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Paul Young

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https://www.readbyqxmd.com/read/28645941/a-first-time-in-human-study-of-gsk2636771-a-phosphoinositide-3-kinase-beta-selective-inhibitor-in-patients-with-advanced-solid-tumors
#1
Joaquin Mateo, Gopinath Ganji, Charlotte Lemech, Howard A Burris, Sae-Won Han, Karen E Swales, Shaun Decordova, Maurice P DeYoung, Deborah A Smith, Shanker Kalyana-Sundaram, Jiuhua Wu, Monica Motwani, Rakesh Kumar, Jerry M Tolson, Sun Young Rha, Hyun Cheol Chung, Joseph Paul Eder, Sunil Sharma, Yung-Jue Bang, Jeffrey R Infante, Li Yan, Johann S de Bono, Hendrik-Tobias Arkenau
The phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT) pathway is commonly activated in several tumor types. Selective targeting of p110β could result in successful pathway inhibition while avoiding the on and off target effects of pan-PI3K inhibitors. GSK2636771 is a potent, orally bioavailable, adenosine triphosphate-competitive, selective inhibitor of PI3Kβ.<br /><br />Experimental Design: <p>We evaluated the safety, pharmacokinetics, pharmacodynamics and antitumor activity of GSK2636771 to define the recommended Phase II dose (RP2D)...
June 23, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28645420/young-woman-with-abdominal-pain-and-distention
#2
Paul S Jansson, Pietro Bortoletto, Youyou Duanmu, Joshua S Rempell
No abstract text is available yet for this article.
July 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28644350/lack-of-knowledge-and-low-readiness-for-health-care-transition-in-eosinophilic-esophagitis-and-eosinophilic-gastroenteritis
#3
Swathi Eluri, Wendy M Book, Ellyn Kodroff, Mary Jo Strobel, Jessica H Gebhart, Patricia D Jones, Paul Menard-Katcher, Maria E Ferris, Evan S Dellon
OBJECTIVES: A growing population of adolescents/young adults with eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE) will need to transition from pediatric to adult health providers. Measuring health care transition (HCT) readiness is critical, but no studies have evaluated this process in EoE/EGE. We determined the scope and predictors of HCT knowledge in patients and parents with EoE/EGE and measured HCT readiness in adolescents/young adults. METHODS: We conducted an online survey of patients 13 years or older and parents of patients with EoE/EGE who were diagnosed when 25 years or younger...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28640904/correlation-of-disease-severity-with-body-weight-and-high-fat-diet-in-the-fatzo-pco-mouse
#4
Brian A Droz, Bria L Sneed, Charles V Jackson, Karen M Zimmerman, M Dodson Michael, Paul J Emmerson, Tamer Coskun, Richard G Peterson
Obesity in many current pre-clinical animal models of obesity and diabetes is mediated by monogenic mutations; these are rarely associated with the development of human obesity. A new mouse model, the FATZO mouse, has been developed to provide polygenic obesity and a metabolic pattern of hyperglycemia and hyperinsulinemia, that support the presence of insulin resistance similar to metabolic disease in patients with insulin resistance/type 2 diabetes. The FATZO mouse resulted from a cross of C57BL/6J and AKR/J mice followed by selective inbreeding for obesity, increased insulin and hyperglycemia...
2017: PloS One
https://www.readbyqxmd.com/read/28640857/glucose-dysregulation-and-response-to-common-anti-diabetic-agents-in-the-fatzo-pco-mouse
#5
Richard G Peterson, Charles Van Jackson, Karen M Zimmerman, Jorge Alsina-Fernandez, M Dodson Michael, Paul J Emmerson, Tamer Coskun
The FATZO/Pco mouse is the result of a cross of the C57BL/6J and AKR/J strains. The crossing of these two strains and the selective inbreeding for obesity, insulin resistance and hyperglycemia has resulted in an inbred strain exhibiting obesity in the presumed presence of an intact leptin pathway. Routinely used rodent models for obesity and diabetes research have a monogenic defect in leptin signaling that initiates obesity. Given that obesity and its sequelae in humans are polygenic in nature and not associated with leptin signaling defects, the FATZO mouse may represent a more translatable rodent model for study of obesity and its associated metabolic disturbances...
