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https://www.readbyqxmd.com/read/28693030/prevalencia-de-alteraciones-en-la-interfase-vitreoretiniana-detectadas-mediante-tomograf%C3%A3-a-de-coherencia-%C3%A3-ptica-de-dominio-espectral
#1
Julie Jacob, Peter Stalmans
Objetivo: El objetivo principal del presente estudio consistió en determinar la prevalencia de los cambios en la interfase vitreomacular (IVM) mediante tomografía de coherencia óptica (OCT) en la población general. En segundo lugar, se describieron otros cambios de la OCT. Métodos: Las anomalías en la IVM se diagnosticaron mediante OCT y se distribuyeron de acuerdo con la clasificación del grupo International Vitreomacular Traction Study (estudio internacional de tracción vitreomacular, IVTS, por sus siglas en inglés) y se dividieron en 3 grados según John et al...
July 11, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28643381/clinical-association-between-chronic-periodontitis-and-the-leukocyte-extravasation-inhibitors-developmental-endothelial-locus-1-and-pentraxin-3
#2
Matthias Folwaczny, Evangelia Karnesi, Tamara Berger, Ekaterini Paschos
This clinical study aimed to determine whether periodontal disease is associated with expression of developmental endothelial locus-1 (Del-1) and pentraxin-3 (PTX-3), endogenous inhibitors of leukocyte extravasation in humans. Expression of DEL1, PTX3, interleukin-17A (IL17A), and lymphocyte function-associated antigen-1 (LFA1) was determined, using RT-PCR and melting curve analysis, in biopsies of gingival tissues from 95 patients: 42 with moderate periodontitis; 40 with severe periodontitis; and 13 healthy controls...
June 23, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28627201/grado-de-malnutrici%C3%A3-n-y-su-relaci%C3%A3-n-con-los-principales-factores-estructurales-y-alimentarios-de-la-poblaci%C3%A3-n-preescolar-hondure%C3%A3-a-prevalencia-de-la-lactancia-materna-en-los-mismos
#3
Lorena Fernández Palacios, Elsa Barrientos Augustinus, Carolina Raudales Urquía, Carmen Frontela Saseta, Gaspar Ros Berruezo
Introducción: la desnutrición infantil sigue siendo un grave problema de salud pública en Honduras, con una prevalencia nacional según valores de referencia de la Organización Mundial de la Salud (OMS) del 29% en niños menores de cinco años. Además, el promedio de desnutrición crónica en la región asciende hasta el 80% en comunidades pobres e indígenas, convirtiendo a Honduras en el segundo país en la región centroamericana con mayor incidencia de desnutrición crónica. Otro de los problemas que presenta la región resulta del abandono precoz de la lactancia materna exclusiva: solo el 29,7% de los menores fue alimentado exclusivamente con leche materna hasta los seis meses...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28447099/endogenous-developmental-endothelial-locus-1-limits-ischaemia-related-angiogenesis-by-blocking-inflammation
#4
Anne Klotzsche-von Ameln, Sebastian Cremer, Jedrzej Hoffmann, Peggy Schuster, Sherif Khedr, Irina Korovina, Maria Troullinaki, Ales Neuwirth, David Sprott, Antonios Chatzigeorgiou, Matina Economopoulou, Alessia Orlandi, Andreas Hain, Andreas M Zeiher, Andreas Deussen, George Hajishengallis, Stefanie Dimmeler, Triantafyllos Chavakis, Emmanouil Chavakis
We have recently identified endothelial cell-secreted developmental endothelial locus-1 (Del-1) as an endogenous inhibitor of β2-integrin-dependent leukocyte infiltration. Del-1 was previously also implicated in angiogenesis. Here, we addressed the role of endogenously produced Del-1 in ischaemia-related angiogenesis. Intriguingly, Del-1-deficient mice displayed increased neovascularisation in two independent ischaemic models (retinopathy of prematurity and hind-limb ischaemia), as compared to Del-1-proficient mice...
June 2, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28363656/structural-variations-of-lignin-macromolecule-from-different-growth-years-of-triploid-of-populus-tomentosa-carr
#5
Tian-Ying Chen, Bing Wang, Yu-Ying Wu, Jia-Long Wen, Chuan-Fu Liu, Tong-Qi Yuan, Run-Cang Sun
To better understand the variations of structural characteristics of lignin macromolecules during different growth years of Triploid of Populus tomentosa Carr, a novel lignin isolation procedure based on double ball-milling and enzymatic hydrolysis (DEL) was proposed in this study. The morphological distributions of lignin in the plant cell wall of these poplar wood samples were monitored by Confocal Raman Microscopy (CRM). The ultrahigh yields (105.1%-111.2%) of DELs were significantly higher than those (24...
