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REVIEW
Alberto Catalano, Lorenzo Milani, Matteo Franco, Federica Buscema, Ilenia Giommarini, Barbara Sodano, Winston Gilcrease, Luisa Mondo, Michele Marra, Chiara Di Girolamo, Antonella Bena, Fulvio Ricceri
BACKGROUND AND AIMS: Since the COVID-19 outbreak, people's habits changed radically. In fact, to limit the spread of SARS-CoV-2, governments implemented restrictive measures that influenced the lives of individuals. The aim of this systematic review is to analyze the impact of COVID-19 on gambling by examining three different outcomes: frequency, expenditure, and transition among possible types of gambling. METHODS: All studies assessing the impact of restrictive measures implemented to limit the spread of SARS-CoV-2 on gambling were included...
April 10, 2024: Addictive Behaviors
#2
JOURNAL ARTICLE
Raffaele Scarpellini, Laura Leal Vélez De Mendizábal, Sergio Quevedo-Caraballo, José L Blanco, Marta E García, Marta Pérez-Sancho, Miriam Portero Fuentes, Silvia Penelo, Erika Esposito, Elisabetta Mondo, Silvia Piva
The role of small animal veterinary hospitals in the onset and dissemination of antimicrobial-resistant organisms (AMROs) is still not clear, and the implementation of an internal surveillance systems is a cost-effective tool to better understand their impact. The aim of this study was to describe a pilot program of active surveillance in a Spanish Veterinary Teaching Hospital, developed to estimate the detection frequency of AMROs in the commensal flora of patients and in the environment. Surveillance was focused on Methicillin-resistant Staphylococci (MRS), third generation cephalosporins resistant gram-negative bacteria (3GCR-GNB), and carbapenems-resistant gram-negative bacteria (CR-GNB)...
April 2, 2024: Comparative Immunology, Microbiology and Infectious Diseases
#3
JOURNAL ARTICLE
Benedetto Saraceno
We report in this issue a contribution by Benedetto Saraceno, published in Salute Internazionale (https://www.saluteinternazionale.info), commenting on the WHO 2022 report on mental health in the world. The comment highlights the progresses but also the presence, beyond declarations of principle, of large psychiatric institutions. There is still a long way to go to defend the rights of people with psychiatric problems.
2024: Assistenza Infermieristica e Ricerca: AIR
#4
JOURNAL ARTICLE
Xiaoxuan Qin, Liang Jiang, Ping Zhao, Ying Lin, Yi Zhang, Qingyou Xia
Bombyx mori was domesticated from Bombyx mandarina . The long-term domestication of the silkworm has brought about many remarkable changes to its body size and cocoon shell weight. However, the molecular mechanism underlying the improvement in the economic characteristics of this species during domestication remains unclear. In this study, we found that a transposable element (TE)-Bm1-was present in the upstream regulatory region of the Mlx (Max-like protein X) gene in wild silkworms but not in all domesticated silkworms...
March 18, 2024: International Journal of Molecular Sciences
#5
JOURNAL ARTICLE
Giampaolo Collecchia
Humans are social creatures, and touch is the most primitive form of relationship. In the context of the traditional medical examination, touch, palpation, is essential to diagnose or suspect pathology. But it is not only an issue of semeiotics. The physician's ability to examine a body through his or her hands is at the heart of the doctor-patient relationship. Moreover, we have been witnessing for many years to the progressive downgrading of the objective examination in clinical practice. First, the obsolescence of interaction with the patient due to the lure of diagnostic technology, then the "social distancing" of Covid-19 and, finally, the expansion of telemedicine has contributed to the distancing of caregivers from patients...
April 2024: Recenti Progressi in Medicina
#6
JOURNAL ARTICLE
Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case-control study.
