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https://www.readbyqxmd.com/read/28651403/-compliancy-of-pre-exposure-prophylaxis-for-hiv-infection-in-men-who-have-sex-with-men-in-chengdu
#1
J Y Xu, Y C Mou, Y L Ma, J Y Zhang
Objective: To evaluate the compliancy of HIV pre-exposure prophylaxis (PrEP) in men who have sex with men (MSM) in Chengdu, Sichuan province, and explore the influencing factors. Methods: From 1 July 2013 to 30 September 2015, a random, open, multi-center and parallel control intervention study was conducted in 328 MSM enrolled by non-probability sampling in Chengdu. The MSM were divided into 3 groups randomly, i.e. daily group, intermittent group (before and after exposure) and control group. Clinical follow-up and questionnaire survey were carried out every 3 months...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28650381/potential-for-immune-driven-viral-polymorphisms-to-compromise-antiretroviral-based-pre-exposure-prophylaxis-for-prevention-of-hiv-1-infection
#2
Hiroyuki Gatanaga, Zabrina L Brumme, Emily Adland, Gustavo Reyes-Terán, Santiago Avila-Rios, Carlos R Mejía-Villatoro, Tsunefusa Hayashida, Takayuki Chikata, Giang Van Tran, Kinh Van Nguyen, Rita I Meza, Elsa Y Palou, Humberto Valenzuela-Ponce, Juan M Pascale, Guillermo Porras-Cortés, Marvin Manzanero, Guinevere Q Lee, Jeffrey N Martin, Mary N Carrington, Mina John, Simon Mallal, Art F Y Poon, Philip Goulder, Masafumi Takiguchi, Shinichi Oka
OBJECTIVE: Long-acting rilpivirine is a candidate for pre-exposure prophylaxis (PrEP) for prevention of HIV-1 infection. However, rilpivirine resistance mutations at reverse transcriptase codon 138 (RT-E138X) occur naturally in a minority of HIV-1-infected persons; in particular those expressing Human Leukocyte Antigen (HLA)-B*18 where RT-E138X arises as an immune escape mutation. We investigate the global prevalence, B*18-linkage and replicative cost of RT-E138X and its regional implications for rilpivirine PrEP...
June 23, 2017: AIDS
https://www.readbyqxmd.com/read/28650227/facilitators-and-barriers-to-participation-in-prep-hiv-prevention-trials-involving-transgender-male-and-female-adolescents-and-emerging-adults
#3
Celia B Fisher, Adam L Fried, Margaret Desmond, Kathryn Macapagal, Brian Mustanski
Despite the disproportionate burden of HIV facing transgender youth, they continue to be under-represented in studies to provide an empirical basis for pre-exposure prophylaxis (PrEP) programs that can meet the unique needs of this population. This study examined facilitators and barriers to participation in a PrEP adherence study, determined through an online survey administered to 90 transgender male and 60 transgender female 14-21-year-olds attracted to cisgender male sexual partners. Approximately 50% reported likely to participate in the PrEP study...
June 2017: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/28649870/lubricant-provides-poor-rectal-mucosal-hiv-coverage
#4
Eugenie C Shieh, Ethel D Weld, Edward J Fuchs, Hiwot Hiruy, Karen W Buckheit, Robert W Buckheit, Jennifer C Breakey, Craig W Hendrix
Given the rising HIV incidence in men who have sex with men (MSM) despite repeatedly proven effectiveness of oral HIV pre-exposure prophylaxis, behaviorally-congruent periodic dosing strategies, such as dosing microbicides as lubricants, are now in demand. Rectal microbicide gel studies largely administer gels using vaginal applicators, which have not been well-received and do not mimic lubricant use. We compared rectal gel manually dosed as lubricant to applicator dosing in five healthy, HIV-negative MSM who received 10 or 3...
