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https://www.readbyqxmd.com/read/28544615/suppressing-inflammation-in-rheumatoid-arthritis-does-patient-global-assessment-blur-the-target-a-practice-based-call-for-a-paradigm-change
#1
Ricardo J O Ferreira, Cátia Duarte, Mwidimi Ndosi, Maarten de Wit, Laure Gossec, J A P da Silva
OBJECTIVES: In current management paradigms of Rheumatoid Arthritis (RA), patient global assessment (PGA) is crucial to decide whether a patient has attained remission (target) or needs reinforced therapy. We investigated whether the clinical and psychological determinants of PGA are appropriate to support this important role. METHODS: This was a cross-sectional, single centre study including consecutive ambulatory RA patients. Data collection comprised swollen (SJC28) and tender joint counts (TJC28), C-Reactive protein (CRP), PGA, pain, fatigue, function, anxiety, depression, happiness, personality traits, and comorbidities...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28541484/residual-disease-activity-in-psoriatic-arthritis-discordance-between-the-rheumatologist-s-opinion-and-minimal-disease-activity-measurement
#2
Leonieke J J van Mens, Maureen C Turina, Marleen G H van de Sande, Mike T Nurmohamed, Arno W R van Kuijk, Dominique L P Baeten
Objective.: To assess how many PsA patients with an acceptable disease state according to the treating rheumatologist have quiescent disease defined as minimal disease activity (MDA). Methods.: This cross-sectional study included 250 PsA patients. To assess current clinical practice as closely as possible, acceptable disease state was not determined by predefined activity measures, but instead was defined by asking rheumatologists to refer those patients whom they considered sufficiently treated...
May 24, 2017: Rheumatology
https://www.readbyqxmd.com/read/28536825/intramuscular-clodronate-in-erosive-osteoarthritis-of-the-hand-is-effective-on-pain-and-reduces-serum-comp-a-randomized-pilot-trial-the-er-o-d-e-study-erosive-osteoarthritis-and-disodium-clodronate-evaluation
#3
Gianantonio Saviola, Lul Abdi-Ali, Maria Rosaria Povino, Lorella Campostrini, Silvano Sacco, Luca Dalle Carbonare
We evaluated the efficacy and safety of intramuscular clodronate (CLO) for the treatment of active erosive osteoarthritis of the hand (EOA). Forty outpatients treated with anti-inflammatory (NSAIDs) or analgesic drugs since at least 6 months, for at least 3 days a week, were randomly divided into two groups. Group A: 24 patients treated for 6 months with intramuscular (i.m.) CLO added to usual NSAIDs or analgesic drugs. The attack dose was 200 mg/day i.m. for 10 days followed by a maintenance dose of CLO i...
May 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28535896/influence-of-periodontal-treatment-on-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#4
Débora Cerqueira Calderaro, Jôice Dias Corrêa, Gilda Aparecida Ferreira, Izabela Guimarães Barbosa, Carolina Castro Martins, Tarcília Aparecida Silva, Antônio Lúcio Teixeira
OBJECTIVE: To evaluate the influence of periodontal treatment on rheumatoid arthritis activity. METHODS: MEDLINE/PUBMED, The Cochrane Library, Clinical Trials, SciELO and LILACS were searched for studies published until December 2014. Included articles were: prospective studies; including patients older than 18 years, diagnosed with periodontitis and rheumatoid arthritis submitted to non-surgical periodontal treatment; with a control group receiving no periodontal treatment; with outcomes including at least one marker of rheumatoid arthritis activity...
May 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28534758/engineering-tissues-to-heal-themselves-bioinks-and-tendon-scaffolds-show-promise-for-helping-the-body-recover-from-musculoskeletal-injury
#5
Sarah Campbell
Sufferers of osteoarthritis are all too aware of the daily pain and impairment of swollen joints, of having to give up sports-and jobs-due to cartilage defects. What they may be less aware of is that three-dimensional (3-D) bioprinting and bioink technologies are being developed to revolutionize the existing (and often imperfect) treatments available to them.
