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https://www.readbyqxmd.com/read/28932735/attitude-to-human-papillomavirus-deoxyribonucleic-acid-based-cervical-cancer-screening-in-antenatal-care-in-nigeria-a-qualitative-study
#1
Temitope E Filade, Eileen O Dareng, Toyosi Olawande, Tolani A Fagbohun, Amos O Adebayo, Clement A Adebamowo
OBJECTIVES: Human papillomavirus (HPV) deoxyribonucleic acid (DNA)-based testing is increasingly used for cervical cancer screening in developed countries, but the best approach to utilizing it in low- and middle-income countries (LMIC) is unclear. Incorporation of HPV DNA-based testing into routine antenatal care (ANC) is a potential yet poorly explored strategy for cervical cancer screening in LMIC. We explored the attitude of health care workers and pregnant women to the incorporation of HPV DNA-based tests into routine ANC in Nigeria...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28931505/are-you-what-you-eat-or-what-your-mother-ate-or-both
#2
EDITORIAL
Stephen J Freedland
A high-fat high-sugar (HF-HS) diet promotes cancer development and progression. However, does the timing of diet matter? This is an important question with profound public health relevance. By exposing mice to a HF-HS diet either through feeding to a pregnant mother or nursing mother or after weaning and then chemically inducing breast cancer, the authors found the most crucial time for breast cancer risk was after weaning, while a HF-HS in utero diet actually slowed tumor development. Understanding early-life events provides valuable insight for later life events and proves it is never too early to start preventing disease...
September 20, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28928919/free-flap-transfer-reconstruction-in-managing-tongue-carcinoma-during-pregnancy
#3
Yuko Miyazaki, Kenji Fukuda, Kazutoshi Fujita, Soh Nishimoto, Tomonori Terada, Ryu Wada, Yohei Sotsuka, Kenichiro Kawai, Masao Kakibuchi
Malignant oral cancers do not commonly occur in pregnant women. But when they do, the presence of a foetus and maternal physiological changes complicate and limit the treatment options. Risk benefit assessment and balancing of them are always important. A 33-year-old woman, who was 25 weeks pregnant, presented with a squamous cell carcinoma on her tongue. She was clinically staged II (T2, N0 and M0). Discussions between the patient, surgical teams and obstetricians agreed to continue her pregnancy while managing the tumour...
August 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28911259/a-rare-case-of-ovarian-cancer-in-a-pregnant-woman-with-metastatic-non-small-cell-lung-cancer
#4
Esra Isci Bostanci, Ismail Guler, Ozlem Erdem, Cagatay Taskiran, M Anil Onan
No abstract text is available yet for this article.
September 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28906392/comparison-of-fertility-sparing-treatments-in-patients-with-early-endometrial-cancer-and-atypical-complex-hyperplasia-a-meta-analysis-and-systematic-review
#5
REVIEW
Jing Wei, Weiyuan Zhang, Limin Feng, Wanli Gao
BACKGROUND: There are some fertility-sparing treatments in patients with early endometrial cancer (EEC) or atypical complex hyperplasia (ACH), and the objective is to compare them by evaluating the oncologic and reproductive outcomes. METHODS: We searched the published literature using Medline, Cochrane, EMBASE, and Google Scholar databases up to January 3, 2017, with various combinations of keywords fertility-sparing treatments, progesterone, progestin, intrauterine devices, early endometrial cancer, and atypical complex hyperplasia...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28885416/reducing-false-positive-pregnancy-test-results-in-patients-with-cancer
#6
Samuel I McCash, Deborah J Goldfrank, Melissa S Pessin, Lakshmi V Ramanathan
OBJECTIVE: To assess whether the use of a laboratory test specific for intact human chorionic gonadotropin (hCG) would reduce the number of false-positive pregnancy test results. METHODS: From October 21, 2014, to January 20, 2015, and April 1, 2015, to June 2, 2015, all serum samples sent for pregnancy screening at a large cancer center with a value of 5 milli-international units/mL or greater total β-hCG were frozen and stored and then retested using intact hCG reagent...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28843262/cytological-features-associated-with-ureaplasma-urealyticum-in-pap-cervical-smear
#7
Mitsuaki Okodo, Jumpei Kawamura, Kaori Okayama, Kenji Kawai, Tadasi Fukui, Natsuko Shiina, Timothy Caniz, Hiromi Yabusaki, Masahiko Fujii
Purpose: Ureaplasma urealyticum is associated with several obstetric complications and increases the importance of risk management in pregnant women. Furthermore, U. urealyticum has been identified as a cofactor that interacts with human papillomavirus infection in cervical cancer onset. The aim of this study was to assess specific cytological features of U. urealyticum infection in Pap smears to determine whether additional microbiological testing should be performed for pregnant women with a high possibility of U...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28829623/radiation-risk-to-the-fluoroscopy-operator-and-staff
#8
REVIEW
Cosette M Stahl, Quinn C Meisinger, Michael P Andre, Thomas B Kinney, Isabel G Newton
OBJECTIVE: Recent articles discussing cases of brain cancer in interventionalists have raised concerns regarding the hazards of occupational exposure to ionizing radiation. We review the basics of radiation dose and the potential radiation effects, particularly as they pertain to the operator. Then we present the data regarding the risk of each type of radiation effect to the fluoroscopy operator and staff, with special attention on cancer induction, radiation-induced cataracts, and the pregnant operator...
