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https://www.readbyqxmd.com/read/28088452/treatment-of-rheumatoid-arthritis-with-combination-of-methotrexate-and-tripterygium-wilfordii-a-meta-analysis
#1
Xiaoyu Wang, Yunyun Zu, Lin Huang, Jie Yu, Huawei Zhao, Chengping Wen, Zhong Chen, Zhenghao Xu
AIMS: Extracts of Tripterygium wilfordii Hook F (TwHF), a traditional Chinese herbal medicine, have been widely used for treating rheumatoid arthritis (RA) in combination with methotrexate (MTX) in China for several decades. However, the efficacy and safety of MTX plus TwHF treatment remain unclear. MAIN METHODS: A comprehensive search of databases in both Chinese and English was performed. Data from the selected studies were extracted and analyzed independently by two authors...
January 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/28072731/focal-segmental-glomerulosclerosis-lagged-behind-the-onset-of-rheumatoid-arthritis-by-7-years-a-case-report-and-literature-review
#2
Yang Liu, Hong-Yan Wen, Li-Hua Wang, Chen Wang
INTRODUCTION: The co-existence of focal segmental glomerulosclerosis (FSGS) and rheumatoid arthritis (RA), presenting either together or in succession, is very rare. A variety of histopathological features in the clinical renal disease may occur in RA. Only 8 studies have previously reported this poorly understood connection. CLINICAL FINDINGS/DIAGNOSES: A case of a 54-year-old male with RA lasting for more than 7 years developed cheirarthritis as the first signs...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28035541/effect-of-artemisia-annua-extract-on-treating-active-rheumatoid-arthritis-a-randomized-controlled-trial
#3
Min Yang, Ming-Yang Guo, Yong Luo, Ming-Dong Yun, Jiao Yan, Tao Liu, Chang-Hong Xiao
OBJECTIVE: To investigate the effect and safety of the complementary use of the extract of Artemisia annua L. (EAA) on treating active rheumatoid arthritis (RA). METHODS: A randomized controlled clinical trial was performed. All the 159 participates with active RA were randomly assigned to the control group (80 cases) and EAA group (79 cases). In the control group, patients were medicated with leflflunomide and methotrexate for 48 weeks; and patients in the EAA group were administrated with leflflunomide, methotrexate plus EAA (30 g/d)...
December 29, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28028155/abatacept-reduces-disease-activity-and-ultrasound-power-doppler-in-acpa-negative-undifferentiated-arthritis-a-proof-of-concept-clinical-and-imaging-study
#4
Maya H Buch, Elizabeth M A Hensor, Chadi Rakieh, Jane E Freeston, Edward Middleton, Sarah Horton, Sudipto Das, Charles Peterfy, Ai Lyn Tan, Richard J Wakefield, Paul Emery
OBJECTIVES: No proven treatment exists for ACPA-negative undifferentiated arthritis (UA). The aim of this study was to evaluate whether abatacept is effective in treating poor prognosis, ACPA-negative UA, including its effect on power Doppler on US (PDUS). METHODS: A proof-of-concept, open-label, prospective study of 20 patients with DMARD-naïve, ACPA-negative UA (⩾2 joint synovitis) and PDUS ⩾ 1 with clinical and 20-joint US (grey scale/PDUS) assessments at baseline, 6, 12, 18 and 24 months...
January 2017: Rheumatology
https://www.readbyqxmd.com/read/28027386/paresis-of-the-peroneal-nerve-a-rare-but-severe-long-term-complication-of-polyethylene-wear-in-knee-arthroplasty
#5
Matthias Aurich, Mark Lenz, Norman Best
One of the most important limiting factors in the long-term success of total knee arthroplasty is polyethylene wear. Particles of the polyethylene inserts have been shown to elicit a foreign body response, which produces bone resorption and osteolysis, ultimately leading to loosening and component failure. The authors report on a case of an elderly patient who underwent a total knee arthroplasty almost 2 decades ago. Clinical and radiological checkups of the knee had not been performed recently. He now presented with a painful and swollen knee, recurrent joint effusion and swelling of the lower leg, and paresis of the peroneal nerve...