May 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28532573/global-assessments-of-disease-activity-are-age-dependent-determinant-factors-of-clinical-remission-in-rheumatoid-arthritis
#6
Hideki Ito, Takehisa Ogura, Ayako Hirata, Sayaka Takenaka, Kennosuke Mizushina, Yuki Fujisawa, Takaharu Katagiri, Norihide Hayashi, Hideto Kameda
OBJECTIVE: The aim of the study is to assess the factors associated with clinical remission of patients with rheumatoid arthritis (RA) in daily clinical practice. METHODS: This analysis was based on the data of 304 RA patients in our center between May 2014 and March 2015. The following information was included: tender, swollen, and symptomatic joint counts, patient's and physician's global assessments, functional disability, laboratory and radiographic data, and RA treatments received...
April 28, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28516887/tenosynovitis-in-rheumatoid-arthritis-patients-on-biologic-treatment-involvement-and-sensitivity-to-change-compared-to-joint-inflammation
#7
Hilde Berner Hammer, Tore K Kvien, Lene Terslev
OBJECTIVES: Extensor carpi ulnaris (ECU) and tibialis posterior (TP) tendons are often involved in RA and the present aim was to examine by ultrasound (US) their frequency of inflammation and sensitivity to change in comparison to joint involvement as well as clinical examinations. METHODS: US, clinical and laboratory assessments were performed when starting biologic DMARD (bDMARD) and after 1, 2, 3, 6 and 12 months including bilateral grey-scale (GS) and power Doppler (PD) semi-quantitatively (0-3) scoring of ECU and TP tendons and 18 joints...
May 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28510734/predictors-of-and-outcomes-following-orthopaedic-joint-surgery-in-patients-with-early-rheumatoid-arthritis-followed-for-20-years
#8
James M Gwinnutt, Deborah P M Symmons, Alexander J MacGregor, Jacqueline R Chipping, Chloe Lapraik, Tarnya Marshall, Mark Lunt, Suzanne M M Verstappen
Objectives.: To analyse predictors and outcomes of major orthopaedic surgery in a cohort of RA patients followed for 20 years. Methods.: Patients were recruited to the Norfolk Arthritis Register from 1990 to 1994. Demographic and clinical variables (including the HAQ and swollen and tender joint counts) were assessed at baseline; the 2010 ACR/EULAR RA classification criteria were applied. Patients reported incident comorbidities and major orthopaedic joint surgery (replacement, synovectomy, fusion, excision) when reassessed at years 1, 2, 3, 5, 7, 10, 15 and 20...
May 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28494788/comprehensive-analysis-of-treatment-response-phenotypes-in-rheumatoid-arthritis-for-pharmacogenetic-studies
#9
Kristopher A Standish, C Chris Huang, Mark E Curran, Nicholas J Schork
BACKGROUND: An individual patient's response to a particular drug is influenced by multiple factors, which may include genetic predisposition. Pharmacogenetic studies attempt to discover and estimate the contributions of genetic variants to the variability in response to a drug treatment. The task of identifying the genetic contribution is often complicated by response phenotypes that are based on imprecise or subjective clinical observations. Because the success of a pharmacogenetic study depends on the analysis of a heritable phenotype, it is important to identify phenotypes with a significant heritable component to ensure reliable and reproducible results in subsequent genetic association studies...
May 12, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28469936/ultrasound-detectable-grey-scale-synovitis-predicts-future-fulfilment-of-the-2010-acr-eular-ra-classification-criteria-in-patients-with-new-onset-undifferentiated-arthritis
#10
Sarah C Horton, Ai Lyn Tan, Richard J Wakefield, Jane E Freeston, Maya H Buch, Paul Emery
OBJECTIVE: To determine the clinical outcomes for patients with new-onset undifferentiated arthritis (UA), not fulfilling the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) classification criteria, and the clinical and imaging predictors of disease progression in these patients. METHODS: A prospective observational study was conducted in treatment-naïve UA patients. Baseline ultrasound involved semiquantitative assessment of grey scale (GS) synovitis and power Doppler activity (PD) at 26 joints...
