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https://www.readbyqxmd.com/read/27919905/nhs-to-fund-large-trial-of-pre-exposure-prophylaxis-for-hiv-prevention
#1
Susan Mayor
No abstract text is available yet for this article.
December 5, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27918880/racial-differences-in-hiv-and-hcv-risk-behaviors-transmission-and-prevention-knowledge-among-non-treatment-seeking-individuals-with-opioid-use-disorder
#2
Verena E Metz, Maria A Sullivan, Jermaine D Jones, Elizabeth Evans, Rachel Luba, Jonathan Vogelman, Sandra D Comer
In light of New York's recently reinforced strategy to end the AIDS epidemic by expanding testing, treatment, and access to pre-exposure prophylaxis (PrEP), we assessed drug use and sexual risk behaviors, along with HIV/Hepatitis C virus (HCV) transmission and prevention knowledge among non-treatment-seeking adults with opioid use disorder (OUD) in New York City. Over the course of 18 months, volunteers screening for research studies in the Opioid Laboratory at the New York State Psychiatric Institute completed a locally developed self-assessment questionnaire...
December 5, 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27918570/hiv-pre-exposure-prophylaxis-is-it-just-about-pills
#3
Jose V Fernandez-Montero
The increasing use of antiretrovirals for averting HIV infection before potential exposure is under debate. Whereas there is no doubt about the benefit of using Truvada® (tenofovir plus emtricitabine) to reduce HIV acquisition in uninfected persons who have sex with HIV-infected stable partners, concerns are rising about the increasing rate of sexually transmitted infections in subjects engaged in sex with multiple partners, due to misinterpreted self-security.
October 2016: AIDS Reviews
https://www.readbyqxmd.com/read/27914484/comparing-non-occupational-post-exposure-prophylaxis-drug-regimens-for-hiv-insights-from-a-linked-hiv-surveillance-system
#4
Anna B Pierce, Carol El-Hayek, Damien McCarthy, Jude Armishaw, Kerrie Watson, Anna Wilkinson, Brian Price, Edwina J Wright, Jennifer F Hoy, Mark A Stoové
Background: International non-occupational post-exposure prophylaxis (NPEP) guidelines recommend routine use of three drug NPEP regimens, despite absence of evidence for greater prevention efficacy compared with two drug regimens. This study examines the potential for excess HIV seroconversions among high-risk men who have sex with men (MSM) reporting receptive anal intercourse with a source of unknown HIV serostatus (RAIU) following a two-drug versus a three-drug NPEP regimen. Methods: Data for MSM in the Victorian NPEP service database between 10 August 2005 and 31 December 2012 were linked with all Victorian HIV notifications up to 31 December 2013...
December 5, 2016: Sexual Health
https://www.readbyqxmd.com/read/27910722/post-exposure-prophylaxis-awareness-and-use-among-men-who-have-sex-with-men-in-london-who-use-geosocial-networking-smartphone-applications
#5
William C Goedel, Daniel Hagen, Perry N Halkitis, Richard E Greene, Marybec Griffin-Tomas, Forrest A Brooks, DeMarc Hickson, Dustin T Duncan
The number of new HIV infections continues to be on the rise in many high-income countries, most notably among men who have sex with men (MSM). Despite recent attention to the use of antiretroviral medications as pre-exposure prophylaxis (PrEP) among MSM, considerably less research has been devoted to examining the awareness and use of post-exposure prophylaxis (PEP). Based on a convenience sample of 179 self-reported HIV-uninfected MSM using a geosocial-networking smartphone application, this study is among the first to examine the awareness and use of PEP and their demographic and behavioral correlates among MSM in London...
