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Candida auris

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https://www.readbyqxmd.com/read/28814889/fluconazole-resistance-in-candida-species-a-current-perspective
#1
REVIEW
Elizabeth L Berkow, Shawn R Lockhart
Candida albicans and the emerging non-albicans Candida spp. have significant clinical relevance among many patient populations. Current treatment guidelines include fluconazole as a primary therapeutic option for the treatment of these infections, but it is only fungistatic against Candida spp. and both inherent and acquired resistance to fluconazole have been reported. Such mechanisms of resistance include increased drug efflux, alteration or increase in the drug target, and development of compensatory pathways for producing the target sterol, ergosterol...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28807392/candidemia-and-colonization-by-candida-auris-a-diagnostic-challenge
#2
Lourdes Viñuela-Sandoval, Iker Falces-Romero, Julio García-Rodríguez, José María Eiros-Bouza
No abstract text is available yet for this article.
August 11, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28793937/effectiveness-of-disinfectants-against-candida-auris-and-other-candida-species
#3
Jennifer L Cadnum, Aaron A Shaikh, Christina T Piedrahita, Thriveen Sankar, Annette L Jencson, Emily L Larkin, Mahmoud A Ghannoum, Curtis J Donskey
Contaminated surfaces are a suspected source for dissemination of the globally emerging pathogen Candida auris. In laboratory testing, sporicidal and improved hydrogen peroxide disinfectants were highly effective against C. auris, C. glabrata, and C. albicans. The widely used quaternary ammonium disinfectants exhibited relatively poor activity against all of the Candida species. Infect Control Hosp Epidemiol 2017;1-4.
August 10, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28783385/candida-auris-a-worrisome-globally-emerging-pathogen
#4
Bhagyashri D Navalkele, Sanjay Revankar, Pranatharthi Chandrasekar
Candida auris is a recently discovered, rapidly emerging fungal pathogen. Infections due to C. auris are hospital-acquired, multidrug resistant and associated with high mortality. Areas covered: This review highlights epidemiology, pathogenesis, microbiological characteristics, clinical presentation, diagnostic challenges and treatment options of C. auris infections. Infection prevention measures to prevent spread of C. auris and special measures during an outbreak situation have also been reviewed. Expert commentary: Rapid emergence of hospital onset C...
August 7, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28774698/the-global-problem-of-antifungal-resistance-prevalence-mechanisms-and-management
#5
REVIEW
David S Perlin, Riina Rautemaa-Richardson, Ana Alastruey-Izquierdo
All serious fungal infections need appropriate antifungal therapy for successful patient outcome. Only a few classes of antifungal drugs are available, so the emergence of resistance to single drug classes and now multidrug resistance greatly hampers patient management. Azole resistance among Candida and Aspergillus species is one of the greatest challenges to clinical success, followed by echinocandin and multidrug resistance among some Candida species, especially Candida glabrata. The spread of agriculturally derived azole-resistant Aspergillus fumigatus and emerging threats such as multidrug resistant Candida auris are also alarming...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28747370/survival-persistence-and-isolation-of-the-emerging-multidrug-resistant-pathogenic-yeast-candida-auris-on-a-plastic-healthcare-surface
#6
Rory M Welsh, Meghan L Bentz, Alicia Shams, Hollis Houston, Amanda Lyons, Laura J Rose, Anastasia P Litvintseva
The emerging multidrug-resistant pathogenic yeast Candida auris represents a serious threat to global health. Unlike most other Candida species, this organism appears to be commonly transmitted within healthcare facilities and is capable of causing healthcare-associated outbreaks. To better understand the epidemiology of this emerging pathogen we investigated the ability of C. auris to persist on plastic surfaces common in healthcare settings and compared with that of Candida parapsilosis, a species known to colonize the skin and plastics...
