keyword
https://read.qxmd.com/read/38523173/risk-factors-for-hypoactive-delirium-in-patients-with-nontraumatic-ards-a-prospective-observational-study
#1
JOURNAL ARTICLE
Fuyan Lian, Fei Li, Xuemei Tang, Yuan Yuan
To investigate the incidence, characteristics and risk factors for hypoactive delirium in patients with nontraumatic acute respiratory distress syndrome (ARDS) and to explore the independent risk factors associated with hypoactive delirium and provide new ideas for early prediction and treatment. Hypoactive delirium is a known serious complication in ARDS patients, and currently, there are no effective early detection models or clinical prediction tools, and there is a lack of clinical treatment. This study included nontraumatic ARDS patients who stayed in the intensive care unit (ICU) for more than 24 h and were older than 18 years...
March 24, 2024: Scientific Reports
https://read.qxmd.com/read/38520741/pah-deficient-pathology-in-humanized-c-1066-11g-a-phenylketonuria-mice
#2
JOURNAL ARTICLE
Ainhoa Martínez-Pizarro, Sara Picó, Arístides López-Márquez, Claudia Rodriguez-López, Elena Montalvo, Mar Alvarez, Margarita Castro, Santiago Ramón-Maiques, Belén Pérez, José J Lucas, Eva Richard, Lourdes R Desviat
We have generated using CRISPR/Cas9 technology a partially humanized mouse model of the neurometabolic disease phenylketonuria (PKU), carrying the highly prevalent PAH variant c.1066-11G>A. This variant creates an alternative 3' splice site, leading to the inclusion of 9 nucleotides coding for 3 extra amino acids between Q355 and Y356 of the protein. Homozygous Pah c.1066-11A mice, with a partially humanized intron 10 sequence with the variant, accurately recapitulate the splicing defect and present almost undetectable hepatic PAH activity...
March 23, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38509077/mettl3-dependent-m-6-a-modification-of-psen1-mrna-regulates-craniofacial-development-through-the-wnt-%C3%AE-catenin-signaling-pathway
#3
JOURNAL ARTICLE
Lan Ma, Xi Zhou, Siyue Yao, Xinyu Zhang, Ji Mao, Barbara Vona, Liwen Fan, Shu Lou, Dandan Li, Lin Wang, Yongchu Pan
Craniofacial malformations, often associated with syndromes, are prevalent birth defects. Emerging evidence underscores the importance of m6 A modifications in various bioprocesses such as stem cell differentiation, tissue development, and tumorigenesis. Here, in vivo, experiments with zebrafish models revealed that mettl3-knockdown embryos at 144 h postfertilization exhibited aberrant craniofacial features, including altered mouth opening, jaw dimensions, ethmoid plate, tooth formation and hypoactive behavior...
March 20, 2024: Cell Death & Disease
https://read.qxmd.com/read/38502682/computational-insights-into-dynamics-and-conformational-stability-of-n-acetylmannosamine-kinase-mutations
#4
JOURNAL ARTICLE
Ashraf B Abdel-Naim, Pawan Kumar, Mohammed A Bazuhair, Waleed Y Rizg, Hatoon A Niyazi, Khalil Alkuwaity, Hanouf A Niyazi, Saif A Alharthy, Steve Harakeh, Shafiul Haque, Amresh Prakash, Vijay Kumar
The activity of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) is essential for the biosynthesis of sialic acid, which is involved in cellular processes in health and diseases. GNE contains an N-terminal epimerase domain and a C-terminal kinase domain (N-acetylmannosamine kinase, MNK). Mutations of the GNE protein led to hypoactivity of the enzyme and cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy. Here, we used all-atom molecular dynamics (MD) simulations to comprehend the folding, dynamics and conformational stability of MNK variants, including the wild type (WT) and three mutants (H677R, V696M and H677R/V696M)...
March 19, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38484496/functional-neuroimaging-in-patients-with-catatonia-a-systematic-review
#5
REVIEW
Laura Duque, Mohammad Ghafouri, Nicolas A Nunez, Juan Pablo Ospina, Kemuel L Philbrick, John D Port, Rodolfo Savica, Larry J Prokop, Teresa A Rummans, Balwinder Singh
BACKGROUND: Catatonia is a challenging and heterogeneous neuropsychiatric syndrome of motor, affective and behavioral dysregulation which has been associated with multiple disorders such as structural brain lesions, systemic diseases, and psychiatric disorders. This systematic review summarized and compared functional neuroimaging abnormalities in catatonia associated with psychiatric and medical conditions. METHODS: Using PRISMA methods, we completed a systematic review of 6 databases from inception to February 7th, 2024 of patients with catatonia that had functional neuroimaging performed...
