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https://www.readbyqxmd.com/read/27913228/pd-l1-immunohistochemistry-assays-for-lung-cancer-results-from-phase-1-of-the-blueprint-pd-l1-ihc-assay-comparison-project
#1
Fred R Hirsch, Abigail McElhinny, Dave Stanforth, James Ranger-Moore, Malinka Jansson, Karina Kulangara, William Richardson, Penny Towne, Debra Hanks, Bharathi Vennapusa, Amita Mistry, Rasika Kalamegham, Steve Averbuch, James Novotny, Eric Rubin, Kenneth Emancipator, Ian McCaffery, J Andrew Williams, Jill Walker, John Longshore, Ming S Tsao, Keith M Kerr
BACKGROUND: The "Blueprint PD-L1 IHC Assay Comparison Project" is an industrial-academic collaborative partnership to provide information on the analytical and clinical comparability of four PD-L1 IHC assays used in clinical trials. METHODS: 39 NSCLC tumors were stained with four PD-L1 IHC assays (22C3, 28-8, SP 142 and SP 263) as used in the clinical trials. Three experts in interpreting their respective assays independently evaluated the percentages of tumor and immune cells staining positive at any intensity...
November 29, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27904974/heat-stress-affects-carbohydrate-metabolism-during-cold-induced-sweetening-of-potato-solanum-tuberosum-l
#2
Derek J Herman, Lisa O Knowles, N Richard Knowles
Tolerance to heat stress for retention of low-temperature sweetening-resistant phenotype in potato is conferred by insensitivity of acid invertase activity to cold induction. Heat stress exacerbated cold sweetening (buildup of reducing sugars) of the LTS (low-temperature sweetening)-susceptible potato (Solanum tuberosum L.) cultivars, Ranger Russet and Russet Burbank, and completely abolished the resistance to cold sweetening in the LTS-resistant cultivars/clones, Sage Russet, GemStar Russet, POR06V12-3 and A02138-2...
November 30, 2016: Planta
https://www.readbyqxmd.com/read/27899340/ecological-momentary-assessment-of-adolescent-problems-coping-efficacy-and-mood-states-using-a-mobile-phone-app-an-exploratory-study
#3
Rachel Kenny, Barbara Dooley, Amanda Fitzgerald
BACKGROUND: Mobile technologies have the potential to be used as innovative tools for conducting research on the mental health and well-being of young people. In particular, they have utility for carrying out ecological momentary assessment (EMA) research by capturing data from participants in real time as they go about their daily lives. OBJECTIVE: The aim of this study was to explore the utility of a mobile phone app as a means of collecting EMA data pertaining to mood, problems, and coping efficacy in a school-based sample of Irish young people...
November 29, 2016: JMIR Mental Health
https://www.readbyqxmd.com/read/27837497/the-changing-epidemiology-of-invasive-fungal-infections
#4
David A Enoch, Huina Yang, Sani H Aliyu, Christianne Micallef
Invasive fungal infections (IFI) are an emerging problem worldwide with invasive candidiasis and candidemia responsible for the majority of cases. This is predominantly driven by the widespread adoption of aggressive immunosuppressive therapy among certain patient populations (e.g., chemotherapy, transplants) and the increasing use of invasive devices such as central venous catheters (CVCs). The use of new immune modifying drugs has also opened up an entirely new spectrum of patients at risk of IFIs. While the epidemiology of candida infections has changed in the last decade, with a gradual shift from C...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27760209/pristane-accelerated-autoimmune-disease-in-swr-x-nzb-f1-mice-leads-to-prominent-tubulointerstitial-inflammation-and-human-lupus-nephritis-like-fibrosis
#5
Agnes Gardet, Wei C Chou, Taylor L Reynolds, Diana B Velez, Kai Fu, Julia M Czerkowicz, Jeffrey Bajko, Ann M Ranger, Normand Allaire, Hannah M Kerns, Sarah Ryan, Holly M Legault, Robert W Dunstan, Robert Lafyatis, Matvey Lukashev, Joanne L Viney, Jeffrey L Browning, Dania Rabah
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelerated mouse model of lupus using pristane treatment in SNF1 (SWR X NZB F1) lupus prone mice (pristane-SNF1 mice). Pristane treatment in SNF1 mice accelerated the onset and progression of proteinuria, autoantibody production, immune complex deposition and development of renal lesions...
