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https://www.readbyqxmd.com/read/27613921/resting-state-functional-connectivity-of-the-basal-nucleus-of-meynert-in-cigarette-smokers-dependence-level-and-gender-differences
#1
Sheng Zhang, Sien Hu, Lisa M Fucito, Xingguang Luo, Carolyn M Mazure, Laszlo Zaborszky, Chiang-Shan R Li
INTRODUCTION: Numerous studies have characterized impaired cerebral functioning in nicotine-addicted individuals. Whereas nicotine interacts with multiple neurotransmitters in cortical and subcortical circuits, it directly targets the cholinergic system, sourced primarily from the basal nucleus of Meynert (BNM). However, no studies have examined how this cholinergic system is influenced by cigarette smoking. Here, we addressed this gap of research. METHODS: Using a dataset from the Functional Connectome Projects, we investigated this issue by contrasting seed-based BNM connectivity of 40 current smokers and 170 age- and gender-matched nonsmokers...
August 17, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27554598/short-term-culture-of-monocytes-as-an-in%C3%A2-vitro-evaluation-system-for-bionanomaterials-designated-for-medical-use
#2
Ekaterina Igorevna Shishatskaya, Dragana Nikitovic, Alexander Shabanov Vasilievich, George N Tzanakakis, Aristidis M Tsatsakis, Natalia Gennadievna Menzianova
We studied the feasibility of using a short-term culture of monocytes, isolated from peripheral donor blood, to assess the biological activity of different types of bionanomaterials (BNM): biodegradable polimeric particles, fiber and film substrates of micro- and nano-dimensions, fullerenes (F) and nanodiamonds (ND), which are either currently in use and/or potentially applicable in medicine. Additionally, the effect of creating a protein corona on ND and F particles was investigated. The cellular reduction of (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) is a well-established tool for assessing the viability/metabolic activity of cells...
October 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27454460/root-coverage-procedures-improve-patient-aesthetics-a-systematic-review-and-bayesian-network-meta-analysis
#3
Francesco Cairo, Umberto Pagliaro, Jacopo Buti, Michela Baccini, Filippo Graziani, Paolo Tonelli, Gabriella Pagavino, Maurizio S Tonetti
BACKGROUND: The aim of this study was to perform a systematic review (SR) of randomized controlled trials (RCTs) to explore if periodontal plastic surgery procedures for the treatment of single and multiple gingival recessions (Rec) may improve aesthetics at patient and professional levels. MATERIAL AND METHODS: In order to combine evidence from direct and indirect comparisons by different trials a Bayesian network meta-analysis (BNM) was planned. A literature search on PubMed, Cochrane libraries, EMBASE, and hand-searched journals until January 2016 was conducted to identify RCTs presenting aesthetic outcomes after root coverage using standardized evaluations at patient and professional level...
November 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27277439/bladder-neck-evaluation-by-perineal-ultrasound-before-and-after-reconstructive-surgery-for-pelvic-organ-prolapse
#4
Manabu Nishibayashi, Koichi Kobayashi, Akinori Miki, Ryugo Okagaki, Ichiro Nagata, Mitsuyoshi Urashima, Osamu Ishihara
PURPOSE: To study the correlation between stress urinary incontinence (SUI) and the mobility and funneling of the bladder neck (BN) by observation of pre- and postoperative course by perineal ultrasound (PUS). METHODS: We investigated 123 cases that underwent reconstructive surgery for pelvic organ prolapse (POP). We prospectively checked bladder neck mobility (BNM) during the Valsalva maneuver and funneling of the BN at rest by PUS. We defined the width multiplied by the depth of the funnel-like profile of the BN as the funneling index (FI)...
