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Lamivudine

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https://www.readbyqxmd.com/read/29329305/evaluating-the-efficacy-of-switching-from-lamivudine-plus-adefovir-to-tenofovir-disoproxil-fumarate-monotherapy-in-lamivudine-resistant-stable-hepatitis-b-patients
#1
Heon Ju Lee, Sang Jin Kim, Young Oh Kweon, Soo Young Park, Jeong Heo, Hyun Young Woo, Jae Seok Hwang, Woo Jin Chung, Chang Hyeong Lee, Byung Seok Kim, Jeong Ill Suh, Won Young Tak, Byoung Kuk Jang
BACKGROUND: The efficacy of switching to tenofovir disoproxil fumarate (TDF) monotherapy from lamivudine (LAM) plus adefovir dipivoxil (ADV) combination therapy (stable switching) in patients with LAM-resistant chronic hepatitis B (CHB) and undetectable hepatitis B virus (HBV) DNA is not clear. METHODS: In this non-inferiority trial, patients with LAM-resistant CHB and undetectable serum HBV DNA (<20 IU/mL) for >6 months after initiating LAM+ADV combination therapy were randomized (1:2) either to continue the combination therapy (LAM+ADV group, n = 58) or switched to TDF monotherapy (TDF group, n = 111)...
2018: PloS One
https://www.readbyqxmd.com/read/29318459/incidence-and-predictors-of-single-drug-discontinuation-according-to-the-presence-of-hcv-coinfection-in-hiv-patients-from-the-icona-foundation-cohort-study
#2
Sebastiano Leone, Milensu Shanyinde, Alessandro Cozzi Lepri, Fiona C Lampe, Pietro Caramello, Andrea Costantini, Andrea Giacometti, Andrea De Luca, Antonella Cingolani, Francesca Ceccherini Silberstein, Massimo Puoti, Andrea Gori, Antonella d'Arminio Monforte
To evaluate incidence rates of and predictors for any antiretroviral (ART) drug discontinuation by HCV infection status in a large Italian cohort of HIV infected patients. All patients enrolled in ICONA who started combination antiretroviral therapy (cART) containing abacavir or tenofovir or emtricitabine or lamivudine plus efavirenz or rilpivirine or atazanavir/r or darunavir/r (DRV/r) or lopinavir/r or dolutegravir or elvitegravir or raltegravir were included. Multivariate Poisson regression models were used to determine factors independently associated with single ART drug discontinuation...
January 9, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29315352/hepatitis-b-infection-among-hiv-infected-individuals-in-gabon-occult-hepatitis-b-enhances-hbv-dna-prevalence
#3
Berthold Bivigou-Mboumba, Marie Amougou-Atsama, Samira Zoa-Assoumou, Hervé M'boyis Kamdem, Guy Francis Nzengui-Nzengui, Angélique Ndojyi-Mbiguino, Richard Njouom, Sandrine François-Souquière
In Gabon, a central African country, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are endemic. In a recent study, conducted in a semi-urban area (Franceville, Gabon), HBV infection was found to be more prevalent among HIV infected individuals. This study aims to investigate the prevalence and genetic diversity of hepatitis B virus infection among HIV infected individuals, predominantly under antiretroviral therapy, living in fully urbanized area: Libreville, capital of Gabon. Serological and molecular tests were performed to detect HBV infection among patients living with HIV/AIDS (PLHA)...
2018: PloS One
https://www.readbyqxmd.com/read/29302757/indinavir-alters-the-pharmacokinetics-of-lamivudine-partially-via-inhibition-of-multidrug-and-toxin-extrusion-protein-1-mate1
#4
Qing Li, Zhi Ye, Peng Zhu, Dong Guo, Hong Yang, Jin Huang, Wei Zhang, James E Polli, Yan Shu
PURPOSE: Lamivudine, a characterized substrate for human multidrug and toxin extrusion protein 1 (hMATE1) in vitro, was commonly used with indinavir as a therapy against human immunodeficiency virus (HIV). We aimed to investigate whether mouse MATE1 is involved in the disposition of lamivudine in vivo, and whether there is any transporter-mediated interaction between indinavir and lamivudine. METHODS: The role of MATE1 in the disposition of lamivudine was determined using Mate1 wild type (+/+) and knockout (-/-) mice...
