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https://www.readbyqxmd.com/read/28330716/the-value-of-power-doppler-ultrasound-in-patients-with-rheumatoid-arthritis-in-clinical-remission-reclassifying-disease-activity
#1
Facundo Vergara, Santiago Ruta, Javier Rosa, Josefina Marín, Ricardo García-Mónaco, Enrique R Soriano
OBJECTIVES: The aim of the present study was to describe the ultrasound (US) findings in patients with rheumatoid arthritis (RA) in clinical remission, and to evaluate the ability of power Doppler (PD) US to reclassify disease activity in these patients. MATERIAL AND METHODS: We included consecutive patients with RA according to 2010 American College of Rheumatology/European League Against Rheumatism criteria, who were in clinical remission by the Disease Activity Score (DAS28<2...
March 18, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28325148/the-potent-inhibitory-effect-of-%C3%AE-d-mannuronic-acid-m2000-as-a-novel-nsaid-with-immunosuppressive-property-on-anti-cyclic-citrullinated-peptide-antibodies-rheumatoid-factor-and-anti-dsdna-antibodies-in-patients-with-rheumatoid-arthritis
#2
Hossein Ahmadi, Ahmad Reza Jamshidi, Mahdi Mahmoudi, Salvatore Cuzzocrea, Mohammad Javad Fattahi, Anis Barati, Bernd H A Rehm, Hidenori Matsou, Abbas Mirshafiey
OBJECTIVE: To investigate the inhibitory effect of β-D-mannuronic acid (M2000) on anti-cyclic citrullinated peptide antibodies (anti-CCP), rheumatoid factor (RF), anti-double strand DNA (anti-dsDNA) and acute phase reactants in rheumatoid arthritis (RA) patients. METHODS: The study included 40 patients with RA who had an inadequate response to conventional therapy (identifier: IRCT2014011213739N2). The patients were permitted to continue the conventional therapy excluding NSAIDs...
March 21, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28302406/docosahexaenoic-acid-in-the-treatment-of-rheumatoid-arthritis-a%C3%A2-double-blind-placebo-controlled-randomized-cross-over-study-with-microalgae-vs-sunflower-oil
#3
C Dawczynski, M Dittrich, T Neumann, K Goetze, A Welzel, P Oelzner, S Völker, A M Schaible, F Troisi, L Thomas, S Pace, A Koeberle, O Werz, P Schlattmann, S Lorkowski, G Jahreis
The potential of fish or fish oil as supplier for eicosapentaenoic acid (EPA, C20:5n3) and docosahexaenoic acid (DHA, C22:6n3) for reducing cardiovascular risk factors and supporting therapy of chronic inflammatory diseases, has been investigated intensively, but our knowledge about the physiological effects of the individual compounds EPA and DHA are limited. STUDY DESIGN: In this double-blind pilot study, thirty-eight patients with defined RA were allocated to consume foods enriched with microalgae oil from Schizochytrium sp...
March 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28298560/reliability-and-validity-of-the-tender-and-swollen-joint-counts-and-the-modified-rodnan-skin-score-in-early-diffuse-cutaneous-systemic-sclerosis-analysis-from-the-prospective-registry-of-early-systemic-sclerosis-cohort
#4
Jessica K Gordon, Gandikota Girish, Veronica J Berrocal, Meng Zhang, Christopher Hatzis, Shervin Assassi, Elana J Bernstein, Robyn T Domsic, Faye N Hant, Monique Hinchcliff, Elena Schiopu, Virginia D Steen, Tracy M Frech, Dinesh Khanna
OBJECTIVE: To determine the inter/intraobserver reliability of the tender and swollen joint counts (TJC, SJC) and the modified Rodnan Skin Score (mRSS) in diffuse cutaneous systemic sclerosis (dcSSc) and to assess content validity of the TJC/SJC. METHODS: Ten rheumatologists completed the SJC, TJC, and mRSS on 7 patients. Musculoskeletal ultrasound (MSUS) was performed. RESULTS: Interobserver and intraobserver reliability for the TJC was 0...
March 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28294565/ankle-pathologies-in-patients-with-inflammatory-rheumatic-diseases-a-clinical-and-ultrasonographic-study
#5
Halil Harman, İbrahim Tekeoğlu
AIM: We determined ankle pathologies in patients with different types of inflammatory rheumatic diseases using high-resolution ultrasonographic (US) images, and compared the findings among the different patient groups. METHODS: The study included 142 randomly selected inflammatory rheumatic disease patients with clinically swollen or painful ankle joints; 69 patients had rheumatoid arthritis (RA), 58 had spondyloarthropathies (SpA) and 15 had gout. Ankle assessment on US included all of the important anatomical structures...
