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https://www.readbyqxmd.com/read/29345054/isoflurane-anesthesia-in-aged-mice-and-effects-of-a1-adenosine-receptors-on-cognitive-impairment
#1
Chun-Long Zuo, Chun-Man Wang, Jin Liu, Ting Shen, Jiang-Ping Zhou, Xin-Rui Hao, Yi-Zhao Pan, Hua-Cheng Liu, Qing-Quan Lian, Han Lin
AIMS: Isoflurane may not only accelerate the process of Alzheimer's disease (AD), but increase the risk of incidence of postoperative cognitive dysfunction (POCD). However, the underlying mechanisms remain unknown. This study was designed to investigate whether isoflurane contributed to the POCD occurrence through A1 adenosine receptor (A1AR) in aged mice. METHODS: We assessed cognitive function of mice with Morris water maze (MWM) and then measured expression level of two AD biomarkers (P-tau and Aβ) and a subtype of the NMDA receptor (NR2B) in aged wild-type (WT) and homozygous A1 adenosine receptor (A1AR) knockout (KO) mice at baseline and after they were exposed to isoflurane (1...
January 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29344809/regeneration-of-functional-alveoli-by-adult-human-sox9-airway-basal-cell-transplantation
#2
Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren, Yingjie Fu, Wenbin Liu, Yufei Han, Yingchuan Wu, Yu Cheng, Ting Zhang, Wei Zuo
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying lung stem/progenitor cells with regenerative capacity and utilizing them to reconstruct functional tissue is one of the biggest hopes to reverse the damage and cure such diseases. Here we showed that a rare population of SOX9+ basal cells (BCs) located at airway epithelium rugae can regenerate adult human lung. Human SOX9+ BCs can be readily isolated by bronchoscopic brushing and indefinitely expanded in feeder-free condition...
January 17, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29344234/an-oncogenic-function-of-retinoic-acid-receptor-%C3%AE-in-the-development-of-laryngeal-squamous-cell-carcinoma
#3
Cheng-Fu Cai, Cun-Shan Liu, Han-Jing Shang-Guan, Cai-Hong Yang, Xian-Yang Luo, Dong-Yan Shen, Shu-Yu Yang
The aberrant expression of retinoic acid receptor-α (RARα) has been reported in various types of cancer. However, its association with the prognosis and development of laryngeal squamous cell carcinoma (LSCC) has not yet been determined. Therefore, the present study aimed to examine the expression and function of RARα in patients with LSCC. The expression of RARα in LSCC tissues was investigated using immunostaining. An MTT assay and flow cytometry analysis were also performed to investigate the function of RARα in the proliferation and cell cycle of LSCC cells...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343301/circulating-pcsk9-levels-and-2-hpg-are-positively-correlated-in-metabolic-diseases-in-a-chinese-han-population
#4
Wen Guo, Yingyun Gong, Yong Gu, Zhenzhen Fu, Hongqi Fan, Beibei Gao, Xiaohui Zhu, Jinxiang Fu, Yang Zhao, Min Sun, Xing Liu, Xian-Cheng Jiang, Tao Yang, Hongwen Zhou
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9), which plays a crucial role in lipoprotein metabolism, has been also regarded as an important marker for atherosclerosis. Available evidence indicated that 2-h postchallenge plasma glucose (2-hPG) could be another biomarker for atherosclerosis. However, currently the association between circulating PCSK9 and 2-hPG remains unclear. Here, we explored this potential link in a Chinese Han population. METHODS: Totally, 600 Chinese Han subjects from Nanjing district, China, were enrolled for the 75-g oral glucose tolerance test (OGTT), and they included normal glucose tolerance (NGT, n = 200), impaired glucose regulation (IGR, n = 200), and type 2 diabetes (T2DM, n = 200)...
