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https://www.readbyqxmd.com/read/29652792/influence-of-blue-mussel-mytilus-edulis-intake-on-disease-activity-in-female-patients-with-rheumatoid-arthritis-the-mira-randomized-cross-over-dietary-intervention
#1
Helen M Lindqvist, Inger Gjertsson, Tove Eneljung, Anna Winkvist
Rheumatoid Arthritis (RA) is a chronic inflammatory disease. This study evaluates the effect of blue mussel intake on disease activity and quality of life in women with RA. Thirty-nine women with established RA and a disease activity score 28 (DAS28) >3.0 were recruited to a randomized 2 × 11-week cross-over dietary intervention. The participants continued with their medication and habitual diet and exchanged one cooked meal a day, five days a week, with a meal including 75 g blue mussels or 75 g meat...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29652702/microwave-radiometry-derived-thermal-changes-of-small-joints-as-additional-potential-biomarker-in-rheumatoid-arthritis-a-prospective-pilot-study
#2
George Pentazos, Katerina Laskari, Kleanthis Prekas, John Raftakis, Petros P Sfikakis, Elias Siores
OBJECTIVE: A prospective pilot study was performed using microwave radiometry (MR), a noninvasive method detecting in-depth tissue temperature, to evaluate whether temperature-of-small-joint-derived scores correlate to parameters commonly used to assess disease activity in rheumatoid arthritis (RA). METHODS: Ten patients with active, untreated RA underwent clinical and laboratory assessments and joint ultrasound and MR of hand and foot small joints at baseline and at 15, 30, and 90 days after treatment onset...
April 13, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29624625/clinical-management-of-seronegative-and-seropositive-rheumatoid-arthritis-a-comparative-study
#3
Sang-Tae Choi, Kwang-Hoon Lee
Both rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) are associated with poor radiologic outcomes in patients with rheumatoid arthritis (RA). In general, RA patients positive for RF or ACPA (SPRA) are considered to manifest an aggressive disease course compared with seronegative RA patients (SNRA). However, the relationship between seropositivity and measures of disease severity other than radiologic outcome is disputed. In this study, we sought to compare the clinical presentations and treatment outcomes of SNRA and SPRA patients...
2018: PloS One
https://www.readbyqxmd.com/read/29623279/-clostridium-difficile-colitis-leading-to-reactive-arthritis-a-rare-complication-associated-with-a-common-disease
#4
Asghar Marwat, Hassan Mehmood, Ali Hussain, Muzammil Khan, Asad Ullah, Medha Joshi
The relationship between reactive arthritis and enteric infections caused by Yersinia enterocolitica, Campylobacter jejuni , and Salmonella typhimurium is well documented. Clostridium difficile colitis is a less recognized cause of reactive arthritis. We present a case of a 58-year-old woman with Clostridium difficile colitis complicated by reactive arthritis. A 58-year-old woman with no significant past medical history presented to our hospital with complaints of nonbloody watery diarrhea, abdominal pain for the past 1 week, and right knee pain starting 1 day prior...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29602164/the-impact-of-patient-global-assessment-in-the-definition-of-remission-as-a-predictor-of-long-term-radiographic-damage-in-patients-with-rheumatoid-arthritis-protocol-for-an-individual-patient-data-meta-analysis
#5
Ricardo J O Ferreira, Paco M J Welsing, Laure Gossec, Johannes W G Jacobs, Pedro M Machado, Mwidimi Ndosi, Désirée van der Heijde, José A P da Silva
BACKGROUND: Remission is the target for management of rheumatoid arthritis (RA) and intensification of immunosuppressive therapy is recommended for those that do not achieve this status. Patient global assessment (PGA) is the single patient reported outcome considered in the American College of Rheumatology/European League Against Rheumatism remission criteria, but its use as target has been questioned. The primary aim of this study is to assess whether excluding PGA from the definition of disease remission changes the association of disease remission with long-term radiographic damage and physical function in patients with RA...
January 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29600668/-minimally-invasive-therapy-for-hallux-valgus-with-deformity-of-little-toe-varus
#6
Shi-Wei Gu, Ke Yang, Si-Qiao Zhao, Zhan-Ao Gao, Shun-Qian Ma, Wen-Qing Zhang
OBJECTIVE: To explore clinical effect of minimally corrective osteotomy for the treatment of hallux valgus with deformity of little toe varus through small incision. METHODS: From January 2013 to June 2016, 168 hallux valgus patients with deformity of little toe varus were treated by minimally corrective osteotomy through small incision. Among them, 7 males and 161 females were aged from 22 to 75 years old with an average of(59.3±3.5) years old. Preoperative clinical manifestation mainly focus on red and swollen of bunion, pain around with metatarsal bones, and diagnosed as hallux valgus with deformity of little toe varus through small incision...
