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https://www.readbyqxmd.com/read/29454670/ultrasonography-and-detection-of-subclinical-joints-and-tendons-involvements-in-systemic-lupus-erythematosus-sle-patients-a-cross-sectional-multicenter-study
#1
Carine Salliot, Amélie Denis, Emmanuelle Dernis, Vincent Andre, Aleth Perdriger, Jean-David Albert, Saloua Mammou Mraghni, Isabelle Griffoul-Espitalier, Mohamed Hamidou, Benoit Le Goff, Sandrine Jousse Joulin, Thierry Marhadour, Christophe Richez, Nicolas Poursac, Estebaliz Lazaro, Stéphanie Rist, Anca Corondan, Clara Quinten, Virginie Martaillé, Antoine Valéry, Emilie Ducourau
OBJECTIVES: The aims of this study in SLE population were 1) to describe ultrasonography (US) joint abnormalities, 2) to estimate the reliability of clinical swollen joint count (C-SJC) and SLEDAI (C-SLEDAI) versus US-SJC and US-SLEDAI scores, 3) to highlight specific patterns of lupus patients with Power Doppler (PD) abnormalities. METHOD: For this cross-sectional multicenter study, 151 consecutive adult SLE patients were recruited. Evaluation included a clinical standardized joint assessment, B-mode and PD US of 40 joints and 26 tendons blinded for clinical examination...
February 15, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29447376/the-relationship-between-depression-and-biologic-treatment-response-in-rheumatoid-arthritis-an-analysis-of-the-british-society-for-rheumatology-biologics-register
#2
Faith Matcham, Rebecca Davies, Matthew Hotopf, Kimme L Hyrich, Sam Norton, Sophia Steer, James Galloway
Objective: To investigate the relationship between depressive symptoms and treatment response and disease activity in RA over a 1-year follow-up. Methods: Data from the British Society for Rheumatology Biologics Register were used, representing 18 421 RA patients receiving biologic treatment. Depressive symptoms were identified through one of three assessments: reporting a history of depression, the Medical Outcomes Survey 36-item Short Form or the EuroQol, five-dimension scale...
February 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29443754/multiple-extra-articular-synovial-cysts-accompanied-by-rheumatoid-arthritis-in-the-bilateral-elbow-joints-a-case-report
#3
Jingfeng Zhang, Junli Wang, Xiongwei Mao, Zhengang Li
RATIONALE: Synovial cysts are well known in rheumatoid arthritis (RA), and most common in the popliteal fossa. They may produce lots of local symptoms and complaints, which may present initially as an unrelated clinical condition. Few studies have reported multiple extra-articular synovial cysts (MESCs) in the RA patients. Early diagnosis is crucial for patient treatment. PATIENT CONCERNS: A 50-year-old man without any special clinical histories found a soya bean size bump at the left elbow medially, then multiple lumps were found at bilateral elbows and gradually increasing...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29435630/ct-assessment-of-axillary-lymphadenopathy-in-patients-with-rheumatoid-arthritis-association-with-disease-activity-and-severity
#4
Mizue Hasegawa, Fumikazu Sakai, Naoko Konda, Asako Okabayashi, Hideki Katsura, Yohei Seto
BACKGROUND: Axillary lymph nodes (ALNs) are often seen on chest computed tomography (CT) in rheumatoid arthritis (RA) patients. Early reports described lymphadenopathy as one of the systemic manifestations rather than regional lymphadenopathy secondary to drainage from the affected joints. Subsequently, the importance of the immunological events occurring in draining lymph nodes in the development of arthritis was documented. OBJECTIVE: To identify the relationships of local disease activity and background characteristics, including systemic disease activity, systemic disease activity, with axillary lymphadenopathy (AL) in RA using CT...
February 12, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29427176/satisfaction-with-subcutaneous-golimumab-and-its-auto-injector-among-rheumatoid-arthritis-patients-with-inadequate-response-to-adalimumab-or-etanercept
#5
Raphael J Dehoratius, Lawrence H Brent, Jeffrey R Curtis, Lorie A Ellis, Kezhen L Tang
BACKGROUND: Patient perceptions of treatment success, including satisfaction/preference, may complement clinical efficacy assessments. OBJECTIVE: Our objective was to evaluate satisfaction with subcutaneous golimumab and its auto-injector in patients with rheumatoid arthritis (RA) and an inadequate adalimumab/etanercept response. METHODS: In the multicenter, assessor-blinded GO-SAVE study, 433 patients with active RA (28-joint Disease Activity Score incorporating erythrocyte sedimentation rate [DAS28-ESR] ≥ 3...
