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Paul Young

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https://www.readbyqxmd.com/read/29779140/knee-motion-symmetry-was-not-restored-in-patients-with-unilateral-bi-cruciate-retaining-total-knee-arthroplasty-in-vivo-three-dimensional-kinematic-analysis
#1
Paul Arauz, Yun Peng, Young-Min Kwon
PURPOSE: Although unilateral total knee arthroplasty (TKA) is successful in restoring function, there are concerns in relation to asymmetric gait patterns. Bi-cruciate retaining (BCR) TKA design preserves both anterior and posterior cruciate ligaments with the potential to restore normal joint kinematics. The purpose of this study was to investigate the in vivo three-dimensional (3D) kinematics of the knee in unilateral BCR TKA patients during gait. METHODS: Twenty-nine unilateral BCR TKA patients were evaluated for both knees during treadmill gait using a combined computer tomography and dual fluoroscopic imaging system approach...
May 19, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29778738/risk-adapted-therapy-for-young-children-with-medulloblastoma-sjyc07-therapeutic-and-molecular-outcomes-from-a-multicentre-phase-2-trial
#2
Giles W Robinson, Vasilisa A Rudneva, Ivo Buchhalter, Catherine A Billups, Sebastian M Waszak, Kyle S Smith, Daniel C Bowers, Anne Bendel, Paul G Fisher, Sonia Partap, John R Crawford, Tim Hassall, Daniel J Indelicato, Frederick Boop, Paul Klimo, Noah D Sabin, Zoltan Patay, Thomas E Merchant, Clinton F Stewart, Brent A Orr, Jan O Korbel, David T W Jones, Tanvi Sharma, Peter Lichter, Marcel Kool, Andrey Korshunov, Stefan M Pfister, Richard J Gilbertson, Robert P Sanders, Arzu Onar-Thomas, David W Ellison, Amar Gajjar, Paul A Northcott
BACKGROUND: Young children with medulloblastoma have a poor overall survival compared with older children, due to use of radiation-sparing therapy in young children. Radiotherapy is omitted or reduced in these young patients to spare them from debilitating long-term side-effects. We aimed to estimate event-free survival and define the molecular characteristics associated with progression-free survival in young patients with medulloblastoma using a risk-stratified treatment strategy designed to defer, reduce, or delay radiation exposure...
May 16, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29778606/avatrombopag-before-procedures-reduces-need-for-platelet-transfusion-in-patients-with-chronic-liver-disease-and-thrombocytopenia
#3
Norah Terrault, Yi-Cheng Chen, Namiki Izumi, Zeid Kayali, Paul Mitrut, Won Young Tak, Lee F Allen, Tarek Hassanein
BACKGROUND & AIMS: Patients with thrombocytopenia and chronic liver disease (CLD) may require platelet transfusions before scheduled procedures to decrease risk of bleeding. We performed 2 randomized, placebo-controlled, phase 3 trials in patients with thrombocytopenia and CLD undergoing scheduled procedures to evaluate the safety and efficacy of avatrombopag in increasing platelet counts in this patient population METHODS: In the ADAPT-1 and ADAPT-2 studies, adults with thrombocytopenia and CLD (n=231 and n= 204, respectively) were in 1 of 2 cohorts according to their baseline platelet count (below 40x109 /L or 40-50x109 /L) and within each cohort randomized (2:1) to 5 daily doses of avatrombopag (60 mg if baseline platelet count below 40x109 /L or 40 mg if 40-50x109 /L) or placebo...
May 17, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29777364/cell-division-and-turgor-mediate-enhanced-plant-growth-in-arabidopsis-plants-treated-with-the-bacterial-signalling-molecule-lumichrome
#4
Motlalepula Pholo, Beatrix Coetzee, Hans J Maree, Philip R Young, James R Lloyd, Jens Kossmann, Paul N Hills
Transcriptomic analysis indicates that the bacterial signalling molecule lumichrome enhances plant growth through a combination of enhanced cell division and cell enlargement, and possibly enhances photosynthesis. Lumichrome (7,8 dimethylalloxazine), a novel multitrophic signal molecule produced by Sinorhizobium meliloti bacteria, has previously been shown to elicit growth promotion in different plant species (Phillips et al. in Proc Natl Acad Sci USA 96:12275-12280, https://doi.org/10.1073/pnas.96.22.12275 , 1999)...
