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sepsis induced cardiomyopathy

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https://www.readbyqxmd.com/read/29655602/overexpression-of-ctrp3-protects-against-sepsis-induced-myocardial-dysfunction-in-mice
#1
Wen-Ying Wei, Zhen-Guo Ma, Ning Zhang, Si-Chi Xu, Yu-Pei Yuan, Xiao-Feng Zeng, Qi-Zhu Tang
C1q/tumor necrosis factor-related protein-3 (CTRP3) shows striking homologies of genomic structure to the adiponectin. In this study, we aimed to investigate the protective role of CTRP3 against sepsis-induced cardiomyopathy. Here, we overexpressed CTRP3 in myocardium by direct intramyocardial injection and constructed a model of lipopolysaccharide (LPS)-induced sepsis in mice. Our results demonstrated that cardiac-specific overexpression of CTRP3 remarkably attenuated myocardial dysfunction and increased the phosphorylation level of AMPKα during LPS-induced sepsis...
April 12, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29616016/heparan-sulfate-induces-necroptosis-in-murine-cardiomyocytes-a-medical-in-silico-approach-combining-in-vitro-experiments-and-machine-learning
#2
Elisabeth Zechendorf, Phillip Vaßen, Jieyi Zhang, Ahmed Hallawa, Antons Martincuks, Oliver Krenkel, Gerhard Müller-Newen, Tobias Schuerholz, Tim-Philipp Simon, Gernot Marx, Gerd Ascheid, Anke Schmeink, Guido Dartmann, Christoph Thiemermann, Lukas Martin
Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis are linked to trauma- or sepsis-associated cardiomyopathy. However, the underling causative factors are still debatable. Heparan sulfate (HS) fragments belong to the class of danger/damage-associated molecular patterns liberated from endothelial-bound proteoglycans by heparanase during tissue injury associated with trauma or sepsis. We hypothesized that HS induces apoptosis or necroptosis in murine cardiomyocytes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29615637/%C3%AE-2a-adrenergic-blockade-attenuates-septic-cardiomyopathy-by-increasing-cardiac-norepinephrine-concentration-and-inhibiting-cardiac-endothelial-activation
#3
Xiaohui Yu, Yuan Wang, Duomeng Yang, Xiangxu Tang, Hongmei Li, Xiuxiu Lv, Renbin Qi, Chaofeng Hu, Daxiang Lu, Ben Lv, Huadong Wang
Cardiomyopathy is a common complication associated with increased mortality in sepsis, but lacks specific therapy. Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α2A -adrenergic receptor (AR) blockade on septic cardiomyopathy. CLP-induced septic rats were treated with BRL44408 (α2A -AR antagonist), prazosin (α1 -AR antagonist) and/or reserpine. CLP-induced cardiomyopathy, indicated by reduced dP/dt and increased cardiac troponin I phosphorylation, was attenuated by BRL44408, this was associated with reduced cardiac TNF-α and endothelial VCAM-1 expression, cardiomyocyte apoptosis and related signal molecule phosphorylation...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29595686/risk-factors-and-outcomes-of-sepsis-induced-myocardial-dysfunction-and-stress-induced-cardiomyopathy-in-sepsis-or-septic-shock-a-comparative-retrospective-study
#4
COMPARATIVE STUDY
Han Saem Jeong, Tae Hyub Lee, Cho Hee Bang, Jong-Ho Kim, Soon Jun Hong
While both sepsis-induced myocardial dysfunction (SIMD) and stress-induced cardiomyopathy (SICMP) are common in patients with sepsis, the pathogenesis of the 2 diseases is different, and they require different treatment strategies. Thus, we aimed to investigate risk factors and outcomes between the 2 diseases.This retrospective study enrolled patients diagnosed with sepsis or septic shock, admitted to intensive care unit via emergency department in Korea University Anam Hospital, and who underwent transthoracic echocardiography within the first 24 hours of admission...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29402373/-role-of-mitochondrial-dysfunction-in-the-pathogenesis-of-septic-cardiomyopathy
#5
Xiang Fang, Jinquan Wang
The incidence and mortality of septic cardiomyopathy were high, which is the common cause of death in the patients with sepsis. The pathogenesis of sepsis induced myocardial injury is still unclear. The mitochondrial dysfunction of myocardial cells plays a very important role in the pathophysiological mechanism. This review attempts to introduce the mitochondrial damage of cardiomyocyte from the regulation of mitochondrial energy metabolism, the mechanism of mitochondrial damage, the role of aquaporin and the adjustment of mitochondrial dynamic, in order to provide help for the early prevention of septic cardiomyopathy...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29351144/cardiac-dysfunction-in-critical-illness
#6
Allison Dalton, Sajid Shahul
PURPOSE OF REVIEW: Sepsis and septic shock are prevalent conditions that are likely to increase in prevalence in the future. Given the high mortality and morbidity associated with sepsis and sepsis-induced cardiac dysfunction, we must continue to make advances in knowledge of the complex physiologic interactions and how we may target specific mediators for potential therapeutic options in the future. RECENT FINDINGS: Multiple biomarkers have been discovered, which when assayed in sepsis-induced cardiomyopathy predict morbidity and mortality...
