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https://www.readbyqxmd.com/read/29143228/effect-of-exosome-biomarkers-for-diagnosis-and-prognosis-of-breast-cancer-patients
#1
REVIEW
M Wang, S Ji, G Shao, J Zhang, K Zhao, Z Wang, A Wu
PURPOSE: Exosomes are gradually detected as an indicator for diagnosis and prognosis of breast cancer in clinic and a systematic review was conducted. METHODS: A search for clinical studies published before July 1, 2017 was performed. Methods of exosome purification and identification from all studies were extracted. For diagnosis evaluation, the comparison of exosome biomarkers expression between breast cancer patients and healthy women was obtained; for prognosis prediction, the correlation between exosome biomarkers expression and chemotherapy resistance, overall survival (OS), disease-free survival (DFS), recurrence and metastasis of breast cancer was also extracted...
November 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29042871/application-of-array-comparative-genomic-hybridization-in-korean-children-under-6-years-old-with-global-developmental-delay
#2
Kyung Yeon Lee, Eunsim Shin
PURPOSE: Recent advancements in molecular techniques have greatly contributed to the discovery of genetic causes of unexplained developmental delay. Here, we describe the results of array comparative genomic hybridization (CGH) and the clinical features of 27 patients with global developmental delay. METHODS: We included 27 children who fulfilled the following criteria: Korean children under 6 years with global developmental delay; children who had at least one or more physical or neurological problem other than global developmental delay; and patients in whom both array CGH and G-banded karyotyping tests were performed...
September 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28846069/secreted-protein-del-1-regulates-myelopoiesis-in-the-hematopoietic-stem-cell-niche
#3
Ioannis Mitroulis, Lan-Sun Chen, Rashim Pal Singh, Ioannis Kourtzelis, Matina Economopoulou, Tetsuhiro Kajikawa, Maria Troullinaki, Athanasios Ziogas, Klara Ruppova, Kavita Hosur, Tomoki Maekawa, Baomei Wang, Pallavi Subramanian, Torsten Tonn, Panayotis Verginis, Malte von Bonin, Manja Wobus, Martin Bornhäuser, Tatyana Grinenko, Marianna Di Scala, Andres Hidalgo, Ben Wielockx, George Hajishengallis, Triantafyllos Chavakis
Hematopoietic stem cells (HSCs) remain mostly quiescent under steady-state conditions but switch to a proliferative state following hematopoietic stress, e.g., bone marrow (BM) injury, transplantation, or systemic infection and inflammation. The homeostatic balance between quiescence, self-renewal, and differentiation of HSCs is strongly dependent on their interactions with cells that constitute a specialized microanatomical environment in the BM known as the HSC niche. Here, we identified the secreted extracellular matrix protein Del-1 as a component and regulator of the HSC niche...
October 2, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28693030/prevalencia-de-alteraciones-en-la-interfase-vitreoretiniana-detectadas-mediante-tomograf%C3%A3-a-de-coherencia-%C3%A3-ptica-de-dominio-espectral
#4
Julie Jacob, Peter Stalmans
Objetivo: El objetivo principal del presente estudio consistió en determinar la prevalencia de los cambios en la interfase vitreomacular (IVM) mediante tomografía de coherencia óptica (OCT) en la población general. En segundo lugar, se describieron otros cambios de la OCT. Métodos: Las anomalías en la IVM se diagnosticaron mediante OCT y se distribuyeron de acuerdo con la clasificación del grupo International Vitreomacular Traction Study (estudio internacional de tracción vitreomacular, IVTS, por sus siglas en inglés) y se dividieron en 3 grados según John et al...
July 11, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28643381/clinical-association-between-chronic-periodontitis-and-the-leukocyte-extravasation-inhibitors-developmental-endothelial-locus-1-and-pentraxin-3
#5
Matthias Folwaczny, Evangelia Karnesi, Tamara Berger, Ekaterini Paschos
This clinical study aimed to determine whether periodontal disease is associated with expression of developmental endothelial locus-1 (Del-1) and pentraxin-3 (PTX-3), endogenous inhibitors of leukocyte extravasation in humans. Expression of DEL1, PTX3, interleukin-17A (IL17A), and lymphocyte function-associated antigen-1 (LFA1) was determined, using RT-PCR and melting curve analysis, in biopsies of gingival tissues from 95 patients: 42 with moderate periodontitis; 40 with severe periodontitis; and 13 healthy controls...
