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Dyslipidaemias

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https://www.readbyqxmd.com/read/29241322/modulatory-effects-of-dietary-supplementation-by-vernonia-amygdalina-on-high-fat-diet-induced-obesity-in-wistar-rats
#1
Chima A Ekeleme-Egedigwe, Ifeoma I Ijeh, Polycarp N Okafor
BACKGROUND: Obesity is a growing public health problem arising from energy imbalance. The effect of 10% dietary incorporation of Vernonia amygdalina (VA) leaves into high-fat diets on some biological markers of adiposity and dyslipidaemia was investigated. METHODS: Experimental diets consisted of the following – CD (control diet); HFD (high-fat diet); and HFD- VA (HFD containing 10% Vernonia amygdalina leaves) supplementation. Fifteen male Wistar rats were randomly divided into three groups of five animals each...
October 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/29240062/-carotid-revascularization-in-type-2-diabetes-mellitus-significance-of-chronic-hyperglycaemia
#2
M M Tanashian, S I Skrylev, K V Antonova, R B Medvedev
Patients with type 2 diabetes mellitus (type 2 DM) are typically prone to the development of cerebral atherosclerosis. Presented herein are the results of examination of patients suffering from ischaemic cerebrovascular diseases on the background of type 2 DM subjected to open surgical or endovascular interventions. In patients with cerebrovascular pathology and type 2 DM, atherosclerosis progresses on the background of chronic hyperglycaemia combined with dyslipidaemia, leading to increased incidence of the development of cerebral circulatory impairments and detection of the indications for carrying out angioreconstructive operations on the internal carotid arteries...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29234164/dyslipidaemia-in-nephrotic-syndrome-mechanisms-and-treatment
#3
Shipra Agrawal, Joshua J Zaritsky, Alessia Fornoni, William E Smoyer
This corrects the article DOI: 10.1038/nrneph.2017.155.
December 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29234057/effect-of-carnosine-supplementation-on-the-plasma-lipidome-in-overweight-and-obese-adults-a-pilot-randomised-controlled-trial
#4
Estifanos Baye, Jozef Ukropec, Maximilian Pj de Courten, Silvia Vallova, Patrik Krumpolec, Timea Kurdiova, Giancarlo Aldini, Barbara Ukropcova, Barbora de Courten
Carnosine has been shown to reduce oxidation and glycation of low density lipoprotein hence improving dyslipidaemia in rodents. The effect of carnosine on human plasma lipidome has thus far not been investigated. We aimed to determine whether carnosine supplementation improves the plasma lipidome in overweight and obese individuals. Lipid analysis was performed by liquid chromatography mass spectrometry in 24 overweight and obese adults: 13 were randomly assigned to 2 g carnosine daily and 11 to placebo, and treated for 12 weeks...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228975/prediabetes-and-cardiovascular-complications-study-paccs-international-collaboration-4%C3%A2-years-summary-and-future-direction
#5
E U Nwose, R S Richards, P T Bwititi, E O Igumbor, E J Oshionwu, K Okolie, I C Onyia, A Pokhrel, P Gyawali, J N Okuzor, V M Oguoma, F W Gardiner, L Wang
OBJECTIVE: The prediabetes and cardiovascular complications studies proposes to develop a screening protocol for diabetes cardiovascular risk, and strategies for holistic management amongst others. Over 500 participants were recruited in the first 2 years of rural community research screening. Specific for this report, various published findings were reviewed. The objective is to summarize research outcomes and itemize limitations as they constitute basis of future directions. RESULTS: Affordability and availability are major confounding behavioural change wheel factors in the rural community...
