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Asthma biomarker

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https://www.readbyqxmd.com/read/28420867/interaction-effects-of-polyfluoroalkyl-substances-and-sex-steroid-hormones-on-asthma-among-children
#1
Yang Zhou, Li-Wen Hu, Zhengmin Min Qian, Sarah Dee Geiger, Katelyn L Parrish, Shyamali C Dharmage, Brittany Campbell, Marjut Roponen, Pasi Jalava, Maija-Riitta Hirvonen, Joachim Heinrich, Xiao-Wen Zeng, Bo-Yi Yang, Xiao-Di Qin, Yungling Leo Lee, Guang-Hui Dong
To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009-2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28412250/mucosal-lining-fluid-biomarkers-in-asthma-basis-for-rational-use-of-new-targeted-therapies
#2
Rudolf Valenta
No abstract text is available yet for this article.
April 11, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28410870/interleukin-33-in-children-with-asthma-a-systematic-review-and-meta-analysis
#3
Y Wang, L Wang, S Hua
BACKGROUND: Previous studies have shown that serum interleukin 33 serving as an "alarmin" is increased in children with asthma. The objective of this study was to assess the validity of serum IL33 test for early diagnosis of childhood asthma. METHODS: A literature search was performed in June 2016 using PubMed, Embase, the Cochrane Library and other Chinese Medical Databases to identify studies. The search terms used were "cytokine", "interleukin-33", "asthma" and "children"...
April 11, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28408397/the-il-31-il-31-receptor-axis-general-features-and-role-in-tumor-microenvironment
#4
REVIEW
Elisa Ferretti, Anna Corcione, Vito Pistoia
IL-31 is a recently identified cytokine with a well-defined role in the pathogenesis of pruritus. IL-31, whose production is induced by IL-4 and IL-33, binds a heterodimeric receptor (R) composed of the exclusive IL-31RA chain and the shared oncostatin M R. Signaling through the IL-31R involves the MAPK, PI3K/AKT and Jak/STAT pathways. Different variants and isoforms of IL-31RA with different signaling activities have been identified. IL-31 is produced predominantly by circulating Th2 lymphocytes and skin-homing CLA(+)CD45RO(+) T cells...
April 13, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28400707/sani-severe-asthma-network-in-italy-a-way-forward-to-monitor-severe-asthma
#5
EDITORIAL
G Senna, M Guerriero, P L Paggiaro, F Blasi, M Caminati, E Heffler, M Latorre, G W Canonica
Even if severe asthma (SA) accounts for 5-10% of all cases of the disease, it is currently a crucial unmet need, owing its difficult clinical management and its high social costs. For this reason several networks, focused on SA have been organized in some countries, in order to select these patients, to recognize their clinical features, to evaluate their adherence, to classify their biological/clinical phenotypes, to identify their eligibility to the new biologic therapies and to quantify the costs of the disease...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28398635/serum-periostin-relates-to-type-2-inflammation-and-lung-function-in-asthma-data-from-the-large-population-based-cohort-swedish-ga-2-len
#6
Anna James, Christer Janson, Andrei Malinovschi, Cecile Holweg, Kjell Alving, Junya Ono, Shoichiro Ohta, Alexandra Ek, Roelinde Middelveld, Barbro Dahlén, Bertil Forsberg, Kenji Izuhara, Sven-Erik Dahlén
BACKGROUND: Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type-2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear. AIM: To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics...
April 11, 2017: Allergy
https://www.readbyqxmd.com/read/28391180/classifying-oxidative-stress-by-f2-isoprostane-levels-across-human-diseases-a-meta-analysis
#7
Thomas J van 't Erve, Maria B Kadiiska, Stephanie J London, Ronald P Mason
The notion that oxidative stress plays a role in virtually every human disease and environmental exposure has become ingrained in everyday knowledge. However, mounting evidence regarding the lack of specificity of biomarkers traditionally used as indicators of oxidative stress in human disease and exposures now necessitates re-evaluation. To prioritize these re-evaluations, published literature was comprehensively analyzed in a meta-analysis to quantitatively classify the levels of systemic oxidative damage across human disease and in response to environmental exposures...
March 28, 2017: Redox Biology
https://www.readbyqxmd.com/read/28390585/biomarkers-of-oxidative-stress-and-antioxidants-in-severe-asthma-a-prospective-case-control-study
#8
Abigail Bishopp, Ramamurthy Sathyamurthy, Sarah Manney, Craig Webbster, Mamidipudi Thirumala Krishna, Adel H Mansur
BACKGROUND: Bronchial airway inflammation is the hallmark of asthma, which may be driven by an imbalance between oxidative stress and antioxidant defenses. Antioxidants deficiency may play a role, but this has remained unconfirmed. OBJECTIVE: To evaluate the oxidative stress burden and antioxidants defenses in patients with increasing asthma severity. METHODS: This prospective case-control study compared fractional exhaled nitric oxide (FeNO), exhaled breath condensate nitrite/nitrate (EBC-NOx), spirometry, and serum vitamins and trace elements among patients with and without asthma...