2017: PloS One
https://www.readbyqxmd.com/read/28640661/attrition-from-antiretroviral-treatment-services-among-pregnant-and-non-pregnant-patients-following-adoption-of-option-b-in-haiti
#6
Jean Wysler Domercant, Nancy Puttkammer, Paul Young, Krista Yuhas, Kesner François, Reynold Grand'Pierre, David Lowrance, Michelle Adler
BACKGROUND: Access to antiretroviral therapy (ART) has expanded in Haiti because of the adoption of Option B+ and the revision of treatment guidelines. Retention in care and treatment varies greatly and few studies have examined retention rates, particularly among women enrolled in Option B+. OBJECTIVE: To assess attrition among pregnant and non-pregnant patients initiating ART following adoption of Option B+ in Haiti. METHODS: Longitudinal data of adult patients initiated on ART from October 2012 through August 2014 at 73 health facilities across Haiti were analyzed using a survival analysis framework to determine levels of attrition...
2017: Global Health Action
https://www.readbyqxmd.com/read/28639259/the-cost-effectiveness-of-three-interventions-for-providing-preventive-services-to-low-income-children
#7
Ben Johnson, Nicoleta Serban, Paul M Griffin, Scott L Tomar
OBJECTIVE: We evaluated the impact of loan repayment programmes, revising Medicaid fee-for-service rates, and changing dental hygienist supervision requirements on access to preventive dental care for children in Georgia. METHODS: We estimated cost savings from the three interventions of preventive care for young children after netting out the intervention cost. We used a regression model to evaluate the impact of changing the Medicaid reimbursement rates. The impact of supervision was evaluated by comparing general and direct supervision in school-based dental sealant programmes...
June 21, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28638330/flat-vs-expressive-storytelling-young-children-s-learning-and-retention-of-a-social-robot-s-narrative
#8
Jacqueline M Kory Westlund, Sooyeon Jeong, Hae W Park, Samuel Ronfard, Aradhana Adhikari, Paul L Harris, David DeSteno, Cynthia L Breazeal
Prior research with preschool children has established that dialogic or active book reading is an effective method for expanding young children's vocabulary. In this exploratory study, we asked whether similar benefits are observed when a robot engages in dialogic reading with preschoolers. Given the established effectiveness of active reading, we also asked whether this effectiveness was critically dependent on the expressive characteristics of the robot. For approximately half the children, the robot's active reading was expressive; the robot's voice included a wide range of intonation and emotion (Expressive)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28637842/thromboembolism-in-active-ulcerative-colitis
#9
Ian Y Goh, Stefan Saric, Paul Leschke, Mark McFarlane, Pankaj K Jha
Inflammatory bowel disease (IBD) has a range of both intestinal and extraintestinal manifestations. Thromboembolism involving the arterial and/or venous systems is rare. Early recognition and treatment of thrombosis in patients with IBD may prevent progression and minimise complications. However, clear guidelines on the duration of treatment and indications for primary prophylaxis need to be established. We report a case of a young patient with ulcerative colitis, who developed multiple site arterial and venous thrombosis, all occurring within short intervals of each other...
June 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28634153/beyond-basic-feedback-in-mobile-brief-interventions-designing-sms-message-content-for-delivery-to-young-adults-during-risky-drinking-events
#10
Cassandra J C Wright, Paul M Dietze, Megan S C Lim
BACKGROUND: Brief interventions can reduce alcohol consumption in young people through screening and delivery of personally relevant feedback. Recently, Web and mobile platforms have been harnessed to increase the reach of brief interventions. Existing literature on mobile-based alcohol brief interventions indicates mixed use of theory in developing interventions. There is no research available to guide the development of SMS text messaging (short message service, SMS) interventions delivered during risky drinking events...
June 20, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28631432/profile-effects-and-toxicity-of-novel-psychoactive-substances-a-systematic-review-of-quantitative-studies
#11
Sulaf Assi, Nargilya Gulyamova, Kinda Ibrahim, Paul Kneller, David Osselton
OBJECTIVE: To investigate the profile, effects, and toxicity of novel psychoactive substances (NPS). METHODS: A systematic literature review was conducted between May 2015 and February 2016 and included 19 databases. Search terms included "novel psychoactive substance(s)," "effect(s)," and "toxicity" and their synonyms. Studies included were those from any country, in any language, and between January 2007 and April 2015. Studies published before 2007 and those regarding the synthesis of NPS were excluded...