March 11, 2024: Journal of Psychosomatic Research
https://read.qxmd.com/read/38482856/management-of-hypoactive-sexual-desire-dysfunction-at-a-specialized-service-in-women-s-sexual-health
#6
JOURNAL ARTICLE
Bruna Holanda Luz do Nascimento, Juliana Ribeiro Figueira, Ana Carolina Japur de Sá Rosa-E-Silva, Rosana Maria Reis, Maíra Cristina Ribeiro Andrade, Luiz Gustavo Oliveira Brito, Lucia Alves da Silva Lara
Hypoactive sexual desire dysfunction (HSDD) is prevalent among women. This retrospective cohort study aimed to verify the results of the strategies used by Gynecologists and Obstetricians (Ob-gyn) residents in the management of female HSDD. For this, we conducted a data collection of patient medical records of women with HSDD from the Human Sexuality Studies outpatient clinic of the Human Reproduction Center, Department of Gynecology and Obstetrics of FMRP-USP, from 2005 to 2019. Among the 437 women included, 361 (82...
March 14, 2024: Journal of Sex & Marital Therapy
https://read.qxmd.com/read/38476659/modeling-sporadic-alzheimer-s-disease-in-mice-by-combining-apolipoprotein-e4-risk-gene-with-environmental-risk-factors
#7
JOURNAL ARTICLE
Kiruthika Ganesan, Peggy Rentsch, Alexander Langdon, Luke T Milham, Bryce Vissel
INTRODUCTION: Developing effective treatment for Alzheimer's disease (AD) remains a challenge. This can be partially attributed to the fact that the mouse models used in preclinical research largely replicate familial form of AD, while majority of human cases are sporadic; both forms differ widely in the onset and origin of pathology, therefore requiring specific/targeted treatments. METHODS: In this study, we aimed to model sporadic AD in mice by combining two of the many risk factors that are strongly implicated in AD: ApoE4, a major genetic risk factor, together with an inflammatory stimuli...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38466020/spontaneous-retropharyngeal-abscess-presenting-as-delirium-in-a-frail-older-woman
#8
JOURNAL ARTICLE
Melisa Mehmed, Ben Walters, Heather Keys, Pann Ei Hnynn Si, Nandkishor Athavale, Ahmed H Abdelhafiz
INTRODUCTION: Retropharyngeal abscess (RPA) is an uncommon infection in older people, which usually presents with localized upper airway symptoms. CASE PRESENTATION: We present a case of RPA in a 69-year-old frail woman with co-morbidities, who presented atypically with delirium. She initially complained of general symptoms of malaise, body aches and general decline. Her symptoms progressed to hypoactive delirium before she started to localize her complaints to the upper airway...
March 11, 2024: Hospital Practice (Minneapolis)
https://read.qxmd.com/read/38464275/brain-substates-induced-by-dmt-relate-to-sympathetic-output-and-meaningfulness-of-the-experience
#9
Lorenzo Pasquini, Alexander Simon, Courtney Gallen, Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart-Harris, Christopher Timmermann
N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory distortions and visual imagery. Multimodal neuroimaging data paired with dynamic analysis techniques offer a valuable approach for identifying unique signatures of brain activity - and linked autonomic physiology - naturally unfolding during the altered state of consciousness induced by DMT...
February 19, 2024: bioRxiv
https://read.qxmd.com/read/38456229/perioperative-knowledge-self-efficacy-and-clinical-practices-related-to-postoperative-delirium-care-in-older-people-across-geographical-regions-in-australia
#10
JOURNAL ARTICLE
Ezinne O Igwe, Jessica Nealon, Pauline O'Shaughnessy, Callum Ormonde, Victoria Traynor
INTRODUCTION: In older people undergoing surgery, there is a lower tolerance for complications. This highlights the need for documented clinical practices on proper prevention, pre-screening and management of complications such as postoperative delirium (POD). Evidence-based clinical practice guidelines exist for delirium management; however, the management of delirium in clinical settings differs widely. OBJECTIVE: This study aims to develop an understanding of the knowledge, components of self-efficacy (confidence/competence), and clinical practice related to POD care among preoperative and recovery nurses across different types of geographical locations in Australia...
