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Candida auris

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https://www.readbyqxmd.com/read/29142078/candida-auris-a-review-of-the-literature
#1
REVIEW
Anna Jeffery-Smith, Surabhi K Taori, Silke Schelenz, Katie Jeffery, Elizabeth M Johnson, Andrew Borman, Rohini Manuel, Colin S Brown
The emerging pathogen Candida auris has been associated with nosocomial outbreaks on five continents. Genetic analysis indicates the simultaneous emergence of separate clades of this organism in different geographical locations. Invasive infection and colonization have been detected predominantly in patients in high-dependency settings and have garnered attention due to variable antifungal resistance profiles and transmission within units instituting a range of infection prevention and control measures. Issues with the identification of C...
January 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29122404/are-we-ready-for-the-global-emergence-of-multidrug-resistant-candida-auris-in-taiwan
#2
REVIEW
Po-Liang Lu, Wei-Lun Liu, Hsiu-Jung Lo, Fu-Der Wang, Wen-Chien Ko, Po-Ren Hsueh, Mao-Wang Ho, Chun-Eng Liu, Yen-Hsu Chen, Yee-Chun Chen, Yin-Ching Chuang, Shan-Chwen Chang
Candida auris is a recently identified multi-resistant Candida species, first reported in Japan in 2009, and poses a serious global health threat. Lack of awareness of this new Candida species and difficulties with laboratory identification have impacted significantly on outbreak detection and management, and compromised patient outcome. Accordingly, there is an urgent need to raise awareness of healthcare personnel to this emerging pathogen and determine its prevalence, impact, and challenges to the Taiwan healthcare system...
November 6, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29110544/containment-strategies-to-address-the-expanding-threat-of-multidrug-resistant-candida-auris
#3
Matthew W McCarthy, Thomas J Walsh
Candida auris is an emerging multidrug resistant human yeast pathogen associated with nosocomial transmission and high mortality. The organism can be a challenge to diagnose, may be even more difficult to treat, and continues to pose an expanding threat to patients. Areas covered: Our medical center and others in the surrounding area have seen a concerning rise in confirmed cases of C. auris infection and substantial resources have been dedicated to containment measures. We draw on our in vitro and in vivo work with this organism to examine the most effective ways to curb the current outbreak...
November 7, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29095200/emerging-multidrug-resistant-candida-species
#4
Arnaldo L Colombo, João N de Almeida Júnior, Jesus Guinea
PURPOSE OF REVIEW: To describe the epidemiology, strategies for early detection, and clinical management of infections caused by the most commonly found multidrug-resistant (MDR) Candida spp. RECENT FINDINGS: Increasing numbers of reports describing invasive infections by MDR Candida auris and Candida glabrata has been reported in medical centers worldwide. SUMMARY: We checked all papers published along the last 10 years describing epidemiological, diagnostic, and clinical aspects of infections by MDR Candida spp...
December 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29038271/evaluation-of-antifungal-efficacy-of-three-new-cyclic-lipopeptides-of-the-class-bacillomycin-from-bacillus-subtilis-rlid-12-1
#5
Ramya R, Manjari Shrivastava, Namitha N N, Ram Lal Thakur, Arunaloke Chakrabarti, Utpal Roy
New lipopeptide homologues (AF3, AF4 and AF5) with antifungal activities against Candida and Cryptococcus spp. were purified from the cell free supernatant of Bacillus subtilis RLID 12.1. The lipopeptides AF3, AF4 and AF5 were identified with the same peptide sequence Asn-Pro-Tyr-Asn-Gln-Thr-Ser with variations in the fatty acid branching type and chain length (anteiso-C17, iso-C17 and iso-C18 respectively). Comparing the three homologues for minimum inhibitory concentrations (MIC) against 81 Candida (64 no...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29020224/approach-to-the-investigation-and-management-of-patients-with-candida-auris-an-emerging-multidrug-resistant-yeast
#6
Sharon Tsay, Alexander Kallen, Brendan R Jackson, Tom M Chiller, Snigdha Vallabhaneni
Candida auris is an emerging, multidrug-resistant yeast that can spread in healthcare settings. It can cause invasive infections with high mortality and is difficult to identify using traditional yeast identification methods. C. auris has been reported in over a dozen countries, and as of July 2017, 99 clinical cases have been reported in the United States;.C. auris can colonize skin and persist in the healthcare environment, allowing for transmission between patients. Prompt investigation and aggressive interventions, including notification of public health agencies, implementation of contact precautions, thorough environmental cleaning and disinfection, infection control assessments, contact tracing and screening contacts to assess for colonization, and retrospective review of microbiology records and prospective surveillance for cases at laboratories are all needed to limit the spread of C...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28945325/isolation-of-candida-auris-from-nine-patients-in-central-america-importance-of-accurate-diagnosis-and-susceptibility-testing
#7
Ana B Araúz, Diego H Caceres, Erika Santiago, Paige Armstrong, Susan Arosemena, Carolina Ramos, Andres Espinosa-Bode, Jovanna Borace, Lizbeth Hayer, Israel Cedeño, Brendan R Jackson, Nestor Sosa, Elizabeth L Berkow, Shawn R Lockhart, Amalia Rodriguez-French, Tom Chiller
Candida auris is an emerging multidrug-resistant (MDR) fungus associated with invasive infections and high mortality. This report describes nine patients from whom C. auris was isolated at a hospital in Panama City, Panama, the first such cases in Central America, and highlights the challenges of accurate identification and methods for susceptibility testing. This article is protected by copyright. All rights reserved.
