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Candida auris

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https://www.readbyqxmd.com/read/28911043/multidrug-resistant-candida-epidemiology-molecular-mechanisms-and-treatment
#1
REVIEW
Maiken Cavling Arendrup, Thomas F Patterson
Invasive Candida infections remain an important cause of morbidity and mortality, especially in hospitalized and immunocompromised or critically ill patients. A limited number of antifungal agents from only a few drug classes are available to treat patients with these serious infections. Resistance can be either intrinsic or acquired. Resistance mechanisms are not exchanged between Candida; thus, acquired resistance either emerges in response to an antifungal selection pressure in the individual patient or, more rarely, occur due to horizontal transmission of resistant strains between patients...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28904185/thinking-beyond-the-common-candida-species-need-for-speciation-of-candida-due-to-the-emergence-of-multidrug-resistant-candida-auris
#2
Shawn R Lockhart, Brendan R Jackson, Snigdha Vallabhaneni, Luis Ostrosky-Zeichner, Peter G Pappas, Tom Chiller
Candida species are one of the leading causes of nosocomial infections. Because much of the treatment for Candida infections is empiric, some institutions do not identify Candida to species. With the worldwide emergence of the multidrug resistant species Candida auris, identification of Candida to species level has new clinical relevance. Species should be identified for invasive candidiasis isolates, and speciation can be considered for selected non-invasive isolates to improve detection of C. auris.
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28888662/candida-auris-an-emerging-multidrug-resistant-pathogen
#3
David Sears, Brian S Schwartz
Candida aurisis an emerging multidrug-resistant pathogen that can be difficult to identify using traditional biochemical methods. C. auris is capable of causing invasive fungal infections, particularly among hospitalized patients with significant medical comorbidities. Echinocandins are the empiric drugs of choice for C. auris, although not all isolates are susceptible and resistance may develop on therapy. Nosocomial C. auris outbreaks have been reported in a number of countries and aggressive infection control measures are paramount to stopping transmission...
September 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28872735/in-vitro-efficacy-of-disinfectants-utilised-for-skin-decolonization-and-environmental-decontamination-during-a-hospital-outbreak-with-candida-auris
#4
A Abdolrasouli, D Armstrong-James, L Ryan, S Schelenz
Candida auris has caused nosocomial infections and transmissions within hospital settings. As little is known about the efficacy of skin and environmental decontamination products to kill C. auris this study investigated the in vitro activity of chlorine, chlorhexidine, iodine povidone and vaporized hydrogen peroxide products against C. auris. H2 O2 vapour showed 96.6-100% effective killing of C. auris. All isolates were inhibited by chlorhexidine gluconate concentrations at 0.125 to 1.5% and for iodinated povidone at 0...
September 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28865738/the-yeasticidal-activity-of-chemical-disinfectants-and-antiseptics-against-candida-auris
#5
Ginny Moore, Silke Schelenz, Andrew M Borman, Elizabeth M Johnson, Colin S Brown
Candida auris appears to be readily transmitted between patients, yet, information regarding the efficacy of environmental disinfection and skin decolonisation is lacking. A quantitative suspension test (EN 13624:2013) was used to evaluate the yeasticidal activity of different chemical disinfectants and antiseptics against C. auris and C. albicans. When tested in suspension, both a chlorine-based disinfectant and iodine-based skin antiseptic were effective against C. auris suggesting that, if applied appropriately, their use could reduce environmental contamination and skin colonisation respectively...
August 30, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28814889/fluconazole-resistance-in-candida-species-a-current-perspective
#6
REVIEW
Elizabeth L Berkow, Shawn R Lockhart
Candida albicans and the emerging non-albicans Candida spp. have significant clinical relevance among many patient populations. Current treatment guidelines include fluconazole as a primary therapeutic option for the treatment of these infections, but it is only fungistatic against Candida spp. and both inherent and acquired resistance to fluconazole have been reported. Such mechanisms of resistance include increased drug efflux, alteration or increase in the drug target, and development of compensatory pathways for producing the target sterol, ergosterol...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28807392/candidemia-and-colonization-by-candida-auris-a-diagnostic-challenge
#7
Lourdes Viñuela-Sandoval, Iker Falces-Romero, Julio García-Rodríguez, José María Eiros-Bouza
No abstract text is available yet for this article.
