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https://www.readbyqxmd.com/read/29216846/reduced-level-of-arousal-and-increased-mortality-in-adult-acute-medical-admissions-a-systematic-review-and-meta-analysis
#1
Amy Todd, Samantha Blackley, Jennifer K Burton, David J Stott, E Wesley Ely, Zoë Tieges, Alasdair M J MacLullich, Susan D Shenkin
BACKGROUND: Reduced level of arousal is commonly observed in medical admissions and may predict in-hospital mortality. Delirium and reduced level of arousal are closely related. We systematically reviewed and conducted a meta-analysis of studies in adult acute medical patients of the relationship between reduced level of arousal on admission and in-hospital mortality. METHODS: We conducted a systematic review (PROSPERO: CRD42016022048), searching MEDLINE and EMBASE...
December 8, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29206286/recognition-of-delirium-features-in-clinical-practice-data-from-the-delirium-day-2015-national-survey
#2
Enrico Mossello, Francesca Tesi, Simona G Di Santo, Andrea Mazzone, Monica Torrini, Antonio Cherubini, Mario Bo, Massimo Musicco, Angelo Bianchetti, Alberto Ferrari, Nicola Ferrara, Marco Trabucchi, Alessandro Morandi, Giuseppe Bellelli
BACKGROUND/OBJECTIVES: Delirium is underrecognized in clinical practice. The primary aim of the present multicenter study was to compare the ability of nurses to identify delirium features with a standardized assessment. The secondary aim was to identify predictors of missed or incorrect identifications of delirium by nurses. DESIGN: Point prevalence study in 120 wards across Italy. SETTING: "Delirium Day 2015." PARTICIPANTS: Inpatients aged 65 and older (N = 1,867)...
December 5, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29199538/the-truth-beneath-the-taste-roses-in-the-urethra-and-first-description-of-neuro-morpho-chemical-mechanism-of-penile-erectil-posture-in-males-an-experimental-study
#3
Mehmet Dumlu Aydın, Nazan Aydın, Ayhan Kanat, Nezih Akca, Gizem Ardic, Coskun Yolas, Konca Altınkaynak, Muhammet Calik
AIMS: The morphologic mechanism of orgasmic sensation has not yet been understood. Taste roseas may be stimulated by fructose via pudendal nerve which has not been studied yet. METHODS: In this study, 27 male adult rabbits were used, and divided into three groups, five as control; five as SHAM and seventeen used as study group. We injected 0.2cc of distilled water to SHAM and 0.2cc of fructose solution to Study Group of their uretralorifices, examined the occurrence of penile erection...
December 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29198512/understanding-the-role-of-serotonin-in-female-hypoactive-sexual-desire-disorder-and-treatment-options
#4
REVIEW
Harry A Croft
BACKGROUND: The neurobiology of sexual response is driven in part by dopamine and serotonin-the former modulating excitatory pathways and the latter regulating inhibitory pathways. Neurobiological underpinnings of hypoactive sexual desire disorder (HSDD) are seemingly related to overactive serotonin activity that results in underactive dopamine activity. As such, pharmacologic agents that decrease serotonin, increase dopamine, or some combination thereof, have therapeutic potential for HSDD...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29198504/female-sexual-dysfunction-medical-and-psychological-treatments-committee-14
#5
Sheryl A Kingsberg, Stanley Althof, James A Simon, Andrea Bradford, Johannes Bitzer, Joana Carvalho, Kathryn E Flynn, Rossella E Nappi, Jennifer B Reese, Roya L Rezaee, Leslie Schover, Jan L Shifrin
INTRODUCTION: Since the millennium we have witnessed significant strides in the science and treatment of female sexual dysfunction (FSD). This forward progress has included (i) the development of new theoretical models to describe healthy and dysfunctional sexual responses in women; (ii) alternative classification strategies of female sexual disorders; (iii) major advances in brain, hormonal, psychological, and interpersonal research focusing on etiologic factors and treatment approaches; (iv) strong and effective public advocacy for FSD; and (v) greater educational awareness of the impact of FSD on the woman and her partner...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29198449/effects-of-flibanserin-on-the-pharmacokinetics-of-a-combined-ethinylestradiol-levonorgestrel-oral-contraceptive-in-healthy-premenopausal-women-a-randomized-crossover-study
#6
Crista Johnson-Agbakwu, Louise Brown, James Yuan, Robert Kissling, David J Greenblatt
PURPOSE: This study aimed to investigate the effect of steady-state exposure to flibanserin, a 5-HT1A agonist/5-HT2A antagonist approved for the treatment of hypoactive sexual desire disorder in premenopausal women, on the single-dose pharmacokinetics of the contraceptive steroids ethinylestradiol and levonorgestrel in healthy premenopausal women. METHODS: Healthy female volunteers (N = 24) received 2 single doses of a combined oral contraceptive containing ethinylestradiol 30 μg and levonorgestrel 150 μg, either alone (reference) or preceded by treatment with flibanserin 100 mg once daily for 14 days (test)...
