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Iron source

Brian Chiou, Emma H Neal, Aaron B Bowman, Ethan S Lippmann, Ian A Simpson, James R Connor
Iron delivery to the brain is essential for multiple neurological processes such as myelination, neurotransmitter synthesis, and energy production. Loss of brain iron homeostasis is a significant factor in multiple neurological disorders. Understanding the mechanism by which the transport of iron across the blood-brain barrier (BBB) is regulated is crucial to address the impact of iron deficiency on brain development and excessive accumulation of iron in neurodegenerative diseases. Using induced pluripotent stem cell (iPSC)-derived brain endothelial cells (huECs) as a human BBB model, we demonstrate the ability of transferrin, hepcidin, and DMT1 to impact iron transport and release...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
Sandra Peherstorfer, Hans Henning Brewitz, Ajay Abisheck Paul George, Amelie Wißbrock, Jana Maria Adam, Lutz Schmitt, Diana Imhof
BACKGROUND: Tight regulation of heme homeostasis is a critical mechanism in pathogenic bacteria since heme functions as iron source and prosthetic group, but is also toxic at elevated concentrations. Hemolysin-activating lysine-acyltransferase (HlyC) from Escherichia coli is crucial for maturation of hemolysin A, which lyses several mammalian cells including erythrocytes liberating large amounts of heme for bacterial uptake. A possible impact and functional consequences of the released heme on events employing bacterial HlyC have remained unexplored...
June 14, 2018: Biochimica et Biophysica Acta
Aisha Al-Asfar, Zoya Zaheer, Elham Shafik Aazam
Silver-iron bimetallic nanoparticles (BMNPs) were synthesized by using AgNO3 and Fe(NO3 )3 as an Ag/Fe source in presence of Palm dates fruit. Upon addition of extract to a solution of Ag+ and Fe3+ , a prefect transparent stable dark brown color appears with in a few minuets at room temperature. In order to conform the nature of resulting color, UV-visible spectroscopy, transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDX) techniques were used. The absence of surface plasmon resonance (SPR) peaks in the entire UV-visible region suggests the formation of silvercore -ironshell BMNPs...
June 6, 2018: Journal of Photochemistry and Photobiology. B, Biology
Fernando Uriel Rojas-Rojas, Anuar Salazar-Gómez, María Elena Vargas-Díaz, María Soledad Vásquez-Murrieta, Ann M Hirsch, René De Mot, Maarten G K Ghequire, J Antonio Ibarra, Paulina Estrada-de Los Santos
The Burkholderia cepacia complex (Bcc) comprises a group of 24 species, many of which are opportunistic pathogens of immunocompromised patients and also are widely distributed in agricultural soils. Several Bcc strains synthesize strain-specific antagonistic compounds. In this study, the broad killing activity of B. cenocepacia TAtl-371, a Bcc strain isolated from the tomato rhizosphere, was characterized. This strain exhibits a remarkable antagonism against bacteria, yeast and fungi including other Bcc strains, multidrug-resistant human pathogens and plant pathogens...
June 15, 2018: Microbiology
Kai Yu, Yiqun Gan, Aiguo Zhou, Chongxuan Liu, Yanhua Duan, Li Han, Yanan Zhang
Groundwater arsenic contamination is a common environmental problem that threatens the health of over 100 million people globally. Apparent seasonal fluctuations in groundwater arsenic concentrations have been reported in various locations worldwide, including the Jianghan Plain, central China. This phenomenon has been attributed to shifts in redox conditions induced by seasonal incursions of surface water. However, it is not clear what processes during the incursion lead to changes in the redox conditions and what is the source of the organic carbon driving these processes...
May 30, 2018: Chemosphere
Ogbiye A Samuel, Emenike C PraiseGod, Tenebe I Theophilus, Kafi C Omolola
Constant drinking water monitoring schemes are necessary because hazardous substances tend to enter water bodies through geodetic and anthropogenic sources. The main goal of this study was to evaluate the human health risk assessment posed by high fluoride and iron concentration in tap water used for domestic activities and consumption. In this study, the concentration of fluoride in tap water varied at different locations, ranging from 0.48 mg/L to 1.84 mg/L with an average value of 1.23 mg/L while that of iron ranged from 0...
June 2018: Data in Brief
Bożena Muszyńska, Agata Krakowska, Jan Lazur, Barbara Jękot, Łukasz Zimmer, Agnieszka Szewczyk, Katarzyna Sułkowska-Ziaja, Ewa Poleszak, Włodzimierz Opoka
Chlorella vulgaris Beijerinck is a spherical, green alga belonging to the genus Chlorella and family Chlorellaceae. It has high nutritional value and shows multiple biological effects. Dietary supplements that contain extracts of C. vulgaris are sold in the form of tablets, capsules, powders, and aqueous solutions. To the best of our knowledge, this is the first study to determine the content of bioelements (zinc, iron, and magnesium), phenolic compounds, and lutein before and after incubation with artificial digestive juices from preparations containing C...