August 11, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28793937/effectiveness-of-disinfectants-against-candida-auris-and-other-candida-species
#8
Jennifer L Cadnum, Aaron A Shaikh, Christina T Piedrahita, Thriveen Sankar, Annette L Jencson, Emily L Larkin, Mahmoud A Ghannoum, Curtis J Donskey
Contaminated surfaces are a suspected source for dissemination of the globally emerging pathogen Candida auris. In laboratory testing, sporicidal and improved hydrogen peroxide disinfectants were highly effective against C. auris, C. glabrata, and C. albicans. The widely used quaternary ammonium disinfectants exhibited relatively poor activity against all of the Candida species. Infect Control Hosp Epidemiol 2017;1-4.
August 10, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28783385/candida-auris-a-worrisome-globally-emerging-pathogen
#9
Bhagyashri D Navalkele, Sanjay Revankar, Pranatharthi Chandrasekar
Candida auris is a recently discovered, rapidly emerging fungal pathogen. Infections due to C. auris are hospital-acquired, multidrug resistant and associated with high mortality. Areas covered: This review highlights epidemiology, pathogenesis, microbiological characteristics, clinical presentation, diagnostic challenges and treatment options of C. auris infections. Infection prevention measures to prevent spread of C. auris and special measures during an outbreak situation have also been reviewed. Expert commentary: Rapid emergence of hospital onset C...
August 14, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28774698/the-global-problem-of-antifungal-resistance-prevalence-mechanisms-and-management
#10
REVIEW
David S Perlin, Riina Rautemaa-Richardson, Ana Alastruey-Izquierdo
All serious fungal infections need appropriate antifungal therapy for successful patient outcome. Only a few classes of antifungal drugs are available, so the emergence of resistance to single drug classes and now multidrug resistance greatly hampers patient management. Azole resistance among Candida and Aspergillus species is one of the greatest challenges to clinical success, followed by echinocandin and multidrug resistance among some Candida species, especially Candida glabrata. The spread of agriculturally derived azole-resistant Aspergillus fumigatus and emerging threats such as multidrug resistant Candida auris are also alarming...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28747370/survival-persistence-and-isolation-of-the-emerging-multidrug-resistant-pathogenic-yeast-candida-auris-on-a-plastic-healthcare-surface
#11
Rory M Welsh, Meghan L Bentz, Alicia Shams, Hollis Houston, Amanda Lyons, Laura J Rose, Anastasia P Litvintseva
The emerging multidrug-resistant pathogenic yeast Candida auris represents a serious threat to global health. Unlike most other Candida species, this organism appears to be commonly transmitted within healthcare facilities and is capable of causing healthcare-associated outbreaks. To better understand the epidemiology of this emerging pathogen we investigated the ability of C. auris to persist on plastic surfaces common in healthcare settings and compared with that of Candida parapsilosis, a species known to colonize the skin and plastics...
July 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28693657/environmental-surfaces-in-healthcare-facilities-are-a-potential-source-for-transmission-of-candida-auris-and-other-candida-species
#12
Christina T Piedrahita, Jennifer L Cadnum, Annette L Jencson, Aaron A Shaikh, Mahmoud A Ghannoum, Curtis J Donskey
Contaminated surfaces have been implicated as a potential route for dissemination of the emerging multidrug-resistant fungal pathogen Candida auris. In laboratory testing, C. auris and other Candida species persisted for 7 days on moist or dry surfaces. Candida species were recovered frequently from the hospital environment, particularly from moist surfaces. Infect Control Hosp Epidemiol 2017;1-3.
July 11, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28685887/the-first-cases-of-candida-auris-candidaemia-in-oman
#13
Jalila Mohsin, Ferry Hagen, Zainab A M Al-Balushi, G Sybren de Hoog, Anuradha Chowdhary, Jacques F Meis, Abdullah M S Al-Hatmi
Candida auris has been recognised as a problematic healthcare-associated emerging yeast which is often misidentified as Candida haemulonii by commercial systems. Correct early identification of C. auris is important for appropriate antifungal treatment and implementing effective infection control measures. Here we report emergence of the first C. auris cases in Oman, initially misidentified as C. haemulonii.