Xingyu Wang, Xin Liu, Martin J O'Donnell, Matthew McQueen, Allan Sniderman, Guillaume Pare, Graeme J Hankey, Sumathy Rangarajan, Siu Lim Chin, Purnima Rao-Melacini, John Ferguson, Denis Xavier, Hongye Zhang, Lisheng Liu, Prem Pais, Patricio Lopez-Jaramillo, Albertino Damasceno, Peter Langhorne, Annika Rosengren, Antonio L Dans, Ahmed Elsayed, Alvaro Avezum, Charles Mondo, Conor Judge, Hans-Christoph Diener, Danuta Ryglewicz, Anna Czlonkowska, Nana Pogosova, Christian Weimar, Romana Iqbal, Rafael Diaz, Khalid Yusoff, Afzalhussein Yusufali, Aytekin Oguz, Ernesto Penaherrera, Fernando Lanas, Okechukwu S Ogah, A Ogunniyi, Helle K Iversen, German Malaga, Zvonko Rumboldt, Shahram Oveisgharan, Fawaz Al Hussain, Yongchai Nilanont, Salim Yusuf
BACKGROUND: Smoking is a major risk factor for the global burden of stroke. We have previously reported a global population attributable risk (PAR) of stroke of 12.4% associated with current smoking. In this study we aimed to explore the association of current tobacco use with different types of tobacco exposure and environmental tobacco smoke (ETS) exposure on the risk of stroke and stroke subtypes, and by regions and country income levels. METHODS: The INTERSTROKE study is a case-control study of acute first stroke and was undertaken with 13,462 stroke cases and 13,488 controls recruited between January 11, 2007 and August 8, 2015 in 32 countries worldwide...
April 2024: EClinicalMedicine
#7
JOURNAL ARTICLE
Mondo Yoshizawa, Yoshiyuki Tamura, Asami Yasuda-Ohata, Shinsuke Yoshihara, Hideki Takasaki, Sadayuki Hashioka
The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is unclear. According to the cortical hypothesis, severe RBD episode (RBDE) occurs when spinal motoneurons are less inhibited and cortical and limbic systems are more active. We made this study to prove the hypothesis for the development of RBDE using video-polysomnography (VPSG). VPSG records of 35 patients with RBD were analyzed. According to severity, RBDEs were classified into three motor events (MEs): ME 1; small movements or jerks, ME 2; proximal movements including violent behavior, and ME 3; axial movements including bed falls...
October 2023: Sleep and Biological Rhythms
#8
JOURNAL ARTICLE
Marco Ambrosetti, Nuccia Morici, Carmine Riccio, Fabrizio Oliva
No abstract text is available yet for this article.
March 2024: Giornale Italiano di Cardiologia
#9
Gian P Sepulveda, Ekaterina S Gushchanskaia, Alexandra Mora-Martin, Ruben Esse, Iana Nikorich, Ainhoa Ceballos, Julian Kwan, Benjamin C Blum, Prakruti Dholiya, Andrew Emili, Valentina Perissi, Maria D Cardamone, Alla Grishok
The proto-oncogene c-MYC is a key representative of the MYC transcription factor network regulating growth and metabolism. MML-1 (Myc- and Mondo-like) is its homolog in C. elegans . The functional and molecular cooperation between c-MYC and H3 lysine 79 methyltransferase DOT1L was demonstrated in several human cancer types, and we have earlier discovered the connection between C. elegans MML-1 and DOT-1.1. Here, we demonstrate the critical role of DOT1L/DOT-1.1 in regulating c-MYC/MML-1 target genes genome-wide by ensuring the removal of "spent" transcription factors from chromatin by the nuclear proteasome...
February 7, 2024: bioRxiv
#10
JOURNAL ARTICLE
Katharina O Barros, Megan Mader, David J Krause, Jasmyn Pangilinan, Bill Andreopoulos, Anna Lipzen, Stephen J Mondo, Igor V Grigoriev, Carlos A Rosa, Trey K Sato, Chris Todd Hittinger
BACKGROUND: Cost-effective production of biofuels from lignocellulose requires the fermentation of D-xylose. Many yeast species within and closely related to the genera Spathaspora and Scheffersomyces (both of the order Serinales) natively assimilate and ferment xylose. Other species consume xylose inefficiently, leading to extracellular accumulation of xylitol. Xylitol excretion is thought to be due to the different cofactor requirements of the first two steps of xylose metabolism. Xylose reductase (XR) generally uses NADPH to reduce xylose to xylitol, while xylitol dehydrogenase (XDH) generally uses NAD+ to oxidize xylitol to xylulose, creating an imbalanced redox pathway...
February 7, 2024: Biotechnol Biofuels Bioprod
#11
JOURNAL ARTICLE
Ilaria Resci, Laura Zavatta, Silvia Piva, Elisabetta Mondo, Sergio Albertazzi, Antonio Nanetti, Laura Bortolotti, Giovanni Cilia
The rise of antimicrobial resistance (AMR) is one of the most relevant problems for human and animal health. According to One Health Approach, it is important to regulate the use of antimicrobials and monitor the spread of AMR in the environment as well. Apis mellifera (L. 1758) colonies were used as bioindicators thanks to their physical and behavioural characteristics. During their foraging flights, bees can intercept small particles, including atmospheric particulate matter, etc., and also microorganisms...
