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https://www.readbyqxmd.com/read/29678474/the-impact-of-body-awareness-on-women-s-sexual-health-a-comprehensive-review
#1
REVIEW
Brooke N Seal, Cindy M Meston
INTRODUCTION: Body awareness has been linked to female sexual response in laboratory manipulation studies and is used in clinical settings to ameliorate sexual difficulties. AIM: To evaluate and review the literature on body awareness and female sexual function. METHODS: A literature review was conducted through PsycInfo, PsycARTICLES, and PubMed using terms such as body awareness and sexual function. A manual search also was conducted using reference lists...
April 17, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29676052/rapamycin-protects-against-early-brain-injury-independent-of-cerebral-blood-flow-changes-in-a-mouse-model-of-subarachnoid-haemorrhage
#2
Kazumasu Sasaki, Shuzo Yamamoto, Tatsushi Mutoh, Yoshiharu Tsuru, Yasuyuki Taki, Ryuta Kawashima
We evaluated the neuroprotective role of rapamycin, a mammalian target of rapamycin (mTOR) kinase inhibitor, in cerebral ischaemia and locomotor function in a mouse model of subarachnoid haemorrhage (SAH). Pretreatment with rapamycin, a mTOR kinase inhibitor, resulted in better recovery from cerebral hypoxia early after SAH than control (P < .05), while the values of peak flow velocity in the middle cerebral artery did not change significantly (P > .05). The ratio of central-area distance/total travelled distance determined by open-field test after day 14 was significantly higher in mice pretreated with rapamycin than in control mice (P < ...
April 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29668850/altered-neocortical-gene-expression-brain-overgrowth-and-functional-over-connectivity-in-chd8-haploinsufficient-mice
#3
Philipp Suetterlin, Shaun Hurley, Conor Mohan, Kimberley L H Riegman, Marco Pagani, Angela Caruso, Jacob Ellegood, Alberto Galbusera, Ivan Crespo-Enriquez, Caterina Michetti, Yohan Yee, Robert Ellingford, Olivier Brock, Alessio Delogu, Philippa Francis-West, Jason P Lerch, Maria Luisa Scattoni, Alessandro Gozzi, Cathy Fernandes, M Albert Basson
Truncating CHD8 mutations are amongst the highest confidence risk factors for autism spectrum disorder (ASD) identified to date. Here, we report that Chd8 heterozygous mice display increased brain size, motor delay, hypertelorism, pronounced hypoactivity, and anomalous responses to social stimuli. Whereas gene expression in the neocortex is only mildly affected at midgestation, over 600 genes are differentially expressed in the early postnatal neocortex. Genes involved in cell adhesion and axon guidance are particularly prominent amongst the downregulated transcripts...
April 13, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29667849/defensive-coping-facilitated-a-smaller-cortisol-to-estradiol-ratio-and-a-higher-hypertension-risk-the-sabpa-study
#4
Leoné Malan, Andrea de Kock, Mark Hamer, Marike Cockeran, Nicolaas Theodor Malan
OBJECTIVES: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It can however also induce α1 -adrenergic vasoconstrictive responsiveness. We aimed to determine whether the cortisol-to-estradiol ratio (Cort:E2) may augment α1 -adrenergic responsiveness and hypertension risk when habitually using defensive coping. METHODS: African (n = 168) and Caucasian (n = 207) men and women (46 ± 9 years) were included...
April 18, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29608877/the-role-of-adhd-associated-genes-in-neurodevelopment
#5
REVIEW
Callum Dark, Jihane Homman-Ludiye, Robert J Bryson-Richardson
Attention deficit hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder of childhood. It is primarily characterised by high levels of activity, inattention, and impulsivity, and has strong negative impacts on academic functioning. Children with ADHD show a reduction in volume, and hypoactivity, in a range of brain regions. The underlying mechanisms behind these phenotypes are unknown, however, variants in several genes with known roles in neurodevelopment are associated with ADHD. In this review we discuss how these ADHD associated genes contribute to neurodevelopment, and how variants in these genes could give rise to the neurological phenotypes seen in ADHD...
