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Candida auris

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https://www.readbyqxmd.com/read/28098553/biofilm-forming-capability-of-highly-virulent-multidrug-resistant-candida-auris
#1
Leighann Sherry, Gordon Ramage, Ryan Kean, Andrew Borman, Elizabeth M Johnson, Malcolm D Richardson, Riina Rautemaa-Richardson
The emerging multidrug-resistant yeast pathogen Candida auris has attracted considerable attention as a source of healthcare-associated infections. We report that this highly virulent yeast has the capacity to form antifungal resistant biofilms sensitive to the disinfectant chlorhexidine in vitro.
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28098529/multidrug-resistant-candida-haemulonii-and-c-auris-tel-aviv-israel
#2
Ronen Ben-Ami, Judith Berman, Ana Novikov, Edna Bash, Yael Shachor-Meyouhas, Shiri Zakin, Yasmin Maor, Jalal Tarabia, Vered Schechner, Amos Adler, Talya Finn
Candida auris and C. haemulonii are closely related, multidrug-resistant emerging fungal pathogens that are not readily distinguishable with phenotypic assays. We studied C. auris and C. haemulonii clinical isolates from 2 hospitals in central Israel. C. auris was isolated in 5 patients with nosocomial bloodstream infection, and C. haemulonii was found as a colonizer of leg wounds at a peripheral vascular disease clinic. Liberal use of topical miconazole and close contact among patients were implicated in C...
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28029734/investigation-of-the-first-seven-reported-cases-of-candida-auris-a-globally-emerging-invasive-multidrug-resistant-fungus-united-states-may-2013-august-2016
#3
EDITORIAL
S Vallabhaneni, A Kallen, S Tsay, N Chow, R Welsh, J Kerins, S K Kemble, M Pacilli, S R Black, E Landon, J Ridgway, T N Palmore, A Zelzany, E H Adams, M Quinn, S Chaturvedi, J Greenko, R Fernandez, K Southwick, E Y Furuya, D P Calfee, C Hamula, G Patel, P Barrett, P Lafaro, E L Berkow, H Moulton-Meissner, J Noble-Wang, R P Fagan, B R Jackson, S R Lockhart, A P Litvintseva, T M Chiller
November 11, 2016/65(44);1234-1237. What is already known about this topic? Candida auris is an emerging pathogenic fungus that has been reported from at least a dozen countries on four continents during 2009-2015. The organism is difficult to identify using traditional biochemical methods, some isolates have been found to be resistant to all three major classes of antifungal medications, and C. auris has caused health care-associated outbreaks. What is added by this report? This is the first description of C...
January 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27989986/emergence-of-candida-auris-an-international-call-to-arms
#4
EDITORIAL
Cornelius J Clancy, M Hong Nguyen
No abstract text is available yet for this article.
October 20, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27988485/simultaneous-emergence-of-multidrug-resistant-candida-auris-on-3-continents-confirmed-by-whole-genome-sequencing-and-epidemiological-analyses
#5
Shawn R Lockhart, Kizee A Etienne, Snigdha Vallabhaneni, Joveria Farooqi, Anuradha Chowdhary, Nelesh P Govender, Arnaldo Lopes Colombo, Belinda Calvo, Christina A Cuomo, Christopher A Desjardins, Elizabeth L Berkow, Mariana Castanheira, Rindidzani E Magobo, Kauser Jabeen, Rana J Asghar, Jacques F Meis, Brendan Jackson, Tom Chiller, Anastasia P Litvintseva
BACKGROUND: Candida auris, a multidrug-resistant yeast that causes invasive infections, was first described in 2009 in Japan and has since been reported from several countries. METHODS: To understand the global emergence and epidemiology of C. auris, we obtained isolates from 54 patients with C. auris infection from Pakistan, India, South Africa, and Venezuela during 2012-2015 and the type specimen from Japan. Patient information was available for 41 of the isolates...
January 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27987046/matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms-for-rapid-identification-of-micro-organisms-in-the-routine-clinical-microbiology-laboratory
#6
C Wattal, J K Oberoi, N Goel, R Raveendran, S Khanna
The study evaluates the utility of matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) Vitek MS for identification of microorganisms in the routine clinical microbiology laboratory. From May 2013 to April 2014, microbial isolates recovered from various clinical samples were identified by Vitek MS. In case of failure to identify by Vitek MS, the isolate was identified using the Vitek 2 system (bioMerieux, France) and serotyping wherever applicable or otherwise by nucleic acid-mediated methods...
December 16, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27881617/can-a-multi-drug-resistant-candida-auris-be-reliably-identified-in-clinical-microbiology-laboratories
#7
Masako Mizusawa, Heather Miller, Rachel Green, Richard Lee, Mariann Durante, Rosalie Perkins, Caroline Hewitt, Patricia J Simner, Karen C Carroll, Randall T Hayden, Sean X Zhang
Candida auris, an emerging multi-drug resistant yeast associated with high mortality, has been increasingly reported from outside of the US to cause outbreaks in the hospital settings (1).….
