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https://www.readbyqxmd.com/read/29239887/incidence-of-sexually-transmitted-infections-before-and-after-pre-exposure-prophylaxis-for-hiv-a-cohort-study
#1
Vinh-Kim Nguyen, Zoë R Greenwald, Helen Trottier, Martha Cadieux, Alexandre Goyette, Mariève Beauchemin, Louise Charest, Danièle Longpré, Stéphane Lavoie, Hermione Gbego Tossa, Réjean Thomas
OBJECTIVE: Use of Pre-Exposure Prophylaxis (PrEP) for HIV raises concerns about sexually transmitted infection (STI) incidence due to decreased condom use among men who have sex with men (MSM). This study examines whether PrEP is associated with STIs in the 12-months following PrEP prescription relative to the 12-months prior to PrEP and if STI rates are higher among PrEP users relative to individuals receiving Post-Exposure Prophylaxis (PEP). DESIGN: Retrospective cohort study including PrEP users with >12 months of follow-up before PrEP prescription and individuals receiving PEP from 2010-2015 at Clinique l'Actuel (Montréal, Canada)...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29238237/adolescent-pre-exposure-prophylaxis-for-hiv-prevention-current-perspectives
#2
REVIEW
Daisy Maria Machado, Alexandre Machado de Sant'Anna Carvalho, Rachel Riera
Adolescents are a critical population that is disproportionately impacted by the HIV epidemic. More than 2 million adolescents between the age group of 10 and 19 years are living with HIV, and millions are at risk of infection. HIV risks are considerably higher among girls, especially in high-prevalence settings such as eastern and southern Africa. In addition to girls, there are other vulnerable adolescent subgroups, such as teenagers, who use intravenous (IV) drugs, gay and bisexual boys, transgender youth, male sex workers, and people who fall into more than one of these categories...
2017: Adolescent Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29232170/correlates-of-never-testing-for-hiv-among-sexually-active-internet-recruited-gay-bisexual-and-other-men-who-have-sex-with-men-in-the-united-states
#3
Kimberly M Nelson, David W Pantalone, Kristi E Gamarel, Michael P Carey, Jane M Simoni
In the United States, gay, bisexual, and other men who have sex with men (GBMSM) are disproportionately affected by the HIV/AIDS epidemic. Despite great strides in HIV prevention, including biobehavioral HIV prevention strategies such as pre-exposure prophylaxis and treatment as prevention, there has been relatively low uptake of these strategies. The success of biobehavioral prevention strategies requires HIV testing but a subset of GBMSM have never been tested. To optimize prevention efforts, we sought to understand the characteristics of GBMSM who report never testing for HIV...
December 12, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29229609/recent-advances-in-pre-exposure-prophylaxis-for-hiv
#4
REVIEW
Monica Desai, Nigel Field, Robert Grant, Sheena McCormack
Although pre-exposure prophylaxis (PrEP)-the use of antiretroviral drugs by non-infected people to prevent the acquisition of HIV-is a promising preventive option, important public health questions remain. Daily oral emtricitabine (FTC)-tenofovir disoproxil fumarate (TDF) is highly efficacious in preventing the acquisition of HIV in people at risk as a result of a range of different types of sexual exposure. There is good evidence of efficacy in women and men, and when men who have sex with men use event based dosing...
December 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29229440/post-exposure-prophylaxis-with-doxycycline-to-prevent-sexually-transmitted-infections-in-men-who-have-sex-with-men-an-open-label-randomised-substudy-of-the-anrs-ipergay-trial
#5
Jean-Michel Molina, Isabelle Charreau, Christian Chidiac, Gilles Pialoux, Eric Cua, Constance Delaugerre, Catherine Capitant, Daniela Rojas-Castro, Julien Fonsart, Béatrice Bercot, Cécile Bébéar, Laurent Cotte, Olivier Robineau, François Raffi, Pierre Charbonneau, Alexandre Aslan, Julie Chas, Laurence Niedbalski, Bruno Spire, Luis Sagaon-Teyssier, Diane Carette, Soizic Le Mestre, Veronique Doré, Laurence Meyer
BACKGROUND: Increased rates of sexually transmitted infections (STIs) have been reported among men who have sex with men. We aimed to assess whether post-exposure prophylaxis (PEP) with doxycycline could reduce the incidence of STIs. METHODS: All participants attending their scheduled visit in the open-label extension of the ANRS IPERGAY trial in France (men aged 18 years or older having condomless sex with men and using pre-exposure prophylaxis for HIV with tenofovir disoproxil fumarate plus emtricitabine) were eligible for inclusion in this open-label randomised study...
