Edouard G Mills, Natalie Ertl, Matthew B Wall, Layla Thurston, Lisa Yang, Sofiya Suladze, Tia Hunjan, Maria Phylactou, Bijal Patel, Beatrice Muzi, Dena Ettehad, Paul A Bassett, Jonathan Howard, Eugenii A Rabiner, Paul Bech, Ali Abbara, David Goldmeier, Alexander N Comninos, Waljit S Dhillo
IMPORTANCE: The human physiological sexual response is crucial for reward, satisfaction, and reproduction. Disruption of the associated neurophysiological pathways predisposes to low sexual desire; the most prevalent psychological form is hypoactive sexual desire disorder (HSDD), which affects 8% of men but currently has no effective pharmacological treatment options. The reproductive neuropeptide kisspeptin offers a putative therapeutic target, owing to emerging understanding of its role in reproductive behavior...
February 1, 2023: JAMA Network Open