2016: PloS One
https://www.readbyqxmd.com/read/27760201/catastrophic-decline-of-world-s-largest-primate-80-loss-of-grauer-s-gorilla-gorilla-beringei-graueri-population-justifies-critically-endangered-status
#6
Andrew J Plumptre, Stuart Nixon, Deo K Kujirakwinja, Ghislain Vieilledent, Rob Critchlow, Elizabeth A Williamson, Radar Nishuli, Andrew E Kirkby, Jefferson S Hall
Grauer's gorilla (Gorilla beringei graueri), the World's largest primate, is confined to eastern Democratic Republic of Congo (DRC) and is threatened by civil war and insecurity. During the war, armed groups in mining camps relied on hunting bushmeat, including gorillas. Insecurity and the presence of several militia groups across Grauer's gorilla's range made it very difficult to assess their population size. Here we use a novel method that enables rigorous assessment of local community and ranger-collected data on gorilla occupancy to evaluate the impacts of civil war on Grauer's gorilla, which prior to the war was estimated to number 16,900 individuals...
2016: PloS One
https://www.readbyqxmd.com/read/27755079/performance-of-glidescope-ranger-video-laryngoscope-for-prehospital-emergency-intubation
#7
Fu Shan Xue, Gui Zhen Yang, Chao Sun
No abstract text is available yet for this article.
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27753571/application-of-athletic-movement-tests-that-predict-injury-risk-in-a-military-population-development-of-normative-data
#8
Deydre S Teyhen, Scott W Shaffer, Robert J Butler, Stephen L Goffar, Kyle B Kiesel, Daniel I Rhon, Robert E Boyles, Daniel J McMillian, Jared N Williamson, Phillip J Plisky
: Performance on movement tests helps to predict injury risk in a variety of physically active populations. Understanding baseline measures for normal is an important first step. OBJECTIVES: Determine differences in physical performance assessments and describe normative values for these tests based on military unit type. METHODS: Assessment of power, balance, mobility, motor control, and performance on the Army Physical Fitness Test were assessed in a cohort of 1,466 soldiers...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27711222/association-between-traffic-air-pollution-and-reduced-forced-vital-capacity-a-study-using-personal-monitors-for-outdoor-workers
#9
Ubiratan Paula Santos, Maria Lúcia Siqueira Bueno Garcia, Alfésio Luís Ferreira Braga, Luiz Alberto Amador Pereira, Chin An Lin, Paulo Afonso de André, Carmen Diva Saldiva de André, Julio da Motta Singer, Paulo Hilário Nascimento Saldiva
BACKGROUND: The effects of outdoor air pollution on lung function in adults are still controversial. OBJECTIVE: Evaluate the effects of exposure to different levels of traffic-generated PM2.5 on workers' lung functions in São Paulo, Brazil. METHODS: To cover a wide range of exposures, 101 non-smoking workers from three occupations (taxi drivers, traffic controllers, and forest rangers) were selected for the study. After clinical evaluation, the participants were scheduled to attend four consecutive weekly visits in which they received a 24-hour personal PM2...
2016: PloS One
https://www.readbyqxmd.com/read/27647607/rouviere-s-sulcus-aspects-of-incorporating-this-valuable-sign-for-laparoscopic-cholecystectomy
#10
Stuart Lockhart, Gurpreet Singh-Ranger
Laparoscopic cholecystectomy is one of the most common procedures performed worldwide. Despite advances in technique, injury to the common bile duct and blood vessels still occurs. Rouviere's sulcus, a naturally occurring cleft in the right lobe, anterior to Segment 1, occurs in over 80% of normal livers. It is a useful, but often ignored, anatomical landmark for beginning dissection of Calot's triangle, and also for confirming its location. Despite this, its usefulness is not widely known or appreciated by general surgeons...