March 30, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29599416/low-protein-diet-in-puberty-impairs-testosterone-output-and-energy-metabolism-in-male-rats
#6
Júlio Cezar de Oliveira, Egberto G Moura, Rosiane Aparecida Miranda, Ana Moraes, Luiz Felipe Barella, Ellen Paula Santos da Conceição, Rodrigo Mello Gomes, Tatiane Aparecida da Silva Ribeiro, Ananda Malta, Isabela Peixoto Martins, Claudinéia Conationi da Silva Franco, Patricia Lisboa, Paulo Cezar de Freitas Mathias
We examined the long-term effects of protein restriction during puberty on the function of hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes in male rats. Male Wistar rats were fed a low-protein diet (4%, LP) from 30 to 60 days-old. A normal-protein diet (20.5%) was reintroduced from 60 to 120 days-old. Control rats were fed a normal-protein diet throughout life (NP). Rats were euthanized at 60 or 120 days-old. Food consumption, body weight, visceral fat deposits, lipid profile, glycemia, insulinemia, corticosteronemia, adrenocorticotropic hormone (ACTH), testosteronemia and leptinemia were evaluated...
March 29, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29595541/co-administration-of-amphetamine-with-alcohol-results-in-decreased-alcohol-withdrawal-severity-in-adolescent-rats
#7
Shayna Popkin, Alex Nanchanatt, Madelyn I Mauterer, Dennis E Rhoads
Simultaneous use of stimulants and alcohol is a growing problem, particularly among older adolescents already prone to binge alcohol consumption. Adolescent rats consume high levels of alcohol when administered in a liquid diet and develop a strong alcohol withdrawal syndrome. We exploited this system to administer amphetamine in combination with alcohol and to test the effect of co-administration of amphetamine on alcohol withdrawal-induced hypoactivity and overall withdrawal severity. The presence of dietary amphetamine (≤40 mg/l) had no effect on consumption of control or alcohol-containing diets...
March 27, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29594872/calcium-calmodulin-stimulated-adenylyl-cyclases-1-and-8-regulate-reward-related-brain-activity-and-ethanol-consumption
#8
Kelly E Bosse, Farhad Ghoddoussi, Ajay T Eapen, Jennifer L Charlton, Laura L Susick, Kirt Desai, Bruce A Berkowitz, Shane A Perrine, Alana C Conti
Evidence suggests a predictive link between elevated basal activity within reward-related networks (e.g., cortico-basal ganglia-thalamic networks) and vulnerability for alcoholism. Both calcium channel function and cyclic adenosine monophosphate (cAMP)/protein kinase A-mediated signaling are critical modulators of reward neurocircuitry and reward-related behaviors. Calcium/calmodulin-stimulated adenylyl cyclases (AC) 1 and 8 are sensitive to activity-dependent increases in intracellular calcium and catalyze cAMP production...
March 28, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29576442/effect-size-in-efficacy-trials-of-women-with-decreased-sexual-desire
#9
REVIEW
Robert E Pyke, Anita H Clayton
BACKGROUND: Regarding hypoactive sexual desire disorder (HSDD) in women, some reviewers judge the effect size small for medications vs placebo, but substantial for cognitive behavior therapy (CBT) or mindfulness meditation training (MMT) vs wait list. However, we lack comparisons of the effect sizes for the active intervention itself, for the control treatment, and for the differential between the two. AIM: For efficacy trials of HSDD in women, compare effect sizes for medications (testosterone/testosterone transdermal system, flibanserin, and bremelanotide) and placebo vs effect sizes for psychotherapy and wait-list control...