June 25, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28639995/recovery-of-bone-mineral-density-following-discontinuation-of-tenofovir-based-hiv-pre-exposure-prophylaxis
#5
David V Glidden, Kathleen Mulligan, Vanessa McMahan, Peter L Anderson, Juan Guanira, Suwat Chariyalertsak, Susan P Buchbinder, Linda Gail Bekker, Mauro Schechter, Beatriz Grinsztejn, Robert M Grant
BACKGROUND: Oral tenofovir disoproxil fumarate (TDF) for HIV prevention and treatment is associated with decreases in bone mineral density (BMD). Previous reports suggest that these changes may be reversible after discontinuation of TDF. SETTING: A metabolic substudy of 498 participants in a randomized, placebo-controlled HIV prevention trial of oral co-formulated TDF with emtricitabine (TDF/FTC, Truvada®) for HIV preexposure prophylaxis (PrEP) enrolling a global sample of men who have sex with men and trans women...
June 19, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28634661/depression-and-art-initiation-among-hiv-serodiscordant-couples-in-kenya-and-uganda
#6
Jennifer Velloza, Connie Celum, Jessica E Haberer, Kenneth Ngure, Elizabeth Irungu, Nelly Mugo, Jared M Baeten, Renee Heffron
Depression is a known barrier for antiretroviral therapy (ART) adherence, but less is understood about its effects on ART initiation. We followed 1013 HIV-infected individuals participating in the Partners Demonstration Project, an open-label study of integrated pre-exposure prophylaxis (PrEP) and ART delivery for HIV serodiscordant couples in Kenya and Uganda. Associations between depression, measured annually with the Hopkins Symptoms Checklist-Depression (HSCL-D), and ART initiation were assessed with Cox proportional hazards regression...
June 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28634660/should-i-convince-my-partner-to-go-on-pre-exposure-prophylaxis%C3%A2-prep-the-role-of-personal-and-relationship-factors-on-prep-related-social-control-among-gay-and-bisexual-men
#7
Steven A John, Tyrel J Starks, H Jonathon Rendina, Christian Grov, Jeffrey T Parsons
An estimated 35-68% of new HIV infections among gay, bisexual, and other men who have sex with men (GBM) are transmitted through main partnerships. Pre-exposure prophylaxis (PrEP) is highly effective in reducing HIV seroconversion, yet PrEP uptake has been modest. PrEP-naïve GBM with HIV-negative, PrEP-naïve main partners enrolled in One Thousand Strong (n = 409), a U.S. national cohort of GBM, were asked about (1) the importance of partner PrEP use and (2) their willingness to convince their partner to initiate PrEP...
June 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28634155/perceptions-of-hiv-seriousness-risk-and-threat-among-online-samples-of-hiv-negative-men-who-have-sex-with-men-in-seven-countries
#8
Anna N Chard, Nicholas Metheny, Rob Stephenson
BACKGROUND: Rates of new HIV infections continue to increase worldwide among men who have sex with men (MSM). Despite effective prevention strategies such as condoms and pre-exposure prophylaxis (PrEP), low usage of both methods in many parts of the world hinder prevention efforts. An individual's perceptions of the risk of acquiring HIV and the seriousness they afford to seroconversion are important drivers of behavioral risk-taking. Understanding the behavioral factors suppressing the uptake of HIV prevention services is a critical step in informing strategies to improve interventions to combat the ongoing HIV pandemic among MSM...
June 20, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28633387/anal-intercourse-among-female-sex-workers-in-c%C3%A3-te-d-ivoire-prevalence-determinants-and-model-based-estimates-of-the-population-level-impact-on-hiv-transmission
#9
Mathieu Maheu-Giroux, Stefan Baral, Juan F Vesga, Daouda Diouf, Souleymane Diabaté, Michel Alary, Kouamé Abo, Marie-Claude Boily
Current evidence suggests that anal intercourse (AI) during sex work is common in sub-Saharan Africa, but few studies investigated the contribution of heterosexual AI to HIV epidemics. Using a respondent-driven sampling survey of female sex workers (FSW) in Abidjan (2014), we estimated AI prevalence and frequency. Poisson regressions were used to identify AI determinants. About 20% of FSW (N = 466) engaged in AI during a normal week (95% confidence intervals: 15-26%). Women who performed AI were generally younger, had been selling sex for longer, were born in Côte d'Ivoire, reported higher sex-work income, more frequent sex in public places, and violence from clients than women not reporting AI...
