keyword
https://read.qxmd.com/read/38497112/roles-for-integrin-%C3%AE-3%C3%AE-1-in-regulating-the-ability-of-epithelial-cells-to-modulate-the-microenvironment-during-normal-and-pathological-tissue-remodeling
#1
REVIEW
Rakshitha Pandulal Miskin, C Michael DiPersio
Integrin receptors for the extracellular matrix activate intracellular signaling pathways that are critical for tissue development, homeostasis, and regeneration/repair, and their loss or dysregulation contributes to many developmental defects and tissue pathologies. This review will focus on tissue remodeling roles for integrin α3β1, a receptor for laminins found in the basement membranes that underlie epithelial cell layers. As a paradigm, we will discuss literature that supports a role for α3β1 in promoting ability of epidermal keratinocytes to modify their tissue microenvironment during skin development, wound healing or tumorigenesis...
March 18, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38495100/neutrophil-elastase-as-a-versatile-cleavage-enzyme-for-activation-of-%C3%AE-v%C3%AE-3-integrin-targeted-small-molecule-drug-conjugates-with-different-payload-classes-in-the-tumor-microenvironment
#2
JOURNAL ARTICLE
Anne-Sophie Rebstock, Mareike Wiedmann, Beatrix Stelte-Ludwig, Harvey Wong, Amy J Johnson, Raquel Izumi, Ahmed Hamdy, Hans-Georg Lerchen
Introduction: The development of bioconjugates for the targeted delivery of anticancer agents is gaining momentum after recent success of antibody drug conjugates (ADCs) in the clinic. Smaller format conjugates may have several advantages including better tumor penetration; however, cellular uptake and trafficking may be substantially different from ADCs. To fully leverage the potential of small molecule drug conjugates (SMDCs) with potent binding molecules mediating tumor homing, novel linker chemistries susceptible for efficient extracellular activation and payload release in the tumor microenvironment (TME) need to be explored...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38494238/preparation-of-an-injectable-and-photocurable-carboxymethyl-cellulose-hydroxyapatite-composite-and-its-application-in-cranial-regeneration
#3
JOURNAL ARTICLE
He Qiu, Jing Wang, Hong Hu, Lu Song, Zhanhong Liu, Yang Xu, Shuo Liu, Xiangdong Zhu, Hang Wang, Chongyun Bao, Hai Lin
Limited bone regeneration, uncontrollable degradation rate, mismatched defect zone and poor operability have plagued the reconstruction of irregular bone defect by tissue-engineered materials. A combination of biomimetic scaffolds with hydroxyapatite has gained great popularity in promoting bone regeneration. Therefore, we designed an injectable, photocurable and in-situ curing hydrogel by methacrylic anhydride -modified carboxymethyl cellulose (CMC-MA) loading with spherical hydroxyapatite (HA) to highly simulate the natural bony matrix and match any shape of damaged tissue...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38493497/bioengineered-hydrogels-recapitulate-fibroblast-heterogeneity-in-cancer
#4
JOURNAL ARTICLE
Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N Gopalakrishna Iyer, Eliza Li Shan Fong
Recently mapped transcriptomic landscapes reveal the extent of heterogeneity in cancer-associated fibroblasts (CAFs) beyond previously established single-gene markers. Functional analyses of individual CAF subsets within the tumor microenvironment are critical to develop more accurate CAF-targeting therapeutic strategies. However, there is a lack of robust preclinical models that reflect this heterogeneity in vitro. In this study, single-cell RNA sequencing datasets acquired from head and neck squamous cell carcinoma tissues to predict microenvironmental and cellular features governing individual CAF subsets are leveraged...
March 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38492733/developmental-dopaminergic-signaling-modulates-neural-circuit-formation-and-contributes-to-autism-spectrum-disorder-asd-related-phenotypes
#5
JOURNAL ARTICLE
Xiaojuan Lu, Yixing Song, Jiaqi Wang, Yunyun Cai, Siwan Peng, Jiaqi Lin, Biqin Lai, Junjie Sun, Tianqing Liu, Gang Chen, Lingyan Xing
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with a complex etiology. Recent evidence suggests that dopamine plays a crucial role in neural development. However, it remains unclear whether and how disrupted dopaminergic signaling during development contributes to ASD. In this study, human brain RNA-seq transcriptome analysis revealed a significant correlation between changes in dopaminergic signaling pathways and neural developmental signaling in ASD patients. In the zebrafish model, disrupted developmental dopaminergic signaling led to neural circuit abnormalities and behavior reminiscent of autism...