November 23, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27832049/investigation-of-the-first-seven-reported-cases-of-candida-auris-a-globally-emerging-invasive-multidrug-resistant-fungus-united-states-may-2013-august-2016
#8
Snigdha Vallabhaneni, Alex Kallen, Sharon Tsay, Nancy Chow, Rory Welsh, Janna Kerins, Sarah K Kemble, Massimo Pacilli, Stephanie R Black, Emily Landon, Jessica Ridgway, Tara N Palmore, Adrian Zelzany, Eleanor H Adams, Monica Quinn, Sudha Chaturvedi, Jane Greenko, Rafael Fernandez, Karen Southwick, E Yoko Furuya, David P Calfee, Camille Hamula, Gopi Patel, Patricia Barrett, Patricia Lafaro, Elizabeth L Berkow, Heather Moulton-Meissner, Judith Noble-Wang, Ryan P Fagan, Brendan R Jackson, Shawn R Lockhart, Anastasia P Litvintseva, Tom M Chiller
Candida auris, an emerging fungus that can cause invasive infections, is associated with high mortality and is often resistant to multiple antifungal drugs. C. auris was first described in 2009 after being isolated from external ear canal discharge of a patient in Japan (1). Since then, reports of C. auris infections, including bloodstream infections, have been published from several countries, including Colombia, India, Israel, Kenya, Kuwait, Pakistan, South Africa, South Korea, Venezuela, and the United Kingdom (2-7)...
November 11, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27821678/hospital-transmitted-candida-auris-infections-confirmed-in-the-us
#9
Michael McCarthy
No abstract text is available yet for this article.
November 7, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27777756/first-hospital-outbreak-of-the-globally-emerging-candida-auris-in-a-european-hospital
#10
Silke Schelenz, Ferry Hagen, Johanna L Rhodes, Alireza Abdolrasouli, Anuradha Chowdhary, Anne Hall, Lisa Ryan, Joanne Shackleton, Richard Trimlett, Jacques F Meis, Darius Armstrong-James, Matthew C Fisher
BACKGROUND: Candida auris is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission. We report an ongoing outbreak of C. auris in a London cardio-thoracic center between April 2015 and July 2016. This is the first report of C. auris in Europe and the largest outbreak so far. We describe the identification, investigation and implementation of control measures. METHODS: Data on C. auris case demographics, environmental screening, implementation of infection prevention/control measures, and antifungal susceptibility of patient isolates were prospectively recorded then analysed retrospectively...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27713213/identification-of-uncommon-candida-species-using-commercial-identification-systems
#11
Tae-Hyoung Kim, Oh Joo Kweon, Hye Ryoun Kim, Mi-Kyung Lee
Recently, several studies have revealed that commercial microbial identification systems do not accurately identify the uncommon causative species of candidiasis, including Candida famata, Meyerozyma guilliermondii, and C. auris. We investigated the accuracy of species-level identification in a collection of clinical isolates previously identified as C. famata (N = 38), C. lusitaniae (N = 1 2), and M. guilliermondii (N = 5) by the Vitek 2 system. All 55 isolates were re-analyzed by the Phoenix system (Becton Dickinson Diagnostics), two matrix-assisted laser desorption ionization-time of flight mass spectrometry analyzers (a Vitek MS and a Bruker Biotyper), and by sequencing of internal transcribed spacer (ITS) regions or 26S rRNA gene D1/D2 domains...
December 28, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27634564/multidrug-resistant-candida-auris-new-kid-on-the-block-in-hospital-associated-infections
#12
A Chowdhary, A Voss, J F Meis
Since being first reported in an ear swab in 2009, and in blood cultures in 2011, invasive infections with Candida auris have been reported in many countries across several continents. We review current knowledge of the epidemiology of this emerging multidrug-resistant pathogen. The importance of species identification and the inadequacies of many widely used identification systems are considered. We recommend that hospitals develop their own policies for the prevention and control of infections with this pathogen...
August 15, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27617098/whole-genome-sequencing-of-emerging-multidrug-resistant-candida-auris-isolates-in-india-demonstrates-low-genetic-variation
#13
C Sharma, N Kumar, R Pandey, J F Meis, A Chowdhary
Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phylogeny and amplified fragment length polymorphism typing methods report the C. auris population as clonal. Here, using whole genome sequencing analysis, we decipher for the first time that C. auris strains from four Indian hospitals were highly related, suggesting clonal transmission...
September 2016: New Microbes and New Infections
https://www.readbyqxmd.com/read/27547827/comparative-pathogenicity-of-united-kingdom-isolates-of-the-emerging-pathogen-candida-auris-and-other-key-pathogenic-candida-species
#14
Andrew M Borman, Adrien Szekely, Elizabeth M Johnson
Candida auris, first described in 2009, has since emerged as an important, multidrug-resistant, nosocomial agent of candidemia, with large outbreaks reported worldwide and high mortality rates associated with therapeutic failure. The current study employed C. auris isolates from a variety of centers in the United Kingdom to evaluate the pathogenicity of this emerging pathogen compared to that of other common pathogenic yeast species in the invertebrate Galleria mellonella infection model. We showed that C...
