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https://www.readbyqxmd.com/read/29912318/bayesian-inference-for-network-meta-regression-using-multivariate-random-effects-with-applications-to-cholesterol-lowering-drugs
#1
Hao Li, Ming-Hui Chen, Joseph G Ibrahim, Sungduk Kim, Arvind K Shah, Jianxin Lin, Andrew M Tershakovec
Low-density lipoprotein cholesterol (LDL-C) has been identified as a causative factor for atherosclerosis and related coronary heart disease, and as the main target for cholesterol- and lipid-lowering therapy. Statin drugs inhibit cholesterol synthesis in the liver and are typically the first line of therapy to lower elevated levels of LDL-C. On the other hand, a different drug, Ezetimibe, inhibits the absorption of cholesterol by the small intestine and provides a different mechanism of action. Many clinical trials have been carried out on safety and efficacy evaluation of cholesterol lowering drugs...
April 18, 2018: Biostatistics
https://www.readbyqxmd.com/read/29911253/dha-selectively-protects-samp-8-associated-cognitive-deficits-through-inhibition-of-jnk
#2
S Vela, Neira Sainz, María J Moreno-Aliaga, M Solas, María J Ramirez
A potential role of marine n-3 polyunsaturated fatty acids (ω-3 PUFAs) has been suggested in memory, learning, and cognitive processes. Therefore, ω-3 PUFAs might be a promising treatment option, albeit controversial, for Alzheimer's disease (AD). Among the different mechanisms that have been proposed as responsible for the beneficial effects of ω-3 PUFAs, inhibition of JNK stands as a particularly interesting candidate. In the present work, it has been studied whether the administration of two different PUFAs (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) and a DHA-derived specialized pro-resolving lipid mediator (MaR1) is able to reverse cognitive deficits in the senescence-accelerated mouse prone 8 (SAMP8) mouse model of sporadic AD...
June 17, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29910778/effects-of-1-8-cineole-on-carbohydrate-metabolism-related-cell-structure-changes-of-salmonella
#3
Yangying Sun, Xiaojun Cai, Jinxuan Cao, Zhen Wu, Daodong Pan
Salmonella is gram-negative foodborne zoonotic bacteria which triggers disease in humans. Our previous studies showed 1,8-cineole possessed remarkable antimicrobial effects on foodborne zoonotic bacteria indicating it could serve as a new source of antibiotic for Salmonella . Present study elucidated the antibacterial mechanism of 1,8-cineole by analyzing serum protein expressed by Salmonella following treatment with 1,8-cineole (0.25 mg/mL, 3 h) using isobaric tags for relative and absolute quantification (iTRAQ) with two-dimensional liquid chromatography/tandem mass spectrometry (2D-LC-MS/MS)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29909078/anti-inflammatory-nitro-fatty-acids-suppress-tumor-growth-by-triggering-mitochondrial-dysfunction-and-activation-of-the-intrinsic-apoptotic-pathway-in-colorectal-cancer-cells
#4
Benjamin Kühn, Camilla Brat, Jasmin Fettel, Nadine Hellmuth, Isabelle V Maucher, Ufuk Bulut, Katharina J Hock, Jennifer Grimmer, Georg Manolikakes, Michael Rühl, Alessa Kühn, Kai Zacharowski, Carmela Matrone, Anja Urbschat, Jessica Roos, Dieter Steinhilber, Thorsten J Maier
Nitro-fatty acids (NFAs) are endogenously occurring lipid mediators exerting strong anti-inflammatory effects and acting as anti-oxidants in a number of animal models of inflammation. These NFA effects are mediated by targeting important regulatory proteins involved in inflammatory processes, such as 5-lipoxygenase, soluble epoxide hydrolase, or NF-κB. In the present study, we investigated the anti-tumorigenic effects of NFAs on colorectal cancer (CRC) cells in cell culture-based experiments and in a murine xenograft model of human CRC...
June 14, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29908939/delivery-system-for-budesonide-based-on-lipid-dna
#5
Yun Liu, I Sophie T Bos, Tjitske A Oenema, Herman Meurs, Harm Maarsingh, Anna K H Hirsch
Budesonide is a hydrophobic glucocorticoid with high anti-inflammatory activity for the treatment of asthma, inflammatory bowel disease and rheumatoid arthritis. A micellar drug-delivery system based on lipid-DNA may provide a strategy to maximize its drug efficacy and reduce adverse effects. In this work, we report the use of lipid-DNA (UU11mer), featuring two hydrophobic alkyl chains and forming micelles at a comparatively low critical micelle concentration, to render budesonide water-soluble with a high loading capacity (LC)...