June 23, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28627201/degree-of-malnutrition-and-its-relationship-with-major-structural-and-eating-factors-in-honduran-preschool-population-prevalence-of-breastfeeding
#6
Lorena Fernández Palacios, Elsa Barrientos Augustinus, Carolina Raudales Urquía, Carmen Frontela Saseta, Gaspar Ros Berruezo
Introduction: Child malnutrition remains a serious public health problem in Honduras, with a national prevalence according to the World Health Organization (WHO) reference values of 29% in children under fi ve. In addition, the average chronic malnutrition in the region amounts to 80% in poor and indigenous communities, making Honduras the second country in Central America with the highest incidence of chronic malnutrition. Another problem of the region is the early cessation of exclusive breastfeeding: only 29...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28447099/endogenous-developmental-endothelial-locus-1-limits-ischaemia-related-angiogenesis-by-blocking-inflammation
#7
Anne Klotzsche-von Ameln, Sebastian Cremer, Jedrzej Hoffmann, Peggy Schuster, Sherif Khedr, Irina Korovina, Maria Troullinaki, Ales Neuwirth, David Sprott, Antonios Chatzigeorgiou, Matina Economopoulou, Alessia Orlandi, Andreas Hain, Andreas M Zeiher, Andreas Deussen, George Hajishengallis, Stefanie Dimmeler, Triantafyllos Chavakis, Emmanouil Chavakis
We have recently identified endothelial cell-secreted developmental endothelial locus-1 (Del-1) as an endogenous inhibitor of β2-integrin-dependent leukocyte infiltration. Del-1 was previously also implicated in angiogenesis. Here, we addressed the role of endogenously produced Del-1 in ischaemia-related angiogenesis. Intriguingly, Del-1-deficient mice displayed increased neovascularisation in two independent ischaemic models (retinopathy of prematurity and hind-limb ischaemia), as compared to Del-1-proficient mice...
June 2, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28363656/structural-variations-of-lignin-macromolecule-from-different-growth-years-of-triploid-of-populus-tomentosa-carr
#8
Tian-Ying Chen, Bing Wang, Yu-Ying Wu, Jia-Long Wen, Chuan-Fu Liu, Tong-Qi Yuan, Run-Cang Sun
To better understand the variations of structural characteristics of lignin macromolecules during different growth years of Triploid of Populus tomentosa Carr, a novel lignin isolation procedure based on double ball-milling and enzymatic hydrolysis (DEL) was proposed in this study. The morphological distributions of lignin in the plant cell wall of these poplar wood samples were monitored by Confocal Raman Microscopy (CRM). The ultrahigh yields (105.1%-111.2%) of DELs were significantly higher than those (24...
August 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27784857/developmental-endothelial-locus-1-del-1-inhibits-oxidized-low-density-lipoprotein-activity-by-direct-binding-and-its-overexpression-attenuates-atherogenesis-in-mice
#9
Akemi Kakino, Yoshiko Fujita, Atsushi Nakano, Sayaka Horiuchi, Tatsuya Sawamura
BACKGROUND: Modified low-density lipoprotein (LDL) binding to scavenger receptors has been implicated in atherosclerosis. It is hypothesized that a third molecule may affect modified LDL binding, therefore, this study focuses on the soluble endogenous protein, developmental endothelial locus-1 (Del-1), as an inhibitor of oxidized LDL (oxLDL) interactions.Methods and Results:Del-1 preferentially bound oxLDL over native LDL in a cell-free binding assay. Del-1 also inhibited DiI-labeled oxLDL uptake by scavenger receptors irrespective of the receptor type (LOX-1, SR-AI, CD36, or SR-BI) expressed in COS-7 cells, and independent of cell type (human coronary artery endothelial cells (HCAECs) or THP-1-derived macrophages)...
November 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27759985/adecuaci%C3%A3-n-de-las-peticiones-de-los-niveles-de-vitamina-d-al-laboratorio
#10
Francisco Javier Valero Chávez, Luis Miguel Luengo Pérez, Javier Cubero Juánez
Introducción: ante las nuevas implicaciones atribuidas a la vitamina D y la asociación con enfermedades tales como el cáncer, diabetes, enfermedades cardiovasculares, autoinmunes y mortalidad, no es de extrañar que se haya defendido la medición de los niveles de vitamina D en la población general. Sin embargo, no existen datos experimentales que demuestren la viabilidad y rentabilidad de la estrategia de cribado en la población y tampoco se ha comprobado la existencia de beneficios para la salud, por lo que en la actualidad solo es aconsejable la medida de 25 (OH) vitamina D en los grupos de personas de alto riesgo como indican las guías clínicas internacionales...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27664585/characterization-of-a-novel-acquired-der-1-del-1-p13p31-t-1-15-q42-q15-in-a-high-risk-t-12-21-positive-acute-lymphoblastic-leukemia
#11
Eigil Kjeldsen
The t(12;21)(p13;q22) with ETV6-RUNX1 fusion occurs in 25% of cases of B-cell precursor acute lymphoblastic leukemia (BCP-ALL); and is generally associated with favorable prognosis. However, 15-20% of the t(12;21)-positive cases are associated with high-risk disease due to for example slow early responses to therapy. It is well-known that development of overt leukemia in t(12;21)-positive ALL requires secondary chromosomal aberrations although the full spectrum of these cytogenetic alterations is yet unsettled, and also, how they may be associated with disease outcome...
