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https://www.readbyqxmd.com/read/29684853/naringenin-improve-hepatitis-c-virus-infection-induced-insulin-resistance-by-increase-pten-expression-via-p53-dependent-manner
#1
Benli Jia, Dongsheng Yu, Gang Yu, Yunsheng Cheng, Yang Wang, Xiaoqiang Yi, Xiaoping Li, Yong Wang
Hepatitis C virus (HCV) infection may finally lead to hepatocellular carcinoma (HCC), and also associated with insulin resistance (IR). Naringenin (NGEN), a flavonoid found in grapefruit, has anti-virus, anti-inflammation and insulin sensitization effects. In the present study we examined the effects of NGEN on HCV core protein (HCVCP) infection induced IR and investigated the mechanism involved. We found that NGEN ameliorated IR and glucose tolerance in HCVCP infected mice by increase the phosphorylation of Akt at both Ser473 and Thr308 site, and also inhibited the inflammation cytokine production and T-cell immune response...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684791/the-role-of-promyelocytic-leukemia-protein-in-steatosis-associated-hepatic-tumors-related-to-chronic-hepatitis-b-virus-infection
#2
Yih-Lin Chung, Mei-Ling Wu
The persistence of hepatitis B surface antigen (HBsAg) is a risk factor for the development of steatosis-associated tumors in chronic hepatitis B virus (HBV) infection, yet little is known about the metabolic link with this factor. We correlated HBV-related pathogenesis in genetically engineered mice and human carriers with metabolic proteomics and lipogenic gene expression profiles. The immunohistochemistry showed that the promyelocytic leukemia protein (PML, a tumor suppressor involved in genome maintenance and fatty acid oxidation), being inversely influenced by the dynamic HBsAg levels from acute phase to seroclearance, appeared as a lipo-metabolic switch linking HBsAg-induced steatosis (lipogenesis) to HBsAg-lost fat-burning hepatocarcinogenesis (lipolysis)...
April 20, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29684320/initial-evaluation-of-universal-immunization-with-a-single-dose-against-hepatitis-a-virus-in-central-brazil
#3
Wagner Izidoro de Brito, Eduardo Rodrigues Alves-Junior, Rode Martinho de Oliveira, Francisco José Dutra Souto
Vaccination against the hepatitis A virus (HAV) administered in two doses has been used effectively in universal child immunization programs in several countries. A single-dose vaccination was adopted in some low-income countries in an attempt to reduce costs without losing effectiveness. In 2014, single-dose universal vaccination was introduced in Brazil for children aged two years. Since such strategy is still not universally accepted, its efficacy should be compared to the two-dose strategy. To assess the humoral response after the single-dose HAV vaccination schedule, a cross-sectional study was conducted in Primavera do Leste, in Mato Grosso state, Central Brazil, including 265 children vaccinated through the National Immunization Program...
April 20, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29683945/ebv-related-cold-agglutinin-disease-presenting-with-conjugated-hyperbilirubinemia-a-pediatric-case-report-and-mini-review
#4
Elpis Mantadakis, Eleftherios Chatzimichael, Eftychia Kontekaki, Maria Panopoulou, Georges Martinis, Aggelos Tsalkidis
Hemolytic anemia occurs in only 1% to 3% of hospitalized patients with infectious mononucleosis. The authors describe an 8-year-old girl without cervical lymphadenopathy or splenomegaly, who presented with conjugated hyperbilirubinemia and was diagnosed with cold agglutinin disease caused by an immunoglobulin M autoantibody with anti-i specificity. Acute Epstein-Barr virus infection was confirmed by serological and molecular methods. She recovered uneventfully after a 3-week course of methylprednisolone. Epstein-Barr virus infection should be considered in any case of hemolytic anemia associated with hepatic dysfunction, especially when direct antiglobulin test is positive for C3d...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683413/increased-circulating-follicular-regulatory-t-like-cells-may-play-a-critical-role-in-chronic-hepatitis-b-virus-infection-and-disease-progression
#5
Xiaojuan Wu, Zhenzhen Su, Bei Cai, Lin Yan, Yamei Li, Weihua Feng, Lanlan Wang
Follicular helper T cells (TFH) and follicular regulatory T cells (TFR), subsets of T cells, co-regulate the reactions of germinal center (GC) B cells. TFH provide help to the GC response, while the TFR suppress those processes. Nevertheless, the role of circulating TFR (cTFR) and circulating TFH (cTFH) in chronic hepatitis B virus (HBV) infection remains limited. Twenty healthy controls (HCs), 24 patients with chronic hepatitis B (CHB), 23 with HBV-related liver cirrhosis (LC), and 18 with HBV-related hepatocellular carcinoma were enrolled in our study between October 2015 and September 2016...
