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Dyslipidaemias

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https://www.readbyqxmd.com/read/28526014/the-use-of-lipid-lowering-therapy-and-effects-of-antihyperglycaemic-therapy-on-lipids-in-subjects-with-type-2-diabetes-with-or-without-cardiovascular-disease-a-pooled-analysis-of-data-from-eleven-randomized-trials-with-insulin-glargine-100%C3%A2-u-ml
#1
Markolf Hanefeld, Louise Traylor, Ling Gao, Wolfgang Landgraf
BACKGROUND: Dyslipidaemia is a major contributor to the increased risk of cardiovascular disease (CVD) associated with type 2 diabetes (T2D). This study aimed to characterize the extent of lipid-lowering therapy use and its impact on lipid and glycaemic outcomes in people with T2D uncontrolled on oral agents who were enrolled in insulin glargine 100 units/mL (Gla-100) randomized controlled trials (RCTs). METHODS: A post hoc patient-level pooled analysis of eleven RCTs (≥24 weeks' duration) comparing Gla-100 (±oral antidiabetes drugs [OADs]) with OADs alone in people with T2D was performed...
May 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28523635/2017-position-paper-of-the-italian-society-for-cardiovascular-prevention-siprec-for-an-updated-clinical-management-of-hypercholesterolemia-and-cardiovascular-risk-executive-document
#2
Massimo Volpe, Roberto Volpe, Giovanna Gallo, Vivianne Presta, Giuliano Tocci, Emanuela Folco, Andrea Peracino, Elena Tremoli, Bruno Trimarco
The benefits achieved by implementing cardiovascular prevention strategies in terms of reduced incidence of atherosclerotic diseases and mortality are accepted, worldwide. In particular, the clinical management of hypercholesterolemia has a fundamental role for all preventive strategies, both in primary and secondary prevention, at each stage of cardiovascular risk. Since the net clinical benefit of lipid-lowering therapy largely depends on baseline individual cardiovascular risk profile, the assessment of individual risk is essential to establish type and intensity of both preventive and therapeutic strategies...
May 18, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28518175/dyslipidaemia-hdl-related-biomarkers-of-cardiovascular-risk
#3
Gregory B Lim
No abstract text is available yet for this article.
May 18, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28511733/similarities-and-interactions-between-the-ageing-process-and-high-chronic-intake-of-added-sugars
#4
Eva Gatineau, Sergio Polakof, Dominique Dardevet, Laurent Mosoni
In our societies, the proportions of elderly people and of obese individuals are increasing. Both factors are associated with high health-related costs. During obesity, many authors suggest that it is a high chronic intake of added sugars (HCIAS) that triggers the shift towards pathology. However, the majority of studies were performed in young subjects and only a few were interested in the interaction with the ageing process. Our purpose was to discuss the metabolic effects of HCIAS, compare with the effects of ageing, and evaluate how deleterious the combined action of HCIAS and ageing could be...
May 17, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28511427/role-of-omega-3-fatty-acids-on-lipid-profile-in-diabetic-dyslipidaemia-single-blind-randomised-clinical-trial
#5
Shaylika Chauhan, Hanish Kodali, Jawad Noor, Karuna Ramteke, Vidisha Gawai
INTRODUCTION: Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipimea, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular complications. Omega-3 fatty acids are fish oil derivative introduced in the market for dyslipidaemia associated with increased triglyceride level. AIM: To study the effect of omega-3 fatty acids on lipid profile in Type II diabetes patients...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509871/nutraceutical-value-of-citrus-flavanones-and-their-implications-in-cardiovascular-disease
#6
REVIEW
Lara Testai, Vincenzo Calderone
Background- Cardiovascular diseases, including myocardial infarction, dyslipidaemia and coronary artery pathology, are a major cause of illness and death in Western countries. Therefore, identifying effective therapeutic approaches and their cellular signalling pathways is a challenging goal for medicine. In this regard, several epidemiological studies demonstrate a relationship between the intake of flavonoid-rich foods and the reduction of cardiovascular risk factors and mortality. In particular, flavonoids present in citrus fruits, such as oranges, bergamots, lemons and grapefruit (95% from flavanones), are emerging for their considerable nutraceutical value...
May 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28509399/association-of-renin-angiotensin-antagonists-with-adverse-perioperative-events-in-patients-undergoing-elective-orthopaedic-surgery-a-case-control-study
#7
Amith Zainudheen, Ian A Scott, Xenia Caney
BACKGROUND: Renin angiotensin antagonists (RAAs) may block protective vasopressor responses during surgery. Evidence linking RAAs with intraoperative hypotension and perioperative adverse events is conflicting. METHODS: Retrospective case-control study of 258 consecutive patients who underwent elective total knee or hip replacement between January 1(st) 2013 and August 31(st) 2016, and who were chronically prescribed a single blood pressure lowering agent up to the time of surgery...
