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https://www.readbyqxmd.com/read/29228429/peripheral-blood-cd8-t-cell-profiles-in-patients-with-psoriatic-arthritis-a-cross-sectional-case-control-study
#1
E Colombo, G Galleri, G L Erre, C Piras, G Biondi, L Taras, A Zinellu, A A Mangoni, R Manetti, M Montesu, G Passiu
OBJECTIVE: While CD4+ T-cells are traditionally regarded as the main pathogenic T-cell subpopulation in psoriatic arthritis (PsA), the role of circulating CD8+ T-cells remains poorly characterized. We evaluated the differential representation of CD8+ T-cell subpopulations in peripheral blood (PB) of PsA patients. PATIENTS AND METHODS: CD8+IL-17+, CD8+IFNγ+ and CD8+IL-17-IL-22+ T-cells were evaluated by flow-cytometry in 25 consecutive PsA patients, 7 rheumatoid arthritis (RA) patients, 16 patients with psoriasis, and 26 healthy controls (HC)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29187287/association-between-leptin-and-disease-activity-in-patients-with-rheumatoid-arthritis
#2
José Antonio de Jesús Batún-Garrido, Marisol Salas-Magaña, Isela Esther Juárez-Rojop, Eúfrates Hernández-Núñez, Francisco Olán
BACKGROUND AND OBJECTIVE: Multiple studies have found a direct relationship between leptin concentrations and disease activity in rheumatoid arthritis. PATIENTS AND METHODS: We studied 77 patients with the diagnosis of rheumatoid arthritis; the leptin determination was through an enzyme immunoassay. Disease activity was assessed by the DAS-28 CRP. A multivariate logistic regression model was used to determine the association between significant variables and leptin concentrations...
November 26, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29184984/-charcot-foot-masked-by-erysipelas-and-peripheral-arterial-disease
#3
A Haep, S Murday, A Risse, D Nashan, H F Ständer
Charcot foot is also known as Charcot disease or Charcot arthropathy. The associated aseptic destruction of the bones and joints of the foot results due to peripheral neuropathy accompanied by impaired pain perception, impaired vasomotricity with increased vasodilation, and an unequal weight distribution. Because it is frequently diagnosed late and, thus, incorrectly treated, serious complications often result. An 86-year-old man in poor health was diagnosed with erysipelas of the right foot. The foot was glossy and edematously swollen, showing necrosis of the distal phalanx of the third toe...
November 28, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29181622/neuromuscular-fatigue-is-weakly-associated-with-perception-of-fatigue-and-function-in-patients-with-rheumatoid-arthritis
#4
Rafaela Cavalheiro do Espírito Santo, Marcelo Gava Pompermayer, Rodrigo Rico Bini, Vanessa Olszewski, Elton Gonçalves Teixeira, Rafael Chakr, Ricardo Machado Xavier, Claiton Viegas Brenol
To assess electromyographic parameters of neuromuscular fatigue in knee extensors and their association with clinical, functional and emotional features in patients with rheumatoid arthritis (RA). Thirty-eight female patients with RA participated. Electromyography parameters (changes in signal amplitude, represented by the root mean square, and frequency content, represented by median frequency-MDF) were assessed during a submaximal (60%) isometric contraction of the knee extensors, sustained for 60 s. Clinical characteristics; the 28-joint Disease Activity Score (DAS-28) in which includes count of swollen joints (out of the 28) and tender joints (out of the 28), the erythrocyte sedimentation rate and global disease activity measured on a visual analogue scale; serum C reactive protein (CRP); information on treatment; the Health Assessment Questionnaire; the Functional Assessment of Chronic Illness Therapy fatigue scale (FACIT-F); the Short Form Health Survey (SF-36) and the International Physical Activity Questionnaire (IPAQ), were also assessed...
November 27, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29164814/a-thrombin-receptor-derived-imaging-agent-detects-subclinical-arthritis-in-mice
#5
Beth Friedman, Michael A Whitney, Elamprakash N Savariar, Christa Caneda, Paul Steinbach, Qing Xiong, Dina V Hingorani, Jessica Crisp, Stephen R Adams, Michael Kenner, Csilla N Lippert, Quyen T Nguyen, Monica Guma, Roger Y Tsien, Maripat Corr
OBJECTIVE: Functional imaging of synovitis could improve both early detection of rheumatoid arthritis (RA) and long-term outcomes. Motivated by the intersection of inflammation with coagulation protease activation, we examine coagulation protease activities in arthritic mice with a dual fluorescent Ratiometric thrombin-Activatable Cell Penetrating Peptide (RACPPNleTPRSFL ). METHOD: Mice with chronic transgenic K/BxN arthritis, or with arthritis on Day 1 of passive serum transfer induced arthritis (STIA), were imaged in vivo for Cy5 em: Cy7 em ratiometric fluorescence from proteolytic cleavage and activation of RACPPNleTPRSFL ...
