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Asthma biomarker

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https://www.readbyqxmd.com/read/28332366/soluble-cd93-in-serum-as-a-marker-of-allergic-inflammation
#1
Hye Jung Park, Heejae Han, Sang Chul Lee, Young Woong Son, Da Woon Sim, Kyung Hee Park, Yoon Hee Park, Kyoung Yong Jeong, Jung Won Park, Jae Hyun Lee
PURPOSE: CD93 is receiving renewed attention as a biomarker of inflammation. We aimed to evaluate the potential for serum sCD93 to serve as a novel biomarker for allergic inflammation. MATERIALS AND METHODS: We enrolled 348 subjects with an allergic disease [allergic rhinitis (AR), chronic spontaneous urticaria (CSU), or bronchial asthma (BA)], including 14 steroid-naïve BA patients who were serially followed-up. RESULTS: The serum sCD93 levels (ng/mL) in patients with exacerbated AR (mean±standard deviation, 153...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28320793/rct-of-the-effect-of-berryfruit-polyphenolic-cultivar-extract-in-mild-steroid-naive-asthma-a-cross-over-placebo-controlled-study
#2
Sharon Power, Mathew Williams, Alex Semprini, Claire Munro, Rachel Caswell-Smith, Janine Pilcher, Mark Holliday, James Fingleton, Jacquie Harper, Roger Hurst, Mark Weatherall, Richard Beasley, Irene Braithwaite
OBJECTIVE: There is preclinical evidence that consumption of berryfruit extract may reduce chronic airways inflammation and modify airway remodelling in allergen-induced models of lung inflammation. We investigated the effect of berryfruit extract on the fractional expired nitric oxide (FeNO), a biomarker of eosinophilic airways inflammation, in adults with steroid-naïve asthma. DESIGN: Randomised placebo-controlled cross-over double-blind trial. SETTING: Single-centre community-based trial...
March 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28319473/precision-medicine-in-asthma-the-role-of-bronchial-thermoplasty
#3
Amber J Oberle, Praveen Mathur
PURPOSE OF REVIEW: The inflammatory makeup of severe asthma is heterogeneous. Identification of the predominant cellular endotype via biomarkers can aid in the selection of more advanced therapies. This review is clinically focused on how to use these biomarkers to help select between biologic agents and/or bronchial thermoplasty. RECENT FINDINGS: Several Th2 biomarkers exist for the detection of eosinophilic disease; however, the best biomarker for clinical practice is debatable depending upon local resources...
March 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28306401/caregiver-s-depressive-symptoms-and-asthma-control-in-children-from-an-underserved-community
#4
Andrea Rioseco, Carolina Serrano, Juan C Celedón, Oslando Padilla, Klaus Puschel, Jose A Castro-Rodriguez
Caregiver's or maternal depression has been associated with increased asthma morbidity in children from prosperous nations, but little is known about this link in low and middle-income countries. OBJECTIVE: To examine if caregiver's depressive symptoms are associated with poor asthma control and abnormal immune responses in school-aged children. METHODS: Case-control study of 87 asthmatic children (aged 4-11 years) attending a primary care clinic in an underserved area of Santiago (Chile)...
February 13, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28298259/phenotypic-analysis-of-asthma-in-japanese-athletes
#5
Keisuke Tsukioka, Toshiyuki Koya, Hiroshi Ueno, Masachika Hayashi, Takuro Sakagami, Takashi Hasegawa, Masaaki Arakawa, Eiichi Suzuki, Toshiaki Kikuchi
BACKGROUND: Asthma in athlete populations such as Olympic athletes has various pathogeneses. However, few reports are available on the features of asthma in the athlete population in clinical practice. In this study, we focused on classifying asthma in Japanese athlete population. METHODS: We performed a cluster analysis of data from pulmonary function tests and clinical biomarkers before administering inhaled corticosteroids (ICS) therapy in athlete population of individuals diagnosed with asthma (n = 104; male, 76...