July 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28693657/environmental-surfaces-in-healthcare-facilities-are-a-potential-source-for-transmission-of-candida-auris-and-other-candida-species
#7
Christina T Piedrahita, Jennifer L Cadnum, Annette L Jencson, Aaron A Shaikh, Mahmoud A Ghannoum, Curtis J Donskey
Contaminated surfaces have been implicated as a potential route for dissemination of the emerging multidrug-resistant fungal pathogen Candida auris. In laboratory testing, C. auris and other Candida species persisted for 7 days on moist or dry surfaces. Candida species were recovered frequently from the hospital environment, particularly from moist surfaces. Infect Control Hosp Epidemiol 2017;1-3.
July 11, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28685887/the-first-cases-of-candida-auris-candidaemia-in-oman
#8
Jalila Mohsin, Ferry Hagen, Zainab A M Al-Balushi, G Sybren de Hoog, Anuradha Chowdhary, Jacques F Meis, Abdullah M S Al-Hatmi
Candida auris has been recognised as a problematic healthcare-associated emerging yeast which is often misidentified as Candida haemulonii by commercial systems. Correct early identification of C. auris is important for appropriate antifungal treatment and implementing effective infection control measures. Here we report emergence of the first C. auris cases in Oman, initially misidentified as C. haemulonii.
July 7, 2017: Mycoses
https://www.readbyqxmd.com/read/28669831/epidemiology-of-antifungal-resistance-in-human-pathogenic-yeasts-current-viewpoint-and-practical-recommendations-for-management
#9
Dimitrios Farmakiotis, Dimitrios P Kontoyiannis
In this review, we describe the epidemiology and clinical significance of resistance in Candida spp. and other non-Cryptococcus yeasts. The rise in echinocandin resistance, azole resistance and cross-resistance to ≥2 antifungal classes (multi-drug resistance: MDR) has been a worrisome trend, mainly in US large tertiary and oncology centers, particularly as it relates to C. glabrata. C. kefyr is also a concern, as it can be resistant to echinocandins and polyenes, especially in patients with hematologic malignancies...
June 29, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28657070/use-of-rna-protein-complexes-for-genome-editing-in-non-albicans-candida-species
#10
Nora Grahl, Elora G Demers, Alex W Crocker, Deborah A Hogan
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 genome modification systems have greatly facilitated the genetic analysis of fungal pathogens. In CRISPR-Cas9 genome editing methods designed for use in Candida albicans, DNAs that encode the necessary components are expressed in the target cells. Unfortunately, expression constructs that work efficiently in C. albicans are not necessarily expressed well in other pathogenic species within the genus Candida or the related genus Clavispora...
May 2017: MSphere
https://www.readbyqxmd.com/read/28652784/current-perspective-on-emergence-diagnosis-and-drug-resistance-in-candida-auris
#11
REVIEW
Smita Sarma, Shalini Upadhyay
Candida auris is an emerging fungus that presents a serious threat to global health. The organism is difficult to identify using conventional biochemical methods. C. auris has also attracted attention because of its reduced susceptibility to azoles, polyenes, and echinocandins, with a few strains even resistant to all three classes of antifungals. In this review paper we discuss the trends in emergence of C. auris in different parts of the world, associated risk factors, drug resistance, and diagnostic challenges...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28632836/-multidrug-resistant-candida-auris-new-kid-on-the-block-in-hospital-associated-infections
#12
COMMENT
Cecilia Tapia, Christian Batarce
No abstract text is available yet for this article.
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28584152/pharmacodynamic-optimization-for-treatment-of-invasive-candida-auris-infection
#13
Alexander J Lepak, Miao Zhao, Elizabeth L Berkow, Shawn R Lockhart, David R Andes
Candida auris is an emerging multidrug-resistant threat. The pharmacodynamics of three antifungal classes against nine C. auris strains was explored using a murine invasive candidiasis model. The total drug median pharmacodynamic (PD) target associated with net stasis was a fluconazole AUC/MIC (the area under the concentration-time curve over 24 h in the steady state divided by the MIC) of 26, an amphotericin B Cmax/MIC (maximum concentration of drug in serum divided by the MIC) of 0.9, and a micafungin AUC/MIC of 54...
