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Candida auris

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https://www.readbyqxmd.com/read/28693657/environmental-surfaces-in-healthcare-facilities-are-a-potential-source-for-transmission-of-candida-auris-and-other-candida-species
#1
Christina T Piedrahita, Jennifer L Cadnum, Annette L Jencson, Aaron A Shaikh, Mahmoud A Ghannoum, Curtis J Donskey
Contaminated surfaces have been implicated as a potential route for dissemination of the emerging multidrug-resistant fungal pathogen Candida auris. In laboratory testing, C. auris and other Candida species persisted for 7 days on moist or dry surfaces. Candida species were recovered frequently from the hospital environment, particularly from moist surfaces. Infect Control Hosp Epidemiol 2017;1-3.
July 11, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28685887/the-first-cases-of-candida-auris-candidaemia-in-oman
#2
Jalila Mohsin, Ferry Hagen, Zainab A M Al-Balushi, G Sybren de Hoog, Anuradha Chowdhary, Jacques F Meis, Abdullah M S Al-Hatmi
Candida auris has been recognised as a problematic healthcare-associated emerging yeast which is often misidentified as Candida haemulonii by commercial systems. Correct early identification of C. auris is important for appropriate antifungal treatment and implementing effective infection control measures. Here we report emergence of the first C. auris cases in Oman, initially misidentified as C. haemulonii.
July 7, 2017: Mycoses
https://www.readbyqxmd.com/read/28669831/epidemiology-of-antifungal-resistance-in-human-pathogenic-yeasts-current-viewpoint-and-practical-recommendations-for-management
#3
Dimitrios Farmakiotis, Dimitrios P Kontoyiannis
In this review, we describe the epidemiology and clinical significance of resistance in Candida spp. and other non-Cryptococcus yeasts. The rise in echinocandin resistance, azole resistance and cross-resistance to ≥2 antifungal classes (multi-drug resistance: MDR) has been a worrisome trend, mainly in US large tertiary and oncology centers, particularly as it relates to C. glabrata. C. kefyr is also a concern, as it can be resistant to echinocandins and polyenes, especially in patients with hematologic malignancies...
June 29, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28657070/use-of-rna-protein-complexes-for-genome-editing-in-non-albicans-candida-species
#4
Nora Grahl, Elora G Demers, Alex W Crocker, Deborah A Hogan
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 genome modification systems have greatly facilitated the genetic analysis of fungal pathogens. In CRISPR-Cas9 genome editing methods designed for use in Candida albicans, DNAs that encode the necessary components are expressed in the target cells. Unfortunately, expression constructs that work efficiently in C. albicans are not necessarily expressed well in other pathogenic species within the genus Candida or the related genus Clavispora...
May 2017: MSphere
https://www.readbyqxmd.com/read/28652784/current-perspective-on-emergence-diagnosis-and-drug-resistance-in-candida-auris
#5
REVIEW
Smita Sarma, Shalini Upadhyay
Candida auris is an emerging fungus that presents a serious threat to global health. The organism is difficult to identify using conventional biochemical methods. C. auris has also attracted attention because of its reduced susceptibility to azoles, polyenes, and echinocandins, with a few strains even resistant to all three classes of antifungals. In this review paper we discuss the trends in emergence of C. auris in different parts of the world, associated risk factors, drug resistance, and diagnostic challenges...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28632836/-multidrug-resistant-candida-auris-new-kid-on-the-block-in-hospital-associated-infections
#6
Cecilia Tapia, Christian Batarce
No abstract text is available yet for this article.