December 2, 2016: AIDS Care
https://www.readbyqxmd.com/read/27905998/sexually-transmitted-infections-and-pre-exposure-prophylaxis-challenges-and-opportunities-among-men-who-have-sex-with-men-in-the-us
#6
REVIEW
Hyman M Scott, Jeffrey D Klausner
Pre-Exposure Prophylaxis (PrEP) has shown high efficacy in preventing human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) in several large clinical trials, and more recently in "real world" reports of clinical implementation and a PrEP demonstration project. Those studies also demonstrated high bacterial sexually transmitted infection (STI) incidence and raised the discussion of how PrEP may impact STI control efforts, especially in the setting of increasing Neisseria gonorrhoeae antimicrobial resistance and the increase in syphilis cases among MSM...
January 19, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27902508/cabotegravir-long-acting-injection-protects-macaques-against-intravenous-challenge-with-sivmac251
#7
Chasity D Andrews, Leslie S T Bernard, Amanda Yee Poon, Hiroshi Mohri, Natanya Gettie, William R Spreen, Agegnehu Gettie, Kasi Russell-Lodrigue, James Blanchard, Zhi Hong, David D Ho, Martin Markowitz
OBJECTIVE: We evaluated the effectiveness of cabotegravir (CAB; GSK1265744 or GSK744) long-acting (LA) as pre-exposure prophylaxis (PrEP) against intravenous SIV challenge in a model that mimics blood transfusions based on the per-act probability of infection. DESIGN: CAB LA is an InSTI formulated as a 200 mg/mL injectable nanoparticle suspension that is an effective pre-exposure prophylaxis (PrEP) agent against rectal and vaginal SHIV transmission in macaques...
November 29, 2016: AIDS
https://www.readbyqxmd.com/read/27900741/-from-evidence-to-health-policy-making-pre-exposure-prophylaxis-for-hiv-prevention
#8
Nai-Ying Ko
Pre-exposure prophylaxis (PrEP), in combination with traditional prevention strategies (such as condom use, voluntary HIV counseling and testing, and treatment for sexually transmitted infections), has been shown to effectively prevent HIV infection. As of September 2015, the World Health Organization recommends that people at substantial risk of HIV infection should be offered PrEP as an additional prevention choice, as part of comprehensive prevention. This article introduces how to apply a systematic review using the methodology of Grading of Recommendations Assessment, Development and Evaluation (GRADE) to write clinical guidelines...
December 2016: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/27900502/values-and-preferences-on-the-use-of-oral-pre-exposure-prophylaxis-prep-for-hiv-prevention-among-multiple-populations-a-systematic-review-of-the-literature
#9
Florence M Koechlin, Virginia A Fonner, Sarah L Dalglish, Kevin R O'Reilly, Rachel Baggaley, Robert M Grant, Michelle Rodolph, Ioannis Hodges-Mameletzis, Caitlin E Kennedy
Daily oral pre-exposure prophylaxis (PrEP) is the use of antiretroviral drugs by HIV-negative people to prevent HIV infection. WHO released new guidelines in 2015 recommending PrEP for all populations at substantial risk of HIV infection. To prepare these guidelines, we conducted a systematic review of values and preferences among populations that might benefit from PrEP, women, heterosexual men, young women and adolescent girls, female sex workers, serodiscordant couples, transgender people and people who inject drugs, and among healthcare providers who may prescribe PrEP...
November 29, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27898596/pre-exposure-prophylaxis-failure-with-tenofovir-disoproxil
#10
Hendrik Streeck, Jens Verheyen, Julian Storim, Ulf Dittmer, Christoph Jochum, Jörg Timm, Stefan Esser
No abstract text is available yet for this article.
