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https://www.readbyqxmd.com/read/28289046/observational-study-of-the-development-and-evaluation-of-a-fertility-preservation-patient-decision-aid-for-teenage-and-adult-women-diagnosed-with-cancer-the-cancer-fertility-and-me-research-protocol
#1
G L Jones, J Hughes, N Mahmoodi, D Greenfield, G Brauten-Smith, J Skull, J Gath, D Yeomanson, E Baskind, J A Snowden, R M Jacques, G Velikova, K Collins, D Stark, R Phillips, S Lane, H L Bekker
INTRODUCTION: Women diagnosed with cancer and facing potentially sterilising cancer treatment have to make time-pressured decisions regarding fertility preservation with specialist fertility services while undergoing treatment of their cancer with oncology services. Oncologists identify a need for resources enabling them to support women's fertility preservation decisions more effectively; women report wanting more specialist information to make these decisions. The overall aim of the 'Cancer, Fertility and Me' study is to develop and evaluate a new evidence-based patient decision aid (PtDA) for women with any cancer considering fertility preservation to address this unmet need...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28284221/uptake-of-hormonal-contraceptives-and-correlates-of-uptake-in-a-phase-iii-clinical-trial-in-rural-south-western-uganda
#2
Andrew Abaasa, Mitzy Gafos, Zacchaeus Anywaine, Andrew Nunn, Angela Crook, Jonathan Levin, Sheena McCormack, Anatoli Kamali
BACKGROUND: Use of a reliable contraception method has become an inclusion criterion in prevention trials to minimize time off product. We report on hormonal contraceptive prevalence, uptake, sustained use and correlates of use in the Microbicides Development Programme (MDP 301) trial at the Masaka Centre in Uganda. METHODS: HIV negative women in sero-discordant relationships were enrolled and followed-up for 52 to 104 weeks from 2005 to 2009. Contraceptive use data was collected through self-report at baseline and dispensing records during follow-up...
March 11, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28275453/insight-into-hiv-2-latency-may-disclose-strategies-for-a-cure-for-hiv-1-infection
#3
EDITORIAL
Suha Saleh, Lenard Vranckx, Rik Gijsbers, Frauke Christ, Zeger Debyser
HIV-1 and HIV-2 originate from two distinct zoonotic transmissions of simian immunodeficiency viruses from primate to human. Although both share similar modes of transmission and can result in the development of AIDS with similar clinical manifestations, HIV-2 infection is generally milder and less likely to progress to AIDS. HIV is currently incurable due to the presence of HIV provirus integrated into the host DNA of long-lived memory cells of the immune system without active replication. As such, the latent virus is immunologically inert and remains insensitive to the administered antiviral drugs targeting active viral replication steps...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28262036/the-effect-of-simulated-flash-heating-pasteurisation-and-holder-pasteurisation-on-human-milk-oligosaccharides
#4
Brodie Daniels, Anna Coutsoudis, Chloe Autran, Kimberly Amundson Mansen, Kiersten Israel-Ballard, Lars Bode
BACKGROUND: Human milk oligosaccharides (HMOs) have important protective functions in human milk. A low-cost remote pasteurisation temperature-monitoring system has been designed using FoneAstra, a cell phone-based networked sensing system to monitor simulated flash heat pasteurisation. AIM: To compare the pasteurisation effect on HMOs of the FoneAstra FH method with the current Sterifeed Holder method used by human milk banks. METHODS: Donor human milk samples (n = 48) were obtained from a human milk bank and pasteurised using the two pasteurisation methods...
