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https://www.readbyqxmd.com/read/29777935/effect-of-different-alkyl-groups-on-excited-state-tautomerization-of-7ai-azaindole-h-2-o-a-theoretical-study
#1
Jiacheng Yi, Hua Fang
The effect of substituted alkyl groups at different substituted position on the first excited-state proton transfer of nR7AI-H2 O (n = 2-6; R = CH3 , C2 H5 , CF3 ) complexes were theoretically investigated at the TD-M06-2X/6-31 + G(d, p) level. Here n value denoted the substituted position Cn of R group. The replacement of alkyl R group had no effect on the features of HOMO and LUMO, but influenced the S0  → S1 adiabatic transition energies of the nR7AI-H2 O complex. Through computation, we found that the double proton transfer took place in a concerted but asynchronous protolysis pattern regardless of substituted group R and substituted position in the nR7AI-H2 O complex...
May 16, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29777773/progress-in-formulation-development-and-sterilisation-of-freeze-dried-oligodeoxynucleotide-loaded-gelatine-nanoparticles
#2
Katharina J Geh, Madlen Hubert, Gerhard Winter
Oligodeoxynucleotide (ODN)-loaded gelatine nanoparticles (GNPs) have proven their outstanding potential in the treatment of allergic diseases such as equine asthma and canine atopic dermatitis, which are appropriate models for the corresponding human diseases. To encourage the development of a marketable product, long term stability and sterility needs to be ensured. In this work, we aimed to advance freeze-drying options to stabilise ODN-loaded GNPs. Matrix-assisted laser desorption/ionisation mass spectrometry time-of-flight was implemented as a versatile tool to assess ODN stability...
May 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29777704/dietary-mung-bean-protein-reduces-high-fat-diet-induced-weight-gain-by-modulating-host-bile-acid-metabolism-in-a-gut-microbiota-dependent-manner
#3
Akiho Nakatani, Xuan Li, Junki Miyamoto, Miki Igarashi, Hitoshi Watanabe, Asuka Sutou, Keita Watanabe, Takayasu Motoyama, Nobuhiko Tachibana, Mitsutaka Kohno, Hiroshi Inoue, Ikuo Kimura
The 8-globulin-rich mung bean protein (MPI) suppresses hepatic lipogenesis in rodent models and reduces fasting plasma glucose and insulin levels in obese adults. However, its effects on mitigating high fat diet (HFD)-induced obesity and the mechanism underlying these effects remain to be elucidated. Herein, we examined the metabolic phenotype, intestinal bile acid (BA) pool, and gut microbiota of conventionally raised (CONV-R) male C57BL/6 mice and germ-free (GF) mice that were randomized to receive either regular HFD or HFD containing mung bean protein isolate (MPI) instead of the dairy protein present in regular HFD...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29777493/transgenic-mice-carrying-glud2-as-a-tool-for-studying-the-expressional-and-the-functional-adaptation-of-this-positive-selected-gene-in-human-brain-evolution
#4
Andreas Plaitakis, Dimitra Kotzamani, Zoe Petraki, Maria Delidaki, Vagelis Rinotas, Ioannis Zaganas, Eleni Douni, Kyriaki Sidiropoulou, Cleanthe Spanaki
Human evolution is characterized by brain expansion and up-regulation of genes involved in energy metabolism and synaptic transmission, including the glutamate signaling pathway. Glutamate is the excitatory transmitter of neural circuits sub-serving cognitive functions, with glutamate-modulation of synaptic plasticity being central to learning and memory. GLUD2 is a novel positively-selected human gene involved in glutamatergic transmission and energy metabolism that underwent rapid evolutionary adaptation concomitantly with prefrontal cortex enlargement...
May 18, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29777468/van-wyk-grumbach-syndrome-a-rare-consequence-of-hypothyroidism
#5
Pavan Reddy, Kritika Tiwari, Abhishek Kulkarni, Ketan Parikh, Raju Khubchandani
Long standing hypothyroidism presenting as an ovarian mass has been well described in literature as the Van Wyk Grumbach syndrome (hypothyroidism, isosexual precocious puberty and ovarian mass). Here, authors report this entity in a 11 y 7 mo old girl child who was referred to a surgeon in view of intestinal obstruction along with a multiloculated ovarian cyst. On evaluation, she was found to have raised serum creatinine, short stature, delayed bone age and pituitary enlargement. She was diagnosed with autoimmune thyroiditis and was started on replacement therapy with thyroxine, after which the ovarian cysts regressed...
