet Haridas, Blake A Simmons, Jon K Magnuson, Uffe H Mortensen, Thomas O Larsen, Igor V Grigoriev, Scott E Baker, Mikael R Andersen
The fungal genus of Aspergillus is highly interesting, containing everything from industrial cell factories, model organisms, and human pathogens. In particular, this group has a prolific production of bioactive secondary metabolites (SMs). In this work, four diverse Aspergillus species (A. campestris, A. novofumigatus, A. ochraceoroseus, and A. steynii) have been whole-genome PacBio sequenced to provide genetic references in three Aspergillus sections. A. taichungensis and A. candidus also were sequenced for SM elucidation...
January 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29278834/sugar-sensing-by-chrebp-mondo-mlx-new-insight-into-downstream-regulatory-networks-and-integration-of-nutrient-derived-signals
#2
REVIEW
Essi Havula, Ville Hietakangas
Animals regulate their physiology with respect to nutrient status, which requires nutrient sensing pathways. Simple carbohydrates, sugars, are sensed by the basic-helix-loop-helix leucine zipper transcription factors ChREBP/Mondo, together with their heterodimerization partner Mlx, which are well-established activators of sugar-induced lipogenesis. Loss of ChREBP/Mondo-Mlx in mouse and Drosophila leads to sugar intolerance, that is, inability to survive on sugar containing diet. Recent evidence has revealed that ChREBP/Mondo-Mlx responds to sugar and fatty acid-derived metabolites through several mechanisms and cross-connects with other nutrient sensing pathways...
December 23, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29228042/risk-of-thromboembolism-in-cisplatin-versus-carboplatin-treated-patients-with-lung-cancer
#3
Eric S Kim, Andrea M Baran, Esther L Mondo, Thomas D Rodgers, Gradon C Nielsen, David W Dougherty, Kishan J Pandya, David Q Rich, Edwin van Wijngaarden
INTRODUCTION: Carboplatin is widely used to treat lung cancer in the United States as an alternative to cisplatin. Several studies have demonstrated that cisplatin-based regimen is associated with a high frequency of thromboembolic complications. However, there has been limited investigation directly comparing the risk of thromboembolic events (TEEs) between cisplatin- and carboplatin-treated patients with lung cancer. METHODS: All lung cancer patients treated with cisplatin or carboplatin at Wilmot Cancer Center, University of Rochester between 2011 and 2014 were included...
2017: PloS One
https://www.readbyqxmd.com/read/29207890/artificial-mirnas-reduce-human-mutant-huntingtin-throughout-the-striatum-in-a-transgenic-sheep-model-of-huntington-s-disease
#4
Edith Pfister, Natalie Dinardo, Erica Mondo, Florie Borel, Faith Conroy, Cara Fraser, Gwladys Gernoux, Xin Han, Danjing Hu, Emily Johnson, Lori Kennington, PengPeng Liu, Suzanne Reid, Ellen Sapp, Petr Vodicka, Tim Kuchel, A Jennifer Morton, David Howland, Richard Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, Marian DiFiglia, Neil Aronin
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a genetic expansion of the CAG repeat region in the huntingtin (HTT) gene. Studies in HD mouse models have shown that artificial miRNAs can reduce mutant HTT but evidence for their effectiveness and safety in larger animals is lacking. HD transgenic sheep express the full-length human HTT with 73 CAG repeats. We used AAV9 to unilaterally deliver to HD sheep striatum an artificial miRNA targeting exon 48 of the human HTT mRNA under control of two alternative promoters- U6 or CβA...
December 5, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29184190/bacterial-endosymbionts-influence-host-sexuality-and-reveal-reproductive-genes-of-early-divergent-fungi
#5
Stephen J Mondo, Olga A Lastovetsky, Maria L Gaspar, Nicole H Schwardt, Colin C Barber, Robert Riley, Hui Sun, Igor V Grigoriev, Teresa E Pawlowska
Many heritable mutualisms, in which beneficial symbionts are transmitted vertically between host generations, originate as antagonisms with parasite dispersal constrained by the host. Only after the parasite gains control over its transmission is the symbiosis expected to transition from antagonism to mutualism. Here, we explore this prediction in the mutualism between the fungus Rhizopus microsporus (Rm, Mucoromycotina) and a beta-proteobacterium Burkholderia, which controls host asexual reproduction. We show that reproductive addiction of Rm to endobacteria extends to mating, and is mediated by the symbiont gaining transcriptional control of the fungal ras2 gene, which encodes a GTPase central to fungal reproductive development...
