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Tuberculosis pet-ct

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https://www.readbyqxmd.com/read/28500120/the-clinical-conundrum-of-diagnosing-and-treating-systemic-sarcoidosis-in-a-high-tb-burden-area
#1
Krishnadas Thulasidoss, Lavanya Asokan, Piyush Chandra, Pravinkumar Rejliwal
A 53-year-old woman from Southern India presented with weight loss, anorexia, fever and asthenia. Whole body positron emission tomography/computed tomography (PET-CT) showed fluorodeoxyglucose-avid mediastinal and abdominal lymphadenopathy with hepatic, splenic, parotid and lacrimal glandular inflammations. Endoscopic ultrasound-guided fine needle aspiration of subcarinal lymph node showed non-caseating granulomas. Initial serum ACE level was elevated but with normal calcium. Despite the suspicion of sarcoidosis, a trial of antituberculosis therapy was started empirically due to similar presentations of disseminated tuberculosis (TB) in this high endemic area...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28489769/retroperitoneal-metastatic-poorly-differentiated-carcinoma-with-%C3%AE-human-chorionic-gonadotropin-secretion-presenting-as-a-psoas-abscess-a-case-report-and-review-of-the-literature
#2
Bingjin Wang, Weifang Liu, Zengwu Shao, Xianlin Zeng
RATIONALE: Psoas abscesses generally arise from a contiguous intra-abdominal or pelvic infectious process or hematogenous spreading of bacteria. The serum β-human chorionic gonadotropin has been used to detect normal or ectopic pregnancy. It also can be utilized in following up carcinomas. PATIENT CONCERNS: Here, we reported a case of a 47-year-old woman who presented with a left psoas mass presumptively diagnosed as an abscess secondary to lumbar tuberculosis In addition, the patient had abnormal increase of β-human chorionic gonadotropin...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28487426/digitally-barcoding-mycobacterium-tuberculosis-reveals-in-vivo-infection-dynamics-in-the-macaque-model-of-tuberculosis
#3
Constance J Martin, Anthony M Cadena, Vivian W Leung, Philana Ling Lin, Pauline Maiello, Nathan Hicks, Michael R Chase, JoAnne L Flynn, Sarah M Fortune
Infection with Mycobacterium tuberculosis causes a spectrum of outcomes; the majority of individuals contain but do not eliminate the infection, while a small subset present with primary active tuberculosis (TB) disease. This variability in infection outcomes is recapitulated at the granuloma level within each host, such that some sites of infection can be fully cleared while others progress. Understanding the spectrum of TB outcomes requires new tools to deconstruct the mechanisms underlying differences in granuloma fate...
May 9, 2017: MBio
https://www.readbyqxmd.com/read/28458310/peripancreatic-tuberculous-lymphadenitis-diagnosed-via-endoscopic-ultrasound-guided-fine-needle-aspiration-and-polymerase-chain-reaction
#4
Jun Arai, Katsuya Kitamura, Akira Yamamiya, Yu Ishii, Tomohiro Nomoto, Tadashi Honma, Hiroo Ishida, Eisuke Shiozawa, Masafumi Takimoto, Hitoshi Yoshida
We performed endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) on a patient presenting with an asymptomatic peripancreatic mass-like lesion. The aspiration cytologic finding was class II. On positron emission tomography-computed tomography (PET-CT), there were hot spots in the left supra-clavicular lymph node and the peripancreatic lesion. A whole biopsy of the left supra-clavicular lymph node revealed tuberculous lymphadenitis. Polymerase chain reaction (PCR) using tissue obtained via EUS-FNA showed that the peripancreatic mass-like lesion was also positive for tuberculosis...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28426991/clinical-usefulness-of-18-f-fdg-pet-ct-for-initial-staging-and-assessment-of-treatment-efficacy-in-patients-with-lymph-node-tuberculosis
#5
Nicolas Lefebvre, Xavier Argemi, Nicolas Meyer, Joy Mootien, Nawal Douiri, Stefania Sferrazza-Mandala, Frédéric Schramm, Noëlle Weingertner, Daniel Christmann, Yves Hansmann, Alessio Imperiale
INTRODUCTION: Few studies have evaluated the promising role of (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (PET) and PET/computed tomography FDG PET/CT in evaluating and monitoring treatment response in patients with lymph node tuberculosis (LNTB). The aim of this clinical investigation was to assess the clinical usefulness of FDG PET/CT for initial tuberculosis staging and to determine the prognostic value of the decrease of (18)F-FDG uptake during antibiotic treatment in LNTB patients...