June 14, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29908368/tag-synthesis-and-storage-under-osmotic-stress-a-requirement-for-preserving-membrane-homeostasis-in-renal-cells
#6
Karen Weber, Cecilia Casali, Virginia Gaveglio, Susana Pasquaré, Emanuel Morel Gómez, Leandro Parra, Luciana Erjavec, Cecilia Perazzo, María C Fernández Tome
Hyperosmolarity is a controversial signal for renal cells. It can induce cell stress or differentiation and both require an active lipid metabolism. We showed that hyperosmolarity upregulates phospholipid (PL) de novo synthesis in renal cells. PL synthesis requires fatty acids (FA), usually stored as triglycerides (TAG). PL and TAG de novo synthesis utilize the same initial biosynthetic route: sn-glycerol 3P (G3P) → phosphatidic acid (PA) → diacylglycerol (DAG). In the present work, we evaluate how such pathway contributes to PL and TAG synthesis in renal cells subjected to hyperosmolarity...
June 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29907450/altered-maternal-and-placental-lipid-metabolism-and-fetal-fat-development-in-obesity-current-knowledge-and-advances-in-non-invasive-assessment
#7
Flavien Delhaes, Stephanie A Giza, Tianna Koreman, Genevieve Eastabrook, Charles A McKenzie, Samantha Bedell, Timothy R H Regnault, Barbra de Vrijer
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk...
May 26, 2018: Placenta
https://www.readbyqxmd.com/read/29906686/lipidated-%C3%AE-%C3%AE-aa-heterogeneous-peptides-as-antimicrobial-agents
#8
Sylvia Singh, Alekhya Nimmagadda, Ma Su, Minghui Wang, Peng Teng, Jianfeng Cai
With an increase of resistance in bacteria there is an urgent need for alternative treatment methods that could complement conventional antibiotics. In the past two decades, focus has been drawn to Host Defense Peptides (HDPs) as potential antibiotic agents. Herein we reported our studies on the development of lipidated α/α-AA heterogeneous peptides as a new class of HDP mimetics. These compounds showed potent antimicrobial activity toward both Gram-positive and Gram-negative bacteria, and they also displayed excellent selectivity as they only exhibited limited hemolytic activity...
June 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29902763/synergistic-effect-of-rapamycin-and-metformin-against-germ-cell-apoptosis-and-oxidative-stress-after-testicular-torsion-detorsion-induced-ischemia-reperfusion-in-rats
#9
Morteza Ghasemnejad-Berenji, Mahmoud Ghazi-Khansari, Sarvin Pashapour, Abbas Jafari, Iraj Yazdani, Hojjat Ghasemnejad-Berenji, Seyed Soheil Saeedi Saravi, Sonia Sadeghpour, Maliheh Nobakht, Alireza Abdollahi, Javad Mohajer Ansari, Ahmad Reza Dehpour
The aim of this study was to investigate the effects of rapamycin (rapa) and metformin (met), combined administration on testicular torsion-detorsion (T/D) injury. A total of 108 male rats were divided randomly into six groups (n = 18), control, sham-operated, T/D, T/D + met (100 mg/kg), T/D + rapa (0.25 mg/kg) and T/D + met (100 mg/kg)+rapa (0.25 mg/kg). Except for the control and sham groups, torsion was created by rotating the right testis 720° in a clockwise direction for 1 h...
June 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29902662/acrolein-induced-autophagy-dependent-apoptosis-via-activation-of-the-lysosomal-mitochondrial-pathway-in-eahy926-cells
#10
Songsong Luo, Liping Jiang, Qiannan Li, Xiance Sun, Ting Liu, Fuyang Pei, Tianjiao Zhang, Tiehong Liu, Linlin Dong, Xiaofang Liu, Lijie Jiang
Acrolein, a highly reactive α,β-unsaturated aldehyde, is a toxic component of cigarette smoke. As a lipid peroxidation biomarker, acrolein plays an important role in a wide variety of disease states, such as neurodegenerative, Alzheimer's disease, diabetes and atherosclerosis. Endothelial cell injury is one of the initiating factors of atherosclerosis, but the underlying molecular mechanisms remain unclear. Our study primarily focused on acrolein-induced autophagy-dependent apoptosis and the possible molecular mechanism...