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27898570/are-centers-for-disease-control-and-prevention-guidelines-for-preexposure-prophylaxis-specific-enough-formulation-of-a-personalized-hiv-risk-score-for-pre-exposure-prophylaxis-initiation
#11
Matthew R Beymer, Robert E Weiss, Catherine A Sugar, Linda B Bourque, Gilbert C Gee, Donald E Morisky, Suzanne B Shu, Marjan Javanbakht, Robert K Bolan
BACKGROUND: Preexposure prophylaxis (PrEP) has emerged as a human immunodeficiency virus (HIV) prevention tool for populations at highest risk for HIV infection. Current US Centers for Disease Control and Prevention (CDC) guidelines for identifying PrEP candidates may not be specific enough to identify gay, bisexual, and other men who have sex with men (MSM) at the highest risk for HIV infection. We created an HIV risk score for HIV-negative MSM based on Syndemics Theory to develop a more targeted criterion for assessing PrEP candidacy...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27898566/antiretroviral-therapy-initiation-is-not-associated-with-risky-sexual-behavior-among-heterosexual-human-immunodeficiency-virus-infected-persons-in-serodiscordant-partnerships
#12
Andrew Mujugira, Connie Celum, Kenneth Ngure, Katherine K Thomas, Elly Katabira, Jared M Baeten
BACKGROUND: Few prospective studies have assessed whether antiretroviral therapy (ART) use is associated with changes in sexual risk behavior of human immunodeficiency virus (HIV)-infected persons in known HIV-serodiscordant partnerships. METHODS: We conducted a longitudinal analysis of HIV-infected persons with known uninfected partners enrolled in the Partners Pre-Exposure Prophylaxis Study in Kenya and Uganda. Antiretroviral therapy use and self-reported sexual behavior were ascertained every 3 months...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27898526/uptake-of-hiv-pre-exposure-prophylaxis-prep-in-a-national-cohort-of-gay-and-bisexual-men-in-the-united-states-the-motivational-prep-cascade
#13
Jeffrey T Parsons, H Jonathon Rendina, Jonathan M Lassiter, Thomas H F Whitfield, Tyrel J Starks, Christian Grov
OBJECTIVES: The HIV care cascade provides milestones to track the progress of HIV-positive people from seroconversion through viral suppression. We propose a Motivational PrEP Cascade involving five stages based upon the Transtheoretical Model of Change. METHODS: We analyzed data from 995 men in One Thousand Strong, a longitudinal study of a national panel of HIV-negative gay and bisexual men in the United States. RESULTS: Nearly all (89%) participants were sexually active in the past 3 months, and 65% met CDC criteria for PrEP candidacy...
November 24, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27896552/primary-care-physicians-willingness-to-prescribe-hiv-pre-exposure-prophylaxis-for-people-who-inject-drugs
#14
E Jennifer Edelman, Brent A Moore, Sarah K Calabrese, Gail Berkenblit, Chinazo Cunningham, Viraj Patel, Karran Phillips, Jeanette M Tetrault, Minesh Shah, David A Fiellin, Oni Blackstock
Pre-exposure prophylaxis for HIV (PrEP) is recommended for people who inject drugs (PWID). Despite their central role in disease prevention, willingness to prescribe PrEP to PWID among primary care physicians (PCPs) is largely understudied. We conducted an online survey (April-May 2015) of members of a society for academic general internists regarding PrEP. Among 250 respondents, 74% (n = 185) of PCPs reported high willingness to prescribe PrEP to PWID. PCPs were more likely to report high willingness to prescribe PrEP to all other HIV risk groups (p's < 0...
November 28, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27885972/protecting-the-confidentiality-and-security-of-personal-health-information-in-low-and-middle-income-countries-in-the-era-of-sdgs-and-big-data
#15
Eduard J Beck, Wayne Gill, Paul R De Lay
BACKGROUND: As increasing amounts of personal information are being collected through a plethora of electronic modalities by statutory and non-statutory organizations, ensuring the confidentiality and security of such information has become a major issue globally. While the use of many of these media can be beneficial to individuals or populations, they can also be open to abuse by individuals or statutory and non-statutory organizations. Recent examples include collection of personal information by national security systems and the development of national programs like the Chinese Social Credit System...
