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https://www.readbyqxmd.com/read/27921330/the-new-face-of-isotopic-nmr-at-natural-abundance
#1
Tangi Jézéquel, Valentin Joubert, Patrick Giraudeau, Gérald S Remaud, Serge Akoka
The most widely used method for isotope analysis at natural abundance is isotope ratio monitoring by Mass Spectrometry (irm-MS) which provides bulk isotopic composition in (2) H, (13) C, (15) N, (18) O or (34) S. However, in the 1980s, the direct access to Site-specific Natural Isotope Fractionation by Nuclear Magnetic Resonance (SNIF-NMR(TM) ) was immediately recognized as a powerful technique to authenticate the origin of natural or synthetic products. The initial - and still most popular - application consisted in detecting the chaptalization of wines by irm-(2) H NMR...
November 7, 2016: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/27921291/evaluation-of-capillary-electrophoresis-for-the-analysis-of-rooibos-and-honeybush-tea-phenolics
#2
William J Arries, Andreas G J Tredoux, Dalene de Beer, Elizabeth Joubert, André de Villiers
Rooibos and honeybush are popular herbal teas produced from the shrubs of Aspalathus linearis and Cyclopia spp., respectively, which are indigenous to South Africa. Both herbal teas are rich in polyphenols and their consumption is associated with several health benefits, partly ascribed to their phenolic constituents. Quantification of phenolics in extracts and teas for quality control and research purposes is generally performed using HPLC, although dedicated and often species-specific methods are required...
December 6, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27905274/statistical-approaches-for-assessing-health-effects-of-environmental-chemical-mixtures-in-epidemiology-lessons-from-an-innovative-workshop
#3
Kyla W Taylor, Bonnie R Joubert, Joe M Braun, Caroline Dilworth, Chris Gennings, Russ Hauser, Jerry J Heindel, Cynthia V Rider, Thomas F Webster, Danielle J Carlin
No abstract text is available yet for this article.
December 1, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27897996/in-vitro-chemopreventive-properties-of-green-tea-rooibos-and-honeybush-extracts-in-skin-cells
#4
Tandeka U Magcwebeba, Pieter Swart, Sonja Swanevelder, Elizabeth Joubert, Wentzel C A Gelderblom
The chemopreventive properties of the herbal teas rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) have been demonstrated on mouse skin in vivo but the underlying mechanisms are not clear. The aim of the current study was to determine the anti-proliferative and pro-apoptotic activity of methanol and aqueous extracts of rooibos and two Cyclopia species in different skin cells, using green tea (Camellia sinensis) as a benchmark. Extracts were also characterised for their major individual polyphenols by high performance liquid chromatography and spectroscopically for the total polyphenol (TP) groups...
November 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27887572/maternal-smoking-impacts-key-biological-pathways-in-newborns-through-epigenetic-modification-in-utero
#5
Daniel M Rotroff, Bonnie R Joubert, Skylar W Marvel, Siri E Håberg, Michael C Wu, Roy M Nilsen, Per M Ueland, Wenche Nystad, Stephanie J London, Alison Motsinger-Reif
BACKGROUND: Children exposed to maternal smoking during pregnancy exhibit increased risk for many adverse health effects. Maternal smoking influences methylation in newborns at specific CpG sites (CpGs). Here, we extend evaluation of individual CpGs to gene-level and pathway-level analyses among 1062 participants in the Norwegian Mother and Child Cohort Study (MoBa) using the Illumina 450 K platform to measure methylation in newborn DNA and maternal smoking in pregnancy, assessed using the biomarker, plasma cotinine...
November 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27879282/sex-related-discordance-between-aortic-valve-calcification-and-hemodynamic-severity-of-aortic-stenosis-is-valvular-fibrosis-the-explanation
#6
Louis Simard, Nancy Côté, François Dagenais, Patrick Mathieu, Christian Couture, Sylvain Trahan, Yohan Bossé, Siamak Mohammadi, Sylvain Pagé, Philippe Joubert, Marie-Annick Clavel
RATIONALE: Calcific aortic stenosis (AS) is characterized by calcium deposition in valve leaflets. However, women present lower aortic valve calcification (AVC) loads than men for the same AS hemodynamic severity. OBJECTIVE: We thus aimed to assess sex-differences in aortic valve fibro-calcific remodelling. METHODS AND RESULTS: One hundred and twenty-five patients underwent Doppler-echocardiography and multidetector-computed-tomography within 3 months prior to aortic valve replacement...
November 22, 2016: Circulation Research
https://www.readbyqxmd.com/read/27871864/review-of-developmental-origins-of-health-and-disease-publications-in-environmental-epidemiology
#7
Jerrold J Heindel, Lesley A Skalla, Bonnie R Joubert, Caroline H Dilworth, Kimberly A Gray
The Developmental Origins of Health and Disease (DOHaD) scientific field investigates the influence of early life environmental stressors on later life health outcomes. Environmental chemical exposures are a particular focus area within this field. Although the DOHaD hypothesis originated in the 1990s, the data evaluating this hypothesis in environmental epidemiology has not been comprehensively summarized. We conducted a scoping literature review to describe the human evidence for the DOHaD hypothesis and to identify, 1) where there may be reasonable data to draw conclusions, and 2) areas warranting further research...