May 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29777364/cell-division-and-turgor-mediate-enhanced-plant-growth-in-arabidopsis-plants-treated-with-the-bacterial-signalling-molecule-lumichrome
#6
Motlalepula Pholo, Beatrix Coetzee, Hans J Maree, Philip R Young, James R Lloyd, Jens Kossmann, Paul N Hills
Transcriptomic analysis indicates that the bacterial signalling molecule lumichrome enhances plant growth through a combination of enhanced cell division and cell enlargement, and possibly enhances photosynthesis. Lumichrome (7,8 dimethylalloxazine), a novel multitrophic signal molecule produced by Sinorhizobium meliloti bacteria, has previously been shown to elicit growth promotion in different plant species (Phillips et al. in Proc Natl Acad Sci USA 96:12275-12280, https://doi.org/10.1073/pnas.96.22.12275 , 1999)...
May 17, 2018: Planta
https://www.readbyqxmd.com/read/29777140/different-responses-of-left-atrium-and-left-atrial-appendage-to-radiofrequency-catheter-ablation-of-atrial-fibrillation-a-follow-up-mri-study
#7
Yun Gi Kim, Jaemin Shim, Suk-Kyu Oh, Hee-Soon Park, Kwang-No Lee, Sung Ho Hwang, Jong-Il Choi, Young-Hoon Kim
Atrial fibrillation (AF) is known to cause adverse remodeling of left atrium (LA). Radiofrequency catheter ablation (RFCA) of AF is associated with decrease in LA volume. However, the impact of RFCA on left atrial appendage (LAA) volume and hemodynamic function is not fully understood. We analyzed 123 patients who underwent cardiac magnetic resonance imaging (MRI) evaluation before and after RFCA in Korea University Anam Hospital. LA and LAA volume were measured before and after RFCA based on cardiac MRI. Baseline LA volume was 99...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29777134/zebrafish-vcap1x2-regulates-cardiac-contractility-and-proliferation-of-cardiomyocytes-and-epicardial-cells
#8
Fang-Chi Hsieh, Yu-Fen Lu, Ian Liau, Chien-Chang Chen, Chao-Min Cheng, Chung-Der Hsiao, Sheng-Ping L Hwang
Sarcomeric signaling complexes are important to sustain proper sarcomere structure and function, however, the mechanisms underlying these processes are not fully elucidated. In a gene trap experiment, we found that vascular cell adhesion protein 1 isoform X2 (VCAP1X2) mutant embryos displayed a dilated cardiomyopathy phenotype, including reduced cardiac contractility, enlarged ventricular chamber and thinned ventricular compact layer. Cardiomyocyte and epicardial cell proliferation was decreased in the mutant heart ventricle, as was the expression of pAKT and pERK...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776560/large-animal-model-of-acute-right-ventricular-failure-with-functional-tricuspid-regurgitation
#9
Marcin Malinowski, Alistair G Proudfoot, Lenora Eberhart, Hans Schubert, Jeremy Wodarek, David Langholz, Manuel K Rausch, Tomasz A Timek
BACKGROUND: Functional tricuspid regurgitation (FTR) commonly arises secondary to conditions affecting the left heart and is associated with right ventricular dysfunction and tricuspid annular dilatation. We set out to establish an animal model of acute RV failure (RVF) with FTR resembling the clinical features. METHODS: Ten adult sheep had pressure sensors placed in the LV, RV, and right atrium while sonomicrometry crystals were implanted around tricuspid annulus and on the RV...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29776352/surgical-peripheral-iridectomy-via-a-clear-cornea-phacoemulsification-incision-for-pupillary-block-following-cataract-surgery-in-acute-angle-closure
#10
Aiwu Fang, Peijuan Wang, Rui He, Jia Qu
BACKGROUND: To describe a technique of surgical peripheral iridectomy via a clear-cornea tunnel incision to prevent or treat pupillary block following phacoemulsification. METHODS: Description of technique and retrospective description results in 20 eyes of 20 patients with acute angle closure with coexisting visually significant cataract undergoing phacoemulsification considered at risk of postoperative papillary block as well as two pseudo-phakic eyes with acute postoperative pupillary-block...
