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https://www.readbyqxmd.com/read/29322318/total-knee-arthroplasty-with-unexplained-pain-new-insights-from-kinematics
#1
Célia Planckaert, Gabriel Larose, Pierre Ranger, Marc Lacelle, Alexandre Fuentes, Nicola Hagemeister
INTRODUCTION: Up to 20% of total knee arthroplasty patients remain unsatisfied post-surgery, and a large proportion of them report anterior knee pain. This study aims to verify whether patients who experience anterior knee pain after total knee arthroplasty (TKA) will exhibit kinematic characteristics similar to those associated with patellofemoral syndrome, including in the frontal and transverse planes. MATERIALS AND METHODS: Using four different assessment methods [radiological, patient-reported outcome, musculoskeletal assessment with functional performance testing, and a 3D kinematic assessment during gait], the clinical and 3D knee kinematic profiles of three groups were compared: a painful and an asymptomatic TKA group and a healthy control group...
January 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29259995/anti-lingo-1-has-no-detectable-immunomodulatory-effects-in-preclinical-and-phase-1-studies
#2
Ann Ranger, Soma Ray, Suzanne Szak, Andrea Dearth, Norm Allaire, Ronald Murray, Rebecca Gardner, Diego Cadavid, Sha Mi
Objective: To evaluate whether the anti-LINGO-1 antibody has immunomodulatory effects. Methods: Human peripheral blood mononuclear cells (hPBMCs), rat splenocytes, and rat CD4+ T cells were assessed to determine whether LINGO-1 was expressed and was inducible. Anti-LINGO-1 Li81 (0.1-30 μg/mL) effect on proliferation/cytokine production was assessed in purified rat CD4+ T cells and hPBMCs stimulated with antibodies to CD3 +/- CD28. In humans, the effect of 2 opicinumab (anti-LINGO-1/BIIB033; 30, 60, and 100 mg/kg) or placebo IV administrations was evaluated in RNA from blood and CSF samples taken before and after administration in phase 1 clinical trials; paired samples were assessed for differentially expressed genes by microarray...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29236564/views-from-the-field-medical-student-experiences-and-perceptions-of-interprofessional-learning-and-collaboration-in-rural-settings
#3
David S Thompson, Jacques Abourbih, Lorraine Carter, Gayle Adams-Carpino, Sue Berry, Lisa E Graves, Nichole J Ranger
Exploring the perceived environment where students are educated, as well as where they practice, is particularly important for educators and practitioners working in situations of interprofessional rural and remote health. In this study, we explored the perceptions of undergraduate medical students regarding interprofessionalism across their four-year undergraduate program which focuses on rural health. A thematic content analysis of the text-data was conducted on a convenience sample of 47 student responses to essay questions across four cohorts of a four-year undergraduate medical program...
December 13, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29141336/-data-distribution-and-transformation-in-population-based-sampling-survey-of-viral-load-in-hiv-positive-men-who-have-sex-with-men-in-china
#4
Z Dou, J Chen, Z Jiang, W L Song, J Xu, Z Y Wu
Objective: To understand the distribution of population viral load (PVL) data in HIV infected men who have sex with men (MSM), fit distribution function and explore the appropriate estimating parameter of PVL. Methods: The detection limit of viral load (VL) was ≤ 50 copies/ml. Box-Cox transformation and normal distribution tests were used to describe the general distribution characteristics of the original and transformed data of PVL, then the stable distribution function was fitted with test of goodness of fit...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29136657/contrasts-in-the-marine-ecosystem-of-two-macaronesian-islands-a-comparison-between-the-remote-selvagens-reserve-and-madeira-island
#5
Alan M Friedlander, Enric Ballesteros, Sabrina Clemente, Emanuel J Gonçalves, Andrew Estep, Paul Rose, Enric Sala
The islands of Madeira and Selvagens are less than 300 km apart but offer a clear contrast between a densely populated and highly developed island (Madeira), and a largely uninhabited and remote archipelago (Selvagens) within Macaronesia in the eastern Atlantic. The Madeira Archipelago has ~260,000 inhabitants and receives over six million visitor days annually. The Selvagens Islands Reserve is one of the oldest nature reserves in Portugal and comprises two islands and several islets, including the surrounding shelf to a depth of 200 m...
