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https://www.readbyqxmd.com/read/27596360/recombinant-human-relaxin-versus-placebo-for-cervical-ripening-a-double-blind-randomised-trial-in-pregnant-women-scheduled-for-induction-of-labour
#1
Gerson Weiss, Sam Teichman, Dennis Stewart, David Nader, Susan Wood, Peter Breining, Elaine Unemori
BACKGROUND: Nonclinical studies indicate that the hormone relaxin is a good candidate for a safe cervical ripening agent that does not cause uterine contractions. METHODS: This Phase II study (conducted November 2, 2005-October 20, 2006) was a randomised, double blind, placebo controlled trial testing 24-h intravenous infusion of serelaxin (recombinant human relaxin) or placebo for cervical ripening in 72 healthy, primiparous women. Eligible subjects had a singleton pregnancy ≥40 weeks, were planned for elective induction, had vertex presentation of the fetus, intact membranes and a Bishop score at screening ≤4...
2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27539200/a-mixed-methods-study-of-clinical-information-availability-in-obstetric-triage-and-prenatal-offices
#2
Chad D Meyerhoefer, Susan A Sherer, Mary E Deily, Shin-Yi Chou, Lizhong Peng, Tianyan Hu, Marion Nihen, Michael Sheinberg, Donald Levick
OBJECTIVE: To determine the effect of availability of clinical information from an integrated electronic health record system on pregnancy outcomes at the point of care. MATERIALS AND METHODS: We used provider interviews and surveys to evaluate the availability of pregnancy-related clinical information in ambulatory practices and the hospital, and applied multiple regression to determine whether greater clinical information availability is associated with improvements in pregnancy outcomes and changes in care processes...
August 18, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27379299/protective-effects-of-tualang-honey-against-oxidative-stress-and-anxiety-like-behaviour-in-stressed-ovariectomized-rats
#3
Badriya Al-Rahbi, Rahimah Zakaria, Zahiruddin Othman, Asma' Hassan, Asma Hayati Ahmad
The present study aims to evaluate the antioxidant and anxiolytic-like effect of Tualang honey in stressed ovariectomized (OVX) rats. The animals were divided into; (i) nonstressed sham-operated control rats, (ii) sham-operated control rats exposed to stress, (iii) nonstressed OVX rats, (iv) OVX rats exposed to stress, (v) OVX rats exposed to stress and treated with 17 β-oestradiol (E2) (20 μg daily, sc), and (vi) OVX rats exposed to stress and treated with Tualang honey (0.2 g/kg body weight, orally)...
2014: International Scholarly Research Notices
https://www.readbyqxmd.com/read/27340578/preeclampsia-a-possible-complication-of-primary-hyperparathyroidism
#4
Bader Abdullah Alharbi, Mohammed Ali Alqahtani, Mohammed Hmoud, Essam Awadh Alhejaili, Reema Badros
Background. Primary hyperparathyroidism is rare in pregnancy. An association between primary hyperparathyroidism and preeclampsia has been reported in few cases worldwide. Case. A 28-year-old woman (gravida 2, para 0, and abortus 1) in her 27th week of gestation was hospitalized due to a high reading of blood pressure (194/115 mmHg) that was not accompanied by any symptoms or signs of preeclampsia. Incidentally, she was found to have a high adjusted calcium and serum parathyroid hormone (PTH) level during admission...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27295202/cd4-t-cells-confer-anxiolytic-and-antidepressant-like-effects-but-enhance-fear-memory-processes-in-rag2-mice
#5
Sarah M Clark, Jennifer A Soroka, Chang Song, Xin Li, Leonardo H Tonelli
Accumulating evidence supports a role of T cells in behavioral stress responsiveness. Our laboratory previously reported that lymphocyte deficient Rag2(-/-) mice on a BALB/c background display resilience to maladaptive stress responses when compared with immune competent mice in the predator odor exposure (POE) paradigm, while exhibiting similar behavior in a cued fear-conditioning (FC) paradigm. In the present study, Rag2(-/-) mice on a C57BL/6 background were assessed in the same behavioral paradigms, as well as additional tests of anxiety and depressive-like behavior...
