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https://www.readbyqxmd.com/read/29789292/new-fines-pose-financial-catch-22-for-ontario-long-term-care
#1
Lauren Vogel
No abstract text is available yet for this article.
May 22, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29783952/differences-between-fast-and-slow-muscles-in-scallops-revealed-through-proteomics-and-transcriptomics
#2
Xiujun Sun, Zhihong Liu, Biao Wu, Liqing Zhou, Qi Wang, Wei Wu, Aiguo Yang
BACKGROUND: Scallops possess striated and catch adductor muscles, which have different structure and contractile properties. The striated muscle contracts very quickly for swimming, whereas the smooth catch muscle can keep the shells closed for long periods with little expenditure of energy. In this study, we performed proteomic and transcriptomic analyses of differences between the striated (fast) and catch (slow) adductor muscles in Yesso scallop Patinopecten yessoensis. RESULTS: Transcriptomic analysis reveals 1316 upregulated and 8239 downregulated genes in slow compared to fast adductor muscle...
May 22, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29772901/the-catch-22-of-predicting-herg-blockade-using-publicly-accessible-bioactivity-data
#3
Vishal Babu Siramshetty, Qiaofeng Chen, Prashanth Devarakonda, Robert Preissner
Drug-induced inhibition of the human Ether-à-go-go-Related Gene (hERG) encoded potassium ion (K+) channels can lead to fatal cardiotoxicity. Several marketed drugs and promising drug candidates were recalled due to this concern. Diverse modeling methods ranging from molecular similarity assessment to quantitative structure activity relationship analysis employing machine learning techniques have been applied to datasets of varying size and composition (number of blockers and non-blockers). In this study, we highlight the challenges involved in development of a robust classifier for predicting the hERG endpoint using bioactivity data extracted from the public domain...
May 17, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29758361/bone-accrual-in-oligo-amenorrheic-athletes-eumenorrheic-athletes-and-non-athletes
#4
Vibha Singhal, Karen Campoverde Reyes, Brooke Pfister, Kathryn Ackerman, Meghan Slattery, Katherine Cooper, Alexander Toth, Nupur Gupta, Mark Goldstein, Kamryn Eddy, Madhusmita Misra
BACKGROUND: Mechanical loading improves bone mineral density (BMD) and strength while decreasing fracture risk. Cross-sectional studies show that exercise advantage is lost in oligo-amenorrheic athletes (OA). Longitudinal studies examining the opposing effects of exercise and hypogonadism on bone are lacking in adolescents/young adults. OBJECTIVE: Evaluate differences in bone accrual over 12 months in OA, eumenorrheic athletes (EA) and non-athletes (NA). We hypothesized that bone accrual would be lower in OA than EA and NA, with differences most pronounced at non-weight bearing trabecular sites...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29718354/effectiveness-of-a-who-safe-childbirth-checklist-coaching-based-intervention-on-the-availability-of-essential-birth-supplies-in-uttar-pradesh-india
#5
Jenny J Maisonneuve, Katherine E A Semrau, Pinki Maji, Vinay Pratap Singh, Kate A Miller, Ian Solsky, Neeraj Dixit, Jigyasa Sharma, Janaka Lagoo, Natalie Panariello, Brandon Neal, Tapan Kalita, Nabihah Kara, Vishwajeet Kumar, Lisa R Hirschhorn
Objective: Evaluate the impact of a World Health Organization Safe Childbirth Checklist coaching-based intervention (BetterBirth Program) on availability and procurement of essential childbirth-related supplies. Design: Matched pair, cluster-randomized controlled trial. Setting: Uttar Pradesh, India. Participants: 120 government-sector health facilities (60 interventions, 60 controls). Supply-availability surveys were conducted quarterly in all sites...
April 30, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29687875/evaluation-of-thyroid-nodule-characteristics-in-subclinical-hypothyroid-patients-under-a-myo-inositol-plus-selenium-treatment
#6
M Nordio, S Basciani
OBJECTIVE: The anticancer effect of myo-inositol (MI) is catching researchers' attention worldwide. Thyroid nodules (TNs) have been detected by ultrasound (US) in up to 76% of the general population and, although most of them are benign, thyroid cancer is the most common malignancy of the endocrine system. PATIENTS AND METHODS: A retrospective, observational study was conducted in 642 patients with suspected hypothyroidism undergoing US. The analysis was addressed exclusively to patients with subclinical hypothyroidism (SCH) or thyroid-stimulating hormone (TSH) levels borderline associated to TNs classified as class I and II; 1 group (control, no...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29614608/-primary-prevention-by-hepatitis-b-vaccine-on-liver-cancer-in-high-incidence-area-of-china
#7
Y T Wang, T Y Chen, J Zhu, Y C Jiao, C F Qu
Objective: Incidence of primary liver cancer (PLC) in China is mostly related to chronic infection of hepatitis B virus (HBV). Qidong was one of the endemic areas with high incidence of PLC in China before 2000. We conducted a series of studies regarding on PLC etiological prevention during the past decades to develop better primary prevention strategies for PLC. Methods: Qidong Hepatitis B Intervention Study was conducted in 1983-1990. A total of 41 182 newborns were randomly assigned to vaccination group and 40 211 (97...