January 30, 2024: Environmental Research
#12
JOURNAL ARTICLE
Davis Mathieu, Abigail E Bryson, Britta Hamberger, Vasanth Singan, Keykhosrow Keymanesh, Mei Wang, Kerrie Barry, Stephen Mondo, Jasmyn Pangilinan, Maxim Koriabine, Igor V Grigoriev, Gregory Bonito, Björn Hamberger
The model moss species Physcomitrium patens has long been used for studying divergence of land plants spanning from bryophytes to angiosperms. In addition to its phylogenetic relationships, the limited number of differential tissues, and comparable morphology to the earliest embryophytes provide a system to represent basic plant architecture. Based on plant-fungal interactions today, it is hypothesized these kingdoms have a long-standing relationship, predating plant terrestrialization. Mortierellaceae have origins diverging from other land fungi paralleling bryophyte divergence, are related to arbuscular mycorrhizal fungi but are free-living, observed to interact with plants, and can be found in moss microbiomes globally...
January 24, 2024: Plant Journal
#13
JOURNAL ARTICLE
Robert Murphy, Albertino Damasceno, Catriona Reddin, Graeme J Hankey, Helle K Iversen, Shahram Oveisgharan, Fernando Lanas, Anna Czlonkowska, Peter Langhorne, Adesola Ogunniyi, Mohammad Wasay, Zvonko Rumboldt, Conor Judge, Aytekin Oguz, Charles Mondo, Yaroslav Winter, Annika Rosengren, Nana Pogosova, Alvaro Avezum, Yongchai Nilanont, Ernesto Penaherrera, Denis Xavier, Patricio Lopez-Jaramillo, Xingyu Wang, Salim Yusuf, Martin O'Donnell
BACKGROUND: The contribution of atrial fibrillation (AF) to the etiology and burden of stroke may vary by country income level. AIMS: We examined differences in the prevalence of AF and described variations in the magnitude of the association between AF and ischemic stroke by country income level. METHODS: In the INTERSTROKE case-control study, participants with acute first ischemic stroke were recruited across 32 countries. We included 10,363 ischemic stroke cases and 10,333 community or hospital controls who were matched for age, sex, and center...
January 30, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
#14
REVIEW
Ilaria Mondo, Sophia Hannou, Patrizia D'Amelio
INTRODUCTION: Osteoporosis, which is characterized by compromised bone density and heightened susceptibility to fractures, is a substantial public health concern, especially among the aging population. Underdiagnosis, undertreatment, and therapy non-adherence contribute to its impact. Anabolic and dual-action agents like teriparatide, abaloparatide, and romosozumab have emerged as effective treatments, allowing rapid gains in bone mineral density (BMD) and reducing fracture risk. However, administering treatments in the correct order is paramount, with an 'anabolic first' approach gaining traction for patients at high risk of fractures...
2023: Expert Opinion on Pharmacotherapy
#15
Edward K Maybury, Nnamdi I Gwacham, Charanjeet Singh, Susan Mondo, Sarfraz Ahmad, Nathalie D McKenzie
Non-gestational ovarian choriocarcinoma (NGOC) is a rare phenomenon seldom reported in the literature. Patients often present with abdominopelvic pain, and sometimes a palpable adnexal mass. Surgical excision is paramount in treating this malignancy; however, fertility-preserving care is a debated topic among gynecologic oncologists. Most patients reported in the literature are nulliparous women of child-bearing age. It is important to consider fertility preservation whilst balancing oncologic outcomes. We present a case of an 18-year-old nulliparous female with stage IIB NGOC that had disease progression in the lungs and pelvis shortly after undergoing fertility-preserving surgery...
December 2023: Gynecologic Oncology Reports
#16
JOURNAL ARTICLE
Leigh C Carmody, Michael A Gargano, Sabrina Toro, Nicole A Vasilevsky, Margaret P Adam, Hannah Blau, Lauren E Chan, David Gomez-Andres, Rita Horvath, Megan L Kraus, Markus S Ladewig, David Lewis-Smith, Hanns Lochmüller, Nicolas A Matentzoglu, Monica C Munoz-Torres, Catharina Schuetz, Berthold Seitz, Morgan N Similuk, Teresa N Sparks, Timmy Strauss, Emilia M Swietlik, Rachel Thompson, Xingmin Aaron Zhang, Christopher J Mungall, Melissa A Haendel, Peter N Robinson
BACKGROUND: Navigating the clinical literature to determine the optimal clinical management for rare diseases presents significant challenges. We introduce the Medical Action Ontology (MAxO), an ontology specifically designed to organize medical procedures, therapies, and interventions. METHODS: MAxO incorporates logical structures that link MAxO terms to numerous other ontologies within the OBO Foundry. Term development involves a blend of manual and semi-automated processes...