March 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29575737/the-impact-of-ultrasound-on-the-use-and-efficacy-of-intra-articular-glucocorticoid-injections-in-early-rheumatoid-arthritis-secondary-analyses-from-the-randomised-arctic-trial
#7
Lena B Nordberg, Siri Lillegraven, Anna-Birgitte Aga, Joe Sexton, Elisabeth Lie, Hilde B Hammer, Inge C Olsen, Till Uhlig, Désirée van der Heijde, Tore K Kvien, Espen A Haavardsholm
OBJECTIVE: Intra-articular glucocorticoid injections are common in rheumatoid arthritis (RA) treatment. We aimed to investigate whether ultrasound in combination with clinical examination is better at identifying joints that will benefit from intra-articular injections compared to identification by clinical examination alone, as well as the efficacy of ultrasound-guided versus palpation-guided procedures. METHODS: In the treat-to-target ARCTIC trial, early RA patients were randomised 1:1 to follow-up with or without ultrasound...
March 25, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29567561/medical-image-analysis-of-knee-joint-lipoma-arborescens-and-arthroscopic-treatment
#8
Guangyu Zhu, Xiangdong Tian, Dongfeng Du, Ming Lei, Lei Guan, Jian Wang, Yetong Tan, Chen Yang, Xinxin Zheng
OBJECTIVE: Arthroscopy is a minimally invasive surgical procedure on a joint in which examination and treatment of knee damage is performed using a surgical device known as the arthroscope. Lipoma arborescens (LA), an infrequent intra-articular lesion, originates from mature adipose cells under subsynovial tissue. The synovial membrane is pale yellow with large villous projections. It is caused by various underlying factors. We found many patients with LA and processed them appropriately...
January 12, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29555896/talar-neck-fracture-with-dislocation-combined-with-bimalleolar-ankle-fracture-a-case-report
#9
Ahmad M Radaideh, Ziad A Audat, Abdullah A Saleh
BACKGROUND Fractures of the talus are uncommon injuries that usually involve the talar neck, rather than the talar body. This report is of a rare case of combined left talar neck fracture and adjacent joint dislocation with an ipsilateral bimalleolar ankle fracture. CASE REPORT A 37-year-old man presented with an injury to his left foot following a motor vehicle accident. When he presented to the hospital emergency department, his left foot and ankle were swollen, the overlying skin was intact but badly contused, and there was no neurovascular deficit...
March 20, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29540195/traditional-chinese-medicine-formula-bi-qi-capsule-alleviates-rheumatoid-arthritis-induced-inflammation-synovial-hyperplasia-and-cartilage-destruction-in-rats
#10
Kai Wang, Dongmei Zhang, Yan Liu, Xuan Wang, Jiantong Zhao, Tingting Sun, Tingting Jin, Baoli Li, Janak L Pathak
BACKGROUND: Traditional Chinese medicine (TCM) formula Bi-Qi capsule (Bi-Qi) is a commonly prescribed drug to treat rheumatoid arthritis (RA). However, the mechanism of Bi-Qi-mediated amelioration of RA pathogenesis is still a mystery. Collagen induced arthritis (CIA) in rats is an established model that shares many similarities with RA in humans. In this study we investigated the effect of Bi-Qi on the pathogenesis of CIA in rats. METHODS: CIA was developed in Sprague-Dawley (S...
March 14, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29521247/evaluating-the-effect-of-oral-n-acetylcysteine-as-an-adjuvant-treatment-on-clinical-outcomes-of-patients-with-rheumatoid-arthritis-a-randomized-double-blind-clinical-trial
#11
Minoo Batooei, Ahmad Tahamoli Roudsari, Zahra Basiri, Fatemeh Yasrebifar, Maryam Shahdoust, Azadeh Eshraghi, Maryam Mehrpooya, Sara Ataei
OBJECTIVE: Oxidative stress and Overproduction of pro-inflammatory cytokines are contributed in rheumatoid arthritis (RA) pathogenesis. N-acetylcysteine (NAC) is an antioxidant and anti-inflammatory agent which demonstrated analgesic effects in some studies. This study is designed to assess the effects of oral NAC as an adjuvant therapy on the clinical symptoms of patients with active RA. METHODS: In this randomized clinical trial, 51 RA patients with active RA were studied in 2 groups, NAC group (27 patients) received standard treatment of RA and 600 mg NAC twice a day for 12 weeks and placebo group (24 patients) received the standard treatment of RA and placebo...