April 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29573330/clinically-relevant-bleeding-in-cancer-patients-treated-for-venous-thromboembolism-from-the-catch-study
#8
Pieter W Kamphuisen, Agnes Y Y Lee, Guy Meyer, Rupert Bauersachs, Mette S Janas, Mikala F Jarner, Alok A Khorana
BACKGROUND: Cancer patients with acute venous thromboembolism (VTE) receiving anticoagulant treatment have increased bleeding risk. OBJECTIVES: We performed a pre-specified secondary analysis of the randomized, open-label, Phase III CATCH trial (NCT01130025) to assess the rate, site and risk factors of clinically relevant bleeding (CRB). PATIENTS/METHODS: Patients with active cancer and acute, symptomatic VTE received either tinzaparin 175 IU/kg once daily or warfarin (target international normalized ratio [INR] 2...
March 24, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29540612/association-of-white-matter-hyperintensities-with-short-term-outcomes-in-patients-with-minor-cerebrovascular-events
#9
Charlotte Zerna, Amy Y X Yu, Jayesh Modi, Shiel K Patel, Jonathan I Coulter, Eric E Smith, Shelagh B Coutts
BACKGROUND AND PURPOSE: White matter lesions (WML) are associated with cognitive decline, increased stroke risk, and disability in old age. We hypothesized that superimposed acute cerebrovascular occlusion on chronic preexisting injury (leukoaraiosis) leads to worse outcome after minor cerebrovascular event, both using quantitative (volumetric) and qualitative (Fazekas scale) assessment, as well as relative total brain volume. METHODS: WML volume assessment was performed in 425 patients with high-risk transient ischemic attack (TIA; motor/speech deficits >5 minutes) or minor strokes from the CATCH study (CT and MRI in the Triage of TIA and Minor Cerebrovascular Events to Identify High Risk Patients)...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29536298/quality-and-quantity-of-biological-production-in-water-bodies-with-different-concentration-of-phosphorus-case-study-of-eurasian-perch
#10
M I Gladyshev
For the first time, the quantity of protectors of cardiovascular deceases-omega-3 polyunsaturated fatty acids, eicosapentaenoic (20:5n-3, EPA) and docosahexaenoic (22:6n-3, DHA), obtained through fish (Eurasian perch) catch in water bodies of different trophic status was determined. A formula was drawn to calculate the quantity of obtained EPA + DHA (kg km-2 year-1 ) depending on the concentration of total phosphorus in water. It is found that the maximum quantity of EPA + DHA can be obtained by humans from fish caught in mesotrophic water bodies...
January 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29507841/reproduction-and-community-structure-of-fish-from-winter-catch-sites-from-industrial-shrimp-bycatch-from-the-northeast-and-southeast-mexican-pacific
#11
Jorge de Jesus Tirado-Ibarra, Mariany Loya-Rodriguez, Jose Carlos Morales-Arevalo, Isabel Rosario Muñoz-Garcia, Francisco Martinez-Perez, Jorge Saul Ramirez-Perez, Laura Rebeca Jimenez-Gutierrez
The shrimp fishery is one of the most important fisheries in the world, although the low selectivity from trawling nets has led to the capture of a large number of non-target species. Shrimp-bycatch species include a large number of fish and invertebrate species, of which fish species are the most abundant. The present study aims to determine the community structure as well as the average sizes at first maturity of the fish species from shrimp-bycatch caught from industrial fisheries in the Mexican Pacific from Sinaloa to Guerrero, from January to March 2015...
2018: PeerJ
https://www.readbyqxmd.com/read/29425358/very-low-prevalence-of-vaccine-human-papillomavirus-types-among-18-to-35-year-old-australian-women-9-years-following-implementation-of-vaccination
#12
Dorothy A Machalek, Suzanne M Garland, Julia M L Brotherton, Deborah Bateson, Kathleen McNamee, Mary Stewart, S Rachel Skinner, Bette Liu, Alyssa M Cornall, John M Kaldor, Sepehr N Tabrizi
Introduction: A quadrivalent human papillomavirus vaccination program targeting females aged 12-13 years commenced in Australia in 2007, with catch-up vaccination of 14-26 year olds through 2009. We evaluated the program's impact on HPV prevalence among women aged 18-35 in 2015. Methods: HPV prevalence among women aged 18-24 and 25-35 was compared with prevalence in these age groups in 2005-2007. For women aged 18-24, we also compared prevalence with that in a postvaccine study conducted in 2010-2012...
April 23, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29411730/where-we-are-in-the-fight-against-hepatitis-b-infection-trends-in-hepatitis-b-virus-seroprevalence-in-black-sea-region-of-turkey
#13
F A Igde, H Taskin, M Igde, Z Yazici, A Atilla
CONTEXT: To determine new strategies for complete coverage of hepatitis B virus (HBV) vaccination, every country needs to take into concern factors of infection transmission in its own region. AIMS: The aim of this study was to investigate the seroprevalence of hepatitis B among all age groups in northern Turkey using HBsAg and anti-HBs serological markers. MATERIALS AND METHODS: The laboratory records of a total of 101648 patients of all ages attending a tertiary level hospital in Samsun, a Black Sea coastal city, between January 2014 and May 2016 were evaluated retrospectively...