December 27, 2016: Orthopedics
https://www.readbyqxmd.com/read/28026736/-peripheral-factures-of-the-talus-mid-term-results
#6
M Peml, P Kálal, P Kopačka, M Kloub
PURPOSE OF THE STUDY Peripheral fractures of the talus (lateral talar process and posterior talar process) are rare injuries, easy to miss on examination due to their location and clinical manifestation. They account for 0.3% to 1.0% of all fractures of the talus. An incorrect or late treatment of talar process fractures can result in permanent pain, impingement syndrome, healing in malposition, pseudoarthrosis development and also, due to joint instability, in a potential development of severe subtalar arthritis...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28013433/correlation-between-rapid-3-das28-cdai-and-sdai-as-a-measure-of-disease-activity-in-a-cohort-of-colombian-patients-with-rheumatoid-arthritis
#7
Jesus Giovanny Ballesteros Muñoz, Rodrigo B Giraldo, Ana M Santos, Juan Manuel Bello-Gualteros, Juan C Rueda, Eugenia-Lucia Saldarriaga, Jose-Ignacio Angarita, Sofia Arias-Correal, Andres Y Vasquez, John Londono
The objective of this study is to correlate the patient-driven tool Routine Assessment of Patient Index Data 3 (RAPID-3) with other common tools used in daily practice to measure disease activity in rheumatoid arthritis (RA).One hundred nineteen RA patients according to 1987 American College of Rheumatology criteria who consecutively attended a RA outpatient clinic between August and December 2015 were evaluated. Data was stored in an electronic form that included demographic information, comorbidities, concomitant medication, and laboratory results...
December 24, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/28012569/efficacy-of-methylprednisolone-acetate-versus-triamcinolone-acetonide-intra-articular-knee-injection-in-patients-with-chronic-inflammatory-arthritis-a-24-week-randomized-controlled-trial
#8
Ashwani Kumar, Varun Dhir, Shefali Sharma, Aman Sharma, Surjit Singh
PURPOSE: Triamcinolone hexacetonide (TH), triamcinolone acetonide (TA), and methylprednisolone acetate (MPA) are commonly used intra-articular steroid preparations. Studies suggest that intra-articular TH is more efficacious than MPA and TA in chronic inflammatory arthritis. However, it is unclear which of the latter two preparations has better efficacy. Thus, we compared intra-articular knee injections of MPA and TA in patients with chronic inflammatory arthritis. METHODS: This double-blind, randomized controlled trial included patients with rheumatoid arthritis or spondyloarthritis with an acutely swollen knee joint (≥1 week, <24 weeks)...
December 21, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/28004828/analysis-of-cxcr5-th17-cells-in-relation-to-disease-activity-and-tnf-inhibitor-therapy-in-rheumatoid-arthritis
#9
Deepika Singh, Matthew Henkel, Bernadette Sendon, June Feng, Anthony Fabio, Diana Metes, Larry W Moreland, Mandy J McGeachy
Th17 and TfH cells are thought to promote tissue inflammation and autoantibody production, respectively, in autoimmune diseases including rheumatoid arthritis (RA). TfH cells that co-express Th17 markers (CXCR5(+)Th17) encompass both of these pathogenic functions, and are increased in some human autoimmune settings including juvenile dermatomyositis. We investigated CXCR5(+)Th17 cells in RA subjects with stable or active disease and before and after TNF inhibitor therapy. CXCR5(+)Th17 cell frequency was increased in RA compared to healthy controls, but other helper T cell subsets were not different...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28002334/gender-differences-among-patients-with-primary-ankylosing-spondylitis-and-spondylitis-associated-with-psoriasis-and-inflammatory-bowel-disease-in-an-iberoamerican-spondyloarthritis-cohort
#10
Margarita Landi, Hernán Maldonado-Ficco, Rodolfo Perez-Alamino, José A Maldonado-Cocco, Gustavo Citera, Pablo Arturi, Percival D Sampaio-Barros, Diana E Flores Alvarado, Rubén Burgos-Vargas, Elena Santos, Daniel Palleiro, Miguel A Gutiérrez, Elsa Vieyra-Sousa, Fernando Pimentel-Santos, Sergio O Paira, Alberto Berman, Claudia Vera Barrezueta, Janitzia Vazquez-Mellado, Eduardo Collantes-Estevez
The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by X or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27995382/latitude-gradient-influences-the-age-of-onset-of-rheumatoid-arthritis-a-worldwide-survey
#11
(no author information available yet)
The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint)...
