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https://www.readbyqxmd.com/read/29933094/phenol-neurolysis-for-management-of-shoulder-spasticity-in-early-recovery-from-traumatic-brain-injury-a-case-report
#1
Manuel F Mas, Craig DiTommaso, Sheng Li
This case describes a 16-year-old boy who suffered a severe traumatic brain injury. The patient gradually recovered but developed debilitating spasticity mainly in left triceps muscle, abnormal positioning of shoulder girdle complex, and shoulder pain. Phenol (6%) was injected to axillary and radial nerves under guidance of electrical stimulation and ultrasound imaging at 10 weeks after initial injury. After injection, triceps spasticity and shoulder pain was immediately reduced and abnormal positions of shoulder girdle complex and elbow joint gradually returned to functional limits over 2 weeks...
June 19, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29932410/extensive-brain-infarction-and-acute-kidney-injury-in-a-young-adult-with-methanol-intoxication-a-case-report-and-review-of-the-literature
#2
George Vasquez-Rios, Hani Alkhankan, Boutros Peter Sawaya, Javier A Neyra
INTRODUCTION: Methanol intoxication is an infrequent cause of poisoning in the United Sates. It can present with prominent stroke-like features and acute kidney injury. Despite the life-threatening nature of this condition, it is poorly identified by clinicians. We aim to present a case of rapidly progressive mental decline and renal involvement, discuss a diagnostic work-up and provide a critical review on therapeutic strategies. CASE PRESENTATION: A 24-year-old patient presented to the emergency department with acute encephalopathy and diffuse muscular rigidity...
June 22, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29926353/correction-to-all-trans-retinoic-acid-ameliorates-the-early-experimental-cerebral-ischemia-reperfusion-injury-in-rats-by-inhibiting-the-loss-of-the-blood-brain-barrier-via-the-jnk-p38mapk-signaling-pathway
#3
Minghang Li, Xiaocui Tian, Ruidi An, Mei Yang, Qian Zhang, Fei Xiang, Hailin Liu, Yuchun Wang, Lu Xu, Zhi Dong
The original version of this article unfortunately contained a mistake. The affiliation of the author Lu Xu has been submitted and published incorrectly and has been corrected with the erratum.
June 20, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29920690/barriers-and-enablers-to-aligning-rehabilitation-goals-to-patient-life-roles-following-acquired-brain-injury
#4
Danielle Sansonetti, Rebecca J Nicks, Carolyn Unsworth
BACKGROUND/AIM: Life roles are integral to occupational therapy practice. Goal setting is a method of establishing priorities to measure outcomes. While acquired brain injury can impact a person's ability to fulfil meaningful life roles, the alignment of goals set in rehabilitation to life roles, is unclear. This study aimed to (i) explore the alignment of goals with life roles for people with an acquired brain injury participating in inpatient rehabilitation; and (ii) identify barriers and enablers to life role discussions within a patient-directed goal setting framework...
June 19, 2018: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/29907853/monitoring-cerebral-oxygenation-of-the-immature-brain-a-neuroprotective-strategy
#5
REVIEW
Frank van Bel, Jonathan P Mintzer
Monitoring of cerebral oxygenation (rScO2 ) with near-infrared spectroscopy (NIRS) is a feasible noninvasive bedside technique in the NICU. This review discusses the possible neuroprotective role of "pattern recognition" of NIRS-derived rScO2 in preterm neonates with regard to the prevention of severe intraventricular hemorrhage and hypoxia/hyperoxia-related white matter injury. This neuroprotective role of rScO2 monitoring is discussed as a modality to aid in the early detection of cerebral oxygenation conditions predisposing to these complications...