September 25, 2017: Mycoses
https://www.readbyqxmd.com/read/28939316/controlling-a-possible-outbreak-of-candida-auris-infection-lessons-learnt-from-multiple-interventions
#8
M Biswal, S M Rudramurthy, N Jain, A S Shamanth, D Sharma, K Jain, L N Yaddanapudi, A Chakrabarti
BACKGROUND: Multidrug-resistant Candida auris infection has been reported from five continents in recent years. The prevalence of C. auris invasive infection has been estimated at 5.3% for intensive-care-acquired candidaemia in India. The transmission of the organism between the patients and from environment to patients is rapid. AIM: To understand the intra-hospital dynamics of C. auris transmission and to determine the possible interventions to prevent its spread...
September 19, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28911043/multidrug-resistant-candida-epidemiology-molecular-mechanisms-and-treatment
#9
REVIEW
Maiken Cavling Arendrup, Thomas F Patterson
Invasive Candida infections remain an important cause of morbidity and mortality, especially in hospitalized and immunocompromised or critically ill patients. A limited number of antifungal agents from only a few drug classes are available to treat patients with these serious infections. Resistance can be either intrinsic or acquired. Resistance mechanisms are not exchanged between Candida; thus, acquired resistance either emerges in response to an antifungal selection pressure in the individual patient or, more rarely, occur due to horizontal transmission of resistant strains between patients...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28904185/thinking-beyond-the-common-candida-species-need-for-speciation-of-candida-due-to-the-emergence-of-multidrug-resistant-candida-auris
#10
Shawn R Lockhart, Brendan R Jackson, Snigdha Vallabhaneni, Luis Ostrosky-Zeichner, Peter G Pappas, Tom Chiller
Candida species are one of the leading causes of nosocomial infections. Because much of the treatment for Candida infections is empiric, some institutions do not identify Candida to species. With the worldwide emergence of the multidrug resistant species Candida auris, identification of Candida to species level has new clinical relevance. Species should be identified for invasive candidiasis isolates, and speciation can be considered for selected non-invasive isolates to improve detection of C. auris.
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28888662/candida-auris-an-emerging-multidrug-resistant-pathogen
#11
David Sears, Brian S Schwartz
Candida aurisis an emerging multidrug-resistant pathogen that can be difficult to identify using traditional biochemical methods. C. auris is capable of causing invasive fungal infections, particularly among hospitalized patients with significant medical comorbidities. Echinocandins are the empiric drugs of choice for C. auris, although not all isolates are susceptible and resistance may develop on therapy. Nosocomial C. auris outbreaks have been reported in a number of countries and aggressive infection control measures are paramount to stopping transmission...
October 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28872735/in-vitro-efficacy-of-disinfectants-utilised-for-skin-decolonisation-and-environmental-decontamination-during-a-hospital-outbreak-with-candida-auris
#12
Alireza Abdolrasouli, Darius Armstrong-James, Lisa Ryan, Silke Schelenz
Candida auris has caused nosocomial infections and transmissions within hospital settings. As little is known about the efficacy of skin and environmental decontamination products to kill C. auris, this study investigated the in vitro activity of chlorine, chlorhexidine, iodine povidone and vaporised hydrogen peroxide products against C. auris. H2 O2 vapour showed 96.6%-100% effective killing of C. auris. All isolates were inhibited by chlorhexidine gluconate concentrations at 0.125%-1.5% and for iodinated povidone at 0...
September 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28865738/yeasticidal-activity-of-chemical-disinfectants-and-antiseptics-against-candida-auris
#13
G Moore, S Schelenz, A M Borman, E M Johnson, C S Brown
Candida auris appears to be transmitted readily between patients, yet information regarding the efficacy of environmental disinfection and skin decolonization is lacking. A quantitative suspension test (EN 13624:2013) was used to evaluate the yeasticidal activity of different chemical disinfectants and antiseptics against C. auris and Candida albicans. When tested in suspension, both a chlorine-based disinfectant and iodine-based skin antiseptic were effective against C. auris, suggesting that their use could reduce environmental contamination and skin colonization, respectively, if applied appropriately...