May 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/27276861/doppler-changes-as-the-earliest-parameter-in-fetal-surveillance-to-detect-fetal-compromise-in-intrauterine-growth-restricted-fetuses
#6
Saloni Bansal, Deepika Deka, Vatsla Dhadwal, Rajiv Mahendru
INTRODUCTION: It is estimated that 3-10% of infants are growth restricted. Growth disturbances may have long-term issues. Doppler allows insight into the fetal response to intrauterine stress. OBJECTIVE: The aim of this study was to detect fetal compromise in intrauterine growth-restricted (IUGR) fetuses by means of biophysical profile (BPP) vis-à-vis Doppler velocimetry studies of the fetal umbilical artery, and to find out which of the two is a better and earlier predictor of fetal compromise...
January 2016: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/27184383/combined-effects-of-acamprosate-and-escitalopram-on-ethanol-consumption-in-mice
#7
Ada Man-Choi Ho, Yanyan Qiu, Yun-Fang Jia, Felipe S Aguiar, David J Hinton, Victor M Karpyak, Richard M Weinshilboum, Doo-Sup Choi
BACKGROUND: Major depression is one of the most prevalent psychiatry comorbidities of alcohol use disorders (AUD). As negative emotions can trigger craving and increase the risk of relapse, treatments that target both conditions simultaneously may augment treatment success. Previous studies showed a potential synergistic effect of Food and Drug Administration approved medication for AUD acamprosate and the antidepressant escitalopram. In this study, we investigated the effects of combining acamprosate and escitalopram on ethanol (EtOH) consumption in stress-induced depressed mice...
July 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27119005/tualang-honey-attenuates-noise-stress-induced-memory-deficits-in-aged-rats
#8
Khairunnuur Fairuz Azman, Rahimah Zakaria, Che Badariah Abdul Aziz, Zahiruddin Othman
Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved. This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. Tualang honey supplementation was given orally, 200 mg/kg body weight for 28 days. Rats in the stress group were subjected to loud noise, 100 dB(A), 4 hours daily for 14 days. All rats were subjected to novel object recognition test for evaluation of memory performance...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27048754/chronic-intermittent-ethanol-exposure-during-adolescence-effects-on-stress-induced-social-alterations-and-social-drinking-in-adulthood
#9
REVIEW
Elena I Varlinskaya, Esther U Kim, Linda P Spear
We previously observed lasting and sex-specific detrimental consequences of early adolescent intermittent ethanol exposure (AIE), with male, but not female, rats showing social anxiety-like alterations when tested as adults. The present study used Sprague Dawley rats to assess whether social alterations induced by AIE (3.5g/kg, intragastrically, every other day, between postnatal days [P] 25-45) are further exacerbated by stressors later in life. Another aim was to determine whether AIE alone or in combination with stress influenced intake of a sweetened ethanol solution (Experiment 1) or a sweetened solution ("supersac") alone (Experiment 2) under social circumstances...
April 2, 2016: Brain Research
https://www.readbyqxmd.com/read/27045550/microrna-326-acts-as-a-molecular-switch-in-the-regulation-of-midbrain-urocortin-1-expression
#10
Armaz Aschrafi, Jan M Verheijen, Peter M Gordebeke, Nikkie F Olde Loohuis, Kelly Menting, Amanda Jager, Miklos Palkovits, Bram Geenen, Aron Kos, Gerard J M Martens, Jeffrey C Glennon, Barry B Kaplan, Balázs Gaszner, Tamas Kozicz
BACKGROUND: Altered levels of urocortin 1 (Ucn1) in the centrally projecting Edinger-Westphal nucleus (EWcp) of depressed suicide attempters or completers mediate the brain's response to stress, while the mechanism regulating Ucn1 expression is unknown. We tested the hypothesis that microRNAs (miRNAs), which are vital fine-tuners of gene expression during the brain's response to stress, have the capacity to modulate Ucn1 expression. METHODS: Computational analysis revealed that the Ucn1 3' untranslated region contained a conserved binding site for miR-326...