October 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28827262/polymorphisms-of-the-stem-cell-marker-gene-cd133-are-associated-the-clinical-outcome-in-a-cohort-of-chinese-non-small-cell-lung-cancer-patients
#9
Qing-Feng Liu, Zhi-Fei Zhang, Guang-Jie Hou, Guang-Yu Yang, Yi He
OBJECTIVES: To evaluate the prognostic relevance of four functional single nucleotide polymorphisms (SNPs) in CD133 (rs2240688A>C, rs10022537T>A, rs7686732C>G, and rs3130C>T) on overall survival (OS) of non-small cell lung cancer (NSCLC) patients. DESIGN: Retrospective cohort study. SETTING: Department of General Surgery, in a general hospital, Henan Province, China. PARTICIPANTS: NSCLC patients aged ≥18 years, who were not receiving preoperative neoadjuvant therapies and had a blood sample available for genotyping, were eligible for inclusion...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28806962/oncofertility-in-patients-with-stage-i-epithelial-ovarian-cancer-fertility-sparing-surgery-in-young-women-of-reproductive-age
#10
Xuan Jiang, Jiaxin Yang, Mei Yu, Weimin Xie, Dongyan Cao, Ming Wu, Lingya Pan, Huifang Huang, Yan You, Keng Shen
BACKGROUND: Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). METHODS: Overall, 108 patients of reproductive age (≤ 40 years) diagnosed with stage I EOC who were treated at Peking Union Medical College Hospital between 1999 and 2013 were included in the study. The Kaplan-Meier model and Cox regression analyses were used for the survival analysis...
August 15, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28797766/pregnancy-outcomes-after-a-breast-cancer-diagnosis-a-systematic-review-and-meta-analysis
#11
REVIEW
Brigitte Gerstl, Elizabeth Sullivan, Angela Ives, Christobel Saunders, Handan Wand, Antoinette Anazodo
Improvements in local and systemic treatment, along with earlier diagnoses through breast awareness and screening, have led to increases in survival and a decline in breast cancer (BC) recurrence. To the best of our knowledge, no meta-analysis has yet focused on pregnancy outcomes after BC treatment. Hence, our research group explored the reproductive outcomes (pregnancy, miscarriage, termination of pregnancy, live births) after BC treatment. The Embase, MEDLINE, PubMed, and Scopus databases were searched. Studies were included that reported on pregnancy and reproductive outcomes after treatment of BC...
July 10, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28783055/usual-choline-intakes-are-associated-with-egg-and-protein-food-consumption-in-the-united-states
#12
Taylor C Wallace, Victor L Fulgoni
Choline is an essential nutrient with critical roles in several biological processes including neuronal development, cell signaling, nerve impulse transmission, and lipid transport and metabolism. The National Cancer Institute method was used to assess usual intakes of choline from foods according to data for participants enrolled in the National Health and Nutrition Examination Survey 2009-2014 datasets and pregnant women in the 2005-2014 datasets. Suboptimal intakes of choline are present across many gender and life-stage subpopulations, as well as pregnant women in the U...
August 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28780210/heavy-metals-lead-cadmium-methylmercury-arsenic-in-commonly-imported-rice-grains-oryza-sativa-sold-in-saudi-arabia-and-their-potential-health-risk
#13
Iman Al-Saleh, Mai Abduljabbar
The levels of heavy metals (lead, cadmium, methylmercury and arsenic) were determined in 37 brands of imported rice commonly consumed in Saudi Arabia after soaking and rinsing with water, and their potential health risks to residents were estimated by three indices: hazard quotient (HQ), hazard index (HI) and cancer risk (CR). The mean levels of lead, cadmium, methylmercury and total arsenic in soaked (rinsed) rice grains were 0.034 (0.057), 0.015 (0.027), 0.004 (0.007) and 0.202 (0.183) μg/g dry weight, respectively...
October 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28771777/high-risk-papillomavirus-infection-among-women-living-with-human-immunodeficiency-virus-brazilian-multicentric-study
#14
Angelica E Miranda, Mariangela F Silveira, Ana Gabriela Travassos, Teresinha Tenório, Isabel Cristina Chulvis do Val, Leonor de Lannoy, Hortensio Simões de Mattos Junior, Newton Sergio de Carvalho
BACKGROUND: Cervical cancer is an important health issue in Latin America. Although HPV infections can have spontaneous clearance, persistence of high-risk (HR) HPV is a risk factor for cervical cancer among women and it is even higher in HIV-infected women. OBJECTIVES: to determine the prevalence of HR-HPV and risk factors among HIV-infected women attending reference services for HIV/AIDS in different regions of Brazil. METHODS: Cross-sectional study conducted among HIV-infected women attended at referral care centers for HIV/AIDS in nine states of Brazil...