April 8, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28417858/-18-f-fdg-pet-ct-imaging-of-thoracic-and-extrathoracic-tuberculosis-in-children
#6
REVIEW
Matthieu Pelletier-Galarneau, Patrick Martineau, Lionel S Zuckier, Xuan Pham, Raymond Lambert, Sophie Turpin
Tuberculosis (TB) remains a major health problem, affecting approximately one-third of the world׳s population. The tubercle bacillus can affect virtually any organ of the human body and if left untreated can lead to severe morbidity and death. Diagnosis of active TB is challenging, especially in children. As a "great imitator," the disease can mimic numerous other pathologies, both clinically and at imaging. Although recognition of active TB is crucial to initiate adequate treatment in a timely fashion, thereby preventing transmission of disease, differentiation of active and quiescent disease is not always straightforward...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28394836/18f-fdg-pet-ct-of-tuberculosis-meningitis-and-carotid-pseudoaneurysm
#7
Kasturi Rangan, Mudalsha Ravina, Nitin Yadav, Ajay Singh Suraj, Sanjay Gambhir
A 26-year-old woman presented with a headache, left-sided weakness of the body, and pulsatile swelling above the sternal notch. She was treated for abdominal tuberculosis in the past, two years later she developed miliary tuberculosis and was put on modified regimen of antitubercular drugs in view of drug induced hepatitis. Ultrasound neck revealed saccular aneurysm measuring 4 x 3 cm, located in between common carotid arteries with an eccentric thrombus. MRI brain revealed multiple tuberculoma with thick basal meningeal enhancement...
June 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28287534/rapid-one-step-enzymatic-synthesis-and-all-aqueous-purification-of-trehalose-analogues
#8
Lisa M Meints, Anne W Poston, Brent F Piligian, Claire D Olson, Katherine S Badger, Peter J Woodruff, Benjamin M Swarts
Chemically modified versions of trehalose, or trehalose analogues, have applications in biology, biotechnology, and pharmaceutical science, among other fields. For instance, trehalose analogues bearing detectable tags have been used to detect Mycobacterium tuberculosis and may have applications as tuberculosis diagnostic imaging agents. Hydrolytically stable versions of trehalose are also being pursued due to their potential for use as non-caloric sweeteners and bioprotective agents. Despite the appeal of this class of compounds for various applications, their potential remains unfulfilled due to the lack of a robust route for their production...
February 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28282998/non-traumatic-vertebral-lesions-incremental-utility-of-pet-ct-over-mri-and-fnac-in-a-suggested-diagnostic-algorithm
#9
Rajesh Meena, Ashish Aggarwal, Anish Bhattacharya, Vivek Gupta, Sivashanmugam Dhandapani, Rajesh Chhabra
OBJECTIVE: To prospectively compare positron emission tomography-computed tomography (PET-CT) with conventional magnetic resonance imaging (MRI) and FNAC for diagnosis of non- traumatic vertebral lesions fracture in countries like India where tuberculosis is endemic. METHODS: Fifty four patients with non-traumatic spontaneous vertebral lesions were prospectively studied. All patients underwent CEMRI focusing on the spinal lesions, whole-body PET-CT and FNAC.Results were then analysed and compared with final diagnosis obtained either by FNAC or clinical follow up...
March 10, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28077735/tuberculosis-mimicking-metastases-by-malignancy-in-fdg-pet-ct
#10
B Liu, L Dong, X Wang, T Han, Q Lin, M Liu
No abstract text is available yet for this article.
