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https://www.readbyqxmd.com/read/29930873/intracranial-complications-of-acute-bacterial-endocarditis
#1
Burke A Cunha, Ismail Jimada, Karishma Chawla
Background: Infectious endocarditis (IE) clinically manifests as either subacute bacterial endocarditis (SBE) or acute bacterial endocarditis (ABE). Neurologic manifestations are markedly different for these two entities. ABE is caused by invasive, highly virulent pathogens (e.g., Staphylococcus aureus ), whereas SBE is attributed to relatively avirulent, non-invasive organisms (e.g., viridans streptococci ). Methods: Here, we reviewed the clinical and radiographic presentations of a patient with cranial complications attributed to ABE...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29890540/rehabilitation-after-clipping-of-cerebral-aneurysms-without-acute-subarachnoid-hemorrhage-outcome-analysis-of-100-consecutive-cases
#2
Andreas Jödicke, Karsten Bauer, Andrea Hajdukova
BACKGROUND:  Discharge to rehabilitation is reported in large studies as one important outcome parameter based on hospital codes. Because neurologic outcome scores (e.g., the modified Rankin Scale [mRS]) are missing in International Classification of Diseases (ICD) databases, rehabilitation indirectly serves as a kind of surrogate parameter for overall outcome. Reported fractions of patients with rehabilitation, however, largely differ between studies and seem high for patients with aneurysm clipping...
June 11, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29858886/transesophageal-ultrasonography-during-orthotopic-liver-transplantation-show-me-more
#3
REVIEW
Luigi Vetrugno, Federico Barnariol, Elena Bignami, Grazia D Centonze, Adelisa De Flaviis, Federico Piccioni, Elisabetta Auci, Tiziana Bove
The first perioperative transesophageal echocardiography (TEE) guidelines published 21 years ago were mainly addressed to cardiac anesthesiologists. TEE has since expanded its role outside this setting and currently represents an invaluable tool to assess chamber sizes, ventricular hypertrophy, and systolic, diastolic, and valvular function in patients undergoing orthotopic liver transplantation (OLT). Right-sided microemboli, right ventricular dysfunction, and patent foramen ovale (PFO) are the most common intra-operative findings described during OLT...
June 2, 2018: Echocardiography
https://www.readbyqxmd.com/read/29850543/rs4612666-polymorphism-of-the-nlrp3-gene-is-associated-with-the-occurrence-of-large-artery-atherosclerotic-ischemic-strokes-and-microembolic-signals
#4
Lufeng Cheng, Ruihua Yin, Shaonan Yang, Xudong Pan, Aijun Ma
Purpose: Large artery atherosclerosis (LAA) ischemic stroke (IS) is the most common IS subtype, and microemboli are clinically important for indicating an increased risk of IS. Nucleotide-binding domain-like receptor protein 3 (NLRP3) plays a crucial role in the pathogenesis of atherosclerosis. The aim of this study is to investigate the relationship between NLRP3 gene polymorphisms and susceptibility for LAA IS and microembolic signals (MES) in the Chinese Han population. Methods: We studied 293 patients diagnosed with LAA IS and 265 controls...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29753882/circulating-tumor-microemboli-progress-in-molecular-understanding-and-enrichment-technologies
#5
REVIEW
Muhammad Umer, Ramanathan Vaidyanathan, Nam-Trung Nguyen, Muhammad J A Shiddiky
Circulating tumor cells (CTCs) and their clusters, also known as circulating tumor microemboli (CTM), have emerged as valuable tool that can provide mechanistic insights into the tumor heterogeneity, clonal evolution, and stochastic events within the metastatic cascade. However, recent investigations have hinted that CTM may not be mere aggregates of tumor cells but cells comprising CTM exhibit distinct phenotypic and molecular characteristics in comparison to single CTCs. Moreover, in many cases CTM demonstrated higher metastatic potential and resistance to apoptosis as compared to their single cell counterparts...