December 20, 2016: Gene
https://www.readbyqxmd.com/read/27635612/-mutation-del-1-02kb-in-the-cln3-gene-and-extrapyramidal-syndrome
#12
E P Nuzhnyi, A F Yakimovskii, A A Timofeeva, T S Usenko, M A Nikolaev, A K Emelyanov, V I Amosov, E V Bubnova, A M Boukina, E Yu Zakharova, S N Pchelina
Mutations in the GBA and SMPD1 genes, which lead to the development of lysosomal storage diseases, are high risk factors for Parkinson's disease and dementia with Lewy bodies. We screened the mutations in the GALC and CLN3 genes in patients with Parkinson's disease and control subjects. A heterozygous CLN3 mutation (del 1.02 kb) carrier with clinical features of the unusual extrapyramidal syndrome was identified. A role of CLN3 mutations in the development of neurodegenerative disorders is discussed.
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27459347/transferring-desirable-genes-from-agropyron-cristatum-7p-chromosome-into-common-wheat
#13
Mingjie Lu, Yuqing Lu, Huanhuan Li, Cuili Pan, Yong Guo, Jinpeng Zhang, Xinming Yang, Xiuquan Li, Weihua Liu, Lihui Li
Wheat-Agropyron cristatum 7P disomic addition line Ⅱ-5-1, derived from the distant hybridization between A. cristatum (2n = 4x = 28, PPPP) and the common wheat cv. Fukuhokomugi (Fukuho), displays numerous desirable agronomic traits, including enhanced thousand-grain weight, smaller flag leaf, and enhanced tolerance to drought. In order to transfer these traits into common wheat, Ⅱ-5-1 was induced by 60Co-γ ray, leading to the creation of 18 translocation lines and three deletion lines. Genomic in situ hybridization (GISH) and fluorescence in situ hybridization (FISH) indicated that multiple wheat chromosomes were involved in the translocation events, including chromosome 2A, 3A, 5A, 7A, 3B, 5B, 7B, 3D and 7D...
2016: PloS One
https://www.readbyqxmd.com/read/27436264/copy-number-variations-in-375-patients-with-oesophageal-atresia-and-or-tracheoesophageal-fistula
#14
Erwin Brosens, Florian Marsch, Elisabeth M de Jong, Hitisha P Zaveri, Alina C Hilger, Vera Gisela Choinitzki, Alice Hölscher, Per Hoffmann, Stefan Herms, Thomas M Boemers, Benno M Ure, Martin Lacher, Michael Ludwig, Bert H Eussen, Robert M van der Helm, Hannie Douben, Diane Van Opstal, Rene M H Wijnen, H Berna Beverloo, Yolande van Bever, Alice S Brooks, Hanneke IJsselstijn, Daryl A Scott, Johannes Schumacher, Dick Tibboel, Heiko Reutter, Annelies de Klein
Oesophageal atresia (OA) with or without tracheoesophageal fistula (TOF) are rare anatomical congenital malformations whose cause is unknown in over 90% of patients. A genetic background is suggested, and among the reported genetic defects are copy number variations (CNVs). We hypothesized that CNVs contribute to OA/TOF development. Quantifying their prevalence could aid in genetic diagnosis and clinical care strategies. Therefore, we profiled 375 patients in a combined Dutch, American and German cohort via genomic microarray and compared the CNV profiles with their unaffected parents and published control cohorts...
December 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27238810/eficacia-del-entrenamiento-diario-de-una-repetici%C3%A3-n-de-m%C3%A3-ximo-peso-en-levantadores-de-pesas-bien-entrenados-una-serie-de-casos
#15
Michael C Zourdos, Chad Dolan, Justin M Quiles, Alex Klemp, Edward Jo, Jeremy P Loenneke, Rocky Blanco, Michael Whitehurst
No abstract text is available yet for this article.