December 8, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29228144/randomized-controlled-trial-of-daily-text-messages-to-support-adherence-to-prep-in-at-risk-for-hiv-individuals-the-tapir-study
#6
David J Moore, Sonia Jain, Michael P Dubé, Eric S Daar, Xiaoying Sun, Jason Young, Katya Corado, Eric Ellorin, Joel Milam, Deborah Collins, Jill Blumenthal, Brookie M Best, Peter Anderson, Richard Haubrich, Sheldon R Morris
Background: Adherence is critical for efficacy of tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis (PrEP). Methods: Between 02/2013 and 02/2016, 398 men who have sex with men and transgender women were randomized 1:1 to receive individualized Texting for Adherence Building (iTAB) or standard care (SoC) for 48 weeks. The primary endpoint was dried blood spot (DBS) tenofovir (TFV-DP) concentrations at both week 12 and week 48 (or the last on-drug visit) of >719 fmol/punch consistent with ≥4 doses per week (i...
November 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29224988/linking-hiv-negative-youth-to-prevention-services-in-12-u-s-cities-barriers-and-facilitators-to-implementing-the-hiv-prevention-continuum
#7
Mimi Doll, J Dennis Fortenberry, Denise Roseland, Kathleen McAuliff, Craig M Wilson, Cherrie B Boyer
PURPOSE: Linkage of HIV-negative youth to prevention services is increasingly important with the development of effective pre-exposure prophylaxis that complements behavioral and other prevention-focused interventions. However, effective infrastructure for delivery of prevention services does not exist, leaving many programs to address HIV prevention without data to guide program development/implementation. The objective of this study was to provide a qualitative description of barriers and facilitators of linkage to prevention services among high-risk, HIV-negative youth...
December 7, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29214409/strategies-to-implement-pre-exposure-prophylaxis-with-men-who-have-sex-with-men-in-ukraine
#8
Alex Dubov, Liana Fraenkel, Roman Yorick, Adedotun Ogunbajo, Frederick L Altice
Ukrainian men who have sex with men (MSM) remain highly stigmatized group with HIV prevalence as high as 23%. Despite documented effectiveness of pre-exposure prophylaxis (PrEP), PrEP remains unavailable in Ukraine. The aim of this study was to elicit MSM preferences in order to inform program development to facilitate successful delivery of PrEP to Ukrainian MSM. 1184 MSM were recruited through social networking applications to complete a stated preference (choice-based conjoint) survey. Respondents completed 14 choice tasks presenting experimentally-varied combinations of five attributes related to PrEP administration (dosing frequency, dispensing venue, prescription practices, adherence support, and costs)...
December 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29211515/factors-associated-with-use-of-short-term-pre-exposure-prophylaxis-for-hiv-among-female-partners-of-migrant-miners-in-mozambique
#9
Joana Falcao, Allison Zerbe, Maria Lahuerta, Rachel Baggaley, Laurence Ahoua, Pietro DiMattei, Fernando Morales, Isaias Ramiro, Wafaa M El-Sadr
Effective interventions tailored to specific types of behaviors and contexts are needed for women at risk for HIV acquisition. Oral pre-exposure prophylaxis (PrEP) is an efficacious HIV prevention intervention that uses antiretroviral drugs to reduce the risk of acquiring HIV infection. In Mozambique, HIV remains a major public health concern, with a national prevalence of 13%. Studies have demonstrated that the migration of male miners between southern provinces of Mozambique and South Africa is contributing to the HIV epidemic in Mozambique...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211514/hiv-care-providers-intentions-to-prescribe-and-actual-prescription-of-pre-exposure-prophylaxis-to-at-risk-adolescents-and-adults
#10
Tanya L Kowalczyk Mullins, Gregory Zimet, Michelle Lally, Jiahong Xu, Sarah Thornton, Jessica A Kahn
Pre-exposure prophylaxis (PrEP) is indicated for use in US adults, and little is known about clinician intentions to prescribe and actual prescription of PrEP to adolescents younger than 18. Fifty-six clinicians who care for HIV-infected and at-risk youth completed an anonymous online survey in 2014. Primary outcomes were (1) intentions to prescribe PrEP to adolescents and adults in four risk categories [men who have sex with men (MSM), transgender women, heterosexuals with multiple partners of unknown HIV status, heterosexuals with HIV-infected partners]; and (2) actual prescription of PrEP to adolescents and adults in these risk groups...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211513/facilitators-and-barriers-to-pre-exposure-prophylaxis-willingness-among-young-men-who-have-sex-with-men-who-use-geosocial-networking-applications-in-california