June 14, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28631059/trends-in-hiv-risk-testing-and-treatment-among-msm-in-chicago-2004-2014-implications-for-hiv-elimination-planning
#10
Ethan Morgan, Britt Skaathun, Nicola Lancki, Antonio D Jimenez, Jesus Ramirez-Valles, Ramona Bhatia, Stephanie Masiello-Schuette, Nanette Benbow, Nikhil Prachand, John A Schneider
Men who have sex with men (MSM) in the USA continue to have high rates of HIV infection. Increasingly, in addition to behavioral factors, biomedical interventions have been found to play important roles in HIV prevention. In this analysis, we used four waves of cross-sectional data (2004, 2008, 2011, and 2014) from the National HIV Behavioral Surveillance System (NHBS) to examine trends in key behaviors and biomedical interventions among MSM in Chicago (N = 3298). Logistic regression was used to determine changes in behaviors and use of biomedical interventions...
June 19, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28631044/-personalized-treatment-of-viral-hepatitis-of-the-present-and-the-future-hepatitis%C3%A2-b-c-delta-and-e
#11
REVIEW
R Bartenschlager, M Cornberg, T Pietschmann
Precision medicine is also possible for infectious diseases as shown for the treatment of chronic viral hepatitis, especially if different options are available. In hepatitis B virus (HBV) infection, treatment indication as well as the choice of treatment and the decisions to stop treatment are based on viral markers and alanine aminotransferase (ALT) level. Future therapies for HBV infection aiming for functional cure or even virus elimination may be even more personalized and have to take into account the immune status of a given patient...
June 19, 2017: Der Internist
https://www.readbyqxmd.com/read/28616719/are-partner-race-and-intimate-partner-violence-associated-with-incident-and-newly-diagnosed-hiv-infection-in-african-american-men-who-have-sex-with-men
#12
Matthew R Beymer, Nina T Harawa, Robert E Weiss, Chelsea L Shover, Brian R Toynes, Steven Meanley, Robert K Bolan
Black gay, bisexual, and other men who have sex with men (BMSM) experience a disparate rate of HIV infections among MSM. Previous analyses have determined that STI coinfection and undiagnosed HIV infection partly explain the disparity. However, few studies have analyzed the impact of partner-level variables on HIV incidence among BMSM. Data were analyzed for BMSM who attended the Los Angeles LGBT Center from August 2011 to July 2015 (n = 1974) to identify risk factors for HIV infection. A multivariable logistic regression was used to analyze predictors for HIV prevalence among all individuals at first test (n = 1974; entire sample)...
June 14, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28615975/pre-exposure-prophylaxis-for-hiv-prevention-in-women-current-perspectives
#13
REVIEW
Charlene A Flash, Sannisha K Dale, Douglas S Krakower
There are ~900,000 new HIV infections among women every year, representing nearly half of all new HIV infections globally. In the US, nearly one-fifth of all new HIV infections occur among women, and women from racial and ethnic minority communities experience disproportionately high rates of new HIV infections. Thus, there is a need to develop and implement effective HIV prevention strategies for women in the US and internationally, with a specific need to advance strategies in minority communities. Previous studies have demonstrated that oral HIV pre-exposure prophylaxis (PrEP), the use of antiretroviral medications by HIV-uninfected persons to prevent HIV acquisition, can reduce HIV incidence among women who are adherent to PrEP...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28612340/long-acting-systemic-hiv-pre-exposure-prophylaxis-an-examination-of-the-field
#14
REVIEW
William R Lykins, Ellen Luecke, Daniel Johengen, Ariane van der Straten, Tejal A Desai
Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentrations. This is especially true for women, who experience less forgiveness from dose skipping than men in clinical trials of HIV PrEP. There is increasing interest in long-acting (LA), user-independent forms of HIV PrEP that could overcome this adherence challenge...