December 19, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27992958/impaired-akt-phosphorylation-in-monocytes-of-patients-with-rheumatoid-arthritis
#12
Krista Kuuliala, Antti Kuuliala, Mari Hämäläinen, Riitta Koivuniemi, Hannu Kautiainen, Eeva Moilanen, Heikki Repo, Marjatta Leirisalo-Repo
It has been proposed that the Akt kinase pathway provides a regulatory mechanism to limit the inflammatory response. We examined the activation of Akt upon LPS challenge in monocytes of patients with rheumatoid arthritis (RA), and correlated it with disease activity. Twelve subjects with recent-onset, DMARD-naïve RA, thirteen patients with chronic, DMARD therapy -nonresponding RA and 27 healthy volunteers provided whole blood samples for phosphospecific flow cytometric measurement of unstimulated and LPS-stimulated Akt phosphorylation at serine 473 in monocytes, determined in relative fluorescence units (RFU)...
December 19, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27988813/cardiovascular-risk-assessment-in-patients-with-rheumatoid-arthritis-a-correlative-study-of-noninvasive-arterial-health-testing
#13
Erin M Scanlon, Rekha Mankad, Cynthia S Crowson, Iftikhar J Kullo, Sharon L Mulvagh, Eric L Matteson, Zoran Kvrgic, John M Davis
This study aimed to determine the relationship between noninvasive measures of arterial health and both estimated 10-year cardiovascular risk and measures of disease activity over time in established rheumatoid arthritis. Fifty rheumatoid arthritis patients underwent noninvasive arterial health testing (brachial artery reactivity, aortic augmentation index [AIx], pulse wave velocity, carotid artery intima-media thickness, and carotid artery plaque presence) and assessment of clinical disease activity (tender or swollen joint counts, Clinical Disease Activity Index [CDAI], and Health Assessment Questionnaire II [HAQ-II])...
December 17, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27986512/influence-of-periodontal-treatment-on-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#14
Débora Cerqueira Calderaro, Jôice Dias Corrêa, Gilda Aparecida Ferreira, Izabela Guimarães Barbosa, Carolina Castro Martins, Tarcília Aparecida Silva, Antônio Lúcio Teixeira
OBJECTIVE: To evaluate the influence of periodontal treatment on rheumatoid arthritis activity. METHODS: MEDLINE/PUBMED, The Cochrane Library, Clinical Trials, SciELO and LILACS were searched for studies published until December 2014. Included articles were: prospective studies; including patients older than 18 years, diagnosed with periodontitis and rheumatoid arthritis submitted to non-surgical periodontal treatment; with a control group receiving no periodontal treatment; with outcomes including at least one marker of rheumatoid arthritis activity...
November 26, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27974101/response-to-methotrexate-predicts-long-term-mortality-of-patients-with-rheumatoid-arthritis-independent-of-the-degree-of-response-results-of-a-re-evaluation-30-years-after-baseline
#15
Carolin Krause, Gertraud Herborn, Juergen Braun, Henrik Rudolf, Siegfried Wassenberg, Rolf Rau, Dietmar Krause
OBJECTIVES: To assess if there is a correlation between the degree of response to treatment with methotrexate (MTX) and long-term mortality in a cohort of patients with rheumatoid arthritis (RA) established in Germany in the early eighties. METHODS: RA patients who had started MTX treatment between 1980 and 1987 were included. One year after baseline, the treatment response was evaluated. Responders were defined as patients with at least 20% decline in the swollen joint count (out of 32 joints) and the ESR with a prednisone dosage <5 mg/day...