2018: Journal of Applied Phycology
Cécile Guieu, Sophie Bonnet, Anne Petrenko, Christophe Menkes, Valérie Chavagnac, Karine Desboeufs, Christophe Maes, Thierry Moutin
In the Western Tropical South Pacific, patches of high chlorophyll concentrations linked to the occurrence of N2 -fixing organisms are found in the vicinity of volcanic islands. The survival of these organisms relies on a high bioavailable iron supply whose origin and fluxes remain unknown. Here, we measured high dissolved iron (DFe) concentrations (up to 66 nM) in the euphotic layer, extending zonally over 10 degrees longitude (174 E-175 W) at ∼20°S latitude. DFe atmospheric fluxes were at the lower end of reported values of the remote ocean and could not explain the high DFe concentrations measured in the water column in the vicinity of Tonga...
June 13, 2018: Scientific Reports
Alexander Crits-Christoph, Spencer Diamond, Cristina N Butterfield, Brian C Thomas, Jillian F Banfield
In soil ecosystems, microorganisms produce diverse secondary metabolites such as antibiotics, antifungals and siderophores that mediate communication, competition and interactions with other organisms and the environment1,2 . Most known antibiotics are derived from a few culturable microbial taxa 3 , and the biosynthetic potential of the vast majority of bacteria in soil has rarely been investigated 4 . Here we reconstruct hundreds of near-complete genomes from grassland soil metagenomes and identify microorganisms from previously understudied phyla that encode diverse polyketide and nonribosomal peptide biosynthetic gene clusters that are divergent from well-studied clusters...
June 13, 2018: Nature
Andrew Wagner, Stephen Norris, Payel Chatterjee, Paul F Morris, Hans Wildschutte
Seedling root rot of soybeans caused by the host-specific pathogen Phytophthora sojae , and a large number of Pythium species, is an economically important disease across the Midwest United States that negatively impacts soybean yields. Research on biocontrol strategies for crop pathogens has focused on compounds produced by microbes from soil, however, recent studies suggest that aquatic bacteria express distinct compounds that efficiently inhibit a wide range of pathogens. Based on these observations, we hypothesized that freshwater strains of pseudomonads might be producing novel antagonistic compounds that inhibit the growth of oomycetes...
2018: Frontiers in Microbiology
A Tanskanen, M Karppinen
Iron terephthalate coordination network thin films can be fabricated using the state-of-the-art gas-phase atomic/molecular layer deposition (ALD/MLD) technique in a highly controlled manner. Iron is an Earth-abundant and nonhazardous transition metal, and with its rich variety of potential applications an interesting metal constituent for the inorganic-organic coordination network films. Our work underlines the role of the metal precursor used when aiming at in-situ ALD/MLD growth of crystalline inorganic-organic thin films...
June 12, 2018: Scientific Reports
Daniel Turiel-Fernández, Jörg Bettmer, Maria Montes-Bayón
The therapy with nanocompounds is widely used to treat Fe deficiency and an emerging trend to inhibit tumor growth. The present work aims to address the management of different FeONP, comparing sucrose covered FeONP and Fe nanoparticles in the form of the ferritin with non-particulated inorganic Fe (II) by enterocytes-like colon cancer cell lines (Caco-2 and HT-29). Iron uptake results revealed significantly higher Fe incorporation in the case of nanoparticulated Fe, first in the form of FeONP and second in the form of ferritin with respect to inorganic Fe (II)...
September 2018: Journal of Trace Elements in Medicine and Biology
Houqi Liu, Guijian Liu, Shanshan Wang, Chuncai Zhou, Zijiao Yuan, Chunnian Da
This study measured the concentrations of eight heavy metals, including copper (Cu), zinc (Zn), lead (Pb), chromium (Cr), cadmium (Cd), iron (Fe), manganese (Mn) and nickel (Ni), and the stable isotope ratios of δ13 C and δ15 N in 129 fish samples collected from the Yellow River Estuary (YRE) of China. Accumulation characteristics and possible sources of these heavy metals (HMs) were analyzed. The levels of HMs presented high variations among sampling sites, higher concentrations of ∑HMs were observed at the sites closest to the estuary...