February 9, 2018: Patient
https://www.readbyqxmd.com/read/29343507/early-and-sustained-efficacy-with-apremilast-monotherapy-in-biological-na%C3%A3-ve-patients-with-psoriatic-arthritis-a-phase-iiib-randomised-controlled-trial-active
#6
Peter Nash, Kamal Ohson, Jessica Walsh, Nikolay Delev, Dianne Nguyen, Lichen Teng, Juan J Gómez-Reino, Jacob A Aelion
OBJECTIVE: Evaluate apremilast efficacy across various psoriatic arthritis (PsA) manifestations beginning at week 2 in biological-naïve patients with PsA. METHODS: Patients were randomised (1:1) to apremilast 30 mg twice daily or placebo. At week 16, patients whose swollen and tender joint counts had not improved by ≥10% were eligible for early escape. At week 24, all patients received apremilast through week 52. RESULTS: Among 219 randomised patients (apremilast: n=110; placebo: n=109), a significantly greater American College of Rheumatology 20 response at week 16 (primary outcome) was observed with apremilast versus placebo (38...
January 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29342473/effectiveness-of-early-adalimumab-therapy-in-psoriatic-arthritis-patients-from-reuma-pt-early-psa
#7
Helena Santos, Mónica Eusébio, Joana Borges, Diana Gonçalves, Pedro Ávila-Ribeiro, Daniela Santos Faria, Carina Lopes, João Rovisco, Ana Águeda, Patrícia Nero, Paula Valente, Ana Rita Cravo, Maria José Santos
Objective To compare outcomes in psoriatic arthritis (PsA) patients initiating adalimumab (ADA), with short- and long-term disease duration and to evaluate the potential effect of concomitant conventional synthetic disease-modifying antirheumatic drugs (csDMARD) or glucocorticoids. Methods Analyses included adult PsA patients registered in the Rheumatic Diseases Portuguese Register (Reuma.pt) between June 2008-June 2016 who received ADA for ≥3 months. Psoriatic Arthritis Response Criteria (PsARC) response, tender and swollen joint count, inflammatory parameters, patient (PtGA) and physician global assessment (PhGA), Disease Activity Score-28 joints (DAS28), and Health Assessment Questionnaire Disability Index (HAQ-DI) were compared between patients with <5 years of disease (early PsA) and those with ≥5 years of disease duration (late PsA)...
October 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29338586/association-of-cxcl13-serum-level-and-ultrasonographic-findings-of-joints-in-patients-with-systemic-lupus-erythematosus-and-jaccoud-s-arthropathy
#8
D Sá Ribeiro, C F Lins, V Galvão, W G Dourado Santos, G Rosa, V Machicado, A L Pedreira, E P da Fonseca, A P Mota Duque Souza, C Baleeiro, L G Ferreira, I Silva de Oliveira, J P Cotrim Gama da Silva, A M Atta, M B Santiago
Objectives The objective of this paper is to perform an ultrasonography (US) analysis of hands and wrists in two groups of patients with systemic lupus erythematosus (SLE), with and without Jaccoud's arthropathy, matched by age and disease duration and to correlate them with levels of CXCL13 clinical features, laboratory tests and disease activity score. Methods Sixty-four patients with SLE were enrolled, 32 with and 32 without Jaccoud's arthropathy. Each patient underwent physical examination, laboratory tests (including CXCL13 by ELISA) and bilateral US...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29327128/isolated-avulsion-fracture-of-the-first-metatarsal-base-at-the-peroneus-longus-tendon-attachment-a-case-report
#9
Maxwell W Weinberg, Nicola Krähenbühl, Nathan P Davidson, Christopher J Hanrahan, Alexej Barg
Avulsion fractures of the first metatarsal (MT1) base at the peroneus longus (PL) tendon attachment are rare and may be undiagnosed during an emergency visit. If the injury is not treated properly, chronic pain or persistent impairment for inversion and plantar-flexion of the first ray may occur. This case report presents a 30-year-old woman who presented 10 weeks post trauma to a foot and ankle surgeon due to a swollen right midfoot with diffuse tenderness over the medial Lisfranc joint. Further evaluation showed an isolated avulsion fracture of the first metatarsal, which was undiagnosed during the emergent visit following the accident...
January 11, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29327104/long-term-efficacy-of-spa-therapy-in-patients-with-rheumatoid-arthritis
#10
Mine Karagülle, Sinan Kardeş, Müfit Zeki Karagülle
Our previous crossover randomized trial suggested that spa therapy added to usual pharmacotherapy provides benefits that lasted 6 months over pharmacotherapy alone in rheumatoid arthritis patients. We now extend, and report the long-term results of that study. In the crossover trial, patients were randomized to spa therapy first group or control first group (first assignment, period 1, 6 months); after this period and washout phase (9 months), they crossed over to the other arm (second assignment, period 2, 6 months)...