March 14, 2024: American Journal of Pathology
https://read.qxmd.com/read/38492223/neutrophil-inflicted-vasculature-damage-suppresses-immune-mediated-optic-nerve-regeneration
#6
JOURNAL ARTICLE
Ryan Passino, Matthew C Finneran, Hannah Hafner, Qian Feng, Lucas D Huffman, Xiao-Feng Zhao, Craig N Johnson, Riki Kawaguchi, Juan A Oses-Prieto, Alma L Burlingame, Daniel H Geschwind, Larry I Benowitz, Roman J Giger
In adult mammals, injured retinal ganglion cells (RGCs) fail to spontaneously regrow severed axons, resulting in permanent visual deficits. Robust axon growth, however, is observed after intra-ocular injection of particulate β-glucan isolated from yeast. Blood-borne myeloid cells rapidly respond to β-glucan, releasing numerous pro-regenerative factors. Unfortunately, the pro-regenerative effects are undermined by retinal damage inflicted by an overactive immune system. Here, we demonstrate that protection of the inflamed vasculature promotes immune-mediated RGC regeneration...
March 14, 2024: Cell Reports
https://read.qxmd.com/read/38492186/immunomodulatory-and-anti-inflammatory-effects-of-vitamin-a-and-tryptophan-on-monocyte-derived-dendritic-cells-stimulated-with-gliadin-in-celiac-disease-patients
#7
JOURNAL ARTICLE
Fatemeh Asgari, Abdolrahim Nikzamir, Kaveh Baghaei, Siamak Salami, Andrea Masotti, Mohammad Rostami-Nejad
Celiac Disease (CeD) is an autoimmune disorder with various symptoms upon gluten exposure. Dendritic cells (DCs) play a crucial role in gliadin-induced inflammation. Vitamin A (retinol; Ret) and its metabolite, retinoic acid (RA), along with tryptophan (Trp) and its metabolite, kynurenic acid (KYNA), are known to influence the immune function of DCs and enhance their tolerogenicity. This research aims to assess the impact of gliadin on DC maturation and the potential of vitamin A and tryptophan to induce immune tolerance in DCs...
March 16, 2024: Inflammation
https://read.qxmd.com/read/38491294/association-between-thyroid-disorders-and-extra-thyroidal-cancers-a-review
#8
REVIEW
Xin Jia, Jingru Li, Zongliang Jiang
Thyroid hormone has been shown to have both tumor-promoting and tumor-suppressing actions, which has led to significant debate over its involvement in the development of cancer. Proliferation, apoptosis, invasiveness, and angiogenesis are all aspects of cancer that are affected by the thyroid hormones T3 and T4, according to research conducted in animal models and in vitro experiments. The effects of thyroid hormones on cancer cells are mediated by many non-genomic mechanisms, one of which involves the activation of the plasma membrane receptor integrin αvβ3...
March 15, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38491216/endothelial-cell-derived-extracellular-vesicles-expressing-surface-vcam1-promote-sepsis-related-acute-lung-injury-by-targeting-and-reprogramming-monocytes
#9
JOURNAL ARTICLE
Lu Wang, Ying Tang, Jiajian Tang, Xu Liu, Shuangfeng Zi, Songli Li, Hanbing Chen, Airan Liu, Wei Huang, Jianfeng Xie, Ling Liu, Jie Chao, Haibo Qiu
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common life-threatening syndrome with no effective pharmacotherapy. Sepsis-related ARDS is the main type of ARDS and is more fatal than other types. Extracellular vesicles (EVs) are considered novel mediators in the development of inflammatory diseases. Our previous research suggested that endothelial cell-derived EVs (EC-EVs) play a crucial role in ALI/ARDS development, but the mechanism remains largely unknown. Here, we demonstrated that the number of circulating EC-EVs was increased in sepsis, exacerbating lung injury by targeting monocytes and reprogramming them towards proinflammatory macrophages...
March 2024: Journal of Extracellular Vesicles
https://read.qxmd.com/read/38490483/zirconium-containing-nanoscale-coordination-polymers-for-positron-emission-tomography-and-fluorescence-guided-cargo-delivery-to-triple-negative-breast-tumors
#10
JOURNAL ARTICLE
Yan-Ping Li, Zi-Wen Pan, Yan-Jun Jiang, Ya-Yun Peng, Ting Cai, Hao Hong, Xiao-Feng Wang
Nanoscale coordination polymer (NCP) is a class of hybrid materials formed by self-assembly of metal ions and organic ligands through coordination. The applications of NCP in biomedicine are quite extensive due to the diversity choice of metal ions and organic ligands. Here we designed Zr-P1 NCP based on Zr4+ selected as metal ion nodes and tetrakis(4-carboxyphenyl) ethylene as bridging ligands. Zr-P1 NCP was modified with functionalized pyrene derived polyethylene glycol (Py-PAA-PEG-Mal) on the surface and further conjugated with cRGD for active targeting of integrin αv β3 overexpressed in triple-negative breast cancer...