May 16, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28508457/effects-of-canagliflozin-on-cardiovascular-risk-factors-in-patients-with-type-2-diabetes-mellitus
#8
REVIEW
Matthew J Budoff, John P H Wilding
BACKGROUND AND AIMS: Cardiovascular disease is the most common cause of morbidity and mortality among people with type 2 diabetes mellitus (T2DM). The main contributors to cardiovascular risk in T2DM are chronic hyperglycaemia, reduced insulin sensitivity, hypertension and dyslipidaemia. Other cardiovascular risk factors include obesity and visceral adiposity, increased arterial stiffness and renal dysfunction. Results from clinical trials, including a long-term cardiovascular outcome study, have shown that sodium glucose co-transporter 2 (SGLT2) inhibitors can provide multiple cardiometabolic benefits beyond glycaemic control including inducing mild osmotic diuresis, natriuresis and weight loss...
May 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28506456/prevalence-of-asymptomatic-coronary-heart-disease-in-the-siblings-of-young-myocardial-infarction-patients-as-detected-by-coronary-computer-tomography-angiography-a-pilot-study
#9
Nadim Shah, Chiew Wong, Nicholas Cox, Anne-Maree Kelly, Kean Soon
BACKGROUND: There is little data on the prevalence of coronary heart disease (CHD) in the young. The study aimed to estimate the prevalence of asymptomatic CHD in siblings of young patients with myocardial infarction (MI) using coronary computed tomography angiography (CCTA). METHODS: Prospective observational data was collected on siblings of patients aged ≤55 years presenting with acute MI and having coronary stenosis ≥50% on invasive coronary angiography in at least one epicardial coronary artery...
April 27, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28504110/neurological-consequences-of-obesity
#10
REVIEW
Phillipe D O'Brien, Lucy M Hinder, Brian C Callaghan, Eva L Feldman
The high prevalence of obesity is associated with an enormous medical, social, and economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by obesity contribute to the development of a wide variety of disorders and effects on the nervous system. In the CNS, mild cognitive impairment can be attributed to obesity-induced alterations in hippocampal structure and function in some patients. Likewise, compromised hypothalamic function and subsequent defects in maintaining whole-body energy balance might be early events that contribute to weight gain and obesity development...
June 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28503912/high-burden-of-metabolic-comorbidities-in-a-citywide-cohort-of-hiv-outpatients-evolving-health-care-needs-of-people-aging-with-hiv-in-washington-dc
#11
M E Levy, A E Greenberg, R Hart, L Powers Happ, C Hadigan, A Castel
OBJECTIVES: With the increasing impact of cardiovascular disease among populations aging with HIV, contemporary prevalence estimates for predisposing metabolic comorbidities will be important for guiding the provision of relevant lifestyle and pharmacological interventions. We estimated the citywide prevalence of hypertension, type 2 diabetes, dyslipidaemia, and obesity; examined differences by demographic subgroups; and assessed clinical correlates. METHODS: Utilizing an electronic medical record (EMR) database from the DC Cohort study - a multicentre prospective cohort study of HIV-infected outpatients - we assessed the period prevalence of metabolic comorbidities between 2011 and 2015 using composite definitions that incorporated diagnoses, pharmacy records, and clinical/laboratory results...
May 15, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28500248/the-association-of-the-lipidomic-profile-with-features-of-polycystic-ovary-syndrome
#12
Lisa Moran, Piyushkumar Mundra, Helena Teede, Peter J Miekle
Polycystic ovary syndrome (PCOS) affects up to 18% of reproductive-aged women with reproductive and metabolic complications. While lipidomics can identify associations between lipid species and metabolic diseases, no research has examined the association of lipid species with the pathophysiological features of PCOS. The aim of this study was to examine the lipidomic profile in women with and without PCOS. This study was a cross-sectional study in 156 age-matched pre-menopausal women (18-45 years, BMI>25 kg/m2; n=92 with PCOS, n=64 without PCOS)...
May 12, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28492287/dyslipidaemia-pcsk9-inhibitors-and-foamy-monocytes-in-familial-hypercholesterolaemia
#13
Huaizhu Wu, Christie M Ballantyne
No abstract text is available yet for this article.
May 11, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28489142/cognitive-cooperation-groups-mediated-by-computers-and-internet-present-significant-improvement-of-cognitive-status-in-older-adults-with-memory-complaints-a-controlled-prospective-study
#14
Rodrigo de Rosso Krug, Anna Quialheiro Abreu da Silva, Ione Jayce Ceola Schneider, Luiz Roberto Ramos, Eleonora d'Orsi, André Junqueira Xavier
Objective: To estimate the effect of participating in cognitive cooperation groups, mediated by computers and the internet, on the Mini-Mental State Examination (MMSE) percent variation of outpatients with memory complaints attending two memory clinics. Methods: A prospective controlled intervention study carried out from 2006 to 2013 with 293 elders. The intervention group (n = 160) attended a cognitive cooperation group (20 sessions of 1.5 hours each). The control group (n = 133) received routine medical care...