March 6, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28246094/bactericidal-and-antimicrobial-effects-of-pure-titanium-and-titanium-alloy-treated-with-short-term-low-energy-uv-irradiation
#5
T Itabashi, K Narita, A Ono, K Wada, T Tanaka, G Kumagai, R Yamauchi, A Nakane, Y Ishibashi
OBJECTIVES: The surface of pure titanium (Ti) shows decreased histocompatibility over time; this phenomenon is known as biological ageing. UV irradiation enables the reversal of biological ageing through photofunctionalisation, a physicochemical alteration of the titanium surface. Ti implants are sterilised by UV irradiation in dental surgery. However, orthopaedic biomaterials are usually composed of the alloy Ti6Al4V, for which the antibacterial effects of UV irradiation are unconfirmed...
February 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28240569/selected-questions-and-controversies-about-bedaquiline-a-view-from-the-field
#6
K Dheda, A Esmail, J Limberis, G Maartens
Although there has been a slow decline in tuberculosis (TB) incidence worldwide, the prevalence of drug-resistant TB in most high-burden countries has increased. Drug-resistant TB is associated with high mortality, is a threat to health care workers in TB-endemic countries and is prohibitively costly, which diverts resources away from drug-susceptible cases. Amplification of resistance means that there is an increasing proportion of patients with multidrug-resistant TB who have extensively drug-resistant TB (XDR-TB) or are programmatically untreatable...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28213100/effect-of-processing-conditions-of-dicalcium-phosphate-cements-on-graft-resorption-and-bone-formation
#7
Zeeshan Sheikh, Yu Ling Zhang, Faleh Tamimi, Jake Barralet
Dicalcium phosphate cements (brushite and monetite) are resorbable biomaterials with osteoconductive potential for bone repair and regeneration that have yet to gain widespread commercial use. Brushite can be converted to monetite by heat treatments additionally resulting in various changes in the physico-chemical properties. However, since conversion is most commonly performed using autoclave sterilisation (wet heating), it is uncertain whether the properties observed for monetite as a result of heating brushite under dry conditions affect resorption and bone formation favourably...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28176143/microbacterium-zeae-sp-nov-an-endophytic-bacterium-isolated-from-maize-stem
#8
Jun-Lian Gao, Pengbo Sun, Xu-Ming Wang, Fan-Yang Lv, Jian-Guang Sun
A novel Gram-stain positive, aerobic, non-motile, non-spore-forming and rod-shaped strain designated 1204(T) was isolated from surface-sterilised stem tissue of maize planted in Fangshan District of Beijing, People's Republic of China. A polyphasic taxonomic study was performed on the new isolate. On the basis of 16S rRNA gene sequence similarity studies, this isolate belongs to the genus Microbacterium. High levels of 16S rRNA gene sequence similarity were found between strain 1204(T) and Microbacterium enclense NIO-1002(T) (98...
February 7, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28160353/a-review-on-microbiological-decontamination-of-fresh-produce-with-nonthermal-plasma
#9
REVIEW
C Pignata, D D'Angelo, E Fea, G Gilli
Food safety is a critical public health issue for consumers and the food industry because microbiological contamination of food causes considerable social and economic burdens on health care. Most foodborne illness comes from animal production, but as of the mid-1990s in the United States and more recently in the European Union, the contribution of fresh produce to foodborne outbreaks has rapidly increased. Recent studies have suggested that sterilisation with nonthermal plasma could be a viable alternative to the traditional methods for the decontamination of heat-sensitive materials or food because this technique proves capable of eliminating microorganisms on surfaces without altering the substrate...
February 4, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28159538/the-effect-of-systemic-lipoic-acid-on-hearing-preservation-after-cochlear-implantation-via-the-round-window-approach-a-guinea-pig-model
#10
Mun Young Chang, Tae Mok Gwon, Ho Sun Lee, Jun Ho Lee, Seung Ha Oh, Sung June Kim, Min-Hyun Park
The present study aimed to evaluate the effects of systemic lipoic acid on hearing preservation after cochlear implantation. Twelve Dunkin-Hartley guinea pigs were randomly divided into two groups: the control group and the lipoic acid group. Animals in the lipoic acid group received lipoic acid intraperitoneally for 4 weeks. A sterilised silicone electrode-dummy was inserted through the round window to a depth of approximately 5 mm. The hearing level was measured using auditory brainstem responses (ABRs) prior to electrode-dummy insertion, and at 4 days and 1, 2, 3 and 4 weeks after electrode-dummy insertion...