November 29, 2017: Nature Communications
https://www.readbyqxmd.com/read/29154287/did-you-know-that-your-animals-have-consciousness
#6
P A Accorsi, E Mondo, M Cocchi
Consciousness is the greatest enigma in human history. For centuries scientists and researchers have tried to describe it without coming to conclusions. In the last years with the neurosciences development, consciousness has become the common goal of numerous studies. But consciousness has always been studied only in humans, but after "Cambridge Declaration on Consciousness" in 2012, even non-human animalsthey feel possessed of the consciousness. According to "theory Orch-OR" of Hameroff and Penrose we have conducted a study on Alaskan malamute and German shepherd to analysed a triplet of platelet fatty acids (linoleic acid; palmitic acid; arachidonic acid)...
November 14, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29153402/phylogenetics-and-phylogenomics-of-rust-fungi
#7
M Catherine Aime, Alistair R McTaggart, Stephen J Mondo, Sébastien Duplessis
Rust fungi (Pucciniales) are the most speciose and the most complex group of plant pathogens. Historically, rust taxonomy was largely influenced by host and phenotypic characters, which are potentially plastic. Molecular systematic studies suggest that the extant diversity of this group was largely shaped by host jumps and subsequent shifts. However, it has been challenging to reconstruct the evolutionary history for the order, especially at deeper (family-level) nodes. Phylogenomics offer a potentially powerful tool to reconstruct the Pucciniales tree of life, although researchers working at this vanguard still face unprecedented challenges working with nonculturable organisms that possess some of the largest and most repetitive genomes now known in kingdom fungi...
2017: Advances in Genetics
https://www.readbyqxmd.com/read/29139338/freeze-drying-of-silica-nanoparticles-redispersibility-toward-nanomedicine-applications
#8
Agustin S Picco, Larissa F Ferreira, Michelle S Liberato, Gabriela B Mondo, Mateus B Cardoso
AIM: To study freeze-drying of silica nanoparticles (SiO2NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. METHODS: SiO2NPs were synthesized using a Stöber-based procedure, and characterized by scanning electron microscopy, dynamic light scattering and nitrogen adsorption/desorption isotherms. SiO2NPs hydrodynamic diameters were compared prior and after freeze-drying in the presence/absence of carbohydrate protectants...
November 15, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29044359/management-della-retinopatia-diabetica-e-dell-edema-maculare-diabetico-linee-guida-euretina-2017
#9
P Turchetti, A Librando, F Angelucci, S C Carlesimo, R Migliorini
Si prevede che la malattia diabetica con tutte le sue complicanze avrà un forte aumento di incidenza con un grosso impatto socioeconomico nei prossimi decenni in tutto il mondo. Pertanto ben si comprende l'importanza di individuare attraverso una fine diagnostica quanto più precocemente la comparsa dei sintomi diabetici, migliorare lo stile di vita ed impostare cure efficienti. Riportiamo la serie di raccomandazioni EURETINA 2017, dei maggiori esperti in Europa per la gestione della malattia diabetica e delle complicanze della retina...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28901347/-soppressione-virologica-di-hbv-e-sviluppo-di-hcc-descrizione-di-un-caso-clinico-seguito-per-15-anni
#10
Tullio Prestileo, Francesco Di Lorenzo, Adriana Sanfilippo, Claudia Imburgia, Giuseppe Cabibbo, Salvatore Corrao
Riassunto. Tra le persone infette da HIV in tutto il mondo, tra i 2 e i 4 milioni presentano coinfezione da HBV. Questo caso clinico descrive i 15 anni di malattia di un paziente coinfettato da HBV-HIV, che ha sviluppato HCC nonostante la piena aderenza ai trattamenti e la completa soppressione virale. Nostro obiettivo è segnalare agli infettivologi il possibile sviluppo di HCC indipendentemente, nonostante l'adesione alle cure e la completa soppressione virale.
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28679849/mendelian-genes-and-risk-of-intracerebral-hemorrhage-and-small-vessel-ischemic-stroke-in-sporadic-cases
#11
Michael Chong, Martin O'Donnell, Vincent Thijs, Antonio Dans, Patricio López-Jaramillo, Diego Gómez-Arbeláez, Charles Mondo, Anna Czlonkowska, Marta Skowronska, Shahram Oveisgharan, Salim Yusuf, Guillaume Paré
BACKGROUND AND PURPOSE: Mendelian strokes are rare genetic disorders characterized by early-onset small-vessel stroke. Although extensively studied among families with syndromic features, whether these genes affect risk among sporadic cases is unknown. METHODS: We sequenced 8 genes responsible for Mendelian stroke in a case-control study of sporadic stroke cases (≤70 years). Participants included 1251 primary stroke cases of small-vessel pathology (637 intracerebral hemorrhage and 614 small-vessel ischemic stroke cases) and 1716 controls from the INTERSTROKE study (Study of the Importance of Conventional and Emerging Risk Factors of Stroke in Different Regions and Ethnic Groups of the World)...