May 17, 2018: Planta
https://www.readbyqxmd.com/read/29776814/metallosis-in-cemented-titanium-alloy-total-knee-arthroplasty-without-apparent-metal-on-metal-articulation
#5
James Ho, John Mahajan, Martin Taylor, Ashlyn Byers, Paul Arauz, Young-Min Kwon
BACKGROUND: Metallosis is an uncommon phenomenon observed in late failures of cemented total knee arthroplasty (TKA), and it is rarely seen in the absence of metal-on-metal articulation. METHODS: We report the case of a TKA patient with cemented titanium-alloy components and a polyethylene patella that was revised for early loosening with intra-operative severe metallosis. RESULTS: We found that loosening and severe metallosis were associated with methacrylate particle abrasion on titanium alloy surfaces...
May 16, 2018: Knee
https://www.readbyqxmd.com/read/29776718/high-urinary-ferritin-reflects-myoglobin-iron-evacuation-in-dmd-patients
#6
Jérémy Rouillon, Thibaud Lefebvre, Jérôme Denard, Vincent Puy, Raed Daher, Jérôme Ausseil, Aleksandar Zocevic, Paul Fogel, Katell Peoc'h, Brenda Wong, Laurent Servais, Thomas Voit, Herve Puy, Zoubida Karim, Fedor Svinartchouk
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the dystrophin gene leading to the absence of the normal dystrophin protein. The efforts of many laboratories brought new treatments of DMD to the reality, but ongoing and forthcoming clinical trials suffer from absence of valuable biomarkers permitting to follow the outcome of the treatment day by day and to adjust the treatment if needed. In the present study the levels of 128 urinary proteins including growth factors, cytokines and chemokines were compared in urine of DMD patients and age related control subjects by antibody array approach...
March 20, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29775997/improved-acmg-compliant-in-silico-prediction-of-pathogenicity-for-missense-substitutions-encoded-by-tp53-variants
#7
Cristina Fortuno, Paul A James, Erin L Young, Bing Feng, Magali Olivier, Tina Pesaran, Sean V Tavtigian, Amanda B Spurdle
Clinical interpretation of germline missense variants represents a major challenge, including those in the TP53 Li-Fraumeni syndrome gene. Bioinformatic prediction is a key part of variant classification strategies. We aimed to optimize the performance of the Align-GVGD tool used for p53 missense variant prediction, and compare its performance to other bioinformatic tools (SIFT, PolyPhen-2) and ensemble methods (REVEL, BayesDel). Reference sets of assumed pathogenic and assumed benign variants were defined using functional and/or clinical data...
May 18, 2018: Human Mutation
https://www.readbyqxmd.com/read/29774242/balancing-charge-carrier-transport-in-a-quantum-dot-p-n-junction-toward-hysteresis-free-high-performance-solar-cells
#8
Yuljae Cho, Bo Hou, Jongchul Lim, Sanghyo Lee, Sangyeon Pak, John Hong, Paul Giraud, A-Rang Jang, Young-Woo Lee, Juwon Lee, Jae Eun Jang, Henry J Snaith, Stephen M Morris, Jung Inn Sohn, SeungNam Cha, Jong Min Kim
In a quantum dot solar cell (QDSC) that has an inverted structure, the QD layers form two different junctions between the electron transport layer (ETL) and the other semiconducting QD layer. Recent work on an inverted-structure QDSC has revealed that the junction between the QD layers is the dominant junction, rather than the junction between the ETL and the QD layers, which is in contrast to the conventional wisdom. However, to date, there have been a lack of systematic studies on the role and importance of the QD heterojunction structure on the behavior of the solar cell and the resulting device performance...
April 13, 2018: ACS Energy Letters
https://www.readbyqxmd.com/read/29771818/suppressed-acoustic-startle-response-in-traumatic-brain-injury-masks-post-traumatic-stress-disorder-hyper-responsivity
#9
Grant M Liska, Jea-Young Lee, Kaya Xu, Paul R Sanberg, Cesario V Borlongan
An exaggerated acoustic startle reflex (ASR) is a clinical indicator of anxiety disorders, such as post-traumatic stress disorder (PTSD). Given the prevalence of PTSD following traumatic brain injury (TBI), we studied the effects of TBI on ASR. Adult Sprague Dawley rats exposed to moderate controlled cortical impact injury model of TBI displayed suppression of ASR intensity and sensitivity. As patients with PTSD have been shown to display hyperactive startle responses, the present discrepant observation of TBI-induced suppression of ASR has clinical implications, in that the reduced, instead of elevated, startle response in patients with comorbid TBI/PTSD could be owing to a masking effect of TBI...