November 18, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27867119/glioblastoma-secondary-to-meningioma-a-case-report-and-literature-review
#8
Pauline Sahuc, Christophe Joubert, Anh-Tuan Nguyen, Bernard Fouet, Delphine Wybrecht, Anthony Faivre, Philippe Alla, Arnaud Dagain
BACKGROUND: The pathophysiologies underlying meningioma and glioma are quite distinct. The coexistence of those two lesions in a same patient is rare, and that at the same location is even more exceptional. CASE DESCRIPTION: We report a case of a 79-year-old man initially presenting a meningioma that was treated by complete excision of the lesion. The patient had two relapses at the same site in which glioblastoma was confirmed histopathologically. CONCLUSIONS: Glial transformation meningiomas remains a contentious issue, with coincidental occurrence being the most prevalent explanation...
November 17, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27866068/an-abnormal-ocular-motor-manifestation-of-joubert-syndrome
#9
Jeanie Ling, Viraj Mehta, Anvesh Reddy, Matthew Hollar, Sean Donahue
Joubert syndrome is a congenital neurodevelopmental disorder primarily affecting the midbrain and hindbrain. It is characterized by ataxia, hypotonia, and developmental delay as well as apnea or abnormal ocular motor function. We describe and present a video of a child with Joubert syndrome with an alternating skew deviation in primary position rather than on lateral gaze, which is a more characteristic phenotype of this condition.
November 16, 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27862526/systems-genetics-reveals-a-transcriptional-network-associated-with-susceptibility-in-the-maize-gray-leaf-spot-pathosystem
#10
Nanette Christie, Alexander A Myburg, Fourie Joubert, Shane L Murray, Maryke Carstens, Yao-Cheng Lin, Jacqueline Meyer, Bridget G Crampton, Shawn A Christensen, Jean F Ntuli, Sara S Wighard, Yves Van de Peer, Dave K Berger
We used a systems genetics approach to elucidate molecular mechanisms of maize responses to gray leaf spot (GLS) disease, caused by Cercospora zeina, a threat to maize production globally. Expression analysis of earleaf samples in a sub-tropical maize RIL population (CML444 X SC Malawi) subjected in field to C. zeina infection allowed detection of 20,206 expression QTLs (eQTL). Four trans-eQTL hotspots coincided with GLS disease QTLs mapped in the same field experiment. Co-expression network analysis identified three expression modules correlated with GLS disease scores...
November 12, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27855205/herbaceous-legume-encroachment-reduces-grass-productivity-and-density-in-arid-rangelands
#11
Thomas C Wagner, Susanne Hane, Dave F Joubert, Christina Fischer
Worldwide savannas and arid grasslands are mainly used for livestock grazing, providing livelihood to over a billion people. While normally dominated by perennial C4 grasses, these rangelands are increasingly affected by the massive spread of native, mainly woody legumes. The consequences are often a repression of grass cover and productivity, leading to a reduced carrying capacity. While such encroachment by woody plants has been extensively researched, studies on similar processes involving herbaceous species are rare...
2016: PloS One
https://www.readbyqxmd.com/read/27852419/returning-to-work-the-cancer-survivor-s-transformational-journey-of-adjustment-and-coping
#12
Antoni Barnard, Loraine Clur, Yvonne Joubert
The aim of this study was to explore cancer survivors' return to work (RTW) experience with a specific focus on the adjustment and coping process underlying their journey. The study was conducted in the Southern Cape, South Africa, with eight cancer survivors having returned to work following successful treatment of various types of cancer. Unstructured interviews were conducted and data were analysed following the principles of hermeneutic phenomenological reflection and analysis. Four themes emerged, representing the changing adjustment responses and coping during the RTW journey...
2016: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/27850205/565-nonclinical-factors-and-the-timing-of-decisions-to-withdraw-life-sustaining-treatment-in-adult-icus
#13
William Seligman, Paula Hutton, Margot Flint, Kaarkuzhali Krishnamurthy, Andrew Courtwright, Ivan Joubert, Nicholas Sadovnikoff, Stuart McKechnie
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847078/successful-treatment-of-esophageal-necrosis-secondary-to-acute-type-b-aortic-dissection
#14
Kyla D Joubert, Richard D Betzold, Matthew A Steliga
Esophageal necrosis after descending aortic dissection has been described but with no reports of successful treatment. A 66-year-old man with aortic dissection extending from the left subclavian artery through the common iliac arteries subsequently experienced esophageal necrosis. He underwent thoracic esophagectomy, cervical end esophagostomy, and open gastrostomy tube placement. Gastrointestinal continuity was established with a gastric tube conduit in the substernal plane. An oral diet was tolerated after reconstruction...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27845750/inhibitory-interactions-of-aspalathus-linearis-rooibos-extracts-and-compounds-aspalathin-and-z-2-%C3%AE-d-glucopyranosyloxy-3-phenylpropenoic-acid-on-cytochromes-metabolizing-hypoglycemic-and-hypolipidemic-drugs
#15
Oelfah Patel, Christo Muller, Elizabeth Joubert, Johan Louw, Bernd Rosenkranz, Charles Awortwe
Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the use of natural products are of increasing concern. Cytochrome P450 enzymes, CYP2C8, CYP2C9, and CYP3A4, are important in the metabolism of hypoglycemic drugs, such as thiazolidinediones (TZDs) and sulfonylureas, and hypocholesterolemic drugs, such as atorvastatin. This study investigated the effects of rooibos extracts, prepared from "unfermented" and "fermented" rooibos plant material and two of the major bioactive compounds, Z-2-(β-d-glucopyranosyloxy)-3-phenylpropenoic acid (PPAG) and aspalathin (ASP), on Vivid(®) recombinant CYP450 enzymes...