May 10, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29734574/sensorineural-hearing-loss-after-spine-surgery-treated-with-hyperbaric-oxygen-therapy-two-case-reports
#6
Eric Goodrich, Richard P Goodrich, Charles A Reese
Acute idiopathic sudden sensorineural hearing loss (ISSNHL) following lumbar spinal surgery is an exceedingly rare phenomenon. This paper presents a case of ISSNHL presenting acutely after lumbar spine decompression and fusion treated with transtympanic steroids and hyperbaric oxygen (HBO₂) therapy. It also presents the ironic case of SSNHL secondary to presumed viral pathology sustained by the patient's operative surgeon who was treated with transtympanic steroids and HBO₂ as well. Proposed etiologies of the patient's ISSNHL include: hypotension, prone operative position, malfitted/malpositioned headrest, microemboli from a cell-saver, and nitrous oxide anesthesia...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29725451/prognostic-significance-of-circulating-tumor-microemboli-in-patients-with-pancreatic-ductal-adenocarcinoma
#7
Guangdong Wu, Rongrong Zhu, Yatong Li, Yupei Zhao, Menghua Dai
The significance of circulating tumor microemboli (CTMs) in patients with pancreatic ductal adenocarcinoma (PDAC) is still unknown. Thus, the present study used a epithelial cellular adhesion molecule independent subtraction and immunostaining-fluorescence in situ hybridization (SET-iFISH) platform to enumerate circulating tumor cells (CTCs) and CTMs in a total of 86 peripheral blood samples from 19 patients with PDAC. The associations between CTCs and CTMs with clinicopathologic factors and prognoses were analyzed...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29621827/validation-of-the-automated-electronic-microemboli-detection-system
#8
Ruud Keunen
No abstract text is available yet for this article.
April 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29620085/cerebral-microemboli-detection-for-monitoring-structural-cardiac-disease
#9
Mohammad Shafie, Shlee Song, Mani Nezhad, John Lamberti, Mark Cocalis, Michael Cavallaro, Brenda Rinsky, Patrick Lyden
No abstract text is available yet for this article.
October 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29562937/cerebral-microembolism-in-the-critically-ill-with-acute-kidney-injury-comet-aki-trial-study-protocol-for-a-randomized-controlled-clinical-trial
#10
Gabor Erdoes, Dominik E Uehlinger, Beatrice Kobel, Monika P Stucki, Roland Wiest, Frank Stueber, Niklaus Fankhauser, Stephan M Jakob, Joerg C Schefold
BACKGROUND: Microembolism is a frequent pathological event during extracorporeal renal replacement therapy (RRT). Some previous data indicate that microemboli are generated in patients who are undergoing RRT and that these may contribute to increased cerebrovascular and neurocognitive morbidity in patients with end-stage renal disease. The current trial aims to quantify the microembolic load and respective qualitative composition that effectively reaches the intracerebral circulation in critically ill patients treated with different RRT modalities for acute kidney injury (AKI)...
March 21, 2018: Trials
https://www.readbyqxmd.com/read/29510275/headache-outcomes-after-coil-embolization-in-patients-with-unruptured-intracranial-aneurysms-do-they-get-better-or-worse-a-prospective-analysis
#11
Jung Hyun Park, Hoon Kim, Seong Rim Kim, Ik Seong Park, Min Seok Byeon, Young Woo Kim
BACKGROUND: To investigate the association between headache outcomes and coil embolization and to identify potential factors associated with different headache outcomes in patients with unruptured intracranial aneurysms (UIAs) after treatment with coil embolization. METHODS: A prospective study of patients with planned coil embolization for UIAs was conducted. The changes in headache patterns, headache-related disability, and depression were assessed before coil embolization and at 3 days and 2 and 6 weeks after coil embolization...
