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Tuberculosis pet-ct

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https://www.readbyqxmd.com/read/29670497/comparing-the-differential-diagnostic-values-of-18-f-alfatide-ii-pet-ct-between-tuberculosis-and-lung-cancer-patients
#1
Xiaoqing Du, Yu Zhang, Liping Chen, Baoming Mi, Qingjun You, Yuping Xu, Donghui Pan, Weixing Wan, Min Yang, Chunjing Yu
Purpose: To compare the differential diagnostic values of 18 F-Alfatide II PET/CT between tuberculosis and lung cancer patients and in patients with sarcoidosis and common inflammation. Methods: Nine inflammation patients (4 tuberculosis, 3 sarcoidosis, and 2 common inflammation) and 11 lung cancer patients were included in this study. All patients underwent 18 F-FDG and 18 F-Alfatide II PET/CT within 2 weeks, followed by biopsy and surgery. The maximized standard uptake value (SUVmax) and the mean standard uptake value (SUVmean) were evaluated...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29528048/using-biomarkers-to-predict-tb-treatment-duration-predict-tb-a-prospective-randomized-noninferiority-treatment-shortening-clinical-trial
#2
Ray Y Chen, Laura E Via, Lori E Dodd, Gerhard Walzl, Stephanus T Malherbe, André G Loxton, Rodney Dawson, Robert J Wilkinson, Friedrich Thienemann, Michele Tameris, Mark Hatherill, Andreas H Diacon, Xin Liu, Jin Xing, Xiaowei Jin, Zhenya Ma, Shouguo Pan, Guolong Zhang, Qian Gao, Qi Jiang, Hong Zhu, Lili Liang, Hongfei Duan, Taeksun Song, David Alland, Michael Tartakovsky, Alex Rosenthal, Christopher Whalen, Michael Duvenhage, Ying Cai, Lisa C Goldfeder, Kriti Arora, Bronwyn Smith, Jill Winter, Clifton E Barry Iii
Background : By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months, maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have failed, with 4-month arms consistently having relapse rates of 15-20%. One trial shortened treatment only among those without baseline cavity on chest x-ray and whose month 2 sputum culture converted to negative. The 4-month arm relapse rate decreased to 7% but was still significantly worse than the 6-month arm (1.6%, P<0.01).  We hypothesize that PET/CT characteristics at baseline, PET/CT changes at one month, and markers of residual bacterial load will identify patients with tuberculosis who can be cured with 4 months (16 weeks) of standard treatment...
November 6, 2017: Gates open research
https://www.readbyqxmd.com/read/29503358/-pyothorax-associated-lymphoma-with-the-expression-of-epstein-barr-virus-latent-genes
#3
Hajime Senjo, Akio Mori, Minoru Kanaya, Koh Izumiyama, Kohei Okada, Kimihiro Takeyabu, Hirotoshi Tobioka, Makoto Saito, Masanori Tanaka, Takanori Teshima, Masanobu Morioka
An 84-year-old man, who had received artificial pneumothorax for pulmonary tuberculosis 67 years previously, complained of severe chest pain. Chest CT revealed chronic pyothorax with multiple heterogeneously enhanced cavity lesions in the wall of the right intrathoracic space.18 FDG-PET revealed that the lesions showed an abnormal uptake. CT-guided biopsy was performed and he was diagnosed with pyothorax-associated lymphoma (PAL); the histological diagnosis was diffuse large B cell lymphoma (DLBCL). Furthermore, immunohistochemical staining revealed that the tumor cells were positive for EBNA-2 and LMP-1, suggesting that the latent gene products of Epstein-Barr virus were associated with the development of PAL...