November 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29197232/uptake-tissue-distribution-and-toxicity-of-polystyrene-nanoparticles-in-developing-zebrafish-danio-rerio
#7
Jordan A Pitt, Jordan S Kozal, Nishad Jayasundara, Andrey Massarsky, Rafael Trevisan, Nick Geitner, Mark Wiesner, Edward D Levin, Richard T Di Giulio
Plastic pollution is a critical environmental concern and comprises the majority of anthropogenic debris in the ocean, including macro, micro, and likely nanoscale (less than 100nm in at least one dimension) plastic particles. While the toxicity of macroplastics and microplastics is relatively well studied, the toxicity of nanoplastics is largely uncharacterized. Here, fluorescent polystyrene nanoparticles (PS NPs) were used to investigate the potential toxicity of nanoplastics in developing zebrafish (Danio rerio), as well as to characterize the uptake and distribution of the particles within embryos and larvae...
November 24, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29197209/cotard-syndrome-in-hypoactive-delirium-a-case-report
#8
Raimund Oberndorfer, Christoph Schönauer, Hans Eichbauer, Klaus Klaushofer, Fabian Friedrich
No abstract text is available yet for this article.
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29185354/validation-and-psychometric-properties-of-the-german-version-of-the-delirium-motor-subtype-scale-dmss
#9
David Garcia Nuñez, Soenke Boettger, Rafael Meyer, André Richter, Maria Schubert, David Meagher, Josef Jenewein
OBJECTIVE: Delirium has been characterized into its subtypes-hypoactive, hyperactive, mixed, or no motor subtype-along with the use of the Delirium Motor Symptom Scale (DMSS). The German version of this scale (DMSS-G), however, has not yet been validated. METHOD: We determined internal consistency, reliability, and validity of the DMSS-G in the surgical intensive care unit, using DSM-IV-TR criteria and the Delirium Rating Scale-Revised-98. RESULTS: In total, 289 patients were included, and out of these, 122 were delirious...
November 1, 2017: Assessment
https://www.readbyqxmd.com/read/29183706/differential-behavioral-phenotypes-of-dopamine-d1-receptor-knockdown-mice-at-the-embryonic-postnatal-and-adult-stages
#10
Tadashi Okubo, Asako Sato, Hirotsugu Okamoto, Toshiya Sato, Toshikuni Sasaoka
Dopamine is widely involved in behaviors related to motor activity, cognition, motivation, and reward. Dopamine signal is transduced through the dopamine receptor gene family. The dopamine D1 receptor (D1R) is highly expressed in the striatum, and is responsible for regulating the motor function. Recently, we have reported that the knockdown (KD) mice in which D1R was conditionally eliminated at adult stage, displayed a hypoactivity in the home cage than wild type mice; however, conventional D1R knockout (KO) mice show hyperactive phenotypes...
November 25, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29177381/-neonatal-meningitis-in-a-general-hospital-in-lima-peru-2008-to-2015
#11
George Lewis, Maggie Schweig, Daniel Guillén-Pinto, María Luz Rospigliosi
Aiming at describing the incidence, clinical characteristics and factors associated with neonatal meningitis (NM), a case series study was conducted from 2008 to 2015, where 53 neonates, 10 with early onset NM and 43 with late onset were included. An incidence of 1.5 per thousand live births and a lethality of 3.8% were found. The associated factors were peripartum fever, urinary tract infection and chorioamnionitis (P < 0.05). Frequent symptoms were fever (84.9%), hypotonia (77.4%) and hypoactivity (73...
April 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29172782/efficacy-of-tribulus-terrestris-for-the-treatment-of-premenopausal-women-with-hypoactive-sexual-desire-disorder-a-randomized-double-blinded-placebo-controlled-trial
#12
Fabiene Bernardes Castro Vale, Karla Zanolla Dias de Souza, Camilla Russi Rezende, Selmo Geber
Although hypoactive sexual desire disorder (HSDD) is the most common sexual complaint, there is no consensus for the ideal treatment. Our study aimed to evaluate the efficacy of treating premenopausal women with HSDD with Tribulus terrestris and its effect on the serum levels of testosterone. We performed a prospective, randomized, double-blind, placebo-controlled trial, with 40 premenopausal women reporting diminished libido, receiving T. terrestris or placebo. The questionnaires FSFI and the QS-F were used to evaluate sexual dysfunction before and after treatment...
