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Candida auris

Patricia Escandón, Nancy A Chow, Diego H Caceres, Lalitha Gade, Elizabeth L Berkow, Paige Armstrong, Sandra Rivera, Elizabeth Misas, Carolina Duarte, Heather Moulton-Meissner, Rory M Welsh, Claudia Parra, Luz Angela Pescador, Nohora Villalobos, Soraya Salcedo, Indira Berrio, Carmen Varón, Andrés Espinosa-Bode, Shawn R Lockhart, Brendan R Jackson, Anastasia P Litvintseva, Mauricio Beltran, Tom M Chiller
Background: Candida auris is a multidrug-resistant yeast associated with hospital outbreaks worldwide. During 2015-2016, multiple outbreaks were reported in Colombia. We aimed to understand the extent of contamination in healthcare settings and to characterize the molecular epidemiology of C. auris in Colombia. Methods: We sampled patients, patient contacts, healthcare workers, and the environment in four hospitals with recent C. auris outbreaks. Using standardized protocols, people were swabbed at different body sites...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Xiaojuan Wang, Jian Bing, Qiushi Zheng, Feifei Zhang, Jingbo Liu, Huizhen Yue, Li Tao, Han Du, Yina Wang, Hui Wang, Guanghua Huang
The emerging human fungal pathogen Candida auris has been recognized as a multidrug resistant species and is associated with high mortality. This fungus was first described in Japan in 2009 and has been reported in at least 18 countries on five continents. In this study, we report the first isolate of C. auris from the bronchoalveolar lavage fluid (BALF) of a hospitalized woman in China. Interestingly, this isolate is susceptible to all tested antifungals including amphotericin B, fluconazole, and caspofungin...
May 18, 2018: Emerging Microbes & Infections
Ryan Kean, Emily McKloud, Eleanor M Townsend, Leighann Sherry, Christopher Delaney, Brian L Jones, Craig Williams, Gordon Ramage
Candida auris has emerged as a significant clinical entity due to its ability to cause outbreaks within the healthcare setting. A key feature of its nosocomial lifestyle is its ability to transfer between patients, yet little is known about the mechanisms behind this. A panel of C. auris clinical isolates was screened for their planktonic and sessile susceptibilities to skin disinfection challenge using povidone iodine, chlorhexidine and hydrogen peroxide. C. auris biofilms displayed increased tolerance to these strategies compared to planktonic cells...
May 15, 2018: International Journal of Antimicrobial Agents
I S Schwartz, G W Hammond
Candida auris is a fungal pathogen that has recently emerged as a global threat to public health. It was first described in Japan in 2009 and has since been reported in 17 countries on five continents. This case report describes the first reported case of multidrug-resistant C. auris in Canada. In May 2017, a 64-year-old individual was evaluated for chronic otitis externa. Past medical history included a recent hospitalization in India for elective oral surgery that was complicated by an odontogenic brain abscess...
July 6, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
Peter G Pappas, Michail S Lionakis, Maiken Cavling Arendrup, Luis Ostrosky-Zeichner, Bart Jan Kullberg
Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Candida spp. are common commensal organisms in the skin and gut microbiota, and disruptions in the cutaneous and gastrointestinal barriers (for example, owing to gastrointestinal perforation) promote invasive disease...
May 11, 2018: Nature Reviews. Disease Primers
Purva Mathur, Fahmi Hasan, Pradeep Kumar Singh, Rajesh Malhotra, Kamini Walia, Anuradha Chowdhary
BACKGROUND: Candidemia is a potentially fatal infection with varied distribution of Candida species and their antifungal susceptibility profiles. The recent emergence of Candida auris in invasive candidiasis is a cause for concern. This study describes the profile of candidemia at an Indian tertiary care hospital and reports the emergence of Candida auris. METHODS: All patients diagnosed as having candidemia between 2012 to 2017 were studied. The isolates were identified using conventional methods, VITEK 2 and by the MALDI-TOF MS...