March 12, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28293448/serum-calreticulin-as-a-novel-biomarker-of-juvenile-idiopathic-arthritis-disease-activity
#6
Nashwa Ismail Hashaad, Rasha Mohamed Fawzy, Abeer Ahmed Abo Elazem, Mohamed Ibrahim Youssef
OBJECTIVE: This study aimed to investigate the relations between calreticulin (CRT) serum level and both disease activity and severity parameters in juvenile idiopathic arthritis (JIA). MATERIAL AND METHODS: In this study, 60 children with JIA and 50 age-and-sex-matched healthy subjects were enrolled. The assessment of the disease activity was done using juvenile arthritis disease activity score 27 (JADAS-27). The assessment of disease severity was done via gray-scale ultrasonography (US) and power Doppler US (PDUS)...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28282363/the-relationship-between-mental-health-disease-severity-and-genetic-risk-for-depression-in-early-rheumatoid-arthritis
#7
Jack Euesden, Faith Matcham, Matthew Hotopf, Sophia Steer, Andrew P Cope, Cathryn M Lewis, Ian C Scott
OBJECTIVE: Reduced mental health is prevalent in rheumatoid arthritis (RA). Although longitudinal studies are limited, there is evidence that depression associates with worse disease outcomes. We evaluated reciprocal relationships between mental health, RA severity and genetic risks for depression over 2-years in a well-characterised cohort of RA patients. METHODS: We evaluated 520 early RA patients previously enrolled to two clinical trials. Mental health was measured using the SF-36 mental health (MH) domain and mental component summary scores (MCS)...
March 9, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28273969/a-study-on-association-between-common-haematological-parameters-and-disease-activity-in-rheumatoid-arthritis
#8
Manas Talukdar, Gopinath Barui, Anjan Adhikari, Rupam Karmakar, Udas Chandra Ghosh, Tushar Kanti Das
INTRODUCTION: Rheumatoid Arthritis (RA) is a chronic systemic inflammatory disease where assessment of disease activity is essential for management of patient. Currently, many composite scoring systems are used for evaluation of disease activity but they are mainly clinical-based. As several haematological parameters are altered due to systemic inflammatory process in RA, this study was intended to evaluate role of common haematological parameters to assess disease activity in RA. AIM: To find out the association of disease activity of Rheumatoid Arthritis (RA) with platelet count, Mean Platelet Volume (MPV) and Haemoglobin (Hb) level so that these cost-effective haematological parameters can be used as additional factors to assess disease activity...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28271947/health-assessment-questionnaire-disability-index-haq-di-score-at-the-start-of-biological-disease-modifying-antirheumatic-drug-bdmard-therapy-is-associated-with-radiographic-progression-of-large-joint-damage-in-patients-with-rheumatoid-arthritis
#9
Arata Nakajima, Yasuchika Aoki, Keiichiro Terayama, Masato Sonobe, Hiroshi Takahashi, Masahiko Saito, Koichi Nakagawa
OBJECTIVES: Radiographic progression of damage (RPD) to large joints in patients with rheumatoid arthritis (RA) has not been fully studied. We previously demonstrated that Larsen grade of the large joints was associated with RPD of large joints in patients treated with biological disease-modifying anti-rheumatic drugs (bDMARDs); however, no factors associated with background characteristics of patients were identified. METHODS: A total of 400 large joints in the upper and lower extremities, including the shoulder, elbow, knee, and ankle, of 88 patients with RA treated with bDMARDs for 1-3 years were investigated...
March 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28271234/impact-of-prior-biologic-use-on-persistence-of-treatment-in-patients-with-psoriatic-arthritis-enrolled-in-the-us-corrona-registry
#10
Leslie R Harrold, Bradley S Stolshek, Sabrina Rebello, David H Collier, Alex Mutebi, Sally W Wade, Wendi Malley, Jeffrey D Greenberg, Carol J Etzel
Psoriatic arthritis (PsA) is a chronic condition characterized by a diverse set of symptoms, from swollen joints to nail disease to skin disease. A variety of treatment options are available, including tumor necrosis factor inhibitors (TNFis). Little is known about treatment persistence in patients with PsA who initiate TNFi therapy, with and without prior biologic use. This study assessed persistence in these subgroups of patients with PsA and identified factors associated with persistence. This retrospective study utilized data from the Corrona registry of patients with PsA-with or without prior biologic experience-who initiated TNFi therapy between October 1, 2002, and March 21, 2013...
