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https://www.readbyqxmd.com/read/29037012/medical-treatment-of-intracranial-atherosclerosis-an-update
#1
REVIEW
Jong S Kim, Oh Young Bang
For patients with symptomatic intracranial atherosclerosis (ICAS), antithrombotic agents are the mainstay of therapy. Anticoagulation (warfarin) is not widely used since it is not more effective than aspirin and carries a high risk of bleeding. New oral anticoagulants are showing promise, but their use has not been investigated in appropriate clinical trials. Since the recurrent stroke risk is high with aspirin monotherapy, dual antiplatelets are considered in the early stage of symptomatic ICAS. Based on the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) and Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) results, aspirin plus clopidogrel has been recommended...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29037010/effects-of-triflusal-and-clopidogrel-on-the-secondary-prevention-of-stroke-based-on-cytochrome-p450-2c19-genotyping
#2
Sang Won Han, Yong-Jae Kim, Seong Hwan Ahn, Woo-Keun Seo, Sungwook Yu, Seung-Hun Oh, Hyo Suk Nam, Hye-Yeon Choi, Sung Sang Yoon, Seo Hyun Kim, Jong Yun Lee, Jun Hong Lee, Yang-Ha Hwang, Kee Ook Lee, Yo Han Jung, Jun Lee, Sung-Il Sohn, Youn Nam Kim, Kyung-A Lee, Cheryl D Bushnell, Kyung-Yul Lee
BACKGROUND AND PURPOSE: To compare the efficacy and safety of antiplatelet agents for the secondary prevention of ischemic stroke based on cytochrome P450 2C19 (CYP2C19) polymorphisms. METHODS: This study was a prospective, multicenter, randomized, parallel-group, open-label, blind genotype trial. First time non-cardiogenic ischemic stroke patients were enrolled and screened within 30 days. Participants were randomized to receive either triflusal or clopidogrel for secondary stroke prevention...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29036933/school-leadership-and-cyberbullying-a-multilevel-analysis
#3
Sara B Låftman, Viveca Östberg, Bitte Modin
Cyberbullying is a relatively new form of bullying, with both similarities and differences to traditional bullying. While earlier research has examined associations between school-contextual characteristics and traditional bullying, fewer studies have focused on the links to students' involvement in cyberbullying behavior. The aim of the present study is to assess whether school-contextual conditions in terms of teachers' ratings of the school leadership are associated with the occurrence of cyberbullying victimization and perpetration among students...
October 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29035965/effectiveness-of-bedrails-in-preventing-falls-among-hospitalized-older-adults-a-systematic-review
#4
Paulo Marques, Carmen Queirós, João Apóstolo, Daniela Cardoso
BACKGROUND: Falls are a major problem today affecting adults of any age, but the elderly are a population that is more susceptible to falls. Falls are the leading cause of injury or death among older adults. Hospitalized older people are particularly vulnerable to falls. Falls cause direct injuries (minor injuries, severe wounds of the soft tissues and bone fractures) to patients and increased length of stay. The prevention of falls is commonly considered an indicator of the quality of care...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035924/rotational-therapy-in-thoracic-injuries-what-is-the-evidence
#5
Philipp Störmann, Ingo Marzi, Sebastian Wutzler
PURPOSE OF REVIEW: To review the current use of continuous lateral rotational therapy (CLRT) in patients with thoracic injuries and its impact on clinical course, complications and outcome. RECENT FINDINGS: Patient positioning is a key factor in the treatment of severe thoracic injuries and CLRT, and intermittent supine and prone position are basic options. There is a lack of randomized controlled studies for trauma patients with chest injury undergoing kinetic therapy as standard of care...
October 14, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29035427/differences-in-the-korea-acute-myocardial-infarction-registry-compared-with-western-registries
#6
REVIEW
Doo Sun Sim, Myung Ho Jeong
The Korea Acute Myocardial Infarction Registry (KAMIR) is the first nationwide registry that reflects current therapeutic approaches and acute myocardial infarction (AMI) management in Korea. The results of the KAMIR demonstrated different risk factors and responses to medical and interventional treatments. The results indicated that the incidence of ST-elevation myocardial infarction (STEMI) was relatively high, and that the prevalence of dyslipidemia was relatively low with higher triglyceride and lower high-density lipoprotein cholesterol levels...
September 18, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29035425/inhaled-versus-systemic-corticosteroids-for-the-treatment-of-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-infants
#7
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: This is an update of a review published in 2012. A related review "Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates" has been updated as well. Bronchopulmonary dysplasia (BPD) is a serious and common problem among very low birth weight infants, despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome. Due to their anti-inflammatory properties, corticosteroids have been widely used to treat or prevent BPD...