March 8, 2024: Australian Journal of Rural Health
https://read.qxmd.com/read/38454963/impaired-cognitive-flexibility-and-disrupted-cognitive-cerebellum-in-degenerative-cerebellar-ataxias
#11
JOURNAL ARTICLE
Jung Hwan Shin, Heejung Kim, So Yeon Lee, Won Tae Yoon, Sun-Won Park, Sangmin Park, Dallah Yoo, Jee-Young Lee
There is a clinically unmet need for a neuropsychological tool that reflects the pathophysiology of cognitive dysfunction in cerebellar degeneration. We investigated cognitive flexibility in degenerative cerebellar ataxia patients and aim to identify the pathophysiological correlates of cognitive dysfunction in relation to cerebellar cognitive circuits. We prospectively enrolled degenerative cerebellar ataxia patients with age-matched healthy controls who underwent 3 T 3D and resting-state functional MRI...
2024: Brain communications
https://read.qxmd.com/read/38454759/does-stress-response-axis-activation-differ-between-patients-with-autoimmune-disease-and-healthy-people
#12
JOURNAL ARTICLE
Eva Montero-López, María Isabel Peralta-Ramírez, Norberto Ortego-Centeno, José Mario Sabio, José Luis Callejas-Rubio, Nuria Navarrete-Navarrete, M Carmen García-Ríos, Ana Santos-Ruiz
Many studies have shown that patients with autoimmune disease present a hypoactive hypothalamic-pituitary-adrenal (HPA) axis, but the results are controversial. Our objective was to study differences in stress response axis activity between patients with autoimmune disease and healthy people. The study sample consisted of 97 women divided into four groups: 37 healthy women (HW), 21 with systemic lupus erythematosus (SLE), 21 with Sjögren's syndrome (SS), and 18 with systemic sclerosis (SSc). After being exposed to a stress task, participants' skin conductance and salivary cortisol levels were measured in order to assess their response to psychological stress...
March 7, 2024: Stress and Health: Journal of the International Society for the Investigation of Stress
https://read.qxmd.com/read/38442192/microscopic-focus-on-the-thyroid-follicles-of-the-one-humped-camel-camelus-dromedarius
#13
JOURNAL ARTICLE
Karam Roshdy, Mohamed A M Alsafy, Samir A A El-Gendy, Ahmed A El-Mansi, Shaymaa Rezk
The microstructure of the thyroid gland of the one-humped camel (Camelus dromedarius) was described using morphometric, histological, immunohistochemical staining, and ultrastructural standard techniques. The follicular secretory units of the thyroid glands displayed comparable and variable sizes where the large follicles were situated at the peripheral margins; however, the small ones were located in the central region. Semisquamous epithelium (low cuboidal) lined the large thyroid follicles, while high cuboidal (columnar) epithelium lined the small ones...
March 5, 2024: Microscopy and Microanalysis
https://read.qxmd.com/read/38441523/commentary-on-characteristics-of-systemic-testosterone-therapy-for-female-hypoactive-sexual-desire-disorder-a-claims-database-analysis
#14
JOURNAL ARTICLE
Javier Angulo
No abstract text is available yet for this article.
March 5, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38441520/characteristics-of-systemic-testosterone-therapy-for-female-hypoactive-sexual-desire-disorder-a-claims-database-analysis
#15
JOURNAL ARTICLE
Pranjal Agrawal, Yeonsoo Sara Lee, Aurora J Grutman, Kathryn Dumas, Taylor Kohn, Jaden Kohn, Alyssa M Yee, Marisa Clifton
BACKGROUND: Testosterone therapy (TTh) is recommended for postmenopausal women with hypoactive sexual desire disorder (HSDD); however, there remain insufficient data to support use of TTh in premenopausal women with sexual dysfunction. AIM: In this study, we used a large national database to evaluate prescribing trends of TTh for women with HSDD. METHODS: We conducted a cohort analysis of information from electronic health records acquired from the data network TriNetX Diamond...