November 22, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29161469/validation-of-a-definition-for-flare-in-patients-with-established-gout
#6
Angelo L Gaffo, Nicola Dalbeth, Kenneth G Saag, Jasvinder A Singh, Elizabeth J Rahn, Amy S Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Sandra Bourke, Worawit Louthrenoo, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana Beatriz Vargas-Santos, Geraldo da Rocha Castelar-Pinheiro, Rodrigo B C Amorim, Till Uhlig, Hilde B Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M McCarthy, Lisa K Stamp, Martijn Gerritsen, Viktoria Fana, Francisca Sivera, William Taylor
OBJECTIVE: To perform external validation of provisional gout flare (attack) definitions in patients with gout. METHODS: We enrolled 509 participants with gout from 17 international sites in a cross-sectional study performed during routine clinical care and collected data to classify participants as experiencing a gout flare or not according to a provisional definition. A local expert rheumatologist performed the final independent adjudication of the gout flare status...
November 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29148421/a-validation-study-of-the-simple-psoriatic-arthritis-screening-sipas-questionnaire-to-screen-psoriasis-patients-for-psoriatic-arthritis
#7
Fausto Salaffi, Marco Di Carlo, Michele Maria Luchetti, Eleonora Di Donato, Anna Campanati, Devis Benfaremo, Massimiliano Nicolini, Marina Carotti, Alfredo Giacchetti, Giulia Ganzetti, Leonardo Bugatti, Armando Gabrielli, Anna Maria Offidani
OBJECTIVES: To validate in a multicentric cohort of patients a self-administered PsA screening tool, called Simple Psoriatic Arthritis Screening (SiPAS) questionnaire, to screen psoriasis patients for signs and symptoms of PsA. METHODS: The SiPAS questionnaire was validated in a multicentric Italian cohort of psoriasis patients referred to two rheumatological centres. RESULTS: A total of 202 psoriasis patients were screened with SiPAS in the validation study...
November 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29148078/soluble-tam-receptor-tyrosine-kinases-in-rheumatoid-arthritis-correlation-with-disease-activity-and-bone-destruction
#8
L Xu, F Hu, H Zhu, X Liu, L Shi, Y Li, H Zhong, Y Su
The TAM receptor tyrosine kinases (TAM RTK) are a subfamily of receptor tyrosine kinases, the role of which in autoimmune diseases such as systemic lupus erythematosus has been well explored, while their functions in rheumatoid arthritis (RA) remain largely unknown. In this study, we investigated the role of soluble TAM receptor tyrosine kinases (sAxl/sMer/sTyro3) in patients with RA. A total of 306 RA patients, 100 osteoarthritis (OA) patients and 120 healthy controls (HCs) were enrolled into this study. The serum concentrations of sAxl/sMer/sTyro3 were measured by enzyme-linked immunosorbent assay (ELISA), then the associations between sAxl/sMer/sTyro3 levels and clinical features of RA patients were analysed...
November 17, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29144558/association-of-oxidative-stress-with-clinical-characteristics-in-patients-with-rheumatoid-arthritis
#9
Sinan Kardeş, Mine Karagülle, İlker Durak, Aslıhan Avcı, Müfit Zeki Karagülle
BACKGROUND: Few studies examining the association between oxidative stress and clinical parameters or disease activity in rheumatoid arthritis (RA) patients are available. Therefore, the objective of this study was to test whether oxidative stress has any association with clinical parameters and disease activity in patients with RA. MATERIALS AND METHODS: In this post hoc cross-sectional study, 45 RA patients treated with traditional disease-modifying antirheumatic drugs (DMARDs) ± low-dose glucocorticoids ± non-steroidal analgesics for at least 3 months were analyzed...