August 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28542486/candida-auris-a-rapidly-emerging-cause-of-hospital-acquired-multidrug-resistant-fungal-infections-globally
#14
Anuradha Chowdhary, Cheshta Sharma, Jacques F Meis
No abstract text is available yet for this article.
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28539346/rapid-and-accurate-molecular-identification-of-the-emerging-multidrug-resistant-pathogen-candida-auris
#15
Milena Kordalewska, Yanan Zhao, Shawn R Lockhart, Anuradha Chowdhary, Indira Berrio, David S Perlin
Candida auris is an emerging multidrug-resistant fungal pathogen causing nosocomial and invasive infections associated with high mortality. C. auris is commonly misidentified as several different yeast species by commercially available phenotypic identification platforms. Thus, there is an urgent need for a reliable diagnostic method. In this paper, we present fast, robust, easy-to-perform and interpret PCR and real-time PCR assays to identify C. auris and related species: Candida duobushaemulonii, Candida haemulonii, and Candida lusitaniae Targeting rDNA region nucleotide sequences, primers specific for C...
August 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28520901/donor-derived-transmission-of-candida-auris-during-lung-transplantation
#16
Marwan M Azar, Sarah E Turbett, Jay A Fishman, Virginia M Pierce
Candida auris is an emerging, often multidrug resistant pathogen with important public health implications. Infections are associated with high mortality, and prevention of transmission requires stringent infection control measures, making C. auris a potential barrier to transplantation. We describe the first donor-derived C. auris transmission in a lung transplant recipient.
May 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28520710/notes-from-the-field-ongoing-transmission-of-candida-auris-in-health-care-facilities-united-states-june-2016-may-2017
#17
Sharon Tsay, Rory M Welsh, Eleanor H Adams, Nancy A Chow, Lalitha Gade, Elizabeth L Berkow, Eugenie Poirot, Emily Lutterloh, Monica Quinn, Sudha Chaturvedi, Janna Kerins, Stephanie R Black, Sarah K Kemble, Patricia M Barrett, Kerri Barton, D J Shannon, Kristy Bradley, Shawn R Lockhart, Anastasia P Litvintseva, Heather Moulton-Meissner, Alicia Shugart, Alex Kallen, Snigdha Vallabhaneni, Tom M Chiller, Brendan R Jackson
No abstract text is available yet for this article.
May 19, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28483955/in-vitro-activity-of-a-novel-glucan-synthase-inhibitor-scy-078-against-clinical-isolates-of-candida-auris
#18
LETTER
Elizabeth L Berkow, David Angulo, Shawn R Lockhart
No abstract text is available yet for this article.
July 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28480775/drug-development-challenges-and-strategies-to-address-emerging-and-resistant-fungal-pathogens
#19
Matthew W McCarthy, Thomas J Walsh
Invasive fungal infections represent an expanding threat to public health. The recent emergence of Candida auris, which is often resistant to existing antifungal agents and is associated with a high mortality rate, underscores the urgent need for novel drug development strategies. Areas covered: In this paper, we examine both challenges and opportunities associated with antifungal drug development and explore potential avenues to accelerate the development pipeline, including data sharing, surrogate endpoints, and the role of historical controls in clinical trials...
May 15, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28416539/comparison-of-eucast-and-clsi-reference-microdilution-mics-of-eight-antifungal-compounds-for-candida-auris-and-associated-tentative-epidemiological-cutoff-values
#20
M C Arendrup, Anupam Prakash, Joseph Meletiadis, Cheshta Sharma, Anuradha Chowdhary
Candida auris is an emerging multidrug-resistant yeast. So far, all but two susceptibility testing studies have examined ≤50 isolates, mostly with the CLSI method. We investigated CLSI and EUCAST MICs for 123 C. auris isolates and eight antifungals and evaluated various methods for epidemiological cutoff (ECOFF) determinations. MICs (in milligrams per liter) were determined using CLSI method M27-A3, and the EUCAST E.Def 7.3. ANOVA analysis of variance with Bonferroni's multiple-comparison test and Pearson analysis were used on log2 MICs (significance at P values of <0...
June 2017: Antimicrobial Agents and Chemotherapy
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