October 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29035064/two-subtypes-of-psychopathic-criminals-differ-in-negative-affect-and-history-of-childhood-abuse
#8
Monika Dargis, Michael Koenigs
OBJECTIVE: Specification of the etiological mechanisms underlying psychopathy is a key step in developing more effective methods for preventing and remediating the callous and impulsive behavior that characterizes the disorder. Theoretical conceptualizations of psychopathic subtypes propose that a primary variant largely stems from impoverished affect, whereas a secondary variant is hypothesized to develop subsequent to adverse environmental experiences (e.g., childhood maltreatment)...
October 16, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29034706/chronic-lymphocytic-leukaemia-and-secondary-skin-malignancies
#9
Geraldine Kyle
Chronic lymphocytic leukaemia (CLL) is a non-Hodgkin lymphoma commonly occurring in older adults. Many people with CLL can go for years without requiring treatment. However, they have an increased risk of secondary cancers, specifically melanoma and non-melanoma skin cancers. Furthermore, these secondary cancers are frequently more aggressive in this cohort of patients. Health professionals working in haematology, dermatology and general practice have an opportunity to educate patients about risk factors and measures to aid prevention...
October 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29034117/correlates-of-cervical-cancer-screening-among-adult-latino-women-a-5-year-follow-up
#10
Patria Rojas, Tan Li, Gira J Ravelo, Christyl Dawson, Mariana Sanchez, Alicia Sneij, Weize Wang, Mariano Kanamori, Elena Cyrus, Mario R De La Rosa
BACKGROUND: Latinas have the highest incidence rates of cervical cancer in the United States, and Latinas in the United States are less likely to utilize cervical cancer screening. METHOD: We used secondary data analysis of a non-clinical convenience sample (n=316 women at baseline; n=285 at five-year follow-up) to examine correlates of cervical cancer screening among adult Latina women. Univariate and multiple logistic regression models using Generalized Estimated Equations (GEE) algorithm were utilized to assess the influence of the independent variables...
June 2017: World Medical & Health Policy
https://www.readbyqxmd.com/read/29033616/nationwide-trends-of-clinical-characteristics-and-economic-burden-of-emergency-department-visits-due-to-acute-ischemic-stroke
#11
Mark Stuntz, Katsiaryna Busko, Shumaila Irshad, Taylor Paige, Veranika Razhkova, Tim Coan
We aimed to provide estimates of the volume and associated charges of acute ischemic stroke (AIS) visits in the US, as well as to assess predictors of patient disposition following an emergency department (ED) visit for AIS. Our study was conducted using the 2010-2013 data from the Nationwide Emergency Department Sample. We identified adult visits with AIS as the primary diagnosis. A generalized linear model was used to calculate mean charges per visit after adjusting for covariates. Multinomial logistic regression was used to assess predictors of patient disposition following an ED visit for AIS...
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/29033503/the-management-and-prognostic-factors-of-acute-coronary-syndrome-evidence-from-the-taiwan-acute-coronary-syndrome-full-spectrum-registry
#12
REVIEW
Chun-Yuan Chu, Tsung-Hsien Lin, Wen-Ter Lai
Cardiovascular disease (CVD) accounts for approximately one-third of all global deaths, and acute coronary syndrome (ACS) is the most severe form of CVD. It is of notable importance to develop ACS strategies for reducing major adverse cardiac events (MACE) and preventing complications. In the Taiwan ACS Full Spectrum Registry, 1-year mortality among patients with ST-segment elevation myocardial infarction, non ST-segment elevation myocardial infarction and unstable angina was 6.1%, 10.1%, and 6.2%, respectively...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29033355/evaluation-of-the-effect-of-serratus-anterior-plane-block-for-pain-treatment-after-video-assisted-thoracoscopic-surgery
#13
Korgun Okmen, Burcu Metin Okmen
BACKGROUND: Analgesia following video-assisted thoracoscopic surgery (VATS) is important for the prevention of postoperative pulmonary complications. Various regional methods of anaesthesia are currently being used to achieve this goal. In our study, we aim to assess the effectiveness of SAPB on postoperative VATS analgesia in our study. METHODS: A total of 40 patients aged between 18 and 70 years, those who were in the Society of Anaesthesiologists (ASA) I-III class and underwent VATS were included in the study...
October 12, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29033336/open-abdomen-therapy-with-vacuum-and-mesh-mediated-fascial-traction-after-aortic-repair-an-international-multicentre-study
#14
Stefan Acosta, Arne Seternes, Maarit Venermo, Leena Vikatmaa, Karl Sörelius, Anders Wanhainen, Mats Svensson, Khatereh Djavani, Martin Björck
OBJECTIVES: Open abdomen therapy may be necessary to prevent or treat abdominal compartment syndrome (ACS). The aim of the study was to analyse the primary delayed fascial closure (PDFC) rate and complications after open abdomen therapy with vacuum and mesh mediated fascial traction (VACM) after aortic repair and to compare outcomes between those treated with open abdomen after primary versus secondary operation. METHODS: This was a retrospective cohort, multicentre study in Sweden, Finland, and Norway, including consecutive patients treated with open abdomen and VACM after aortic repair at six vascular centres in 2006-2015...