January 17, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29343186/association-between-palliative-care-and-life-sustaining-treatments-for-patients-with-dementia-a-nationwide-5-year-cohort-study
#5
Ping-Jen Chen, Fu-Wen Liang, Chung-Han Ho, Shao-Yi Cheng, Yi-Chen Chen, Yu-Han Chen, Yueh-Chun Chen
BACKGROUND: The association between palliative care and life-sustaining treatments for patients with dementia is unclear in Asian countries. AIM: To analyse the use of palliative care and its association with aggressive treatments based on Taiwanese national data. DESIGN: A matched cohort study was conducted. The association between intervention and outcome was evaluated using conditional logistic regression analyses. SETTING/PARTICIPANTS: The source population comprised 239,633 patients with dementia diagnosed between 2002 and 2013...
January 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29341216/primary-scarring-alopecia-a-retrospective-study-of-89-patients-in-taiwan
#6
Hsing-Jou Su, An-Yu Cheng, Cheng-Han Liu, Chia-Bau Chu, Chaw-Ning Lee, Chao-Kai Hsu, Julia Yu-Yun Lee, Chao-Chun Yang
Primary scarring alopecia (PSA) is caused by irreversible damage to the hair epithelial stem cells that reside in hair follicles. There is limited published work regarding PSA amongst the Asian population. The aim of this study was to evaluate the clinical features and to characterize the subtypes of PSA in southern Taiwan. In this retrospective case series, we reviewed 89 patients with pathology-confirmed PSA. The data was collected from National Cheng Kung University Hospital between 1988 through 2016. The clinical and histological data were reviewed, and the patients were characterized into different subtypes of PSA based on the clinical features and histological findings...
January 16, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29339188/the-enhancement-of-siplk1-penetration-across-bbb-and-its-anti-glioblastoma-activity-in-vivo-by-magnet-and-transferrin-co-modified-nanoparticle
#7
Dao-Zhou Liu, Ying Cheng, Rong-Qiao Cai, Wen-Wen Wang, Han Cui, Miao Liu, Bang-le Zhang, Qi-Bing Mei, Si-Yuan Zhou
In order to enhance the penetration of small interference RNA against the polo-like kinase I (siPLK1) across BBB to treat glioblastoma (GBM), transferrin (Tf) modified magnetic nanoparticle (Tf-PEG-PLL/MNP@siPLK1) was prepared. The in vitro experiments indicated that Tf-PEG-PLL/MNP@siPLK1 enhanced the cellular uptake of siPLK1, which resulted in an increase of gene silencing effect and cytotoxicity of Tf-PEG-PLL/MNP@siPLK1 on U87 cells. Besides, Tf-PEG-PLL/MNP@siPLK1 significantly inhibited the growth of U87 glioblastoma spheroids and markedly increased the BBB penetration efficiency of siPLK1 with the application of external magnetic field in in-vitro BBB model...
January 12, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29339098/vitamin-d-and-nonalcoholic-fatty-liver-disease-bi-directional-mendelian-randomization-analysis
#8
Ningjian Wang, Chi Chen, Li Zhao, Yi Chen, Bing Han, Fangzhen Xia, Jing Cheng, Qin Li, Yingli Lu
BACKGROUND: Vitamin D deficiency is associated with nonalcoholic fatty liver disease (NAFLD) in many cross-sectional studies. However, the causality between them has not been established. We used bi-directional mendelian randomization (MR) analysis to explore the causal relationship between 25-hydroxyvitamin D [25(OH)D] and NAFLD. METHODS: 9182 participants were included from a survey in East China from 2014 to 2016. We calculated weighted genetic risk scores (GRS) for 25(OH)D concentration and NAFLD based on 25(OH)D-related and NAFLD-related single nucleotide polymorphisms...
January 9, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29337619/the-role-of-necroptosis-apoptosis-and-inflammation-in-fowl-cholera-associated-liver-injury-in-a-chicken-model
#9
Qiyu Tang, Weitian Li, Na Dai, Yiming Gao, Yu Han, Guofu Cheng, Changqin Gu
Fowl cholera resulting from infection with Pasteurella multocida causes huge economic losses in the poultry industry. Necrotic hepatitis is reported to be a significant lesion associated with fowl cholera in chickens. Clarifying the underlying molecular mechanism of hepatic injury caused by P. multocida infection is needed to develop new strategies to control fowl cholera. Pasteurella multocida Q (the standard reference strain) and P. multocida 1G1 (a clinical strain) were used to infect healthy laying hens...
