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https://www.readbyqxmd.com/read/29774710/-prevalence-of-acid-burns-among-asylum-seekers-hosted-in-an-initial-reception-centre-as-an-example-of-health-assessment-in-a-fragile-population
#1
Fulvio Ricceri, Veronica Sciannameo, Federico De Michelis, Lucia Perucca, Luisa Mondo, Roberto Raffaele Pepe, Carlotta Sacerdote
OBJECTIVES: to evaluate the prevalence of acid burns among asylum seekers hosted in an initial reception centre and to evaluate if the prevalence is reduced after the introduction of the European Union (EU) regulation No. 29 (14th September 2016) that indirectly reduced the permanence time of the subjects on board of boats. DESIGN: cross-sectional study. SETTING AND PARTICIPANTS: 10,627 asylum seekers hosted in the centre for initial reception of Piedmont and Valle d'Aosta Regions (Northern Italy) between June 2016 and May 2017...
March 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29771364/broad-genomic-sampling-reveals-a-smut-pathogenic-ancestry-of-the-fungal-clade-ustilaginomycotina
#2
Teeratas Kijpornyongpan, Stephen J Mondo, Kerrie Barry, Laura Sandor, Juna Lee, Anna Lipzen, Jasmyn Pangilinan, Kurt LaButti, Matthieu Hainaut, Bernard Henrissat, Igor V Grigoriev, Joseph W Spatafora, M Catherine Aime
Ustilaginomycotina is home to a broad array of fungi including important plant pathogens collectively called smut fungi. Smuts are biotrophs that produce characteristic perennating propagules called teliospores, one of which, Ustilago maydis, is a model genetic organism. Broad exploration of smut biology has been hampered by limited phylogenetic resolution of Ustilaginiomycotina as well as an overall lack of genomic data for members of this subphylum. In this study, we sequenced eight Ustilaginomycotina genomes from previously unrepresented lineages, deciphered ordinal-level phylogenetic relationships for the subphylum, and performed comparative analyses...
May 15, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29750228/hypertension-among-newly-diagnosed-diabetic-patients-at-mulago-national-referral-hospital-in-uganda-a-cross-sectional-study
#3
Martin Muddu, Edrisa Mutebi, Isaac Ssinabulya, Samuel Kizito, Charles Kiiza Mondo
BACKGROUND: The prevalence of hypertension in patients with diabetes is approximately two-fold higher than in age-matched subjects without the disease and, conversely, individuals with hypertension are at increased risk of developing diabetes compared with normotensive persons. Up to 75% of cases of cardiovascular disease (CVD) in patients with diabetes are attributed to hypertension. Diabetics who have hypertension are more likely to develop complications and die, and appropriate blood pressure control in these individuals reduces the risk...
April 20, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29718469/pre-dialysis-fluid-status-pre-dialysis-systolic-blood-pressure-and-outcome-in-prevalent-haemodialysis-patients-results-of-an-international-cohort-study-on-behalf-of-the-mondo-initiative
#4
Marijke Dekker, Constantijn Konings, Bernard Canaud, Paola Carioni, Adrian Guinsburg, Magdalena Madero, Jeroen van der Net, Jochen Raimann, Frank van der Sande, Stefano Stuard, Len Usvyat, Yuedong Wang, Xiaoqi Xu, Peter Kotanko, Jeroen Kooman
Background: Pre-dialysis fluid overload (FO) associates with mortality and causes elevated pre-dialysis systolic blood pressure (pre-SBP). However, low pre-SBP is associated with increased mortality in haemodialysis patients. The objective of this study was to investigate the interaction between pre-dialysis fluid status (FS) and pre-SBP in association with mortality. Methods: We included all patients from the international Monitoring Dialysis Outcome Initiative (MONDO) database with a pre-dialysis multifrequency bioimpedance spectroscopy measurement in the year 2011...
April 27, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29674435/phylogenetic-and-phylogenomic-definition-of-rhizopus-species
#5
Andrii P Gryganskyi, Jacob Golan, Somayeh Dolatabadi, Stephen Mondo, Sofia Robb, Alexander Idnurm, Anna Muszewska, Kamil Steczkiewicz, Sawyer Masonjones, Hui-Ling Liao, Michael T Gajdeczka, Felicia Anike, Antonina Vuek, Iryna M Anishchenko, Kerstin Voigt, G Sybren de Hoog, Matthew E Smith, Joseph Heitman, Rytas Vilgalys, Jason E Stajich
Phylogenomic approaches have the potential to improve confidence about the inter-relationships of species in the order Mucorales within the fungal tree of life. Rhizopus species are especially important as plant and animal pathogens and bioindustrial fermenters for food and metabolite production. A dataset of 192 orthologous genes was used to construct a phylogenetic tree of 21 Rhizopus strains, classified into four species isolated from habitats of industrial, medical and environmental importance. The phylogeny indicates that the genus Rhizopus consists of three major clades, with R...
