Tiago Folgosa Granja, David Köhler, Linyan Tang, Philipp Burkard, Claudia Eggstein, Katherina Hemmen, Katrin G Heinze, Ka-Lin Heck-Swain, Michael Koeppen, Sven Günther, Maximilian Klaus Blaha, Harry Magunia, Maximilian Bamberg, Franziska Magdalena Konrad, Kristian-Christos Ngamsri, Anika Fuhr, Marius Keller, Alice Bernard, Helene Haeberle, Tamam Bakchoul, Alexander Zarbock, Bernhard Nieswandt, Peter Rosenberger
RATIONALE: Pulmonary defense mechanisms are critical for host integrity during pneumonia and sepsis. This defense is fundamentally dependent on the activation of neutrophils during the innate immune response. Recent work has shown that Semaphorin 7A (Sema7A) holds significant impact on platelet function, yet its role on neutrophil function within the lung is not well understood. OBJECTIVE: To identify the role of Sema7A during pulmonary inflammation and sepsis. MEASUREMENTS AND MAIN RESULTS: In ARDS patients we were able to show a correlation between Sema7A and oxygenation levels...
March 15, 2024: Blood Advances