March 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27853089/disseminated-mycobacterium-tuberculosis-infection-masquerading-as-metastasis-after-heavy-ion-radiotherapy-for-prostate-cancer
#11
Masaru Ando, Yutaka Mukai, Ryo-Ichi Ushijima, Yoshiyuki Shioyama, Kenji Umeki, Fumito Okada, Shin-Ichi Nureki, Hiromitsu Mimata, Jun-Ichi Kadota
Fluorodeoxyglucose (FDG)-positron emission tomography with computed tomography (FDG-PET/CT) is useful in disease monitoring of malignancies after therapy, while an FDG uptake may also be present in benign diseases. We herein demonstrate a case of disseminated Mycobacterium tuberculosis mimicking systemic metastasis of prostate cancer. This case highlights that clinicians should consider Mycobacterium tuberculosis in patients with prostate cancer who demonstrate multifocal FDG uptakes masquerading as metastasis, even when the chest photographs reveal a normal appearance and a sputum examination demonstrates negative results...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27772758/role-of-18-f-fdg-pet-in-demonstrating-disease-burden-in-patients-with-tuberculous-meningitis
#12
COMPARATIVE STUDY
Sanjay Gambhir, Mritunjai Kumar, Mudalsha Ravina, Sanjeev Kumar Bhoi, Jayantee Kalita, U K Misra
OBJECTIVE: To study the role of (18)fluoro-deoxy glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan in documenting the disease burden in patients with tuberculous meningitis (TBM), and compare these findings with conventional imaging and magnetic resonance imaging (MRI). SUBJECTS AND METHODS: Ten patients with definite TBM were prospectively recruited. The severity of TBM was graded into stage I to III. The patients were subjected to whole body (18)F-FDG PET/CT imaging and MRI brain...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27638826/-pulmonary-granulomatous-diseases-and-pulmonary-manifestations-of-systemic-granulomatous-disease-including-tuberculosis-and-nontuberculous-mycobacteriosis
#13
S Piel, M Kreuter, F Herth, H-U Kauczor, C-P Heußel
CLINICAL/METHODICAL ISSUE: Granulomas as signs of specific inflammation of the lungs are found in various diseases with pulmonary manifestations and represent an important imaging finding. STANDARD RADIOLOGICAL METHODS: The standard imaging modality for the work-up of granulomatous diseases of the lungs is most often thin-slice computed tomography (CT). There are a few instances, e. g. tuberculosis, sarcoidosis and silicosis, where a chest radiograph still plays an important role...
October 2016: Der Radiologe
https://www.readbyqxmd.com/read/27638825/-skeletal-sarcoidosis
#14
J Freyschmidt, P Freyschmidt
OBJECTIVE: Presentation of the etiology, pathology, clinical course, radiology and differential diagnostics of skeletal sarcoidosis. PATHOANATOMICAL PRINCIPLES: Noncaseating epithelioid cell granulomas can trigger solitary, multiple or disseminated osteolysis, reactive osteosclerosis and/or granulomatous synovitis. INCIDENCE: The incidence of sarcoidosis is 10-12 per 100,000 inhabitants per year. Skeletal involvement is approximately 14 %...
October 2016: Der Radiologe
https://www.readbyqxmd.com/read/27603341/increased-18f-fdg-uptake-of-heterotopic-pancreatitis-in-the-small-intestine-a-care-compliant-case-report
#15
Maomei Ruan, Min Liu, Lingxiao Cheng, Wenhui Xie, Libo Chen
BACKGROUD: Heterotopic pancreas (HP), a relatively uncommon congenital anomaly, is rarely noted during F-FDG positron-emission tomography/computed tomography (PET/CT) scan. METHODS: A 60-year-old woman was referred to our hospital due to a 10-day history of abdominal pain with elevated levels of serum amylase and lipase. Abdominal CT and ultrasound examinations were negative. In order to search for the cause, an F-FDG PET/CT whole body scan was suggested to an old woman revealing the presence of F-FDG accumulating nodule in small intestine...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27595324/persisting-positron-emission-tomography-lesion-activity-and-mycobacterium-tuberculosis-mrna-after-tuberculosis-cure
#16
Stephanus T Malherbe, Shubhada Shenai, Katharina Ronacher, Andre G Loxton, Gregory Dolganov, Magdalena Kriel, Tran Van, Ray Y Chen, James Warwick, Laura E Via, Taeksun Song, Myungsun Lee, Gary Schoolnik, Gerard Tromp, David Alland, Clifton E Barry, Jill Winter, Gerhard Walzl, Lance Lucas, Gian van der Spuy, Kim Stanley, Lani Theart, Bronwyn Smith, Nelita Burger, Caroline G G Beltran, Elizna Maasdorp, Annare Ellmann, Hongjo Choi, Joonsung Joh, Lori E Dodd, Brian Allwood, Coenie Kogelenberg, Morné Vorster, Stephanie Griffith-Richards
The absence of a gold standard to determine when antibiotics induce a sterilizing cure has confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We detected positron emission tomography and computerized tomography (PET-CT) imaging response patterns consistent with active disease, along with the presence of Mycobacterium tuberculosis (MTB) mRNA in sputum and bronchoalveolar lavage samples, in a substantial proportion of adult, HIV-negative patients with PTB after a standard 6-month treatment plus 1 year follow-up, including patients with a durable cure and others who later developed recurrent disease...