March 5, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38433895/homozygous-als-linked-mutations-in-tardbp-tdp-43-lead-to-hypoactivity-and-synaptic-abnormalities-in-human-ipsc-derived-motor-neurons
#16
JOURNAL ARTICLE
Sarah Lépine, Angela Nauleau-Javaudin, Eric Deneault, Carol X-Q Chen, Narges Abdian, Anna Krystina Franco-Flores, Ghazal Haghi, María José Castellanos-Montiel, Gilles Maussion, Mathilde Chaineau, Thomas Martin Durcan
Cytoplasmic mislocalization and aggregation of the RNA-binding protein TDP-43 is a pathological hallmark of the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS). Furthermore, while mutations in TARDBP (encoding TDP-43) have been associated with ALS, the pathogenic consequences of these mutations remain poorly understood. Using CRISPR-Cas9, we engineered two homozygous knock-in induced pluripotent stem cell lines carrying mutations in TARDBP encoding TDP-43A382T and TDP-43G348C , two common yet understudied ALS TDP-43 variants...
March 15, 2024: IScience
https://read.qxmd.com/read/38425845/understanding-the-cognitive-and-neuroimaging-bases-underlying-the-detrimental-impact-of-sleep-deprivation-on-reciprocity
#17
JOURNAL ARTICLE
Wenwen Yu, Jie Chen, Zhifei Kong, Wei Sun, Xiaolin Zhou, Lin Lu, Xiaoxue Gao, Hongqiang Sun
Although the impact of sleep loss on social behaviors has been widely observed in recent years, the mechanisms underpinning these impacts remain unclear. In this study, we explored the detrimental effects of sleep deprivation on reciprocity behavior as well as its underlying psychological and neuroimaging mechanisms by combining sleep manipulation, an interpersonal interactive game, computational modeling and neuroimaging. Our results suggested that after sleep deprivation, individuals showed reduced reciprocity behavior, mainly due to their reduced weights on communal concern when making social decisions...
March 15, 2024: IScience
https://read.qxmd.com/read/38407137/personality-traits-in-relation-to-cognitive-disengagement-syndrome-and-adhd-inattention-in-two-samples-of-children
#18
JOURNAL ARTICLE
Joseph W Fredrick, Stephen P Becker
OBJECTIVE: Cognitive disengagement syndrome (CDS; previously referred to as sluggish cognitive tempo) is a set of behaviors, including excessive mind-wandering, mental fogginess, and hypoactivity, that are separate from ADHD inattentive (ADHD-IN) symptoms and linked to functional outcomes. However, CDS and ADHD-IN symptoms are strongly associated, and our understanding of whether personality correlates are similarly or differentially linked to CDS and ADHD-IN is limited. The objective of the current study was to examine personality correlates of CDS and ADHD-IN symptoms across two independent samples of school-aged youth...
February 26, 2024: Journal of Clinical Child and Adolescent Psychology
https://read.qxmd.com/read/38394938/waugh-syndrome-a-rare-coexistence-of-intussusception-and-intestinal-malrotation-case-report-and-literature-review
#19
Malvina Asbah, Oadi N Shrateh, Hadeel Ashqar, Asil Musleh, Khaled Abbadi, Wael Amro
INTRODUCTION: Waugh's syndrome, characterized by the concurrent presence of acute intussusception and gut malrotation, is a rare clinical entity. The relationship between these conditions is not well-explored, and the true incidence may be underreported. CASE PRESENTATION: A 4 month old male infant, with an uneventful medical history, presented to the pediatric emergency department due to irritability and rectal bleeding lasting one day. The infant had a history of bilious vomiting and dark bloody rectal discharge...
February 20, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38382145/retroperitoneal-necrotizing-fasciitis-mimicking-perforated-appendicitis-a-case-report
#20
Negassa Getachew Tarekegn, Tadesse Girma Moges, Feyera Abetu Guluju
INTRODUCTION: Necrotizing fasciitis (NF) is a rare and rapidly progressing soft tissue infection. The commonly involved body parts are the extremities and trunk. Necrotizing fasciitis (NF) involving the retroperitoneum is very uncommon but associated with higher morbidity and mortality. There are only a few patients survived according to the report. PRESENTATION OF CASE: This is a 19-year-old male patient presented with abdominal pain, high-grade fever, vomiting and abdominal distension for 3 days...
February 20, 2024: International Journal of Surgery Case Reports
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