April 19, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29521624/functional-genomics-of-lipid-metabolism-in-the-oleaginous-yeast-rhodosporidium-toruloides
#6
Samuel T Coradetti, Dominic Pinel, Gina M Geiselman, Masakazu Ito, Stephen J Mondo, Morgann C Reilly, Ya-Fang Cheng, Stefan Bauer, Igor V Grigoriev, John M Gladden, Blake A Simmons, Rachel B Brem, Adam P Arkin, Jeffrey M Skerker
The basidiomycete yeast Rhodosporidium toruloides (also known as Rhodotorula toruloides ) accumulates high concentrations of lipids and carotenoids from diverse carbon sources. It has great potential as a model for the cellular biology of lipid droplets and for sustainable chemical production. We developed a method for high-throughput genetics (RB-TDNAseq), using sequence-barcoded Agrobacterium tumefaciens T-DNA insertions. We identified 1,337 putative essential genes with low T-DNA insertion rates. We functionally profiled genes required for fatty acid catabolism and lipid accumulation, validating results with 35 targeted deletion strains...
March 9, 2018: ELife
https://www.readbyqxmd.com/read/29488461/effectiveness-of-a-household-water-sanitation-and-hygiene-package-on-an-outpatient-program-for-severe-acute-malnutrition-a-pragmatic-cluster-randomized-controlled-trial-in-chad
#7
Mathias Altmann, Chiara Altare, Nanette van der Spek, Jean-Christophe Barbiche, Jovana Dodos, Mahamat Bechir, Myriam Ait Aissa, Patrick Kolsteren
Water, sanitation and hygiene (WASH) interventions have a small but measurable benefit on stunting, but not on wasting. Our objective was to assess the effectiveness of a household WASH package on the performance of an Outpatient Therapeutic feeding Program (OTP) for severe acute malnutrition (SAM). We conducted a cluster-randomized controlled trial embedded in a routine OTP. The study population included 20 health centers (clusters) from Mao and Mondo districts in Chad. Both arms received the OTP. The intervention arm received an additional household WASH package (chlorine, soap, water storage container, and promotion on its use)...
April 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29478048/association-between-heights-of-dialysis-patients-and-outcomes-results-from-a-retrospective-cohort-study-of-the-international-monitoring-dialysis-outcomes-mondo-database-initiative
#8
Samir Patel, Alice Topping, Xiaoling Ye, Hanjie Zhang, Bernard Canaud, Paola Carioni, Cristina Marelli, Adrian Guinsburg, Albert Power, Neill Duncan, Jeroen Kooman, Frank van der Sande, Len A Usvyat, Yuedong Wang, Xiaoqi Xu, Peter Kotanko, Jochen G Raimann
BACKGROUND: Tall people have improved metabolic profiles and better cardiovascular outcomes, a relationship inverted in dialysis patients. We investigated the relationship between height and outcomes in incident hemodialysis (HD) patients commencing treatment in an analysis of the international Monitoring Dialysis Outcomes (MONDO) database. METHODS: In this retrospective cohort study, we included incident HD patients commencing treatment between -January 1, 2006 and December 31, 2010 and investigated the association between height and mortality using the MONDO database...
2018: Blood Purification
https://www.readbyqxmd.com/read/29466741/rap1-negatively-regulates-the-hippo-pathway-to-polarize-directional-protrusions-in-collective-cell-migration
#9
Yu-Chiuan Chang, Jhen-Wei Wu, Yi-Chi Hsieh, Tzu-Han Huang, Zih-Min Liao, Yi-Shan Huang, James A Mondo, Denise Montell, Anna C-C Jang
In collective cell migration, directional protrusions orient cells in response to external cues, which requires coordinated polarity among the migrating cohort. However, the molecular mechanism has not been well defined. Drosophila border cells (BCs) migrate collectively and invade via the confined space between nurse cells, offering an in vivo model to examine how group polarity is organized. Here, we show that the front/back polarity of BCs requires Rap1, hyperactivation of which disrupts cluster polarity and induces misoriented protrusions and loss of asymmetry in the actin network...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29370695/autophagy-and-longevity
#10
REVIEW
Shuhei Nakamura, Tamotsu Yoshimori
Autophagy is an evolutionally conserved cytoplasmic degradation system in which varieties of materials are sequestered by a double membrane structure, autophagosome, and delivered to the lysosomes for the degradation. Due to the wide varieties of targets, autophagic activity is essential for cellular homeostasis. Recent genetic evidence indicates that autophagy has a crucial role in the regulation of animal lifespan. Basal level of autophagic activity is elevated in many longevity paradigms and the activity is required for lifespan extension...