August 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27784857/developmental-endothelial-locus-1-del-1-inhibits-oxidized-low-density-lipoprotein-activity-by-direct-binding-and-its-overexpression-attenuates-atherogenesis-in-mice
#6
Akemi Kakino, Yoshiko Fujita, Atsushi Nakano, Sayaka Horiuchi, Tatsuya Sawamura
BACKGROUND: Modified low-density lipoprotein (LDL) binding to scavenger receptors has been implicated in atherosclerosis. It is hypothesized that a third molecule may affect modified LDL binding, therefore, this study focuses on the soluble endogenous protein, developmental endothelial locus-1 (Del-1), as an inhibitor of oxidized LDL (oxLDL) interactions.Methods and Results:Del-1 preferentially bound oxLDL over native LDL in a cell-free binding assay. Del-1 also inhibited DiI-labeled oxLDL uptake by scavenger receptors irrespective of the receptor type (LOX-1, SR-AI, CD36, or SR-BI) expressed in COS-7 cells, and independent of cell type (human coronary artery endothelial cells (HCAECs) or THP-1-derived macrophages)...
November 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27759985/adecuaci%C3%A3-n-de-las-peticiones-de-los-niveles-de-vitamina-d-al-laboratorio
#7
Francisco Javier Valero Chávez, Luis Miguel Luengo Pérez, Javier Cubero Juánez
Introducción: ante las nuevas implicaciones atribuidas a la vitamina D y la asociación con enfermedades tales como el cáncer, diabetes, enfermedades cardiovasculares, autoinmunes y mortalidad, no es de extrañar que se haya defendido la medición de los niveles de vitamina D en la población general. Sin embargo, no existen datos experimentales que demuestren la viabilidad y rentabilidad de la estrategia de cribado en la población y tampoco se ha comprobado la existencia de beneficios para la salud, por lo que en la actualidad solo es aconsejable la medida de 25 (OH) vitamina D en los grupos de personas de alto riesgo como indican las guías clínicas internacionales...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27664585/characterization-of-a-novel-acquired-der-1-del-1-p13p31-t-1-15-q42-q15-in-a-high-risk-t-12-21-positive-acute-lymphoblastic-leukemia
#8
Eigil Kjeldsen
The t(12;21)(p13;q22) with ETV6-RUNX1 fusion occurs in 25% of cases of B-cell precursor acute lymphoblastic leukemia (BCP-ALL); and is generally associated with favorable prognosis. However, 15-20% of the t(12;21)-positive cases are associated with high-risk disease due to for example slow early responses to therapy. It is well-known that development of overt leukemia in t(12;21)-positive ALL requires secondary chromosomal aberrations although the full spectrum of these cytogenetic alterations is yet unsettled, and also, how they may be associated with disease outcome...
December 20, 2016: Gene
https://www.readbyqxmd.com/read/27635612/-mutation-del-1-02kb-in-the-cln3-gene-and-extrapyramidal-syndrome
#9
E P Nuzhnyi, A F Yakimovskii, A A Timofeeva, T S Usenko, M A Nikolaev, A K Emelyanov, V I Amosov, E V Bubnova, A M Boukina, E Yu Zakharova, S N Pchelina
Mutations in the GBA and SMPD1 genes, which lead to the development of lysosomal storage diseases, are high risk factors for Parkinson's disease and dementia with Lewy bodies. We screened the mutations in the GALC and CLN3 genes in patients with Parkinson's disease and control subjects. A heterozygous CLN3 mutation (del 1.02 kb) carrier with clinical features of the unusual extrapyramidal syndrome was identified. A role of CLN3 mutations in the development of neurodegenerative disorders is discussed.
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27459347/transferring-desirable-genes-from-agropyron-cristatum-7p-chromosome-into-common-wheat
#10
Mingjie Lu, Yuqing Lu, Huanhuan Li, Cuili Pan, Yong Guo, Jinpeng Zhang, Xinming Yang, Xiuquan Li, Weihua Liu, Lihui Li
Wheat-Agropyron cristatum 7P disomic addition line Ⅱ-5-1, derived from the distant hybridization between A. cristatum (2n = 4x = 28, PPPP) and the common wheat cv. Fukuhokomugi (Fukuho), displays numerous desirable agronomic traits, including enhanced thousand-grain weight, smaller flag leaf, and enhanced tolerance to drought. In order to transfer these traits into common wheat, Ⅱ-5-1 was induced by 60Co-γ ray, leading to the creation of 18 translocation lines and three deletion lines. Genomic in situ hybridization (GISH) and fluorescence in situ hybridization (FISH) indicated that multiple wheat chromosomes were involved in the translocation events, including chromosome 2A, 3A, 5A, 7A, 3B, 5B, 7B, 3D and 7D...