#11
Ian W Holloway, Diane Tan, Jennifer L Gildner, Sean C Beougher, Craig Pulsipher, Jorge A Montoya, Aaron Plant, Arleen Leibowitz
While correlates of pre-exposure prophylaxis (PrEP) uptake have been explored among older men who have sex with men (MSM), less is known about the facilitators and barriers that encourage uptake among younger MSM (YMSM). This study explores the association between willingness to take PrEP and demographic characteristics, sexual risk, and substance use, and attitudinal factors among YMSM in California who use geosocial networking applications (GSN apps). Based on survey data from YMSM recruited through GSN apps (n = 687), PrEP willingness was positively associated with Hispanic ethnicity [adjusted odds ratio (aOR): 1...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29210835/-medication-adherence-in-a-nationwide-cohort-of-veterans-initiating-pre-exposure-prophylaxis-prep-to-prevent-hiv-infection
#12
Puja van Epps, Marissa Maier, Brian Lund, M Bryant Howren, Brice Beck, Lauren Beste, Avy Skolnik, Mary Vaughan-Sarrazin, Michael E Ohl
BACKGROUND: Current guidelines for pre-exposure prophylaxis (PrEP) to prevent HIV infection call for long-term, daily use of tenofovir disoproxil fumarate / emtricitabine (TDF/FTC). Little is known about long-term adherence with TDF/FTC prescribed for PrEP in routine clinical practice. SETTING: Veterans Health Administration (VHA) clinics METHODS:: We used VHA data to create a nationwide cohort of Veterans initiating PrEP between July 1, 2012 and June 30, 2016. We examined pharmacy refill data to estimate adherence based on the proportion of days covered (PDC) by TDF/FTC in the first year, and used logistic regression to identify patient characteristics associated with high adherence (i...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210834/pre-exposure-prophylaxis-prep-use-and-condomless-anal-sex-evidence-of-risk-compensation-in-a-cohort-of-young-men-who-have-sex-with-men
#13
Michael E Newcomb, Kevin Moran, Brian A Feinstein, Emily Forscher, Brian Mustanski
BACKGROUND: Young men who have sex with men (YMSM) are disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV acquisition. It remains unclear if PrEP use increases rates of condomless sex (i.e., risk compensation), which may increase risk of infection if PrEP adherence is not optimal. This study aimed to examine whether PrEP use and PrEP adherence were associated with change in sexual risk behaviors in a large longitudinal cohort of YMSM reporting on multiple sexual partnerships over time...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210831/correlates-of-linkage-to-hiv-pre-exposure-prophylaxis-prep-among-hiv-testing-clients
#14
Charlene A Flash, Oluwatobi O Adegboyega, Xiaoying Yu, Carmen Avalos, Syundai Johnson, Kenneth H Mayer, Thomas P Giordano
BACKGROUND: Publicly funded HIV testing sites can identify HIV pre-exposure prophylaxis (PrEP) candidates and provide PrEP linkage. SETTING: Harris Health System's HIV clinic, HIV testing program and HIV Prevention Program in Houston, TX, a high HIV incidence city. METHODS: A prospective assessment of individuals ≥18 years old recruited from walk-in HIV testing December, 2013 to April, 2015 included risk assessment, HIV testing and self-administered survey, with follow-up surveys at 6 and 12 months and medical record review...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29208161/hepatitis-a-outbreak-in-hiv-infected-msm-and-in-prep-using-msm-despite-a-high-level-of-immunity-lyon-france-january-to-june-2017
#15
Caroline Charre, Christophe Ramière, Anne-Marie Roque-Afonso, Christian Chidiac, Fabien Zoulim, Matthieu Godinot, Joseph Koffi, Caroline Scholtès, Jean-Michel Livrozet, Hav Lyon Study Group, Laurent Cotte
Since 2016, an increase in the number of hepatitis A cases affecting mainly men who have sex with men (MSM) has been reported in low endemic countries in Europe. We calculated the attack rate in Lyon, France, in populations considered at high-risk: HIV-infected MSM and HIV-negative MSM receiving HIV pre-exposure prophylaxis (PrEP). In these populations, high level of immunity did not prevent the outbreak, indicating that vaccination should be reinforced, particularly in younger individuals.