March 7, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29513931/a-randomized-double-blind-parallel-group-placebo-controlled-multiple-dose-study-to-evaluate-amg-557-in-patients-with-systemic-lupus-erythematosus-and-active-lupus-arthritis
#12
Laurence E Cheng, Zahir Amoura, Benjamin Cheah, Falk Hiepe, Barbara A Sullivan, Lei Zhou, Gregory E Arnold, Wayne H Tsuji, Joan T Merrill, James B Chung
OBJECTIVE: Evaluate the safety and potential efficacy of AMG 557, a fully human antibody directed against the inducible T-cell costimulator ligand (ICOSL), in patients with systemic lupus erythematosus (SLE) with arthritis. METHODS: In this phase 1b, randomized, double-blind, placebo-controlled study, patients received AMG 557 210 mg (n=10) or placebo (n=10) weekly for 3 weeks, then every other week for 10 additional doses. Corticosteroids were tapered to ≤7...
March 7, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29509563/relationship-between-health-related-quality-of-life-and-patient-acceptable-symptom-state-with-disease-activity-and-functional-status-in-patients-with-ankylosing-spondylitis-in-thailand-a-cross-sectional-study
#13
Praveena Chiowchanwisawakit, Phakhamon Thaweeratthakul, Luksame Wattanamongkolsil, Varalak Srinonprasert, Ajchara Koolvisoot, Chayawee Muangchan, Surasak Nilganuwong, Emvalee Arromdee, Wanruchada Katchamart
OBJECTIVE: This study aimed to identify factors associated with EuroQoL-5 Dimensions, 5 Levels and Patient Acceptable Symptom State (PASS) and also to estimate health utility (HU) in Thai patients with ankylosing spondylitis (AS). METHODS: This was a cross-sectional study of consecutive AS patients visiting Siriraj Hospital between May 31, 2012, and March 31, 2016. Demographic data and outcomes related to HU (Thai version of EuroQoL-5 Dimensions, 5 Levels), disease activity (Bath Ankylosing Spondylitis Disease Activity Index, Ankylosing Spondylitis Disease Activity Score-erythrocyte sedimentation rate or Ankylosing Spondylitis Disease Activity Score-C-reactive protein, number of tender and swollen joints, and enthesitis), and functional status (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire) were collected...
March 6, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29475855/have-the-10-year-outcomes-of-patients-with-early-inflammatory-arthritis-improved-in-the-new-millennium-compared-with-the-decade-before-results-from-the-norfolk-arthritis-register
#14
James M Gwinnutt, Deborah P M Symmons, Alexander J MacGregor, Jacqueline R Chipping, Tarnya Marshall, Mark Lunt, Suzanne M M Verstappen
OBJECTIVE: To compare the 10-year outcome (disease activity, disability, mortality) of two cohorts of patients with inflammatory polyarthritis (IP) recruited 10 years apart. METHODS: Patients with IP were recruited to the Norfolk Arthritis Register from 1990 to 1994 (cohort 1 (C1)) and from 2000 to 2004 (cohort 2 (C2)). Demographic and clinical data were collected at baseline and at years 1, 2, 3, 5, 7 and 10. Longitudinal disease activity (swollen/tender 51 joint counts (SJC51/TJC51)) and disability (Health Assessment Questionnaire (HAQ)) were compared between the cohorts using population-average negative binomial regression and generalised estimating equation analysis, respectively...
February 23, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29475170/a-case-report-of-anterior-cruciate-ligament-and-posterolateral-corner-reconstruction-using-tendon-graft-preserved-in-situ
#15
Bosco Mpatswenumugabo, Emmanuel Bukara, Muhammed Semakula, Albert Nzayisenga, Rene Mukezamfura, Lambert Dusingizimana, Basile Habumugisha, Salvador Kamarampaka, Leon Mutesa, Alex Butera
INTRODUCTION: Combined anterior cruciate ligament (ACL) and posterolateral corner (PLC) reconstruction are a rare clinical entity in orthopedic literature, whose management requires different types of tendon grafts. Missed PLC injury leads to the failure of ACL repair due to the joint instability. PRESENTATION OF CASE: We are presenting a case of posttraumatic right ACL, PLC and lateral meniscus injury. The patient was taken to theatre for arthroscopic meniscectomy, ACL and PLC reconstruction...
