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Dyslipidaemias

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https://www.readbyqxmd.com/read/29457826/prevalence-of-cardiometabolic-risk-factors-among-professional-male-long-distance-bus-drivers-in-lagos-south-west-nigeria-a-cross-sectional-study
#1
Casmir E Amadi, Tim P Grove, Amam C Mbakwem, Obianuju B Ozoh, Oyewole A Kushimo, David A Wood, Michael Akinkunmi
BACKGROUND: Professional drivers are known to be at high risk of cardiovascular disease (CVD). This study was carried out to highlight these risk factors and their predictors among male long-distance professional bus drivers in Lagos, south-west Nigeria, with a view to improving health awareness in this group. METHOD: Socio-demographic data, anthropometric indices, blood pressure, fasting plasma blood glucose levels and lipid and physical activity profiles of 293 drivers were measured...
February 19, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29453473/prehospital-events-in-st-elevation-myocardial-infarction-undergoing-primary-angioplasty
#2
Sachin Dhungel, Rabi Malla, Chandramani Adhikari, Arun Maskey, Rajeeb Rajbhandari, Ranjit Sharma, Deewakar Sharma, Man Bhadhur Kc, Ajay Adhikari, Binaya Rauniyar, Dipak Limbu, Milan Gautam
INTRODUCTION: Pre-hospital delay includes time from onset of symptoms of myocardial infarction till arrival to emergency room of the hospital. This defines time from symptom onset to first medical contact and first medical contact to emergency room. This study aims to study the prehospital events and determining factors in patients undergoing primary angioplasty. METHODS: This was a cross sectional study in Shahid Gangalal National Heart Centre for three months...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29452989/prognostic-role-of-cardiac-calcifications-in-primary-prevention-a-powerful-marker-of-adverse-outcome-highly-dependent-on-underlying-cardiac-rhythm
#3
Carmine Mazzone, Gianni Cioffi, Concetta Di Nora, Giulia Barbati, Federica Guidetti, Pompilio Faggiano, Nicola Gaibazzi, Giorgio Faganello, Endria Casanova Borca, Andrea Di Lenarda
BACKGROUND: Increasing evidence exists regarding calcium detected in aortic cusps and/or mitral annulus (AOC_MAC) at transthoracic echocardiogram as a predictor of cardiovascular (CV) events and mortality. PURPOSE: To verify whether AOC_MAC has a prognostic role in the setting of primary prevention independently of the presence of atrial fibrillation (AF). METHODS: All subjects consecutively referred from January 2011 to October 2014 to the Cardiovascular Centre for CV risk assessment in primary prevention were selected...
January 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29452601/reactive-hyperemia-index-rhi-and-cognitive-performance-indexes-are-associated-with-histologic-markers-of-liver-disease-in-subjects-with-non-alcoholic-fatty-liver-disease-nafld-a-case-control-study
#4
Antonino Tuttolomondo, Salvatore Petta, Alessandra Casuccio, Carlo Maida, Vittoriano Della Corte, Mario Daidone, Domenico Di Raimondo, Rosaria Pecoraro, Roberto Fonte, Anna Cirrincione, Rita Zafonte, Daniela Cabibi, Calogero Cammà, Vito Di Marco, Anna Licata, Franco Magliozzo, Giulio Marchesini, Giovanni Merlino, Antonio Craxì, Antonio Pinto
BACKGROUND: No study evaluated vascular health markers in subjects with non-alcoholic fatty liver disease (NAFLD) through a combined analysis of reactive hyperemia peripheral arterial tonometry (RH-PAT) and arterial stiffness indexes. AIM OF THE STUDY: We aimed to assess whether NAFLD and its histological severity are associated with impairment of arterial stiffness and RH-PAT indexes in a mixed cohort of patients with biopsy-proven NAFLD. MATERIALS AND METHODS: The Kleiner classification was used to grade NAFLD grade...