January 11, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29313272/tenascin-c-a-biomarker-of-disease-activity-in-early-ankylosing-spondylitis
#11
Latika Gupta, Shruti Bhattacharya, Amita Aggarwal
Monocytes of patients with ankylosing spondylitis (AS) over-express toll-like receptor (TLR) 4. Tenascin-C (TNC) is an endogenous TLR4 ligand. Thus, we studied the serum and synovial fluid levels of TNC in AS. TNC was measured in serum of 36 AS patients (ASAS 2010 criteria) and 39 healthy controls by ELISA. Twenty-two patients were followed up after 3 months of standard treatment. Five paired serum-synovial fluid samples were also analyzed. Disease activity was assessed by BASDAI, ASDAS, swollen joint count, ESR, and CRP...
January 8, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29302905/the-efficacy-of-probiotic-supplementation-in-rheumatoid-arthritis-a-meta-analysis-of-randomized-controlled-trials
#12
Seyed Mohammad Aqaeinezhad Rudbane, Samane Rahmdel, Seyedeh Maryam Abdollahzadeh, Morteza Zare, Azam Bazrafshan, Seyed Mohammad Mazloomi
Probiotics are considered as -immunomodulatory agents; their efficacy as an adjunct therapy option for rheumatoid arthritis (RA), however, remains controversial. The main aim of the present meta-analysis, therefore, was to compare available data from the published randomized, controlled trials (RCTs) recruiting adults with RA which compared probiotics with placebo. The English literature search was performed using Ovid version of Medline, EmBase, Web of Science, and the Central Cochrane library through October 2016 and supplemented by hand searching reference lists...
January 4, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29302829/effectiveness-and-safety-of-ustekinumab-in-na%C3%A3-ve-or-tnf-inhibitors-failure-psoriatic-arthritis-patients-a-24-month-prospective-multicentric-study
#13
Maria Sole Chimenti, Augusta Ortolan, Mariagrazia Lorenzin, Paola Triggianese, Marina Talamonti, Luisa Costa, Francesco Caso, Marta Favero, Miriam Teoli, Marco Galluzzo, Raffaele Scarpa, Leonardo Punzi, Roberto Perricone, Roberta Ramonda
The current prospective observational study aimed to evaluate the long-term (24 months), real-life effectiveness of ustekinumab in psoriatic arthritis (PsA). Consecutive patients with moderate-severe PsA and active psoriasis who begun ustekinumab treatment were evaluated prospectively (January 2015-March 2017). Clinimetric scores and biochemical values were assessed at baseline (T0), at 6 (T6), 12 (T12), and 24 (T24) months. Friedman test and generalized linear models were used to compare variables over time...
January 4, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29301783/2017-eular-recommendations-for-a-core-data-set-to-support-observational-research-and-clinical-care-in-rheumatoid-arthritis
#14
Helga Radner, Katerina Chatzidionysiou, Elena Nikiphorou, Laure Gossec, Kimme L Hyrich, Condruta Zabalan, Yvonne van Eijk-Hustings, Paula R Williamson, Andra Balanescu, Gerd R Burmester, Loreto Carmona, Maxime Dougados, Axel Finckh, Glenn Haugeberg, Merete Lund Hetland, Susan Oliver, Duncan Porter, Karim Raza, Patrick Ryan, Maria Jose Santos, Annette van der Helm-van Mil, Piet van Riel, Gabrielle von Krause, Jakub Zavada, William G Dixon, Johan Askling
Personalised medicine, new discoveries and studies on rare exposures or outcomes require large samples that are increasingly difficult for any single investigator to obtain. Collaborative work is limited by heterogeneities, both what is being collected and how it is defined. To develop a core set for data collection in rheumatoid arthritis (RA) research which (1) allows harmonisation of data collection in future observational studies, (2) acts as a common data model against which existing databases can be mapped and (3) serves as a template for standardised data collection in routine clinical practice to support generation of research-quality data...
January 4, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29297100/effect-of-daily-low-dose-prednisone-divided-or-single-daily-dose-in-the-treatment-of-african-americans-with-early-rheumatoid-arthritis
#15
Doyt L Conn, Athan Tiliakos, Gaobin Bao, Shuling Li, Kirk A Easley
Determine the effect of daily low divided or single daily dose of prednisone on the longitudinal change in the number of tender and swollen joints and HAQ scores in African Americans (AA) with early rheumatoid arthritis (RA) from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis (CLEAR) 1 Registry. In a prospective, multicenter observational cohort study, AA with early RA were enrolled and followed longitudinally for up to 5 years. 345 were enrolled. The mean age at enrollment was 51 years and 82% were women...
