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Paul Young

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https://www.readbyqxmd.com/read/28818230/symptomatic-compression-of-right-iliac-vein-after-right-iliac-artery-stent-placement
#1
Lindsay Young, Jeontaik Kwon, Mariano Arosemena, Dawn Salvatore, Paul DiMuzio, Babak Abai
Right lower extremity edema can be a presenting symptom of iliocaval compression syndrome, even in the absence of deep vein thrombosis. It has been reported in idiopathic and rarely, iatrogenic, cases secondary to variant anatomy, arterial stents, and bony hardware. Classically seen in the more confined left common iliac vein as May-Thurner syndrome, it is rare on the right side. We report an unusual case of acute right common iliac vein compression after right iliac stent placement leading to symptomatic right leg edema...
September 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28814674/rilonacept-maintains-long-term-inflammatory-remission-in-patients-with-deficiency-of-the-il-1-receptor-antagonist
#2
Megha Garg, Adriana A de Jesus, Dawn Chapelle, Paul Dancey, Ronit Herzog, Rafael Rivas-Chacon, Theresa L Wampler Muskardin, Ann Reed, James C Reynolds, Raphaela Goldbach-Mansky, Gina A Montealegre Sanchez
BACKGROUND: Deficiency of IL-1 receptor antagonist (DIRA) is a rare autoinflammatory disease that presents with life-threatening systemic inflammation, aseptic multifocal osteomyelitis, and pustulosis responsive to IL-1-blocking treatment. This study was performed (a) to investigate rilonacept, a long-acting IL-1 inhibitor, in maintaining anakinra-induced inflammatory remission in DIRA patients, (b) to determine doses needed to maintain remission, and (c) to evaluate the safety and pharmacokinetics of rilonacept in young children (<12 years)...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28813597/synthesis-of-4-azido-n-acetylhexosamine-uridine-diphosphate-donors-clickable-glycosaminoglycans
#3
Xing Zhang, Dixy E Green, Victor L Schultz, Lei Lin, Xiaorui Han, Ruitong Wang, Alexander Yaksic, So Young Kim, Paul L DeAngelis, Robert J Linhardt
Unnatural chemically modified, nucleotide sugars, UDP-4-N3-GlcNAc and UDP-4-N3-GalNAc were synthesized for the first time. These unnatural UDP-sugar products were then tested for incorporation into hyaluronan, heparosan or chondroitin using polysaccharide synthases. The UDP-4-N3-GlcNAc served as a chain termination substrate for hyaluronan or heparosan synthases; a single analog was added to the non-reducing end of the sugar chain and no subsequent elongation was detected. Compared to chemical method to introduce azido groups into polysaccharides, this enzymatic technique provided a "green" approach to access regioselectively azide-functionalized GAGs, which would bring better control of the final structure and composition of these macromolecules...
August 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28813437/a-systematic-review-of-the-relationship-between-internet-use-self-harm-and-suicidal-behaviour-in-young-people-the-good-the-bad-and-the-unknown
#4
Amanda Marchant, Keith Hawton, Ann Stewart, Paul Montgomery, Vinod Singaravelu, Keith Lloyd, Nicola Purdy, Kate Daine, Ann John
BACKGROUND: Research exploring internet use and self-harm is rapidly expanding amidst concerns regarding influences of on-line activities on self-harm and suicide, especially in young people. We aimed to systematically review evidence regarding the potential influence of the internet on self-harm/suicidal behaviour in young people. METHODS: We conducted a systematic review based on an electronic search for articles published between 01/01/2011 and 26/01/2015 across databases including Medline, Cochrane and PsychInfo...
2017: PloS One
https://www.readbyqxmd.com/read/28812974/the-psychological-effects-of-unemployment-and-unsatisfactory-employment-on-young-adults-findings-from-a-10-year-longitudinal-study
#5
Anthony H Winefield, Paul H Delfabbro, Helen R Winefield, David Duong, Catia Malvaso
The purpose of the present study was to extend the external validity of an earlier longitudinal study of school leavers by including participants from a representative sample of secondary schools. Questionnaires were administered annually to a sample of South Australian school leavers over a 10-year period. At Time 1 participants were in the last compulsory year of high school aged around 15 years and at Time 10 they were aged around 25 years. Results confirmed those from an earlier longitudinal study showing that the transition from school to satisfactory employment was associated with significant improvements in psychological well-being, whereas transition from school to unemployment or unsatisfactory employment showed no change in psychological well-being...