June 11, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29898754/metformin-inhibits-stromal-aromatase-expression-and-tumor-progression-in-a-rodent-model-of-postmenopausal-breast-cancer
#11
Erin D Giles, Sonali Jindal, Elizabeth A Wellberg, Troy Schedin, Steven M Anderson, Ann D Thor, Dean P Edwards, Paul S MacLean, Pepper Schedin
BACKGROUND: Obesity and type II diabetes are linked to increased breast cancer risk in postmenopausal women. Patients treated with the antidiabetic drug metformin for diabetes or metabolic syndrome have reduced breast cancer risk, a greater pathologic complete response to neoadjuvant therapy, and improved breast cancer survival. We hypothesized that metformin may be especially effective when targeted to the menopausal transition, as this is a lifecycle window when weight gain and metabolic syndrome increase, and is also when the risk for obesity-related breast cancer increases...
June 14, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29897025/comparative-effectiveness-and-safety-between-amphotericin-b-lipid-formulations-a-systematic-review
#12
Luiza Raquel Grazziotin, Leila Beltrami Moreira, Maria Angelica Pires Ferreira
OBJECTIVES: It is not yet established the advantages between amphotericin B lipid complex (ABLC) and liposomal (L-AmB) in patients with invasive fungal infections refractory to usual doses of conventional AmB (d-AmB), previous renal impairment, or unacceptable d-AmB renal toxicity. This systematic review aims to compare ABLC and L-AmB effectiveness and safety outcomes in these subgroups of patients. METHODS: The search was performed on Medline, Cochrane Library, EMBASE, and LILACS databases...
June 13, 2018: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29896206/rna-and-mrna-nitration-as-a-novel-metabolic-link-in-potato-immune-response-to-phytophthora-infestans
#13
Karolina Izbiańska, Jolanta Floryszak-Wieczorek, Joanna Gajewska, Barbara Meller, Daniel Kuźnicki, Magdalena Arasimowicz-Jelonek
Peroxynitrite (ONOO- ) exhibits a well-documented nitration activity in relation to proteins and lipids; however, the interaction of ONOO- with nucleic acids remains unknown in plants. The study uncovers RNA and mRNA nitration as an integral event in plant metabolism intensified during immune response. Using potato- avr/vr Phytophthora infestans systems and immunoassays we documented that potato immunity is accompanied by two waves of boosted ONOO- formation affecting guanine nucleotides embedded in RNA/mRNA and protein tyrosine residues...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29895458/application-of-mesocellular-siliceous-foams-mcf-for-surface-assisted-laser-desorption-ionization-mass-spectrometry-saldi-ms-analysis-of-fingermarks
#14
R M Barros, M C H Clemente, G A V Martins, L P Silva
Recent advances in nanotechnology applied in forensic sciences have contributed to consider new approaches including chemical evaluation of latent fingermarks. Significant improvement to the detection of small organic molecules has been reached with matrix-free methods associated to laser desorption/ionization mass spectrometry. The present study investigated the application of mesocellular siliceous foam (MCF) as an ionizing agent for laser desorption/ionization (LDI-MS) analysis of fingermarks as a proof of concept research...
July 2018: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/29891721/chemoproteomics-reveals-baicalin-activates-hepatic-cpt1-to-ameliorate-diet-induced-obesity-and-hepatic-steatosis
#15
Jianye Dai, Kai Liang, Shan Zhao, Wentong Jia, Yuan Liu, Hongkun Wu, Jia Lv, Chen Cao, Tao Chen, Shentian Zhuang, Xiaomeng Hou, Shijie Zhou, Xiannian Zhang, Xiao-Wei Chen, Yanyi Huang, Rui-Ping Xiao, Yan-Ling Wang, Tuoping Luo, Junyu Xiao, Chu Wang
Obesity and related metabolic diseases are becoming worldwide epidemics that lead to increased death rates and heavy health care costs. Effective treatment options have not been found yet. Here, based on the observation that baicalin, a flavonoid from the herbal medicine Scutellaria baicalensis , has unique antisteatosis activity, we performed quantitative chemoproteomic profiling and identified carnitine palmitoyltransferase 1 (CPT1), the controlling enzyme for fatty acid oxidation, as the key target of baicalin...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29891362/a-new-herbicidal-site-of-action-cinmethylin-binds-to-acyl-acp-thioesterase-and-inhibits-plant-fatty-acid-biosynthesis
#16
Ruth Campe, Eva Hollenbach, Lara Kämmerer, Janneke Hendriks, Hans Wolfgang Höffken, Helmut Kraus, Jens Lerchl, Thomas Mietzner, Stefan Tresch, Matthias Witschel, Johannes Hutzler
The prevalent occurrence of herbicide resistant weeds increases the necessity for new site of action herbicides for effective control as well as to relax selection pressure on the known sites of action. As a consequence, interest increased in the unexploited molecule cinmethylin as a new solution for the control of weedy grasses in cereals. Therefore, the mechanism of action of cinmethylin was reevaluated. We applied the chemoproteomic approach cellular Target Profiling™ from Evotec to identify the cinmethylin target in Lemna paucicostata protein extracts...