May 18, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29776107/investigation-of-a-chaotic-thermostat
#11
G J Morales
A numerical study is presented of a free particle interacting with a deterministic thermostat in which the usual friction force is supplemented with a fluctuating force that depends on the self-consistent damping coefficient associated with coupling to the heat bath. It is found that this addition results in a chaotic environment in which a particle self-heats from rest and moves in positive and negative directions, exhibiting a characteristic diffusive behavior. The frequency power spectrum of the dynamical quantities displays the exponential frequency dependence ubiquitous to chaotic dynamics...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775854/a-wavelength-modulated-localized-surface-plasmon-resonance-lspr-optical-fiber-sensor-for-sensitive-detection-of-mercury-ii-ion-by-gold-nanoparticles-dna-conjugates
#12
Shuo Jia, Chao Bian, Jizhou Sun, Jianhua Tong, Shanhong Xia
The study presented herein investigated an easy preparation, high performance, wavelength-modulated LSPR optical fiber chemosensor coated by gold nanospheres(AuNS) for Hg2+ detection based on thymine-Hg2+ -thymine base pair mismatches and the coupled plasmonic resonance effect.Utilizing electrostatic self-assembly method, the high density and dispersivity monolayer AuNS coated LSPR fiber sensor had the near field refractive index sensitivity up to 2016 nm/RIU. The single-strand probe DNA served as a binding element for free AuNS labelled-target DNA conjugates was attached to the monolayer AuNS by Au-S bond...
May 8, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29775480/titan-cells-formation-in-cryptococcus-neoformans-is-finely-tuned-by-environmental-conditions-and-modulated-by-positive-and-negative-genetic-regulators
#13
Benjamin Hommel, Liliane Mukaremera, Radames J B Cordero, Carolina Coelho, Christopher A Desjardins, Aude Sturny-Leclère, Guilhem Janbon, John R Perfect, James A Fraser, Arturo Casadevall, Christina A Cuomo, Françoise Dromer, Kirsten Nielsen, Alexandre Alanio
The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> 10 μm and up to 100 μm). We found and optimized in vitro conditions that produce titan cells in order to identify the ancestry of titan cells, the environmental determinants, and the key gene regulators of titan cell formation. Titan cells generated in vitro harbor the main characteristics of titan cells produced in vivo including their large cell size (>10 μm), polyploidy with a single nucleus, large vacuole, dense capsule, and thick cell wall...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29775477/cryptococcus-neoformans-can-form-titan-like-cells-in-vitro-in-response-to-multiple-signals
#14
Nuria Trevijano-Contador, Haroldo Cesar de Oliveira, Rocío García-Rodas, Suélen Andreia Rossi, Irene Llorente, Ángel Zaballos, Guilhem Janbon, Joaquín Ariño, Óscar Zaragoza
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of the cells during infection. In particular, this process can occur by enlarging the size of the capsule without modifying the size of the cell body, or by increasing the diameter of the cell body, which is normally accompanied by an increase of the capsule too. This last process leads to the formation of cells of an abnormal enlarged size denominated titan cells. Previous works characterized titan cell formation during pulmonary infection but research on this topic has been hampered due to the difficulty to obtain them in vitro...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29775450/-congenital-megacalycosis-in-a-girl-with-unilateral-renal-agenesis
#15
Agnieszka Szmigielska, Grażyna Krzemień, Anna Zacharzewska, Teresa Dudek-Warchoł, Stanisław Warchoł
Renal agenesis occurs in pediatric population with the incidence 1:500- 2000 children. It is more often diagnosed in boys and on the left side of the body. Renal agenesis may be isolated or it may be a part of complex malformation syndrome. Megacalycosis is a very rare anomaly of urinary tract associated with abnormal structure of the kidney pyramids. AIM: The aim of the study was to present for the first time in the medical literature the case of a girl with unilateral renal agenesis and megacalycosis...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29775449/-dodatkowa-t%C3%A4-tnica-nerkowa-przyczyn%C3%A4-skrajnego-wodonercza-u-5-letniego-ch%C3%A5-opca
#16