April 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28480754/low-dose-spironolactone-ameliorates-insulin-resistance-and-suppresses-elevated-plasminogen-activator-inhibitor-1-during-gestational-testosterone-exposure
#15
Lawrence A Olatunji, Taofeek O Usman, Aminat I Akinade, Oluwaseun A Adeyanju, InKyeom Kim, Ayodele O Soladoye
CONTEXT: Elevated gestational circulating testosterone has been associated with pathological pregnancies that increase the risk of development of cardiometabolic disorder in later life. OBJECTIVE: We hypothesised that gestational testosterone exposure, in late pregnancy, causes glucose deregulation and atherogenic dyslipidaemia that would be accompanied by high plasminogen activator inhibitor-1 (PAI-1). The study also hypothesise that low-dose spironolactone treatment would ameliorate these effects...
May 8, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28470176/dyslipidaemia-the-pcsk9-adventure-humanizing-extreme-ldl-lowering
#16
Michael D Shapiro, Sergio Fazio
No abstract text is available yet for this article.
June 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28469051/statins-for-prevention-of-cardiovascular-disease-in-systemic-lupus-erythematosus
#17
F A Yousef Yengej, M Limper, H L Leavis
OBJECTIVE: In systemic lupus erythematosus (SLE), cardiovascular disease (CVD) is an important cause of long-term morbidity, which could be affected by statin use. Here we review the evidence for the use of statins for the prevention of CVD in patients with SLE. METHODS: The PubMed database was searched using a query combining SLE and statins. RESULTS: The search yielded nine relevant clinical studies. Seven studies reported on radiological findings that correlate with atherosclerosis and mainly revealed that statin treatment resulted in a slight decrease in progression of carotid intima-media thickness and an increase in flow-mediated vasodilatation...
April 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28468767/cardiovascular-events-in-patients-with-mild-autonomous-cortisol-secretion-analysis-with-artificial-neural-networks
#18
Valentina Morelli, Serena Palmieri, Andrea Lania, Alberto Tresoldi, Sabrina Corbetta, Elisa Cairoli, Cristina Eller-Vainicher, Maura Arosio, Massimiliano Copetti, Enzo Grossi, Iacopo Chiodini
BACKGROUND: The independent role of mild autonomous cortisol secretion (ACS) in influencing the cardiovascular event (CVE) occurrence is a topic of interest. We investigated the role of mild ACS in the CVE occurrence in patients with adrenal incidentaloma (AI) by the standard statistics and the artificial neural networks (ANNs). METHODS: We analyzed a retrospective record of 518 AI patients. Data regarding cortisol levels after 1mg-dexamethasone suppression (1-mgDST) and the presence of obesity (OB), hypertension (AH), type-2 diabetes (T2DM), dyslipidaemia (DL), familial CVE history, smoking habit and CVE were collected...
May 3, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28451932/comparison-of-effects-of-sleeve-gastrectomy-and-gastric-bypass-on-lipid-profile-parameters-in-indian-obese-a-case-matched-analysis
#19
P Praveen Raj, Siddhartha Bhattacharya, S Saravana Kumar, Sandeep C Sabnis, R Parthasarathi, Parimala Devi Kumara Swamy, C Palanivelu
BACKGROUND: Obesity is associated with increased mortality due to higher cardiovascular risk. A proportion of this risk is attributed to impaired lipid profile in the form of high levels of serum total cholesterol, triglycerides, and low levels of HDL cholesterol. Both sleeve gastrectomy (LSG) and gastric bypass (LGB) have been shown to have favourable effects on lipid profile with some variability in improvement. We aimed to study the difference in changes in lipid profile after LSG and LGB...
April 28, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28442252/approaches-towards-the-development-of-chimeric-dpp4-ace-inhibitors-for-treating-metabolic-syndrome
#20
Jitendra A Sattigeri, Sachin Sethi, Joseph A Davis, Shahadat Ahmed, Geeta V Rayasam, Balasaheb G Jadhav, Satya M Chilla, Dhrubajyoti Datta, A Gadhave, Vamshi K Tulasi, Tarun Jain, Sreedhara Voleti, Biju Benjamin, Sunitha Udupa, Garima Jain, Yogender Singh, Kona Srinivas, Vinay S Bansal, Abhijit Ray, Pradip K Bhatnagar, Ian A Cliffe
Designing drug candidates exhibiting polypharmacology is one of the strategies adopted by medicinal chemists to address multifactorial diseases. Metabolic disease is one such multifactorial disorder characterized by hyperglycaemia, hypertension and dyslipidaemia among others. In this paper we report a new class of molecular framework combining the pharmacophoric features of DPP4 inhibitors with those of ACE inhibitors to afford potent dual inhibitors of DPP4 and ACE.
April 13, 2017: Bioorganic & Medicinal Chemistry Letters
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