Joshua D Bromley, Sharie Keanne C Ganchua, Sarah K Nyquist, Pauline Maiello, Michael Chao, H Jacob Borish, Mark Rodgers, Jaime Tomko, Kara Kracinovsky, Douaa Mugahid, Son Nguyen, Dennis Wang, Jacob M Rosenberg, Edwin C Klein, Hannah P Gideon, Roisin Floyd-O'Sullivan, Bonnie Berger, Charles A Scanga, Philana Ling Lin, Sarah M Fortune, Alex K Shalek, JoAnne L Flynn
Immunological priming - either in the context of prior infection or vaccination - elicits protective responses against subsequent Mycobacterium tuberculosis ( Mtb ) infection. However, the changes that occur in the lung cellular milieu post-primary Mtb infection and their contributions to protection upon reinfection remain poorly understood. Here, using clinical and microbiological endpoints in a non-human primate reinfection model, we demonstrate that prior Mtb infection elicits a long-lasting protective response against subsequent Mtb exposure and that the depletion of CD4 + T cells prior to Mtb rechallenge significantly abrogates this protection...
December 21, 2023: bioRxiv