March 22, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29571872/alterations-of-regional-homogeneity-in-freezing-of-gait-in-parkinson-s-disease
#10
Caihong Zhou, Xiaoling Zhong, Yongzhe Yang, Wanqun Yang, Lijuan Wang, Yuhu Zhang, Kun Nie, Jianmin Xu, Biao Huang
INTRODUCTION: Freezing of gait (FOG) is a serious complication in patients with Parkinson's disease (PD), and is more common in the late state of the disease. The high risk of falling in patients with FOG impacts their quality of life. OBJECTIVE: To explore altered neuroactivity related to cognitive and executive function of PD patients with FOG. METHODS: Fourteen PD patients with FOG (FOG+), 20 PD patients without FOG (FOG-), and 18 normal controls (NC) were enrolled...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29570769/low-hair-cortisol-concentration-and-emerging-attention-deficit-hyperactivity-symptoms-in-preschool-age
#11
Susan Schloß, Isabelle Ruhl, Viola Müller, Katja Becker, Nadine Skoluda, Urs M Nater, Ursula Pauli-Pott
Previous research demonstrated hypoactivity of the HPA axis in children with attention-deficit/hyperactivity disorder (ADHD) or externalizing symptoms. We analyzed the predictive association between the long-term HPA axis activity and increasing symptoms of ADHD in the preschool period. The sample consisted of n = 125 4-year-old children and their families (including n = 64 children with elevated ADHD symptoms). ADHD symptoms were assessed by a structured clinical interview with the mother and by parent- and teacher-report questionnaires...
March 23, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29560257/homeostatic-synaptic-scaling-molecular-regulators-of-synaptic-ampa-type-glutamate-receptors
#12
REVIEW
Dhrubajyoti Chowdhury, Johannes W Hell
The ability of neurons and circuits to maintain their excitability and activity levels within the appropriate dynamic range by homeostatic mechanisms is fundamental for brain function. Neuronal hyperactivity, for instance, could cause seizures.  One such homeostatic process is synaptic scaling, also known as synaptic homeostasis. It involves a negative feedback process by which neurons adjust (scale) their postsynaptic strength over their whole synapse population to compensate for increased or decreased overall input thereby preventing neuronal hyper- or hypoactivity that could otherwise result in neuronal network dysfunction...
2018: F1000Research
https://www.readbyqxmd.com/read/29545008/the-international-society-for-the-study-of-women-s-sexual-health-process-of-care-for-management-of-hypoactive-sexual-desire-disorder-in-women
#13
REVIEW
Anita H Clayton, Irwin Goldstein, Noel N Kim, Stanley E Althof, Stephanie S Faubion, Brooke M Faught, Sharon J Parish, James A Simon, Linda Vignozzi, Kristin Christiansen, Susan R Davis, Murray A Freedman, Sheryl A Kingsberg, Paraskevi-Sofia Kirana, Lisa Larkin, Marita McCabe, Richard Sadovsky
The International Society for the Study of Women's Sexual Health process of care (POC) for management of hypoactive sexual desire disorder (HSDD) algorithm was developed to provide evidence-based guidelines for diagnosis and treatment of HSDD in women by health care professionals. Affecting 10% of adult females, HSDD is associated with negative emotional and psychological states and medical conditions including depression. The algorithm was developed using a modified Delphi method to reach consensus among the 17 international panelists representing multiple disciplines...
March 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29545004/managing-the-hypoactive-sexual-desire-disorder-in-women
#14
EDITORIAL
Vesna D Garovic, Amy Williams, Karl A Nath
No abstract text is available yet for this article.
March 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29532805/sexual-dysfunction-and-male-infertility
#15
REVIEW
Francesco Lotti, Mario Maggi
Infertility affects up to 12% of all men, and sexual dysfunction occurs frequently in men of reproductive age, causing infertility in some instances. In infertile men, hypoactive sexual desire and lack of sexual satisfaction are the most prevalent types of sexual dysfunction, ranging from 8.9% to 68.7%. Erectile dysfunction and/or premature ejaculation, evaluated with validated tools, have a prevalence of one in six infertile men, and orgasmic dysfunction has a prevalence of one in ten infertile men. In addition, infertile men can experience a heavy psychological burden...