April 23, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29682899/generalization-and-representativeness-of-phase-iii-immune-checkpoint-blockade-trials-in-non-small-cell-lung-cancer
#6
Shin Hye Yoo, Bhumsuk Keam, Miso Kim, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo
BACKGROUND: Strict eligibility criteria for patient enrollment in phase III trials raise questions regarding generalization to ineligible patients. We evaluated whether pivotal phase III trials of immune checkpoint blockades (ICBs) represent the overall population of non-small cell lung cancer (NSCLC) patients. METHODS: We reviewed the inclusion and exclusion criteria of three phase III trials (CheckMate057, CheckMate017, and KEYNOTE-010). Stage IIIB or IV NSCLC patients diagnosed from 2011 to 2013 at Seoul National University Hospital (cohort 1) were reviewed...
April 22, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29682622/risk-of-hepatocellular-carcinoma-for-patients-treated-with-direct-acting-antivirals-steps-after-hepatitis-c-virus-eradication-to-achieve-elimination
#7
EDITORIAL
Mei-Hsuan Lee
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682590/hepatitis-b-vaccination-induced-tnf-%C3%AE-and-il-2-producing-t-cell-responses-in-hiv-healthy-individuals-higher-than-in-hiv-individuals-who-received-the-same-vaccination-regimen
#8
Kriangkrai Chawansuntati, Kanokporn Chaiklang, Romanee Chaiwarith, Jutarat Praparattanapan, Khuanchai Supparatpinyo, Jiraprapa Wipasa
We investigated cytokine production and expression of degranulation marker CD107a after different strategies of hepatitis B virus (HBV) vaccination in human immunodeficiency virus-infected individuals, which were three doses of 20  μ g (standard dose group), four doses of 20  μ g (four doses group), or four doses of 40  μ g (four double doses group), compared to standard dose vaccination in healthy controls. PBMCs collected at different time points were stimulated in vitro with recombinant hepatitis B surface antigen and analyzed by flow cytometry...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29682437/adult-onset-minimal-change-disease-with-iga-nephropathy-and-hepatitis-c
#9
Waliul Chowdhury, Tahira Sabeen Saleem, Muhammad Uzair Lodhi, Intekhab Askari Syed, Hafiz Imran Iqbal, Mustafa Rahim
Minimal change disease (MCD) is one of the most common causes of nephrotic syndrome in children, leading to heavy proteinuria and edema. However, it is not as common in adults. Adult-onset minimal change disease with IgA nephropathy is rare. The initial presentation of heavy proteinuria and edema with effacement of podocytes on electron microscopy (EM) should lead the physician to suspect minimal change disease regardless of age. We present a 44-year-old male patient with a history of hepatitis C virus (HCV) who presented with sudden onset of lower extremity edema and 6...
