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https://www.readbyqxmd.com/read/29048252/stigma-communication-surrounding-prep-the-experiences-of-a-sample-of-men-who-have-sex-with-men
#1
Joseph Schwartz, Josh Grimm
HIV is a serious problem in the USA, particularly for men who have sex with men (MSM). A new means of HIV prevention, called pre-exposure prophylaxis (PrEP), has been shown to be highly effective. However, in spite of earning FDA approval, adoption of PrEP by MSM has been limited. The purpose of this study was to examine the experiences of a sample of 38 MSM who have adopted PrEP, focusing on communication with healthcare providers and social networks. In-depth interviews were used to collect data. Findings revealed that stigmatization by healthcare providers as well as stigmatization by other MSM was a relatively common experience for participants...
October 19, 2017: Health Communication
https://www.readbyqxmd.com/read/29042372/awareness-and-willingness-towards-pre-exposure-prophylaxis-against-hiv-infection-among-individuals-seeking-voluntary-counselling-and-testing-for-hiv-in-taiwan-a-cross-sectional-questionnaire-survey
#2
Yi-Chieh Lee, Sui-Yuan Chang, Kuan-Yin Lin, Lan-Hsin Chang, Wen-Chun Liu, Cheng-Hsin Wu, Hsin-Yun Sun, Chien-Ching Hung, Shan-Chwen Chang
OBJECTIVES: We aimed to investigate the awareness and willingness towards pre-exposure prophylaxis (PrEP) among individuals seeking voluntary counselling and testing (VCT) for HIV in Taiwan, where PrEP is currently not reimbursed by the insurance. METHODS: Between April and October 2016, a questionnaire interview was conducted among VCT clients to inquire about the attitudes towards PrEP against HIV infection. Multivariate logistic regression analysis was performed to identify the associated factors with willingness to initiate PrEP...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29040666/maternal-tenofovir-disoproxil-fumarate-use-during-pregnancy-is-not-associated-with-adverse-perinatal-outcomes-among-hiv-infected-east-african-women-a-prospective-study
#3
Jillian Pintye, Jared M Baeten, Connie Celum, Nelly Mugo, Kenneth Ngure, Edwin Were, Elizabeth Bukusi, Grace John-Stewart, Renee A Heffron
Background: Tenofovir disoproxil fumarate (TDF) is commonly used in antiretroviral treatment (ART) and pre-exposure prophylaxis regimens. We evaluated the relationship between adverse perinatal outcomes and prenatal TDF use. Methods: Longitudinal data were analyzed from HIV-infected women who became pregnant during two HIV prevention studies conducted among HIV-serodiscordant couples in Kenya and Uganda. Pregnancies were included if singleton, not terminated by an induced abortion and had documentation of 3-drug ART use...
October 10, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29039265/hiv-prevention-trial-design-in-an-era-of-effective-pre-exposure-prophylaxis
#4
Amy Cutrell, Deborah Donnell, David T Dunn, David V Glidden, Anneke Grobler, Brett Hanscom, Britt S Stancil, R Daniel Meyer, Ronnie Wang, Robert L Cuffe
Pre-exposure prophylaxis (PrEP) has demonstrated remarkable effectiveness protecting at-risk individuals from HIV-1 infection. Despite this record of effectiveness, concerns persist about the diminished protective effect observed in women compared with men and the influence of adherence and risk behaviors on effectiveness in targeted subpopulations. Furthermore, the high prophylactic efficacy of the first PrEP agent, tenofovir disoproxil fumarate/emtricitabine (TDF/FTC), presents challenges for demonstrating the efficacy of new candidates...
