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Diabetes and cognition

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https://www.readbyqxmd.com/read/28640243/in-depth-investigations-of-adolescents-and-adults-with-holoprosencephaly-identify-unique-characteristics
#1
Karin Weiss, Paul Kruszka, Maria J Guillen Sacoto, Yonit A Addissie, Donald W Hadley, Casey K Hadsall, Bethany Stokes, Ping Hu, Erich Roessler, Beth Solomon, Edythe Wiggs, Audrey Thurm, Robert B Hufnagel, Wadih M Zein, Jin S Hahn, Elaine Stashinko, Eric Levey, Debbie Baldwin, Nancy J Clegg, Mauricio R Delgado, Maximilian Muenke
PurposeWith improved medical care, some individuals with holoprosencephaly (HPE) are surviving into adulthood. We investigated the clinical manifestations of adolescents and adults with HPE and explored the underlying molecular causes.MethodsParticipants included 20 subjects 15 years of age and older. Clinical assessments included dysmorphology exams, cognitive testing, swallowing studies, ophthalmic examination, and brain magnetic resonance imaging. Genetic testing included chromosomal microarray, Sanger sequencing for SHH, ZIC2, SIX3, and TGIF, and whole-exome sequencing (WES) of 10 trios...
June 22, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28638916/-different-subtypes-of-estrogen-receptor-%C3%AE-and-related-signal-molecules-in-the-hippocampus-are-associated-with-spatial-cognitive-impairment-of-diabetic-mice
#2
Ming-Rui Zhang, Chao Qu, Jia Sun, Cui Wang, Hong-Yan Li, Ye-Jun Zhang, Bing-Qiang Zhang, Wei Zou
To study the correlation between the spatial cognitive impairment and different subtypes of estrogen receptor α (ERα) of hippocampus in diabetic mice, we used alloxan (intraperitoneal injection) to induce type 1 diabetes in male Kunming mice and compared the spatial cognitive ability of the model mice with that of control mice through Morris water maze test. Meanwhile, using Western blot, we detected the protein expressions of ER-α36, ER-α66, caveolin-1, PKCα, cAMP-response element binding protein 2 (CREB2), and synaptophysin (Syn) in the hippocampus of the mice...
June 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28634451/berberine-ameliorates-diabetes-associated-cognitive-decline-through-modulation-of-aberrant-inflammation-response-and-insulin-signaling-pathway-in-dm-rats
#3
Qingjie Chen, Ran Mo, Ninghua Wu, Xin Zou, Cai Shi, Jing Gong, Jingbin Li, Ke Fang, Dingkun Wang, Deshen Yang, Kaifu Wang, Juan Chen
Background: Memory-impairment was one of the common characteristics in patients with diabetes mellitus. The release of chronic inflammation mediators and insulin resistance in diabetic brain gave rise to the generation of toxic factor Aβ42 which was the marker of Alzheimer's disease. In addition, the impairment of memory in diabetes mellitus was also correlated predominantly with uptake/metabolism of glucose in medial prefrontal cortex (mPFC). Previously, anti-inflammation and hypoglycemic effects of berberine (BBr) have been described in peripheral tissues...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28634202/hemoglobin-a1c-variability-predicts-symptoms-of-depression-in-elderly-individuals-with-type-2-diabetes
#4
Ramit Ravona-Springer, Anthony Heymann, James Schmeidler, Erin Moshier, Elizabeth Guerrero-Berroa, Laili Soleimani, Mary Sano, Derek Leroith, Rachel Preiss, Ruth Tzukran, Jeremy M Silverman, Michal Schnaider Beeri
OBJECTIVE: This study aimed to analyze the relationship of variability in hemoglobin A1c (HbA1c) over years with subsequent depressive symptoms. RESEARCH DESIGN AND METHODS: Subjects (n = 837) were participants of the Israel Diabetes and Cognitive Decline (IDCD) study, which aimed to examine the relationship of characteristics of long-term type 2 diabetes with cognitive decline. All pertain to a diabetes registry established in 1998, which contains an average of 18 HbA1c measurements per subject...