July 2017: Journal of Genetic Psychology
https://www.readbyqxmd.com/read/28808429/fast-reliable-3d-amide-proton-transfer-imaging-of-brain-tumors-at-3t-with-variably-accelerated-sensitivity-encoding-vsense
#6
Yi Zhang, Hye-Young Heo, Shanshan Jiang, Paul A Bottomley, Jinyuan Zhou
The clinical use of amide proton transfer (APT) imaging is hindered by long scan times. Accuracy generally limits the use of conventional sensitivity encoding (SENSE) methods in APT, to an acceleration factor of 2. A novel variably-accelerated sensitivity encoding (vSENSE) method can provide more accurate results and therefore substantially higher overall acceleration factors than conventional SENSE. Here, vSENSE is further developed to eliminate the requirement that one fully-sampled APT frame be acquired, and extended to three dimensions (3D)...
April 2017: Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition
https://www.readbyqxmd.com/read/28806761/transcriptome-analysis-of-pdgfr%C3%AE-cells-identifies-t-type-ca2-channel-cacna1g-as-a-new-pathological-marker-for-pdgfr%C3%AE-cell-hyperplasia
#7
Se Eun Ha, Moon Young Lee, Masaaki Kurahashi, Lai Wei, Brian G Jorgensen, Chanjae Park, Paul J Park, Doug Redelman, Kent C Sasse, Laren S Becker, Kenton M Sanders, Seungil Ro
Platelet-derived growth factor receptor alpha (PDGFRα)+ cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal layers as well as the myenteric and deep muscular plexi. PDGFRα+ cells directly interact with interstitial cells of Cajal (ICC) and smooth muscle cells (SMC) in gastrointestinal smooth muscle tissue. These three cell types, SMC, ICC, and PDGFRα+ cells (SIP cells), form an electrical syncytium, which dynamically regulates gastrointestinal motility. We have previously reported the transcriptomes of SMC and ICC...
2017: PloS One
https://www.readbyqxmd.com/read/28806050/linking-high-throughput-screens-to-identify-moas-and-novel-inhibitors-of-mycobacterium-tuberculosis-dihydrofolate-reductase
#8
John P Santa Maria, Yumi Park, Lihu Yang, Nicholas Murgolo, Michael D Altman, Paul Zuck, Greg Adam, Chad Chamberlin, Peter Saradjian, Peter Dandliker, Helena I M Boshoff, Clifton E Barry, Charles Garlisi, David B Olsen, Katherine Young, Meir Glick, Elliott Nickbarg, Peter S Kutchukian
Though phenotypic and target-based high-throughput screening approaches have been employed to discover new antibiotics, the identification of promising therapeutic candidates remains challenging. Each approach provides different information, and understanding their results can provide hypotheses for mechanism of action (MoA) and reveal actionable chemical matter. Here we describe a framework for identifying efficacy targets of bioactive compounds. High throughput biophysical profiling against a broad range of targets coupled with machine learning is employed to identify chemical features with predicted efficacy targets for a given phenotypic screen...
August 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28806029/atrial-fibrillation-induced-by-carbon-monoxide-poisoning-and-successful-treatment-with-hyperbaric-oxygen
#9
Maheedhar Gedela, Nathan Y Weltman, Naga Sushma Chavvakula, Paul L Carpenter, Tamera Sturm
Carbon monoxide (CO) intoxication is one of the major public health hazards which may go unnoticed as this is a colorless, odorless and tasteless gas. The manifestations of the CO poisoning are far-reaching. Although CO affects almost every organ in the body, cerebral and myocardial involvement are predominant due to the hypoxia-induced cellular damage. The mainstay treatment is providing high-flow oxygen and in some instances hyperbaric oxygen therapy. In the literature, there have been few cases of CO poisoning-induced atrial fibrillation (AF) reported...