February 16, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29448285/-risk-factors-and-therapeutic-goals-for-primary-and-secondary-cardiovascular-prevention-significance-for-the-glaucoma-patient
#5
Claudia Hacke, Carl Erb, Burkhard Weisser
Hypertension, diabetes mellitus and dyslipidaemia are among the most important cardiovascular risk factors. In addition, there is an association with the development and progression of glaucoma. During the last years, there has been an intense discussion concerning optimal treatment goals for these risk factors. Recently, the American Heart Association has defined a blood pressure greater than 130/80 mmHg as hypertension and the European guidelines will follow this definition. These lower blood pressure limits increase the risk for a too strict blood pressure treatment with night values, which might be too low for glaucoma patients...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29441984/direct-oral-anticoagulants-in-real-clinical-practice-analysis-of-patient-characteristics-and-prescribing-patterns-in-a-large-teaching-hospital
#6
B Kováčová, J Červeňová
Direct oral anticoagulants (DOACs) became rapidly accepted as an alternative to warfarin in the prevention of stroke in atrial fibrillation and prophylaxis of thromboembolic events. Their safety and efficacy have been well documented in several studies, however, as with any new drug, use in real-world population often reveals risk factors that may affect treatment outcomes. The aim of the study was to determine the prescribing patterns and analyse patient characteristics to identify incidence of selected factors (age, weight, comorbidities and interacting medication) that may affect DOAC safety and efficacy...
September 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29437994/metabolic-profiling-of-visceral-adipose-tissue-from-obese-subjects-with-or-without-metabolic-syndrome
#7
Eleonora Candi, Manfredi Tesauro, Carmine Cardillo, Anna Maria Lena, Francesca Schinzari, Giuseppe Rodia, Giuseppe Sica, Paolo Gentileschi, Valentina Rovella, Margherita Annicchiarico-Petruzzelli, Nicola Di Daniele, Gerry Melino
Obesity represents one of the most complex public health challenges and has recently reached epidemic proportions.  Obesity is also considered to be primarily responsible for the rising prevalence of metabolic syndrome, defined as the coexistence in the same individual of several risk factors for atherosclerosis, including dyslipidaemia, hypertension and hyperglycaemia, as well as for cancer. Additionally, the presence of three of the five risk factors (abdominal obesity, low HDL cholesterol, high triglycerides, high fasting glucose and high blood pressure) characterizes metabolic syndrome, which has serious clinical consequences...
February 8, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29437865/associations-of-dyslipidaemia-and-lipid-lowering-treatment-with-risk-of-postoperative-cognitive-dysfunction-a-systematic-review-and-meta-analysis
#8
REVIEW
Insa Feinkohl, Georg Winterer, Tobias Pischon
BACKGROUND: Lipid imbalance is linked to age-related cognitive impairment, but its role in postoperative cognitive dysfunction (POCD) is unknown. Here, we present a systematic review and meta-analysis on dyslipidaemia, lipid-lowering treatment and POCD risk. METHODS: PubMed, Ovid SP and Cochrane databases were searched for longitudinal studies that reported on associations of any measure of dyslipidaemia and/or lipid-lowering treatment with POCD as relative risks (RRs) or ORs...
February 2, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29437709/prader-willi-syndrome-a-nest-for-premature-coronary-artery-disease
#9
Diogo Rodrigues Brás, Pedro Semedo, Bruno Cordeiro Piçarra, Renato Fernandes
Individuals affected by Prader-Willi syndrome (PWS) may show increased risk for coronary artery disease (CAD), which probably relates, at least, with high burden of cardiovascular risk factors.A 27-year-old man with PWS, obesity, hypertension, diabetes mellitus and dyslipidaemia attended the emergency department with complaints of flu-like condition and chest pain. The ECG revealed a mild ST-segment elevation in inferior leads, followed by positive myocardial necrosis biomarkers. Attending to the high cardiovascular risk profile, ST-segment elevation in inferior territory and wall motion abnormalities, a coronary angiogram was performed...
February 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29436756/alirocumab-versus-usual-lipid-lowering-care-as-add-on-to-statin-therapy-in-individuals-with-type-2-diabetes-and-mixed-dyslipidaemia-the-odyssey-dm-dyslipidemia-randomized-trial
#10
Kausik K Ray, Lawrence A Leiter, Dirk Müller-Wieland, Bertrand Cariou, Helen M Colhoun, Robert R Henry, Francisco J Tinahones, Maja Bujas-Bobanovic, Catherine Domenger, Alexia Letierce, Rita Samuel, Stefano Del Prato
AIMS: Individuals with type 2 diabetes (T2DM) and mixed dyslipidaemia represent a high-risk and difficult-to-treat population. ODYSSEY DM-DYSLIPIDEMIA (NCT02642159) compared alirocumab, a proprotein convertase subtilisin-kexin type 9 inhibitor, with usual care (UC) in individuals with T2DM and mixed dyslipidaemia not optimally managed by maximally-tolerated statins. MATERIALS AND METHODS: UC options (no additional lipid-lowering therapy; fenofibrate; ezetimibe; omega-3 fatty acid; nicotinic acid) were selected prior to stratified randomization to open-label alirocumab 75 mg every 2 weeks (Q2W; with increase to 150 mg Q2W at Week [W]12 if W8 non-high-density lipoprotein cholesterol [non-HDL-C] was ≥2...