August 2016: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/27042185/effects-of-xiaoyaosan-on-stress-induced-anxiety-like-behavior-in-rats-involvement-of-crf1-receptor
#11
You-Ming Jiang, Xiao-Juan Li, Zhen-Zhi Meng, Yue-Yun Liu, Hong-Bo Zhao, Na Li, Zhi-Yi Yan, Qing-Yu Ma, Han-Ting Zhang, Jia-Xu Chen
Background. Compared with antidepressant activity of Xiaoyaosan, the role of Xiaoyaosan in anxiety has been poorly studied. Objective. To observe the effects of Xiaoyaosan on anxiety-like behavior induced by chronic immobilization stress (CIS) and further explore whether these effects were related to CRF1R signaling. Methods. Adult male SD rats were randomly assigned to five groups (n = 12): the nonstressed control group, vehicle-treated (saline, p.o.) group, Xiaoyaosan-treated (3.854 g/kg, p.o.) group, vehicle-treated (surgery) group, and antalarmin-treated (surgery) group...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26960703/evaluating-the-obstetrical-implications-of-antenatal-testing-for-women-with-morbid-obesity-maternal-and-fetal-outcomes-of-increased-surveillance
#12
P Kaitlyn Edelson, Jamie A Bastek, Lisa D Levine
Objectives Despite limited data, antenatal testing has been initiated in many institutions for women with morbid obesity given their increased risk of stillbirth. Therefore, our objective was to evaluate the obstetrical implications of antenatal testing in the morbidly obese population. Study Design We performed a retrospective cohort study of women undergoing antenatal testing from January 2011 through December 2012 who delivered at our institution. The exposed group was women undergoing antenatal testing with morbid obesity (body mass index [BMI] ≥ 40 kg/m(2))...
July 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/26957141/cardiovascular-safety-assessments-in-the-cynomolgus-monkey-unmasking-potential-background-arrhythmias-in-general-toxicity-studies
#13
Andrea Greiter-Wilke, Ted Baird, Kyle O'Donohue, Annette Koerner
INTRODUCTION: We describe experience with an unexpectedly high background incidence of atrioventricular block (AVB) observed in Mauritian cynomolgus monkeys (MCM) during preclinical safety assessment for bitopertin, a glycine-transporter-1 inhibitor. METHODS: Preclinical ECGs were reviewed to assess potential effects on cardiac conductivity, specifically AVB. RESULTS: Bitopertin administration in Chinese/Vietnamese monkeys (CVM; n=46) or MCM (n=64, from all relevant studies) revealed dose-dependent hypoactivity with a lack of expected increases in heart rate in response to chair-restraint during ECG recordings...
September 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/26866533/social-stress-facilitates-risk-in-youths
#14
Jeremy P Jamieson, Wendy Berry Mendes
This research examined the influence of social stress on risk processes in youths. Study 1 (N = 89) randomly assigned male youths to perform either a stressful social-evaluative or nonstressful control task followed by a risk-perception measure. Compared to controls, social stress participants perceived less risk in their environment. Study 2 (N = 188) extended findings by testing effects of social stress on risk perception in males and females, and across 3 age groups: teenagers (15-19), young adults (25-40), and older adults (60-75)...
April 2016: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/26721782/acute-fetal-behavioral-response-to-prenatal-yoga-a-single-blinded-randomized-controlled-trial-try-yoga
#15
RANDOMIZED CONTROLLED TRIAL
Shilpa Babbar, James B Hill, Karen B Williams, Maria Pinon, Suneet P Chauhan, Dev Maulik
BACKGROUND: In 2012, yoga was practiced by 20 million Americans, of whom 82% were women. A recent literature review on prenatal yoga noted a reduction in some pregnancy complications (ie, preterm birth, lumbar pain, and growth restriction) in those who practiced yoga; to date, there is no evidence on fetal response after yoga. OBJECTIVES: We aimed to characterize the acute changes in maternal and fetal response to prenatal yoga exercises using common standardized tests to assess the well-being of the maternal-fetal unit...