2016: PloS One
https://www.readbyqxmd.com/read/27436264/copy-number-variations-in-375-patients-with-oesophageal-atresia-and-or-tracheoesophageal-fistula
#11
Erwin Brosens, Florian Marsch, Elisabeth M de Jong, Hitisha P Zaveri, Alina C Hilger, Vera Gisela Choinitzki, Alice Hölscher, Per Hoffmann, Stefan Herms, Thomas M Boemers, Benno M Ure, Martin Lacher, Michael Ludwig, Bert H Eussen, Robert M van der Helm, Hannie Douben, Diane Van Opstal, Rene M H Wijnen, H Berna Beverloo, Yolande van Bever, Alice S Brooks, Hanneke IJsselstijn, Daryl A Scott, Johannes Schumacher, Dick Tibboel, Heiko Reutter, Annelies de Klein
Oesophageal atresia (OA) with or without tracheoesophageal fistula (TOF) are rare anatomical congenital malformations whose cause is unknown in over 90% of patients. A genetic background is suggested, and among the reported genetic defects are copy number variations (CNVs). We hypothesized that CNVs contribute to OA/TOF development. Quantifying their prevalence could aid in genetic diagnosis and clinical care strategies. Therefore, we profiled 375 patients in a combined Dutch, American and German cohort via genomic microarray and compared the CNV profiles with their unaffected parents and published control cohorts...
December 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27238810/eficacia-del-entrenamiento-diario-de-una-repetici%C3%A3-n-de-m%C3%A3-ximo-peso-en-levantadores-de-pesas-bien-entrenados-una-serie-de-casos
#12
Michael C Zourdos, Chad Dolan, Justin M Quiles, Alex Klemp, Edward Jo, Jeremy P Loenneke, Rocky Blanco, Michael Whitehurst
No abstract text is available yet for this article.
March 25, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27125607/-percutaneous-coronary-intervention-in-navarre-outcomes-of-a-low-volume-centre
#13
M Artaiz, N Salterain, A Fernández Montero, A Hernández-Hernández, J P Canepa Leite, J Calabuig Nogués
BACKGROUND: Percutaneous coronary intervention (PCI)is currently a basic therapeutic option in patients with coronary artery disease. To carry this out specialists must be trained and accredited. It is known that the number of procedures performed each year influences results. We suggest that some low volume centres may also get good results. METHODS: Prospective analysis of clinical features and immediate results obtained in our centre following PCI performed between 2006 and 2012 and retrospective analysis of overall survival, outcome-free survival and restenosis in patients treated between 2006 and 2009...
2016: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/26676803/developmental-endothelial-locus-1-modulates-platelet-monocyte-interactions-and-instant-blood-mediated-inflammatory-reaction-in-islet-transplantation
#14
Ioannis Kourtzelis, Klara Kotlabova, Jong-Hyung Lim, Ioannis Mitroulis, Anaisa Ferreira, Lan-Sun Chen, Bettina Gercken, Anja Steffen, Elisabeth Kemter, Anne Klotzsche-von Ameln, Claudia Waskow, Kavita Hosur, Antonios Chatzigeorgiou, Barbara Ludwig, Eckhard Wolf, George Hajishengallis, Triantafyllos Chavakis
Platelet-monocyte interactions are strongly implicated in thrombo-inflammatory injury by actively contributing to intravascular inflammation, leukocyte recruitment to inflamed sites, and the amplification of the procoagulant response. Instant blood-mediated inflammatory reaction (IBMIR) represents thrombo-inflammatory injury elicited upon pancreatic islet transplantation (islet-Tx), thereby dramatically affecting transplant survival and function. Developmental endothelial locus-1 (Del-1) is a functionally versatile endothelial cell-derived homeostatic factor with anti-inflammatory properties, but its potential role in IBMIR has not been previously addressed...
April 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/26603257/identification-of-developmental-endothelial-locus-1-on-circulating-extracellular-vesicles-as-a-novel-biomarker-for-early-breast-cancer-detection
#15
Pyong-Gon Moon, Jeong-Eun Lee, Young-Eun Cho, Soo Jung Lee, Jin Hyang Jung, Yee Soo Chae, Han-Ik Bae, Young-Bum Kim, In-San Kim, Ho Yong Park, Moon-Chang Baek
PURPOSE: Currently, there are no molecular biomarkers for the early detection of breast cancer. This study focused on identifying surface proteins found on circulating extracellular vesicles (EVs) for detecting early-stage breast cancer. EXPERIMENTAL DESIGN: Circulating EVs, isolated from the plasma of 10 patients with breast cancer (stages I and II) and 5 healthy controls, were analyzed using LC-MS/MS. Developmental endothelial locus-1 protein (Del-1) was selected as a candidate biomarker...