June 19, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28630629/the-cedar-study-a-longitudinal-study-of-the-clinical-effects-of-conventional-dmards-and-biologic-dmards-in-australian-rheumatology-practice
#12
Lynden Roberts, Kathleen Tymms, Julien de Jager, Geoffrey Littlejohn, Hedley Griffiths, Dave Nicholls, Paul Bird, Jennifer Young, Julie Hill, Jane Zochling
OBJECTIVES: To observe the choices of conventional disease modifying antirheumatic drugs (cDMARDs) and biologic DMARDs (bDMARDs) in the management of rheumatoid arthritis (RA) in Australian routine clinical practice, to assess treatment survival and determine the effect of cDMARDs/bDMARDs on disease activity. METHODS: Routinely collected, deidentified clinical data was sourced from 20 Australian rheumatology practices. RA patients aged ≥18 years, who had received cDMARDs/bDMARDs and a recorded subsequent visit, were included...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28630236/european-evidence-based-recommendations-for-diagnosis-and-treatment-of-childhood-onset-systemic-lupus-erythematosus-the-share-initiative
#13
Noortje Groot, Nienke de Graeff, Tadej Avcin, Brigitte Bader-Meunier, Paul Brogan, Pavla Dolezalova, Brian Feldman, Isabelle Kone-Paut, Pekka Lahdenne, Stephen D Marks, Liza McCann, Seza Ozen, Clarissa Pilkington, Angelo Ravelli, Annet van Royen-Kerkhof, Yosef Uziel, Bas Vastert, Nico Wulffraat, Sylvia Kamphuis, Michael W Beresford
Childhood-onset systemic lupus erythematosus (cSLE) is a rare, multisystem and potentially life-threatening autoimmune disorder with significant associated morbidity. Evidence-based guidelines are sparse and management is often based on clinical expertise. SHARE (Single Hub and Access point for paediatric Rheumatology in Europe) was launched to optimise and disseminate management regimens for children and young adults with rheumatic diseases like cSLE. Here, we provide evidence-based recommendations for diagnosis and treatment of cSLE...
June 19, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28628610/outcome-of-cardiac-surgery-in-patients-with-congenital-heart-disease-in-england-between-1997-and-2015
#14
Aleksander Kempny, Konstantinos Dimopoulos, Anselm Uebing, Gerhard-Paul Diller, Ulrich Rosendahl, George Belitsis, Michael A Gatzoulis, Stephen J Wort
BACKGROUND: The number of patients with congenital heart disease (CHD) is increasing worldwide and most of them will require cardiac surgery, once or more, during their lifetime. The total volume of cardiac surgery in CHD patients at a national level and the associated mortality and predictors of death associated with surgery are not known. We aimed to investigate the surgical volume and associated mortality in CHD patients in England. METHODS: Using a national hospital episode statistics database, we identified all CHD patients undergoing cardiac surgery in England between 1997 and 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28628369/premier-league-academy-soccer-players-experiences-of-competing-in-a-tournament-bio-banded-for-biological-maturation
#15
Sean P Cumming, Daniel J Brown, Siobhan Mitchell, James Bunce, Dan Hunt, Chris Hedges, Gregory Crane, Aleks Gross, Sam Scott, Ed Franklin, Dave Breakspear, Luke Dennison, Paul White, Andrew Cain, Joey C Eisenmann, Robert M Malina
Individual differences in the growth and maturation have been shown to impact player performance and development in youth soccer. This study investigated Premier League academy players' experiences of participating in a tournament bio-banded for biological maturation. Players (N = 66) from four professional soccer clubs aged 11 and 14 years and between 85-90% of adult stature participated in a tournament. Players competed in three 11 vs 11 games on a full size pitch with 25-min halves. Sixteen players participated in four 15-min focus groups and were asked to describe their experiences of participating in the bio-banded tournament in comparison to age group competition...