June 15, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29905889/thioredoxin-interacting-protein-mediates-mitochondrion-dependent-apoptosis-in-early-brain-injury-after-subarachnoid-hemorrhage
#6
Yidan Liang, Xudong Che, Qing Zhao, Rami Darwazeh, Hongxia Zhang, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Wang Qin, Liu Liu, Zhaohui He
Early brain injury (EBI) was reported to be the primary cause of high mortality and poor outcomes in subarachnoid hemorrhage (SAH) patients, and apoptosis is regarded as the most important physiopathologic mechanism during EBI. Recently, our team found that thioredoxin-interacting protein (TXNIP) links endoplasmic reticulum stress (ER stress) to neuronal apoptosis and aggravates EBI. However, the other underlying mechanisms remain unknown. Mitochondria are considered to be the central points in integrating apoptotic cell death...
June 15, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29904350/unique-contribution-of-haptoglobin-and-haptoglobin-genotype-in-aneurysmal-subarachnoid-hemorrhage
#7
REVIEW
Spiros L Blackburn, Peeyush T Kumar, Devin McBride, Hussein A Zeineddine, Jenna Leclerc, H Alex Choi, Pramod K Dash, James Grotta, Jaroslaw Aronowski, Jessica C Cardenas, Sylvain Doré
Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological deficits. Much of this is related to the effects of blood in the subarachnoid space which induces an inflammatory cascade with numerous downstream consequences. Recent clinical trials have not been able to reduce the toxic effects of free hemoglobin or improve clinical outcome. One reason for this may be the inability to identify patients at high risk for neurologic decline. Recently, haptoglobin genotype has been identified as a pertinent factor in diabetes, sickle cell, and cardiovascular disease, with the Hp 2-2 genotype contributing to increased complications...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29903453/topography-of-the-cerebellum-in-relation-to-social-brain-regions-and-emotions
#8
Maria Leggio, Giusy Olivito
In the last few decades, an increasing number of studies have focused on better characterizing the cerebellar functions beyond motor control, including emotional and social domains. Anatomic and functional evidence strongly contributes to delineating the cerebellar functional subdivisions and their integration with cerebral functional networks strictly related to emotional regulation and social functioning, thus suggesting a model of cerebellar organization that resembles that of the cerebral cortex. Overcoming the traditional segregation of cerebrocerebellar networks in sensorimotor/cognitive functional modules, during emotional/social processes, the cerebellar activity reflects a domain-specific mentalizing functionality that is strongly connected with corresponding mentalizing networks in the cerebrum...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29901788/somatotopic-mapping-of-the-developing-sensorimotor-cortex-in-the-preterm-human-brain
#9
S Dall'Orso, J Steinweg, A G Allievi, A D Edwards, E Burdet, T Arichi
In the mature mammalian brain, the primary somatosensory and motor cortices are known to be spatially organized such that neural activity relating to specific body parts can be somatopically mapped onto an anatomical "homunculus". This organization creates an internal body representation which is fundamental for precise motor control, spatial awareness and social interaction. Although it is unknown when this organization develops in humans, animal studies suggest that it may emerge even before the time of normal birth...
July 1, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29901746/brain-mri-fiber-tracking-reveals-white-matter-alterations-in-hypertensive-patients-without-damage-at-conventional-neuroimaging
#10
Lorenzo Carnevale, Valentina D'Angelosante, Alessandro Landolfi, Giovanni Grillea, Giulio Selvetella, Marianna Storto, Giuseppe Lembo, Daniela Carnevale
Aims: Hypertension is one of the main risk factor for dementia. The subtle damage provoked by chronic high blood pressure in the brain is usually evidenced by conventional magnetic resonance imaging (MRI), in terms of white matter (WM) hyperintensities or cerebral atrophy. However, it is clear that by the time brain damage is visible, it may be too late hampering neurodegeneration. Aim of this study was to characterize a signature of early brain damage induced by hypertension, before the neurodegenerative injury manifests...