January 3, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29278951/calprotectin-s100a8-a9-should-preferably-be-measured-in-edta-plasma-results-from-a-longitudinal-study-of-patients-with-rheumatoid-arthritis
#16
Hilde Haugedal Nordal, Magne K Fagerhol, Anne-Kristine Halse, Hilde Berner Hammer
Calprotectin (S100A8/A9), a protein expressed in neutrophils and monocytes/macrophages in circulation and inflamed tissue, is associated with measures of disease activity in rheumatoid arthritis (RA) patients both when measured in ethylenediaminetetraacetic acid (EDTA)-plasma and in serum. We wanted to explore if EDTA-plasma or serum should be preferred for calprotectin as a marker of disease activity. Calprotectin was analysed in EDTA-plasma and serum by enzyme-linked immunosorbent assay (ELISA) at baseline in 141 RA patients, starting biologic disease-modifying anti-rheumatic drugs (bDMARDs), and after three months...
December 27, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29278339/determinants-of-patient-s-global-assessment-of-disease-activity-and-physician-s-global-assessment-of-disease-activity-in-patients-with-rheumatoid-arthritis-a-post-hoc-analysis-of-overall-and-japanese-results-from-phase-3-clinical-trials
#17
Yuko Kaneko, Tsutomu Takeuchi, Zhihong Cai, Masayo Sato, Kenta Awakura, Carol Gaich, Baojin Zhu, Jiaying Guo, Yoshiya Tanaka
OBJECTIVES: To assess the determinants of Patient's Global Assessment of Disease Activity (PtGA) and Physician's Global Assessment of Disease Activity (PhGA) in overall and Japanese patients with rheumatoid arthritis (RA) from two large randomized controlled trials. METHODS: Post hoc analysis of overall and Japanese RA patients who had previous inadequate responses to methotrexate or who had no/minimal previous disease-modifying antirheumatic drug treatment. We examined correlations between PtGA/PhGA and tender joint count in 28 joints (TJC28), swollen joint count in 28 joints (SJC28), inflammatory markers, pain visual analog scale (VAS), and other patient-reported outcomes at baseline, Week 12, and Week 24...
December 26, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29276053/inter-observer-agreement-of-standard-joint-count-examination-and-disease-global-assessment-in-a-cohort-of-egyptian-rheumatoid-arthritis-patients
#18
Khaled El-Hadidi, Sherif M Gamal, Sahar Saad
OBJECTIVES: To assess the inter-observer agreement of standard joint count between experienced Rheumatology professor (Prof) and young Rheumatology fellow (candidate), and to compare disease global assessment between professor, young candidate and patients. METHODS: This study included one hundred rheumatoid arthritis patients. For all patients independent clinical evaluation was done by two rheumatologists (professor and candidate) for detection of tenderness in 28 joints and swelling in 26 joints...
December 21, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29228429/peripheral-blood-cd8-t-cell-profiles-in-patients-with-psoriatic-arthritis-a-cross-sectional-case-control-study
#19
E Colombo, G Galleri, G L Erre, C Piras, G Biondi, L Taras, A Zinellu, A A Mangoni, R Manetti, M Montesu, G Passiu
OBJECTIVE: While CD4+ T-cells are traditionally regarded as the main pathogenic T-cell subpopulation in psoriatic arthritis (PsA), the role of circulating CD8+ T-cells remains poorly characterized. We evaluated the differential representation of CD8+ T-cell subpopulations in peripheral blood (PB) of PsA patients. PATIENTS AND METHODS: CD8+IL-17+, CD8+IFNγ+ and CD8+IL-17-IL-22+ T-cells were evaluated by flow-cytometry in 25 consecutive PsA patients, 7 rheumatoid arthritis (RA) patients, 16 patients with psoriasis, and 26 healthy controls (HC)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29187287/association-between-leptin-and-disease-activity-in-patients-with-rheumatoid-arthritis
#20
José Antonio de Jesús Batún-Garrido, Marisol Salas-Magaña, Isela Esther Juárez-Rojop, Eúfrates Hernández-Núñez, Francisco Olán
BACKGROUND AND OBJECTIVE: Multiple studies have found a direct relationship between leptin concentrations and disease activity in rheumatoid arthritis. PATIENTS AND METHODS: We studied 77 patients with the diagnosis of rheumatoid arthritis; the leptin determination was through an enzyme immunoassay. Disease activity was assessed by the DAS-28 CRP. A multivariate logistic regression model was used to determine the association between significant variables and leptin concentrations...
November 26, 2017: Medicina Clínica
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