February 17, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29471516/optical-spectral-transmission-to-assess-inflammation-in-hand-and-wrist-joints-of-rheumatoid-arthritis-patients
#16
Nick J Besselink, Patricia van der Meijde, Wouter H J Rensen, Peter B L Meijer, Anne C A Marijnissen, Jacob M van Laar, Floris P J G Lafeber, Johannes W G Jacobs
Objective: To develop an optical spectral transmission (OST) model to measure joint inflammation, and thus disease activity, as well as to evaluate (patho-)physiological findings that could lead to misclassification of inflammation. Methods: Forty-six RA patients were included in this cross-sectional study, where US scores, duplicate OST measurements and 28-joint DAS (DAS28) were acquired. With US as a reference standard, the diagnostic performance of OST in detecting inflammation at the joint level was evaluated using receiver operating characteristic (ROC) curve analyses...
February 19, 2018: Rheumatology
https://www.readbyqxmd.com/read/29470738/prevalence-and-type-ii-diabetes-associated-factors-in-psoriatic-arthritis
#17
Rubén Queiro, Andrés Lorenzo, Estefanía Pardo, Anahy Brandy, Pablo Coto, Javier Ballina
Diabetes is a common cardiovascular risk factor in psoriatic arthritis (PsA). Although the prevalence of diabetes is high, the factors associated with it in PsA are poorly understood. We aimed to analyse the prevalence of type II diabetes and diabetes-associated factors in a hospital-based population with PsA. This cross-sectional study included 340 consecutive patients attended in a tertiary care hospital. The prevalence of diabetes was compared to that of 600 outpatients without inflammatory conditions. To analyse diabetes-associated factors, odds ratio (OR) values were calculated by conditional logistic regression analysis...
February 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29468339/residual-disease-activity-in-rheumatoid-arthritis-patients-treated-with-subcutaneous-biologic-drugs-that-achieved-remission-or-low-disease-activity-a-longitudinal-observational-study
#18
Fabio Massimo Perrotta, Antonia De Socio, Silvia Scriffignano, Ennio Lubrano
The aim of this study was to evaluate the residual disease activity (RDA) and function in rheumatoid arthritis (RA) patients treated with subcutaneous biologic drugs that achieved a status of remission and low disease activity (LDA) according to the various indices validated for RA and to explore the factors associated with RDA. We consecutively enrolled RA patients that started a new subcutaneous biologic treatment. At baseline and after 3 and 6 months of treatment, we assessed the rate of patients that achieved remission or LDA using the Disease Activity Score on 28 joints, Clinical Disease Activity Index, Simplified Disease Activity Index, and American College of Rheumatology/European League Against Rheumatism remission criteria...
February 21, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29466690/safety-and-efficacy-of-etanercept-methotrexate-combination-therapy-in-patients-with-rhupus-an-observational-study-of-non-glucocorticoid-treatment-for-rheumatic-diseases
#19
Bei-Bei Yang, Hua Xiao, Xiao-Jie Li, Min Zheng
OBJECTIVES: To evaluate the safety and efficacy of etanercept (ETN) plus methotrexate (MTX) in patients with rhupus without using corticosteroids. METHODS: Twenty rhupus patients [meeting the criteria for both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)] who had never been treated with corticosteroids, DMARDs, or biological agents with a 28-joint Disease Activity Score (DAS28) >3.2 and lupus nephritis determined from histopathological specimens were enrolled...
January 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29454670/ultrasonography-and-detection-of-subclinical-joints-and-tendons-involvements-in-systemic-lupus-erythematosus-sle-patients-a-cross-sectional-multicenter-study
#20
Carine Salliot, Amélie Denis, Emmanuelle Dernis, Vincent Andre, Aleth Perdriger, Jean-David Albert, Saloua Mammou Mraghni, Isabelle Griffoul-Espitalier, Mohamed Hamidou, Benoit Le Goff, Sandrine Jousse Joulin, Thierry Marhadour, Christophe Richez, Nicolas Poursac, Estebaliz Lazaro, Stéphanie Rist, Anca Corondan, Clara Quinten, Virginie Martaillé, Antoine Valéry, Emilie Ducourau
OBJECTIVES: The aims of this study in SLE population were 1) to describe ultrasonography (US) joint abnormalities, 2) to estimate the reliability of clinical swollen joint count (C-SJC) and SLEDAI (C-SLEDAI) versus US-SJC and US-SLEDAI scores, 3) to highlight specific patterns of lupus patients with Power Doppler (PD) abnormalities. METHOD: For this cross-sectional multicenter study, 151 consecutive adult SLE patients were recruited. Evaluation included a clinical standardized joint assessment, B-mode and PD US of 40 joints and 26 tendons blinded for clinical examination...
February 15, 2018: Joint, Bone, Spine: Revue du Rhumatisme
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