December 13, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27974097/in-early-inflammatory-polyarthritis-more-intensive-management-according-to-2010-acr-eular-criteria-leads-to-higher-rates-of-clinical-remission-comparison-of-two-cohorts-treated-according-to-different-treat-to-target-protocols
#16
Silvia Balduzzi, Carlo Alberto Scirè, Garifallia Sakellariou, Francesca Benaglio, Serena Bugatti, Carlomaurizio Montecucco, Roberto Caporali
OBJECTIVES: The aim of this study was to compare the 12-month probability of remission in early inflammatory arthritis with a milder treatment based on the 1987 criteria or a more intensive protocol based on the 2010 criteria. METHODS: Patients with rheumatoid arthritis (RA) or undifferentiated arthritis (UA) (2005-2012) were included. Before October 2010, patients fulfilling the 1987 criteria received methotrexate (MTX) and possibly low-dose prednisone, while UA hydroxychloroquine (HCQ) (1987-driven cohort)...
December 13, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27964757/discordant-inflammation-and-pain-in-early-and-established-rheumatoid-arthritis-latent-class-analysis-of-early-rheumatoid-arthritis-network-and-british-society-for-rheumatology-biologics-register-data
#17
Daniel F McWilliams, Eamonn Ferguson, Adam Young, Patrick D W Kiely, David A Walsh
BACKGROUND: Rheumatoid arthritis (RA) disease activity is often measured using the 28-joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant with respect to self-reported and objective disease state, with potentially different clinical needs. METHODS: Data were derived from three cohorts: (1) the Early Rheumatoid Arthritis Network (ERAN) and the British Society for Rheumatology Biologics Register (BSRBR), (2) those commencing tumour necrosis factor (TNF)-α inhibitors and (3) those using non-biologic drugs...
December 13, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27957720/-99m-tc-labelled-s-hynic-certolizumab-pegol-in-rheumatoid-arthritis-and-spondyloarthritis-patients-a-biodistribution-and-dosimetry-study
#18
Bieke Lambert, Philippe Carron, Yves D'Asseler, Klaus Bacher, Filip Van den Bosch, Dirk Elewaut, Gust Verbruggen, Rudi Beyaert, Caroline Dumolyn, Filip De Vos
BACKGROUND: Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (CZP), a commercially available humanized Fab'-fragment directed against TNF. A biodistribution and dosimetry study was conducted. Tc-S-HYNIC CZP was synthesized. The in vitro TNF neutralizing activity was tested by exposing L929s-cells to various concentrations 99mTc-S-HYNIC CZP and measuring TNF-induced cytotoxicity...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27956846/repository-corticotropin-injection-in-patients-with-refractory-psoriatic-arthritis-a-case-series
#19
Alan N Brown
PURPOSE: Although numerous treatment options are available for patients with psoriatic arthritis (PsA), a need for effective and tolerable treatments remains for patients with refractory disease who have failed previous therapies and continue to experience tender and/or swollen joints, pain, and disease activity. Repository corticotropin injection (RCI) is believed to produce steroidogenic, steroid-independent, anti-inflammatory, and immunomodulatory effects in patients with rheumatic disorders, such as PsA...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27941198/-clinical-and-ultrasound-assessment-of-the-disease-activity-in-patients-with-rheumatoid-arthritis
#20
Bożena Targońska-Stępniak, Mariusz Piotrowski, Robert Zwolak, Maria Majdan
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease, leading to irreversible joint destruction and deformities. The adequate assessment of the disease activity enables the correct choice of therapy and evaluation of the treatment efficacy. The aim of the study was to compare different methods of assessment of the disease activity, using clinical data and ultrasonography (US) of joints, in patients with RA, in daily clinical practice. MATERIAL AND METHODS: The study group consisted of 68 patients with RA...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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