October 2016: Nature Medicine
https://www.readbyqxmd.com/read/27437932/observed-patterns-of-systemic-disease-on-pet-ct-scan-in-patients-with-presumed-ocular-tuberculosis-findings-and-hypotheses
#17
Salil Mehta
PURPOSE: To report the clinical, investigational and PET/CT scan findings of patients with presumed ocular tuberculosis and suggest a hypotheses for the pathogenesis. METHODS: Retrospective case review. Included were 10 males and 17 females with an age range: 23-71 years. RESULTS: Clinical findings include granulomatous or non-granulomatous anterior uveitis, intermediate uveitis, panuveitis, vasculitis, and multifocal serpiginous-like choroidopathy...
July 20, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27379816/pet-ct-identifies-reactivation-risk-in-cynomolgus-macaques-with-latent-m-tuberculosis
#18
Philana Ling Lin, Pauline Maiello, Hannah P Gideon, M Teresa Coleman, Anthony M Cadena, Mark A Rodgers, Robert Gregg, Melanie O'Malley, Jaime Tomko, Daniel Fillmore, L James Frye, Tara Rutledge, Robert M DiFazio, Christopher Janssen, Edwin Klein, Peter L Andersen, Sarah M Fortune, JoAnne L Flynn
Mycobacterium tuberculosis infection presents across a spectrum in humans, from latent infection to active tuberculosis. Among those with latent tuberculosis, it is now recognized that there is also a spectrum of infection and this likely contributes to the variable risk of reactivation tuberculosis. Here, functional imaging with 18F-fluorodeoxygluose positron emission tomography and computed tomography (PET CT) of cynomolgus macaques with latent M. tuberculosis infection was used to characterize the features of reactivation after tumor necrosis factor (TNF) neutralization and determine which imaging characteristics before TNF neutralization distinguish reactivation risk...
July 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27358601/an-old-enemy-not-to-be-forgotten-during-pet-ct-scanning-of-cancer-patients-tuberculosis
#19
Ahmet Taner Sümbül, Ahmet Sezer, Hüseyin Abali, Bilge Gültepe, Emrah Koçer, Mehmet Reyhan, Önder Tonyalı, Özgür Özyilkan
AIM OF THE STUDY: Positron emission tomography-computed tomography (PET CT) scan is commonly used in current medical oncology practice as an imaging method. In this study we present data from cancer patients who were followed at our clinic and suspected of having tuberculosis during PET CT scanning. After the biopsy, they were diagnosed with concomitant tuberculosis. MATERIAL AND METHODS: In this study, 14 patients who applied to our clinic and followed up due to cancer, and had PET CT scanning for the preliminary staging or further evaluation, were included...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27217666/multiple-bony-metastatic-lesions-and-evaluation-of-primary-case-records-of-a-cancer-research-centre
#20
Deepak Sundriyal, Nikhil Shirsi, Arun Gera, Satish Bansal, Sumedha Kotwal, Ramesh Dawar
During 2012-13, we diagnosed 4 patients with extensive skeletal tuberculosis (TB) who were referred to us as cases of bony metastasis with unknown primary. Radiological investigations done outside favoured a diagnosis of disseminated malignancy. Positron emission tomography/computed tomography (PET/CT) scan performed in our institute for localization of primary lesion also suggested metastatic disease. There was no evidence of malignancy on histo-pathological examination (HPE) of the involved sites. The diagnosis of TB was established on characteristics HPE...
September 2015: Indian Journal of Surgical Oncology
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