April 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29276594/prolonged-circulatory-support-with-an-impella-assist-device-in-the-management-of-cardiogenic-shock-associated-with-takotsubo-syndrome-severe-sepsis-and-acute-respiratory-distress-syndrome
#7
Edward D Foley, Ricardo Diaz, Manuel R Castresana
Severe sepsis has been known to trigger for takotsubo syndrome which is associated with profound physical or emotional stress. Severe sepsis is also associated with sepsis-induced cardiomyopathy, a reversible myocardial depression. We report a case in which a patient with takotsubo syndrome, cardiogenic shock, severe sepsis, and adult respiratory distress syndrome was managed with an Impella Cardiac Power circulatory support device for 108 h (4.5 days) because of sustained hemodynamic compromise. To the best of our knowledge, this represents the longest reported use of the Impella Cardiac Power device for the management of cardiogenic shock in a patient with takotsubo syndrome and severe sepsis...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29226955/stem-cells-rescue-cardiomyopathy-induced-by-p-gingivalis-lps-via-mir-181b
#8
Tung-Sheng Chen, Sarnai Battsengel, Chia-Hua Kuo, Lung-Fa Pan, Yueh-Min Lin, Chun-Hsu Yao, Yueh-Sheng Chen, Feng-Huei Lin, Wei-Wen Kuo, Chih-Yang Huang
Systemic inflammation induced by bacterial infection is one of several causative agents for cardiovascular disorders in patients with periodontal disease. Experimental results indicate that miRNAs play important roles in systemic inflammation induced by endotoxins. Further evidence states that stem cell based therapy shows potential in the treatment of inflammatory responses induced by sepsis. This study investigates if stem cells show protective effects on cardiomyocyte damage induced by porphyromonas gingivalis-LPS (Pg-LPS) through regulating miRNAs...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29218102/dexmedetomidine-alleviates-lps-induced-septic-cardiomyopathy-via-the-cholinergic-anti-inflammatory-pathway-in-mice
#9
Weilan Kong, Kai Kang, Yang Gao, Haitao Liu, Xianglin Meng, Songliu Yang, Kaijiang Yu, Mingyan Zhao
This study was conducted to investigate the role of the cholinergic anti-inflammatory pathway in LPS-induced septic cardiomyopathy in mice. C57BL/6 mice were used to construct septic cardiomyopathy models. The optimal duration of lipopolysaccharide (LPS) treatment was determined by HE staining and TUNEL assay. Blank controls were intraperitoneally injected with saline and models were injected with LPS (10 mg/kg) (LPS), α-bungarotoxin (BT-LPS), BT and dexmedetomidine (BT-DEX-LPS). The pathological examinations were performed on HE- stained myocardium tissues, apoptosis was determined using TUNEL assay, mRNA expression of NF-κB p65, Caspase-3, Caspase-8, Bcl-2, Bax, p53 and α7nACh was quantified using qRT-PCR, protein levels of IL-6, IL-1β, TNF-α and phosphorylated STAT3 (p-STAT3) were analyzed using Western blot analysis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29216952/-sepsis-induced-cardiomyopathy-complicated-with-cardiogenic-shock-patients-supported-with-extracorporeal-membrane-oxygenation
#10
Changzhi Liu, Ruiqiu Zhu, Zhujiang Zhou, Haifeng Liu, Jingcheng Lin, Shuchao Wen, Liuer Zuo
Sepsis-induced cardiomyopathy is a reversible myocardial dysfunction due to sepsis, which may be severe enough to complicate cardiogenic shock, and without effective drug and with high mortality during the acute phase. A case of sepsis-induced cardiomyopathy complicated with cardiogenic shock was treated in the intensive care unit (ICU) of Shunde Hospital Southern Medical University. A 37 years old female patient was admitted because she had suffered repeated fever for 5 days, chest tightness and abdominal pain for 3 days...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29180214/thioredoxin-1-attenuates-sepsis-induced-cardiomyopathy-after-cecal-ligation-and-puncture-in-mice