October 17, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/29038726/knowledge-attitudes-and-practices-toward-prevention-of-hepatitis-b-virus-infection-among-medical-students-at-northern-border-university-arar-kingdom-of-saudi-arabia
#5
Mohammed Ali Alhowaish, Jawaher Ali Alhowaish, Yasser Hamoud Alanazi, Muharib Mana Alshammari, Mushref Saeid Alshammari, Nasser Ghadeer Alshamari, Abdulaziz Sael Alshammari, Meshael Kareem Almutairi, Sultan Abdullah Algarni
BACKGROUND AND AIM: Health care workers' risk of occupational exposure to HBV is a chief concern, particularly with young students in the health profession. This study was carried out to assess the knowledge regarding symptoms, risk factors and prevention of hepatitis B virus infection among medical students. METHODS: A cross-sectional study was carried out from November 01, 2016 to May 30, 2017 on medical students at the Northern Border University (Arar, Kingdom of Saudi Arabia)...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29038282/intracellular-tenofovir-diphosphate-and-emtricitabine-triphosphate-in-dried-blood-spots-following-directly-observed-therapy-the-dot-dbs-study
#6
Peter L Anderson, Albert Y Liu, Jose R Castillo-Mancilla, Edward M Gardner, Sharon M Seifert, Cricket McHugh, Theresa Wagner, Kayla Campbell, Mary Morrow, Mustafa Ibrahim, Susan Buchbinder, Lane R Bushman, Jennifer J Kiser, Samantha MaWhinney
Studies of daily emtricitabine-tenofovir disoproxil fumarate (FTC-TDF) for HIV pre-exposure prophylaxis (PrEP) in men who have sex with men (MSM) modeled intracellular tenofovir-diphosphate (TFV-DP) in dried blood spots (DBS) to assess adherence and corresponding PrEP outcomes. We conducted a prospective, randomized, cross-over pharmacokinetic study of TFV-DP in DBS during 33%, 67% or 100% of daily dosing, under directly observed therapy (DOT). Participants were assigned to two 12-week dosing regimens, separated by a 12-week washout...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29030093/estimating-past-inhalation-exposure-to-asbestos-a-tool-for-risk-attribution-and-disease-screening
#7
John W Cherrie, Damien McElvenny, Kevin G Blyth
INTRODUCTION: Late presentation is common in mesothelioma. Reliable assessment of past exposure to asbestos is a necessary first step for risk attribution and for the development of a future screening programme. Such a programme could maximise access to trials of novel therapies and would pave the way for development of novel chemoprophylaxis strategies. This paper describes a method for individual exposure reconstruction along with data from a validation study. METHODS: The exposure assessment method uses only descriptive information about the circumstances of the work that could be obtained from questioning the worker...
October 7, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29028656/costs-and-benefits-of-on-demand-hiv-pre-exposure-prophylaxis-in-men-who-have-sex-with-men-analysis-of-the-anrs-ipergay-study-with-a-one-year-follow-up
#8
Isabelle Durand-Zaleski, Pierre Mutuon, Isabelle Charreau, Cecile Tremblay, Daniela Rojas, Gilles Pialoux, Christian Chidiac, Catherine Capitant, Bruno Spire, Laurent Cotte, Julie Chas, Laurence Meyer
OBJECTIVES: We undertook the economic evaluation of the double-blind randomized ANRS-IPERGAY trial which showed the efficacy of on-demand pre-exposure prophylaxis (PrEP) with tenofovir-disoproxil-fumarate (TDF-FTC) in preventing HIV infection among high risk men-who have-sex-with-men (MSM). DESIGN & METHODS: The economic evaluation was prospective. Counseling, drugs (TDF-FTC at &OV0556;500.88 for 30 tablets), tests, visits and hospital admissions were valued based on in-trial use...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29027392/summary-of-guidelines-for-the-use-of-pre-exposure-prophylaxis-for-hiv-in-korea
#9
REVIEW
(no author information available yet)
There are several guidelines for the use of pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) which are used in other countries. However, the implementation of such guidelines in each country should be modified according to the country's clinical and epidemiological situation. Therefore, The Korean Society for AIDS founded a committee in 2016 to develop guidelines for the use of PrEP for HIV that are optimal for Korea's clinical and epidemiological situation. These guidelines aim to provide comprehensive information for PrEP implementation in Korea...
September 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29026872/top-questions-in-id-pre-exposure-prophylaxis-for-hiv
#10
Douglas S Krakower, Stephanie E Cohen, Kenneth H Mayer
HIV pre-exposure prophylaxis (PrEP) is highly efficacious at preventing HIV acquisition. This review discusses ways to identify candidates for PrEP, recommended PrEP regimens, baseline and follow-up evaluations, applications of PrEP for HIV-serodiscordant couples, resources to address financial barriers, investigational strategies for PrEP, and educational resources for clinicians and patients.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29023141/sexual-identity-disclosure-and-awareness-of-hiv-prevention-methods-among-black-men-who-have-sex-with-men
#11
Ryan J Watson, Jessica N Fish, Aerielle Allen, Lisa Eaton
Black men who have sex with men (BMSM) are disproportionately affected by the human immunodeficiency virus (HIV) epidemic, yet we know little about how HIV-negative BMSM of different sexual orientations access HIV prevention strategies. Identity development, minority stress, and disclosure theories suggest that for people of different sexual orientations, disclosure of sexual identity may be related to health behaviors. We performed a latent class analysis on a sample of 650 BMSM (Mage = 33.78, SD = 11...