December 2009: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27148006/the-effects-of-methylphenidate-on-resting-state-functional-connectivity-of-the-basal-nucleus-of-meynert-locus-coeruleus-and-ventral-tegmental-area-in-healthy-adults
#5
Ryan L Kline, Sheng Zhang, Olivia M Farr, Sien Hu, Laszlo Zaborszky, Gregory R Samanez-Larkin, Chiang-Shan R Li
BACKGROUND: Methylphenidate (MPH) influences catecholaminergic signaling. Extant work examined the effects of MPH on the neural circuits of attention and cognitive control, but few studies have investigated the effect of MPH on the brain's resting-state functional connectivity (rsFC). METHODS: In this observational study, we compared rsFC of a group of 24 healthy adults who were administered an oral 45 mg dose of MPH with a group of 24 age and gender matched controls who did not receive MPH...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/26904769/-attitudes-and-opinions-of-general-practitioners-and-lung-specialists-about-a-new-medicines-counselling-service-for-asthma-patients-in-community-pharmacies-a-qualitative-study
#6
E Matthé, J Fraeyman, H De Loof, G De Myer
INTRODUCTION: Since October 2013, pharmacists can offer a new medicines counselling service (NMC). to asthma patients, who start a treatment with an inhaled corticosteroid. Although this individualized service can be organized at the request of the general practitioner (GP). the patient or the pharmacist, the uptake remains quite low. The limited involvement of GPs has already been identified as one of the obstacles to the successful implementation of this project. OBJECTIVE: To explore the attitudes and opinions of GPs and pulmonologists about NMC...
December 2015: Journal de Pharmacie de Belgique
https://www.readbyqxmd.com/read/26789542/correlation-between-bladder-neck-mobility-and-voiding-phase-urodynamic-parameters-in-female-patients-with-stress-urinary-incontinence
#7
I-Shen Huang, Yu-Hua Fan, Alex T L Lin, Kuang-Kuo Chen
OBJECTIVE: The correlation between bladder neck mobility (BNM) and voiding function in females has not been examined before. This study investigated the correlation between BNM and voiding phase urodynamic parameters in female patients with stress urinary incontinence (SUI). METHODS: We recruited female patients with SUI between January 2005 and 2010. All patients underwent video urodynamic study (VUDS) including measurement of the bladder neck descent using the Valsalva maneuver and leak point pressure...
January 2016: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/26573569/a-boolean-network-model-of-human-gonadal-sex-determination
#8
Osiris Ríos, Sara Frias, Alfredo Rodríguez, Susana Kofman, Horacio Merchant, Leda Torres, Luis Mendoza
BACKGROUND: Gonadal sex determination (GSD) in humans is a complex biological process that takes place in early stages of embryonic development when the bipotential gonadal primordium (BGP) differentiates towards testes or ovaries. This decision is directed by one of two distinct pathways embedded in a GSD network activated in a population of coelomic epithelial cells, the Sertoli progenitor cells (SPC) and the granulosa progenitor cells (GPC). In males, the pathway is activated when the Sex-Determining Region Y (SRY) gene starts to be expressed, whereas in females the WNT4/ β-catenin pathway promotes the differentiation of the GPCs towards ovaries...
2015: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/26357332/bayesian-normalization-model-for-label-free-quantitative-analysis-by-lc-ms
#9
Mohammad R Nezami Ranjbar, Mahlet G Tadesse, Yue Wang, Habtom W Ressom
We introduce a new method for normalization of data acquired by liquid chromatography coupled with mass spectrometry (LC-MS) in label-free differential expression analysis. Normalization of LC-MS data is desired prior to subsequent statistical analysis to adjust variabilities in ion intensities that are not caused by biological differences but experimental bias. There are different sources of bias including variabilities during sample collection and sample storage, poor experimental design, noise, etc. In addition, instrument variability in experiments involving a large number of LC-MS runs leads to a significant drift in intensity measurements...
July 2015: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/26146457/effective-treatment-of-alkaline-cr-vi-contaminated-leachate-using-a-novel-pd-bionanocatalyst-impact-of-electron-donor-and-aqueous-geochemistry
#10
Mathew P Watts, Victoria S Coker, Stephen A Parry, Russell A P Thomas, Robert Kalin, Jonathan R Lloyd
Palladium catalysts offer the potential for the effective treatment of a variety of priority reducible pollutants in natural waters. In this study, microbially synthesized magnetite nanoparticles were functionalized with Pd(0), creating a highly reactive, magnetically recoverable, nano-scale catalyst (Pd-BnM). This was then investigated for the treatment of model Cr(VI) contaminated solutions at a range of pH values, and also alkaline Cr(VI) contaminated leachates from chromite ore processing residue (COPR); a contaminant issue of global concern...