February 13, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29430576/prevalence-and-correlates-of-diabetes-mellitus-and-dyslipidaemia-in-a-long-stay-inpatient-schizophrenia-population-in-singapore
#11
Saleha Shafie, Siau Pheng Lee, Samantha Bee Cheng Ong, Peizhi Wang, Esmond Seow, Hui Lin Ong, Siow Ann Chong, Mythily Subramaniam
INTRODUCTION: Patients with schizophrenia have shorter life expectancy and one of the main causes of death is cardiovascular disease (CVD). Modifiable risk factors for CVD include diabetes mellitus (DM) and dyslipidaemia. This study aimed to establish: (a) the prevalence and correlates of DM and dyslipidaemia; (b) the proportion of those whose condition was well controlled; and (c) the incidence of undiagnosed DM and dyslipidaemia in a long-stay inpatient schizophrenia population. METHODS: Data was collected to assess the physical health status of 110 inpatients with schizophrenia who had been in hospital for over one year...
February 12, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29425253/the-kca3-1-blocker-tram34-reverses-renal-damage-in-a-mouse-model-of-established-diabetic-nephropathy
#12
Chunling Huang, Ling Zhang, Ying Shi, Hao Yi, Yongli Zhao, Jason Chen, Carol A Pollock, Xin-Ming Chen
Despite optimal control of hyperglycaemia, hypertension, and dyslipidaemia, the number of patients with diabetic nephropathy (DN) continues to grow. Strategies to target various signaling pathways to prevent DN have been intensively investigated in animal models and many have been proved to be promising. However, targeting these pathways once kidney disease is established, remain unsatisfactory. The clinical scenario is that patients with diabetes mellitus often present with established kidney damage and need effective treatments to repair and reverse the kidney damage...
2018: PloS One
https://www.readbyqxmd.com/read/29420594/effects-of-metabolic-syndrome-on-bone-mineral-density-histomorphometry-and-remodelling-markers-in-male-rats
#13
Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana
This study aimed to evaluate the effects of metabolic syndrome (MetS) induced by high-carbohydrate high-fat (HCHF) diet on bone mineral density (BMD), histomorphometry and remodelling markers in male rats. Twelve male Wistar rats aged 12 weeks old were randomized into two groups. The normal group was given standard rat chow while the HCHF group was given HCHF diet to induce MetS. Abdominal circumference, blood glucose, blood pressure, and lipid profile were measured for the confirmation of MetS. Bone mineral density, histomorphometry and remodelling markers were evaluated for the confirmation of bone loss...
2018: PloS One
https://www.readbyqxmd.com/read/29419522/gender-differences-in-mortality-among-st-elevation-myocardial-infarction-patients-in-malaysia-from-2006-to-2013
#14
Nurliyana Juhan, Yong Z Zubairi, A S Zuhdi, Zarina Mohd Khalid, Wan Azman Wan
BACKGROUND: Coronary artery disease (CAD) is one of the leading causes of death in Malaysia. However, the prevalence of CAD in males is higher than in females and mortality rates are also different between the two genders. This suggest that risk factors associated with mortality between males and females are different, so we compared the clinical characteristics and outcome between male and female STEMI patients. OBJECTIVES: To identify the risk factors associated with mortality for each gender and compare differences, if any, among ST-elevation myocardial infarction (STEMI) patients...