2017: RMD Open
https://www.readbyqxmd.com/read/28464888/functional-disability-associated-with-disease-and-quality-of-life-parameters-in-chinese-patients-with-rheumatoid-arthritis
#11
Juan Ji, Lijuan Zhang, Qiuxiang Zhang, Rulan Yin, Ting Fu, Liren Li, Zhifeng Gu
BACKGROUND: As an important outcome measure among rheumatoid arthritis (RA) patients, functional disability may contribute to unemployment, loss of work productivity, and impaired quality of life. However, little is known about the risk factors of functional disability in Chinese RA patients. This study aimed (1) to examine the prevalence of functional disability in Chinese RA patients; (2) to explore factors associated with the health assessment questionnaire-disability index (HAQ-DI)...
May 2, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28460018/evaluation-of-the-diagnostic-accuracy-of-hand-and-foot-mri-for-early-rheumatoid-arthritis
#12
Wouter P Nieuwenhuis, Hanna W van Steenbergen, Lukas Mangnus, Elize C Newsum, Johan L Bloem, Tom W J Huizinga, Saskia le Cessie, Monique Reijnierse, Annette H M van der Helm-van Mil
Objectives.: To assess the diagnostic value of MRI for early RA. In some RA patients, a classifiable diagnosis cannot be made at first presentation; these patients present with unclassified arthritis (UA). The use of MRI for early diagnosis of RA is recommended, yet the evidence for its reliability is limited. Methods.: MRI of hand and foot was performed in 589 early arthritis patients included in the Leiden Early Arthritis Clinic (229 presented with RA, 159 with other arthritides and 201 with UA)...
April 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28457097/evaluation-of-the-effect-of-h%C3%A3-v%C3%A3-z-mud-in-patients-with-hand-osteoarthritis-a-randomized-controlled-single-blind-follow-up-study
#13
Noémi Gyarmati, Ágota Kulisch, András Németh, Annamária Bergmann, József Horváth, Zsuzsanna Mándó, Ágnes Matán, Erika Szakál, Tímea Sasné Péter, Dóra Szántó, Tamás Bender
BACKGROUND: Heat therapy is one of the most popular non-pharmacological treatments for osteoarthritis of the hand. OBJECTIVES: To investigate the therapeutic and chemical effects of Hévíz mud on patients with hand osteoarthritis. METHODS: We randomly assigned 47 patients with mild-to-moderate hand osteoarthritis to two groups. Patients in group 1 (n=23) received Hévíz mud applied directly to both hands, whereas patients in group 2 (n=24) also received mud to both hands, but nylon gloves separated the skin from the mud...
March 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28451869/contribution-of-subjective-disease-activity-score-28-das28-components-to-the-response-to-treatment-of-rheumatoid-arthritis
#14
Kyeong Min Son, Sung Yeon Lee, Young Il Seo, Ji-Eun Choi, Hyun Ah Kim
We investigated the contributions made by the subjective components of the Disease Activity Score 28 (DAS28) to the treatment response of rheumatoid arthritis (RA). In addition, factors associated with poor response to treatment at 6 months, despite normalization of objective measures, were examined. A total of 426 newly diagnosed RA patients were included. The DAS28-P score (the subjective components of the DAS28 relative to the total components) was calculated as DAS28-P = 0.56 ∗ sqrt(TJC28) + 0...
April 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28446212/doctors-preferences-in-de-escalating-dmards-in-rheumatoid-arthritis-a-discrete-choice-experiment
#15
T Martijn Kuijper, Riëtte Folmer, Elly A Stolk, Johanna M W Hazes, Jolanda J Luime
BACKGROUND: Current guidelines suggest reduction of DMARDs can be considered in RA patients in remission. Objectives were (1) to estimate the relative importance of patient characteristics rheumatologists consider in their decision to de-escalate (2) to assess whether heterogeneity exists among rheumatologists with respect to de-escalation and (3) to identify the preferred de-escalation strategy. METHODS: A discrete choice experiment (DCE) was conducted. All rheumatologists and trainees in The Netherlands were invited to participate...