July 2015: Applied Catalysis. B, Environmental
https://www.readbyqxmd.com/read/26109747/biogenic-nano-magnetite-and-nano-zero-valent-iron-treatment-of-alkaline-cr-vi-leachate-and-chromite-ore-processing-residue
#11
Mathew P Watts, Victoria S Coker, Stephen A Parry, Richard A D Pattrick, Russell A P Thomas, Robert Kalin, Jonathan R Lloyd
Highly reactive nano-scale biogenic magnetite (BnM), synthesized by the Fe(III)-reducing bacterium Geobacter sulfurreducens, was tested for the potential to remediate alkaline Cr(VI) contaminated waters associated with chromite ore processing residue (COPR). The performance of this biomaterial, targeting aqueous Cr(VI) removal, was compared to a synthetic alternative, nano-scale zero valent iron (nZVI). Samples of highly contaminated alkaline groundwater and COPR solid waste were obtained from a contaminated site in Glasgow, UK...
March 2015: Applied Geochemistry: Journal of the International Association of Geochemistry and Cosmochemistry
https://www.readbyqxmd.com/read/25592995/mathematical-framework-for-large-scale-brain-network-modeling-in-the-virtual-brain
#12
Paula Sanz-Leon, Stuart A Knock, Andreas Spiegler, Viktor K Jirsa
In this article, we describe the mathematical framework of the computational model at the core of the tool The Virtual Brain (TVB), designed to simulate collective whole brain dynamics by virtualizing brain structure and function, allowing simultaneous outputs of a number of experimental modalities such as electro- and magnetoencephalography (EEG, MEG) and functional Magnetic Resonance Imaging (fMRI). The implementation allows for a systematic exploration and manipulation of every underlying component of a large-scale brain network model (BNM), such as the neural mass model governing the local dynamics or the structural connectivity constraining the space time structure of the network couplings...
May 1, 2015: NeuroImage
https://www.readbyqxmd.com/read/25530300/synthesis-and-systematic-evaluation-of-dark-resonance-energy-transfer-dret-based-library-and-its-application-in-cell-imaging
#13
Dongdong Su, Chai Lean Teoh, Nam-Young Kang, Xiaotong Yu, Srikanta Sahu, Young-Tae Chang
In this paper, we report a new strategy for constructing a dye library with large Stokes shifts. By coupling a dark donor with BODIPY acceptors of tunable high quantum yield, a novel dark resonance energy transfer (DRET)-based library, named BNM, has been synthesized. Upon excitation of the dark donor (BDN) at 490 nm, the absorbed energy is transferred to the acceptor (BDM) with high efficiency, which was tunable in a broad range from 557 nm to 716 nm, with a high quantum yield of up to 0.8. It is noteworthy to mention that the majority of the non-radiative energy loss of the donor was converted into the acceptor's fluorescence output with a minimum leak of donor emission...
March 2015: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/25502011/neuroprotective-activity-of-hydroponic-teucrium-polium-following-bilateral-ovariectomy
#14
K V Simonyan, V A Chavushyan
Ovariectomy is known as "surgical menopause" with decreased levels of estrogen in female rodents. Its reported risks and adverse effects include cognitive impairment. The action of hydroponic Teucrium polium on nucleus basalis of Meynert (bnM) neurons following 6 weeks of ovariectomy was carried out. The analysis of spike activity was observed by on-line selection and the use of a software package. Early and late tetanic, - posttetanic potentiation and depression of neurons to high frequency stimulation of hippocampus were studied...
June 2015: Metabolic Brain Disease
https://www.readbyqxmd.com/read/25017226/-clinicopathologic-features-and-risk-factors-of-bilateral-cervical-lymph-node-metastasis-in-head-and-neck-squamous-cell-carcinoma
#15
Bin Di, Xiaoming Li, Qi Song, Shuang Liu, Zhenfeng Tao, Shufen Xiao
OBJECTIVE: To investigate the clinicopathologic features and associated risk factors for bilateral neck node metastasis (BNM) in head and neck squamous cell carcinoma (HNSCC). METHODS: Two hundred eighty-six cases with HNSCC were retrospectively studied, including 83 cases of oral tongue cancers, 101 cases of hypopharyngeal cancers and 102 cases of supraglottic laryngeal cancers. All patients had unilateral or bilateral cervical lymph node metastasis confirmed by postoperative pathologic examinations...