April 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26554893/regulation-of-tissue-infiltration-by-neutrophils-role-of-integrin-%C3%AE-3%C3%AE-1-and-other-factors
#16
REVIEW
Pallavi Subramanian, Ioannis Mitroulis, George Hajishengallis, Triantafyllos Chavakis
PURPOSE OF REVIEW: Neutrophils have traditionally been viewed in the context of acute infection and inflammation forming the first line of defense against invading pathogens. Neutrophil trafficking to the site of inflammation requires adhesion and transmigration through blood vessels, which is orchestrated by adhesion molecules, such as β2 and β1-integrins, chemokines, and cytokines. The review focuses on recent advances in understanding the regulators of neutrophil recruitment during inflammation in both acute and chronic settings...
January 2016: Current Opinion in Hematology
https://www.readbyqxmd.com/read/26545781/del-1-overexpression-potentiates-lung-cancer-cell-proliferation-and-invasion
#17
Seung-Hwan Lee, Dong-Young Kim, Feifeng Jing, Hyesoon Kim, Chae-Ok Yun, Deok-Jong Han, Eun Young Choi
Developmental endothelial locus-1 (Del-1) is an endogenous anti-inflammatory molecule that is highly expressed in the lung and the brain and limits leukocyte migration to these tissues. We previously reported that the expression of Del-1 is positively regulated by p53 in lung endothelial cells. Although several reports have implicated the altered expression of Del-1 gene in cancer patients, little is known about its role in tumor cells. We here investigated the effect of Del-1 on the features of human lung carcinoma cells...
December 4, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26390397/gait-pattern-and-cognitive-performance-during-treadmill-walking-in-parkinson-disease
#18
RANDOMIZED CONTROLLED TRIAL
Helena Fernández-Lago, Olalla Bello, Virginia López-Alonso, José Andrés Sánchez, Luis Morenilla, Miguel Ángel Fernández-del-Olmo
OBJECTIVE: The aim of this study was to explore whether attentional demands are involved in gait improvements in Parkinson disease (PD) patients when they walk on a treadmill. DESIGN: Nineteen individuals with idiopathic PD and 19 age-matched healthy controls participated in this study. Participants walked on a treadmill and on overground under single task (walk only) and dual task (walk performing a simultaneous cognitive task) conditions. The dual-task paradigm was used to reveal the attention allocation behavior...
November 2015: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/26388464/extremity-cone-beam-ct-for-evaluation-of-medial-tibiofemoral-osteoarthritis-initial-experience-in-imaging-of-the-weight-bearing-and-non-weight-bearing-knee
#19
Gaurav K Thawait, Shadpour Demehri, Abdullah AlMuhit, Wojciech Zbijweski, John Yorkston, Filippo Del Grande, Bashir Zikria, John A Carrino, Jeffrey H Siewerdsen
PURPOSE: To investigate differences in joint space width (JSW) and meniscal extrusion (ME) between non-weight bearing (NWB) and weight bearing (WB) examinations of knee joints with medial compartment osteoarthritis (OA) using a cone-beam CT (CBCT) extremity imaging system. MATERIALS AND METHODS: In this IRB approved prospective study, informed consent was obtained for 17 patients symptomatic for OA (11 F,6 M; 31-78 years, mean 56 years) and 18 asymptomatic controls (0 F,18 M; 29-48 years, mean 38...
December 2015: European Journal of Radiology
https://www.readbyqxmd.com/read/26387949/pka-phosphorylates-the-atpase-inhibitory-factor-1-and-inactivates-its-capacity-to-bind-and-inhibit-the-mitochondrial-h-atp-synthase
#20
Javier García-Bermúdez, María Sánchez-Aragó, Beatriz Soldevilla, Araceli Del Arco, Cristina Nuevo-Tapioles, José M Cuezva
The mitochondrial H(+)-ATP synthase synthesizes most of cellular ATP requirements by oxidative phosphorylation (OXPHOS). The ATPase Inhibitory Factor 1 (IF1) is known to inhibit the hydrolase activity of the H(+)-ATP synthase in situations that compromise OXPHOS. Herein, we demonstrate that phosphorylation of S39 in IF1 by mitochondrial protein kinase A abolishes its capacity to bind the H(+)-ATP synthase. Only dephosphorylated IF1 binds and inhibits both the hydrolase and synthase activities of the enzyme...
September 29, 2015: Cell Reports
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