May 8, 2018: Mycoses
Tsun S N Ku, Carla J Walraven, Samuel A Lee
Candida auris is a rapidly emerging pathogen and is able to cause severe infections with high mortality rates. It is frequently misidentified in most clinical laboratories, thus requiring more specialized identification techniques. Furthermore, several clinical isolates have been found to be multidrug resistant and there is evidence of nosocomial transmission in outbreak fashion. Appropriate infection control measures will play a major role in controlling the management and spread of this pathogen. Unfortunately, there are very few data available on the effectiveness of disinfectants against C...
2018: Frontiers in Microbiology
Arnaud Riat, Dionysios Neofytos, Alix Coste, Stephan Harbarth, Alain Bizzini, Bruno Grandbastien, Jerome Pugin, Frederic Lamoth
No abstract text is available yet for this article.
April 26, 2018: Swiss Medical Weekly
Ruben Ramos, Diego H Caceres, Marilyn Perez, Nicole Garcia, Wendy Castillo, Erika Santiago, Jovanna Borace, Shawn R Lockhart, Elizabeth L Berkow, Lizbeth Hayer, Andres Espinosa-Bode, Jose Moreno, Brendan R Jackson, Jackeline Moran, Tom Chiller, Gloriela de Villarreal, Nestor Sosa, Snigdha Vallabhaneni
Candida duobushaemulonii , a yeast closely related to Candida auris, is thought to rarely cause infections, and is often misidentified. In October 2016, the Panamanian Ministry of Health implemented laboratory surveillance for C. auris Suspected C. auris isolates were forwarded to the national reference laboratory for identification by Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometry and antifungal susceptibility testing. During November 2016-May 2017, 17 of 36 (47%) isolates suspected to be C...
April 25, 2018: Journal of Clinical Microbiology
Laura Theill, Catiana Dudiuk, Soraya Morales-Lopez, Indira Berrio, José Yesid Rodríguez, Adriana Marin, Soledad Gamarra, Guillermo Garcia-Effron
BACKGROUND: Candida auris and Candida haemulonii are emerging and multiresistant pathogens. C. auris has produced hospital outbreaks and is misidentified by phenotypic-based methods. The only reliable identification methods are DNA sequencing and MALDI-TOF. AIMS: To develop a classical-PCR method capable of rapidly and accurately identify C. auris and C. haemulonii. METHODS: A multiplex PCR was carried out in one tube that included an internal control and oligonucleotides that specifically hybridize to the ITS2 region of C...
April 20, 2018: Revista Iberoamericana de Micología
Patricia Escandón, Diego H Cáceres, Andres Espinosa-Bode, Sandra Rivera, Paige Armstrong, Snigdha Vallabhaneni, Elizabeth L Berkow, Shawn R Lockhart, Tom Chiller, Brendan R Jackson, Carolina Duarte
No abstract text is available yet for this article.
April 20, 2018: MMWR. Morbidity and Mortality Weekly Report
Anke Kohlenberg, Marc J Struelens, Dominique L Monnet, Diamantis Plachouras, The Candida Auris Survey Collaborative Group
During 2013-2017, 620 cases of Candida auris were reported in the European Union/European Economic Area - 466 (75.2%) colonisations, 110 (17.7%) bloodstream infections, 40 (6.5%) other infections and four cases (0.6%) of unknown colonisation/infection status - the majority from four large outbreaks. Survey results showed that several countries lacked laboratory capacity and/or information on the occurrence of cases at national level. To prevent further spread, adequate laboratory capacity and infection control preparedness is required in Europe...
March 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Virginia Basso, Angie Garcia, Dat Q Tran, Justin B Schaal, Patti Tran, Diana Ngole, Younus Aqeel, Prasad Tongaonkar, André J Ouellette, Michael E Selsted
Systemic candidiasis is a growing health care concern becoming even more challenging due to the growing frequency of infections caused by multidrug resistant (MDR) Candida spp Thus there is an urgent need for new therapeutic approaches to candidiasis, including strategies bioinspired by insights into natural host defense against fungal pathogens. The antifungal properties of θ-defensins, macrocyclic peptides expressed in tissues of Old World monkeys, were investigated against a panel of drug sensitive and drug resistant clinical isolates of C...