May 2014: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/24736176/resting-state-functional-connectivity-of-the-basal-nucleus-of-meynert-in-humans-in-comparison-to-the-ventral-striatum-and-the-effects-of-age
#16
COMPARATIVE STUDY
Chiang-shan R Li, Jaime S Ide, Sheng Zhang, Sien Hu, Herta H Chao, Laszlo Zaborszky
The basal nucleus of Meynert (BNM) provides the primary cholinergic inputs to the cerebral cortex. Loss of neurons in the BNM is linked to cognitive deficits in Alzheimer's disease and other degenerative conditions. Numerous animal studies described cholinergic and non-cholinergic neuronal responses in the BNM; however, work in humans has been hampered by the difficulty of defining the BNM anatomically. Here, on the basis of a previous study that delineated the BNM of post-mortem human brains in a standard stereotaxic space, we sought to examine functional connectivity of the BNM, as compared to the nucleus accumbens (or ventral striatum, VS), in a large resting state functional magnetic resonance imaging data set...
August 15, 2014: NeuroImage
https://www.readbyqxmd.com/read/23266387/kinetics-and-mechanisms-of-ph-dependent-degradation-of-halonitromethanes-by-uv-photolysis
#17
Jing-Yun Fang, Li Ling, Chii Shang
Halonitromethanes (HNMs) are one of the most toxic groups of disinfection by-products. The pH-dependent degradation kinetics and pathways of four HNMs, namely bromonitromethane (BNM), dichloronitromethane (DCNM), dibromonitromethane (DBNM) and trichloronitromethane (TCNM), by ultraviolet (UV) photolysis at 254 nm were studied at pH 3-9. The UV photolysis in a dilute aqueous solution followed first-order kinetics. The photolysis rates of all four HNMs were low at pH 3-5, while that of TCNM was low at all pHs tested...
March 1, 2013: Water Research
https://www.readbyqxmd.com/read/22784624/biological-network-motif-detection-and-evaluation
#18
Wooyoung Kim, Min Li, Jianxin Wang, Yi Pan
BACKGROUND: Molecular level of biological data can be constructed into system level of data as biological networks. Network motifs are defined as over-represented small connected subgraphs in networks and they have been used for many biological applications. Since network motif discovery involves computationally challenging processes, previous algorithms have focused on computational efficiency. However, we believe that the biological quality of network motifs is also very important. RESULTS: We define biological network motifs as biologically significant subgraphs and traditional network motifs are differentiated as structural network motifs in this paper...
2011: BMC Systems Biology
https://www.readbyqxmd.com/read/22585294/the-impact-of-bladder-neck-mucosal-eversion-during-open-radical-prostatectomy-on-bladder-neck-stricture-and-urinary-extravasation
#19
RANDOMIZED CONTROLLED TRIAL
Gita M Schoeppler, Dirk Zaak, Dirk-Andre Clevert, Petra Schuhmann, Oliver Reich, Michael Seitz, Wael Y Khoder, Michael Staehler, Christian G Stief, Alexander Buchner
PURPOSE: To determine whether the bladder neck mucosal eversion (BNM-eversion) during radical retropubic prostatectomy (RRP) reduces the risk of bladder neck stricture (BNS) and of peri-anastomotic extravasation (PAE) in postoperative cystography. METHODS: Two hundred and eleven patients with clinically localized prostate cancer underwent RRP and were prospectively randomized into patients with BNM-eversion (group I) and without BNM-eversion (group II). All patients underwent an evaluation of PAE by retrograde cystography on postoperative day 8...
October 2012: International Urology and Nephrology
https://www.readbyqxmd.com/read/22095558/bilateral-neck-metastases-in-upper-aero-digestive-tract-cancer-emphasis-on-the-distribution-of-lymphatic-metastases-and-prognostic-implications
#20
Tae Wook Kim, Man Ki Chung, Hye-Youn Youm, Jong-In Jeong, Young-Ik Son, Han-Sin Jeong, Chung-Hwan Baek
BACKGROUND: Bilateral neck metastases (BNM) in patients with upper aero-digestive tract cancer (UADTC) indicate a poor prognosis. However, the prognostic significance of involved neck node levels has not been determined clearly. In this study, the distribution of neck nodal metastasis and its impact on prognosis were investigated. METHODS: Eighty-two previously untreated UADTC patients with BNM from 2000 to 2007 were included in these analyses. The pathology was mainly squamous cell carcinomas, including nasopharynx undifferentiated carcinoma and excluding salivary and thyroid carcinomas...
May 2012: Journal of Surgical Oncology
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