June 12, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29898033/interleukin-6-contributes-to-myocardial-damage-in-pregnant-rats-with-reduced-uterine-perfusion-pressure
#11
Lan Ding, Chuanming Bai, Ying Liu
Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusion pressure (RUPP) to generate a rat model of preeclampsia for the evaluation of myocardial damage in late-gestation rats. The expressions of cardiac injury markers were analyzed by immunohistochemistry and ELISA...
June 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29897002/early-amplitude-integrated-electroencephalogram-as-a-predictor-of-brain-injury-in-newborns-with-very-low-birth-weight-a-cohort-study
#12
Luiza V S Magalhães, Maria Isabel B Winckler, José Augusto Bragatti, Renato S Procianoy, Rita C Silveira
PURPOSE: To evaluate the relationship between abnormal early amplitude integrated electroencephalography (EEG) and severe lesions in imaging tests performed during the neonatal period in very low birth weight infants. METHODS: An amplitude-integrated EEG was performed in 70 patients with a mean birth weight of 1226 g during the first 48 hours of life. Severe lesions on magnetic resonance imaging (MRI) or ultrasonography (US) during the neonatal period were considered as adverse conditions...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29896457/ankylosing-neurogenic-myositis-ossificans-of-the-hip-a-case-series-and-review-of-literature
#13
Byung-Ho Yoon, In Keun Park, Yerl-Bo Sung
Purpose: Neurogenic myositis ossificans (NMO) in patients with traumatic spinal cord or brain injuries can cause severe joint ankylosis or compromise neurovascularture. The purpose of this study was to evaluate the clinical and radiological outcomes of and review considerations relevant to surgical resection of NMO of the hip joint. Materials and Methods: Six patients (9 hips) underwent periarticular NMO resection between 2015 and 2017. The medical records of these patients were retrospectively reviewed...
June 2018: Hip & Pelvis
https://www.readbyqxmd.com/read/29895321/neural-stem-cell-therapy-for-subacute-and-chronic-ischemic-stroke
#14
REVIEW
Austin C Boese, Quan-Son Eric Le, Dylan Pham, Milton H Hamblin, Jean-Pyo Lee
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading cause of death and disability. Clinically, extensive injury from ischemic stroke results from ischemia-reperfusion (IR), which is accompanied by inflammation, blood-brain barrier (BBB) damage, neural cell death, and extensive tissue loss. Tissue plasminogen activator (tPA) is still the only US Food and Drug Administration-approved clot-lysing agent...
June 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29895273/prevalence-of-acute-stress-disorder-among-road-traffic-accident-survivors-a-meta-analysis
#15
Wenjie Dai, Aizhong Liu, Atipatsa C Kaminga, Jing Deng, Zhiwei Lai, Jianzhou Yang, Shi Wu Wen
BACKGROUND: Road traffic accident (RTA), an unexpected traumatic event, may not only lead to death and serious physical injuries, but also could put survivors at an increased risk for a wide range of psychiatric disorders, particularly acute stress disorder (ASD). Early assessment of trauma-related psychological responses is important because acute trauma responses in the early post-traumatic period are among the robust predictors of long-term mental health problems. However, estimates of the prevalence of ASD among RTA survivors varied considerably across studies...
June 13, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29894755/activation-of-bradykinin-b2-receptor-induced-the-inflammatory-responses-of-cytosolic-phospholipase-a-2-after-the-early-traumatic-brain-injury
#16
Honglu Chao, Yinlong Liu, Chao Lin, Xiupeng Xu, Zheng Li, Zhongyuan Bao, Liang Fan, Chao Tao, Lin Zhao, Yan Liu, Xiaoming Wang, Yongping You, Ning Liu, Jing Ji
Phospholipase A2 is a known aggravator of inflammation and deteriorates neurological outcomes after traumatic brain injury (TBI), however the exact inflammatory mechanisms remain unknown. This study investigated the role of bradykinin and its receptor, which are known initial mediators within inflammation activation, as well as the mechanisms of the cytosolic phospholipase A2 (cPLA2 )-related inflammatory responses after TBI. We found that cPLA2 and bradykinin B2 receptor were upregulated after a TBI. Rats treated with the bradykinin B2 receptor inhibitor LF 16-0687 exhibited significantly less cPLA2 expression and related inflammatory responses in the brain cortex after sustaining a controlled cortical impact (CCI) injury...