March 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29507780/association-of-homocysteine-and-smoking-with-cerebral-microemboli-in-patients-with-mechanical-heart-valves-a-transcranial-doppler-study
#12
Alicia Mattia, M Reza Azarpazhooh, Claudio Munoz, Chrysi Bogiatzi, Mackenzie A Quantz, J David Spence
Objectives: Microembolic signals (MES) on transcranial Doppler (TCD) predict stroke and cognitive decline. Plasma levels of total homocysteine (tHcy), a prothrombotic factor, are higher in patients with microemboli in carotid stenosis and in patients with paradoxical embolism. In this study we assessed the association between the level of tHcy and the number of MES in patients with mechanical heart valves (MHVs). Methods: TCD monitoring was performed to detect MES before and after breathing 100% oxygen and repeated every 2-4 weeks up to six times...
December 2017: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/29430677/cutaneous-refractile-foreign-body-microemboli-with-intravascular-injection-of-oral-medication
#13
Nicholas Bercovici, Kristen Russomanno, Frank Santoro, Christopher Scola, Michael Murphy, Zendee Elaba
Injection drug abuse (IDA) is known to cause a spectrum of systemic and cutaneous complications. Despite the increasing incidence of IDA around the world, there is a paucity of literature discussing cutaneous complications from a dermatopathologic perspective. We present a case of a 35-year-old male with a complex medical history of Von Willebrand disease, Beçhet disease and diverticular disease. Following a sigmoidectomy/colostomy for diverticular perforation, he presented with fever and an indurated right arm displaying livedoid purpura...
May 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29422972/detection-of-circulating-tumor-cells-in-pulmonary-venous-blood-for-resectable-non-small-cell-lung-cancer
#14
Chao Lv, Bingtian Zhao, Limin Wang, Panpan Zhang, Yuanyuan Ma, Yuzhao Wang, Nan Wu, Ying Wu, Yue Yang
Intraoperative manipulation causes circulating tumor cell (CTC) shedding into the blood and accelerates metastasis in non-small cell lung cancer (NSCLC). The present study was conducted to assess the degree of dissemination resulting from surgery and to explore the biological features of CTCs. In patients with NSCLC who underwent complete resection, the pulmonary vein (PV) was isolated and stapled following thoracotomy. The number of CTCs retained per 7.5 ml PV blood (CTC-PV) and peripheral blood were detected...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29394136/egfr-expression-in-circulating-tumor-cells-from-high-grade-metastatic-soft-tissue-sarcomas
#15
Alexcia Camila Braun, Celso Abdon Lopes de Mello, Marcelo Corassa, Emne Ali Abdallah, Ana Cláudia Urvanegia, Vanessa Silva Alves, Bianca C T C P Flores, Mônica Díaz, Ulisses Ribaldo Nicolau, Virgilio Souza E Silva, Vinicius Calsavara, Patrizia Paterlini-Brechót, Ludmilla Thomé Domingos Chinen
INTRODUCTION: Soft tissue Sarcomas (STS) are rare malignances, with high mortality rates. Half of patients develop metastasis. The presence of isolated Circulating Tumor Cells (CTCs) and Circulating Tumor Microemboli (CTM) in the blood may be early markers of tumor invasion. Epidermal Growth Factor (EGF) family receptors can also influence this process. OBJECTIVES: to quantify CTCs and identify CTM as well as the EGF Receptor (EGFR) protein expression in these cells and correlate with clinical outcome in metastatic STS...
June 3, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29377185/in-vitro-comparison-of-pediatric-oxygenators-with-and-without-integrated-arterial-filters-in-maintaining-optimal-hemodynamic-stability-and-managing-gaseous-microemboli
#16
Morgan Moroi, Madison Force, Shigang Wang, Allen R Kunselman, Akif Ündar
The purpose of this study was to compare the Capiox FX15 oxygenator with integrated arterial filter to the Capiox RX15 oxygenator with separate Capiox AF125 arterial filter in terms of hemodynamic properties and gaseous microemboli (GME) capturing. Trials were conducted at varying flow rates (2.0 L/min, 3.0 L/min, 4.0 L/min), temperatures (30°C, 35°C), and flow modalities (pulsatile, nonpulsatile). Pressure and flow waveforms were recorded using a custom-made data acquisition system. GME data were recorded using an Emboli Detection and Classification Quantifier after injecting a 5 mL air bolus into the venous line...