June 19, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28627000/pencil-beam-scanned-protons-for-the-treatment-of-patients-with-ewing-sarcoma
#16
Damien C Weber, Fritz R Murray, Dora Correia, Alessandra Bolsi, Martina Frei-Welte, Alessia Pica, Antony J Lomax, Ralf Schneider, Barbara Bachtiary
BACKGROUND: Few data exist regarding the clinical outcome of patients with Ewing sarcoma (EWS) treated with pencil beam scanning proton therapy (PT). We report the outcome of children, adolescents and young adults (AYA) treated with PT at the Paul Scherrer Institute. MATERIALS: Thirty-eight patients (median age, 9.9 years) received a median dose of 54.9 Gy(RBE) (where RBE is relative biologic effectiveness). Size of the tumor ranged from 1.7 to 24 cm. Most common primary site was axial/pelvic (n = 27; 71%)...
June 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28626969/different-patterns-of-expression-of-cell-cycle-control-and-local-invasion-related-proteins-in-oral-squamous-cell-carcinoma-affecting-young-patients
#17
Marisol Miranda Galvis, Alan Roger Santos-Silva, Juscelino Freitas Jardim, Felipe Paiva Fonseca, Marcio A Lopes, Oslei P Almeida, Clóvis A Lópes Pinto, Estela Kaminagakura, Iris Sawazaki-Calone, Paul M Speight, Luiz Paulo Kowalski
Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide and the clinical and behavioral characteristics of tumors in this group are controversial and the literature shows divergent results PURPOSE: To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤ 40 years old) METHODS: A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs...
June 19, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28625807/evidence-for-altered-levels-of-immunoglobulin-d-in-the-nasal-airway-mucosa-of-patients-with-chronic-rhinosinusitis
#18
Jin-Young Min, Jayakar V Nayak, Kathryn E Hulse, Whitney W Stevens, Paul A Raju, Julia H Huang, Lydia A Suh, Griet A Van Roey, James E Norton, Roderick G Carter, Caroline P E Price, Ava R Weibman, Ali R Rashan, Eliver E Ghosn, Zara M Patel, Tetsuya Homma, David B Conley, Kevin C Welch, Stephanie Shintani-Smith, Anju T Peters, Leslie C Grammer, Kathleen E Harris, Atsushi Kato, Peter H Hwang, Robert C Kern, Leonore A Herzenberg, Robert P Schleimer, Bruce K Tan
BACKGROUND: Immunoglobulin D (IgD) is an enigmatic antibody isotype best known when co-expressed with IgM on naïve B cells. However, elevated soluble IgD (sIgD) and increased IgD(+)IgM(-) B cell populations have been described in the human upper respiratory mucosa. OBJECTIVE: We assessed whether levels of sIgD and IgD(+) B cells are altered in nasal tissue from patients with chronic rhinosinusitis (CRS). We further characterized IgD(+) B cell populations and explored clinical and local inflammatory factors associated with tissue sIgD levels...
June 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28625713/individual-and-area-level-ses-in-diabetes-risk-prediction-the-multi-ethnic-study-of-atherosclerosis
#19
Paul J Christine, Rebekah Young, Sara D Adar, Alain G Bertoni, Michele Heisler, Mercedes R Carnethon, Rodney A Hayward, Ana V Diez Roux
INTRODUCTION: The purpose of this study was to evaluate if adding SES to risk prediction models based upon traditional risk factors improves the prediction of diabetes. METHODS: Risk prediction models without and with individual- and area-level SES predictors were compared using the prospective Multi-Ethnic Study of Atherosclerosis. Cox proportional hazards models were utilized to estimate hazard ratios for SES predictors and to generate 10-year predicted risks for 5,021 individuals without diabetes at baseline followed from 2000 to 2012...
June 15, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28624722/age-related-differences-in-the-response-of-the-l5-s1-intervertebral-disc-to-spinal-traction
#20
Ulrike H Mitchell, Paul F Beattie, Jennifer Bowden, Robert Larson, Haonan Wang
BACKGROUND: Lumbar traction is a common treatment for low back pain; however its mechanisms of action are poorly understood. It has been hypothesized that a key effect of lumbar traction is its capacity to influence fluid movement within the intervertebral disc (IVD). OBJECTIVES: To determine differences in the apparent diffusion coefficient (ADC) obtained with lumbar diffusion-weighted imaging (DWI) of the L5-S1 IVD before, and during, the application of lumbar traction...
June 9, 2017: Musculoskeletal Science & Practice
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