December 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29225514/elevation-of-small-dense-low-density-lipoprotein-cholesterol-a-possible-antecedent-of-atherogenic-lipoprotein-phenotype-in-type-2-diabetes-patients-in-jos-north-central-nigeria
#6
Kenneth O Inaku, Obasola O Ogunkeye, Fayeofori M Abbiyesuku, Evelyn K Chuhwak, Christian O Isichei, Lucius C Imoh, Noel O Amadu, Alexander O Abu
Background: The global prevalence of type 2 diabetes is increasing. Dyslipidaemia is a known complication of diabetes mellitus manifesting frequently as cardiovascular diseases and stoke. Elevation of small, dense low density lipoprotein has been recognised as a component of the atherogenic lipoprotein phenotype associated with cardiovascular complications. We speculate that the elevation of this lipoprotein particle may be the antecedent of the atherogenic lipoprotein phenotype. This study therefore aims to determine the pattern of dyslipidaemia among diabetes mellitus patients in Jos, North-Central Nigeria...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29225000/-validity-of-the-abdominal-ecography-in-primary-care-for-detection-of-aorta-abdominal-aneurism-in-male-between-65-and-75-years
#7
Laura Bravo-Merino, Noelia González-Lozano, Ruth Maroto-Salmón, Gloria Meijide-Santos, Patricio Suárez-Gil, Ana Fañanás-Mastral
OBJECTIVE: To determine the usefulness of ultrasound examination in Primary Care (PC) for the detection of abdominal aortic aneurysm (AAA) in male patients from 65-75 years old, as well as the consistency between observers on the diagnosis between general practitioners and the reference specialty in this area, Vascular Surgery. To estimate the prevalence of AAA in that population and its association with risk factors. DESIGN: Cross-sectional descriptive study. LOCATION: Healthcare Centres of Coto and Calzada II (Gijón, Spain)...
December 7, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29221483/the-role-of-sleepiness-on-arterial-stiffness-improvement-after-cpap-therapy-in-males-with-obstructive-sleep-apnea-a-prospective-cohort-study
#8
Maria Alexandra Mineiro, Pedro Marques da Silva, Marta Alves, Ana Luísa Papoila, Maria João Marques Gomes, João Cardoso
BACKGROUND: Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk. This study aim to assess differences in changes in arterial stiffness of two groups of patients, defined as having daytime sleepiness or not, after continuous positive airway pressure (CPAP) treatment. METHODS: A selected cohort of consecutive male patients, under 65 years old, with moderate to severe OSA and without great number of comorbidities was studied. The diagnosis was confirmed by home respiratory poligraphy...
December 8, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29220052/hypoglycemic-and-hypolipidemic-effects-of-anthocyanins-extract-from-black-soybean-seed-coat-in-high-fat-diet-and-streptozotocin-induced-diabetic-mice
#9
Zhongqin Chen, Cong Wang, Yuxiang Pan, Xudong Gao, Haixia Chen
Black soybean seed coat extract (BSSCE) is a rich source of anthocyanins with multiple health effects. This study was aimed at investigating the composition and hypoglycemic and hypolipidemic effects of BSSCE in vitro and in a high-fat diet and streptozotocin (STZ)-induced diabetic mice. The anthocyanins of BSSCE were identified as cyanidin-3-O-glucoside, delphinidin-3-O-glucoside, and peonidin-3-O-glucoside by HPLC-MS. Results demonstrated that BSSCE exhibited strong inhibitory activities for α-amylase, potent inhibition activity against lipid accumulation in HepG2 cells and protection effect on H2O2-induced oxidative stress-damaged HepG2 cells...
December 8, 2017: Food & Function
https://www.readbyqxmd.com/read/29217719/can-traditional-risk-factors-explain-the-higher-risk-of-cardiovascular-disease-in-south-asians-compared-to-europeans-in-norway-and-new-zealand-two-cohort-studies
#10
Kjersti S Rabanal, Haakon E Meyer, Grethe S Tell, Jannicke Igland, Romana Pylypchuk, Suneela Mehta, Bernadette Kumar, Anne Karen Jenum, Randi M Selmer, Rod Jackson
OBJECTIVES: The objective was to prospectively examine potential differences in the risk of first cardiovascular disease (CVD) events between South Asians and Europeans living in Norway and New Zealand, and to investigate whether traditional risk factors could explain any differences. METHODS: We included participants (30-74 years) without prior CVD in a Norwegian (n=16 606) and a New Zealand (n=129 449) cohort. Ethnicity and cardiovascular risk factor information was linked with hospital registry data and cause of death registries to identify subsequent CVD events...
December 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/29216336/managing-diabetic-kidney-disease
#11
Sagen Zac-Varghese, Peter Winocour
Introduction: Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD). This review covers the pillars of care essential for the management of diabetic kidney disease (DKD) including (1) early diagnosis, (2) improved glycaemic control, (3) treatment of hypertension, (4) identification and treatment of associated metabolic bone disease and (5) identification and effective management of dyslipidaemia and additional cardiovascular risk factors. Sources of data: We searched PubMed for articles using search terms: diabetic nephropathy, diabetic kidney disease, diabetes and chronic kidney disease...