January 4, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29296098/the-right-combination-treatment-outcomes-among-hiv-positive-patients-initiating-first-line-fixed-dose-antiretroviral-therapy-in-a-public-sector-hiv-clinic-in-johannesburg-south-africa
#5
Kamban Hirasen, Denise Evans, Mhairi Maskew, Ian M Sanne, Kate Shearer, Caroline Govathson, Given Malete, Sheryl A Kluberg, Matthew P Fox
Background: Long-term antiretroviral therapy (ART) adherence is critical for achieving optimal HIV treatment outcomes. Fixed-dose combination (FDC) single-pill regimens, introduced in South Africa in April 2013, has simplified pill taking. We evaluated treatment outcomes among patients initiated on a FDC compared to a similar multi-pill ART regimen in Johannesburg, South Africa. Methods: We conducted a retrospective cohort study of ART-naïve HIV-positive non-pregnant adult (≥18 years) patients without tuberculosis who initiated first-line ART on tenofovir and emtricitabine or lamivudine with efavirenz at Themba Lethu Clinic in Johannesburg, South Africa...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29288943/design-synthesis-and-evaluation-of-novel-phenyl-propionamide-derivatives-as-non-nucleoside-hepatitis-b-virus-inhibitors
#6
Jingying Qiu, Qineng Gong, Jian Gao, Wang Chen, Yinpeng Zhang, Xiaoke Gu, Daoquan Tang
As an ongoing search for potent non-nucleoside anti-HBV agents with novel structures, we described a series of phenyl propionamide derivatives (3a-b, 4a-e, 7a-g, 8a-h and 9a-b) by pharmacophore fusion strategy in the present work. All the compounds exhibited an anti-HBV activity to some extent. Among them, compounds 8d and 9b displayed most potent anti-HBV activity with IC50 values on HBV DNA replication of 0.46 and 0.14 μM, respectively. And the selective index values of 8d and 9b were more than 217.39 and 153...
December 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29288020/long-term-incidence-and-predictors-of-hepatitis-b-surface-antigen-loss-after-discontinuing-nucleoside-analogues-in-non-cirrhotic-chronic-hepatitis-b-patients
#7
Chien-Hung Chen, Chao-Hung Hung, Jing-Houng Wang, Sheng-Nan Lu, Tsung-Hui Hu, Chuan-Mo Lee
OBJECTIVES: This study investigates the long-term incidence and predictors for hepatitis B surface antigen (HBsAg) loss after nucleoside analogue (NA) therapy. METHODS: The study included 411 non-cirrhotic chronic hepatitis B (CHB) patients (148 hepatitis B e antigen (HBeAg)-positive and 263 HBeAg-negative patients) who were treated with lamivudine (n=110) or entecavir (n=301) with post-treatment follow-up of at least 12 months. RESULTS: In HBeAg-positive patients, the 8-year cumulative rates of virological relapse, clinical relapse, and HBsAg loss were 55...
December 26, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29287028/hbv-or-hcv-coinfection-in-hiv-1-infected-pregnant-women-in-france-prevalence-and-pregnancy-outcomes
#8
Valérie Benhammou, Roland Tubiana, Sophie Matheron, Pierre Sellier, Laurent Mandelbrot, Jérôme LE Chenadec, Emmanuelle Marel, Babak Khoshnood, Josiane Warszawski
BACKGROUND: Chronic HBV or HCV infection is frequent in HIV- infected persons but their impact on pregnant HIV-infected women is understudied. We explored whether these coinfections are associated with adverse pregnancy outcomes and lower response to antiretroviral therapy (ART). METHODS: Pregnancies in HIV-1-infected women included in the ANRS French Perinatal Cohort between 2005 and 2013 were analyzed if HBV and HCV infection statuses were available. RESULTS: Among 4236 women, the prevalence of HBV (HBs Ag+) and HCV (RNA+) were 6...
December 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29281889/discovery-of-a-semi-synthesized-cyclolignan-as-a-potent-hiv-1-non-nucleoside-reverse-transcriptase-inhibitor
#9
Jia-Mei Guo, Ming-Yu Ba, Ying Yang, Chun-Suo Yao, Miao Yu, Jian-Gong Shi, Ying Guo
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are essential components of highly active antiretroviral therapy (HAART) for human immunodeficiency virus type 1 (HIV-1) infection. In this study, we identified (+)-(7'S,8S,8'S)-3',4,4',5,5'-pentamethoxy-2,7'-cyclolignan (SG-1), a cyclolignan semi-synthesized from Machilus robusta and M. wangchiana extracts, as a potent NNRTI. SG-1 displayed anti-HIV-1 activity with an IC50 of 0.77 μmol/L by inhibiting reverse transcriptase (RT) RNA-dependent DNA polymerase activity through a direct binding...