2017: PloS One
https://www.readbyqxmd.com/read/29118405/extreme-behavioural-shifts-by-baboons-exploiting-risky-resource-rich-human-modified-environments
#6
Gaelle Fehlmann, M Justin O'Riain, Catherine Kerr-Smith, Stephen Hailes, Adrian Luckman, Emily L C Shepard, Andrew J King
A range of species exploit anthropogenic food resources in behaviour known as 'raiding'. Such behavioural flexibility is considered a central component of a species' ability to cope with human-induced environmental changes. Here, we study the behavioural processes by which raiding male chacma baboons (Papio ursinus) exploit the opportunities and mitigate the risks presented by raiding in the suburbs of Cape Town, South Africa. Ecological sampling and interviews conducted with 'rangers' (employed to manage the baboons' space use) revealed that baboons are at risk of being herded out of urban spaces that contain high-energy anthropogenic food sources...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110709/the-prevalence-incidence-and-prevention-of-plasmodium-falciparum-infections-in-forest-rangers-in-bu-gia-map-national-park-binh-phuoc-province-vietnam-a-pilot-study
#7
Do Hung Son, Nguyen Thuy-Nhien, Lorenz von Seidlein, Truong Le Phuc-Nhi, Ngo Thi Phu, Nguyen Thi Kim Tuyen, Nguyen Huyen Tran, Nguyen Van Dung, Bui Van Quan, Nicholas P J Day, Arjen M Dondorp, Nicholas J White, Guy E Thwaites, Tran Tinh Hien
BACKGROUND: Prophylaxis for high-risk populations, such as forest workers, could be one component for malaria elimination in the Greater Mekong Sub-region. A study was conducted to assess the malaria incidence in forest rangers and the feasibility of malaria prophylaxis for rangers sleeping in forest camps. METHODS: Forest rangers deployed in the Bu Gia Map National Park, Vietnam were invited to participate in the study. Plasmodium infections were cleared using presumptive treatment, irrespective of malaria status, with a 3-day course dihydroartemisinin/piperaquine (DP) and a 14-day course of primaquine...
November 6, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29100217/nontraumatic-emergency-laparotomy-surgical-principles-similar-to-trauma-need-to-be-adopted
#8
Deepak Singh-Ranger, Edmund Leung, Mei-Ling Lau-Robinson, Sean Ramcharan, James Francombe
OBJECTIVES: In 2011, the Royal College of Surgeons published Emergency Surgery: Standards for Unscheduled Care in response to variable clinical outcomes for emergency surgery. The purpose of this study was to examine whether different treatment modalities would alter survival. METHODS: All patients who underwent emergency laparotomy between April 2011 and December 2012 at Warwick Hospital (Warwick, UK) were included retrospectively. Information relating to their demographics; preoperative score; primary pathology; timing of surgery; intraoperative details; and postoperative outcome, including 30-day mortality, were collated for statistical analysis...
November 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29069311/interaction-of-insecticide-and-media-moisture-on-ambrosia-beetle-coleoptera-curculionidae-attacks-on-selected-ornamental-trees
#9
Steven D Frank, Amanda L Anderson, Christopher M Ranger
Exotic ambrosia beetles, particularly Xylosandrus crassiusculus (Motschulsky) (Coleoptera: Curculionidae: Scolytinae) and Xylosandrus germanus (Blandford) (Coleoptera: Curculionidae: Scolytinae), are among the most damaging pests of ornamental trees in nurseries. Growers have had few tactics besides insecticide applications to reduce ambrosia beetle attacks but recent research has shown that attacks may be reduced by maintaining media moisture below a 50% threshold thereby reducing flood stress. We compared the efficacy of managing media moisture and insecticide applications for reducing ambrosia beetle attacks on three ornamental tree species in North Carolina...
October 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29059803/a-course-in-prosthetics-for-the-developing-world-merging-education-research-and-industry-to-teach-biomedical-design-for-social-impact
#10
Bryan J Ranger, Aikaterini Mantzavinou
Under the auspices of the MIT D-Lab, a team of graduate students has instructed a course since 2008 that centers around teaching low-cost prosthetic design for resource-constrained environments. Recently, the course has evolved into a fully immersive design experience that pairs student teams with real-life international stakeholders and industry partners. Following this structure, projects initiated as part of the course have been tested at field sites around the world, stimulated further research, advanced student careers, raised additional grant money, and generated peer-reviewed publications and intellectual property...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28980462/treatment-of-femoropopliteal-atherosclerotic-lesions-using-the-ranger-paclitaxel-coated-balloon-catheter-12-month-results-from-an-all-comers-registry
#11
Michael Lichtenberg, Peter von Bilderling, Jürgen Ranft, Kathrin Niemöller, Holger Grell, Lucas Briner, Françoise Saucy, Tienush Rassaf, Frank Breuckmann
BACKGROUND: To evaluate 12-month effectiveness of the endovascular treatment of femoropopliteal (FP) atherosclerotic lesions with the Ranger drug-coated balloon (DCB) in a real-world setting. METHODS: In this prospective, observational, multicenter trial (ClinicalTrials.gov Identifier: NCT02462005) 172 consecutive patients with 226 de novo, restenosed, or reoccluded native superficial femoral and/or popliteal artery lesions were treated with the Ranger paclitaxel- coated balloon angioplasty...