August 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28763018/maternal-immunization-new-perspectives-on-its-application-against-non-infectious-related-diseases-in-newborns
#15
REVIEW
Federica Riccardo, Aline Réal, Claudia Voena, Roberto Chiarle, Federica Cavallo, Giuseppina Barutello
The continuous evolution in preventive medicine has anointed vaccination a versatile, human-health improving tool, which has led to a steady decline in deaths in the developing world. Maternal immunization represents an incisive step forward for the field of vaccination as it provides protection against various life-threatening diseases in pregnant women and their children. A number of studies to improve prevention rates and expand protection against the largest possible number of infections are still in progress...
August 1, 2017: Vaccines
https://www.readbyqxmd.com/read/28760341/biological-effects-of-anti-rankl-antibody-administration-in-pregnant-mice-and-their-newborns
#16
Nobuaki Okamatsu, Nobuhiro Sakai, Akiko Karakawa, Naoka Kouyama, Yurie Sato, Katsunori Inagaki, Yuji Kiuchi, Katsuji Oguchi, Takako Negishi-Koga, Masamichi Takami
Denosumab, a fully human monoclonal antibody that neutralizes receptor activator of nuclear factor-κB ligand (RANKL) and blocks osteoclast differentiation, has received approval in Japan for use as an anti-resorptive drug for osteoporosis and skeletal-related events (SREs) in patients with solid cancer. Denosumab is contraindicated during pregnancy, though the effects of blocking RANKL activity on pregnant mothers and their newborns are unclear. We used mice to investigate the effects of an anti-RANKL antibody on maternal and newborn health...
September 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28756339/whole-body-mri-for-systemic-staging-of-breast-cancer-in-pregnant-women
#17
Fedro A Peccatori, Giovanni Codacci-Pisanelli, Maria Del Grande, Giovanna Scarfone, Fabio Zugni, Giuseppe Petralia
When breast cancer is diagnosed during pregnancy, treatment should be as close; as possible to what is used in non-pregnant patients. This requires accurate local and systemic staging: ultrasound (US) is used for local staging and allows adequate evaluation of the liver and pelvis, but chest and bones cannot be explored and imaging techniques involving exposure to ionizing radiation would be needed. However, since imaging techniques involving ionizing radiation and the use of radionuclides should be limited, whole body magnetic resonance imaging (WB-MRI) without administration of contrast agent represents a very interesting alternative, but limited data is available...
October 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28743530/different-inhibitory-potential-of-sex-hormones-on-nnk-detoxification-in%C3%A2-vitro-a-possible-explanation-for-gender-specific-lung-cancer-risk
#18
Claudia Stapelfeld, Karolina-Theresa Neumann, Edmund Maser
Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication step of this tobacco-specific carcinogen. It is mediated by different carbonyl reductases of the SDR (CBR1 and 11βHSD1) and AKR (AKR1B10, AKR1C1, AKR1C2 and AKR1C4) superfamilies. Inhibition constants of NNK reduction were determined with male (testosterone) and female (estradiol, progesterone) sex hormones and the contraceptives ethinylestradiol and drospirenone in A549 cells and with purified enzymes...
October 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28737125/taxanes-in-combination-with-platinum-derivatives-for-the-treatment-of-ovarian-cancer%C3%A2-during-pregnancy-a-literature-review%C3%A2
#19
Xiaoling Zheng, Yao Zhu, Yunchun Zhao, Shisen Feng, Caihong Zheng
Ovarian cancer is one of the most common types of solid carcinoma diagnosed during pregnancy. Taxane plus a platinum derivative is a combination therapy that is predominantly used in the treatment of ovarian cancer in non-pregnant women. Pregnancy adds various complexities to a course of treatment. In pregnant patients diagnosed with cancer during the first trimester, the risks of fetal malformations and fetal loss increase following the administration of cytotoxic drugs, and this is higher with multi-agent vs...
July 24, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28732002/-gastrointestinal-stromal-tumor-in-young-pregnant-woman-case-report
#20
Walker Del Cid Jove Oblitas, Miguel Joseph Abril Barreda
Female patient, 28 years old, with a gestation of 14 weeks, natural and from Ilo-Moquegua. Came with a time of disease 4 days with hematemesis, melena, epigastric pain and syncope. Background of colonic resection for peritonitis due to trauma 20 years ago; upper gastrointestinal bleeding three years ago; paternal grandparents died of gastric cancer; chronic gastritis diagnosed from 19 year old. In laboratory studies hemoglobin of 9.2. In the upper gastrointestinal endoscopy was found absence of active upper gastrointestinal bleeding, a large tumor in proximal body toward greater curvature and posterior wall, 8 cm in diameter approximately, lobed appearance, with most of the mucosal surface unscathed is evidence, areas of ulceration of 2-3 mm covered with fibrin (biopsies taken), hard consistency, tent sign (positive) and cushionsign (negative)...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
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