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https://www.readbyqxmd.com/read/29145270/study-on-the-adverse-effects-following-chemotherapy-for-breast-cancer-diagnosis-during-pregnancy-the-first-case-report-in-china
#1
Xin Ye, Qi He, Xiaoyun Zhou
RATIONALE: Treatment of breast cancer during pregnancy (BCP) remains a challenge to physicians. Surgery and chemotherapy during pregnancy are widely used for the treatment of BCP. Herein, we reported 3 Chinese patients with BCP who underwent chemotherapy during pregnancy and were followed up for adverse effects. PATIENT CONCERNS: Three female patients (case 1, case 2, and case 3) of 37-, 32-, and 28-year-old with breast masses were enrolled. Case 1 had been pregnant for over 4 months, case 2 over 7 months, and case 3 for 7 months...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29122355/current-status-of-organochlorine-pesticides-ocps-and-polychlorinated-biphenyls-pcbs-exposure-among-mothers-and-their-babies-of-korea-check-cohort-study
#2
Sooran Choi, Hai-Joong Kim, Sunmi Kim, Gyuyeon Choi, Sungjoo Kim, Jeongim Park, Soon-Sup Shim, Inae Lee, Sungkyoon Kim, Hyo-Bang Moon, Kyungho Choi, Jeong Jae Lee, Su Young Kim
Despite the global ban, organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) have been a persistent and significant environmental health issue worldwide. Prenatal exposure to these persistent organic pollutants (POPs) has been identified as a major route of exposure among developing fetuses and newborn infants. Among Children's Health and Environmental Health of Korea (CHECK) cohort population, pregnant females (n=148) and their matching newborn infants (n=117) recruited from four cities of Korea in 2011 were investigated...
November 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29119083/awareness-of-health-effects-of-exposure-to-secondhand-smoke-from-cigarettes-a-cross-sectional-study-of-never-smoked-adult-primary-care-patients-in-eastern-nigeria
#3
Gabriel Uche Pascal Iloh, Peace Ifeoma Collins
Background: Cigarette smoking whether actively or passively is a growing public health problem. Despite the wealth of information on the hazards of active cigarette smoking, awareness of the health effects of passive smoking on human population is often neglected in Nigeria. Aim: The study was aimed at describing the awareness of health effects of exposure to secondhand smoke from cigarettes among never-smoked adult primary care patients in Eastern Nigeria. Materials and Methods: A hospital-based study carried out on a cross-section of 500 adult patients in a primary care clinic in Nigeria...
October 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29111146/medical-contraindications-to-estrogen-and-contraceptive-use-among-women-veterans
#4
Colleen P Judge, Xinhua Zhao, Florentina E Sileanu, Maria K Mor, Sonya Borrero
BACKGROUND: Women veterans have high rates of medical comorbidities and may be particularly vulnerable to adverse health outcomes associated with unintended pregnancy. OBJECTIVES: The objective of the study was to estimate the prevalence of medical contraindications to estrogen-containing combined hormonal contraception among women veterans of reproductive age and to evaluate the relationship between contraindications and contraceptive use. STUDY DESIGN: This was a secondary analysis of data from a cross-sectional, telephone-based survey with a national sample of 2302 female veterans, aged 18-45 years, who use the Veterans Administration Healthcare System for primary care...
October 27, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29109696/low-dose-alkylphenol-exposure-promotes-mammary-epithelium-alterations-and-transgenerational-developmental-defects-but-does-not-enhance-tumorigenic-behavior-of-breast-cancer-cells
#5
Clémence Chamard-Jovenin, Charlène Thiebaut, Amand Chesnel, Emmanuel Bresso, Chloé Morel, Malika Smail-Tabbone, Marie-Dominique Devignes, Taha Boukhobza, Hélène Dumond
Fetal and neonatal exposure to long-chain alkylphenols has been suspected to promote breast developmental disorders and consequently to increase breast cancer risk. However, disease predisposition from developmental exposures remains unclear. In this work, human MCF-10A mammary epithelial cells were exposed in vitro to a low dose of a realistic (4-nonylphenol + 4-tert-octylphenol) mixture. Transcriptome and cell-phenotype analyses combined to functional and signaling network modeling indicated that long-chain alkylphenols triggered enhanced proliferation, migration ability, and apoptosis resistance and shed light on the underlying molecular mechanisms which involved the human estrogen receptor alpha 36 (ERα36) variant...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29102433/effect-of-vitamin-d-supplementation-on-non-skeletal-disorders-a-systematic-review-of-meta-analyses-and-randomised-trials
#6
REVIEW
Philippe Autier, Patrick Mullie, Alina Macacu, Miruna Dragomir, Magali Boniol, Kim Coppens, Cécile Pizot, Mathieu Boniol
Randomised trials reported up to Dec 31, 2012, did not confirm that vitamin D supplementation could protect from non-skeletal health conditions affecting adults, as was expected on the basis of data from observational studies. To examine whether the more recently published meta-analyses and trials would change past conclusions, we systematically reviewed meta-analyses of vitamin D supplementation and non-skeletal disorders published between Jan 1, 2013, and May 31, 2017, that included study participants of all ages, including pregnant women...