June 20, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28633346/tetramethylpyrazine-reverses-intracerebroventricular-streptozotocin-induced-memory-deficits-by-inhibiting-gsk-3%C3%AE
#5
Fen Lu, Xu Li, Wei Li, Ke Wei, Yong Yao, Qianlin Zhang, Xinliang Liang, Jiewen Zhang
Brain dysfunction, especially cognitive impairment, is one of the main complications in Alzheimer's disease (AD), which threatens the health of 46.8 million people worldwide. At present, the pathogenesis of cognitive dysfunction is only partially understood, and effective therapies for memory loss in AD remain elusive. Tetramethylpyrazine (TMP) is one of the major bioactive compounds purified from Chuanxiong, a Chinese herb used for the treatment of neurovascular and cardiovascular diseases. The neuroprotective properties of TMP are evident in some neurodegenerative diseases, including Parkinson's disease...
June 15, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28633303/cognitive-trajectories-in-prediabetes-and-diabetes-a-population-based-cohort-study
#6
Anna Marseglia, Anna K Dahl Aslan, Laura Fratiglioni, Giola Santoni, Nancy L Pedersen, Weili Xu
Background: Diabetes has been linked to dementia risk; however, the cognitive trajectories in older adults with diabetes remain unclear. We aimed to investigate the effect of prediabetes and diabetes on cognitive trajectories among cognitively intact older adults in a long-term follow-up study. Methods: Within the Swedish Adoption/Twin Study of Aging, 793 cognitively intact older adults aged ≥50 were identified at baseline and followed for up to 23 years. Based on standardized scores from 11 cognitive tests, administered at baseline and up to seven follow-ups, four cognitive domains (verbal abilities, spatial/fluid, memory, perceptual speed) were identified by principal-component analysis...
June 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28632780/metformin-intake-associates-with-better-cognitive-function-in-patients-with-huntington-s-disease
#7
David Hervás, Victoria Fornés-Ferrer, Ana Pilar Gómez-Escribano, María Dolores Sequedo, Carmen Peiró, José María Millán, Rafael P Vázquez-Manrique
Huntington's disease (HD) is an inherited, dominant neurodegenerative disorder caused by an abnormal expansion of CAG triplets in the huntingtin gene (htt). Despite extensive efforts to modify the progression of HD thus far only symptomatic treatment is available. Recent work suggests that treating invertebrate and mice HD models with metformin, a well-known AMPK activator which is used worldwide to treat type 2-diabetes, reduces mutant huntingtin from cells and alleviates many of the phenotypes associated to HD...
2017: PloS One
https://www.readbyqxmd.com/read/28631969/cognitive-functions-among-predominantly-minority-urban-adolescents-with-metabolic-syndrome
#8
Alexander Mangone, Kathy F Yates, Victoria Sweat, Adriana Joseph, Antonio Convit
The rise in the rate of adolescent obesity has led to a concurrent rise in the rate of metabolic syndrome (MetS) among young people. In addition to diabetes and cardiovascular disease, MetS has also been linked to cognitive dysfunction. The goal of this study was to assess whether cognitive differences exist between minority urban adolescents carrying excess weight who meet criteria for MetS as compared to their peers without MetS. Two hundred and ninety-six urban adolescents, predominantly Hispanic and carrying excess weight as defined by a BMI above 25 kg/m(2), were screened for MetS and divided into MetS and no MetS groups...
February 22, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28628790/associated-illness-severity-in-schizophrenia-and-diabetes-mellitus-a-systematic-review
#9
REVIEW
Benjamin I Perry, Dhanya Salimkumar, Daniel Green, Anne Meakin, Andrew Gibson, Deepali Mahajan, Tayyeb Tahir, Swaran P Singh
OBJECTIVE: We aimed to elucidate whether schizophrenia and type II diabetes mellitus may present with associated illness severity, in light of accumulating evidence to suggest both conditions have important shared inflammatory components with many shared inflammatory genetic factors. METHODS: We conducted a systematic review employing PRISMA criteria, searching EMBASE, Ovid MEDLINE, PsychInfo, Web of Science and Google Scholar to February 1st, 2017, for clinical studies assessing schizophrenia severity alongside dysglycaemia...