September 16, 2016: Asian Journal of Surgery
https://www.readbyqxmd.com/read/27548230/flood-stress-as-a-technique-to-assess-preventive-insecticide-and-fungicide-treatments-for-protecting-trees-against-ambrosia-beetles
#11
Christopher M Ranger, Peter B Schultz, Michael E Reding, Steven D Frank, Debra E Palmquist
Ambrosia beetles tunnel into the heartwood of trees where they cultivate and feed upon a symbiotic fungus. We assessed the effectiveness of flood stress for making Cercis canadensis L. and Cornus florida L. trees attractive to attack as part of insecticide and fungicide efficacy trials conducted in Ohio and Virginia. Since female ambrosia beetles will not begin ovipositing until their symbiotic fungus is established within the host, we also assessed pre-treatment of trees with permethrin, azoxystrobin, and potassium phosphite on fungal establishment and beetle colonization success...
August 18, 2016: Insects
https://www.readbyqxmd.com/read/27529575/patient-satisfaction-with-in-home-telerehabilitation-after-total-knee-arthroplasty-results-from-a-randomized-controlled-trial
#12
Hélène Moffet, Michel Tousignant, Sylvie Nadeau, Chantal Mérette, Patrick Boissy, Hélène Corriveau, François Marquis, François Cabana, Étienne L Belzile, Pierre Ranger, Ronald Dimentberg
BACKGROUND AND INTRODUCTION: Telerehabilitation after total knee arthroplasty (TKA) is supported by strong evidence on the effectiveness of such intervention and from a cost-benefit point of view. Satisfaction of patients toward in-home telerehabilitation after TKA has not yet been examined thoroughly in large-scale clinical trials. This study aims to compare satisfaction level of patients following in-home telerehabilitation (TELE) after TKA to one of the patients following a usual face-to-face home visit (STD) rehabilitation...
August 16, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/27525539/the-role-of-the-middle-lumbar-fascia-on-spinal-mechanics-a-human-biomechanical-assessment
#13
Tom A Ranger, Nicolas Newell, Caroline A Grant, Priscilla J Barker, Mark J Pearcy
STUDY DESIGN: Biomechanical experiment. OBJECTIVE: The aims of this study were to test the effect of fascial tension on lumbar segmental axial rotation and lateral flexion and the effect of the angle of fascial attachment. SUMMARY OF BACKGROUND DATA: Tension in the middle layer of lumbar fascia has been demonstrated to affect mechanical properties of lumbar segmental flexion and extension in the neutral zone. However, the effect of tension on segmental axial rotation and lateral flexion has not been investigated...
August 12, 2016: Spine
https://www.readbyqxmd.com/read/27509394/effects-of-oxygen-impurities-on-glass-formation-ability-in-zr2cu-alloy
#14
Zhanyu Wang, Li Huang, G Q Yue, B Shen, F Dong, R J Zhang, Y X Zheng, S Y Wang, C Z Wang, M J Kramer, K M Ho, L Y Chen
Using ab initio molecular dynamics simulations, we show that oxygen (O) impurities have a noticeable influence on the glass-formation ability (GFA) in Zr2Cu alloy. Cu-centered icosahedral clusters and Zr-centered Kasper polyhedra are the dominate short-range orders in undercooled Zr2Cu liquid which are most likely to be responsible for the glass formation in Zr2Cu systems. When O is introduced, a Zr octahedron is formed around the O impurity. Most of the Zr atoms in the octahedron also serve as the bridging atoms for cross-linked Kasper polyhedral network, resulting in an O-centered medium range order (MRO) structure...
September 1, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27462475/appendagitis-following-diagnostic-laparoscopy-and-laparoscopic-appendicectomy
#15
R Kumar, R F Bamford, D Kumar, G Singh-Ranger
Appendagitis is an uncommon clinical entity, often not recognised, and mistaken for more serious infective conditions. We describe a proven case of appendagitis which occurred after confirmed appendicitis. We postulate that this condition can coexist with appendicitis and indeed may be the result of coinflammation. This has several implications. Firstly, clinicians must retain an index of suspicion for this condition in a patient with localised abdominal pain which occurs after appendicitis. Secondly, it would be reasonable to suggest careful examination of colocated appendages in a patient with an otherwise normal-appearing appendix...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27441584/combining-human-computing-and-machine-learning-to-make-sense-of-big-aerial-data-for-disaster-response
#16
Ferda Ofli, Patrick Meier, Muhammad Imran, Carlos Castillo, Devis Tuia, Nicolas Rey, Julien Briant, Pauline Millet, Friedrich Reinhard, Matthew Parkan, Stéphane Joost
Aerial imagery captured via unmanned aerial vehicles (UAVs) is playing an increasingly important role in disaster response. Unlike satellite imagery, aerial imagery can be captured and processed within hours rather than days. In addition, the spatial resolution of aerial imagery is an order of magnitude higher than the imagery produced by the most sophisticated commercial satellites today. Both the United States Federal Emergency Management Agency (FEMA) and the European Commission's Joint Research Center (JRC) have noted that aerial imagery will inevitably present a big data challenge...