December 2017: Avian Diseases
https://www.readbyqxmd.com/read/29337429/co-expression-of-orfcma-with-phb-depolymerase-phazcma-in-escherichia-coli-induces-efficient-whole-cell-biodegradation-of-polyesters
#10
Ming-Chieh Lee, En-Jung Liu, Cheng-Han Yang, Li-Jung Hsiao, Tzong-Ming Wu, Si-Yu Li
Whole-cell degradation of polyesters not only avoids the tedious process of enzyme separation, but also allows the degraded product to be reused as a carbon source. In this study, Escherichia coli BL21(DE3) harboring phaZCma , a gene encoding poly(3-hydroxybutyrate) (PHB) depolymerase from Caldimonas manganoxidans, was constructed. The extra-cellular fraction of E. coli/pPHAZ exhibited a fast PHB degradation rate where it only took 35 h to completely degrade PHB films, while C. manganoxidans took 81 h to do the same...
January 16, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29336869/long-term-average-spectra-analysis-of-voice-in-children-with-cleft-palate
#11
Zengjie Yang, Jincai Fan, Jia Tian, Liqiang Liu, Cheng Gan, Tiran Zhang, Zheng Liu, Bing Han
OBJECTIVES: The purpose of this study was to survey the spectral characteristics and to compare, using an acoustic analyzer, the objective data obtained from patients with cleft palates with the objective data of normal children using long-term average spectra (LTAS) analysis. METHODS: Participants were divided into a clinical group and a control group. All participants were asked to practice reading a sentence to become fluent. The duration of each recording was about 60 seconds...
January 12, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29336513/palladium-catalyzed-asymmetric-aminohydroxylation-of-1-3-dienes
#12
Liuzhu Gong, Hong-Cheng Shen, Yu-Feng Wu, Ying Zhang, Lian-Feng Fan, Zhi-Yong Han
A Pd(II)-catalyzed asymmetric aminohydroxylation of 1,3-dienes with N-tosyl-2-aminophenols has been developed with a chiral pyridinebis(oxazoline) ligand. The highly regioselective reaction provides a direct and efficient approach to access chiral 3,4-dihydro-2H-1,4-benzoxazines in high levels of yield and enantioselectivity (up to 96:4 e.r.). The reaction employs readily available N-tosyl-2-aminophenols as a unique aminohydroxylation reagent complementary to known asymmetric aminohydroxylation methods.
January 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29336377/pulmonary-capillary-hemangiomatosis-without-pulmonary-hypertension-an-early-stage-of-disease
#13
Wan-Jun Wang, Cheng Hong, Qian Han, Ying-Ying Gu, Nuo-Fu Zhang, Rong-Chang Chen, Shi-Yue Li, Nan-Shan Zhong, Chun-Li Liu
No abstract text is available yet for this article.
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29336169/bone-metastasis-target-redox-responsive-micell-for-the-treatment-of-lung-cancer-bone-metastasis-and-anti-bone-resorption
#14
Wei-Liang Ye, Yi-Pu Zhao, Ying Cheng, Dao-Zhou Liu, Han Cui, Miao Liu, Bang-Le Zhang, Qi-Bing Mei, Si-Yuan Zhou
In order to inhibit the growth of lung cancer bone metastasis and reduce the bone resorption at bone metastasis sites, a bone metastasis target micelle DOX@DBMs-ALN was prepared. The size and the zeta potential of DOX@DBNs-ALN were about 60 nm and -15 mV, respectively. DOX@DBMs-ALN exhibited high binding affinity with hydroxyapatite and released DOX in redox-responsive manner. DOX@DBMs-ALN was effectively up taken by A549 cells and delivered DOX to the nucleus of A549 cells, which resulted in strong cytotoxicity on A549 cells...
January 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29331094/solvent-impedes-co2-cycloaddition-on-metal-organic-frameworks
#15
Dan Shao, Jinbiao Shi, Jianling Zhang, Xiuniang Tan, Tian Luo, Xiuyan Cheng, Bingxing Zhang, Buxing Han
The catalytic performance of metal-organic frameworks (MOFs) for the synthesis of cyclic carbonate from carbon dioxide and epoxides has been explored in solvent and solvent-free conditions, respectively. It was found that MOF catalysts have significantly improved catalytic activities in solvent-free CO2 cycloaddition reactions than those in solvent. The mechanism was discussed from the competition of solvent with substrate to adhere MOF catalysts during reaction process.