February 19, 2018: Curēus
https://www.readbyqxmd.com/read/29682306/anti-m%C3%A3-llerian-hormone-levels-are-reduced-in-women-living-with-human-immunodeficiency-virus-compared-to-control-women-a-case-control-study-from-copenhagen-denmark
#10
EDITORIAL
Maria Wessman, Anne-Sofie Korsholm, Janne Gasseholm Bentzen, Anders Nyboe Andersen, Magnus Glindvad Ahlström, Terese Lea Katzenstein, Nina Weis
Objectives: Anti-müllerian hormone (AMH) is a marker of ovarian reserve. The purpose of this study was to compare AMH in women living with HIV with an age-matched control group of HIV-uninfected women, and to identify possible variables associated with decreasing AMH levels in women living with HIV. Methods: AMH was measured in frozen EDTA samples from 84 white women living with HIV, aged 20 -40 years, with fully suppressed HIV RNA viral loads for at least 6 months and no hepatitis B or C virus co-infection...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29682303/heterogeneity-in-hepatitis-c-treatment-prescribing-and-uptake-in-australia-a-geospatial-analysis-of-a-year-of-unrestricted-treatment-access
#11
EDITORIAL
Nick Scott, Samuel W Hainsworth, Rachel Sacks-Davis, Alisa Pedrana, Joseph Doyle, Amanda Wade, Margaret Hellard
Background and aim: Direct-acting antiviral (DAA) treatments became available for all people living with hepatitis C virus (HCV) in Australia in March 2016. We assess variations in treatment rates and prescribing patterns across Australia's 338 Statistical Area 3 (SA3) geographical units. Methods: Geocoded DAA treatment initiation data were analysed for the period 1 March 2016 to 30 June 2017. Regression models tested associations between the population demographics and healthcare service coverage of geographical areas and (a) their treatment rates; and (b) the proportion of prescriptions written by specialists compared to non-specialists...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29682246/distribution-of-hepatitis-c-virus-genotypes-in-patients-with-major-%C3%AE-thalassemia-in-mashhad-northeast-iran
#12
Sanaz Ahmadi-Ghezeldasht, Zahra Badiei, Hamid Reza Sima, Mohammad Reza Hedayati-Moghaddam, Meysam Habibi, Mohsen Khamooshi, Ahmad Azimi
BACKGROUND Hepatitis C virus (HCV) is considered to be the major cause of post-transfusion hepatitis in patients with thalassemia. We aimed to determine the HCV prevalence, genotypes, and viral load among patients with major β-thalassemia in Mashhad, Iran. METHODS Medical records of all 550 patients with major β-thalassemia who referred to ThalassemiaHemophilia Center of Mashhad (Sarvar Clinic) were reviewed from October to November 2011. Plasma samples of the patients were tested for the presence of anti-HCV antibodies by enzyme linked immunosorbent assay...
January 2018: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29682171/a-novel-occludin-targeting-monoclonal-antibody-prevents-hepatitis-c-virus-infection-in-vitro
#13
Ken Okai, Naoki Ichikawa-Tomikawa, Akira C Saito, Tetsuya Watabe, Kotaro Sugimoto, Daiki Fujita, Chikako Ono, Takasuke Fukuhara, Yoshiharu Matsuura, Hiromasa Ohira, Hideki Chiba
Since hepatitis C virus (HCV) is thought to enter into host hepatocytes using the same cellular pathways regardless of the genotypes, the host factors are promising targets to prevent and treat HCV infection. Human occludin (hOCLN) is one representative entry factor, and its second extracellular loop (EC2) contributes to the species selectivity of HCV-susceptibility. However, the exact function of hOCLN during HCV entry remains unknown, and no hOCLN-targeting antibodies or synthetic drugs that prevent and treat HCV infection have yet been developed...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681484/design-synthesis-and-structure-activity-relationships-of-novel-imidazo-4-5-c-pyridine-derivatives-as-potent-non-nucleoside-inhibitors-of-hepatitis-c-virus-ns5b
#14
Moyi Liu, Qiaoling Xu, Su Guo, Ruixi Zuo, Yue Hong, Yong Luo, Yingxiu Li, Ping Gong, Yajing Liu
The hepatitis C virus (HCV) NS5B polymerase is an attractive target for the development of novel and selective inhibitors of HCV replication. In this paper, the design, synthesis, and preliminary SAR studies of novel inhibitors of HCV NS5B polymerase based on the structure of tegobuvir have been described. The efforts to optimize the antiviral potency and reduce the treatment side effects with respect to genotype 1b resulted in the discovery of compound 3, which exhibited an EC50 of 1.163 nM and a CC50 >200 nM in a cell-based HCV replicon system assay...
