Yuan Li, Tingting Xu, Yue Zhao, Hui Zhang, Zesheng Liu, Hao Wang, Chaoying Huang, Zhihao Shu, Lixin Gao, Rongrong Xie, Tingying Jiao, Dan Zhang, Dong Zhang, Xuewu Liang, Yi Zang, Yili Sun, Hong Liu, Jia Li, Yu Zhou
Inflammatory bowel disease (IBD) is a multifactorial chronic inflammation of the intestine and has become a global public health concern. A farnesoid X receptor (FXR) was recently reported to play a key role in hepatic-intestinal circulation, intestinal metabolism, immunity, and microbial regulation, and thus, it becomes a promising therapeutic target for IBD. In this study, we identified a series of nonbile acid FXR agonists, in which 33 novel compounds were designed and synthesized by the structure-based drug design strategy from our previously identified hit compound...
March 28, 2024: Journal of Medicinal Chemistry