January 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29412116/prevention-of-vascular-complications-in-diabetes-mellitus-patients-focus-on-the-arterial-wall
#15
Mojca Lunder, Miodrag Janic, Miso Sabovic
In diabetes mellitus (DM), hyperglycaemia and insulin resistance progressively lead to both microvascular and macrovascular complications. Whereas the incidence of microvascular complications is closely related to tight glycaemic control, this does not apply to macrovascular complications. Hyperglycaemia influences many interweaving molecular pathways that initially lead to increased oxidative stress, increased inflammation and endothelial dysfunction. The latter represents the initial in both types of vascular complications; it represents the "obligatory damage" in microvascular complications development and only "introductory damage" in macrovascular complications development...
February 5, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29412113/screening-for-rare-genetic-variants-associated-with-atherosclerosis-opportunity-for-personalized-medicine
#16
Ana Peterlin, Danijel Petrovic, Borut Peterlin
Atherosclerosis and its clinical manifestations is a leading cause of disease burden worldwide. Currently, most of the individuals carrying a strong predisposition to complications of atherosclerosis because of monogenic dyslipidaemias remain undiagnosed and consequently are not given an opportunity for prevention. Therefore, one of the main public health challenges remains the identification of individuals with significantly increased risk for atherosclerosis due to monogenic predisposition. Next-generation sequencing (NGS) has revolutionized genetic testing in symptomatic patients...
February 5, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29412075/pcsk9-inhibition-for-ldl-lowering-and-beyond-implications-for-patients-with-peripheral-artery-disease
#17
Katrin Gebauer, Holger Reinecke
Low-density lipoprotein cholesterol (LDL-C) has been proven to be a causal factor of atherosclerosis and, along with other triggers like inflammation, the most frequent reason for peripheral arterial disease. Moreover, a linear correlation between LDL-C concentration and cardiovascular outcome in high-risk patients could be established during the past century. After the development of statins, numerous randomized trials have shown the superiority for LDL-C reduction and hence the decrease in cardiovascular outcomes including mortality...
February 7, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29411495/efficacy-of-a-telephone-based-medical-nutrition-program-on-blood-lipid-and-lipoprotein-metabolism-results-of-our-healthy-heart
#18
Kelsey E Miller, Daniel C Martz, Cathey Stoner, Audrey Jowers, Megan L Taheri, Mark A Sarzynski, Rachel A H Davis, Eric P Plaisance
AIM: Derangements in blood lipid and lipoprotein metabolism are one of the leading causes of coronary heart disease (CHD). Therapeutic lifestyle changes such as diet and exercise are often prescribed to improve blood lipid and lipoprotein characteristics, but the efficacy of a telephone-based health coaching program has not been thoroughly explored. Our purpose was to examine effects of the Our Healthy Heart (OHH) Program on blood lipid and lipoprotein characteristics of individuals with mixed dyslipidaemia...
February 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29405543/legacy-benefits-of-blood-glucose-blood-pressure-and-lipid-control-in-people-with-diabetes-and-cardiovascular-disease-time-to-overcome-multifactorial-therapeutic-inertia
#19
REVIEW
Kamlesh Khunti, Mikhail Kosiborod, Kausik K Ray
Cardiovascular disease is a major cause of morbidity and mortality, in particular in people with diabetes and is also the largest contributor to healthcare costs in this population (1) . However, good quality randomised controlled trials and systematic reviews have shown that management of risk factors such as blood pressure, dyslipidaemia and glucose can lead to improved microvascular and macrovascular complications in people with type 2 diabetes mellitus (T2DM). Legacy effect or metabolic memory has been a phenomenon used to describe the prolonged benefits of glucose, blood pressure or lipid control in people with cardiovascular disease, diabetes or in primary prevention of cardiovascular disease by early risk factor control...
February 6, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29402233/a-population-based-screening-study-for-cardiovascular-diseases-and-diabetes-in-danish-postmenopausal-women-acceptability-and-prevalence
#20
Marie Dahl, Lars Frost, Rikke Søgaard, Ib Christian Klausen, Vibeke Lorentzen, Jes Lindholt
BACKGROUND: Reducing women's cardiovascular risk and the economic costs associated with cardiovascular diseases (CVD) and diabetes (DM) continues to be a challenge. Whether a multifaceted CVD screening programme is beneficial as a preventive strategy in women remains uncertain. The aim of this study was to investigate the prevalence of CVD and DM as well as the acceptability toward screening and preventive actions. METHODS: An observational study was performed among all women born in 1936, 1941, 1946 and 1951 living in Viborg Municipality, Denmark, from October 2011...
February 5, 2018: BMC Cardiovascular Disorders
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