January 31, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28155290/the-diagnosis-of-bilateral-primary-renal-paragangliomas-in-a-cat
#11
Ryan B Friedlein, Alain J Carter, Robert D Last, Sarah Clift
A 9-year-old sterilised female domestic short-hair cat was referred with a history of vomiting and anorexia of 3 months' duration. Biochemistry, full-blood counts, thoracic radiographs, feline pancreatic-specific lipase, abdominal ultrasonography and feline immunodeficiency virus/feline leukaemia virus (FIV/FeLV) SNAP tests had been performed. Mild hypochloraemia and moderate hypokalaemia were evident on initial presentation. Abdominal ultrasonography initially revealed unilateral renal nodules on the left side...
January 24, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/28130284/metastatic-endometrial-endometrioid-carcinoma-mimicking-pilomatrixoma-of-the-distal-vagina
#12
Simon M Scheck, Peter Bethwaite, Carol Johnson, Ole Mogensen
Endometrioid carcinoma with a prominent squamous component has the ability to mimic pilomatrixoma. One previous case is documented of cutaneous metastasis in the upper limb derived from ovarian endometrioid carcinoma mimicking pilomatrixoma. Here, we describe a case of metastasis of endometrial endometrioid carcinoma in the distal vagina, treated with radiotherapy and later resected. The histology of the lesion was thought initially to represent pilomatrixoma; this has not previously been described in the vagina, where no hair matrix cells are normally present...
January 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28124665/acute-reactions-to-polysulfone-polyethersulfone-dialysers-literature-review-and-management
#13
W H Boer, Y Liem, E de Beus, A C Abrahams
Acute dialyser reactions in patients treated by haemodialysis are uncommon. We present two cases of such reactions, both in patients using a polysulfone, steam-sterilised dialyser. Patient 1 suffered from recurrent attacks of acute dyspnoea, hypoxia and hypotension that occurred early in dialysis sessions, whereas patient 2 presented with unexplained episodes of severe hypotension and vomiting in the initial phases of dialysis. After switching to a cellulose triacetate dialyser, both patients became asymptomatic during all subsequent dialysis sessions, but intentional (patient 1) and accidental (patient 2) rechallenge with the polysulfone dialyser induced an immediate recurrence of the symptoms...
January 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28109709/the-effect-of-gamma-irradiation-conditions-on-the-immunogenicity-of-whole-inactivated-influenza-a-virus-vaccine
#14
Shannon C David, Josyane Lau, Eve V Singleton, Rachelle Babb, Justin Davies, Timothy R Hirst, Shaun R McColl, James C Paton, Mohammed Alsharifi
Gamma-irradiation, particularly an irradiation dose of 50kGy, has been utilised widely to sterilise highly pathogenic agents such as Ebola, Marburg Virus, and Avian Influenza H5N1. We have reported previously that intranasal vaccination with a gamma-irradiated Influenza A virus vaccine (γ-Flu) results in cross-protective immunity. Considering the possible inclusion of highly pathogenic Influenza strains in future clinical development of γ-Flu, an irradiation dose of 50kGy may be used to enhance vaccine safety beyond the internationally accepted Sterility Assurance Level (SAL)...