May 16, 2018: Neuroreport
https://www.readbyqxmd.com/read/29770569/frontal-cortical-thickness-correlates-positively-with-impulsivity-in-early-psychosis-male-patients
#10
Philipp S Baumann, Paul Klauser, Alessandra Griffa, Philippe Golay, Julie Palix, Luis Alameda, Valérie Moulin, Patric Hagmann, Kim Q Do, Philippe Conus
AIM: Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophrenia have been poorly investigated especially in young adults, the aim of this study was to investigate the relationship between impulsivity and cortical thickness in early psychosis (EP) patients. METHOD: A total of 17 male subjects in the early phase of psychosis were recruited...
May 17, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29764878/association-between-an-individual-housing-based-socioeconomic-index-and-inconsistent-self-reporting-of-health-conditions-a-prospective-cohort-study-in-the-mayo-clinic-biobank
#11
Euijung Ryu, Janet E Olson, Young J Juhn, Matthew A Hathcock, Chung-Il Wi, James R Cerhan, Kathleen J Yost, Paul Y Takahashi
OBJECTIVE: Using surveys to collect self-reported information on health and disease is commonly used in clinical practice and epidemiological research. However, the inconsistency of self-reported information collected longitudinally in repeated surveys is not well investigated. We aimed to investigate whether a socioeconomic status based on current housing characteristics, HOUsing-based SocioEconomic Status (HOUSES) index linking current address information to real estate property data, is associated with inconsistent self-reporting...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29764441/case-report-identification-of-an-hnf1b-p-arg527gln-mutation-in-a-maltese-patient-with-atypical-early-onset-diabetes-and-diabetic-nephropathy
#12
Nikolai Paul Pace, Johann Craus, Alex Felice, Josanne Vassallo
BACKGROUND: The diagnosis of atypical non-autoimmune forms of diabetes mellitus, such as maturity onset diabetes of the young (MODY) presents several challenges, in view of the extensive clinical and genetic heterogeneity of the disease. In this report we describe a case of atypical non autoimmune diabetes associated with a damaging HNF1β mutation. This is distinguished by a number of uncharacteristic clinical features, including early-onset obesity, the absence of renal cysts and diabetic nephropathy...
May 15, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29763774/precisely-controlled-delivery-of-magnesium-ions-thru-sponge-like-monodisperse-plga-nano-mgo-alginate-core-shell-microsphere-device-to-enable-in-situ-bone-regeneration
#13
Zhengjie Lin, Jun Wu, Wei Qiao, Ying Zhao, Karen H M Wong, Paul K Chu, Liming Bian, Shuilin Wu, Yufeng Zheng, Kenneth M C Cheung, Frankie Leung, Kelvin W K Yeung
A range of magnesium ions (Mg2+ ) used has demonstrated osteogenic tendency in vitro. Hence, we propose to actualize this concept by designing a new system to precisely control the Mg2+ delivery at a particular concentration in vivo in order to effectively stimulate in-situ bone regeneration. To achieve this objective, a monodisperse core-shell microsphere delivery system comprising of poly (lactic-co-glycolic acid) (PLGA) biopolymer, alginate hydrogel, and magnesium oxide nano-particles has been designed by using customized microfluidic capillary device...
May 8, 2018: Biomaterials
https://www.readbyqxmd.com/read/29762933/ross-procedure-following-a-dislodged-transcatheter-aortic-valve-replacement
#14
Samuel R Schnittman, Aaron J Weiss, Robin Varghese, Paul Stelzer
A 36-year-old pregnant woman with a history of rheumatic heart disease and prior aortic valve replacement and mitral valve repair presented to an outside hospital with severe aortic stenosis. The patient had a cardiac arrest upon labor induction and underwent a transcatheter aortic valve replacement (TAVR), which dislodged two days later. Five months later, the patient underwent removal of the dislodged TAVR and a Ross procedure at the authors' institution. The patient was stable upon discharge, with minimal aortic and pulmonary regurgitation...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29762525/electronic-magnetic-half-metallic-and-mechanical-properties-of-a-new-equiatomic-quaternary-heusler-compound-yrhtige-a-first-principles-study
#15
Yilin Han, Yang Wu, Tingzhou Li, R Khenata, Tie Yang, Xiaotian Wang
We apply First-principles theory to study the electronic structure as well as the magnetic and mechanical characteristics of YRhTiGe, a newly-designed Y-based quaternary equiatomic Heusler compound. This compound is half-metallic in nature with a ferromagnetic ground state. The total magnetic moment of YRhTiGe is 2 μB and it obeys the Slater-Pauling rule, Mt = Zt - 18, where Mt and Zt are the total magnetic moment and total number of valence electrons, respectively. The magnetic and half-metallic behaviors at its equilibrium and strained lattice constants have been discussed in detail...