October 25, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29100547/efficient-generation-of-p53-biallelic-knockout-diannan-miniature-pigs-via-talens-and-somatic-cell-nuclear-transfer
#7
Youfeng Shen, Kaixiang Xu, Zaimei Yuan, Jianxiong Guo, Heng Zhao, Xuezeng Zhang, Lu Zhao, Yubo Qing, Honghui Li, Weirong Pan, Baoyu Jia, Hong-Ye Zhao, Hong-Jiang Wei
BACKGROUND: Pigs have many features that make them attractive as biomedical models for various diseases, including cancer. P53 is an important tumor suppressor gene that exerts a central role in protecting cells from oncogenic transformation and is mutated in a large number of human cancers. P53 mutations occur in almost every type of tumor and in over 50% of all tumors. In a recent publication, pigs with a mutated P53 gene were generated that resulted in lymphoma and renal and osteogenic tumors...
November 3, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29070997/recurrence-of-ovarian-cancer-with-placental-metastasis-a-case-report
#8
Michiko Honda, Manabu Yamada, Toshio Kumasaka, Taiki Samejima, Hirohisa Satoh, Mitsuhiro Sugimoto
A 39-year-old primiparous Japanese female was admitted to the obstetrical emergency department of our hospital because of respiratory distress resulting from a large amount of pleural effusion, soon after a caesarean delivery (CD) at another hospital. While she was undergoing the CD, a giant ovarian tumour was identified. However, the tumour could not be removed at that facility and she was transferred to our hospital. Three days after the CD, a left salpingo-oophorectomy was performed with the purpose of controlling pleural and peritoneal effusions...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29050014/a-real-life-analysis-of-reproductive-outcome-after-fertility-preservation-in-female-cancer-patients
#9
Sofie Hulsbosch, Martin Koskas, Carla Tomassetti, Petra De Sutter, Hans Wildiers, Patrick Neven, Thomas D'Hooghe, Frederic Amant
BACKGROUND: Fertility preservation before or during cancer treatment in young women has become an important health issue because of delayed motherhood and improved survival rates. This study evaluates the necessity and the efficacy of fertility preservation, with a focus on actual pregnancy wish and outcome after fertility preservation and cancer treatment. PATIENTS AND METHODS: All consecutive patients who received fertility preservation in 2 university referral centers before or during cancer treatment were included...
October 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29045667/survey-of-reproductive-experiences-and-outcomes-of-cancer-survivors-who-stored-reproductive-material-before-treatment
#10
K Hammarberg, M Kirkman, C Stern, R I McLachlan, G Clarke, F Agresta, D Gook, L Rombauts, B Vollenhoven, J R W Fishe
STUDY QUESTION: What are the reproductive experiences and outcomes of people who store reproductive material before cancer treatment? SUMMARY ANSWER: Of respondents who had tried to achieve pregnancy since completing cancer treatment almost all had succeeded, in most cases through natural conception. WHAT IS KNOWN ALREADY: People of reproductive age who are diagnosed with cancer can cryopreserve reproductive material to guard against the adverse effects on fertility of gonadotoxic treatment...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040257/current-challenges-in-the-management-of-essential-thrombocythemia
#11
Ariel Kleman, Arun K Singavi, Laura C Michaelis
Essential thrombocythemia (ET), an uncommon blood cancer, is one of the classic myeloproliferative neoplasms, a category that also includes polycythemia vera and primary myelofibrosis. All 3 diseases are clonal hematopoietic stem cell disorders. Since 2005, when scientists discovered a molecular aberration driving clonal hematopoiesis in polycythemia vera, our understanding of the genomic underpinnings of these conditions has increased rapidly. Over the last decades, primary prevention of thrombotic and hemorrhagic complications has improved the lives of patients with ET, and the ability to characterize the disease by the presence or absence of molecular mutations has lent precision to our prognostic models...
October 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29022007/is-uterine-preservation-combined-with-bilateral-salpingo-oophorectomy-to-promote-subsequent-fertility-safe-in-infiltrative-mucinous-ovarian-cancer
#12
Sebastien Gouy, Marine Saidani, Amandine Maulard, Matthieu Faron, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
According to the latest World Health Organization classification (2014), mucinous ovarian cancers should be classified histologically as being either expansile or infiltrative. Compared to other epithelial cancers, both of these mucinous patterns are diagnosed, in the main, at an early stage, although they can affect relatively young patients. The infiltrative subtype is characterized by a morphologically and clinically more aggressive disease versus the expansile form. Consequently, even in young patients who would prefer fertility sparing management, the removal of both ovaries (even for a unilateral tumor) remains a common recommendation...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29020927/dilemmas-in-a-pregnant-woman-with-myelofibrosis-secondary-to-signet-ring-adenocarcinoma-a-case-report
#13
Pujun Guan, Zihang Chen, Li Zhang, Ling Pan
BACKGROUND: We describe the first reported case of myelofibrosis as an extremely rare complication of gastric cancer during pregnancy; the clinical diagnosis and treatment of which is highly challenging due to nonspecific symptoms coupled with the conflicting needs of immediate disease control and continuation of pregnancy. CASE PRESENTATION: We report a 36-year-old pregnant woman who presented with cytopenia, fatigue, vomiting, and diarrhea for 20 days on the background of newly diagnosed myelofibrosis secondary to gastric signet ring adenocarcinoma...