November 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27836634/visualization-of-aspergillus-fumigatus-biofilms-with-scanning-electron-microscopy-and-variable-pressure-scanning-electron-microscopy-a-comparison-of-processing-techniques
#16
Lydia-Marie Joubert, Jose Ag Ferreira, David A Stevens, Hasan Nazik, Lynette Cegelski
Aspergillus fumigatus biofilms consist of a three-dimensional network of cellular hyphae and extracellular matrix. They are involved in infections of immune-compromised individuals, particularly those with cystic fibrosis. These structures are associated with persistence of infection, resistance to host immunity, and antimicrobial resistance. Thorough understanding of structure and function is imperative in the design of therapeutic drugs. Optimization of processing parameters, including aldehyde fixation, heavy metal contrasting, drying techniques and Ionic Liquid treatment, was undertaken for an ultrastructural approach to understand cellular and extracellular biofilm components...
November 9, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27806731/in-vitro-assessment-of-a-computer-designed-potential-anticancer-agent-in-cervical-cancer-cells
#17
Michelle Helen Visagie, Seema Rummurat Jaiswal, Anna Margaretha Joubert
BACKGROUND: Computer-based technology is becoming increasingly essential in biological research where drug discovery programs start with the identification of suitable drug targets. 2-Methoxyestradiol (2ME2) is a 17β-estradiol metabolite that induces apoptosis in various cancer cell lines including cervical cancer, breast cancer and multiple myeloma. Owing to 2ME2's poor in vivo bioavailability, our laboratory in silico-designed and subsequently synthesized a novel 2ME2 analogue, 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol), using receptor- and ligand molecular modeling...
November 2, 2016: Biological Research
https://www.readbyqxmd.com/read/27785575/diagnosis-of-joubert-syndrome-via-ultrasonography
#18
Baris Buke, Emre Canverenler, Göksun İpek, Semiha Canverenler, Hatice Akkaya
Joubert syndrome (JS) and related disorders (JSRD) are a group of multiple congenital anomaly syndromes in which the diagnostic hallmark is the molar tooth sign (MTS), a complex midbrain malformation visible on brain imaging. Detection of the MTS should be followed by a diagnostic protocol to assess multi-organ involvement. The incidence of JSRD ranges between 1/80,000 and 1/100,000 live births, although these values may represent an underestimate. The neurological components of JSRD include hypotonia, ataxia, intellectual disability, abnormal eye movements, and neonatal breathing problems...
October 26, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27782105/two-novel-variants-in-cntnap1-in-two-siblings-presenting-with-congenital-hypotonia-and-hypomyelinating-neuropathy
#19
Mathilde Nizon, Benjamin Cogne, Jean-Michel Vallat, Madeleine Joubert, Jean-Michel Liet, Laure Simon, Marie Vincent, Sébastien Küry, Pierre Boisseau, Sébastien Schmitt, Sandra Mercier, Claire Bénéteau, Catherine Larrose, Marianne Coste, Xénia Latypova, Yann Péréon, Jean-Marie Mussini, Stéphane Bézieau, Bertrand Isidor
Homozygous frameshift variants in CNTNAP1 have recently been reported in patients with arthrogryposis and abnormal axon myelination. In two brothers with severe congenital hypotonia and foot deformities, we identified compound heterozygous variants in CNTNAP1, reporting the first causative missense variant, p.(Cys323Arg). Motor nerve conductions were markedly decreased. Nerve microscopical lesions confirmed a severe hypomyelinating process and showed loss of attachment sites of the myelin loops on the axons, which could be a characteristic of Caspr loss-of-function...
October 26, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27769583/-unilateral-maculopathy-in-a-young-male-patient-a-photic-laser-injury
#20
R Joubert, F Farguette, O Chevreaud, F Chiambaretta, E H Souied
We report the case of a twenty-year-old man with a unilateral maculopathy responsible for an acute visual acuity loss and a sudden absolute central scotoma. His schizoid personality made the medical history fruitless. The patient's best corrected visual acuity was 20/60. Clinical examination revealed a strictly unilateral maculopathy with pigment remodeling and hyper-autofluorescent areas. Through this case report, we describe the characteristics of the lesion and the pathway to the diagnosis: a laser pointer-induced photic injury...
October 18, 2016: Journal Français D'ophtalmologie
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