September 2017: Mycoses
https://www.readbyqxmd.com/read/28669831/epidemiology-of-antifungal-resistance-in-human-pathogenic-yeasts-current-viewpoint-and-practical-recommendations-for-management
#14
Dimitrios Farmakiotis, Dimitrios P Kontoyiannis
In this review, we describe the epidemiology and clinical significance of resistance in Candida spp. and other non-Cryptococcus yeasts. The rise in echinocandin resistance, azole resistance and cross-resistance to two or more antifungal classes [multidrug resistance (MDR)] has been a worrisome trend, mainly in US large tertiary and oncology centres, particularly as it relates to Candida glabrata. Candida kefyr is also a concern as it can be resistant to echinocandins and polyenes, especially in patients with haematological malignancies...
June 29, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28657070/use-of-rna-protein-complexes-for-genome-editing-in-non-albicans-candida-species
#15
Nora Grahl, Elora G Demers, Alex W Crocker, Deborah A Hogan
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 genome modification systems have greatly facilitated the genetic analysis of fungal pathogens. In CRISPR-Cas9 genome editing methods designed for use in Candida albicans, DNAs that encode the necessary components are expressed in the target cells. Unfortunately, expression constructs that work efficiently in C. albicans are not necessarily expressed well in other pathogenic species within the genus Candida or the related genus Clavispora...
May 2017: MSphere
https://www.readbyqxmd.com/read/28652784/current-perspective-on-emergence-diagnosis-and-drug-resistance-in-candida-auris
#16
REVIEW
Smita Sarma, Shalini Upadhyay
Candida auris is an emerging fungus that presents a serious threat to global health. The organism is difficult to identify using conventional biochemical methods. C. auris has also attracted attention because of its reduced susceptibility to azoles, polyenes, and echinocandins, with a few strains even resistant to all three classes of antifungals. In this review paper we discuss the trends in emergence of C. auris in different parts of the world, associated risk factors, drug resistance, and diagnostic challenges...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28632836/-multidrug-resistant-candida-auris-new-kid-on-the-block-in-hospital-associated-infections
#17
COMMENT
Cecilia Tapia, Christian Batarce
No abstract text is available yet for this article.
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28584152/pharmacodynamic-optimization-for-treatment-of-invasive-candida-auris-infection
#18
Alexander J Lepak, Miao Zhao, Elizabeth L Berkow, Shawn R Lockhart, David R Andes
Candida auris is an emerging multidrug-resistant threat. The pharmacodynamics of three antifungal classes against nine C. auris strains was explored using a murine invasive candidiasis model. The total drug median pharmacodynamic (PD) target associated with net stasis was a fluconazole AUC/MIC (the area under the concentration-time curve over 24 h in the steady state divided by the MIC) of 26, an amphotericin B Cmax/MIC (maximum concentration of drug in serum divided by the MIC) of 0.9, and a micafungin AUC/MIC of 54...
August 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28542486/candida-auris-a-rapidly-emerging-cause-of-hospital-acquired-multidrug-resistant-fungal-infections-globally
#19
Anuradha Chowdhary, Cheshta Sharma, Jacques F Meis
No abstract text is available yet for this article.
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28539346/rapid-and-accurate-molecular-identification-of-the-emerging-multidrug-resistant-pathogen-candida-auris
#20
Milena Kordalewska, Yanan Zhao, Shawn R Lockhart, Anuradha Chowdhary, Indira Berrio, David S Perlin
Candida auris is an emerging multidrug-resistant fungal pathogen causing nosocomial and invasive infections associated with high mortality. C. auris is commonly misidentified as several different yeast species by commercially available phenotypic identification platforms. Thus, there is an urgent need for a reliable diagnostic method. In this paper, we present fast, robust, easy-to-perform and interpret PCR and real-time PCR assays to identify C. auris and related species: Candida duobushaemulonii, Candida haemulonii, and Candida lusitaniae Targeting rDNA region nucleotide sequences, primers specific for C...
August 2017: Journal of Clinical Microbiology
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