March 13, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38490094/n-linked-%C3%AE-2-6-sialylation-of-integrin-%C3%AE-1-by-the-sialyltransferase-st6gal1-promotes-cell-proliferation-and-stemness-in-gestational-trophoblastic-disease
#11
JOURNAL ARTICLE
Jianwei Liu, Xinyue Dong, Ru Xie, Ying Tang, Aline M Thomas, Shen Li, Shuai Liu, Ming Yu, Huamin Qin
INTRODUCTION: Gestational trophoblastic disease (GTD) encompasses a spectrum of rare pre-malignant and malignant entities originating from trophoblastic tissue, including partial hydatidiform mole, complete hydatidiform mole and choriocarcinoma. β-galactoside α2,6 sialyltransferase 1 (ST6Gal1), the primary sialyltransferase responsible for the addition of α2,6 sialic acids, is strongly associated with the occurrence and development of several tumor types. However, the role of ST6Gal1/α2,6 -sialylation of trophoblast cells in GTD is still not well understood...
March 11, 2024: Placenta
https://read.qxmd.com/read/38489969/fibrinogen-deposition-promotes-neuroinflammation-and-fibrin-derived-%C3%AE-377-395-peptide-ameliorates-neurological-deficits-after-ischemic-stroke
#12
JOURNAL ARTICLE
Lu Han, Yaying Song, Weiwei Xiang, Ze Wang, Yishu Wang, Xiajun Zhou, De-Sheng Zhu, Yangtai Guan
BACKGROUND: Fibrin(ogen) deposition in the central nervous system (CNS) contributes to neuropathological injury; however, its role in ischemic stroke is unknown. In this study, we identified fibrinogen as a novel proinflammatory regulator of post-stroke neuroinflammation and revealed the neuro-protection effect of fibrin-derived γ377-395 peptide in stroke. METHODS: Fibrinogen depletion and fibrinogen-derived γ377-395 peptide treatment were performed 2 h after establishing a permanent middle cerebral artery occlusion (pMCAO) model...
March 14, 2024: International Immunopharmacology
https://read.qxmd.com/read/38489236/semaphorin-7a-coordinates-neutrophil-response-during-pulmonary-inflammation-and-sepsis
#13
JOURNAL ARTICLE
Tiago Folgosa Granja, David Köhler, Linyan Tang, Philipp Burkard, Claudia Eggstein, Katherina Hemmen, Katrin G Heinze, Ka-Lin Heck-Swain, Michael Koeppen, Sven Günther, Maximilian Klaus Blaha, Harry Magunia, Maximilian Bamberg, Franziska Magdalena Konrad, Kristian-Christos Ngamsri, Anika Fuhr, Marius Keller, Alice Bernard, Helene Haeberle, Tamam Bakchoul, Alexander Zarbock, Bernhard Nieswandt, Peter Rosenberger
RATIONALE: Pulmonary defense mechanisms are critical for host integrity during pneumonia and sepsis. This defense is fundamentally dependent on the activation of neutrophils during the innate immune response. Recent work has shown that Semaphorin 7A (Sema7A) holds significant impact on platelet function, yet its role on neutrophil function within the lung is not well understood. OBJECTIVE: To identify the role of Sema7A during pulmonary inflammation and sepsis. MEASUREMENTS AND MAIN RESULTS: In ARDS patients we were able to show a correlation between Sema7A and oxygenation levels...
March 15, 2024: Blood Advances
https://read.qxmd.com/read/38488682/exploring-the-impact-of-itgb2-on-glioma-progression-and-treatment-insights-from-non-apoptotic-cell-death-and-immunotherapy
#14
JOURNAL ARTICLE
Junhong Zhuang, Changfeng Miao, Chao Liu, Biying Zeng, Linwang Hu, Jun Peng, Ying Xia, Zigui Chen
In the realm of glioma treatment, our groundbreaking research has uncovered the pivotal role of Integrin Beta 2 (ITGB2) in non-apoptotic cell death and its profound implications for immunotherapy efficacy. Gliomas, known for their aggressive and infiltrative nature, demand innovative therapeutic strategies for improved patient outcomes. Our study bridges a critical gap by examining the interplay between non-apoptotic cell death and immunotherapy response in gliomas. Through comprehensive analysis of ten diverse glioma datasets, we developed a unique death enrichment score and identified ITGB2 as a significant risk marker...
