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Hepatitis, Inflammatory bowel disease

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https://www.readbyqxmd.com/read/28333769/the-incidence-of-low-seroimmunity-to-hepatitis-b-virus-in-children-with-inflammatory-bowel-disease
#1
Abhishek Watts, William E Bennett, Jean P Molleston, Sandeep K Gupta, Joseph M Croffie, Shamaila Waseem, Brian A McFerron, Steven J Steiner, Sanjay Kumar, Charles P Vanderpool, Emily C Hon, Molly A Bozic, Girish C Subbarao, Marian D Pfefferkorn
OBJECTIVES: Patients with inflammatory bowel disease (IBD) often receive immunosuppressive therapy which may make them vulnerable to infections such as hepatitis B. We hypothesized that hepatitis B virus (HBV) titers are low in the vaccinated pediatric IBD population. The aims of our study were to identify the incidence of lower titers of hepatitis B surface antibody (HBsAb) and determine which patient factors may be associated with lower HBsAb titers. METHODS: Patients with diagnosis of IBD, ages 5-18 years, were prospectively enrolled...
March 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28272159/outcomes-in-pediatric-autoimmune-hepatitis-and-significance-of-azathioprine-metabolites
#2
Melissa A Sheiko, Shikha S Sundaram, Kelley E Capocelli, Zhaoxing Pan, Annette M McCoy, Cara L Mack
OBJECTIVES: Autoimmune hepatitis (AIH) is a common pediatric liver disease and long-term remission is usually maintained with azathioprine (AZA). There is no consensus on the target range for AZA active metabolite 6-thioguanine (6-TGN) levels in pediatric AIH. The aim of this study was to characterize the outcomes of pediatric patients with AIH and determine correlations between AZA dosing or 6-TGN metabolite levels and biochemical remission. METHODS: A retrospective chart review was performed and data on presentation, laboratories including AZA metabolite levels, medication use and outcomes was collected...
March 7, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28271528/the-animal-naming-test-an-easy-tool-for-the-assessment-of-hepatic-encephalopathy
#3
Francesca Campagna, Sara Montagnese, Lorenzo Ridola, Marco Senzolo, Sami Schiff, Michele De Rui, Chiara Pasquale, Silvia Nardelli, Ilaria Pentassuglio, Carlo Merkel, Paolo Angeli, Oliviero Riggio, Piero Amodio
BACKGROUND AND AIMS: Screening for hepatic encephalopathy (HE) that does not cause obvious disorientation or asterixis (MHE/grade I HE) is important. We examined if the animal naming test (ANT1 ) (maximum number of animals listed in one minute) is useful in this context. METHODS: In total, 208 healthy controls, 40 controls with inflammatory bowel disease (IBD) and 327 consecutive patients with cirrhosis underwent the ANT1 . The patients were tested for MHE by the psychometric hepatic encephalopathy score (PHES), and 146 were assessed by electroencephalography (EEG); 202 patients were followed up regarding the occurrence of overt HE and death...
March 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28271269/-a%C3%A2-20-year-old-woman-with-ulcerative-colitis-and-acute-liver-failure
#4
R Forker, M Escher, E F Stange
A 20-year-old woman presented with acute exacerbation of ulcerative colitis. After treatment with infliximab, she developed a fulminant liver failure. Under supportive therapy and steroid medication, recovery of symptoms and transaminases occurred. A few case reports about hepatic side effects of anti-TNF-α antibodies in patients with inflammatory bowel disease have been published. These side effects ranged from asymptomatic increase of transaminases to fulminant liver failure necessitating transplantation...
March 7, 2017: Der Internist
https://www.readbyqxmd.com/read/28267887/enhanced-liver-fibrosis-test-predicts-transplant-free-survival-in-primary-sclerosing-cholangitis-a-multi-center-study
#5
Elisabeth M G de Vries, Martti Färkkilä, Piotr Milkiewicz, Johannes R Hov, Bertus Eksteen, Douglas Thorburn, Olivier Chazouillères, Albert Pares, Ståle Nygård, Odd Helge Gilja, Ewa Wunsch, Pietro Invernizzi, Marco Carbone, Francesca Bernuzzi, Kirsten Muri Boberg, Helge Røsjø, William Rosenberg, Ulrich H Beuers, Cyriel Y Ponsioen, Tom H Karlsen, Mette Vesterhus
BACKGROUND AND AIMS: Biomarkers reflecting disease activity and prognosis in primary sclerosing cholangitis (PSC) have not been firmly established. Enhanced Liver Fibrosis (ELF) test was previously reported to predict outcome in PSC. We aimed to validate the prognostic utility of ELF test in an independent, multicenter, retrospective PSC study population. METHODS: We collected serum samples from PSC patients from seven countries. We estimated rates of transplant-free survival by the Kaplan-Meier method, used Cox proportional hazards regression to explore the association between ELF test and clinical outcome and determined prognostic performance of ELF test by computing the area under the receiver operating characteristic (AUC-ROC) curve...