July 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28805932/muscle-thickness-correlates-to-muscle-cross-sectional-area-in-the-assessment-of-strength-training-induced-hypertrophy
#10
Martino V Franchi, Stefano Longo, Joanne Mallinson, Jonathan I Quinlan, Tariq Taylor, Paul L Greenhaff, Marco V Narici
AIM: Muscle thickness (MT) measured by ultrasound has been used to estimate cross-sectional area (measured by CT and MRI) at a single time-point. We tested whether MT could be used as a valid marker of MRI determined muscle anatomical cross-sectional area (ACSA) and volume changes following resistance training (RT). METHODS: Nine healthy, young, male volunteers (24±2 y.o., BMI 24.1±2.8 kg/m(2) ) had vastus lateralis (VL) muscle volume (VOL) and ACSA mid (at 50% of femur length, FL) assessed by MRI, and VL MT measured by ultrasound at 50% FL...
August 14, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28805579/nonmotor-manifestations-of-wilson-s-disease
#11
Samar Biswas, Neelanjana Paul, Shyamal K Das
Wilson disease (WD) is an autosomal genetic disorder characterized by excessive copper deposition initially in liver (hepatic variant) followed by brain (neuropsychiatric variant) and other organs such as cornea and kidney due to defect in biliary copper excretion. Predominant presentations of neuropsychiatric variant are extrapyramidal motor dysfunctions such as dystonias, Parkinsonism, choreoathetosis, tremor, and ataxias. Nonmotor symptoms (NMS) can appear before clinical disease expression and during ongoing disease process...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28802314/aoac-smpr-%C3%A2-2017-012
#12
Anton Bzhelyansky, Gisele Atkinson, LaVerne Brown, Paul Burns, Nour Eddine Es-Safi, Christine Farthing, Adam Horkey, Holly Johnson, Adam Kuszak, Andy Lippert, Elizabeth Mudge, Tom Phillips, Klaus Reif, Catherine Rimmer, Aniko Solyom, John Szpylka, John Travis, Jinchuan Yang, Hong You, Kurt Young, Scott Coates
No abstract text is available yet for this article.
July 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28801755/a-cross-national-comparison-of-violence-among-young-men-in-china-and-the-uk-psychiatric-and-cultural-explanations
#13
Jeremy Coid, Junmei Hu, Constantinos Kallis, Yuan Ping, Juying Zhang, Yueying Hu, Laura Bui, Simone Ullrich, Paul Bebbington
PURPOSE: Public health psychiatry has a key role in violence prevention. Cross-national comparisons of violence and associated psychiatric morbidity can indicate targets for preventive interventions. METHOD: Data on young adult men in households, 18-34 years, were drawn from the Second Men's Modern Lifestyles survey in Great Britain (n = 2046) and from a corresponding survey in Chengdu, China (n = 4132), using a translated questionnaire. Binary logistic regression models were carried out to estimate the cross-national differences for different types of violence and to identify explanatory variables...
August 11, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28800305/influence-of-chronic-neck-pain-on-cervical-joint-position-error-jpe-comparison-between-young-and-elderly-subjects
#14
Khalid A Alahmari, Ravi Shankar Reddy, Paul Silvia, Irshad Ahmad, Venkat Nagaraj, Mohammad Mahtab
BACKGROUND: Evaluation of cervical joint position sense in subjects with chronic neck pain has gained importance in recent times. Different authors have established increased joint position error (JPE) in subjects with acute neck pain. However, there is a paucity of studies to establish the influence of chronic neck pain on cervical JPE. OBJECTIVE: The objective of the study was to understand the influence of chronic neck pain on cervical JPE, and to examine the differences in cervical JPE between young and elderly subjects with chronic neck pain...
August 3, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28799886/longitudinal-effects-of-personality-on-physical-activity-among-college-students-examining-executive-function-as-a-potential-moderator
#15
Chelsea Joyner, Paul D Loprinzi
Objective The purpose of this study was to examine the relationship between personality and physical activity, with a specific focus on whether executive function moderates this relationship. Methods One hundred twenty-six young adults provided complete data at baseline and the five-month follow-up assessment. Executive function was assessed via the parametric Go/No-Go computer task; outcome measures of parametric Go/No-Go were mean reaction time and percent of correct target detection across executive function tasks (simple rule and repeating rule)...