January 31, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29317534/linking-secondary-metabolites-to-gene-clusters-through-genome-sequencing-of-six-diverse-aspergillus-species
#11
Inge Kjærbølling, Tammi C Vesth, Jens C Frisvad, Jane L Nybo, Sebastian Theobald, Alan Kuo, Paul Bowyer, Yudai Matsuda, Stephen Mondo, Ellen K Lyhne, Martin E Kogle, Alicia Clum, Anna Lipzen, Asaf Salamov, Chew Yee Ngan, Chris Daum, Jennifer Chiniquy, Kerrie Barry, Kurt LaButti, Sajeet Haridas, Blake A Simmons, Jon K Magnuson, Uffe H Mortensen, Thomas O Larsen, Igor V Grigoriev, Scott E Baker, Mikael R Andersen
The fungal genus of Aspergillus is highly interesting, containing everything from industrial cell factories, model organisms, and human pathogens. In particular, this group has a prolific production of bioactive secondary metabolites (SMs). In this work, four diverse Aspergillus species ( A. campestris , A. novofumigatus , A. ochraceoroseus , and A. steynii ) have been whole-genome PacBio sequenced to provide genetic references in three Aspergillus sections. A. taichungensis and A. candidus also were sequenced for SM elucidation...
January 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29278834/sugar-sensing-by-chrebp-mondo-mlx-new-insight-into-downstream-regulatory-networks-and-integration-of-nutrient-derived-signals
#12
REVIEW
Essi Havula, Ville Hietakangas
Animals regulate their physiology with respect to nutrient status, which requires nutrient sensing pathways. Simple carbohydrates, sugars, are sensed by the basic-helix-loop-helix leucine zipper transcription factors ChREBP/Mondo, together with their heterodimerization partner Mlx, which are well-established activators of sugar-induced lipogenesis. Loss of ChREBP/Mondo-Mlx in mouse and Drosophila leads to sugar intolerance, that is, inability to survive on sugar containing diet. Recent evidence has revealed that ChREBP/Mondo-Mlx responds to sugar and fatty acid-derived metabolites through several mechanisms and cross-connects with other nutrient sensing pathways...
December 23, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29228042/risk-of-thromboembolism-in-cisplatin-versus-carboplatin-treated-patients-with-lung-cancer
#13
Eric S Kim, Andrea M Baran, Esther L Mondo, Thomas D Rodgers, Gradon C Nielsen, David W Dougherty, Kishan J Pandya, David Q Rich, Edwin van Wijngaarden
INTRODUCTION: Carboplatin is widely used to treat lung cancer in the United States as an alternative to cisplatin. Several studies have demonstrated that cisplatin-based regimen is associated with a high frequency of thromboembolic complications. However, there has been limited investigation directly comparing the risk of thromboembolic events (TEEs) between cisplatin- and carboplatin-treated patients with lung cancer. METHODS: All lung cancer patients treated with cisplatin or carboplatin at Wilmot Cancer Center, University of Rochester between 2011 and 2014 were included...
2017: PloS One
https://www.readbyqxmd.com/read/29207890/artificial-mirnas-reduce-human-mutant-huntingtin-throughout-the-striatum-in-a-transgenic-sheep-model-of-huntington-s-disease
#14
Edith L Pfister, Natalie DiNardo, Erica Mondo, Florie Borel, Faith Conroy, Cara Fraser, Gwladys Gernoux, Xin Han, Danjing Hu, Emily Johnson, Lori Kennington, PengPeng Liu, Suzanne J Reid, Ellen Sapp, Petr Vodicka, Tim Kuchel, A Jennifer Morton, David Howland, Richard Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, Marian DiFiglia, Neil Aronin
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a genetic expansion of the CAG repeat region in the huntingtin (HTT) gene. Studies in HD mouse models have shown that artificial miRNAs can reduce mutant HTT, but evidence for their effectiveness and safety in larger animals is lacking. HD transgenic sheep express the full-length human HTT with 73 CAG repeats. AAV9 was used to deliver unilaterally to HD sheep striatum an artificial miRNA targeting exon 48 of the human HTT mRNA under control of two alternative promoters: U6 or CβA...