March 2016: Big Data
https://www.readbyqxmd.com/read/27412195/developing-a-media-moisture-threshold-for-nurseries-to-reduce-tree-stress-and-ambrosia-beetle-attacks
#17
Steven D Frank, Christopher M Ranger
Exotic ambrosia beetles are among the most damaging pests of trees grown in nurseries. The primary pests Xylosandrus crassiusculus Motschulsky and Xylosandrus germanus Blandford use ethanol to locate vulnerable trees. Research, primarily with X. germanus, has shown that flood-stressed trees emit ethanol and are preferentially attacked by ambrosia beetles. Our goal was to develop a media (also called potting soil) moisture threshold as an integrated pest management (IPM) tactic and assess grower practices that lead to ambrosia beetle attacks...
August 2016: Environmental Entomology
https://www.readbyqxmd.com/read/27372881/the-predictive-validity-of-common-risk-assessment-tools-in-men-with-intellectual-disabilities-and-problematic-sexual-behaviors
#18
J Paul Fedoroff, Deborah Richards, Rebekah Ranger, Susan Curry
This CIHR-funded study examined whether certain current risk assessment tools were effective in appraising risk of recidivism in a sample of sex offenders with intellectual disabilities (ID). Fifty men with ID who had engaged in problematic sexual behavior (PSB) were followed for an average of 2.5 years. Recidivism was defined and measured as any illegal or problematic behavior, as well as any problematic but not necessarily illegal behavior. At the beginning of the study, each participant was rated on two risk assessment tools: the Violence Risk Appraisal Guide (VRAG) and the Sex Offender Risk Appraisal Guide (SORAG)...
October 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27368699/the-impact-of-a-standardized-order-set-for-the-management-of-non-hip-fragility-fractures-in-a-fracture-liaison-service
#19
A Senay, J Delisle, M Giroux, G Y Laflamme, S Leduc, M Malo, H Nguyen, P Ranger, J C Fernandes
: We analysed the impact of a standardized order set empowering staff nurses to independently manage a Fracture Liaison Service over a 9-month period. Nurses identified between 30 and 70 % of non-hip fragility fractures to the unit in charge of management over time. The latter managed 58 % of referred patients. INTRODUCTION: The main goal of this study was to evaluate the impact of a standardized order set empowering nurses to independently manage a fracture liaison service (FLS)...
July 1, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27318853/her2-intratumoral-heterogeneity-analyses-by-concurrent-her2-gene-and-protein-assessment-for-the-prognosis-of-her2-negative-invasive-breast-cancer-patients
#20
Sasagu Kurozumi, Mary Padilla, Masafumi Kurosumi, Hiroshi Matsumoto, Kenichi Inoue, Jun Horiguchi, Izumi Takeyoshi, Tetsunari Oyama, Jim Ranger-Moore, D Craig Allred, Eslie Dennis, Hiroaki Nitta
HER2 gene-protein assay (GPA) is a new method for the simultaneous evaluation of HER2 immunohistochemistry (IHC) and HER2 dual in situ hybridization (DISH) on single tissue sections of breast cancer. We investigated the presence of HER2 gene and protein discrepancy and HER2-heterogeneity using HER2-GPA. HER2 status was analyzed for the correlation between the presence of HER2-heterogeneity and patient prognosis. Consecutive 280 invasive breast cancer were examined. Statuses of HER2 protein and gene were evaluated in whole tumor sections of HER2 GPA slides...
July 2016: Breast Cancer Research and Treatment
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