March 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28259162/joint-specific-assessment-of-swelling-and-power-doppler-in-obese-rheumatoid-arthritis-patients
#11
Erin M Bauer, Ami Ben-Artzi, Erin L Duffy, David A Elashoff, Sitaram S Vangala, John Fitzgerald, Veena K Ranganath
BACKGROUND: Clinical swollen joint examination of the obese rheumatoid arthritis (RA) patient can be difficult. Musculoskeletal Ultrasound (MSUS) has higher sensitivity than physical examination for swollen joints (SJ). The purpose of this study was to determine the joint-specific association between power Doppler (PDUS) and clinical SJ in RA across body mass index (BMI) categories. METHODS: Cross-sectional clinical and laboratory data were collected on 43 RA patients...
March 4, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28238086/misalignment-between-physicians-and-patient-satisfaction-with-psoriatic-arthritis-disease-control
#12
Daniel E Furst, Melody Tran, Emma Sullivan, James Pike, James Piercy, Vivian Herrera, Jacqueline B Palmer
The main objective of the present study is to evaluate the misalignment between psoriatic arthritis (PsA) patient- and physician-reported satisfaction with PsA control. Data came from the Adelphi Rheumatology Disease Specific Programme, a retrospective, cross-sectional survey of US-based rheumatologists and patients. Physicians provided satisfaction and clinical characteristics on tender joint count, swollen joint count, and percent body surface area (BSA) affected by psoriasis. Patients provided data on satisfaction, the Work Productivity Activity Impairment and Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires...
February 25, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28223263/apps-for-people-with-rheumatoid-arthritis-to-monitor-their-disease-activity-a-review-of-apps-for-best-practice-and-quality
#13
Rebecca Grainger, Hermaleigh Townsley, Bonnie White, Tobias Langlotz, William J Taylor
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis requiring long-term treatment with regular monitoring by a rheumatologist to achieve good health outcomes. Since people with RA may wish to monitor their own disease activity with a smartphone app, it is important to understand the functions and quality of apps for this purpose. OBJECTIVE: The aim of our study was to assess the features and quality of apps to assist people to monitor their RA disease activity by (1) summarizing the available apps, particularly the instruments used for measurement of RA disease activity; (2) comparing the app features with American College of Rheumatology and European League against Rheumatism (ACR and EULAR) guidelines for monitoring of RA disease activity; and (3) rating app quality with the Mobile App Rating Scale (MARS)...
February 21, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28215362/efficacy-and-safety-of-sirukumab-in-patients-with-active-rheumatoid-arthritis-refractory-to-anti-tnf-therapy-sirround-t-a-randomised-double-blind-placebo-controlled-parallel-group-multinational-phase-3-study
#14
Daniel Aletaha, Clifton O Bingham, Yoshiya Tanaka, Prasheen Agarwal, Regina Kurrasch, Paul P Tak, Sharon Popik
BACKGROUND: Sirukumab, a human monoclonal antibody that selectively binds to the interleukin-6 cytokine with high affinity, is under development for the treatment of rheumatoid arthritis and other diseases. We aimed to assess the efficacy and safety of sirukumab for rheumatoid arthritis in a phase 3 study (SIRROUND-T). METHODS: We did a randomised, double-blind, placebo-controlled, parallel-group, multicentre study at 183 hospitals and private rheumatology clinics in 20 countries (Argentina, Australia, Austria, Belgium, Canada, France, Germany, Italy, Japan, Lithuania, Mexico, Netherlands, Poland, Portugal, Russia, South Korea, Spain, Taiwan, UK, and USA)...
February 15, 2017: Lancet
https://www.readbyqxmd.com/read/28213566/a-randomised-phase-iib-study-of-mavrilimumab-a-novel-gm-csf-receptor-alpha-monoclonal-antibody-in-the-treatment-of-rheumatoid-arthritis
#15
Gerd R Burmester, Iain B McInnes, Joel Kremer, Pedro Miranda, Mariusz Korkosz, Jiri Vencovsky, Andrea Rubbert-Roth, Eduardo Mysler, Matthew A Sleeman, Alex Godwood, Dominic Sinibaldi, Xiang Guo, Wendy I White, Bing Wang, Chi-Yuan Wu, Patricia C Ryan, David Close, Michael E Weinblatt
OBJECTIVES: Despite the therapeutic value of current rheumatoid arthritis (RA) treatments, agents with alternative modes of action are required. Mavrilimumab, a fully human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, was evaluated in patients with moderate-to-severe RA. METHODS: In a phase IIb study (NCT01706926), patients with inadequate response to ≥1 synthetic disease-modifying antirheumatic drug(s), Disease Activity Score 28 (DAS28)-C reactive protein (CRP)/erythrocyte sedimentation rate ≥3...