January 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28103896/sexual-and-reproductive-health-services-utilization-by-female-sex-workers-is-context-specific-results-from-a-cross-sectional-survey-in-india-kenya-mozambique-and-south-africa
#15
Yves Lafort, Ross Greener, Anuradha Roy, Letitia Greener, Wilkister Ombidi, Faustino Lessitala, Jolene Skordis-Worrall, Mags Beksinska, Peter Gichangi, Sushena Reza-Paul, Jenni A Smit, Matthew Chersich, Wim Delva
BACKGROUND: Female sex workers (FSWs) are extremely vulnerable to adverse sexual and reproductive health (SRH) outcomes. To mitigate these risks, they require access to services covering not only HIV prevention but also contraception, cervical cancer screening and sexual violence. To develop context-specific intervention packages to improve uptake, we identified gaps in service utilization in four different cities. METHODS: A cross-sectional survey was conducted, as part of the baseline assessment of an implementation research project...
January 19, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28062651/an-activist-s-argument-that-participant-values-should-guide-risk-benefit-ratio-calculations-in-hiv-cure-research
#16
David Evans
The patient empowerment movement, spurred by AIDS activism in the 1980s, quickly evolved to encompass how study participants are considered and treated in clinical research. Initially, people fearing death of AIDS sought early access to experimental medications that had not undergone rigorous testing in hopes of extending their lives. Thirty years on, scientists are asking a different set of ethical questions about clinical research, this time in the pursuit of either a sterilising cure or long-term remission for HIV...
February 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28013184/variables-determining-mortality-in-patients-with-acinetobacter-baumannii-meningitis-ventriculitis-treated-with-intrathecal-colistin
#17
Bahadır Ceylan, Ferhat Arslan, Oguz Resat Sipahi, Mustafa Sunbul, Bahar Ormen, İsmail N Hakyemez, Tuba Turunc, Yeşim Yıldız, Hasan Karsen, Gul Karagoz, Recep Tekin, Burcu Hizarci, Vedat Turhan, Sebnem Senol, Nefise Oztoprak, Mesut Yılmaz, Kevser Ozdemir, Sinan Mermer, Omer F Kokoglu, Ali Mert
AIM: To examine the variables associated with mortality in patients with Acinetobacter baumannii-related central nervous system infections treated with intrathecal colistin. MATERIALS AND METHODS: This multi-centre retrospective case control study included patients from 11 centres in Turkey, as well as cases found during a literature review. Only patients with CNS infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii treated with intrathecal colistin were included in this study...
February 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28007820/curbing-publicly-funded-family-planning-services-in-iran-who-is-affected
#18
Amir Erfani
OBJECTIVE: In response to a persistent low fertility rate in the country, the Supreme Leader of Iran in 2012 called for the shift to pronatalist population policies. Consequently, Iran's Parliament proposed a bill to curb the provision of contraceptive knowledge and services as a solution to raising the country's low fertility rate. This study aimed to investigate which groups of women will be adversely affected if the provision of subsidised contraceptive methods [i.e. sterilisation, intrauterine device (IUD) and injections] is curbed...
January 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/27998332/-electroshock-therapy-in-the-third-reich
#19
Lara Rzesnitzek, Sascha Lang
The history of 'electroshock therapy' (now known as electroconvulsive therapy (ECT)) in Europe in the Third Reich is still a neglected chapter in medical history. Since Thomas Szasz's 'From the Slaughterhouse to the Madhouse', prejudices have hindered a thorough historical analysis of the introduction and early application of electroshock therapy during the period of National Socialism and the Second World War. Contrary to the assumption of a 'dialectics of healing and killing', the introduction of electroshock therapy in the German Reich and occupied territories was neither especially swift nor radical...
January 2017: Medical History
https://www.readbyqxmd.com/read/27951560/new-dialysis-technology-and-biocompatible-materials
#20
Andrew Davenport
Although haemodialysis is an established treatment for patients with end-stage kidney disease, sustaining life for more than 2 million patients world-wide, the mortality of dialysis patients remains high and is greater than that for some of the more common solid organ cancers. As such, the question arises as to whether more efficient clearance of the waste products of metabolism which accumulate would improve outcomes. Recent reports of an association between improved patient survivals with higher-volume on-line haemodiafiltration exchanges would support this hypothesis...
2017: Contributions to Nephrology
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