October 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28982650/incidental-detection-of-maternal-neoplasia-in-noninvasive-prenatal-testing
#14
Nilesh G Dharajiya, Daniel S Grosu, Daniel H Farkas, Ron M McCullough, Eyad Almasri, Youting Sun, Sung K Kim, Taylor J Jensen, Juan-Sebastian Saldivar, Eric J Topol, Dirk van den Boom, Mathias Ehrich
BACKGROUND: Noninvasive prenatal testing (NIPT) uses cell-free DNA (cfDNA)(5) as an analyte to detect copy-number alterations in the fetal genome. Because maternal and fetal cfDNA contributions are comingled, changes in the maternal genome can manifest as abnormal NIPT results. Circulating tumor DNA (ctDNA) present in cases of maternal neoplasia has the potential to distort the NIPT readout to a degree that prevents interpretation, resulting in a nonreportable test result for fetal aneuploidy...
October 5, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28974857/a-phantom-study-on-fetal-dose-reducing-factors-in-pregnant-patients-with-breast-cancer-during-radiotherapy-treatment
#15
Akın Öğretici, Aydın Çakır, Uğur Akbaş, Canan Köksal, Ümmühan Kalafat, Makbule Tambaş, Hatice Bilge
PURPOSE: This study aims to investigate the factors that reduce fetal dose in pregnant patients with breast cancer throughout their radiation treatment. Two main factors in a standard radiation oncology center are considered as the treatment planning systems (TPSs) and simple shielding for intensity modulated radiation therapy technique. MATERIALS AND METHODS: TPS factor was evaluated with two different planning algorithms: Anisotropic analytical algorithm and Acuros XB (external beam)...
July 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28974483/assessing-the-national-cancer-institute-s-smokefreemom-text-messaging-program-for-pregnant-smokers-pilot-randomized-trial
#16
Lorien C Abroms, Shawn Chiang, Laura Macherelli, Leah Leavitt, Margaret Montgomery
BACKGROUND: Automated text messages on mobile phones have been found to be effective for smoking cessation in adult smokers. OBJECTIVE: This study aims to test the acceptability and feasibility of SmokefreeMOM, a national smoking cessation text-messaging program for pregnant smokers. METHODS: Participants were recruited from prenatal care and randomized to receive SmokefreeMOM (n=55), an automated smoking cessation text-messaging program, or a control text message quitline referral (n=44)...
October 3, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28973702/treatment-of-the-pregnant-patient-with-breast-cancer
#17
REVIEW
Michael R Shafique, Marie Catherine Lee, Hyo Sook Han
Pregnancy-associated breast cancer is defined as invasive breast cancer diagnosed during gestation, within 1 year postpartum, or during lactation. Of particular interest is the treatment of invasive breast cancer during gestation; standard treatment protocols must take into account the health of the fetus. This article reviews the literature and emerging data regarding the treatment of pregnancy-associated breast cancer. Existing staging and treatment practices need slight modification in the setting of pregnancy...
October 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28973345/third-trimester-estrogens-and-maternal-breast-cancer-prospective-evidence
#18
Barbara A Cohn, Piera M Cirillo, Bill R Hopper, Pentti K Siiteri
Context: Full-term pregnancy is associated with a transient increase and life-time decrease in maternal breast cancer risk. Estrone (E1), estradiol (E2), and estriol (E3) are in high concentration during the third trimester. E1 and E2 metabolism produces carcinogenic intermediaries, and E3 metabolism does not. Objective: We tested the hypothesis that higher E3 in pregnancy is protective while higher E1 plus E2 increases risk. Design: Prospective case-cohort study (n = 620; 204 cases) nested in a 38-year follow-up of 15,528 pregnant women in the Child Health and Development Studies...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28969881/roles-of-endogenous-retroviruses-in-early-life-events
#19
Gkikas Magiorkinis, Aris Katzourakis, Pagona Lagiou
A retrovirus that infected our ancestors 100 million years ago became a human gene that is expressed in embryos and cancers, and can be detected in the blood of pregnant women. Accumulating evidence suggests potential roles for endogenous retroviruses in early life events, which may affect adult health.
November 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28954490/decreased-nk-cell-activity-after-partial-vulvectomy-in-pregnant-patient-with-vulvar-intraepithelial-neoplasia-3-vin3
#20
Malgorzata Jerzak, Andrzej Nowakowski, Monika Ohams, Andrzej Górski, Włodzimierz Baranowsk
INTRODUCTION AND OBJECTIVE: The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3). MATERIAL AND METHODS: NK cell and T reg activity in the study patient were analysed using flow cytometry. RESULTS: Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome. CONCLUSIONS: Although vulvar cancer may influence immune cell activity, this issue merits further study...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
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