November 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29142032/minimal-disease-activity-as-a-treatment-target-in-psoriatic-arthritis-a-review-of-the-literature
#10
Laure Gossec, Dennis McGonagle, Tatiana Korotaeva, Ennio Lubrano, Eugenio de Miguel, Mikkel Østergaard, Frank Behrens
As in other inflammatory rheumatic diseases, the objective of psoriatic arthritis (PsA) treatment is the achievement of a defined target. Recent recommendations propose aiming for remission or low disease activity; however, a consensual definition of remission is lacking. A state of minimal disease activity (MDA) has been established and is defined by low activity assessed by tender/swollen joint counts, tender entheseal points, Psoriasis Area and Severity Index or body surface area, patient pain and global activity visual analog scale, and functional evaluation by Health Assessment Questionnaire...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29125904/early-rheumatoid-arthritis-presentation-treatment-and-outcomes-in-aboriginal-patients-in-canada-a-canadian-early-arthritis-cohort-study-analysis
#11
Sujay Nagaraj, Cheryl Barnabe, Orit Schieir, Janet Pope, Susan J Bartlett, Gilles Boire, Edward Keystone, Diane Tin, Boulos Haraoui, J Carter Thorne, Vivian P Bykerk, Carol Hitchon
OBJECTIVE: Health inequities exist in chronic diseases for Aboriginal people. This study compared early rheumatoid arthritis (ERA) presentation, treatment and outcomes between Aboriginal and Caucasian patients in a large Canadian cohort study. METHODS: Longitudinal data from the Canadian early ArThritis CoHort (CATCH), a prospective multicenter ERA study, were analyzed for participants who self-identified as Aboriginal or Caucasian ethnicity. Disease characteristics at presentation, prognostic factors, frequency of remission and disease-modifying therapy strategies were contrasted between population groups...
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29123932/hyperphosphatemic-tumoral-calcinosis-after-total-knee-arthroplasty
#12
Takeshi Mochizuki, Katsunori Ikari
We report a case of hyperphosphatemic tumoral calcinosis (TC) that occurred after total knee arthroplasty. A 64-year-old Japanese man presented with painful swellings in both shoulders, the left elbow, and the right hip that developed after he underwent total knee arthroplasty (TKA). The pathology of the patient's bone at the time of TKA included a thick osteoid seam with calcareous deposition at the margin of the trabecular bone, which is not generally seen in osteoarthritis. Computed tomography scans of the swollen joints demonstrated leaflet and amorphous calcification masses around the joints...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29119008/discordant-patient-physician-assessments-of-disease-activity-and-its-persistence-adversely-impact-quality-of-life-and-work-productivity-in-us-hispanics-with-rheumatoid-arthritis
#13
George A Karpouzas, Sera N Ramadan, Chelsie E Cost, Taylor L Draper, Elizabeth Hernandez, Vibeke Strand, Sarah R Ormseth
Objective: This study was designed to evaluate the determinants of patient and physician global assessments (PtGA and MDGA, respectively) of disease activity, their discordance and change over 2 years in Hispanics with rheumatoid arthritis (RA). We further examined the impact of discordance and its persistence on health-related quality of life (HRQOL) and work productivity on final visit. Methods: We studied 536 Hispanics with established RA from a single centre...
2017: RMD Open
https://www.readbyqxmd.com/read/29112187/number-of-circulating-non-classical-cd14-cd16-monocytes-negatively-correlates-with-das28-and-swollen-joints-count-in-peripheral-spondyloarthritis-patients
#14
Zofia Guła, Małgorzata Stec, Magdalena Rutkowska-Zapała, Marzena Lenart, Mariusz Korkosz, Jerzy Gąsowski, Jarosław Baran, Monika Baj-Krzyworzeka, Rafał Szatanek, Jarosław Czyż, Maciej Siedlar
INTRODUCTION    Different clinical course and pattern of skeletal involvement in peripheral (per) and axial (ax) spondyloarthritis (SpA) suggests distinct pathophysiology of these two phenotypic manifestations of SpA. Monocytes, as a part of innate immune system, seem to play an important role in the pathogenesis of SpA, but exact inflammatory pathways remain to be elucidated. Regulatory T lymphocytes (Treg) and Th17 lymphocytes are also known to influence pro- and anti-inflammatory reactions. OBJECTIVES    The aim of our study was to compare absolute numbers of monocyte subpopulations, Treg and Th17 lymphocytes with clinical measures of disease activity in perSpA and axSpA...
November 7, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29108116/arthritis-in-melorheostosis-an-uncommon-feature-in-a-rare-disease
#15
Enrico Selvi, Marco Bardelli, Giacomo Maria Guidelli
A 53-year-old male developed left knee and left ankle arthritis associated with marked induration of the skin and soft tissues distal to the knees. The left knee was swollen, tender, and with a non-reducible contracture and similarly the left ankle and the subtalar joint were stiff and moderately swollen. In addition, diffuse, bluish, small vascular ectasia, hypertrichosis and skin pigmentation of the affected sites were evident (fig1). These symptoms began 20 years before and the patient had been diagnosed with eosinophilic fasciitis and treated with daily prednisone leading to partial improvement of the symptoms, but not of the knee deformity and soft tissue induration...