December 27, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29281718/the-burden-of-hepatitis-b-virus-hbv-infection-genotypes-and-drug-resistance-mutations-in-human-immunodeficiency-virus-positive-patients-in-northwest-ethiopia
#10
Tekalign Deressa, Debasu Damtie, Kevin Fonseca, Shan Gao, Ebba Abate, Shitaye Alemu, Yetemwork Aleka, Mark G Swain, Guido van Marle, Carla S Coffin
BACKGROUND: In sub-Saharan Africa, the hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections are endemic. Although there has been great progress in HIV care, universal HBV vaccination and care is lacking. In this study, we aimed to determine the prevalence of HBV, HBV genotypes, and drug resistance mutations in dual infected cases in a cohort of HIV patients in Northwest Ethiopia. METHODS: A total of 308 HIV-1 positive patients were enrolled into the study and tested for HBsAg in plasma...
2017: PloS One
https://www.readbyqxmd.com/read/29228565/nucleoside-analogs-treatment-delay-the-onset-of-hepatocellular-carcinoma-in-patients-with-hbv-related-cirrhosis
#11
Jingfeng Bi, Zheng Zhang, Enqiang Qin, Jun Hou, Shuiwen Liu, Zengmin Liu, Shuo Li, Zhenman Wei, Yanwei Zhong
Whether Nucleos(t)ide analogs(NA) treatment can delay the onset of HCC remains unclear. We retrospectively analyzed the clinical data of patients with HBV-related cirrhosis and HCC from 2000 to 2012. Cox proportional hazards model was used to explore the association between NA treatment and postponement of HCC development, the dependent variable was time interval from cirrhosis treatment towards the onset of HCC, and the covariates included age, sex, family history, compensation status at baseline. A total of 1155 HCC patients treated with NAs (n = 528, lamivudine, adefovir, entecavir) and non NA (n = 627) for more than 24 months before the occurrence of HCC were incorporated into the cohort...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227461/population-pharmacokinetics-of-lopinavir-in-severely-malnourished-hiv-infected-children-and-the-effect-on-treatment-outcomes
#12
Moherndran Archary, Helen Mcllleron, Raziya Bobat, Phillip La Russa, Thobekile Sibaya, Lubbe Wiesner, Stefanie Hennig
BACKGROUND: In developing countries, malnutrition remains a common clinical syndrome at antiretroviral treatment (ART) initiation. Physiological changes due to malnutrition and during nutritional recovery could affect the pharmacokinetics of antiretroviral drugs. METHODS: HIV-infected children admitted with severe acute malnutrition were randomised to early or delayed initiation of lopinavir/ritonavir, abacavir and lamivudine using WHO weight-band dosage charts...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29227001/antiviral-therapy-for-hepatitis-b-virus-during-second-pregnancies
#13
Yasuhiro Wakano, Tokio Sugiura, Takeshi Endo, Koichi Ito, Mitsuyoshi Suzuki, Hitoshi Tajiri, Yasuhito Tanaka, Shinji Saitoh
Mother-to-child transmission of the hepatitis B virus (HBV) is a major concern for infected mothers, especially after their first child has become an HBV carrier despite immunoprophylaxis. Eight mothers whose first child had become an HBV carrier despite immunoprophylaxis were referred for antiviral therapy during the subsequent pregnancy. All pregnant women were seropositive for both the hepatitis B surface antigen and hepatitis B e antigen. In the treatment group (three receiving lamivudine and two receiving tenofovir), mother-to-child transmission of the HBV was successfully prevented in all infants (5/5)...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29215820/antiviral-efficacy-of-tenofovir-monotherapy-in-children-with-nucleos-t-ide-naive-chronic-hepatitis-b
#14
Jae Young Choe, Jae Sung Ko, Byung Ho Choe, Jung Eun Kim, Ben Kang, Kyung Jae Lee, Hye Ran Yang
BACKGROUND: The purpose was to compare the efficacy between tenofovir disoproxil fumarate (TDF) and lamivudine (LMV) in children with nucleos(t)ide-naive chronic hepatitis B (CHB) infection. Patients with CHB were treated with TDF in the immune-reactive phase and compared with a historical control group of patients treated with LMV before the TDF era. METHODS: Hepatitis B virus (HBV) DNA titer decrements (> 3 log₁₀ IU/mL) were monitored after treatment initiation...