June 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28628018/autoimmune-limbic-encephalitis-case-reports
#10
K Kobaidze, A Harrison, Y Burklin, V Patidar, M Riccardi
Limbic encephalitis (LE) is an autoimmune or paraneoplastic disease that affects the medial temporal lobes. The patient will usually present with cognitive impairment, psychiatric changes, and seizures. Autoimmune limbic encephalitis (LE) is a challenging diagnosis as it is not always included in the typical paraneoplastic/autoimmune panels. Anti-GAD antibodies are associated with various disease including type I diabetes mellitus, various autoimmune processes, some neoplastic and infectious diseases. Thus, it is not as specific as some of the antibodies causing LE...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28626906/behavioural-implications-of-traditional-treatment-and-closed-loop-automated-insulin-delivery-systems-in-type-1-diabetes-applying-a-cognitive-restraint-theory-framework
#11
REVIEW
A R Kahkoska, E J Mayer-Davis, K K Hood, D M Maahs, K S Burger
As the prevalence of obesity in Type 1 diabetes rises, the effects of emerging therapy options should be considered in the context of both weight and glycaemic control outcomes. Artificial pancreas device systems will 'close the loop' between blood glucose monitoring and automated insulin delivery and may transform day-to-day dietary management for people with Type 1 diabetes in multiple ways. In the present review, we draw directly from cognitive restraint theory to consider unintended impacts that closed-loop systems may have on ingestive behaviour and food intake...
June 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28626807/the-association-between-western-and-prudent-dietary-patterns-and-fasting-blood-glucose-levels-in-type-2-diabetes-and-normal-glucose-metabolism-in-older-australian-adults
#12
Erin I Walsh, Felice N Jacka, Peter Butterworth, Kaarin J Anstey, Nicolas Cherbuin
High blood glucose and type 2 diabetes are associated with a range of adverse health and cognitive outcomes. One factor that contributes to high blood glucose and type 2 diabetes is dietary intake. This study investigated the relationship between dietary patterns, fasting blood glucose and diabetes status in a sample of 209 participants aged 60-65. Blood plasma glucose was measured from venous blood samples. Individual Prudent and Western dietary patterns were estimated from a self-completed food frequency questionnaire...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28625907/long-standing-isolated-autoimmune-hypothalamitis-diagnosed-with-endoscopic-transventricular-biopsy-a-case-report
#13
Lorenzo Bertulli, Giulio Andrea Bertani, Umberto Gianelli, Giovanna Mantovani, Paolo Maria Rampini, Marco Locatelli
BACKGROUND: Autoimmune hypothalamitis, which is among the causes of acquired central diabetes insipidus, has been described very rarely in the literature. This condition is probably provoked by the production of anti-vasopressin secreting cells antibodies and anti-hypothalamus antibodies, and is often associated with pituitary or polyendocrine autoimmunity. Correct diagnosis and immediate treatment are essential in order to avoid the progression of the pathological process. CASE DESCRIPTION: A woman diagnosed with central diabetes insipidus 12 year ago, suffering from panhypopituitarism and mild memory deficit came to our attention...
June 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28625014/comparison-in-executive-function-in-chinese-preterm-and-full-term-infants-at-eight-months
#14
Yao Feng, Hong Zhou, Yan Zhang, Anthony Perkins, Yan Wang, Jing Sun
Executive function (EF) is increasingly recognized as being responsible for adverse developmental outcomes in preterm-born infants. Several perinatal factors may lead to poor EF development in infancy, and the deficits in EF can be identified in infants as young as eight months. A prospective cohort study was designed to study the EF in Chinese preterm infants and examine the relationship between EF in preterm infants and maternal factors during perinatal period. A total of 88 preterm infants and 88 full-term infants were followed from birth to eight months (corrected age)...
June 17, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28624149/brain-function-and-structure-and-risk-for-incident-diabetes-the-atherosclerosis-risk-in-communities-study
#15
Michael P Bancks, Alvaro Alonso, Rebecca F Gottesman, Thomas H Mosley, Elizabeth Selvin, James S Pankow
INTRODUCTION: Diabetes is prospectively associated with cognitive decline. Whether lower cognitive function and worse brain structure are prospectively associated with incident diabetes is unclear. METHODS: We analyzed data for 10,133 individuals with cognitive function testing (1990-1992) and 1212 individuals with brain magnetic resonance imaging (1993-1994) from the Atherosclerosis Risk in Communities cohort. We estimated hazard ratios for incident diabetes through 2014 after adjustment for traditional diabetes risk factors and cohort attrition...