August 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28631776/-panoramica-sui-risultati-degli-studi-pre-clinici-sugli-effetti-dell-epigallocatechina-gallato-la-pi%C3%A3-abbondante-catechina-presente-nel-t%C3%A3-verde-nel-trattamento-del-cancro-al-pancreas
#12
Sabrina Bimonte, Marco Cascella, Maddalena Leongito, Raffaele Palaia, Domenico Caliendo, Francesco Izzo, Arturo Cuomo
Riassunto. Il tumore del pancreas è una delle principali cause di mortalità e morbilità in tutto il mondo. Nonostante la resezione chirurgica rimanga il trattamento elettivo per questa malattia, solo una minoranza dei pazienti è candidata a intervento chirurgico, in quanto la diagnosi è molto spesso tardiva. Recentemente, nuovi schemi di chemioterapia con la combinazione di diversi farmaci, come il FOLFIRINOX (5-FU, leucovorina, irinotecan, and oxaliplatino), hanno mostrato di migliorare la sopravvivenza libera da progressione di malattia...
June 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28555641/a-parts-list-for-fungal-cellulosomes-revealed-by-comparative-genomics
#13
Charles H Haitjema, Sean P Gilmore, John K Henske, Kevin V Solomon, Randall de Groot, Alan Kuo, Stephen J Mondo, Asaf A Salamov, Kurt LaButti, Zhiying Zhao, Jennifer Chiniquy, Kerrie Barry, Heather M Brewer, Samuel O Purvine, Aaron T Wright, Matthieu Hainaut, Brigitte Boxma, Theo van Alen, Johannes H P Hackstein, Bernard Henrissat, Scott E Baker, Igor V Grigoriev, Michelle A O'Malley
Cellulosomes are large, multiprotein complexes that tether plant biomass-degrading enzymes together for improved hydrolysis(1). These complexes were first described in anaerobic bacteria, where species-specific dockerin domains mediate the assembly of enzymes onto cohesin motifs interspersed within protein scaffolds(1). The versatile protein assembly mechanism conferred by the bacterial cohesin-dockerin interaction is now a standard design principle for synthetic biology(2,3). For decades, analogous structures have been reported in anaerobic fungi, which are known to assemble by sequence-divergent non-catalytic dockerin domains (NCDDs)(4)...
May 30, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28514783/dialysis-access-as-an-area-of-improvement-in-elderly-incident-hemodialysis-patients-results-from-a-cohort-study-from-the-international-monitoring-dialysis-outcomes-initiative
#14
Jochen G Raimann, Claudia Barth, Len A Usvyat, Priscila Preciado, Bernard Canaud, Michael Etter, Xiaoqi Xu, Adrian Guinsburg, Christina Marelli, Neill Duncan, Albert Power, Frank M van der Sande, Jeroen P Kooman, Stephan Thijssen, Yuedong Wang, Peter Kotanko
BACKGROUND: Commencing hemodialysis (HD) using a catheter is associated with a higher risk of adverse outcomes, and early conversion from central-venous catheter (CVC) to arteriovenous fistula/graft (non-CVC) improves outcomes. We investigated CVC prevalence and conversion, and their effects on outcomes during the first year of HD in a multinational cohort of elderly patients. METHODS: Patients ≥70 years from the MONDO Initiative who commenced HD between 2000 and 2010 in Asia-Pacific, Europe, North-, and South-America and survived at least 6 months were included in this investigation...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28481340/widespread-adenine-n6-methylation-of-active-genes-in-fungi
#15
Stephen J Mondo, Richard O Dannebaum, Rita C Kuo, Katherine B Louie, Adam J Bewick, Kurt LaButti, Sajeet Haridas, Alan Kuo, Asaf Salamov, Steven R Ahrendt, Rebecca Lau, Benjamin P Bowen, Anna Lipzen, William Sullivan, Bill B Andreopoulos, Alicia Clum, Erika Lindquist, Christopher Daum, Trent R Northen, Govindarajan Kunde-Ramamoorthy, Robert J Schmitz, Andrii Gryganskyi, David Culley, Jon Magnuson, Timothy Y James, Michelle A O'Malley, Jason E Stajich, Joseph W Spatafora, Axel Visel, Igor V Grigoriev
N6-methyldeoxyadenine (6mA) is a noncanonical DNA base modification present at low levels in plant and animal genomes, but its prevalence and association with genome function in other eukaryotic lineages remains poorly understood. Here we report that abundant 6mA is associated with transcriptionally active genes in early-diverging fungal lineages. Using single-molecule long-read sequencing of 16 diverse fungal genomes, we observed that up to 2.8% of all adenines were methylated in early-diverging fungi, far exceeding levels observed in other eukaryotes and more derived fungi...