January 8, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29210336/simplification-to-dual-therapy-containing-lamivudine-and-darunavir-ritonavir-or-atazanavir-ritonavir-in-hiv-infected-patients-on-virologically-suppressive-antiretroviral-therapy
#15
Leonardo Calza, Matteo Cafaggi, Vincenzo Colangeli, Marco Borderi, Enrico Barchi, Massimiliano Lanzafame, Stefano Nicole', Anna Maria Degli Antoni, Isabella Bon, Maria Carla Re, Pierluigi Viale
BACKGROUND: The ritonavir-boosted protease inhibitor (PI/r)-based dual regimens are warranted in order to optimize the combination antiretroviral therapy (cART), prevent the long-term toxicity and reduce the cost of treatments. METHODS: We performed an observational, retrospective study of HIV-infected patients on suppressive antiretroviral therapy who switched to a dual regimen containing lamivudine (3TC) plus darunavir/ritonavir (DRV/r) 800/100 mg qd or atazanavir/ritonavir (ATV/r) 300/100 mg qd...
December 6, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29202874/sensitive-detection-of-hiv-1-resistance-to-zidovudine-and-impact-on-treatment-outcomes-in-low-to-middle-income-countries
#16
Richard M Gibson, Gabrielle Nickel, Michael Crawford, Fred Kyeyune, Colin Venner, Immaculate Nankya, Eva Nabulime, Emmanuel Ndashimye, Art F Y Poon, Robert A Salata, Cissy Kityo, Peter Mugyenyi, Miguel E Quiñones-Mateu, Eric J Arts
BACKGROUND: Thymidine analogs, namely AZT (Zidovudine or Retrovir™) and d4T (Stavudine or Zerit™) are antiretroviral drugs still employed in over 75% of first line combination antiretroviral therapy (cART) in Kampala, Uganda despite aversion to prescribing these drugs for cART in high income countries due in part to adverse events. For this study, we explored how the continued use of these thymidine analogs in cART could impact emergence of drug resistance and impact on future treatment success in Uganda, a low-income country...
December 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29195713/generic-antiretroviral-drug-use-in-hiv-infected-patients-a-cohort-study-from-the-french-health-insurance-database
#17
Joseph Rwagitinywa, Maryse Lapeyre-Mestre, Robert Bourrel, Agnès Sommet
OBJECTIVE: This study aimed to estimate the rate of generic users among HIV-infected patients treated by antiretroviral (ARV) drugs potentially substitutable and to determine factors associated with switch from brand to generic ARV in real-life settings in a French region. METHODS: Cohort of HIV-infected patients aged of ≥18 years, exposed to at least one of the generic of lamivudine (3TC-150mg/300mg), zidovudine/lamivudine (AZT-200mg/3TC-150mg), nevirapine (NVP-200mg), efavirenz (EFV-600mg) and those exposed to brand 3TC, AZT/3TC, NVP, EFV, the fixed-dose combination abacavir/lamivudine (ABC/3TC) or the single-tablet regimen efavirenz/emtricitabine/tenofovir (EFV/FTC/TDF) as recorded in the French health insurance database between January 2012 and May 2015 were included...
November 2, 2017: Thérapie
https://www.readbyqxmd.com/read/29193536/temporal-trend-and-risk-determinants-of-hepatocellular-carcinoma-in-chronic-hepatitis-b-patients-on-entecavir-or-tenofovir
#18
Yao-Chun Hsu, Hsiu-J Ho, Teng-Yu Lee, Yen-Tsung Huang, Ming-Shiang Wu, Jaw-Town Lin, Chun-Ying Wu, Hashem B El-Serag
This study aimed to elucidate the temporal change and determinants for the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B continuously receiving nucleos(t)ide analogues. Through analysis of the national healthcare database in Taiwan, we screened a total of 65,426 infected patients receiving entecavir or tenofovir for at least 3 months and excluded those with lamivudine, adefovir or telbivudine exposure, malignancy, end-stage renal failure, or a diagnosis of HCC within 3 months of starting treatment...
November 28, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29183354/motives-for-change-of-first-line-antiretroviral-therapy-regimens-in-an-unselected-cohort-of-hiv-aids-patients-at-a-major-referral-centre-in-south-west-cameroon
#19
Christian Akem Dimala, Ndemazie Nkafu Bechem, Desmond Aroke, Benjamin Momo Kadia
OBJECTIVE: The rapid scale-up of antiretroviral therapy (ART) coverage in sub-Saharan Africa has encountered the challenge of maintaining international clinical standards of ART utilization and change of ART regimens. In Cameroon, scarce reports have documented the motives for change of ART. This study had as objective to investigate the reasons for switch in ART through a secondary analysis and descriptive synthesis of data from a cross-sectional study at the Limbe Regional Hospital...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29179530/lamivudine-fading-into-the-mists-of-time
#20
Jonggi Choi, Young-Suk Lim
No abstract text is available yet for this article.
November 28, 2017: Clinical and Molecular Hepatology
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