March 12, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28293414/galectin-3-an-early-predictive-biomarker-of-modulation-of-airway-remodeling-in-patients-with-severe-asthma-treated-with-omalizumab-for-36%C3%A2-months
#6
Anna Maria Riccio, Pierluigi Mauri, Laura De Ferrari, Rossana Rossi, Dario Di Silvestre, Louise Benazzi, Alessandra Chiappori, Roberto Walter Dal Negro, Claudio Micheletto, Giorgio Walter Canonica
BACKGROUND: Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined using nonspecific clinical and physiologic variables that encompass multiple phenotypes and are treated with nonspecific anti-inflammatory therapies. Based on the modulation of airway remodeling after 12 months of anti-immunoglobulin E (IgE) treatment, we identified two phenotypes (omalizumab responder, OR; and non-omalizumab responder, NOR) and performed morphometric analysis of bronchial biopsy specimens...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28293392/the-effect-of-hydro-ethanolic-extract-of-curcuma-longa-rhizome-and-curcumin-on-total-and-differential-wbc-and-serum-oxidant-antioxidant-biomarkers-in-rat-model-of-asthma
#7
Farzaneh Shakeri, Mohammad Soukhtanloo, Mohammad Hossein Boskabady
OBJECTIVES: The effects of Curcuma longa (C. longa) and curcumin on total and differential WBC count and oxidant, antioxidant biomarkers, in rat model of asthma were evaluated. MATERIALS AND METHODS: Total and differential WBC count in the blood, NO2, NO3, MDA, SOD, CAT and thiol levels in serum were examined in control, asthma, Asthmatic rats treated with C. longa (0.75, 1.50, and 3.00 mg/ml), curcumin (0.15, 0.30, and 0.60 mg/ml), and dexamethasone (1.25 μg/ml) rats...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28287417/the-effect-of-chinese-herbal-medicine-formula-mkg-on-allergic-asthma-by-regulating-lung-and-plasma-metabolic-alternations
#8
Meng Yu, Hong-Mei Jia, Feng-Xia Cui, Yong Yang, Yang Zhao, Mao-Hua Yang, Zhong-Mei Zou
Asthma is a chronic inflammatory disorder of the airway and is characterized by airway remodeling, hyperresponsiveness, and shortness of breath. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicines (TCM), has been demonstrated to have good therapeutic effects on experimental allergic asthma. However, its anti-asthma mechanism remains currently unknown. In the present work, metabolomics studies of biochemical changes in the lung tissue and plasma of ovalbumin (OVA)-induced allergic asthma mice with mKG treatment were performed using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS)...
March 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28287273/novel-monoclonal-treatments-in-severe-asthma
#9
Howraman Meteran, Hanieh Meteran, Celeste Porsbjerg, Vibeke Backer
AIM: To provide a general overview of the current biological treatments and discuss their potential anti-asthmatic effects. DATA SOURCES: We reviewed articles in PubMed found using the search words "Asthma/therapy AND antibodies, monoclonal/therapeutic use AND cytokines." STUDY SELECTIONS: Only articles published in English since 2000 were considered. The search identified 29 studies; 8 additional studies were found by hand search, generating 37 studies...
March 13, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28284319/longterm-clinical-outcomes-of-omalizumab-therapy-in-severe-allergic-asthma-study-of-efficacy-and-safety
#10
Adel H Mansur, Sapna Srivastava, Verity Mitchell, Julie Sullivan, Ismail Kasujee
Omalizumab has been shown to be an effective add-on therapy for patients with uncontrolled severe persistent allergic asthma. There has been a steady accumulation of evidence on the long-term effectiveness of omalizumab; however, data on real-life outcomes beyond one year of treatment is limited. In this study, we report on long-term outcomes of omalizumab treatment. We collected data from our severe asthma registry on hospitalisations, exacerbations, corticosteroid sparing, asthma control, lung function, biomarkers and side effects, to determine if the benefit was sustained and treatment was safe on the long term...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28283213/novel-biomarkers-in-severe-asthma
#11
Eleftherios Zervas, Konstantinos Samitas, Mina Gaga
No abstract text is available yet for this article.
March 7, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28272089/mediators-of-inflammation-in-asthma-a-forensic-perspective
#12
Maria Laura Schirripa, Maria Pia Scarpelli, Cristian Palmiere
In the clinical setting, the role of systemic inflammation in patients with asthma has attracted increased attention, and some authors showed that increased IL-6 and high-sensitivity C-reactive protein characterized a group of asthmatic patients. In the realm of forensic pathology, a postmortem diagnosis of asthmatic death can be extremely challenging. The aim of this study was to determine the postmortem serum levels of C-reactive protein, IL-6, and tumor necrosis factor α in a series of severe acute bronchial asthma deaths that underwent medicolegal investigations...
March 8, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28271730/recent-mass-spectrometry-based-proteomics-for-biomarker-discovery-in-lung-cancer-copd-and-asthma
#13
Kiyonaga Fujii, Haruhiko Nakamura, Toshihide Nishimura
Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease. Recent developments in mass spectrometry (MS) have made it possible to analyze disease-relevant proteins expressed in clinical specimens by proteomic challenges. Areas covered: To understand the molecular mechanisms of lung cancer and its subtypes, chronic obstructive pulmonary disease (COPD), asthma and others, great efforts have been taken to identify numerous relevant proteins by MS-based clinical proteomic approaches...