January 1, 2017: Psychological Reports
https://www.readbyqxmd.com/read/28797086/epigenetic-differences-between-monozygotic-twins-discordant-for-amyotrophic-lateral-sclerosis-als-provide-clues-to-disease-pathogenesis
#16
Paul E Young, Stephen Kum Jew, Michael E Buckland, Roger Pamphlett, Catherine M Suter
Amyotrophic lateral sclerosis (ALS) is a devastating late-onset neurodegenerative disorder in which only a small proportion of patients carry an identifiable causative genetic lesion. Despite high heritability estimates, a genetic etiology for most sporadic ALS remains elusive. Here we report the epigenetic profiling of five monozygotic twin pairs discordant for ALS, four with classic ALS and one with the progressive muscular atrophy ALS variant, in whom previous whole genome sequencing failed to uncover a genetic basis for their disease discordance...
2017: PloS One
https://www.readbyqxmd.com/read/28795728/the-air-we-breathe-past-present-and-future-general-discussion
#17
Scott Archer-Nicholls, Alexander Archibald, Stephen Arnold, Thorsten Bartels-Rausch, Steven Brown, Lucy J Carpenter, William Collins, Luke Conibear, Ruth Doherty, Rachel Dunmore, Jacinta Edebeli, Morgan Edwards, Mathew Evans, Barbara Finlayson-Pitts, Jacqueline Hamilton, Meredith Hastings, Colette Heald, Dwayne Heard, Markus Kalberer, Christopher Kampf, Astrid Kiendler-Scharr, Daniel Knopf, Jesse Kroll, Forrest Lacey, Jos Lelieveld, Eloise Marais, Jennifer Murphy, Olajide Olawoyin, A Ravishankara, Jonathan Reid, Yinon Rudich, Drew Shindell, Nadine Unger, Andreas Wahner, Timothy J Wallington, Jonathan Williams, Paul Young, Alla Zelenyuk
No abstract text is available yet for this article.
August 10, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28795727/atmospheric-chemistry-and-the-biosphere-general-discussion
#18
Alexander Archibald, Stephen Arnold, Lustinian Bejan, Steven Brown, Martin Brüggemann, Lucy J Carpenter, William Collins, Mathew Evans, Barbara Finlayson-Pitts, Christian George, Meredith Hastings, Dwayne Heard, C N Hewitt, Gabriel Isaacman-VanWertz, Markus Kalberer, Frank Keutsch, Astrid Kiendler-Scharr, Daniel Knopf, Jos Lelieveld, Eloise Marais, Andreas Petzold, A Ravishankara, Jonathan Reid, Grazia Rovelli, Catherine Scott, Tomás Sherwen, Drew Shindell, Liselotte Tinel, Nadine Unger, Andreas Wahner, Timothy J Wallington, Jonathan Williams, Paul Young, Alla Zelenyuk
No abstract text is available yet for this article.
August 10, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28794957/prevalence-of-metabolic-syndrome-and-metabolic-syndrome-components-in-young-adults-a-pooled-analysis
#19
Paul B Nolan, Graeme Carrick-Ranson, James W Stinear, Stacey A Reading, Lance C Dalleck
Metabolic syndrome (MetSyn) represents a clustering of different metabolic abnormalities. MetSyn prevalence is present in approximately 25% of all adults with increased prevalence in advanced ages. The presence of one component of MetSyn increases the risk of developing MetSyn later in life and likely represents a high lifetime burden of cardiovascular disease risk. Therefore we pooled data from multiple studies to establish the prevalence of MetSyn and MetSyn component prevalence across a broad range of ethnicities...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28794060/assessment-of-health-related-quality-of-life-and-psychological-well-being-of-children-and-adolescents-with-obesity-enrolled-in-a-new-zealand-community-based-intervention-programme-an-observational-study
#20
Yvonne C Anderson, Lisa E Wynter, Katharine F Treves, Cameron C Grant, Joanna M Stewart, Tami L Cave, Trecia A Wouldes, José G B Derraik, Wayne S Cutfield, Paul L Hofman
OBJECTIVE: To describe health-related quality of life (HRQOL) and psychological well-being of children and adolescents at enrolment in a multidisciplinary community-based obesity programme and to determine association with ethnicity. This programme targeted indigenous people and those from most deprived households. Further, this cohort was compared with other populations/normative data. METHODS: This study examines baseline demographic data of an unblinded randomised controlled clinical trial...
August 9, 2017: BMJ Open
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