March 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28265826/intestinal-inflammation-does-not-predict-nonalcoholic-fatty-liver-disease-severity-in-inflammatory-bowel-disease-patients
#6
Rotonya M Carr, Arpan Patel, Hillary Bownik, Amanke Oranu, Caroline Kerner, Amy Praestgaard, Kimberly A Forde, K Rajender Reddy, Gary R Lichtenstein
BACKGROUND AND AIM: Nonalcoholic fatty liver disease (NAFLD) is a common cause of hepatic steatosis in patients with inflammatory bowel disease (IBD). Both metabolic syndrome (MetS) and intestinal inflammation are implicated in NAFLD pathogenesis. METHODS: We performed a retrospective cohort study of patients with IBD and NAFLD seen in our health system from January 1997 to December 2011 to examine associations between IBD severity and phenotype; MetS; and NAFLD fibrosis as estimated by the NAFLD Fibrosis Score (NFS)...
March 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28239319/prevalence-of-hepatitis-b-hepatitis-c-and-human-immunodeficiency-viral-infections-in-patients-with-inflammatory-bowel-disease-in-north-india
#7
Parnita Harsh, Vipin Gupta, Saurabh Kedia, Sawan Bopanna, Sucharita Pilli, Surendernath, Govind Kumar Makharia, Vineet Ahuja
BACKGROUND/AIMS: Patients with inflammatory bowel disease (IBD) often require immunosuppressive therapy and blood transfusions and therefore are at a high risk of contracting infections due to hepatitis B (HBV) and hepatitis C (HCV) and human immunodeficiency virus (HIV). In the present study, we assessed the prevalence of these infections in patients with IBD. METHODS: This retrospective study included 908 consecutive patients with IBD (ulcerative colitis [UC], n=581; Crohn's disease [CD], n=327) who were receiving care at a tertiary care center...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28239312/inflammatory-bowel-disease-is-no-longer-a-risk-factor-of-viral-hepatitis-infection-in-asia
#8
EDITORIAL
Eun Soo Kim
No abstract text is available yet for this article.
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28219691/hepatitis-b-reactivation-associated-with-immune-suppressive-and-biological-modifier-therapies-current-concepts-management-strategies-and-future-directions
#9
REVIEW
Rohit Loomba, T Jake Liang
Hepatitis B reactivation associated with immune suppressive and biological therapies is emerging to be an important cause of morbidity and mortality in patients with current or prior exposure to hepatitis B virus infection. The population at risk for HBV reactivation includes those who are either currently infected with HBV or have past exposure to HBV. Since curative and eradicative therapy for HBV is not currently available, there is a large reservoir of individuals at risk for HBV reactivation in the general population...
February 17, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28212760/psoriasis-and-comorbid-diseases-implications-for-management
#10
REVIEW
Junko Takeshita, Sungat Grewal, Sinéad M Langan, Nehal N Mehta, Alexis Ogdie, Abby S Van Voorhees, Joel M Gelfand
As summarized in the first article in this continuing medical education series, the currently available epidemiologic data suggest that psoriasis may be a risk factor for cardiometabolic disease. Emerging data also suggest associations between psoriasis and other comorbidities beyond psoriatic arthritis, including chronic kidney disease, inflammatory bowel disease, hepatic disease, certain malignancies, infections, and mood disorders. Recognizing the comorbid disease burden of psoriasis is essential for ensuring comprehensive care of patients with psoriasis...
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28183265/some-important-dietary-polyphenolic-compounds-an-anti-inflammatory-and-immunoregulatory-perspective
#11
Mayank Kinger, Sushil Kumar, Vinod Kumar
Inflammation plays an important role in maintaining the body's homeostasis. It repairs the damaged tissues of the body resulting from injury or infection. In addition, a diverse array of diseases like hepatitis, arthritis and colitis has been reported and described to be associated with inflammatory processes. Some autoimmune diseases like inflammatory bowel disease (IBD) emerge by the influence of numerous genes in complex environmental situations belongs to inflammation. The currently available processes for curing inflammation and related disorders facilitate the use of non steroidal anti-inflammatory drugs (NSAIDs)...