June 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29894208/does-a-regular-wessex-head-injury-matrix-assessment-identify-early-signs-of-infections-in-people-with-prolonged-disorders-of-consciousness
#17
Samira Kashinath Dhamapurkar, Barbara A Wilson, Anita Rose, Gerhard Florschutz, Peter Watson, Agnes Shiel
BACKGROUND & OBJECTIVE: Patients with brain injury are at high risk for infections. Although infection and cognitive deterioration are established for people with dementia, this has not been shown for patients with a prolonged disorder of consciousness (PDOC). This study determines whether regular Wessex Head Injury Matrix (WHIM) assessments can identify early signs of infections in patients with PDOC. METHOD: Retrospective and prospective approaches were used to assess the WHIM scores of patients with a PDOC (N = 21 in the retrospective study and 22 in the prospective study)...
June 12, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29893758/early-and-rapid-detection-of-uchl1-in-the-serum-of-brain-trauma-patients-a-novel-gold-nanoparticle-based-method-for-diagnosing-the-severity-of-brain-injury
#18
Gyaninder Pal Singh, Richa Nigam, Gaurav Singh Tomar, Mohan Monisha, Sanjeev Kumar Bhoi, Arulselvi S, Kangana Sengar, Deepa Akula, Prashanth Panta, Roy Anindya
The clinical diagnosis of traumatic brain injury (TBI) is based on neurological examination and neuro-imaging tools such as CT scanning and MRI. However, neurological examination at times may be confounded by consumption of alcohol or drugs and neuroimaging facilities may not be available at all centers. Human ubiquitin C-terminal hydrolase (UCHL1) is a well-accepted serum biomarker for severe TBI and can be used to detect the severity of a head injury. A reliable, rapid, cost effective, bedside and easy to perform method for the detection of UCHL1 is a pre-requisite for wide clinical applications of UCHL1 as a TBI biomarker...
June 12, 2018: Analyst
https://www.readbyqxmd.com/read/29891065/cerebellar-mutism-syndrome
#19
Coriene Catsman-Berrevoets, Zoltan Patay
Cerebellar mutism most commonly, but not exclusively, develops in children after surgery for midline cerebellar or intraventricular tumors in the posterior fossa, typically medulloblastoma. Cerebellar mutism syndrome (CMS) comprises a complex set of neurologic and neurocognitive signs and symptoms, the cardinal and central component of which is an initially profound but usually reversible speech disorder. As such, CMS is currently recognized as an extreme form of the so-called cerebellar cognitive affective syndrome (Schmahmann syndrome)...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29890324/white-matter-injury-in-term-neonates-with-congenital-heart-diseases-topology-comparison-with-preterm-newborns
#20
REVIEW
Ting Guo, Vann Chau, Shabnam Peyvandi, Beatrice Latal, Patrick S McQuillen, Walter Knirsch, Anne Synnes, Maria Feldmann, Nadja Naef, M Mallar Chakravarty, Alessandra De Petrillo, Emma G Duerden, A James Barkovich, Steven P Miller
BACKGROUND: Neonates with congenital heart disease (CHD) are at high risk of punctate white matter injury (WMI) and impaired brain development. We hypothesized that WMI in CHD neonates occurs in a characteristic distribution that shares topology with preterm WMI and that lower birth gestational age (GA) is associated with larger WMI volume. OBJECTIVE: (1) To quantitatively assess the volume and location of WMI in CHD neonates across three centres. (2) To compare the volume and spatial distribution of WMI between term CHD neonates and preterm neonates using lesion mapping...
June 8, 2018: NeuroImage
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