March 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26680735/central-apelin-mediates-stress-induced-gastrointestinal-motor-dysfunction-in-rats
#16
Mehmet Bülbül, V Nimet İzgüt-Uysal, Osman Sinen, İlknur Birsen, Gamze Tanrıöver
Apelin, an endogenous ligand for APJ receptor, has been reported to be upregulated in paraventricular nucleus (PVN) following stress. Central apelin is known to stimulate release of corticotropin-releasing factor (CRF) via APJ receptor. We tested the hypothesis that stress-induced gastrointestinal (GI) dysfunction is mediated by central apelin. We also assessed the effect of exogenous apelin on GI motility under nonstressed (NS) conditions in conscious rats. Prior to solid gastric emptying (GE) and colon transit (CT) measurements, APJ receptor antagonist F13A was centrally administered under NS conditions and following acute stress (AS), chronic homotypic stress (CHS), and chronic heterotypic stress (CHeS)...
February 15, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/26675825/modification-of-comt-dependent-pain-sensitivity-by-psychological-stress-and-sex
#17
Carolina B Meloto, Andrey V Bortsov, Eric Bair, Erika Helgeson, Cara Ostrom, Shad B Smith, Ronald Dubner, Gary D Slade, Roger B Fillingim, Joel D Greenspan, Richard Ohrbach, William Maixner, Samuel A McLean, Luda Diatchenko
Catecholamine-O-methyltransferase (COMT) is a polymorphic gene whose variants affect enzymatic activity and pain sensitivity via adrenergic pathways. Although COMT represents one of the most studied genes in human pain genetics, findings regarding its association with pain phenotypes are not always replicated. Here, we investigated if interactions among functional COMT haplotypes, stress, and sex can modify the effect of COMT genetic variants on pain sensitivity. We tested these interactions in a cross-sectional study, including 2 cohorts, one of 2972 subjects tested for thermal pain sensitivity (Orofacial Pain: Prospective Evaluation and Risk Assessment) and one of 948 subjects with clinical acute pain after motor vehicle collision (post-motor vehicle collision)...
April 2016: Pain
https://www.readbyqxmd.com/read/26602608/nonlinear-analysis-of-fetal-heart-rate-dynamics-in-fetuses-compromised-by-asymptomatic-partial-placental-abruption
#18
Won-Young Choi, Jeong-Kyu Hoh
INTRODUCTION: We analyzed fetal heart rate (FHR) parameters, dynamics, and outcomes in pregnancies with asymptomatic partial placental abruption (PPA) compared with those in normal pregnancies. METHODS: We examined nonstress test (NST) data acquired from 2003 to 2012 at our institution. Normal pregnancies (N = 170) and PPA cases (N = 17) were matched for gestational age, fetal sex, and mean FHR. NSTs were performed at 33-42 weeks of gestation. FHR parameters obtained from the NST and perinatal outcomes were analyzed using linear methods...
December 2015: Placenta
https://www.readbyqxmd.com/read/26572588/direct-intramuscular-fetal-or-maternal-antenatal-corticosteroid-therapy-short-time-effects-on-fetal-behavior-and-oxygenation-a-comparative-study
#19
Ivana Babović, Zoran Radojičić, Snežana Plešinac, Biljana Kastratović Kotlica, Radmila Sparić
OBJECTIVE: To compare the effects of antenatal administration of corticosteroids used in two different regimens, on fetal biophysical profile (BPP), baseline fetal heart rate (BFHR), nonstress test (NST) and perinatal outcomes. STUDY DESIGN: We evaluated the effects of single direct intramuscular (i.m.) fetal dose of dexamethasone (4 mg/kg), or four doses of 6 mg dexamethasone given to the mother 12 hours apart on the parameters of fetal BPP 0-4 hours before and after antenatal contraction stress (ACST)...
October 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26555518/growth-of-stressed-strains-of-four-non-o157-shiga-toxin-producing-escherichia-coli-serogroups-in-five-enrichment-broths
#20
COMPARATIVE STUDY
Bavo Verhaegen, Koen De Reu, Marc Heyndrickx, Inge Van Damme, Lieven De Zutter
The purpose of this study was to evaluate (i) the behavior of several strains of non-O157 Shiga toxin-producing Escherichia coli (STEC) serogroups (O26, O103, O111, and O145) exposed to different stress conditions and (ii) the growth dynamics of stressed and nonstressed non-O157 STEC cells in five enrichment media. STEC strains were exposed to acid, cold, and freeze stresses. Lethal and sublethal injuries were determined by plating in parallel on selective and nonselective agar media. Freeze stress (8 days, 20°C) caused the most lethal (95...
November 2015: Journal of Food Protection
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