October 3, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28961948/trap-style-bait-and-height-deployments-in-black-walnut-tree-canopies-help-inform-monitoring-strategies-for-bark-and-ambrosia-beetles-coleoptera-curculionidae-scolytinae
#12
COMPARATIVE STUDY
William E Klingeman, Alicia M Bray, Jason B Oliver, Christopher M Ranger, Debra E Palmquist
Knowledge about which bark and ambrosia beetle species are active and at what heights in black walnut canopies is not well understood. Neither is the role of these beetles in spreading Thousand Cankers Disease. To assist with future planned research, which will assess the extent to which these beetle species are associated with Geosmithia morbida Kolařík, Freeland, Utley, and Tisserat (Ascomycota: Hypocreales: Bionectriaceae), experiments were undertaken to monitor bark and ambrosia beetles in urban landscapes and parks in Tennessee between 2011 and 2013...
October 1, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28826318/the-lived-experience-of-black-nurse-faculty-in-predominantly-white-schools-of-nursing
#13
Lisa Whitfield-Harris, Joan Such Lockhart, Richard Zoucha, Rumay Alexander
PURPOSE: This study explored the experiences of Black nurse faculty employed in predominantly White schools of nursing. High attrition rates of this group were noted in previous literature. Understanding their experiences is important to increase nurse diversity. DESIGN: Hermeneutic phenomenology was used to explore the experiences of 15 Black nurse faculty using interviews. FINDINGS: Four themes were extracted as the following: cultural norms of the workplace, coping with improper assets, life as a "Lone Ranger," and surviving the workplace environment...
March 1, 2017: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/28807073/a-comparison-of-paramedic-first-pass-endotracheal-intubation-success-rate-of-the-vividtrac-vt-a-100-glidescope-ranger-and-direct-laryngoscopy-under-simulated-prehospital-cervical-spinal-immobilization-conditions-in-a-cadaveric-model
#14
Ryan Hodnick, Tony Zitek, Kellen Galster, Stephen Johnson, Bryan Bledsoe, Daniel Ebbs
OBJECTIVE: The primary goal of this study was to compare paramedic first pass success rate between two different video laryngoscopes and direct laryngoscopy (DL) under simulated prehospital conditions in a cadaveric model. METHODS: This was a non-randomized, group-controlled trial in which five non-embalmed, non-frozen cadavers were intubated under prehospital spinal immobilization conditions using DL and with both the GlideScope Ranger (GL; Verathon Inc, Bothell, Washington USA) and the VividTrac VT-A100 (VT; Vivid Medical, Palo Alto, California USA)...
December 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28805805/whole-tumor-section-quantitative-image-analysis-maximizes-between-pathologists-reproducibility-for-clinical-immunohistochemistry-based-biomarkers
#15
Michael Barnes, Chukka Srinivas, Isaac Bai, Judith Frederick, Wendy Liu, Anindya Sarkar, Xiuzhong Wang, Yao Nie, Bryce Portier, Monesh Kapadia, Olcay Sertel, Elizabeth Little, Bikash Sabata, Jim Ranger-Moore
Pathologists have had increasing responsibility for quantitating immunohistochemistry (IHC) biomarkers with the expectation of high between-reader reproducibility due to clinical decision-making especially for patient therapy. Digital imaging-based quantitation of IHC clinical slides offers a potential aid for improvement; however, its clinical adoption is limited potentially due to a conventional field-of-view annotation approach. In this study, we implemented a novel solely morphology-based whole tumor section annotation strategy to maximize image analysis quantitation results between readers...