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29208160/hiv-epidemic-among-men-who-have-sex-with-men-in-the-czech-republic-2016-high-time-for-targeted-action
#16
Viktor Mravčík, Michal Pitoňák, Robert Hejzák, Barbara Janíková, Ivo Procházka
Reported incidence of human immunodeficiency virus (HIV) infection in the Czech Republic increased steeply over the past decade from 90 new cases in 2005 to 266 in 2015. This increase is almost exclusively attributed to sexual transmissions between men who have sex with men (MSM). In 2015, there were 79% (n=210) newly diagnosed cases among MSM, 17% (n=45) were attributed to heterosexual transmission and 1% (n=3) to people who inject drugs. Interventions targeted at MSM have not yet been prioritised in the broadly focused national HIV prevention strategy which this is envisaged to change in the programme set out for 2018 to 2022...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29208157/using-data-from-a-behavioural-survey-of-men-who-have-sex-with-men-msm-to-estimate-the-number-likely-to-present-for-hiv-pre-exposure-prophylaxis-prep-in-ireland-2017
#17
Laura Nic Lochlainn, Kate O'Donnell, Caroline Hurley, Fiona Lyons, Derval Igoe
In Ireland, men who have sex with men (MSM) have increased HIV risk. Pre-exposure prophylaxis (PrEP), combined with safe sex practices, can reduce HIV acquisition. We estimated MSM numbers likely to present for PrEP by applying French PrEP criteria to Irish MSM behavioural survey data. We adjusted for survey bias, calculated proportions accessing testing services and those likely to take PrEP. We estimated 1-3% of MSM in Ireland were likely to present for PrEP.
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29201531/stigma-partners-providers-and-costs-potential-barriers-to-prep-uptake-among-us-women
#18
Lakshmi Goparaju, Nathan C Praschan, Lari Warren-Jeanpiere, Laure S Experton, Mary A Young, Seble Kassaye
Background: Pre-Exposure Prophylaxis (PrEP) use has remained low among US women while significantly increasing among men who have sex with men. Besides lack of awareness, women face several social and structural barriers in gaining access to and using PrEP. Methods: Four focus group discussions with 20 HIV-negative women who live in the Washington DC metropolitan area. Results: The women expressed concerns about social and structural barriers to PrEP use...
September 2017: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/29192368/are-anal-sex-roles-associated-with-preferences-for-pre-exposure-prophylaxis-administration-modalities-among-men-who-have-sex-with-men
#19
William C Goedel, John A Schneider, H Rhodes Hambrick, Noah T Kreski, Jace G Morganstein, Su Hyun Park, Ofole Mgbako, Dustin T Duncan
The current study sought to examine awareness of, willingness to use, and preferences for available and theoretical administration modalities for HIV pre-exposure prophylaxis (PrEP) and the association of anal sex roles with these concepts among a sample of men who have sex with men (MSM) in Paris, France. Broadcast advertisements were placed on a popular geosocial-networking smartphone application for MSM to direct users to complete a Web-based survey. MSM answered questions on their recent engagement in condomless anal intercourse and awareness of and willingness to use PrEP in the form of once daily and event-driven pill regimens, long-acting injections, and penile and rectal microbicides as well as sexual roles...
November 30, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29190784/hiv-transmission-and-pre-exposure-prophylaxis-in-a-high-risk-msm-population-a-simulation-study-of-location-based-selection-of-sexual-partners
#20
Olivier Robineau, Annie Velter, Francis Barin, Pierre-Yves Boelle
OBJECTIVE: In France, indications for pre-exposure prophylaxis (PrEP) for HIV prevention are based on individual-level risk factors for HIV infection. However, the risk of HIV infection may also depend on characteristics of sexual partnerships. Here we study how place-based selection of partners change transmission and the overall efficiency of PrEP. METHODS: We used the PREVAGAY survey of sexual behavior and HIV serostatus in men who have sex with men (MSM) in a Parisian district to look for associations between sexual network characteristics and HIV infection...
2017: PloS One
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