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28382281/predictive-and-prognostic-biomarkers-of-respiratory-diseases-due-to-particulate-matter-exposure
#9
REVIEW
Hyo Jeong Kim, Min Gi Choi, Moo Kyun Park, Young Rok Seo
Air pollution is getting severe and concerns about its toxicity effects on airway and lung disease are also increasing. Particulate matter (PM) is major component of air pollutant. It causes respiratory diseases, such as asthma, chronic obstructive pulmonary disease, lung cancer, and so on. PM particles enter the airway and lung by inhalation, causing damages to them. Especially, PM2.5 can penetrate into the alveolus and pass to the systemic circulation. It can affect the cardiopulmonary system and cause cardiopulmonary disorders...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28381320/allergen-specific-immunoglobulin-e-and-allergic-rhinitis-severity
#10
Angelo G Corsico, Mara De Amici, Vanessa Ronzoni, Vania Giunta, Maria Chiara Mennitti, Arianna Viscardi, Gian Luigi Marseglia, Giorgio Ciprandi
BACKGROUND: Allergic rhinitis (AR) is a common disorder. The diagnosis is based on the concordance between allergy sensitization and history. Serum allergen specific immunoglobulin E (sIgE) assessment allows characterization of the relevant sensitizing allergens. Presently, Allergic Rhinitis and its Impact on Asthma (ARIA) classification subdivides AR based on symptoms severity and duration. However, the relationship between sIgE levels and symptom severity is still a matter of debate...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28366480/biologic-and-new-therapies-in-asthma
#11
REVIEW
Farnaz Tabatabaian, Dennis K Ledford, Thomas B Casale
Several biologics are currently FDA approved for asthma that target Th2 high patients. Unfortunately, 50% of patients with severe asthma do not fit this phenotype of disease and have fewer effective therapeutic options. In the clinical setting, total IgE, FeNO and peripheral blood eosinophils are important tools in defining Th2 high patients with asthma. However, precise biomarkers to predict better response to one specific Th2 high asthma therapy versus another is lacking. It is important to recognize that none of the current medications targeting the Th2 pathway induces persistent immunomodulation or remission...
May 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/28355256/the-usefulness-of-monomeric-periostin-as-a-biomarker-for-idiopathic-pulmonary-fibrosis
#12
Shoichiro Ohta, Masaki Okamoto, Kiminori Fujimoto, Noriho Sakamoto, Koichiro Takahashi, Hiroshi Yamamoto, Hisako Kushima, Hiroshi Ishii, Keiichi Akasaka, Junya Ono, Ayami Kamei, Yoshinori Azuma, Hisako Matsumoto, Yukie Yamaguchi, Michiko Aihara, Takeshi Johkoh, Atsushi Kawaguchi, Masao Ichiki, Hironori Sagara, Jun-Ichi Kadota, Masayuki Hanaoka, Shin-Ichiro Hayashi, Shigeru Kohno, Tomoaki Hoshino, Kenji Izuhara
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was to use monomeric periostin in a multicenter study to evaluate its efficacy in diagnosing IPF and predicting its progression. To do so, we developed a new periostin kit to detect only monomeric periostin. The subjects consisted of 60 IPF patients in a multicenter cohort study...
2017: PloS One
https://www.readbyqxmd.com/read/28353215/severe-asthma-in-children
#13
REVIEW
Bradley E Chipps, Neil G Parikh, Sheena K Maharaj
PURPOSE OF REVIEW: The aim of this study is to characterize, diagnose, evaluate, and treat severe childhood asthma. RECENT FINDINGS: Understanding the occurrence of the physiologic and clinical presentations of childhood severe asthma, the treatment and response may be predicted by biomarkers, but the patient's response is highly variable. The onset of severe asthma occurs early and is primarily predicted by severity of viral infection and coexistence of the atopic state...