November 6, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29093159/cnto6785-a-fully-human-antiinterleukin-17-monoclonal-antibody-in-patients-with-rheumatoid-arthritis-with-inadequate-response-to-methotrexate-a-randomized-placebo-controlled-phase-ii-dose-ranging-study
#16
Philip J Mease, Slawomir Jeka, Juan Jose Jaller, Tasanee Kitumnuaypong, Worawit Louthrenoo, Herman Mann, Galina Matsievskaia, Enrique R Soriano, Bin Jia, Caihong Wang, Jing Nie, Elizabeth Hsia
OBJECTIVE: To evaluate the efficacy, safety, pharmacokinetics, and immunogenicity of CNTO6785, a fully human monoclonal antibody that binds to human interleukin 17A, in patients with active rheumatoid arthritis (RA) with inadequate response to methotrexate (MTX) therapy. METHODS: This randomized, double-blind, placebo-controlled, dose-ranging study enrolled patients aged 18 to 80 years (inclusive) with active RA (≥ 6/66 swollen and ≥ 6/68 tender joints) who were refractory to MTX treatment (7...
November 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29080861/ideal-target-for-psoriatic-arthritis-comparison-of-remission-and-low-disease-activity-states-in-a-real-life-cohort
#17
Leonieke J J van Mens, Marleen G H van de Sande, Arno W R van Kuijk, Dominique Baeten, Laura C Coates
BACKGROUND: Psoriatic arthritis (PsA) recommendations state that the target of treatment should be remission or low disease activity (LDA). We used a real-life dataset to compare different potential targets. METHODS: 250 patients with PsA considered in an acceptable disease state according to their rheumatologist were included. Targets for remission were the Disease Activity Index for Psoriatic Arthritis (DAPSA) and clinical DAPSA (cDAPSA) remission (≤4), very low disease activity (VLDA) and Psoriatic Arthritis Disease Activity Score ≤1...
October 28, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29045229/case-247-jersey-finger-of-the-fifth-finger
#18
Viviane Marie Créteur, Pierre François Durieux, Nicolas Cuylits
History A 34-year-old man without underlying medical conditions came to the emergency department for evaluation of persistent pain over the volar portion of his right fifth finger after a fall during a football match 3 days before. At physical examination, the injured finger was swollen and purple. Passive and active flexion of the proximal and distal interphalangeal joints were compromised, without interphalangeal instability. Radiography was performed in the emergency department, and the patient was released with a diagnosis of a fifth digit sprain...
November 2017: Radiology
https://www.readbyqxmd.com/read/29045212/tofacitinib-or-adalimumab-versus-placebo-for-psoriatic-arthritis
#19
RANDOMIZED CONTROLLED TRIAL
Philip Mease, Stephen Hall, Oliver FitzGerald, Désirée van der Heijde, Joseph F Merola, Francisco Avila-Zapata, Dorota Cieślak, Daniela Graham, Cunshan Wang, Sujatha Menon, Thijs Hendrikx, Keith S Kanik
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor that is under investigation for the treatment of psoriatic arthritis. We evaluated tofacitinib in patients with active psoriatic arthritis who previously had an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (DMARDs). METHODS: In this 12-month, double-blind, active-controlled and placebo-controlled, phase 3 trial, we randomly assigned patients in a 2:2:2:1:1 ratio to receive one of the following regimens: tofacitinib at a 5-mg dose taken orally twice daily (107 patients), tofacitinib at a 10-mg dose taken orally twice daily (104), adalimumab at a 40-mg dose administered subcutaneously once every 2 weeks (106), placebo with a blinded switch to the 5-mg tofacitinib dose at 3 months (52), or placebo with a blinded switch to the 10-mg tofacitinib dose at 3 months (53)...
October 19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29041986/fluorescence-optical-imaging-in-pediatric-patients-with-inflammatory-and-non-inflammatory-joint-diseases-a-comparative-study-with-ultrasonography
#20
Marisa Christin Beck, Anne-Marie Glimm, Sarah Ohrndorf, Kirsten Minden, Ralf Trauzeddel, Stephanie Gabriele Werner, Gerd Horneff, Marina Backhaus, Gerd Rüdiger Burmester, Tilmann Kallinich, Hermann Girschick, Jens Klotsche
BACKGROUND: Valid detection of arthritis is essential in differential diagnosis of joint pain. Indocyanin green (ICG)-enhanced fluorescence optical imaging (FOI) is a new imaging method that visualizes inflammation in wrist and finger joints. Objectives of this study were to compare FOI with ultrasonography (US, by gray-scale (GS) and power Doppler (PD)) and clinical examination (CE) and to estimate the predictive power of FOI for discrimination between inflammatory and non-inflammatory juvenile joint diseases...
October 17, 2017: Arthritis Research & Therapy
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