October 12, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29033229/analysis-of-recurrent-stroke-volume-and-prognosis-between-warfarin-and-four-non-vitamin-k-antagonist-oral-anticoagulants-administration-for-secondary-prevention-of-stroke
#15
Yukie Kanai, Hiroaki Oguro, Nao Tahara, Hanako Matsuda, Hiroyuki Takayoshi, Shingo Mitaki, Keiichi Onoda, Shuhei Yamaguchi
OBJECTIVE: We investigated recurrent stroke volume with nonvalvular atrial fibrillation (NVAF) patients treated with non-vitamin K antagonist oral anticoagulants (NOACs) about clinical backgrounds and number of recurrent stroke. METHODS: We administered 4 NOACs, dabigatran, rivaroxaban, apixaban, and edoxaban in 101 postcardioembolic strokes with NVAF. In a retrospective study, we measured recurrent stroke volume with magnetic resonance imaging volumetric software and compared them between 10 vitamin K anticoagulant (VKA: warfarin) cases and 13 NOAC cases under anticoagulant therapy...
October 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29032937/challenges-and-opportunities-to-scale-up-cardiovascular-disease-secondary-prevention-in-latin-america-and-the-caribbean
#16
Álvaro Avezum, Pablo Perel, Gustavo B F Oliveira, Patricio Lopez-Jaramillo, Gustavo Restrepo, Fleetwood Loustalot, Andrea Srur, Reinaldo de La Noval, Kenneth I Connell, Salvador Cruz-Flores, Lenildo de Moura, Gabriela Castellac, Antonio C Mattos, Pedro Ordunez
No abstract text is available yet for this article.
October 9, 2017: Global Heart
https://www.readbyqxmd.com/read/29032772/influenza-vaccination-status-and-outcomes-among-influenza-associated-hospitalizations-in-columbus-ohio-2012-2015
#17
P N Zivich, L Tatham, K Lung, J Tien, C E Bollinger, J K Bower
Prior studies suggest that the influenza vaccine is protective against some outcomes in hospitalized patients infected with influenza despite vaccination. We utilized surveillance data from Columbus, Ohio to investigate this association over multiple influenza seasons and age groups. Data on laboratory-confirmed influenza-associated hospitalizations were collected as a part of the Influenza Hospitalization Surveillance Project for the 2012-2013, 2013-2014, and 2014-2015 influenza seasons. The association between influenza vaccination status was examined in relation to the outcomes of severe influenza and diagnosis of pneumonia among patients receiving antiviral treatment...
October 16, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29032062/virus-specific-t-cells-broadening-applicability
#18
REVIEW
A John Barrett, Susan Prockop, Catherine M Bollard
Virus infection still remains an appreciable cause of morbidity and mortality after Hematopoietic stem cell transplant (HSCT). While pharmacotherapy and/or antibody therapy may help to prevent or treat viral disease, these drugs are expensive, toxic and often ineffective due to primary or secondary resistance. Further, effective treatments are limited for many infections (e.g. Ad and BKV), which are increasingly detected after alternative donor transplants. These deficiencies in conventional therapeutics have increased interest in an immunotherapeutic approach to viral disorders, leading to adoptive transfer of virus-specific cytotoxic T lymphocytes (VSTs), which can rapidly reconstitute antiviral immunity post-transplant without causing GvHD...
October 11, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29032023/social-determinants-of-drug-related-mortality-in-a-general-population
#19
Sanna Rönkä, Karoliina Karjalainen, Pekka Martikainen, Pia Mäkelä
BACKGROUND: We investigated the association between social determinants and a broad selection of drug-related deaths in a general population. METHODS: We conducted a follow-up of an 11% random sample of working-age Finnish residents for 1996-2007 linked with an oversampling of deaths and population registration data on social characteristics. We defined total drug-related deaths as those from psychoactive substance use disorders and drug-induced poisonings (drug-induced deaths) as well as drug-related accidents, homicides, illnesses, and suicides...
October 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29031976/understanding-protein-interface-interactions-of-a-fusion-protein-at-silicone-oil-water-interface-probed-by-sum-frequency-generation-vibrational-spectroscopy
#20
Yaoxin Li, Duohai Pan, Vishal Nashine, Smeet Deshmukh, Balvinder Vig, Zhan Chen
Protein adsorbed at the silicone oil-water interface can undergo a conformational change that has the potential to induce protein aggregation upon storage. Characterization of the protein structures at interface is therefore critical for understanding the protein-interface interactions. In this paper, we have applied sum frequency generation (SFG) spectroscopy for studying the secondary structures of a fusion protein at interface and the surfactant effect on protein adsorption to silicone oil-water interface...
October 11, 2017: Journal of Pharmaceutical Sciences
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