December 5, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29207752/study-of-left-ventricular-mass-and-its-determinants-on-echocardiography
#12
Namrata Guleri, Susheela Rana, Randhir S Chauhan, Prakash Chand Negi, Yogesh Diwan, Deepa Diwan
Introduction: Increased Left Ventricular Mass (LVM) is an independent risk factor for cardiovascular morbidity and mortality. Aim: This study was done to find the prevalence and determinants of LVM in the Northern Indian population. Materials and Methods: A prospective cross-sectional observational study was carried out in a tertiary care centre in Himachal Pradesh, India and the study population included all consecutive patients fulfilling the inclusion criteria attending cardiology OPD on seeking medical attention with various symptoms for dyslipidaemia, hypertension but not on medication over a period of one year...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29203808/association-between-smoking-and-the-peripheral-vestibular-disorder-a-retrospective-cohort-study
#13
Masaoki Wada, Taro Takeshima, Yosikazu Nakamura, Shoichiro Nagasaka, Toyomi Kamesaki, Eiji Kajii, Kazuhiko Kotani
Common inner ear diseases include peripheral vestibular disorder (PVD) and hearing impairment. The association between smoking and peripheral vestibular disorder (PVD) is unclear. We examined associations between smoking and new PVD events. In this retrospective study, we consecutively enrolled 393 participants aged ≥20 years [mean age 65.3 years; males 133 (33.8%)] treated for hypertension, dyslipidaemia, or diabetes mellitus at a primary care clinic between November 2011 and March 2013. Participants were categorized as ever-smokers (including current and past -smokers; divided per <30 and ≥30 pack-years), and never-smokers...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29200680/poor-risk-advanced-renal-cell-carcinoma-outcomes-from-a-registry-in-a-tertiary-cancer-center
#14
Anant Ramaswamy, Amit Joshi, Vanita Noronha, Vijay Patil, Arvind Sahu, Deepan R Manickam, Rushabh Kothari, Nilesh Sable, Archi Agrawal, Santosh Menon, Kumar Prabhash
Background: Poor-risk advanced Renal cell carcinoma (RCC) are an under-evaluated and difficult to treat subset of patients with poor prognosis. While Temsirolimus is the approved first line therapy for this category, Tyrosine kinase inhibitors (TKIs) are also commonly uses as initial treatment. We present an analysis of poor-risk advanced RCC treated in our institute. Materials and Methods: Patients diagnosed as poor-risk (as per Heng criteria) advanced RCC from June 2008 to December 2015 were analysed for baseline demographics, treatment received, toxicity (primarily Grade 3 and Grade 4), response rates (RR) and survival...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29199027/10-patients-10-years-long-term-follow-up-of-cardiovascular-risk-factors-in-glut1-deficiency-treated-with-ketogenic-diet-therapies-a%C3%A2-prospective-multicenter-case-series
#15
Nicole Heussinger, Adela Della Marina, Andreas Beyerlein, Baerbel Leiendecker, Sofia Hermann-Alves, Robert Dalla Pozza, Joerg Klepper
BACKGROUND AND AIMS: Glut1 Deficiency (Glut1D) is caused by impaired glucose transport into brain. The resulting epileptic encephalopathy and movement disorders can be treated effectively by high-fat carbohydrate-restricted ketogenic diet therapies (KDT) mimicking fasting and providing ketones as an alternative cerebral fuel. Recently 6-24 months follow-ups of epileptic patients reported elevated blood lipids and intima thickening of the carotid artery raising concerns about potential cardiovascular risks by KDT...
November 11, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29197883/clinical-characteristics-treatment-and-2-year-outcomes-in-malaysian-and-bruneian-patients-with-stable-coronary-artery-within-the-worldwide-clarify-registry
#16
K H Chee, G H Choo, A N B Jamaluddin, K Mahendran, N Greenlaw, A Chandran
INTRODUCTION: The on-going, international, prospective, observational, longitudinal CLARIFY registry is investigating the demographics, clinical profiles, management and outcomes of patients with stable coronary artery disease (CAD). This paper assesses baseline characteristics, treatment, and clinical outcomes at two years' follow-up of Malaysian/Bruneian patients compared with the overall registry population. METHOD: Between November 2009 and July 2010, outpatients from 45 countries who met the criteria for stable CAD were recruited into the registry...