October 12, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29019352/hot-news-gene-therapy-with-crispr-cas9-coming-to-age-for-hiv-cure
#12
Vicente Soriano
The huge success of current antiretroviral therapy is mediated by a triple effect: (i) Halting progression to AIDS in infected persons; (ii) reducing the risk of transmission to contacts (treatment as prevention); and (iii) minimizing the risk of HIV acquisition treating uninfected persons at risk (pre-exposure prophylaxis). However, UNAIDS has estimated that only 70% of infected people globally are diagnosed, only 53% are treated, and overall 44% have undetectable viral load, which is the necessary request for ensuring any antiretroviral benefit...
October 11, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28991023/pre-exposure-prophylaxis-for-msm-and-transgender-persons-in-early-adopting-countries
#13
Elske Hoornenborg, Douglas S Krakower, Maria Prins, Kenneth H Mayer
: Pre-exposure prophylaxis (PrEP) is a potent and underutilized HIV prevention tool. In this paper we review the state of knowledge regarding PrEP implementation for men who have sex with men and transgender persons in early adopting countries. We focus on implementation of PrEP in demonstration projects and clinical care, and describe the status of PrEP availability and uptake. We report on approaches to identifying appropriate PrEP candidates in real-world settings and on best practices for clinical monitoring...
October 23, 2017: AIDS
https://www.readbyqxmd.com/read/28986029/daily-and-non-daily-pre-exposure-prophylaxis-in-african-women-hptn-067-adapt-cape-town-trial-a-randomised-open-label-phase-2-trial
#14
Linda-Gail Bekker, Surita Roux, Elaine Sebastien, Ntando Yola, K Rivet Amico, James P Hughes, Mark A Marzinke, Craig W Hendrix, Peter L Anderson, Vanessa Elharrar, Michael Stirratt, James F Rooney, Estelle Piwowar-Manning, Susan H Eshleman, Laura McKinstry, Maoji Li, Bonnie J Dye, Robert M Grant
BACKGROUND: The relative feasibility and acceptability of daily versus non-daily dosing of oral HIV pre-exposure prophylaxis (PrEP) among women are unknown. We aimed to investigate the feasibility of non-daily PrEP regimens in adult women. METHODS: We did a randomised, open-label, phase 2 clinical trial (HPTN 067/ADAPT) of oral PrEP with emtricitabine plus tenofovir disoproxil fumarate at a research centre in Cape Town, South Africa. Participants were adult women (age ≥18 years) who received directly observed dosing once a week for 5 weeks followed by random assignment (1:1:1) at week 6 to one of three unblinded PrEP regimens for self-administered dosing over 24 weeks: daily; time-driven (twice a week plus a post-sex dose); or event-driven (one tablet both before and after sex)...
October 3, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28985573/antibody-based-immunotherapy-of-aciclovir-resistant-ocular-herpes-simplex-virus-infections
#15
Dirk Bauer, Jessica Keller, Mira Alt, Axel Schubert, Ulrich Wilhelm Aufderhorst, Vivien Palapys, Maren Kasper, Christiane Silke Heilingloh, Ulf Dittmer, Björn Laffer, Anna Maria Eis-Hübinger, Georges M Verjans, Arnd Heiligenhaus, Michael Roggendorf, Adalbert Krawczyk
The increasing incidence of aciclovir- (ACV) resistant strains in patients with ocular herpes simplex virus (HSV) infections is a major health problem in industrialized countries. In the present study, the humanized monoclonal antibody (mAb) hu2c targeting the HSV-1/2 glycoprotein B was examined for its efficacy towards ACV-resistant infections of the eye in the mouse model of acute retinal necrosis (ARN). BALB/c mice were infected by microinjection of an ACV-resistant clinical isolate into the anterior eye chamber to induce ARN and systemically treated with mAb hu2c at 24h prior (pre-exposure prophylaxis) or at 24, 40, and 56h after infection (post-exposure immunotherapy)...