February 23, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29184190/bacterial-endosymbionts-influence-host-sexuality-and-reveal-reproductive-genes-of-early-divergent-fungi
#15
Stephen J Mondo, Olga A Lastovetsky, Maria L Gaspar, Nicole H Schwardt, Colin C Barber, Robert Riley, Hui Sun, Igor V Grigoriev, Teresa E Pawlowska
Many heritable mutualisms, in which beneficial symbionts are transmitted vertically between host generations, originate as antagonisms with parasite dispersal constrained by the host. Only after the parasite gains control over its transmission is the symbiosis expected to transition from antagonism to mutualism. Here, we explore this prediction in the mutualism between the fungus Rhizopus microsporus (Rm, Mucoromycotina) and a beta-proteobacterium Burkholderia, which controls host asexual reproduction. We show that reproductive addiction of Rm to endobacteria extends to mating, and is mediated by the symbiont gaining transcriptional control of the fungal ras2 gene, which encodes a GTPase central to fungal reproductive development...
November 29, 2017: Nature Communications
https://www.readbyqxmd.com/read/29154287/did-you-know-that-your-animals-have-consciousness
#16
P A Accorsi, E Mondo, M Cocchi
Consciousness is the greatest enigma in human history. For centuries scientists and researchers have tried to describe it without coming to conclusions. In the last years with the neurosciences development, consciousness has become the common goal of numerous studies. But consciousness has always been studied only in humans, but after "Cambridge Declaration on Consciousness" in 2012, even non-human animalsthey feel possessed of the consciousness. According to "theory Orch-OR" of Hameroff and Penrose we have conducted a study on Alaskan malamute and German shepherd to analysed a triplet of platelet fatty acids (linoleic acid; palmitic acid; arachidonic acid)...
2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29153402/phylogenetics-and-phylogenomics-of-rust-fungi
#17
M Catherine Aime, Alistair R McTaggart, Stephen J Mondo, Sébastien Duplessis
Rust fungi (Pucciniales) are the most speciose and the most complex group of plant pathogens. Historically, rust taxonomy was largely influenced by host and phenotypic characters, which are potentially plastic. Molecular systematic studies suggest that the extant diversity of this group was largely shaped by host jumps and subsequent shifts. However, it has been challenging to reconstruct the evolutionary history for the order, especially at deeper (family-level) nodes. Phylogenomics offer a potentially powerful tool to reconstruct the Pucciniales tree of life, although researchers working at this vanguard still face unprecedented challenges working with nonculturable organisms that possess some of the largest and most repetitive genomes now known in kingdom fungi...
2017: Advances in Genetics
https://www.readbyqxmd.com/read/29139338/freeze-drying-of-silica-nanoparticles-redispersibility-toward-nanomedicine-applications
#18
Agustin S Picco, Larissa F Ferreira, Michelle S Liberato, Gabriela B Mondo, Mateus B Cardoso
AIM: To study freeze-drying of silica nanoparticles (SiO2NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. METHODS: SiO2NPs were synthesized using a Stöber-based procedure, and characterized by scanning electron microscopy, dynamic light scattering and nitrogen adsorption/desorption isotherms. SiO2NPs hydrodynamic diameters were compared prior and after freeze-drying in the presence/absence of carbohydrate protectants...
November 15, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29044359/management-della-retinopatia-diabetica-e-dell-edema-maculare-diabetico-linee-guida-euretina-2017
#19
P Turchetti, A Librando, F Angelucci, S C Carlesimo, R Migliorini
Si prevede che la malattia diabetica con tutte le sue complicanze avrà un forte aumento di incidenza con un grosso impatto socioeconomico nei prossimi decenni in tutto il mondo. Pertanto ben si comprende l'importanza di individuare attraverso una fine diagnostica quanto più precocemente la comparsa dei sintomi diabetici, migliorare lo stile di vita ed impostare cure efficienti. Riportiamo la serie di raccomandazioni EURETINA 2017, dei maggiori esperti in Europa per la gestione della malattia diabetica e delle complicanze della retina...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28901347/-soppressione-virologica-di-hbv-e-sviluppo-di-hcc-descrizione-di-un-caso-clinico-seguito-per-15-anni
#20
Tullio Prestileo, Francesco Di Lorenzo, Adriana Sanfilippo, Claudia Imburgia, Giuseppe Cabibbo, Salvatore Corrao
Riassunto. Tra le persone infette da HIV in tutto il mondo, tra i 2 e i 4 milioni presentano coinfezione da HBV. Questo caso clinico descrive i 15 anni di malattia di un paziente coinfettato da HBV-HIV, che ha sviluppato HCC nonostante la piena aderenza ai trattamenti e la completa soppressione virale. Nostro obiettivo è segnalare agli infettivologi il possibile sviluppo di HCC indipendentemente, nonostante l'adesione alle cure e la completa soppressione virale.
September 2017: Recenti Progressi in Medicina
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