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29452619/monitoring-response-to-therapy
#4
REVIEW
Mike M Sathekge, Alfred O Ankrah, Ismaheel Lawal, Mariza Vorster
Monitoring response to treatment is a key element in the management of infectious diseases, yet controversies still persist on reliable biomarkers for noninvasive response evaluation. Considering the limitations of invasiveness of most diagnostic procedures and the issue of expression heterogeneity of pathology, molecular imaging is better able to assay in vivo biologic processes noninvasively and quantitatively. The usefulness of18 F-FDG-PET/CT in assessing treatment response in infectious diseases is more promising than for conventional imaging...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452616/tuberculosis
#5
REVIEW
Alfred O Ankrah, Andor W J M Glaudemans, Alex Maes, Christophe Van de Wiele, Rudi A J O Dierckx, Mariza Vorster, Mike M Sathekge
Tuberculosis (TB) is currently the world's leading cause of infectious mortality. Imaging plays an important role in the management of this disease. The complex immune response of the human body to Mycobacterium tuberculosis results in a wide array of clinical manifestations, making clinical and radiological diagnosis challenging.18 F-FDG-PET/CT is very sensitive in the early detection of TB in most parts of the body; however, the lack of specificity is a major limitation.18 F-FDG-PET/CT images the whole body and provides a pre-therapeutic metabolic map of the infection, enabling clinicians to accurately assess the burden of disease...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29427823/contribution-of-diagnostic-tests-for-the-etiological-assessment-of-uveitis-data-from-the-ulisse-study-uveitis-clinical-and-medicoeconomic-evaluation-of-a-standardized-strategy-of-the-etiological-diagnosis
#6
REVIEW
Pierre Grumet, Laurent Kodjikian, Audrey de Parisot, Marie-Hélène Errera, Neila Sedira, Emmanuel Heron, Laurent Pérard, Pierre-Loïc Cornut, Christelle Schneider, Sophie Rivière, Priscille Ollé, Grégory Pugnet, Pascal Cathébras, Pierre Manoli, Bahram Bodaghi, David Saadoun, Stéphanie Baillif, Nathalie Tieulie, Marc Andre, Frédéric Chiambaretta, Nicolas Bonin, Philip Bielefeld, Alain Bron, Frédéric Mouriaux, Boris Bienvenu, Stéphanie Vicente, Sylvie Bin, Marc Labetoulle, Christiane Broussolle, Yvan Jamilloux, Evelyne Decullier, Pascal Sève
PURPOSE: ULISSE is the only study that prospectively assessed the efficiency of a standardized strategy, compared to an open strategy for the etiologic diagnosis of uveitis. Our aim was to evaluate the diagnostic yield of the tests prescribed in the ULISSE study to clarify their relevance. METHODS: ULISSE is a non-inferiority, prospective, multicenter and cluster randomized study. The standardized strategy is a two-steps strategy: in the first step, common standard tests were performed, and in the second step, tests were guided by the clinical and anatomic type of uveitis...
February 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29399349/atypical-spleen-tuberculosis-in-a-melanoma-patient-accidentally-detected-during-a-18f-fdg-pet-ct-study-case-report
#7
Paulina Cegla, Arkadiusz Spychala, Andrzej Marszalek, Ewa Wierzchoslawska, Witold Cholewinski
The present study, discussed a rare case of a 50-year-old woman who was treated for malignant melanoma and underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) examination for evaluation of disease. 18F-FDG-PET/CT examination was performed from the top of the head down to the knee using a Gemini TF PET/CT scanner 60 min following intravenous injection of radiotracer with mean activity of 364±75 MBq. Previous performed laboratory test and clinical examination was irrelevant...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29375875/pet-ct-imaging-in-management-of-concomitant-hodgkin-lymphoma-and-tuberculosis-a-problem-solver-tool
#8
Nina Jehanno, Thibaut Cassou-Mounat, Anne Vincent-Salomon, Marie Luporsi, Manel Bedoui, Frédérique Kuhnowski
Infectious lymph nodes mimicking lymphoma is challenging for accurate staging. Although 18F-FDG is a nonspecific tracer accumulating not only in tumor cells but also in inflammatory tissues, the metabolic features and uptake kinetics give valuable information: 18F-FDG PET/CT appears as a useful problem solver tool in ambiguous situation.