September 1, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28814889/fluconazole-resistance-in-candida-species-a-current-perspective
#14
REVIEW
Elizabeth L Berkow, Shawn R Lockhart
Candida albicans and the emerging non-albicans Candida spp. have significant clinical relevance among many patient populations. Current treatment guidelines include fluconazole as a primary therapeutic option for the treatment of these infections, but it is only fungistatic against Candida spp. and both inherent and acquired resistance to fluconazole have been reported. Such mechanisms of resistance include increased drug efflux, alteration or increase in the drug target, and development of compensatory pathways for producing the target sterol, ergosterol...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28807392/candidemia-and-colonization-by-candida-auris-a-diagnostic-challenge
#15
Lourdes Viñuela-Sandoval, Iker Falces-Romero, Julio García-Rodríguez, José María Eiros-Bouza
No abstract text is available yet for this article.
August 11, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28793937/effectiveness-of-disinfectants-against-candida-auris-and-other-candida-species
#16
Jennifer L Cadnum, Aaron A Shaikh, Christina T Piedrahita, Thriveen Sankar, Annette L Jencson, Emily L Larkin, Mahmoud A Ghannoum, Curtis J Donskey
Contaminated surfaces are a suspected source for dissemination of the globally emerging pathogen Candida auris. In laboratory testing, sporicidal and improved hydrogen peroxide disinfectants were highly effective against C. auris, C. glabrata, and C. albicans. The widely used quaternary ammonium disinfectants exhibited relatively poor activity against all of the Candida species. Infect Control Hosp Epidemiol 2017;38:1240-1243.
October 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28783385/candida-auris-a-worrisome-globally-emerging-pathogen
#17
Bhagyashri D Navalkele, Sanjay Revankar, Pranatharthi Chandrasekar
Candida auris is a recently discovered, rapidly emerging fungal pathogen. Infections due to C. auris are hospital-acquired, multidrug resistant and associated with high mortality. Areas covered: This review highlights epidemiology, pathogenesis, microbiological characteristics, clinical presentation, diagnostic challenges and treatment options of C. auris infections. Infection prevention measures to prevent spread of C. auris and special measures during an outbreak situation have also been reviewed. Expert commentary: Rapid emergence of hospital onset C...
August 14, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28774698/the-global-problem-of-antifungal-resistance-prevalence-mechanisms-and-management
#18
REVIEW
David S Perlin, Riina Rautemaa-Richardson, Ana Alastruey-Izquierdo
All serious fungal infections need appropriate antifungal therapy for successful patient outcome. Only a few classes of antifungal drugs are available, so the emergence of resistance to single drug classes and now multidrug resistance greatly hampers patient management. Azole resistance among Candida and Aspergillus species is one of the greatest challenges to clinical success, followed by echinocandin and multidrug resistance among some Candida species, especially Candida glabrata. The spread of agriculturally derived azole-resistant Aspergillus fumigatus and emerging threats such as multidrug resistant Candida auris are also alarming...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28747370/survival-persistence-and-isolation-of-the-emerging-multidrug-resistant-pathogenic-yeast-candida-auris-on-a-plastic-health-care-surface
#19
Rory M Welsh, Meghan L Bentz, Alicia Shams, Hollis Houston, Amanda Lyons, Laura J Rose, Anastasia P Litvintseva
The emerging multidrug-resistant pathogenic yeast Candida auris represents a serious threat to global health. Unlike most other Candida species, this organism appears to be commonly transmitted within health care facilities and causes health care-associated outbreaks. To better understand the epidemiology of this emerging pathogen, we investigated the ability of C. auris to persist on plastic surfaces common in health care settings compared with that of Candida parapsilosis, a species known to colonize the skin and plastics...
October 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28693657/environmental-surfaces-in-healthcare-facilities-are-a-potential-source-for-transmission-of-candida-auris-and-other-candida-species
#20
Christina T Piedrahita, Jennifer L Cadnum, Annette L Jencson, Aaron A Shaikh, Mahmoud A Ghannoum, Curtis J Donskey
Contaminated surfaces have been implicated as a potential route for dissemination of the emerging multidrug-resistant fungal pathogen Candida auris. In laboratory testing, C. auris and other Candida species persisted for 7 days on moist or dry surfaces. Candida species were recovered frequently from the hospital environment, particularly from moist surfaces. Infect Control Hosp Epidemiol 2017;1-3.
July 11, 2017: Infection Control and Hospital Epidemiology
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