April 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28350095/clinical-significance-of-scd163-and-its-possible-role-in-asthma-review
#14
Yue Zhi, Peng Gao, Xiuqin Xin, Wei Li, Lei Ji, Lin Zhang, Xueyang Zhang, Jie Zhang
Macrophages exert important functions in the balance and efficiency of immune responses, and participate in innate and adaptive immunity. The proinflammatory actions of macrophages are implicated in autoimmune diseases. Unlike classically activated M1 macrophages, the alternatively activated cluster of differentiation (CD)163+ and CD206+ M2 macrophages are involved in tissue repair and wound healing, and use oxidative metabolism to support their long‑term functions. CD163 is a member of the scavenger receptor superfamily, categorized into class B, and its soluble(s) form, sCD163, is a marker of activated M2 macrophages...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28347164/inflammatory-biomarkers-for-asthma-endotyping-and-consequent-personalized-therapy
#15
Giorgio Ciprandi, Maria Angela Tosca, Michela Silvestri, Fabio Luigi Massimo Ricciardolo
We argue that asthma be considered a syndrome caused by multiple inflammatory pathogenic processes. Bronchial hyperresponsiveness, reversible airflow limitation, and chronic airway inflammation characterize asthma pathophysiology. Personalized Medicine, i.e. a tailored management approach, is appropriate for asthma management and is based on the identification of discrete phenotypes and endotypes. Biomarkers can help define phenotypes and endotypes. Several biomarkers have been described in asthma, but most of them are not commonly available or still need external validation...
April 11, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28344579/reslizumab-and-eosinophilic-asthma-one-step-closer-to-precision-medicine
#16
REVIEW
Gilda Varricchi, Gianenrico Senna, Stefania Loffredo, Diego Bagnasco, Matteo Ferrando, Giorgio Walter Canonica
Human eosinophils represent approximately 1% of peripheral blood leukocytes. However, these cells have the propensity to leave the blood stream and migrate into inflamed tissues. Eosinophilic inflammation is present in a significant proportion of patients with severe asthma. Asthma is a chronic inflammatory disorder that affects more than 315 million people worldwide, with 10% having severe uncontrolled disease. Although the majority of patients can be efficiently treated, severe asthmatics continue to be uncontrolled and are at risk of exacerbations and even death...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28342914/blood-eosinophils-predict-therapeutic-effects-of-a-gata3-specific-dnazyme-in-asthma-patients
#17
Norbert Krug, Jens M Hohlfeld, Roland Buhl, Jonas Renz, Holger Garn, Harald Renz
The effect of the GATA3-mRNA-specific DNAzyme SB010 treatment on EAR and LAR responses continuously increased with higher relative levels of blood eosinophils making them a suitable biomarker to stratify asthma patients for inhaled SB010 treatment.
March 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28341820/il-23-gene-and-protein-expression-in-childhood-asthma
#18
Soheila Alyasin, Reza Amin, Ali Fazel, Mohammad Hossein Karimi, Seyed Hesamedin Nabavizadeh, Hossein Esmaeilzadeh, Maryam Babaei
BACKGROUND: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adult allergic asthma has been studied. OBJECTIVE: To explore IL-23 serum levels and its expression in persistent asthma compared with healthy children younger than five years old...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28332366/soluble-cd93-in-serum-as-a-marker-of-allergic-inflammation
#19
Hye Jung Park, Heejae Han, Sang Chul Lee, Young Woong Son, Da Woon Sim, Kyung Hee Park, Yoon Hee Park, Kyoung Yong Jeong, Jung Won Park, Jae Hyun Lee
PURPOSE: CD93 is receiving renewed attention as a biomarker of inflammation. We aimed to evaluate the potential for serum sCD93 to serve as a novel biomarker for allergic inflammation. MATERIALS AND METHODS: We enrolled 348 subjects with an allergic disease [allergic rhinitis (AR), chronic spontaneous urticaria (CSU), or bronchial asthma (BA)], including 14 steroid-naïve BA patients who were serially followed-up. RESULTS: The serum sCD93 levels (ng/mL) in patients with exacerbated AR (mean±standard deviation, 153...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28320793/rct-of-the-effect-of-berryfruit-polyphenolic-cultivar-extract-in-mild-steroid-naive-asthma-a-cross-over-placebo-controlled-study
#20
Sharon Power, Mathew Williams, Alex Semprini, Claire Munro, Rachel Caswell-Smith, Janine Pilcher, Mark Holliday, James Fingleton, Jacquie Harper, Roger Hurst, Mark Weatherall, Richard Beasley, Irene Braithwaite
OBJECTIVE: There is preclinical evidence that consumption of berryfruit extract may reduce chronic airways inflammation and modify airway remodelling in allergen-induced models of lung inflammation. We investigated the effect of berryfruit extract on the fractional expired nitric oxide (FeNO), a biomarker of eosinophilic airways inflammation, in adults with steroid-naïve asthma. DESIGN: Randomised placebo-controlled cross-over double-blind trial. SETTING: Single-centre community-based trial...
March 20, 2017: BMJ Open
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