Hanif Esmail, Anna K Coussens, Friedrich Thienemann, Bianca Sossen, Sandra L Mukasa, James Warwick, Rene T Goliath, Nashreen Omar Davies, Emily Douglass, Amanda Jackson, Francisco Lakay, Elizabeth Streicher, Jacob E Munro, Marilou H Barrios, Torben Heinsohn, Liana Macpherson, Dylan Sheerin, Saalikha Aziz, Keboile Serole, Remy Daroowala, Arshad Taliep, Petri Ahlers, Stephanus T Malherbe, Rory Bowden, Robin Warren, Gerhard Walzl, Laura E Via, Melanie Bahlo, Karen R Jacobson, C Robert Horsburgh, Padmini Salgame, David Alland, Clifton Earl Barry, JoAnne L Flynn, Jerrold J Ellner, Robert J Wilkinson
BACKGROUND: The evolution of tuberculosis (TB) disease during the clinical latency period remains incompletely understood. METHODS: 250 HIV-uninfected, adult household contacts of rifampicin-resistant TB with a negative symptom screen underwent baseline 18 F-Fluorodeoxyglucose positron emission and computed tomography (PET/CT), repeated in 112 after 5-15 months. Following South African and WHO guidelines, participants did not receive preventive therapy. All participants had intensive baseline screening with spontaneous, followed by induced, sputum sampling and were then observed for an average of 4...
July 3, 2023: medRxiv