October 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29194462/new-strategies-for-the-development-of-lipid-lowering-therapies-to-reduce-cardiovascular-risk
#17
Ian Graham, Chuck Shear, Pieter De Graeff, Caroline Boulton, Alberico L Catapano, Wendy Gattis Stough, Stefan C Carlsson, Guy De Backer, Joseph Emmerich, Scott Greenfeder, Albert M Kim, Dominik Lautsch, Tu Nguyen, Steven E Nissen, Krishna Prasad, Kausik Ray, Jennifer G Robinson, William J Sasiela, Karsten Bruins Slot, Erik Stroes, Tom Thuren, Bart Van der Schueren, Maja Velkovski-Rouyer, Scott M Wasserman, Olov Wiklund, Emmanouil Zouridakis
The very high occurrence of cardiovascular events presents a major public health issue because treatment remains suboptimal. Lowering low-density lipoprotein cholesterol (LDL-C) with statins or ezetimibe in combination with a statin reduces major adverse cardiovascular events. The cardiovascular risk reduction in relation to the absolute LDL-C reduction is linear for most interventions without evidence of attenuation or increase in risk at low LDL-C levels. Opportunities for innovation in dyslipidaemia treatment should address the substantial risk of lipid-associated cardiovascular events among patients optimally treated per guidelines but who cannot achieve LDL-C goals, could benefit from additional LDL-C lowering therapy, or experience side effects of statins...
November 28, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29192955/epidemiology-of-dyslipidemia-in-professional-drivers-results-of-racer-abpm-risk-of-adverse-cardiovascular-events-among-professional-drivers-in-poland-ambulatory-blood-pressure-monitoring-study
#18
Bartosz Krzowski, Anna E Płatek, Filip M Szymanski, Anna Ryś, Karolina Semczuk-Kaczmarek, Karolina Adamkiewicz, Marcin Kotkowski, Krzysztof J Filipiak
BACKGROUND: Professional drivers are a group exposed to many cardiovascular risk factors. Non-systematic working hours, prolonged stress, low physical activity, along with irregular, in most cases, unhealthy meals are common aspects of the normal working schedule of most of the professional drivers. These translate into high risk of cardiovascular disease. AIM: The aim of the current analysis was to establish the prevalence of dyslipidaemia in a group of continuous professional drivers...
December 1, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29191193/adequacy-of-control-of-cardiovascular-risk-factors-in-ambulatory-patients-with-type-2-diabetes-attending-diabetes-out-patients-clinic-at-a-county-hospital-kenya
#19
Mercy W Kimando, Frederick C F Otieno, Elijah N Ogola, Kenn Mutai
BACKGROUND: Type 2 diabetes is associated with substantial cardiovascular morbidity and mortality arising from the high prevalence of cardiovascular risk factors such as hypertension, dyslipidaemia, obesity, poor glycaemic control and albuminuria. Adequacy of control of these risk factors determines the frequency and outcome of cardiovascular events in the patients. Current clinical practice guidelines emphasize primary prevention of cardiovascular disease in type 2 diabetes. There is scarce data from the developing countries, Kenya included, on clinical care of patients with type 2 diabetes in the regions that are far away from tertiary health facilities...
December 1, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29190746/hepatic-aryl-hydrocarbon-receptor-nuclear-translocator-arnt-regulates-metabolism-in-mice
#20
Christopher H Scott, Kuan-Minn Cha, Jason Ngai, Changtao Jiang, Kim Cheng, Rebecca A Stokes, Kenneth W K Ho, Jacob George, Frank J Gonzalez, Jenny E Gunton
BACKGROUND & AIMS: Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) and its partners hypoxia-inducible factors (HIF)-1α and HIF-2α are candidate factors for the well-known link between the liver, metabolic dysfunction and elevation in circulating lipids and glucose. Methods: Hepatocyte-specific ARNT-null (LARNT), HIF-1α-null (LHIF1α) and HIF-2α-null (LHIF2α) mice were created. RESULTS: LARNT mice had increased fasting glucose, impaired glucose tolerance, increased glucose production, raised post-prandial serum triglycerides (TG) and markedly lower hepatic ATP versus littermate controls...
2017: PloS One
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