May 15, 2018: Materials
https://www.readbyqxmd.com/read/29762520/condom-and-substance-use-at-last-sex-differences-between-msmo-and-mswo-high-school-youth
#16
Gregory Phillips, Mariah M Kalmin, Blair Turner, Dylan Felt, Rachel Marro, Paul Salamanca, Lauren B Beach
HIV disproportionately impacts youth, particularly young men who have sex with men (YMSM), a population that includes subgroups of young men who have sex with men only (YMSMO) and young men who have sex with men and women (YMSMW). In 2015, among male youth, 92% of new HIV diagnoses were among YMSM. The reasons why YMSM are disproportionately at risk for HIV acquisition, however, remain incompletely explored. We performed event-level analyses to compare how the frequency of condom use, drug and/or alcohol use at last sex differed among YMSMO and YMSWO (young men who have sex with women only) over a ten-year period from 2005⁻2015 within the Youth Risk Behavior Survey (YRBS)...
May 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29762500/circulating-micrornas-in-young-patients-with-acute-coronary-syndrome
#17
Kind-Leng Tong, Ahmad Syadi Mahmood Zuhdi, Wan Azman Wan Ahmad, Paul M Vanhoutte, Joao Pedro de Magalhaes, Mohd Rais Mustafa, Pooi-Fong Wong
Circulating microRNAs (miRNAs) hold great potential as novel diagnostic markers for acute coronary syndrome (ACS). This study sought to identify plasma miRNAs that are differentially expressed in young ACS patients (mean age of 38.5 ± 4.3 years) and evaluate their diagnostic potentials. Small RNA sequencing (sRNA-seq) was used to profile plasma miRNAs. Discriminatory power of the miRNAs was determined using receiver operating characteristic (ROC) analysis. Thirteen up-regulated and 16 down-regulated miRNAs were identified in young ACS patients...
May 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29761174/elbasvir-grazoprevir-in-asia-pacific-russian-participants-with-chronic-hepatitis-c-virus-genotype-1-4-or-6-infection
#18
Jacob George, Eduard Burnevich, I-Shyan Sheen, Jeong Heo, Nguyen Van Kinh, Tawesak Tanwandee, Pin-Nan Cheng, Do Young Kim, Won Young Tak, Svetlana Kizhlo, Konstantin Zhdanov, Vasily Isakov, Liwen Liang, Pauline Lindore, Joy Ginanni, Bach-Yen Nguyen, Janice Wahl, Eliav Barr, Michael Robertson, Paul Ingravallo, Rohit Talwani
The prevalence of hepatitis C virus (HCV) infection in Asian countries is high. This study assessed the efficacy and safety of elbasvir/grazoprevir (EBR/GZR) in participants with HCV infection from Asia-Pacific countries and Russia. In this phase 3, randomized, placebo-controlled, double-blind study, treatment-naive participants with HCV genotype (GT) 1, 4, or 6 infection were randomized to EBR 50 mg/GZR 100 mg (immediate-treatment group [ITG]) or placebo (deferred-treatment group [DTG]) once daily for 12 weeks (Protocol PN-5172-067, NCT02251990)...
May 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29760212/a-model-of-persistent-salmonella-infection-salmonella-pullorum-modulates-the-immune-response-of-the-chicken-from-a-th17-towards-a-th2-type-response
#19
Ying Tang, Neil Foster, Michael A Jones, Paul A Barrow
Salmonella enterica infection affects a wide range of animals and human and a small number of serovars cause typhoid-like infections, one characteristic of which is persistent infection in convalescents. The avian specific serovar S Pullorum produces systemic disease in young chickens which is followed by a carrier state in convalescent birds leading to infection of the ovary at sexual maturity and vertical transmission. However, the immunological basis of the persistent infection remains unclear. S. Enteritidis is taxonomically closely related but does not show this characteristic...
May 14, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29758375/alterations-in-the-microstructure-of-white-matter-in-children-and-adolescents-with-tourette-syndrome-measured-using-tract-based-spatial-statistics-and-probabilistic-tractography
#20
Hilmar P Sigurdsson, Sophia E Pépés, Georgina M Jackson, Amelia Draper, Paul S Morgan, Stephen R Jackson
Tourette syndrome (TS) is a neurodevelopmental disorder characterised by repetitive and intermittent motor and vocal tics. TS is thought to reflect fronto-striatal dysfunction and the aetiology of the disorder has been linked to widespread alterations in the functional and structural integrity of the brain. The aim of this study was to assess white matter (WM) abnormalities in a large sample of young patients with TS in comparison to a sample of matched typically developing control individuals (CS) using diffusion MRI...
April 12, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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