March 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28256388/utility-of-serum-periostin-in-combination-with-exhaled-nitric-oxide-in-the-management-of-asthma
#14
REVIEW
Tadao Nagasaki, Hisako Matsumoto, Kenji Izuhara
Type-2/eosinophilic inflammation plays a pivotal role in asthma. The identification of severe type-2/eosinophilic asthma is important for improving the management of patients with asthma. Therefore, efforts to develop non-invasive biomarkers for type-2/eosinophilic airway inflammation have been made during this decade. Currently, fraction of exhaled nitric oxide (FeNO) and serum periostin levels are considered markers of type-2/eosinophilic inflammation in asthma. However, a single-marker approach has limited the ability to diagnose severe type-2/eosinophilic asthma accurately and predict disease outcomes precisely...
February 27, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28253731/age-dependent-allergic-asthma-development-and-cystathionine-gamma-lyase-deficiency
#15
Peipei Wang, Lingyun Wu, Youngjun Ju, Ming Fu, Tian Shuang, Zhong Ming Qian, Rui Wang
<b>Aims:</b> Allergic asthma is more prevalent in children than in adults, for which the pathogenic mechanisms remain unclear. This study tested the hypothesis that age-dependent expression of H2S-generating enzyme, cystathionine gamma-lyase (CSE), underlies age-dependent development of allergic asthma. <b>Results:</b> Allergic asthma was induced with ovalbumin in wild-type (WT) and CSE knock-out (KO) mice at young and old ages. Young WT mice developed more severe asthmatic symptoms with higher type-2 immunoreaction than old WT mice, which resulted from lower levels of CSE expression and H2S production in immune cells of young WT mice than in old WT animals...
March 2, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28253520/fractional-exhaled-nitric-oxide-a-potential-biomarker-in-allergic-rhinitis
#16
Giorgio Ciprandi, Fabio Gallo, Fabio Luigi Massimo Ricciardolo, Ignazio Cirillo
BACKGROUND: The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. METHODS: A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Those patients with a high FeNO underwent a 2-year follow-up. RESULTS: Increased FeNO was associated with a significantly longer AR duration, impaired lung function, more severe symptoms, and more frequent bronchial hyperresponsiveness (BHR)...
March 3, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28248547/serum-periostin-as-a-biomarker-for-comorbid-chronic-rhinosinusitis-in-patients-with-asthma
#17
Takamitsu Asano, Yoshihiro Kanemitsu, Masaya Takemura, Makoto Yokota, Kensuke Fukumitsu, Norihisa Takeda, Hiroya Ichikawa, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yumi Maki, Junya Ono, Shoichiro Ohta, Yoshihisa Nakamura, Kenji Izuhara, Motohiko Suzuki, Akio Niimi
RATIONALE: Periostin is a matricellular protein that is involved in the pathophysiology of allergic rhinitis, chronic rhinosinusitis, and asthma. Associations of serum periostin with systemic and airway eosinophilic inflammation and comorbid chronic rhinosinusitis in patients with asthma have been demonstrated. Although serum periostin is positioned as a marker of helper T cell 2 (Th2) immune responses, its implication regarding the presence of comorbid upper airway diseases in patients with asthma remains unclear...
March 1, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28248008/can-biomarkers-help-us-hit-targets-in-difficult-to-treat-asthma
#18
REVIEW
Michael Fricker, Liam G Heaney, John W Upham
Biomarkers may be a key foundation for the precision medicine of the future. In this article, we review current knowledge regarding biomarkers in difficult-to-treat asthma and their ability to guide the use of both conventional asthma therapies and novel (targeted) therapies. Biomarkers (as measured by tests including prednisolone and cortisol assays and the fractional exhaled nitric oxide (NO) suppression test) show promise in the assessment and management of non-adherence to inhaled and oral corticosteroids...
April 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28238750/kif3a-genetic-variation-is-associated-with-pediatric-asthma-in-the-presence-of-eczema-independent-of-allergic-rhinitis
#19
Elisabet Johansson, Jocelyn M Biagini Myers, Lisa J Martin, Hua He, Valentina Pilipenko, Tesfaye Mersha, Matthew Weirauch, Nathan Salomonis, Patrick Ryan, Grace K LeMasters, David I Bernstein, James Lockey, Gurjit K Khurana Hershey
No abstract text is available yet for this article.
February 24, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28223794/airway-gene-expression-of-il-1-pathway-mediators-predicts-exacerbation-risk-in-obstructive-airway-disease
#20
Katherine J Baines, Juan-Juan Fu, Vanessa M McDonald, Peter G Gibson
BACKGROUND: Exacerbations of asthma and COPD are a major cause of morbidity and mortality and are responsible for significant health care costs. This study further investigates interleukin (IL)-1 pathway activation and its relationship with exacerbations of asthma and COPD. METHODS: In this prospective cohort study, 95 participants with stable asthma (n=35) or COPD (n=60) were recruited and exacerbations recorded over the following 12 months. Gene expressions of IL-1 pathway biomarkers, including the IL-1 receptors (IL1R1, IL1R2, and IL1RN), and signaling molecules (IRAK2, IRAK3, and PELI1), were measured in sputum using real-time quantitative polymerase chain reaction...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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