January 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29339504/complement-pathway-gene-activation-and-rising-circulating-immune-complexes-characterize-early-disease-in-hiv-associated-tuberculosis
#9
Hanif Esmail, Rachel P Lai, Maia Lesosky, Katalin A Wilkinson, Christine M Graham, Stuart Horswell, Anna K Coussens, Clifton E Barry, Anne O'Garra, Robert J Wilkinson
The transition between latent and active tuberculosis (TB) occurs before symptom onset. Better understanding of the early events in subclinical disease will facilitate the development of diagnostics and interventions that improve TB control. This is particularly relevant in the context of HIV-1 coinfection where progression of TB is more likely. In a recent study using [18 F]-fluoro-2-deoxy-d-glucose positron emission/computed tomography (FDG-PET/CT) on 35 asymptomatic, HIV-1-infected adults, we identified 10 participants with radiographic evidence of subclinical disease, significantly more likely to progress than the 25 participants without...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29326867/cavitary-lung-lesion-suspicious-for-malignancy-reveals-mycobacterium-xenopi
#10
Sumit Fogla, Vaishali M Pansare, Luis G Camero, Uzma Syeda, Naveen Patil, Arun Chaudhury
We report the case of a 68-year-old gentleman who presented with musculoskeletal chest pain which appeared suddenly when he bent over with his dog. The chest pain was localized to the left lower chest and increased with movement and deep breathing. The patient did not complain weight loss, night sweat, fever or chill. He complained of mild cough, with expectoration of whitish mucus. Imaging revealed cavitary chest lesion in the right upper lobe, which was initially suspected to be lung cancer. The patient had a 50-year-old history of smoking 2 packs per day...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29215403/suv-as-a-possible-predictor-of-disease-extent-and-therapy-duration-in-complex-tuberculosis
#11
David Lang, Helmut Huber, Bernhard Kaiser, Irene Virgolini, Bernd Lamprecht, Michael Gabriel
OBJECTIVE: F-FDG PET/CT provides information on disease extension and activity in neoplastic and inflammatory conditions. So far, little is known about whether SUVmax of a reference lesion can allow a prognosis to be given regarding patient-specific outcome parameters in complex cases of tuberculosis (TB). METHODS: We retrospectively identified 37 patients (21 men, 16 women; mean age, 50.4 years) who underwent F-FDG PET/CT for the evaluation of active TB before treatment initiation...
February 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29199704/solitary-pulmonary-nodule-evaluation-in-regions-endemic-for-infectious-diseases-do-regional-variations-impact-the-effectiveness-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#12
N C Purandare, C S Pramesh, J P Agarwal, A Agrawal, S Shah, K Prabhash, G Karimundackal, S Jiwnani, S Tandon, V Rangarajan
BACKGROUND: Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has become a preferred imaging modality for the evaluation of solitary pulmonary nodule (SPN), particularly in the developed world. Since FDG can concentrate in infective/inflammatory lesions, the diagnostic utility of FDG-PET can be questioned, particularly in regions endemic for infectious decisions. AIM: To evaluate the accuracy of FDG-PET/CT in evaluation of SPNs in a population endemic for infectious disease and to assess if regional variations have an impact on its effectiveness...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29157383/18f-fluoro-2-deoxy-d-glucose-pet-computed-tomography-evaluation-of-lung-cancer-in-populations-with-high-prevalence-of-tuberculosis-and-other-granulomatous-disease
#13
REVIEW
Alexandre Niyonkuru, Khamis Hassan Bakari, Xiaoli Lan
Pulmonary tuberculosis infects one-third of world's population and is responsible for the high mortality and morbidity in developing countries. The presence of a high number of macrophages and lymphocytes in active tuberculosis granulomas is associated with high uptake of 18F-fluoro-2-deoxy-d-glucose on PET imaging mimicking lung cancer. In many cases, radiological features of pulmonary tuberculosis are undistinguishable from lung cancer, which makes the diagnosis difficult. Clinical history and computed tomographic (CT) findings on a hybrid PET/CT are as important as findings on a PET in the diagnosis of lung cancer...
January 2018: PET Clinics
https://www.readbyqxmd.com/read/29142348/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-tuberculosis-spectrum-of-manifestations
#14
Krishan Kant Agarwal, Abhishek Behera, Rakesh Kumar, Chandrasekhar Bal
The objective of this article is to provide an illustrative tutorial highlighting the utility of18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (18 F-FDG-PET/CT) imaging to detect spectrum of manifestations in patients with tuberculosis (TB). FDG-PET/CT is a powerful tool for early diagnosis, measuring the extent of disease (staging), and consequently for evaluation of response to therapy in patients with TB.
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29137875/contribution-of-11-c-choline-pet-ct-in-prostate-carcinoma-biochemical-relapse-with-serum-psa-level-below-1-ng-ml
#15
F J Gómez-de la Fuente, I Martínez-Rodríguez, M de Arcocha-Torres, R Quirce, J Jiménez-Bonilla, N Martínez-Amador, I Banzo
OBJECTIVE: (11)C-choline PET/CT has demonstrated good results in the restaging of prostate cancer (PCa) with high serum prostate specific antigen (PSA), but its use in patients with low serum PSA is controversial. Our aim was to evaluate the contribution of (11)C-choline PET/CT in patients with PCa, biochemical relapse and PSA <1 ng/ml. MATERIAL AND METHOD: Fifty consecutive patients (mean age: 65.9±5.6 years) with biochemical relapse of PCa and serum PSA <1ng/ml were evaluated retrospectively...