April 2018: Artificial Organs
https://www.readbyqxmd.com/read/29355381/detection-of-microembolic-signals-in-the-common-carotid-artery-using-doppler-sonography-in-the-porcine-model-of-acute-heart-failure-treated-by-veno-arterial-extracorporeal-membrane-oxygenation
#17
D Janák, P Hála, M Mlček, M Popková, S Lacko, J Kudlička, O Kittnar
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a method used for the treatment most severe cases of decompensated heart failure. The purpose of this study was to evaluate the risk of the formation of microembolisms during VA-ECMO-based therapy. Heart failure was induced with simultaneous detection of microembolisms and the measurement of blood flow rate in the common carotid artery (CCA) without VA-ECMO (0 l/min) and at the VA-ECMO blood flow rate of 1, 2, 3 and 4 l/min. If embolisms for VA-ECMO 0 l/min and the individual regimes for VA-ECMO 1, 2, 3, 4 l/min are compared, a higher VA-ECMO flow rate is accompanied by a higher number of microembolisms...
December 30, 2017: Physiological Research
https://www.readbyqxmd.com/read/29316662/recurrent-hemorrhagic-conversion-of-ischemic-stroke-in-a-patient-with-mechanical-heart-valve-a-case-report-and-literature-review
#18
Micheal Jace Tarver, Tyler Schmidt, Michael T Koltz
The authors present a unique case of recurrent stroke, discovered to be secondary to hemorrhagic conversion of microemboli from a mechanical aortic valve despite anticoagulation with Coumadin. The complexity of this case was magnified by the patient's young age, a mechanical heart valve (MHV), and a need for anticoagulation to maintain MHV patency in a setting of potentially life-threatening intracranial hemorrhage. Anticoagulant and antiplatelet therapy are risk factors for hemorrhagic conversion post-cerebral ischemia; however, the pathophysiology underlying endothelial cell dysfunction causing red blood cell extravasation is an active area of basic and clinical research...
January 7, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29302117/an-in-vitro-study-comparing-the-gme-handling-of-two-contemporary-oxygenators
#19
COMPARATIVE STUDY
Carl J Gisnarian, Angela Hedman, Kenneth G Shann
Gaseous microemboli (GME) are a potential complication of cardiopulmonary bypass (CPB). Though it is difficult to prove that GME is the only major cause of neurological deficits, it may increase the chance of post-operative cognitive dysfunction if not removed. The objectives of this research were to compare LivaNova-Sorin Inspire (Inspire) oxygenator with a Medtronic arterial filter to the Medtronic Fusion (Fusion) oxygenator with and without a Medtronic arterial filter based on each system's ability to handle GME...
December 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29281787/promoting-multivalent-antibody-antigen-interactions-by-tethering-antibody-molecules-on-a-pegylated-dendrimer-supported-lipid-bilayer
#20
Po-Ying Yeh, Yih-Ruey Chen, Chien-Fang Wang, Ying-Chih Chang
To efficiently isolate maximal quantity of circulating tumor cells (CTCs) and circulating tumor cell microembolis (CTMs) from patient blood by antibody coated microfluidics, a multifunctional, pegylated polyamidoamine-dendrimers conjugated supported lipid bilayer surface construct was proposed to enhance accessibility of antibody molecules to the antigen molecules on target CTCs. The combination of a hydrated, stretchable dendrimer and a laterally mobile supported lipid bilayer (SLB) provide attached antibody molecules with 2...
February 12, 2018: Biomacromolecules
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