#11
Rickesha L Wilson, Vaithinathan Selvaraju, Rajesh Lakshmanan, Mahesh Thirunavukkarasu, Jacob Campbell, David W McFadden, Nilanjana Maulik
BACKGROUND: Sepsis is a leading cause of mortality among patients in intensive care units across the USA. Thioredoxin-1 (Trx-1) is an essential 12 kDa cytosolic protein that, apart from maintaining the cellular redox state, possesses multifunctional properties. In this study, we explored the possibility of controlling adverse myocardial depression by overexpression of Trx-1 in a mouse model of severe sepsis. METHODS: Adult C57BL/6J and Trx-1Tg/+ mice were divided into wild-type sham (WTS), wild-type cecal ligation and puncture (WTCLP), Trx-1Tg/+ sham (Trx-1Tg/+ S), and Trx-1Tg/+ CLP groups...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29175266/tumor-necrosis-factor-receptor-associated-factor-6-as-a-nuclear-factor-kappa-b-modulating-therapeutic-target-in-cardiovascular-diseases-at-the-heart-of-it-all
#12
REVIEW
Muhammad Abdullah, Jessica M Berthiaume, Monte S Willis
Inflammatory and immune signaling has been documented as a root cause of many cardiovascular pathologies. In this review, we explore the emerging role of tumor necrosis factor receptor-associated factor 6 (TRAF6)-nuclear factor kappa B (NF-κB) signaling axis in atherosclerosis, ischemic heart disease, pathologic cardiac hypertrophy or heart failure, myocarditis, and sepsis-induced cardiomyopathy. We discuss the current understanding of cardiac inflammation in heart disease, present the TRAF6 signaling axis in the heart, then summarize what is known about TRAF6 in pathophysiology of heart disease including proof-of-concept studies that identify the utility of blocking TRAF6 to attenuate cardiac dysfunction, which suggests that TRAF6 is a novel, druggable target in treating cardiovascular disease incurred by inflammatory processes...
November 7, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29150444/toll-like-receptor-4-induced-ryanodine-receptor-2-oxidation-and-sarcoplasmic-reticulum-ca-2-leakage-promote-cardiac-contractile-dysfunction-in-sepsis
#13
Jie Yang, Rui Zhang, Xin Jiang, Jingzhang Lv, Ying Li, Hongyu Ye, Wenjuan Liu, Gang Wang, Cuicui Zhang, Na Zheng, Ming Dong, Yan Wang, Peiya Chen, Kumar Santosh, Yong Jiang, Jie Liu
Studies suggest the potential role of a sarcoplasmic reticulum (SR) Ca2+ leak in cardiac contractile dysfunction in sepsis. However, direct supporting evidence is lacking, and the mechanisms underlying this SR leak are poorly understood. Here, we investigated the changes in cardiac Ca2+ handling and contraction in LPS-treated rat cardiomyocytes and a mouse model of polymicrobial sepsis produced by cecal ligation and puncture (CLP). LPS decreased the systolic Ca2+ transient and myocyte contraction as well as SR Ca2+ content...
January 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29117918/lack-of-soluble-circulating-cardiodepressant-factors-in-takotsubo-cardiomyopathy
#14
Chiara Sonnino, Benjamin W Van Tassell, Stefano Toldo, Marco Giuseppe Del Buono, F Gerard Moeller, Antonio Abbate
Circulating cardiodepressant factors were found to mediate cardiac dysfunction in patients with sepsis and acute systolic heart failure. To investigate the presence of circulating cardiodepressant factors in patients with Takotsubo Cardiomyopathy (TC), plasma samples were collected from 4 patients with TC, 3 with septic shock, 5 with acute systolic heart failure and 4 healthy controls and injected intraperitoneally in mice. The cardiodepressant effects are measured with transthoracic echocardiography. Plasma injection from control and TC subjects had no effects on left ventricle ejection fraction (LVEF) whereas plasma from the other two groups induced a significant reduction in LVEF...