August 14, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28794842/mega-acer-kit%C3%A2-is-more-effective-for-warming-the-intravenous-fluid-than-ranger%C3%A2-and-thermosens%C3%A2-at-440-ml-h-of-infusion-rate-an-experimental-performance-study
#16
Dong Joon Kim, Sang Hun Kim, Keum Young So, Tae Hun An
BACKGROUND: Few studies have investigated the effectiveness of intravenous fluid warmers at low and moderate flow rates below 1,000 ml/h. In this study, we compared the effectiveness of three different fluid warmers at a low flow rate (440 ml/h). METHODS: We experimentally investigated the fluid warming performances of Mega Acer Kit® (Group M, n = 10), Ranger™ (Group R, n = 10), and ThermoSens® (Group T, n = 10) at 440 ml/h for 60 min. All devices were set at a warming temperature of 41℃ with preheating for 10 min...
August 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28780512/repeated-administration-of-dapirolizumab-pegol-in-a-randomised-phase-i-study-is-well-tolerated-and-accompanied-by-improvements-in-several-composite-measures-of-systemic-lupus-erythematosus-disease-activity-and-changes-in-whole-blood-transcriptomic-profiles
#17
RANDOMIZED CONTROLLED TRIAL
Chris Chamberlain, Peter J Colman, Ann M Ranger, Linda C Burkly, Geoffrey I Johnston, Christian Otoul, Christian Stach, Miren Zamacona, Thomas Dörner, Murray Urowitz, Falk Hiepe
OBJECTIVES: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease associated with diffuse immune cell dysfunction. CD40-CD40 ligand (CD40L) interaction activates B cells, antigen-presenting cells and platelets. CD40L blockade might provide an innovative treatment for systemic autoimmune disorders. We investigated the safety and clinical activity of dapirolizumab pegol, a polyethylene glycol conjugated anti-CD40L Fab' fragment, in patients with SLE. METHODS: This 32-week randomised, double-blind, multicentre study (NCT01764594) evaluated repeated intravenous administration of dapirolizumab pegol in patients with SLE who were positive for/had history of antidouble stranded DNA/antinuclear antibodies and were on stable doses of immunomodulatory therapies (if applicable)...
November 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28756299/is-the-size-and-composition-of-the-paraspinal-muscles-associated-with-low-back-pain-a-systematic-review
#18
REVIEW
Tom A Ranger, Flavia M Cicuttini, Tue S Jensen, Waruna L Peiris, Sultana Monira Hussain, Jessica Fairley, Donna M Urquhart
BACKGROUND CONTEXT: Although previous studies have investigated the association between paraspinal muscle morphology and low back pain (LBP), the results are conflicting. PURPOSE: This systematic review examined the relationship between size and composition of the paraspinal muscles and LBP. STUDY DESIGN/SETTING: A systematic review was carried out. PATIENT SAMPLE: No patient sample was required. OUTCOME MEASURES: This review had no outcome measures...
July 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28715355/repeated-exposure-to-sucrose-for-procedural-pain-in-mouse-pups-leads-to-long-term-widespread-brain-alterations
#19
Sophie Tremblay, Manon Ranger, Cecil M Y Chau, Jacob Ellegood, Jason P Lerch, Liisa Holsti, Daniel Goldowitz, Ruth E Grunau
Oral sucrose is administered routinely to reduce pain of minor procedures in premature infants and is recommended as standard care in international guidelines. No human or animal studies on effects of early repeated sucrose exposure on long-term brain development have been done in the context of pain. We evaluated the effects of repeated neonatal sucrose treatment before an intervention on long-term brain structure in mouse pups. Neonatal C57Bl/6J mice (n = 109) were randomly assigned to one of 2 treatments (vehicle vs sucrose) and one of 3 interventions (handling, touch, or needle-prick)...
August 2017: Pain
https://www.readbyqxmd.com/read/28702154/a-case-report-on-late-presentation-of-occult-dural-lesions
#20
Timothy J Cochrane, Gurpreet Singh Ranger
BACKGROUND: Occult dural injuries are rare and can occur as a result of major or minor head injury. These injuries usually manifest with cerebrospinal fluid rhinorrhea alone, or with meningitis and cerebral abscess, sometimes many years after the original injury. CASE PRESENTATION: We present a case of occult dural injury with endocranial complications which occurred in a 34 year old man, with a history of head injury forty-three years ago. The patient presented with a triad of findings; meningitis, CSF rhinorrhoea and pneumocephalus...
2017: Caspian Journal of Internal Medicine
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