April 2, 2018: Antimicrobial Agents and Chemotherapy
Marie-Elisabeth Bougnoux, Sophie Brun, Jean-Ralph Zahar
Outbreaks of healthcare-associated fungal infections have repeatedly been described over recent years, often caused by new or uncommon species. Candida auris , a recently described multidrug-resistant yeast species, is certainly the most worrisome species having caused several severe healthcare outbreaks of invasive infections, on four continents. Also, large nosocomial outbreaks due to uncommon fungal species such as Exserohilum rostratum and Sarocladium kiliense , were both linked to contamination of medical products, however the source of another outbreak, caused by Saprochaete clavata , remains unresolved...
2018: Antimicrobial Resistance and Infection Control
Johanna Rhodes, Alireza Abdolrasouli, Rhys A Farrer, Christina A Cuomo, David M Aanensen, Darius Armstrong-James, Matthew C Fisher, Silke Schelenz
Candida auris was first described in 2009, and it has since caused nosocomial outbreaks, invasive infections, and fungaemia across at least 19 countries on five continents. An outbreak of C. auris occurred in a specialized cardiothoracic London hospital between April 2015 and November 2016, which to date has been the largest outbreak in the UK, involving a total of 72 patients. To understand the genetic epidemiology of C. auris infection both within this hospital and within a global context, we sequenced the outbreak isolate genomes using Oxford Nanopore Technologies and Illumina platforms to detect antifungal resistance alleles and reannotate the C...
March 29, 2018: Emerging Microbes & Infections
Ana Belkin, Zeala Gazit, Nathan Keller, Ronen Ben-Ami, Anat Wieder-Finesod, Ana Novikov, Galia Rahav, Tal Brosh-Nissimov
A patient transferred from South Africa to Israel acquired a Candida auris infection. Phylogenetic analysis showed resemblance of C. auris to isolates from South Africa but not Israel, suggesting travel-associated infection. C. auris infection occurred weeks later in another patient at the same hospital, suggesting prolonged environmental persistence.
April 2018: Emerging Infectious Diseases
Adilia Warris
The newly recognised and emerging fungal species, Candida auris , has caused worldwide invasive infections and has been implicated in difficult to control hospital outbreaks. Challenges are encountered in the correct identification of this fungus as commonly used phenotypic and biochemical methods fail to differentiate C. auris from other Candida species. Its resistance profile, over 90% of isolates are fluconazole resistant and 35% are resistant to amphotericin, confronts clinicians with the restricted arsenal of antifungals and concerns about optimal treatment...
March 15, 2018: Archives of Disease in Childhood
Shawn R Lockhart, Elizabeth L Berkow, Nancy Chow, Rory M Welsh
Candida auris is a newly emerging species that was first identified in Asia in 2009 but has rapidly spread across the world. C. auris differs from most other Candida species in that antifungal resistance is the norm rather than the exception, it is a commensal of human skin rather than the human gut, and it can be easily transmitted from person to person in a healthcare setting. This review discusses the emergence of C. auris , global epidemiology, identification, antifungal susceptibility testing, and precautions to be taken when it is identified from a patient specimen...
July 1, 2017: Clinical Microbiology Newsletter
Shigekazu Iguchi, Ryo Mizushima, Keisuke Kamada, Yasutomo Itakura, Atsushi Yoshida, Yutaka Uzawa, Yuko Arai, Miyako Takaoka, Sumie Sato, Aeko Goto, Toshiko Karasawa, Naoki Tsuruoka, Daisuke Totsuka, Erika Ono, Manabu Nonaka, Koichi Makimura, Ken Kikuchi
No abstract text is available yet for this article.
March 22, 2018: Japanese Journal of Infectious Diseases
Mary Snayd, Feliciano Dias, Raymond W Ryan, Donna Clout, David B Banach
No abstract text is available yet for this article.
May 2018: Journal of Clinical Microbiology
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