December 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29100618/incidence-and-evolution-of-sepsis-induced-cardiomyopathy-in-a-cohort-of-patients-with-sepsis-and-septic-shock
#15
I Narváez, A Canabal, C Martín, M Sánchez, A Moron, J Alcalá, S Giacoman, M Magro
OBJETIVE: The aim of this study was to establish the incidence of septic cardiomyopathy (SM) in patients with sepsis and septic shock, to describe its characteristics and testing its evolution. DESIGN: Prospective cohort study. PARTICIPANTS: We included 57 consecutive patients admitted to Intensive Care Unit, who met criteria of sepsis and septic shock. PRINCIPAL VARIABLES OF INTEREST: Clinical and biochemical variables were analyzed...
October 31, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29057035/sepsis-induced-cardiomyopathy-oxidative-implications-in-the-initiation-and-resolution-of-the-damage
#16
REVIEW
Vasiliki Tsolaki, Demosthenes Makris, Konstantinos Mantzarlis, Epameinontas Zakynthinos
Cardiac dysfunction may complicate the course of severe sepsis and septic shock with significant implications for patient's survival. The basic pathophysiologic mechanisms leading to septic cardiomyopathy have not been fully clarified until now. Disease-specific treatment is lacking, and care is still based on supportive modalities. Septic state causes destruction of redox balance in many cell types, cardiomyocytes included. The production of reactive oxygen and nitrogen species is increased, and natural antioxidant systems fail to counterbalance the overwhelming generation of free radicals...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28970829/sepsis-induced-cardiomyopathy-mechanisms-and-treatments
#17
REVIEW
Yan-Cun Liu, Mu-Ming Yu, Song-Tao Shou, Yan-Fen Chai
Sepsis is a lethal syndrome with a high incidence and a weighty economy burden. The pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of coagulation, while sepsis-induced cardiomyopathy (SIC), defined as a global but reversible dysfunction of both sides of the heart induced by sepsis, plays a significant role in all of the aspects above in the pathogenesis of sepsis. The complex pathogenesis of SIC involves a combination of dysregulation of inflammatory mediators, mitochondrial dysfunction, oxidative stress, disorder of calcium regulation, autonomic nervous system dysregulation, and endothelial dysfunction...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28878116/inhibition-of-nadph-oxidase-2-nox2-prevents-sepsis-induced-cardiomyopathy-by-improving-calcium-handling-and-mitochondrial-function
#18
Leroy C Joseph, Dimitra Kokkinaki, Mesele-Christina Valenti, Grace J Kim, Emanuele Barca, Dhanendra Tomar, Nicholas E Hoffman, Prakash Subramanyam, Henry M Colecraft, Michio Hirano, Adam J Ratner, Muniswamy Madesh, Konstantinos Drosatos, John P Morrow
Cardiomyopathy frequently complicates sepsis and is associated with increased mortality. Increased cardiac oxidative stress and mitochondrial dysfunction have been observed during sepsis, but the mechanisms responsible for these abnormalities have not been determined. We hypothesized that NADPH oxidase 2 (NOX2) activation could be responsible for sepsis-induced oxidative stress and cardiomyopathy. Treatment of isolated adult mouse cardiomyocytes with low concentrations of the endotoxin lipopolysaccharide (LPS) increased total cellular reactive oxygen species (ROS) and mitochondrial superoxide...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28720602/a-reminder-of-escherichia-coli-sepsis-induced-reversible-cardiomyopathy
#19
Aung Naing Lin, Atif Shaikh, Sithu Lin, Deepika Misra
Cardiomyopathy is a progressive disease of myocardium causing either mechanical or electrical disturbances. Sepsis-induced cardiomyopathy (SICM) is an entity of cardiomyopathy which is reversible in 1â€"2 weeks after recovery from sepsis or septic shock. SICM is thought to have unpredictable cumulative mortality towards sepsis but its exact mechanism remains elusive. We report a case of Escherichia coli SICM in a 63-year-old woman presented with sudden onset of dyspnoea on exertion and orthopnoea following nausea, vomiting and diarrhoea after consuming Chinese foods...
July 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28662012/fatal-course-of-takotsubo-cardiomyopathy-in-a-female-with-recurrent-clostridium-difficile-infection
#20
Waldemar Elikowski, Małgorzata Małek-Elikowska, Monika Lisiecka, Iwona Mozer-Lisewska
Among diverse triggering factors of stress-induced takotsubo cardiomyopathy (TC), a viral or bacterial infection is rarely observed. Sepsis is an exception, regardless of the etiologic pathogen, in which case an excess of catecholamines may result in acute left ventricular dysfunction. TC precipitated by Clostridium difficile infection (CDI) has been reported only in two patients so far. A CASE REPORT: The authors describe another case of TC triggered this time by recurrent C. difficile colitis which occurred in a 72-yearold female...
June 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
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