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28584152/pharmacodynamic-optimization-for-treatment-of-invasive-candida-auris-infection
#7
Alexander J Lepak, Miao Zhao, Elizabeth L Berkow, Shawn R Lockhart, David R Andes
Candida auris is an emerging, multidrug-resistant threat. The pharmacodynamics of three antifungal classes against nine C. auris strains was explored using a murine invasive candidiasis model. The total drug median PD target associated with net stasis was a fluconazole AUC/MIC of 26, amphotericin B Cmax/MIC of 0.9, and micafungin AUC/MIC of 54. The micafungin PD targets for C. auris were ≥20-fold lower than other Candida species in this animal model. Clinically relevant micafungin exposures produced the most killing among the three classes...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28542486/candida-auris-a-rapidly-emerging-cause-of-hospital-acquired-multidrug-resistant-fungal-infections-globally
#8
Anuradha Chowdhary, Cheshta Sharma, Jacques F Meis
No abstract text is available yet for this article.
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28539346/rapid-and-accurate-molecular-identification-of-the-emerging-multidrug-resistant-pathogen-candida-auris
#9
Milena Kordalewska, Yanan Zhao, Shawn R Lockhart, Anuradha Chowdhary, Indira Berrio, David S Perlin
Candida auris is an emerging multidrug resistant fungal pathogen causing nosocomial and invasive infections associated with high mortality. C. auris is commonly misidentified as several different yeast species by commercially available phenotypic identification platforms. Thus, there is an urgent need for a reliable diagnostic method. In this paper we present fast, robust, easy to perform and interpret PCR and real-time PCR assays to identify C. auris and related species: Candida duobushaemulonii, Candida haemulonii, and Candida lusitaniae Targeting rDNA region nucleotide sequences, primers specific for C...
May 24, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28520901/donor-derived-transmission-of-candida-auris-during-lung-transplantation
#10
Marwan M Azar, Sarah E Turbett, Jay A Fishman, Virginia M Pierce
Candida auris is an emerging, often multidrug resistant pathogen with important public health implications. Infections are associated with high mortality, and prevention of transmission requires stringent infection control measures, making C. auris a potential barrier to transplantation. We describe the first donor-derived C. auris transmission in a lung transplant recipient.
May 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28520710/notes-from-the-field-ongoing-transmission-of-candida-auris-in-health-care-facilities-united-states-june-2016-may-2017
#11
Sharon Tsay, Rory M Welsh, Eleanor H Adams, Nancy A Chow, Lalitha Gade, Elizabeth L Berkow, Eugenie Poirot, Emily Lutterloh, Monica Quinn, Sudha Chaturvedi, Janna Kerins, Stephanie R Black, Sarah K Kemble, Patricia M Barrett, Kerri Barton, D J Shannon, Kristy Bradley, Shawn R Lockhart, Anastasia P Litvintseva, Heather Moulton-Meissner, Alicia Shugart, Alex Kallen, Snigdha Vallabhaneni, Tom M Chiller, Brendan R Jackson
No abstract text is available yet for this article.
May 19, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28483955/in-vitro-activity-of-a-novel-glucan-synthase-inhibitor-scy-078-against-clinical-isolates-of-candida-auris
#12
LETTER
Elizabeth L Berkow, David Angulo, Shawn R Lockhart
No abstract text is available yet for this article.
July 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28480775/drug-development-challenges-and-strategies-to-address-emerging-and-resistant-fungal-pathogens
#13
Matthew W McCarthy, Thomas J Walsh
Invasive fungal infections represent an expanding threat to public health. The recent emergence of Candida auris, which is often resistant to existing antifungal agents and is associated with a high mortality rate, underscores the urgent need for novel drug development strategies. Areas covered: In this paper, we examine both challenges and opportunities associated with antifungal drug development and explore potential avenues to accelerate the development pipeline, including data sharing, surrogate endpoints, and the role of historical controls in clinical trials...
May 15, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28416539/comparison-of-eucast-and-clsi-reference-microdilution-mics-of-eight-antifungal-compounds-for-candida-auris-and-associated-tentative-epidemiological-cutoff-values
#14
M C Arendrup, Anupam Prakash, Joseph Meletiadis, Cheshta Sharma, Anuradha Chowdhary
Candida auris is an emerging multidrug-resistant yeast. So far, all but two susceptibility testing studies have examined ≤50 isolates, mostly with the CLSI method. We investigated CLSI and EUCAST MICs for 123 C. auris isolates and eight antifungals and evaluated various methods for epidemiological cutoff (ECOFF) determinations. MICs (in milligrams per liter) were determined using CLSI method M27-A3, and the EUCAST E.Def 7.3. ANOVA analysis of variance with Bonferroni's multiple-comparison test and Pearson analysis were used on log2 MICs (significance at P values of <0...