October 3, 2017: Virology
https://www.readbyqxmd.com/read/28982311/-wtf-is-prep-attitudes-towards-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-and-transgender-women-in-new-york-city
#16
Matthew Thomann, Ashley Grosso, Richard Zapata, Mary Ann Chiasson
In the USA, gay and other men who have sex with men and transgender women are disproportionately affected by HIV. Uptake of pre-exposure prophylaxis (PrEP), anti-retroviral therapy to prevent HIV-negative individuals from seroconverting if exposed to HIV, by members of this population remains low, particularly among African-Americans. We conducted two focus groups to assess responses to an online social media campaign focusing on PrEP use in New York City. We designed, produced and disseminated the campaign to address knowledge of PrEP; its physical and psychological side effects; and psychosocial barriers related to PrEP adherence and sex shaming...
October 6, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28971705/an-educational-initiative-in-response-to-identified-prep-prescribing-needs-among-pcps-in-the-southern-u-s
#17
Meredith E Clement, Jessica Seidelman, Jiewei Wu, Kareem Alexis, Kara McGee, N Lance Okeke, Gregory Samsa, Mehri McKellar
Pre-exposure prophylaxis (PrEP) is an effective HIV prevention method, but many primary care physicians (PCPs) have not incorporated PrEP into practice. While PrEP may be a key strategy to reducing high HIV transmission rates in the southern US, knowledge about PrEP prescribing patterns among PCPs in this region is lacking. An online survey was sent to a large network of PCPs at an academic medical center in North Carolina in October 2015. The survey was repeated in September 2016, after an educational intervention that included on-site trainings at 14 PCP offices...
October 3, 2017: AIDS Care
https://www.readbyqxmd.com/read/28969696/efficacy-of-rabies-vaccines-in-dogs-and-cats-and-protection-in-a-mouse-model-against-european-bat-lyssavirus-type-2
#18
Tiina Nokireki, Miia Jakava-Viljanen, Anna-Maija Virtala, Liisa Sihvonen
BACKGROUND: Rabies is preventable by pre- and/or post-exposure prophylaxis consisting of series of rabies vaccinations and in some cases the use of immunoglobulins. The success of vaccination can be estimated either by measuring virus neutralising antibodies or by challenge experiment. Vaccines based on rabies virus offer cross-protection against other lyssaviruses closely related to rabies virus. The aim was to assess the success of rabies vaccination measured by the antibody response in dogs (n = 10,071) and cats (n = 722), as well as to investigate the factors influencing the response to vaccination when animals failed to reach a rabies antibody titre of ≥ 0...
October 2, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28967541/minors-and-young-adults-experiences-of-the-research-consent-process-in-a-phase-ii-safety-study-of-pre-exposure-prophylaxis-for-hiv
#19
Amelia S Knopf, Mary A Ott, Nancy Liu, Bill G Kapogiannis, Gregory D Zimet, J Dennis Fortenberry, Sybil G Hosek
PURPOSE: There is a persistent HIV epidemic among sexual and gender minority adolescents in the U.S. Oral pre-exposure prophylaxis (PrEP) is an efficacious prevention strategy, but not yet approved for minors. Minors' access to biomedical HIV prevention technologies is impeded by the ethical and legal complexities of consent to research participation. We explore autonomous consent and study experiences among minor and adult participants in Project PrEPare, a Phase II safety study of PrEP for HIV prevention...
September 26, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28961680/high-prevalence-of-hiv-drug-resistance-among-newly-diagnosed-infants-aged-18-months-results-from-a-nationwide-surveillance-in-nigeria
#20
Seth Chekata Inzaule, Samuels Jay Osi, Gbenga Akinbiyi, Asadu Emeka, Hadiza Khamofu, Rex Mpazanje, Oluwafunke Ilesanmi, Nicaise Ndembi, Solomon Odafe, Kim C E Sigaloff, Tobias F Rinke de Wit, Sulaimon Akanmu
BACKGROUND: The world-health organization recommends protease-inhibitor-based first-line regimen in infants due to risk of drug resistance from failed prophylaxis used in prevention-of-mother-to-child transmission (PMTCT). However cost and logistics impede implementation in sub-Saharan Africa and >75% of children still receive non-nucleoside reverse transcriptase inhibitor-based regimen (NNRTI) used in PMTCT. METHODS: We assessed the national pre-treatment drug resistance prevalence of HIV-infected children <18 months in Nigeria, using the WHO recommended HIV drug resistance surveillance protocol...
September 25, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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