Grażyna Krzemień, Jarosław Sołtyski, Agnieszka Szmigielska, Stanisław Warchoł, Teresa Dudek-Warchoł, Aleksandra Jakimów-Kostrzewa
Hydronephrosis in children is most often due to an intrinsic ureteropelvic junction obstruction or by compression on ureter by accessory renal artery coming from the aorta to the lower pole of the kidney. AIM: The aim of study was to present a case with a late onset of hydronephrosis caused by accessory renal artery. CASE REPORT: 5-year old boy with a mild pyelectasia during first 10 months of age was admitted to hospital because of abdominal pain and vomiting. Abdominal ultrasound revealed a marked dilatation of the right pelvicalyceal system with renal pelvis measuring 23 mm in anterior-posterior (ap) diameter, enlargement of calyces to 10 mm and narrowed cortex to 5 mm...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29775018/-causes-and-management-of-frontal-sinusitis-after-transfrontal-craniotomy
#17
T C Liu, X F Yu, Z W Gu, W L Bai, Z H Wang, Z W Cao
Objective: The aim of this study is to investigate the causes and the strategy of frontal sinusitis after transfrontal craniotomy by endoscopic frontal sinus surgery and traditional surgery with facial incision. Method: A total of thirty-four patients with frontal sinusitis after transfrontal craniotomy were admitted, with the symptom of purulence stuff, headache and upper eyelid discharging. The onset time was 2.6 years on average. The frontal sinus CT and MRI images showed frontal sinusitis. Twenty-seven patients were treated with endoscopic frontal sinus surgery, and seven patient was treated with combined endoscopic and traditional frontal sinus surgery...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774753/zn-2-loaded-cellulose-beads-stabilized-by-chitosan-and-prepared-via-freeze-drying-for-removing-human-testosterone-in-plasma
#18
Huibin Yu, Hongqin Ke, Tu Chen, Xing Li, Shenglong Tan, Lei Zhou, Shenqi Wang
Hemoperfusion using metal ion affinity adsorbent is a promising method to remove human testosterone in plasma. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion. In this study, chitosan was used to coat the adsorbent for preventing the leakage of Zn2+ loaded. Meanwhile, freeze-drying method was used to enhance adsorption capacity of Zn2+ -loaded cellulose beads for testosterone. The results indicate that after the adsorbent was coated by 0.02% chitosan solution, the highest adsorption percentage reached 48%, during adsorption, the Zn2+ concentration in plasma did not increase; the adsorption capacity of the adsorbent can be significantly enhanced by freeze-drying...
May 18, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29774751/evaluation-of-articular-cartilage-injury-using-computed-tomography-with-axial-traction-in-the-ankle-joint
#19
Tomoyuki Nakasa, Yasunari Ikuta, Mikiya Sawa, Masahiro Yoshikawa, Yusuke Tsuyuguchi, Yuki Ota, Munekazu Kanemitsu, Nobuo Adachi
BACKGROUND: Although chondral or osteochondral injuries are usually assessed by magnetic resonance imaging, its accuracy can be low, presumably related to the relatively thin cartilage layer and the close apposition of the cartilage of the talus and tibial plafond. We hypothesized that axial traction could provide a contrast between the articular cartilage and joint cavity, and it enabled the simultaneous evaluation of cartilage and subchondral bone. The purpose of this study was to assess the feasibility of using computed tomography (CT) imaging with axial traction for the diagnosis of articular cartilage injuries...
May 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29774590/heritage-of-stanislaw-ciechanowski-1869-1945-discoverer-of-pathogenesis-of-prostatic-hyperplasia-passionis-insignia-signis-fulgent-mirificis
#20
Andrzej Wincewicz, Piotr Woltanowski, Stanisław Sulkowski
BACKGROUND: Prostatic enlargement was first correctly recognized as a prostatic hyperplasia by professor of anatomic pathology, Stanisław Ciechanowski (1869-1945) in Cracow on contrary to Parisian urologist Jean Casimir Félix Guyon's concepts of progressing atherosclerosis as a morphological cause of prostatic overgrowth and mechanical insufficiency of lower urinary tract. METHODS: Primary resources were analyzed about Stanisław Ciechanowski mainly from depositories of the Section of Special Collection, Stanisław Konopka Main Medical Library Warsaw and Polish bibliograhy of Estreichers at Jagiellonian University...
May 18, 2018: Prostate
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