March 13, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29530328/clinical-characteristics-prevalence-and-factors-related-to-delirium-in-children-of-5-to-14-years-of-age-admitted-to-intensive-care
#16
C Ricardo Ramirez, M L Álvarez Gómez, C A Agudelo Vélez, S Zuluaga Penagos, R A Consuegra Peña, K Uribe Hernández, I C Mejía Gil, E M Cano Londoño, M Elorza Parra, J G Franco Vásquez
OBJECTIVE: To evaluate the clinical characteristics, prevalence and factors associated with delirium in critical patients from 5 to 14 years of age. DESIGN: An analytical, cross-sectional observational study was made. Delirium was assessed with the Pediatric-Confusion Assessment Method for the Intensive Care Unit (pCAM-ICU) and motor classification was established with the Delirium Rating Scale Revised-98. SETTING: A pediatric Intensive Care Unit...
March 9, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29523489/male-sexual-quality-of-life-is-maintained-satisfactorily-throughout-life-in-the-amazon-rainforest
#17
Thiago Teixeira, Maira Nazima, Jorge Hallak
INTRODUCTION: The Amazon Rainforest is a cradle of biodiversity, where different ethnic groups have specific sexual habits. AIMS: To define the average sexual quality of life of Amazonian men 18 to 69 years old, evaluate the influence of aging on their sexual function, and calculate the prevalence of premature ejaculation, delayed ejaculation, and hypoactive sexual desire disorder. METHODS: A cross-sectional quantitative probability sample study was performed with a demographically representative population (N = 385), with data collected privately at participants' houses, including men who had been sexually active for a minimum of 6 months...
March 6, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29523488/evaluation-and-management-of-hypoactive-sexual-desire-disorder
#18
REVIEW
Anita H Clayton, Sheryl A Kingsberg, Irwin Goldstein
INTRODUCTION: Hypoactive sexual desire disorder (HSDD) often has a negative impact on the health and quality of life of women; however, many women do not mention-let alone discuss-this issue with their physicians. Providers of gynecologic services have the opportunity to address this subject with their patients. AIM: To review the diagnosis and evidence-based treatment of low sexual desire in women with a focus on strategies that can be used efficiently and effectively in the clinic...
March 6, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29522544/sex-differences-in-the-association-between-internalizing-symptoms-and-hair-cortisol-level-among-10-12-year-old-adolescents-in-china
#19
Qingyun Lu, Fada Pan, Lingling Ren, Jing Xiao, Fangbiao Tao
Although numerous studies have described the relationship between HPA axis dysregulation and internalizing symptoms among adolescents, research using hair cortisol concentrations in pre- and young adolescent samples has not been reported. We investigated the association of self-reported internalizing symptoms with cortisol concertration in hair among pre- and young adolescents aged 10-12 years. Forty-six boys and 39 girls supplied a hair sample of at least 3 cm in length for an analysis of this period (3 months) cortisol excretion...
2018: PloS One
https://www.readbyqxmd.com/read/29518359/functional-imbalance-of-anterolateral-entorhinal-cortex-and-hippocampal-dentate-ca3-underlies-age-related-object-pattern-separation-deficits
#20
Zachariah M Reagh, Jessica A Noche, Nicholas J Tustison, Derek Delisle, Elizabeth A Murray, Michael A Yassa
The entorhinal cortex (EC) is among the earliest brain areas to deteriorate in Alzheimer's disease (AD). However, the extent to which functional properties of the EC are altered in the aging brain, even in the absence of clinical symptoms, is not understood. Recent human fMRI studies have identified a functional dissociation within the EC, similar to what is found in rodents. Here, we used high-resolution fMRI to identify a specific hypoactivity in the anterolateral EC (alEC) commensurate with major behavioral deficits on an object pattern separation task in asymptomatic older adults...
March 7, 2018: Neuron
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