February 8, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28175296/n814-improvement-in-the-treatment-and-management-of-patients-affected-by-inflammatory-bowel-disease-hepatitis-b-and-vaccination-status
#12
F M Onidi, G Mocci, F Cabras
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172972/p486-immunization-status-of-children-and-adolescents-with-inflammatory-bowel-disease-or-autoimmune-hepatitis-in-germany
#13
L Cagol, K Frivolt, A Krahl, N Förster, E Lainka, P Gerner, D Ney, J Vermehren, S Trenkel, M Radke, S Koletzko, C Posovszky
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172948/p548-hepatitis-b-virus-reactivation-in-hepatitis-b-virus-infected-patients-with-inflammatory-bowel-disease-receiving-anti-tumor-necrosis-factor-alpha-therapy
#14
J M Lee, K-M Lee, H-S Kim, B D Ye, S J Park, S H Park, J P Im, B I Jang, D B Kim
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28160246/hypogonadotropic-hypogonadism-in-males-with-glycogen-storage-disease-type-1
#15
Evelyn M Wong, Anna Lehman, Philip Acott, Jane Gillis, Daniel L Metzger, Sandra Sirrs
BACKGROUND: Glycogen storage disease type 1 is an autosomal recessive disorder with an incidence of 1 in 100,000. Long-term complications include chronic blood glucose lability, lactic academia, short stature, osteoporosis, delayed puberty, gout, progressive renal insufficiency, systemic or pulmonary hypertension, hepatic adenomas at risk for malignant transformation, anemia, vitamin D deficiency, hyperuricemic nephrocalcinosis, inflammatory bowel syndrome (type 1b), hypertriglyceridemia, and irregular menstrual cycles...
February 4, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28147365/measurement-of-fibrosis-in-crohn-s-disease-strictures-with-imaging-and-blood-biomarkers-to-inform-clinical-decisions
#16
REVIEW
Peter D R Higgins
BACKGROUND: Distinguishing fibrosis from inflammation in an intestinal stricture in Crohn's disease is quite difficult. The absence of signs of inflammation on CT or MRI does not prove the absence of inflammation, as most strictures have a mix of fibrosis and inflammation. Identifying refractory fibrosis and distinguishing the patients who will respond to anti-inflammatory therapy from those who will require surgery are important clinical requirements, and several new technologies in imaging and serum biomarkers are being applied to this problem...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28141677/the-unique-inflammatory-bowel-disease-phenotype-of-pediatric-primary-sclerosing-cholangitis-a-single-center-study
#17
Henry Shiau, Faith D Ihekweazu, Mansi Amin, Tatiana Fofanova, Tamir Miloh, Richard Kellermayer
BACKGROUND: In adults, primary sclerosing cholangitis (PSC), a cholestatic liver disease characterized by inflammation/fibrosis of intra/extra-hepatic bile ducts, associates with a milder form of inflammatory bowel disease (IBD), particularly ulcerative colitis (UC). The pediatric PSC-IBD phenotype is less well characterized. METHODS: We performed a retrospective, single-center study examining PSC-IBD patients at Texas Children's Hospital (TCH) between 2000-2015...
January 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28130685/metabolite-monitoring-to-guide-thiopurine-therapy-in-systemic-autoimmune-diseases
#18
Aurélie Chapdelaine, Anne-Marie Mansour, Yves Troyanov, David R Williamson, Maxime Doré
6-Thioguanine nucleotide (6-TGN) is the active metabolite of thiopurine drugs azathioprine and 6-mercaptopurine. 6-Methylmercaptopurine (6-MMP) is an inactive and potentially hepatotoxic metabolite. A subgroup of patients (shunters) preferentially produce 6-MMP instead of 6-TGN, therefore displaying thiopurine resistance and risk for hepatotoxicity. Outside inflammatory bowel disease literature, few data exist regarding individualized thiopurine therapy based on metabolite monitoring. This study sought to describe metabolite monitoring in patients receiving weight-based thiopurine for systemic autoimmune diseases...
January 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28124291/gastrointestinal-and-hepatic-complications-of-immune-checkpoint-inhibitors
#19
REVIEW
Peyton Cramer, Robert S Bresalier
PURPOSE OF REVIEW: Gastrointestinal complications are very common in patients undergoing cancer treatment. Some of these complications can be life threatening and require prompt and appropriate diagnosis and treatment. The purpose of this review is to address luminal gastrointestinal and hepatic complications associated with a new class of anticancer drugs, immune checkpoint inhibitors (CPIs), and focuses on the identification, evaluation, and management of the complications associated with this class of drugs...
January 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28118178/prevalence-of-hepatitis-b-and-c-and-factors-for-infection-and-nonimmune-in-inflammatory-bowel-disease-patients-in-china
#20
Dafan Chen, Shengzheng Luo, Qiwen Ben, Lungen Lu, Xinjian Wan, Jianjiong Wu
OBJECTIVE: The aims of this study were to investigate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in inflammatory bowel disease (IBD) patients and the risk factors related to the infection and nonimmune status. METHODS: A retrospective study was carried out at two clinical centers. The prevalence of viral markers and risk factors related to HBV and HCV infection and nonimmune status were analyzed in IBD patients. Age-matched and sex-matched healthy individuals were recruited as the controls...
January 21, 2017: European Journal of Gastroenterology & Hepatology
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