July 2016: MSphere
https://www.readbyqxmd.com/read/27452195/first-report-of-candida-auris-in-america-clinical-and-microbiological-aspects-of-18-episodes-of-candidemia
#15
Belinda Calvo, Analy S A Melo, Armindo Perozo-Mena, Martin Hernandez, Elaine Cristina Francisco, Ferry Hagen, Jacques F Meis, Arnaldo Lopes Colombo
OBJECTIVES: Characterization of a hospital outbreak of Candida auris candidemia that involved 18 critically ill patients in Venezuela. METHOD: Bloodstream isolates of C. auris obtained from 18 patients admitted at a medical center in Maracaibo, between March, 2012 and July, 2013 were included. Species identification was confirmed by ITS rDNA sequencing. Isolates were subsequently typed by amplified fragment length polymorphism fingerprinting (AFLP). Susceptibility testing was performed according to CLSI...
October 2016: Journal of Infection
https://www.readbyqxmd.com/read/27379069/identification-of-candida-haemulonii-complex-species-use-of-clinprotools-tm-to-overcome-limitations-of-the-bruker-biotyper-tm-vitek-ms-tm-ivd-and-vitek-ms-tm-ruo-databases
#16
Rafaella C Grenfell, Afonso R da Silva Junior, Gilda M B Del Negro, Regina B Munhoz, Viviane M F Gimenes, Diego M Assis, Anna C Rockstroh, Adriana L Motta, Flavia Rossi, Luiz Juliano, Gil Benard, João N de Almeida Júnior
Candida haemulonii is now considered a complex of two species and one variety: C. haemulonii sensu stricto, Candida duobushaemulonii and the variety C. haemulonii var. vulnera. Identification (ID) of these species is relevant for epidemiological purposes and for therapeutic management, but the different phenotypic commercial systems are unable to provide correct species ID for these emergent pathogens. Hence, we evaluated the MALDI-TOF MS performance for the ID of C. haemulonii species, analyzing isolates/strains of C...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27292939/identification-and-typing-of-the-emerging-pathogen-candida-auris-by-matrix-assisted-laser-desorption-ionisation-time-of-flight-mass-spectrometry
#17
Victoria Girard, Sandrine Mailler, Marion Chetry, Céline Vidal, Géraldine Durand, Alex van Belkum, Arnaldo L Colombo, Ferry Hagen, Jacques F Meis, Anuradha Chowdhary
Candida auris is an emerging antifungal resistant yeast species causing nosocomial and invasive infections, emphasising the need of improved diagnostics and epidemiological typing methods. We show that MALDI-TOF VITEK-MS followed by amplified length polymorphisms allows for accurate species identification and subsequent epidemiological characterisation of strains encountered during potential outbreaks.
August 2016: Mycoses
https://www.readbyqxmd.com/read/26548511/evidence-of-genotypic-diversity-among-candida-auris-isolates-by-multilocus-sequence-typing-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-and-amplified-fragment-length-polymorphism
#18
A Prakash, C Sharma, A Singh, P Kumar Singh, A Kumar, F Hagen, N P Govender, A L Colombo, J F Meis, A Chowdhary
Candida auris is a multidrug-resistant nosocomial bloodstream pathogen that has been reported from Asian countries and South Africa. Herein, we studied the population structure and genetic relatedness among 104 global C. auris isolates from India, South Africa and Brazil using multilocus sequence typing (MLST), amplified fragment length polymorphism (AFLP) fingerprinting and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). RPB1, RPB2 and internal transcribed spacer (ITS) and D1/D2 regions of the ribosomal DNA were sequenced for MLST...
March 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/26346253/draft-genome-of-a-commonly-misdiagnosed-multidrug-resistant-pathogen-candida-auris
#19
Sharanya Chatterjee, Shuba Varshini Alampalli, Rishi Kumar Nageshan, Sivarajan T Chettiar, Sangeeta Joshi, Utpal S Tatu
BACKGROUND: Candida auris is a multidrug resistant, emerging agent of fungemia in humans. Its actual global distribution remains obscure as the current commercial methods of clinical diagnosis misidentify it as C. haemulonii. Here we report the first draft genome of C. auris to explore the genomic basis of virulence and unique differences that could be employed for differential diagnosis. RESULTS: More than 99.5 % of the C. auris genomic reads did not align to the current whole (or draft) genome sequences of Candida albicans, Candida lusitaniae, Candida glabrata and Saccharomyces cerevisiae; thereby indicating its divergence from the active Candida clade...
September 7, 2015: BMC Genomics
https://www.readbyqxmd.com/read/26184929/draft-genome-sequence-of-a-fluconazole-resistant-candida-auris-strain-from-a-candidemia-patient-in-india
#20
Cheshta Sharma, Nitin Kumar, Jacques F Meis, Rajesh Pandey, Anuradha Chowdhary
Candida auris is a multidrug-resistant yeast incriminated in a wide spectrum of invasive infections, especially in intensive care settings. The first draft genome sequence of C. auris, VPCI 479/P/13, from a case with fungemia was sequenced using the Illumina MiSeq platform. The estimated genome size is 12.3 Mb, with 6,675 coding sequences.
2015: Genome Announcements
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