January 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29382313/opsin-expression-patterns-coincide-with-photoreceptor-development-during-pupal-development-in-the-honey-bee-apis-mellifera
#14
Leonie Lichtenstein, Kornelia Grübel, Johannes Spaethe
BACKGROUND: The compound eyes of insects allow them to catch photons and convert the energy into electric signals. All compound eyes consist of numerous ommatidia, each comprising a fixed number of photoreceptors. Different ommatidial types are characterized by a specific set of photoreceptors differing in spectral sensitivity. In honey bees, males and females possess different ommatidial types forming distinct retinal mosaics. However, data are lacking on retinal ontogeny and the mechanisms by which the eyes are patterned...
January 30, 2018: BMC Developmental Biology
https://www.readbyqxmd.com/read/29316190/life-of-patients-10-years-after-a-successful-pediatric-intestinal-transplantation-in-europe
#15
Lorenzo Norsa, Girish Gupte, Esther Ramos Boluda, Francisca Joly, Olivier Corcos, Jacques Pirenne, Gustaf Herlenius, Florence Lacaille
A multicenter Europe-wide single-point study in intestinal transplantation (ITx) centers was conducted to identify and describe patients surviving for more than 10 years after ITx in childhood. The health and nutritional status, care requirements and psychosocial status were recorded. Among 120 transplanted before 2005, 38 patients with a functioning graft were included. Thirty (79%) had an exclusive oral diet, seven (18%) complimentary enteral nutrition for eating disorders, and one a combination of parenteral and enteral nutrition...
January 9, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29314175/somatic-diversification-of-the-b-cell-repertoire-requires-two-cell-subsets
#16
M Cohn
Evolution found itself in a Catch-22 situation when selecting for the somatically derived paratopic repertoire of the humoral immune system. The B cell BCR repertoire can only be somatically diversified from a substrate of paratopes that is encoded in the germline. In order for the cells expressing that substrate to also be a target of germline selection, their BCRs must, independently, be of selective value by being expressed in a functionally important way in each individual. A somatically derived repertoire scrambles this substrate so that its specificities are lost, making it unselectable in the germline...
March 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29297368/the-bloody-mess-of-red-blood-cell-transfusion
#17
REVIEW
Susilo Chandra, Hrishikesh Kulkarni, Martin Westphal
Red blood cell (RBC) transfusion might be life-saving in settings with acute blood loss, especially uncontrolled haemorrhagic shock. However, there appears to be a catch-22 situation reflected by the facts that preoperative anaemia represents an independent risk factor for postoperative morbidity and mortality, and that RBC transfusion might also contribute to adverse clinical outcomes. This dilemma is further complicated by the difficulty to define the "best" transfusion trigger and strategy. Since one size does obviously not fit all, a personalised approach is merited...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29241841/dorsal-wrist-plication-for-midcarpal-instability
#18
Herbert P von Schroeder
PURPOSE: Midcarpal instability (MCI) is a cause of chronic wrist pain for which treatment remains controversial. This study's purpose was to determine the outcome of a treatment algorithm for MCI that included immobilization and surgical interventions. METHODS: We prospectively enrolled 23 consecutive patients (12 males, average age 27 years) with 27 symptomatic wrists. All had generalized wrist pain with an average duration of 22 months. All had MCI and a catch-up clunk that reproduced the symptoms...
December 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29204224/bacteriology-and-antibiogram-of-urinary-tract-infection-among-female-patients-in-a-tertiary-health-facility-in-south-eastern-nigeria
#19
REVIEW
Angus N Oli, Vivian B Akabueze, Chijioke E Ezeudu, George U Eleje, Obiora S Ejiofor, Ifeanyichukwu U Ezebialu, Charlotte B Oguejiofor, Ifeoma M Ekejindu, George O Emechebe, Kenneth N Okeke
Background: Urinary Tract Infection (UTI) is a common contagion among men and women with the incidence relatively higher among women due to their differing anatomy. An understanding of the kind of pathogens implicated in urinary tract infections as well as antibiotic susceptibility profiling may help the clinician make rationally correct empirical choice in their treatment. Objective: This study is aimed at determining the type and antibiotic susceptibility pattern of bacterial uropathogens isolated from female patients attending Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH), Awka, Nigeria...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29178520/a-catch-22-interleukin-22-and-cancer
#20
REVIEW
Pedro Hernandez, Konrad Gronke, Andreas Diefenbach
Barrier surfaces of multicellular organisms are in constant contact with the environment and infractions to the integrity of epithelial surfaces is likely a frequent event. Interestingly, components of the immune system, that can be activated by environmental compounds such as the microbiota or nutrients, are interspersed among epithelial cells or directly underlie the epithelium. It is now appreciated that immune cells continuously receive and integrate signals from the environment. Curiously, such continuous reception of stimulation does not normally trigger an inflammatory response but mediators produced by immune cells in response to such signals seem to rather promote barrier integrity and repair...
January 2018: European Journal of Immunology
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