June 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28392225/simple-low-cost-differentiation-of-candida-auris-from-candida-haemulonii-complex-using-chromagar-candida-medium-supplemented-with-pal-s-medium
#15
Anil Kumar, Arun Sachu, Karthika Mohan, Vivek Vinod, Kavitha Dinesh, Shamsul Karim
BACKGROUND: Candida auris is unique due to its multidrug resistance and misidentification as Candida haemulonii by commercial systems. Its correct identification is important to avoid inappropriate treatments. AIMS: To develop a cheap method for differentiating C. auris from isolates identified as C. haemulonii by VITEK2. METHODS: Fifteen C. auris isolates, six isolates each of C. haemulonii and Candida duobushaemulonii, and one isolate of Candida haemulonii var...
April 6, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28378904/otomastoiditis-caused-by-candida-auris-case-report-and-literature-review
#16
REVIEW
Hyoung Il Choi, Jin An, Jae Joon Hwang, Soo-Youn Moon, Jun Seong Son
Fungal otomastoiditis is a rare disease, but can be fatal for immunocompromised patients. Recently, there have been increasing cases of otologic infection caused by Candida auris. Candida auris can be easily misdiagnosed for other species and treatment is difficult due to multidrug resistance. Clinician should be aware of this rare pathogen, and it should be treated with appropriate antifungal agent with surgical debridement.
April 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28333744/clinical-alert-candida-auris
#17
Betsy Todd
A new pathogen is making its presence known.
April 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28333181/candida-auris-candidaemia-in-indian-icus-analysis-of-risk-factors
#18
Shivaprakash M Rudramurthy, Arunaloke Chakrabarti, Raees A Paul, Prashant Sood, Harsimran Kaur, Malini R Capoor, Anupma J Kindo, Rungmei S K Marak, Anita Arora, Raman Sardana, Shukla Das, Deepinder Chhina, Atul Patel, Immaculata Xess, Bansidhar Tarai, Pankaj Singh, Anup Ghosh
Objectives: To identify the risk factors associated with Candida auris candidaemia, as this fungus now poses a global threat. Methods: We performed a subgroup analysis of a previously reported study of 27 Indian ICUs. The clinical data of candidaemia cases due to C. auris and other Candida species were compared to determine significant risk factors associated with C. auris infection. Results: Of the 1400 candidaemia cases reported earlier, 74 (5...
June 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28223375/the-emerging-pathogen-candida-auris-growth-phenotype-virulence-factors-activity-of-antifungals-and-effect-of-scy-078-a-novel-glucan-synthesis-inhibitor-on-growth-morphology-and-biofilm-formation
#19
Emily Larkin, Christopher Hager, Jyotsna Chandra, Pranab K Mukherjee, Mauricio Retuerto, Iman Salem, Lisa Long, Nancy Isham, Laura Kovanda, Katyna Borroto-Esoda, Steve Wring, David Angulo, Mahmoud Ghannoum
Candidaauris, a new multidrug-resistant Candida spp. which is associated with invasive infection and high rates of mortality, has recently emerged. Here, we determined the virulence factors (germination, adherence, biofilm formation, phospholipase and proteinase production) of 16 C. auris isolates and their susceptibilities to 11 drugs belonging to different antifungal classes, including a novel orally bioavailable 1,3-β-d-glucan synthesis inhibitor (SCY-078). We also examined the effect of SCY-078 on the growth, ultrastructure, and biofilm-forming abilities of C...
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28204557/isolates-of-the-emerging-pathogen-candida-auris-present-in-the-uk-have-several-geographic-origins
#20
Andrew M Borman, Adrien Szekely, Elizabeth M Johnson
No abstract text is available yet for this article.
February 16, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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