November 11, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29050771/host-blood-rna-signatures-predict-the-outcome-of-tuberculosis-treatment
#16
Ethan G Thompson, Ying Du, Stephanus T Malherbe, Smitha Shankar, Jackie Braun, Joe Valvo, Katharina Ronacher, Gerard Tromp, David L Tabb, David Alland, Shubhada Shenai, Laura E Via, James Warwick, Alan Aderem, Thomas J Scriba, Jill Winter, Gerhard Walzl, Daniel E Zak
Biomarkers for tuberculosis treatment outcome will assist in guiding individualized treatment and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of whole blood from a well-characterized TB treatment cohort was performed. Application of a validated transcriptional correlate of risk for TB revealed symmetry in host gene expression during progression from latent TB infection to active TB disease and resolution of disease during treatment, including return to control levels after drug therapy...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29019325/ambiguity-of-whole-body-pet-ct-scans-in-diagnosis-of-co-existing-tuberculosis-and-malignancy-is-histopathological-confirmation-mandatory
#17
Prekshi Chaudhary, Sweety Gupta, Nitin Leekha, Ravi S Rajendra, Shiv S Mishra, Vandana Arora, Sudarsan De, Sandeep Agarwal
INTRODUCTION: Whole body PET CT is an important investigation tool in malignancy patients and helps in ascertaining the metabolic activity and exact stage of the disease. However, like any other investigation, false positive results do exist and certain diseases other than cancer may show increased uptake. Hence, a careful evaluation of PET CT and clinical correlation in malignancy patients is a must to accomplish the suitable treatment. METHODS: In this retrospective observational study, seven cases of cancer with concomitant tuberculosis were included...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28962139/asymptomatic-pulmonary-tuberculosis-mimicking-lung-cancer-on-imaging-a-retrospective-study
#18
Shan Lang, Junping Sun, Xuning Wang, Yongjiu Xiao, Juan Wang, Mingyue Zhang, Ting Ao, Jianxin Wang
Asymptomatic pulmonary tuberculosis (PTB) mimicking lung cancer is rare and has been documented in few studies. Accurately diagnosing this atypical disease remains an enormous challenge for clinicians. The aim of the present study was to characterize asymptomatic patients with PTB who were initially diagnosed with lung cancer according to their chest computer tomography (CT) or whole-body 18F-fludeoxyglucose-positron emission tomography-computer tomography (PET-CT) presentations. The clinical characteristics and radiographic features of patients with PTB were analyzed and compared to those of patients with lung cancer...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28947646/rhesus-macaques-are-more-susceptible-to-progressive-tuberculosis-than-cynomolgus-macaques-a-quantitative-comparison
#19
Pauline Maiello, Robert M DiFazio, Anthony M Cadena, Mark A Rodgers, Philana Ling Lin, Charles A Scanga, JoAnne L Flynn
In the past 2 decades, it has become increasingly clear that nonhuman primates, specifically macaques, are useful models for human tuberculosis (TB). Several macaque species have been used for TB studies, and questions remain about the similarities and differences in TB pathogenesis among macaque species, which can complicate decisions about the best species for a specific experiment. Here we provide a quantitative assessment, using serial positron emission tomography and computed tomography (PET-CT) imaging and precise quantitative determination of bacterial burdens of low-dose Mycobacterium tuberculosis infection in cynomolgus macaques of Chinese origin, rhesus macaques of Chinese origin, and Mauritian cynomolgus macaques...
February 2018: Infection and Immunity
https://www.readbyqxmd.com/read/28932548/predictors-of-conversion-to-thoracotomy-during-video-assisted-thoracoscopic-surgery-lobectomy-in-lung-cancer-additional-predictive-value-of-fdg-pet-ct-in-a-tuberculosis-endemic-region
#20
Chun Geun Lim, Kyung Min Shin, Ji Seun Lim, Jae Kwang Lim, Hye Jung Kim, Won Hwa Kim, Seung Hyun Cho, Seung Ick Cha, Eung Bae Lee, Yangki Seock, Shin Young Jeong
BACKGROUND: To evaluate the added clinical value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scans to chest CT imaging in predicting the conversion to thoracotomy during video-assisted thoracoscopic surgery (VATS) lobectomy in patients with lung cancer. METHODS: This is a retrospective study of 235 consecutive patients who underwent planned VATS lobectomy for primary lung cancer between 2011 and 2015. CT images were interpreted in terms of the presence and the attenuation of peribronchial lymph nodes (PLN) and peribronchial cuffs of soft (PCS) tissue, pleural calcification, and parenchymal calcified nodule...
August 2017: Journal of Thoracic Disease
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