March 15, 2024: Environmental Toxicology
https://read.qxmd.com/read/38488009/cytoplasmic-retention-of-the-dna-rna-binding-protein-fus-ameliorates-organ-fibrosis-in-mice
#15
JOURNAL ARTICLE
Manuel Chiusa, Youngmin A Lee, Ming-Zhi Zhang, Raymond C Harris, Taylor Sherrill, Volkhard Lindner, Craig R Brooks, Gang Yu, Agnes B Fogo, Charles R Flynn, Jozef Zienkiewicz, Jacek Hawiger, Roy Zent, Ambra Pozzi
Uncontrolled accumulation of extracellular matrix leads to tissue fibrosis and loss of organ function. We previously demonstrated in vitro that the DNA/RNA-binding protein fused in sarcoma (FUS) promotes fibrotic responses by translocating to the nucleus, where it initiates collagen gene transcription. However, it is still not known whether FUS is profibrotic in vivo and whether preventing its nuclear translocation might inhibit development of fibrosis following injury. We now demonstrate that levels of nuclear FUS are significantly increased in mouse models of kidney and liver fibrosis...
March 15, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38488000/tgf-%C3%AE-controls-alveolar-type-1-epithelial-cell-plasticity-and-alveolar-matrisome-gene-transcription-in-mice
#16
JOURNAL ARTICLE
Danielle A Callaway, Ian J Penkala, Su Zhou, Jonathan J Knowlton, Fabian Cardenas-Diaz, Apoorva Babu, Michael P Morley, Mariana Lopes, Benjamin A Garcia, Edward E Morrisey
Premature birth disrupts normal lung development and places infants at risk for bronchopulmonary dysplasia (BPD), a disease disrupting lung health throughout the life of an individual and that is increasing in incidence. The TGF-β superfamily has been implicated in BPD pathogenesis, however, what cell lineage it impacts remains unclear. We show that TGFbr2 is critical for alveolar epithelial (AT1) cell fate maintenance and function. Loss of TGFbr2 in AT1 cells during late lung development leads to AT1-AT2 cell reprogramming and altered pulmonary architecture, which persists into adulthood...
January 11, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38487529/skap2-acts-downstream-of-cd11b-cd18-and-regulates-neutrophil-effector-function
#17
JOURNAL ARTICLE
Panagiota Bouti, Bart J A M Klein, Paul J H Verkuijlen, Karin Schornagel, Floris P J van Alphen, Kees-Karel H Taris, Maartje van den Biggelaar, Arie J Hoogendijk, Robin van Bruggen, Taco W Kuijpers, Hanke L Matlung
BACKGROUND: The importance of CD11b/CD18 expression in neutrophil effector functions is well known. Beyond KINDLIN3 and TALIN1, which are involved in the induction of the high-affinity binding CD11b/CD18 conformation, the signaling pathways that orchestrate this response remain incompletely understood. METHOD: We performed an unbiased screening method for protein selection by biotin identification (BioID) and investigated the KINDLIN3 interactome...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38487345/research-progress-of-periostin-and-osteoporosis
#18
REVIEW
Chuyue Yuan, Junyan Li
Periostin, as a unique extracellular matrix, is mainly produced during ontogeny and in adult connective tissues that bear mechanical loads, such as heart valves, skin, periodontal ligaments, tendons, and bones. By binding to the integrin on the cell surface and activating Wnt/β-catenin, NF-κB, Fak and other signaling pathways, it regulates the tissues in vivo positively or negatively, and also has different effects on the occurrence and development of various diseases. Periostin is an important factor, which can promote cell proliferation, stimulate tissue repair and maintain the integrity of the structure and function of connective tissue...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38486751/exosomes-derived-from-itgb1-modified-telocytes-alleviates-lps-induced-inflammation-and-oxidative-stress-through-yap1-ros-axis
#19
JOURNAL ARTICLE
Ruixue Qi, Yuchao Wang, Furong Yan, Jinlong Zhong
AIMS: Previous studies have demonstrated a significant upregulation of Integrin Beta 1 (ITGB1) in Telocytes. This study aims to explore the roles and underlying mechanisms of ITGB1 in inflammation and oxidative stress following Lipo-polysaccharide (LPS) administration in Telocytes. METHODS: We observed an increase in reactive oxygen species (ROS) production, accompanied by a reduction in ITGB1 levels post-LPS treatment. RESULTS: Notably, inhibiting ROS synthesis markedly reduced LPS-induced ITGB1 expression...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38486484/retraction-insulin-like-growth-factor-1-induces-adhesion-and-migration-in-human-multiple-myeloma-cells-via-activation-of-%C3%AE-1-integrin-and-phosphatidylinositol-3-kinase-akt-signaling
#20
JOURNAL ARTICLE
Yu-Tzu Tai, Klaus Podar, Laurence Catley, Yu-Hua Tseng, Masaharu Akiyama, Reshma Shringarpure, Renate Burger, Teru Hideshima, Dharminder Chauhan, Nicholas Mitsiades, Paul Richardson, Nikhil C Munshi, C Ronald Kahn, Constantine Mitsiades, Kenneth C Anderson
No abstract text is available yet for this article.
March 15, 2024: Cancer Research
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