February 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28185415/relationship-between-clinical-evaluation-and-ultrasound-assessment-of-rheumatoid-arthritis-patients-using-a-12-joint-score
#16
Marcos Cerqueira, Filipa Teixeira, Joana Sousa Neves, Daniela Peixoto, Maria Carmo Afonso, José A Costa
AIM: To identify if the use of a systematic ultrasound (US) evaluation has relevance in the determination of disease activity in rheumatoid arthritis patients on biological disease-modifying anti-rheumatic drug treatment. METHODS: A 12 joint US assessment was performed on the same day of the routine clinical examination. Both Grey-scale (GS) and Power Doppler (PD) were graded semi-quantitatively (0-3 scale). RESULTS: Forty-one patients were included...
February 9, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28164055/proximal-tibial-epiphysis-injury-flexion-type-salter-harris-type-1
#17
Pratik Israni, Mangesh Panat
INTRODUCTION: Fractures of the proximal tibial epiphysis rare. It has been estimated that fractures of the upper tibial epiphysis account for 0.5-3.1% of all epiphyseal injuries. Who had no neurovascular deficit, with fixed extension deformity at the left knee was treated early with closed reduction techniques. CASE REPORT: We present a case of a 16-year-old boy who while playing cricket on the road was hit by a car. The patient presented in emergency room with extremely swollen knee and soft tissue swelling (hemarthrosis), he was unable to lift his leg actively due to severe pain because of hamstrings spasm, and he had no wound over his left knee and had no other associated injuries...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28148302/blood-chemokine-profile-in-untreated-early-rheumatoid-arthritis-cxcl10-as-a-disease-activity-marker
#18
Jayesh M Pandya, Anna-Carin Lundell, Kerstin Andersson, Inger Nordström, Elke Theander, Anna Rudin
BACKGROUND: We have recently analyzed the profile of T-cell subtypes based on chemokine receptor expression in blood from untreated early rheumatoid arthritis (ueRA) patients compared to healthy controls (HC). Here, we compared the levels of the respective chemokines in blood plasma of ueRA patients with those of HC. We also studied the association of chemokine levels with the proportions of circulating T-cell subsets and the clinical disease activity. METHODS: Peripheral blood was obtained from 43 patients with ueRA satisfying the ACR 2010 criteria and who had not received any disease-modifying anti-rheumatic drugs (DMARD) or prednisolone, and from 14 sex- and age-matched HC...
February 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28117013/gray-scale-and-power-doppler-ultrasonographic-findings-in-the-assessment-of-disease-activity-and-their-correlation-with-disease-activity-parameters-in-rheumatoid-arthritis
#19
Sandeep Jindal, Reshma Kaushik, Shailendra Raghuvanshi, Rajeev Mohan Kaushik, Rajesh Kakkar
OBJECTIVES: To study the utility of gray scale and power Doppler ultrasonography in assessing the disease activity and correlation of ultrasonographic findings with disease activity parameters in rheumatoid arthritis (RA). MATERIALS AND METHODS: This cross-sectional study was conducted on 100 RA patients diagnosed as per 2010 classification criteria. Rheumatoid factor (RF), serum anti-cyclic citrullinated peptide antibodies (ACPA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), disease activity score with 28-joint counts and ESR (DAS28-ESR), visual analogue scale (VAS) for global disease activity and gray scale ultrasonography (GSUS) and power Doppler ultrsonography (PDUS) scores in hands and wrists were determined...
January 19, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28100982/bilateral-lower-extremity-edema-caused-by-iliopsoas-bursal-distention-after-hip-arthroplasty
#20
Sameer K Avasarala, Syed T Ahsan
Lower-extremity edema is encountered by internists, nephrologists, vascular specialists, and many others. We report a case of an elderly woman who presented with a painful, swollen left leg. Without a clear diagnosis, she had been taking diuretics for the past 8 years for swelling in both legs. After extensive investigation, we found that her lower-extremity edema was due to bilateral iliopsoas bursal distention secondary to degeneration of her hip prostheses. Chronic breakdown of the polyethylene component of the hip prostheses had led to a communication between the artificial joints and the iliopsoas bursae...
December 2016: Texas Heart Institute Journal
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