April 16, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29681166/direct-acting-antivirals-to-prevent-vertical-transmission-of-viral-hepatitis-c-when-is-the-optimal-time-to-treat
#15
Leigh Cervino, Lauren M Hynicka
OBJECTIVE: To describe the most current evidence for the use of direct-acting antivirals (DAAs) to treat hepatitis C along the pregnancy-pediatric continuum in the United States. DATA SOURCES: The MEDLINE/PubMed databases were searched (January 1995 to February 2018) for articles in English using the terms: hepatitis C, vertical transmission, pregnancy, pediatrics, ribavirin, interferon, direct acting antivirals, daclatasvir, dasabuvir, elbasvir, glecaprevir, grazoprevir, ledipasvir, ombitasvir, paritaprevir, pibrentasvir, simeprevir, sofosbuvir, and velpatasvir...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29681153/the-discovery-of-mk-6169-a-potent-pan-genotype-hepatitis-c-virus-ns5a-inhibitor-with-optimized-activity-against-common-resistance-associated-substitutions
#16
Wensheng Yu, Ling Tong, Oleg Selyutin, Lei Chen, Bin Hu, Bin Zhong, Jinglai Hao, Tao Ji, Shuai Zan, Jingjun Yin, Rebecca Tamra Ruck, Stephanie Curry, Patricia McMonagle, Sony Agrawal, Laura Rokosz, Donna Carr, Paul Ingravallo, Karin Bystol, Frederick Lahser, Rong Liu, Shiying Chen, Kung-I Feng, Mark Cartwright, Ernest Asante-Appiah, Joseph A Kozlowski
We describe the discovery of MK-6169, a potent and pan-genotype HCV NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal carbon region of elbasvir lead to the discovery of a series of compounds with substantially improved potency against common resistance-associated substitutions in the major genotypes, as well as good pharmacokinetics in both rat and dog. Through further optimization of key leads from this effort, MK-6169 (21) was discovered as a pre-clinical candidate for further development...
April 21, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29680694/hepatitis-e-virus-in-lettuce-and-water-samples-a-method-comparison-study
#17
Walter Randazzo, Andrea Vásquez-García, Maria A Bracho, María Jesús Alcaraz, Rosa Aznar, Gloria Sánchez
The hepatitis E virus (HEV), which is an increasing cause of acute viral hepatitis in Europe, is a zoonotic virus that is mainly transmitted through contaminated water, consumption of raw or undercooked meat from pigs or wild boar, blood transfusion, and organ transplantation. Although the role of HEV transmission through contaminated produce has not been confirmed, the presence of HEV has been reported in irrigation waters and in vegetables. The present study used a World Health Organization (WHO) international standard and clinical samples to evaluate the performance characteristics of three RT-qPCR assays for detection and quantification of HEV...
April 4, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29680499/corrigendum-to-hepatitis-c-virus-drug-resistance-associated-substitutions-and-their-clinical-relevance-update-2018-drug-resist-updates-37-march-2018-17-39
#18
Maria C Sorbo, Valeria Cento, Velia C Di Maio, Anita Y M Howe, Federico Garcia, Carlo F Perno, Francesca Ceccherini-Silberstein
No abstract text is available yet for this article.
April 18, 2018: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/29680461/elimination-of-hepatitis-c-virus-in-spain-a-pending-challenge
#19
Juan Berenguer
No abstract text is available yet for this article.
April 18, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29679811/hepatitis-c-care-continuum-and-associated-barriers-among-people-who-inject-drugs-in-chennai-india
#20
Eshan U Patel, Sunil S Solomon, Allison M Mcfall, Aylur K Srikrishnan, Amrose Pradeep, Paneerselvam Nandagopal, Oliver Laeyendecker, Aaron A R Tobian, David L Thomas, Mark S Sulkowski, M Suresh Kumar, Shruti H Mehta
BACKGROUND: Little is known regarding barriers to hepatitis C virus (HCV) treatment among people who inject drugs (PWID) in low-resource settings, particularly in the era of direct-acting antiviral therapies. METHODS: Between March, 2015-August, 2016, a cross-sectional survey was administered to community-based PWID in Chennai, India to examine the HCV care continuum and associated barriers. Adjusted prevalence ratios (APR) were estimated by multivariable Poisson regression with robust variance...
April 18, 2018: International Journal on Drug Policy
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