March 25, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27125607/-percutaneous-coronary-intervention-in-navarre-outcomes-of-a-low-volume-centre
#16
M Artaiz, N Salterain, A Fernández Montero, A Hernández-Hernández, J P Canepa Leite, J Calabuig Nogués
BACKGROUND: Percutaneous coronary intervention (PCI)is currently a basic therapeutic option in patients with coronary artery disease. To carry this out specialists must be trained and accredited. It is known that the number of procedures performed each year influences results. We suggest that some low volume centres may also get good results. METHODS: Prospective analysis of clinical features and immediate results obtained in our centre following PCI performed between 2006 and 2012 and retrospective analysis of overall survival, outcome-free survival and restenosis in patients treated between 2006 and 2009...
April 29, 2016: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/26676803/developmental-endothelial-locus-1-modulates-platelet-monocyte-interactions-and-instant-blood-mediated-inflammatory-reaction-in-islet-transplantation
#17
Ioannis Kourtzelis, Klara Kotlabova, Jong-Hyung Lim, Ioannis Mitroulis, Anaisa Ferreira, Lan-Sun Chen, Bettina Gercken, Anja Steffen, Elisabeth Kemter, Anne Klotzsche-von Ameln, Claudia Waskow, Kavita Hosur, Antonios Chatzigeorgiou, Barbara Ludwig, Eckhard Wolf, George Hajishengallis, Triantafyllos Chavakis
Platelet-monocyte interactions are strongly implicated in thrombo-inflammatory injury by actively contributing to intravascular inflammation, leukocyte recruitment to inflamed sites, and the amplification of the procoagulant response. Instant blood-mediated inflammatory reaction (IBMIR) represents thrombo-inflammatory injury elicited upon pancreatic islet transplantation (islet-Tx), thereby dramatically affecting transplant survival and function. Developmental endothelial locus-1 (Del-1) is a functionally versatile endothelial cell-derived homeostatic factor with anti-inflammatory properties, but its potential role in IBMIR has not been previously addressed...
April 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/26603257/identification-of-developmental-endothelial-locus-1-on-circulating-extracellular-vesicles-as-a-novel-biomarker-for-early-breast-cancer-detection
#18
Pyong-Gon Moon, Jeong-Eun Lee, Young-Eun Cho, Soo Jung Lee, Jin Hyang Jung, Yee Soo Chae, Han-Ik Bae, Young-Bum Kim, In-San Kim, Ho Yong Park, Moon-Chang Baek
PURPOSE: Currently, there are no molecular biomarkers for the early detection of breast cancer. This study focused on identifying surface proteins found on circulating extracellular vesicles (EVs) for detecting early-stage breast cancer. EXPERIMENTAL DESIGN: Circulating EVs, isolated from the plasma of 10 patients with breast cancer (stages I and II) and 5 healthy controls, were analyzed using LC-MS/MS. Developmental endothelial locus-1 protein (Del-1) was selected as a candidate biomarker...
April 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26554893/regulation-of-tissue-infiltration-by-neutrophils-role-of-integrin-%C3%AE-3%C3%AE-1-and-other-factors
#19
REVIEW
Pallavi Subramanian, Ioannis Mitroulis, George Hajishengallis, Triantafyllos Chavakis
PURPOSE OF REVIEW: Neutrophils have traditionally been viewed in the context of acute infection and inflammation forming the first line of defense against invading pathogens. Neutrophil trafficking to the site of inflammation requires adhesion and transmigration through blood vessels, which is orchestrated by adhesion molecules, such as β2 and β1-integrins, chemokines, and cytokines. The review focuses on recent advances in understanding the regulators of neutrophil recruitment during inflammation in both acute and chronic settings...
January 2016: Current Opinion in Hematology
https://www.readbyqxmd.com/read/26545781/del-1-overexpression-potentiates-lung-cancer-cell-proliferation-and-invasion
#20
Seung-Hwan Lee, Dong-Young Kim, Feifeng Jing, Hyesoon Kim, Chae-Ok Yun, Deok-Jong Han, Eun Young Choi
Developmental endothelial locus-1 (Del-1) is an endogenous anti-inflammatory molecule that is highly expressed in the lung and the brain and limits leukocyte migration to these tissues. We previously reported that the expression of Del-1 is positively regulated by p53 in lung endothelial cells. Although several reports have implicated the altered expression of Del-1 gene in cancer patients, little is known about its role in tumor cells. We here investigated the effect of Del-1 on the features of human lung carcinoma cells...
December 4, 2015: Biochemical and Biophysical Research Communications
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