June 2018: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29890972/molecular-evaluation-of-anti-inflammatory-activity-of-phenolic-lipid-extracted-from-cashew-nut-shell-liquid-cnsl
#17
Marilen Queiroz de Souza, Isabella Márcia Soares Nogueira Teotônio, Fernanda Coutinho de Almeida, Gabriella Simões Heyn, Priscilla Souza Alves, Luiz Antônio Soares Romeiro, Riccardo Pratesi, Yanna Karla de Medeiros Nóbrega, Claudia B Pratesi
BACKGROUND: Anacardium occidentale L phenolic lipid (LDT11) is used in traditional medicine as anti-inflammatory, astringent, antidiarrheal, anti-asthmatic and depurative. Phenolic derivatives, such as anacardic acid, extracted from cashew nut shell liquid (CNSL) have demonstrated biological and pharmacological properties, and its profile makes it a candidate for the development of new anti-inflammatory agents. The objective of the present study was to evaluate the anti-inflammatory profile of a derivative, synthesized from LDT11, on an in vitro cellular model...
June 11, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29889764/long-term-outcomes-of-elagolix-in-women-with-endometriosis-results-from-two-extension-studies
#18
Eric Surrey, Hugh S Taylor, Linda Giudice, Bruce A Lessey, Mauricio S Abrao, David F Archer, Michael P Diamond, Neil P Johnson, Nelson B Watts, J Chris Gallagher, James A Simon, Bruce R Carr, W Paul Dmowski, Nicholas Leyland, Sukhbir S Singh, Tomasz Rechberger, Sanjay K Agarwal, W Rachel Duan, Brittany Schwefel, James W Thomas, Paul M Peloso, Juki Ng, Ahmed M Soliman, Kristof Chwalisz
OBJECTIVE: To evaluate the efficacy and safety of elagolix, an oral, nonpeptide gonadotropin-releasing hormone antagonist, over 12 months in women with endometriosis-associated pain. METHODS: Elaris Endometriosis (EM)-III and -IV were extension studies that evaluated an additional 6 months of treatment after two 6-month, double-blind, placebo-controlled phase 3 trials (12 continuous treatment months) with two elagolix doses (150 mg once daily and 200 mg twice daily)...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29886715/recent-advances-in-primary-and-secondary-prevention-of-atherosclerotic-stroke
#19
Georgios Tsivgoulis, Apostolos Safouris, Dong-Eog Kim, Andrei V Alexandrov
Atherosclerosis is a major cause of ischemic stroke that can be effectively prevented with appropriate lifestyle modifications and control of cardiovascular risk factors. Medical advances in recent years along with aggressive cardiovascular risk factor modifications have resulted in decreased recurrence rates of atherosclerotic stroke. Non-statin lipid-lowering molecules have recently shown clinical benefit and are recommended for very high-risk patients to reduce their risk of stroke. Aggressive hypertension treatment is crucial to reduce atherosclerotic stroke risk...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29885369/the-relationship-of-endocannabinoidome-lipid-mediators-with-pain-and-psychological-stress-in-women-with-fibromyalgia-a-case-control-study
#20
Niclas Stensson, Nazdar Ghafouri, Malin Ernberg, Kaisa Mannerkorpi, Eva Kosek, Björn Gerdle, Bijar Ghafouri
Characterized by chronic widespread pain, generalized hyperalgesia, and psychological stress fibromyalgia (FM) is difficult to diagnose and lacks effective treatments. The endocannabinoids - arachidonoylethanolamide (AEA), 2-arachidonoylglycerol (2-AG), and the related oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and stearoylethanolamide (SEA) - are endogenous lipid mediators with analgesic and anti-inflammatory characteristics, in company with psychological modulating properties (e.g., stress and anxiety), and are included in a new emerging "ome", the endocannabinoidome...
June 6, 2018: Journal of Pain: Official Journal of the American Pain Society
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