January 13, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29329013/antiobesity-effect-of-lactobacillus-reuteri-263-associated-with-energy-metabolism-remodeling-of-white-adipose-tissue-in-high-energy-diet-fed-rats
#16
Li-Han Chen, Yi-Hsing Chen, Kuan-Chen Cheng, Ting-Yi Chien, Ching-Hung Chan, Shu-Ping Tsao, Hui-Yu Huang
Obesity is a serious and costly issue to the medical welfare worldwide. Probiotics have been suggested as one of the candidates to resolve the obesity-associated problems, but how they combat obesity is not fully understood. Herein, we investigated the effects of Lactobacillus reuteri 263 (L. reuteri 263) on antiobesity using four groups of Sprague-Dawley rats (n=10/group), namely, C (normal diet with vehicle treatment), HE [high-energy diet (HED) with vehicle treatment], 1X (HED with 2.1×109 CFU/kg/day of L...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29328935/evaluation-of-robustness-of-activated-sludge-using-calcium-induced-enhancement-of-respiration
#17
Zhi-Hua Li, Yuan-Mo Zhu, Jing Zhang, Cheng-Jian Yang, Tian-Yu Zhang, Han-Qing Yu
Robustness of an activated sludge system, describing uncertainty and operational risk, was evaluated using the absence or presence of calcium-induced enhancement of respiration (CaER) effect. Generally, the fast-growing system was susceptible to external environmental variations, of which the sludge exhibited significant CaER effect under normal operational conditions, while the slow growing system showed less significant CaER effect. However, sludge in both systems exhibited CaER effect under stressed conditions of decreasing temperature or ammonia shocking...
January 4, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29328457/microrna%C3%A2-34a-inhibits-liver-cancer-cell-growth-by-reprogramming-glucose-metabolism
#18
Hai-Feng Zhang, Yi-Cheng Wang, Yi-Di Han
MicroRNAs (miRs) have been proposed as minimally invasive prognostic markers for various types of cancer, including liver cancer, which is one of the most common cancers worldwide. In the present study, the expression of miR‑34a in human liver cancer tissues and cell lines was evaluated and the effects of miR‑34a on cell proliferation, invasion and glycolysis in hepatocellular carcinoma (HCC) cells were determined. The results indicated that miR‑34a was downregulated in human liver cancer tissues. Overexpression of miR‑34a significantly inhibited liver cancer cell proliferation and clone formation...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328384/forkhead-box-protein-c1-promotes-cell-proliferation-and-invasion-in-human-cervical-cancer
#19
Lu Wang, Lulu Chai, Qingchun Ji, Rongjie Cheng, Jiao Wang, Shiyu Han
Increasing evidence has demonstrated that aberrant forkhead box protein C1 (FOXC1) expression contributes to tumorigenesis in multiple types of malignant tumor. However, the clinical significance and biological roles of FOXC1 in cervical cancer remain unknown. The expression levels of FOXC1 were examined in human cervical cancer tissues and cells using reverse transcription‑quantitative polymerase chain reaction, immunohistochemistry and western blotting. Furthermore, high FOXC1 expression was significantly associated with advanced clinical stages, a high degree of malignancy and a poor outcome...
January 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328177/projected-image-correction-technology-research-on-autonomous-perception-anisotropic-surfaces
#20
Fan Yang, Cheng Han, Bao-Xing Bai, Chao Zhang
In this paper, a projection correction method is proposed for autonomous-perception depth anisotropic surfaces, in order to improve the adaptive perceptual projection of the projection equipment under different circumstances. During the parameter calibration process of a projector-camera system with low recognition precision, as well as low noise resistance at angular points, an angular-point subpixel detection algorithm based on color information guidance was proposed to effectively improve the identification precision of the angular-point detection...
January 10, 2018: Applied Optics
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