April 26, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28442212/effects-of-underwater-ultrasound-therapy-on-pain-inflammation-hand-function-and-quality-of-life-in-patients-with-rheumatoid-arthritis-a-randomized-controlled-trial
#16
Márta Király, Zsuzsanna Varga, Ferenc Szanyó, Rita Kiss, Katalin Hodosi, Tamás Bender
OBJECTIVES: To investigate the effects of underwater ultrasound (US) therapy in 48 patients with moderately active rheumatoid arthritis (disease activity score in 28 joints [DAS28]>3.2 and<5.1). METHODS: Patients randomly assigned to the ultrasound group (n=25) received underwater continuous ultrasound therapy to both wrists and hands for 7min per session with an intensity of 0.7W/cm(2) for 10 sessions. The control group (n=23) received sham treatment under the same conditions...
April 13, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28432523/hypothesis-free-analyses-from-a-large-psoriatic-arthritis-cohort-support-merger-to-consolidated-peripheral-arthritis-definition-without-subtyping
#17
Daniel Stekhoven, Almut Scherer, Michael J Nissen, Véronique Grobéty, Nikhil Yawalkar, Peter M Villiger, Burkhard Möller
Current ClASsification criteria for Psoriatic ARthritis classification criteria for psoriatic arthritis (PsA) provide a preliminary definition of inflammatory articular disease. This study aimed to further characterize PsA peripheral arthritis using purely data-driven approaches for the affected joint distribution pattern. PsA patients from the Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) database were clustered according to similarities in 66 swollen and in 68 tender joints. Clusters were compared in terms of other disease characteristics and studied for coincidence with traditional PsA subtypes, stability over time and treatment response upon first tumour necrosis factor alpha (TNF-α) therapy...
April 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28425173/the-20-year-outcome-and-association-between-early-treatment-and-mortality-and-disability-in-an-inception-cohort-of-patients-with-rheumatoid-arthritis-results-from-the-norfolk-arthritis-register
#18
James M Gwinnutt, Deborah Pm Symmons, Alexander J MacGregor, Jacqueline R Chipping, Tarnya Marshall, Mark Lunt, Suzanne Mm Verstappen
Objective - To describe the outcome of patients with rheumatoid arthritis (RA) over 20 years from symptom onset; to assess the association between early treatment (DMARDs/steroids) and mortality and disability over follow-up. Methods - Patients from the Norfolk Arthritis Register recruited from 1990-94 who met the 2010 ACR/EULAR RA criteria at baseline were included in this analysis. Demographic/clinical variables were collected at baseline and years 1-3, 5, 7, 10, 15 and 20. Disease activity (swollen/tender joint counts (SJC/TJC)), disability (HAQ) and mortality over 20 years are described...
April 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28413222/calcium-pyrophosphate-deposition-disease-in-the-ankle-joint-a-case-report
#19
Brynne E Stainsby, Nadine Ellul, Angelica Dimopoulos, Caitlin Lubberdink, Vanessa Salerno, Michelle Solomon
OBJECTIVE: To detail the presentation of calcium pyrophosphate deposition disease (CPPD) in the ankle joint. The aim of this case report is to inform health-care practitioners about the presentation of this condition in an uncommon location and discuss the diagnosis, potential treatment, and management strategies for a patient with CPPD. CLINICAL FEATURES: A 36-year-old male patient presented to a chiropractic clinic with an acute, painful, and swollen ankle, which was later diagnosed by plain film radiograph as CPPD...
March 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28412709/the-association-of-low-income-with-functional-status-and-disease-burden-in-german-patients-with-rheumatoid-arthritis-results-of-a-cross-sectional-questionnaire-survey-based-on-claims-data
#20
Johanna Callhoff, Andres Luque Ramos, Angela Zink, Falk Hoffmann, Katinka Albrecht
OBJECTIVE: To assess the influence of income on self-reported disease and work productivity outcomes. METHODS: Persons with rheumatoid arthritis (RA) diagnosis (International Classification of Diseases, 10th ed. codes M05/M06) on health insurance claims data in at least 2 quarters of 2013 were randomly selected. They were mailed questionnaires covering RA diagnosis, household income, functional capacity [Hannover functional status questionnaire (FFbH), 0-100], RA Impact of Disease questionnaire (RAID; 0-10), self-reported swollen joint count (SJC; 0-48), tender joint count (TJC; 0-50), and effect of RA on work productivity (change of work, fewer working hours, sick leave, application for disability pension, and others)...
April 15, 2017: Journal of Rheumatology
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