2016: Global Health Action
https://www.readbyqxmd.com/read/27885552/prep-awareness-familiarity-comfort-and-prescribing-experience-among-us-primary-care-providers-and-hiv-specialists
#16
Andrew E Petroll, Jennifer L Walsh, Jill L Owczarzak, Timothy L McAuliffe, Laura M Bogart, Jeffrey A Kelly
HIV pre-exposure prophylaxis (PrEP) was FDA approved in 2012, but uptake remains low. To characterize what would facilitate health care providers' increased PrEP prescribing, we conducted a 10-city, online survey of 525 primary care providers (PCPs) and HIV providers (HIVPs) to assess awareness, knowledge, and experience with prescribing PrEP; and, comfort with and barriers to PrEP-related activities. Fewer PCPs than HIVPs had heard of PrEP (76 vs 98%), felt familiar with prescribing PrEP (28 vs. 76%), or had prescribed it (17 vs...
November 24, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27883309/likely-impact-of-pre-exposure-prophylaxis-on-hiv-epidemics-among-men-who-have-sex-with-men
#17
Iryna B Zablotska
Rapid developments in the field of HIV pre-exposure prophylaxis (PrEP) with antiretrovirals offer a promise to bring HIV transmission among gay and other men who have sex with men (MSM) to zero by 2030. This review evaluates studies, which modelled the impact of PrEP on HIV diagnoses, and discusses the progress towards PrEP implementation. Studies in English, conducted after 2010 among MSM in countries of the Organization for Economic Cooperation and Development (OECD) were reviewed. Six modelling studies were included, three of which had been conducted outside the US...
November 25, 2016: Sexual Health
https://www.readbyqxmd.com/read/27880833/prioritizing-risk-in-preparation-for-a-demonstration-project-a-mixed-methods-feasibility-study-of-oral-pre-exposure-prophylaxis-prep-among-female-sex-workers-in-south-india
#18
Sushena Reza-Paul, Lisa Lazarus, Monika Doshi, Syed Hafeez Ur Rahman, Manjula Ramaiah, Raviprakash Maiya, Venugopal Ms, K T Venukumar, Sundar Sundararaman, Marissa Becker, Stephen Moses, Robert Lorway
BACKGROUND: HIV prevalence among female sex workers (FSWs) in India remains well above the national average. Pre-exposure prophylaxis (PrEP), a new HIV prevention technology, may help to reduce HIV incidence, but there is a dearth of research that can inform the potential scale-up of PrEP in India. In partnership with Ashodaya Samithi, a local sex worker collective, we conducted a feasibility study to assess acceptance of a planned PrEP demonstration project, willingness to use PrEP, and recommendations for project roll-out among FSWs in southern Karnataka...
2016: PloS One
https://www.readbyqxmd.com/read/27873082/i-can-see-clearly-now-using-active-visualisation-to-improve-adherence-to-art-and-prep
#19
EDITORIAL
Annie S K Jones, Keith J Petrie
Non-adherence remains a perplexing issue in HIV treatment. After decades of research supporting the efficacy of antiretroviral therapy, non-adherence to medication remains an important issue. For patients who are non-adherent to anti-retroviral therapy (ART), there appears to be a mismatch between their model of illness and the necessity for ART treatment. We propose that 'active visualisation' is a technique that could be utilised to improve understanding of treatment and subsequently adherence for both individuals living with HIV and those at-risk of infection...
November 21, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27873081/awareness-and-acceptability-of-pre-exposure-hiv-prophylaxis-among-men-who-have-sex-with-men-in-baltimore
#20
Susan A Fallon, Ju Nyeong Park, Christine Powell Ogbue, Colin Flynn, Danielle German
This paper assessed characteristics associated with awareness of and willingness to take pre-exposure prophylaxis (PrEP) among Baltimore men who have sex with men (MSM). We used data from BESURE-MSM3, a venue-based cross-sectional HIV surveillance study conducted among MSM in 2011. Multivariate regression was used to identify characteristics associated with PrEP knowledge and acceptability among 399 participants. Eleven percent had heard of PrEP, 48% would be willing to use PrEP, and none had previously used it...
November 21, 2016: AIDS and Behavior
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