June 14, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28622335/psychotic-symptoms-in-older-people-without-dementia-from-a-brazilian-community-based-sample-a-seven-years-follow-up
#16
Walter Barbalho Soares, Eriton Barros Dos Santos, Cássio Machado de Campos Bottino, Helio Elkis
BACKGROUND: Studies of the incidence of psychotic symptoms in elderly people at risk of dementia are scarce. This is a seven year follow up study aiming to determine the incidence of psychotic symptoms and their correlation with other clinical aspects, in particular the rate of development of cognitive impairment. METHODS: Cohort study of a community-based sample of elderly subjects. At study entry in 2004, the sample was composed of 1,125 individuals aged 60 years and older...
2017: PloS One
https://www.readbyqxmd.com/read/28621148/association-between-cognitive-vulnerability-to-depression%C3%A2-%C3%A2-dysfunctional-attitudes-and-glycaemic-control-among-in-patients-with-type-2-diabetes-in-a-hospital-in-beijing-a-multivariate-regression-analysis
#17
Yue Ma, Xun Li, Dandan Zhao, Rui Wu, Hongfeng Sun, Shibo Chen, Linyun Wang, Xue Fang, Jin Huang, Xia Li, Ying Zhang, Guangjian Jiang, Dongwei Zhang, Yanyun Pan, Tian An, Yue Shi, Jiacheng Zuo, Na Yu, Sihua Gao
This cross-sectional study aimed to investigate the relationship between glycosylated haemoglobin (HbA1c) and cognitive vulnerability to depression (dysfunctional attitudes) in patients with type 2 diabetes mellitus. A total of 245 valid records from June 2016 to December 2016 were collected from a hospital in Beijing. Participants were asked to complete four questionnaires (Dysfunctional Attitudes Scale, Automatic Thoughts Questionnaire, Zung Self-rating Depression Scale, and World Health Organization Quality of Life Instrument-Short Form) to assess mental health and quality of life...
June 16, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28619307/pilot-randomized-controlled-trial-of-a-mindfulness-based-group-intervention-in-adolescent-girls-at-risk-for-type-2-diabetes-with-depressive-symptoms
#18
Lauren B Shomaker, Stephanie Bruggink, Bernadette Pivarunas, Amanda Skoranski, Jillian Foss, Ella Chaffin, Stephanie Dalager, Shelly Annameier, Jordan Quaglia, Kirk Warren Brown, Patricia Broderick, Christopher Bell
OBJECTIVE: (1) Evaluate feasibility and acceptability of a mindfulness-based group in adolescent girls at-risk for type 2 diabetes (T2D) with depressive symptoms, and (2) compare efficacy of a mindfulness-based versus cognitive-behavioral group for decreasing depressive symptoms and improving insulin resistance. DESIGN AND SETTING: Parallel-group, randomized controlled pilot trial conducted at a university. PARTICIPANTS: Thirty-three girls 12-17y with overweight/obesity, family history of diabetes, and elevated depressive symptoms were randomized to a six-week mindfulness-based (n=17) or cognitive-behavioral program (n=16)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28617932/effect-of-the-treatment-of-type-2-diabetes-mellitus-on-the-development-of-cognitive-impairment-and-dementia
#19
REVIEW
Almudena Areosa Sastre, Robin Wm Vernooij, Magali González-Colaço Harmand, Gabriel Martínez
BACKGROUND: Prevention of cognitive impairment and dementia is an important public health goal. Epidemiological evidence shows a relationship between cognitive impairment and Type 2 diabetes mellitus. The risk of dementia increases with duration of disease. This updated systematic review investigated the effect on cognitive function of the type of treatment and level of metabolic control in people with Type 2 diabetes. OBJECTIVES: To assess the effects of different strategies for managing Type 2 diabetes mellitus on cognitive function and the incidence of dementia...
June 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28616995/the-hippocampus-and-the-regulation-of-human-food-intake
#20
Richard J Stevenson, Heather M Francis
Human and animal data suggest that the hippocampus plays certain roles in regulating food intake. However, its actual role may be far broader than currently envisaged, a claim suggested by the centrality of the hippocampus to so many aspects of human/animal cognition. Understanding these ingestion-related functions is especially significant. This is because some degree of hippocampal impairment may be quite common, resulting for example from a Western-style diet, insomnia, diabetes, and depression-among many other causes...
June 15, 2017: Psychological Bulletin
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