June 2017: Nature Genetics
https://www.readbyqxmd.com/read/28476564/global-mortality-variations-in-patients-with-heart-failure-results-from-the-international-congestive-heart-failure-inter-chf-prospective-cohort-study
#16
Hisham Dokainish, Koon Teo, Jun Zhu, Ambuj Roy, Khalid F AlHabib, Ahmed ElSayed, Lia Palileo-Villaneuva, Patricio Lopez-Jaramillo, Kamilu Karaye, Khalid Yusoff, Andres Orlandini, Karen Sliwa, Charles Mondo, Fernando Lanas, Dorairaj Prabhakaran, Amr Badr, Mohamed Elmaghawry, Albertino Damasceno, Kemi Tibazarwa, Emilie Belley-Cote, Kumar Balasubramanian, Shofiqul Islam, Magdi H Yacoub, Mark D Huffman, Karen Harkness, Alex Grinvalds, Robert McKelvie, Shrikant I Bangdiwala, Salim Yusuf
BACKGROUND: Most data on mortality and prognostic factors in patients with heart failure come from North America and Europe, with little information from other regions. Here, in the International Congestive Heart Failure (INTER-CHF) study, we aimed to measure mortality at 1 year in patients with heart failure in Africa, China, India, the Middle East, southeast Asia and South America; we also explored demographic, clinical, and socioeconomic variables associated with mortality. METHODS: We enrolled consecutive patients with heart failure (3695 [66%] clinic outpatients, 2105 [34%] hospital in patients) from 108 centres in six geographical regions...
May 3, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28403938/mondoa-chrebp-the-usual-suspects-of-transcriptional-glucose-sensing-implication-in-pathophysiology
#17
REVIEW
Paul Richards, Sarah Ourabah, Jacques Montagne, Anne-Françoise Burnol, Catherine Postic, Sandra Guilmeau
Identification of the Mondo glucose-responsive transcription factors family, including the MondoA and MondoB/ChREBP paralogs, has shed light on the mechanism whereby glucose affects gene transcription. They have clearly emerged, in recent years, as key mediators of glucose sensing by multiple cell types. MondoA and ChREBP have overlapping yet distinct expression profiles, which underlie their downstream targets and separate roles in regulating genes involved in glucose metabolism. MondoA can restrict glucose uptake and influences energy utilization in skeletal muscle, while ChREBP signals energy storage through de novo lipogenesis in liver and white adipose tissue...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28372551/kidney-disease-in-uganda-a-community-based-study
#18
Robert Kalyesubula, Joaniter I Nankabirwa, Isaac Ssinabulya, Trishul Siddharthan, James Kayima, Jane Nakibuuka, Robert A Salata, Charles Mondo, Moses R Kamya, Donald Hricik
BACKGROUND: Chronic kidney disease (CKD) is a major cause of morbidity and mortality in Sub-Saharan Africa (SSA). The majority of studies on CKD in SSA have been conducted among HIV-infected populations and mainly from large health facilities. We determined the prevalence of CKD and its predictors among populations in communities in central Uganda. METHODS: A cross-sectional study was conducted in Wakiso district using multi-stage sampling. Data was collected on age, sex, socio-economic status, history of alcohol intake, diabetes mellitus, hypertension and smoking...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28350543/mondo-a-neutron-tracker-for-particle-therapy-secondary-emission-characterisation
#19
M Marafini, L Gasparini, R Mirabelli, D Pinci, V Patera, A Sciubba, E Spiriti, D Stoppa, G Traini, A Sarti
Tumour control is performed in particle therapy using particles and ions, whose high irradiation precision enhances the effectiveness of the treatment, while sparing the healthy tissue surrounding the target volume. Dose range monitoring devices using photons and charged particles produced by the beam interacting with the patient's body have already been proposed, but no attempt has been made yet to exploit the detection of the abundant neutron component. Since neutrons can release a significant dose far away from the tumour region, precise measurements of their flux, production energy and angle distributions are eagerly sought in order to improve the treatment planning system (TPS) software...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28283851/serum-ferritin-as-an-indicator-of-the-development-of-encephalopathy-in-enterohemorrhagic-escherichia-coli-induced-hemolytic-uremic-syndrome
#20
Masaki Shimizu, Natsumi Inoue, Mondo Kuroda, Hitoshi Irabu, Maiko Takakura, Hisashi Kaneda, Naotoshi Sugimoto, Kazuhide Ohta, Akihiro Yachie
OBJECTIVES: To investigate the diagnostic value of serum ferritin levels as a marker of disease activity and the development of encephalopathy in hemolytic uremic syndrome (HUS) induced by enterohemorrhagic Escherichia coli. METHODS: Twenty patients with HUS were studied. Serum ferritin levels were compared with clinical features and serum soluble tumor necrosis factor receptor (sTNFR) I and sTNFRII levels. Serum sTNFRI and sTNFRII levels were quantified by enzyme-linked immunosorbent assays...
March 10, 2017: Clinical and Experimental Nephrology
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