November 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29160493/neonatal-appendicitis-a-survival-case-study
#13
Izabela Linha Secco, Taine Costa, Etiene Letícia Leone de Moraes, Márcia Helena de Souza Freire, Mitzy Tannia Reichembach Danski, Regina Paula Guimarães Vieira Cavalcante
OBJECTIVE: To report a case of neonatal appendicitis in a children's hospital in southern Brazil, demonstrating the impact on neonatal survival. METHOD: Case study with data collection from medical records, approved by the Institution and Ethics Committee for Research with Human Beings. RESULTS: The clinical picture is initially characterized by food intolerance, evolving to hypoactivity, alteration of vital signs and septicemia due to intestinal perforation...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29127250/malignant-peripheral-nerve-sheath-tumours-of-the-pericardium-in-a-patient-with-neurofibromatosis-type-1-the-diagnostic-value-of-18f-fdg-pet-ct-and-i-123-mibg-spect-ct
#14
Mathieu Charest, Josephine Pressacco, Jaramie Thomas-Gittens
A 25 year old female with known neurofibromatosis type 1 with a large anterior mediastinal mass was investigated. F18-FDG PET-CT revealed a radiotracer avid anterior mediastinal mass with SUVmax of 4.3 and demonstrating a hypoactive center. The Iodine-123 MIBG SPECT-CT study performed subsequently did not demonstrate any uptake, thereby excluding for the most part the diagnoses of paraganglioma or neuroblastoma. At final pathology, a malignant peripheral nerve sheath tumour (MPNST) of the pericardium with areas of chondrosarcomatous and angiosarcomatous differentiation was diagnosed...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29110954/effect-of-motor-subtypes-of-delirium-in-the-intensive-care-unit-on-fast-track-failure-after-cardiac-surgery
#15
Anna Lee, Jing Lan Mu, Chun Hung Chiu, Tony Gin, Malcolm John Underwood, Gavin Matthew Joynt
OBJECTIVE: The purpose of the study was to evaluate the association between motor subtypes of postoperative delirium in the intensive care unit and fast-track failure (a composite outcome of prolonged stay in the intensive care unit >48 hours, intensive care unit readmission, and 30-day mortality) after cardiac surgery. METHODS: This was a secondary analysis of a prospective cohort study of 600 consecutive adults undergoing cardiac surgery at a university hospital in Hong Kong (July 2013 to July 2015)...
September 30, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29105627/macrophage-related-cytokine-expressions-in-depression-mouse-model-induced-by-chronic-unpredictable-mild-stress
#16
Shoulian Zhu, Lejing Li, Ying Li, Wenyuan Cao
Depression is characterized by mental retardation, interest blank, hypoactivity, anxiety, appetite loss, sexual dysfunction, sleep disorders and other symptoms. The incidence of depressed patients has demonstrated an upward trend in recent years. Antidepressant drugs are commonly used in modern medicine, but they have the side effect of drug resistance. This study aims to explore the effect of acupuncture stimulation on expressions of macrophage-related cytokines in mice with depression induced by chronic unpredictable mild stress (CUMS), and to explore the underlying immunological mechanism...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29095039/women-with-hypoactive-sexual-desire-disorder-versus-sexual-interest-arousal-disorder-an-empirical-test-of-raising-the-bar
#17
Julia I O'Loughlin, Rosemary Basson, Lori A Brotto
In 2013, the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) was published with a major revision to the sexual dysfunction categories, and the diagnosis of female hypoactive sexual desire disorder (HSDD) was replaced with female sexual interest/arousal disorder (SIAD). Since being introduced, concern has been expressed that SIAD inappropriately "raises the bar" for diagnosis. To address these concerns, we sought to evaluate the number of women with a diagnosis of HSDD who also met criteria for SIAD...
November 2, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29094914/testosterone-therapy-review-of-clinical-applications
#18
REVIEW
Ryan C Petering, Nathan A Brooks
Testosterone therapy is increasingly common in the United States, and many of these prescriptions are written by primary care physicians. There is conflicting evidence on the benefit of male testosterone therapy for age-related declines in testosterone. Physicians should not measure testosterone levels unless a patient has signs and symptoms of hypogonadism, such as loss of body hair, sexual dysfunction, hot flashes, or gynecomastia. Depressed mood, fatigue, decreased strength, and a decreased sense of vitality are less specific to male hypogonadism...
October 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29080672/fezf1-is-a-novel-regulator-of-female-sex-behavior-in-mice
#19
Tomaz Büdefeld, Tanja Spanic, Milka Vrecl, Gregor Majdic
Female sexual behavior is a complex process regulated by multiple brain circuits and influenced by sex steroid hormones acting in the brain. Several regions in the hypothalamus have been implicated in the regulation of female sexual behavior although a complete circuitry involved in female sexual behavior is not understood. Fez family zinc finger 1 (Fezf1) gene is a brain specific gene that has been mostly studied in the context of olfactory development, although in a recent study, FEZF1 has been identified as one of the genes responsible for the development of Kallman syndrome...
November 13, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29080551/the-dexamethasone-corticotropin-releasing-hormone-test-in-healthy-and-depressed-women-with-and-without-childhood-adversity
#20
Carsten Spitzer, Christian Otte, Linn K Kuehl, Anita May, Katharina Schultebraucks, Julian Hellmann-Regen, Katja Wingenfeld
BACKGROUND: Alterations of the hypothalamic-pituitary-adrenal (HPA) axis are a prominent finding in patients with major depressive disorder (MDD). Inconsistencies regarding a hyper- or hypoactive HPA axis may be explained by the moderating effect of childhood adverse experiences (ACE) which are associated with both HPA axis dysfunction and MDD in adulthood. We aimed to systematically disentangle the effects of ACE and MDD on HPA axis by comparing healthy women with and without childhood adversity and women with MDD with and without ACE...
October 23, 2017: Psychoneuroendocrinology
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