June 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28604443/differences-in-awareness-of-pre-exposure-prophylaxis-and-post-exposure-prophylaxis-among-groups-at-risk-for-hiv-in-new-york-state-new-york-city-and-long-island-ny-2011-2013
#15
Suzan M Walters, Alexis V Rivera, Lila Starbuck, Kathleen H Reilly, Nyasha Boldon, Bridget J Anderson, Sarah Braunstein
BACKGROUND: Pre-exposure prophylaxis (PrEP) to reduce the risk of HIV was approved in 2012 and post-exposure prophylaxis (PEP) in 2005. We report the differences in awareness of PrEP/PEP and factors associated with awareness by examining 3 risk groups (men who have sex with men (MSM), people who inject drugs, and high-risk heterosexuals). METHODS: National HIV Behavioral Surveillance system data collected in New York City (NYC) and Long Island, NY in 2011-2013 were used...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604442/awareness-willingness-and-use-of-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-in-washington-dc-and-miami-dade-county-fl-national-hiv-behavioral-surveillance-2011-and-2014
#16
Rudy Patrick, David Forrest, Gabriel Cardenas, Jenevieve Opoku, Manya Magnus, Gregory Phillips, Alan Greenberg, Lisa Metsch, Michael Kharfen, Marlene LaLota, Irene Kuo
INTRODUCTION: Despite the effectiveness of oral pre-exposure prophylaxis (PrEP) for HIV prevention, knowledge, and uptake of this new prevention intervention over time has not been fully studied. Using NHBS data from 2 urban areas highly impacted by HIV, we examined awareness, use, and willingness to use daily oral PrEP and factors associated with willingness to take oral PrEP among men who have sex with men (MSM) over time. METHODS: MSM from Washington, DC and Miami, FL were recruited in 2011 and 2014 using venue-based sampling...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28601086/burden-and-characteristics-of-hiv-infection-among-female-sex-workers-in-kampala-uganda-a-respondent-driven-sampling-survey
#17
Wolfgang Hladik, Andrew L Baughman, David Serwadda, Jordan W Tappero, Rachel Kwezi, Namakula D Nakato, Joseph Barker
BACKGROUND: Sex workers in Uganda are at significant risk for HIV infection. We characterized the HIV epidemic among Kampala female sex workers (FSW). METHODS: We used respondent-driven sampling to sample FSW aged 15+ years who reported having sold sex to men in the preceding 30 days; collected data through audio-computer assisted self-interviews, and tested blood, vaginal and rectal swabs for HIV, syphilis, neisseria gonorrhea, chlamydia trachomatis, and trichomonas vaginalis...
June 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28600755/a-review-of-hiv-pre-exposure-prophylaxis-the-female-perspective
#18
REVIEW
Jennifer L Bailey, Suzanne T Molino, Ana D Vega, Melissa Badowski
When taken consistently, pre-exposure prophylaxis (PrEP) against human immunodeficiency virus (HIV) with once daily tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) has been shown to safely reduce the incidence of HIV infection in high-risk individuals by more than 90%. Yet, according to the Centers for Disease Control and Prevention, there were about 2.1 million new cases of HIV reported worldwide in 2015. Undoubtedly, there is significant room for improvement to prevent the transmission of HIV. Research to date has been heavily focused on the high-risk men who have sex with men (MSM) population, yet, many women worldwide remain at high risk of HIV transmission...
June 9, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28597265/-hiv-pre-exposure-prophylaxis-prep-in-men
#19
REVIEW
Christoph D Spinner
No abstract text is available yet for this article.
June 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28597264/-hiv-pre-exposure-prophylaxis-in-women
#20
REVIEW
Annette Haberl
No abstract text is available yet for this article.
June 2017: MMW Fortschritte der Medizin
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