June 5, 2018: Chemosphere
Bo Wang, Dunsheng Xia, Ye Yu, Hong Chen, Jia Jia
We studied the magnetic properties and trace element concentrations (Cr, Cu, Fe, Mn, Pb, Ti, V, Zn) of urban topsoils from 111 urban sites in a large REE-Nb-Fe mining and smelting city, Baotou, Inner Mongolia, China. The results show that pseudo-single domain and multi-domain magnetite dominates the magnetic properties of the soil samples, and the magnetic concentration parameters show a large positive anomaly near the Baotou iron and steel works. The average contents of all trace metals exceeded their background level in soils in Inner Mongolia, except for Pb...
June 9, 2018: Science of the Total Environment
Riyadh A Alzaheb, Norah Alatawi, Khawla A Daoud, Naema Altawil
BACKGROUND: Establishing understanding of infants' dietary intakes can support interventions to improve their diets and overall health. Because information on the dietary intakes of infants aged ≤12 months in Saudi Arabia is scarce, this study examined the diets of infants aged 6 and 12 months in Saudi Arabia and determined their main dietary sources of total energy and macronutrients. METHODS: A crosssectional dietary survey employing a single 24-hour recall was performed between May and December 2015 with a sample of mothers of 278 healthy 6-month-old and 259 12-month-old infants...
June 12, 2018: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Markus Kubin, Jan Kern, Meiyuan Guo, Erik Källman, Rolf Mitzner, Vittal K Yachandra, Marcus Lundberg, Junko Yano, Philippe Wernet
X-ray induced sample damage can impede electronic and structural investigations of radiation-sensitive samples studied with X-rays. Here we quantify dose-dependent sample damage to the prototypical MnIII(acac)3 complex in solution and at room temperature for the soft X-ray range, using X-ray absorption spectroscopy at the Mn L-edge. We observe the appearance of a reduced MnII species as the X-ray dose is increased. We find a half-damage dose of 1.6 MGy and quantify a spectroscopically tolerable dose on the order of 0...
June 11, 2018: Physical Chemistry Chemical Physics: PCCP
Yingli Song, Xiaolan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu
Group A Streptococcus (GAS) requires iron for growth, and heme is an important source of iron for GAS. Streptococcus heme transporter A (HtsA) is the lipoprotein component of the GAS heme-specific ABC transporter (HtsABC). The objective of this study is to examine the contribution of HtsABC to virulence and host interaction of hypervirulent M1T1 GAS using an isogenic htsA deletion mutant (Δ htsA ). The htsA deletion exhibited a significantly increased survival rate, reduced skin lesion size, and reduced systemic GAS dissemination in comparison to the wild type strain...
2018: Frontiers in Microbiology
Milton Fabian Suárez-Ortegón, Eduardo Ensaldo-Carrasco, Ting Shi, Stela McLachlan, José Manuel Fernández-Real, Sarah H Wild
BACKGROUND AND AIMS: Mechanisms for the association between iron stores and risk factors for diabetes and cardiovascular disease, such as metabolic syndrome (MetS) and its components, are still not clear. We evaluated the associations between ferritin levels, MetS and its individual components, and potential role of confounding, in a meta-analysis. METHODS: We searched articles in MEDLINE and EMBASE until February 14th, 2018. There were two approaches: meta-analysis of 1) cross-sectional and longitudinal studies and 2) only cross-sectional studies...
May 23, 2018: Atherosclerosis
Tasila Mwale, Mohammad Mahmudur Rahman, Debapriya Mondal
Use of excess water in cooking of rice is a well-studied short-term arsenic removal technique. However, the outcome on the nutritional content of rice is not well addressed. We determined the benefit of different cooking techniques on arsenic removal and the associated risk of losing the essential elements in rice. Overall, we found 4.5%, 30%, and 44% decrease in the arsenic content of rice when cooked with rice-to-water ratios of 1:3, 1:6 ( p = 0.004), and 1:10 (parboiling; p < 0.0001), respectively. All the essential elements (except iron, selenium, and copper) incurred a significant loss when rice was cooked using the 1:6 technique: potassium (50%), nickel (44...
May 23, 2018: International Journal of Environmental Research and Public Health
Jacqueline M Chaparro, David G Holm, Corey D Broeckling, Jessica E Prenni, Adam L Heuberger
Potato ( Solanum tuberosum L.) is an important global food crop that contains phytochemicals with demonstrated effects on human health. Understanding sources of chemical variation of potato tuber can inform breeding for improved health attributes of the cooked food. Here, a comprehensive metabolomics (UPLC- and GC-MS) and ionomics (ICP-MS) analysis of raw and cooked potato tuber was performed on 60 unique potato genotypes that span 5 market classes including russet, red, yellow, chip, and specialty potatoes...
2018: Frontiers in Nutrition
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