November 9, 2023: Med
#17
JOURNAL ARTICLE
Jean M Mondo, Paterne A Agre, Géant B Chuma, Robert Asiedu, Malachy O Akoroda, Asrat Asfaw
Developing novel white Guinea yam ( Dioscorea rotundata ) varieties is constrained by the sparse, erratic, and irregular flowering behavior of most genotypes. We tested the effectiveness of nine agronomic and hormonal treatments to enhance flowering on D. rotundata under field conditions. Genotypes responded differently to flower-inducing treatments ( p <0.001). Of the test treatments, pruning and silver thiosulfate (STS) were effective in increasing the number of spikes per plant and the flowering intensity on both sparse flowering and monoecious cultivars...
2023: Frontiers in Plant Science
#18
JOURNAL ARTICLE
Francesca Zambri, Anna Maria Nannavecchia, Sonia Brescianini, Franca Rusconi, Edoardo Corsi Decenti, Monia Puglia, Martina Pacifici, Pietro Buono, Sara Cantoira, Luigi Gagliardi, Paola Ghiotti, Olivia Leoni, Caterina Masè, Monica Mazzucato, Luisa Mondo, Edda Pellegrini, Riccardo Pertile, Alessandro Scoppa, Laura Visonà Dalla Pozza, Angela Giusti
OBJECTIVES: to describe the monthly trend of breastfeeding during hospitalization and the presence of companion of woman's choice during labour and birth, and the key regional responders' perspective of homogeneity/heterogeneity of the presence of the support person, before, during (February-May 2020), and after the first COVID-19 pandemic wave in a few Italian Regions. DESIGN: two-phase study. SETTING AND PARTICIPANTS: data from the italian birth certificate of six Italian Regions between 01...
2023: Epidemiologia e Prevenzione
#19
JOURNAL ARTICLE
Noah Hensen, Lucas Bonometti, Ivar Westerberg, Ioana Onut Brännström, Sonia Guillou, Sandrine Cros-Aarteil, Sara Calhoun, Sajeet Haridas, Alan Kuo, Stephen Mondo, Jasmyn Pangilinan, Robert Riley, Kurt LaButti, Bill Andreopoulos, Anna Lipzen, Cindy Chen, Mi Yan, Chris Daum, Vivian Ng, Alicia Clum, Andrei Steindorff, Robin A Ohm, Francis Martin, Philippe Silar, Donald O Natvig, Christophe Lalanne, Valérie Gautier, Sandra Lorena Ament-Velásquez, Åsa Kruys, Miriam I Hutchinson, Amy Jo Powell, Kerrie Barry, Andrew N Miller, Igor V Grigoriev, Robert Debuchy, Pierre Gladieux, Markus Hiltunen Thorén, Hanna Johannesson
The order Sordariales is taxonomically diverse, and harbours many species with different lifestyles and large economic importance. Despite its importance, a robust genome-scale phylogeny, and associated comparative genomic analysis of the order is lacking. In this study, we examined whole-genome data from 99 Sordariales, including 52 newly sequenced genomes, and seven outgroup taxa. We inferred a comprehensive phylogeny that resolved several contentious relationships amongst families in the order, and cleared-up intrafamily relationships within the Podosporaceae...
October 10, 2023: Molecular Phylogenetics and Evolution
#20
JOURNAL ARTICLE
Elisa Bertolini, Giulia Babbi, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio
MultifacetedProtDB is a database of multifunctional human proteins deriving information from other databases, including UniProt, GeneCards, Human Protein Atlas (HPA), Human Phenotype Ontology (HPO) and MONDO. It collects under the label 'multifaceted' multitasking proteins addressed in literature as pleiotropic, multidomain, promiscuous (in relation to enzymes catalysing multiple substrates) and moonlighting (with two or more molecular functions), and difficult to be retrieved with a direct search in existing non-specific databases...
October 4, 2023: Nucleic Acids Research
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