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https://www.readbyqxmd.com/read/28535635/-evaluation-of-ct-guided-iodine-125-seeds-brachytherapy-for-intracranial-malignant-tumors-under-control-of-target-and-dose
#1
X K Hu, L J Peng, S F Liu, K X Zhang, Y S Liu, F J Zhang, X D Zhu, X Z Gong, Y Gao, D F Wang, Z X Tina, Zixiang Li
Objective: To assess the efficacy and safety of CT-guided iodine-125 seeds in the treatment of intracranial malignancies under control of target and dose. Methods: From November 2003 to May 2016, with the clinical data of 412 operations on 310 patients in 12 hospitals in the past 14 years, this study analyzed the method of CT guided iodine-125 particles brachytherapy in the treatment of intracranial malignant tumors and evaluated the efficacy and complications. Stratification analysis of intracranial malignant tumors was performed...
May 23, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28534372/serum-expression-level-of-mir-504-can-differentiate-between-glioblastoma-multiforme-and-solitary-brain-metastasis-of-non-small-cell-lung-carcinoma
#2
Zheng Jin, Ri-Hua Jin, Chi Ma, Hai-Song Li, Hai-Yang Xu
PURPOSE: Gliomas are the most common primary intracranial tumors of the central nervous system (CNS), accounting for about one third of all brain tumors. Glioblastoma multiforme (GBM) is the aggressive grade IV glioma with survival as low as 2-5% in the second year post-diagnosis, hence necessitating efficient diagnostic markers. More than 50% of the non-small cell lung cancer (NSCLC) brain metastases are solitary lesions, often difficult to differentiate from gliomas by conventional imaging diagnostics...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28532922/awake-craniotomy-anesthesia-a-comparison-between-the-monitored-anesthesia-care-versus-the-asleep-awake-asleep-technique
#3
Chikezie I Eseonu, Karim ReFaey, Oscar Garcia, Amballur John, Alfredo Quinones-Hinojosa, Punita Tripathi
BACKGROUND: The commonly used sedation techniques for an awake craniotomy includes monitored anesthesia care(MAC), using an unprotected airway, or the asleep-awake-asleep(AAA) technique, using a partially or totally protected airway. We present a comparative analysis between the MAC and AAA technique evaluating anesthetic management, perioperative outcomes, and complications in a consecutive series of patients undergoing the removal of an eloquent brain lesion. METHODS: Eighty-one patients underwent an awake craniotomy for an intracranial lesion over a nine-year period by a single-surgeon and a team of anesthesiologists...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28531342/prognostic-significance-of-preoperative-neutrophilia-on-recurrence-free-survival-in-meningioma
#4
Shirin Karimi, Mana V Vyas, Lior Gonen, Raha Tabasinejad, Quinn Ostrom, Jill Barnholtz-Sloan, Suganth Suppiah, Gelareh Zadeh, Kenneth Aldape
Background: Meningioma is the most common primary intracranial tumor and recurrence is one of the important challenges in patient management. Prognostic factors for tumor recurrences in these patients especially before surgical resection are not fully characterized. Several studies have indicated an association between changes in hematologic laboratory parameters with patient outcomes in solid malignancies. We aimed to assess the association between hematological parameters and tumor recurrence in patients with meningioma...
May 20, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28530316/-radiosurgery-for-pituitary-adenomas
#5
REVIEW
Or Cohen-Inbar
Pituitary adenomas represent one of the most common types of intracranial tumors, accounting for 10-20% of intracranial tumors. While their macroscopic appearance and anatomical location are relatively homogeneous, pituitary tumors differ widely, generating a variety of neurological and endocrine clinical sequelae. Treatment options include hormone suppressive medical therapy, microscopic or endoscopic neurosurgical resection, radiosurgery, radiation therapy, or observation depending on the biochemical profile and the clinical status of the patient...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28528216/prognostic-factors-in-patients-treated-with-surgery-for-brain-metastases-a-single-center-retrospective-analysis-of-125-patients
#6
Zhenghao Liu, Bingxi Lei, Meiguang Zheng, Zhongjun Li, Shuaibin Huang, Yuefei Deng
BACKGROUD: Brain metastases are the most common malignant intracranial tumors,however, the prognosis of patients is still poor despite multiple treatment have been applicated.The aim of this study was to analyse parameters influence overall survival from patient, tumor and treatment. Summarized characteristics of long-time(>2 years) survivors furtherly. MATERIALS AND METHODS: In total, clinical data of 125patients between 2004 and 2015 were collected and the parameters from patients, tumor and treatment were evaluated...
May 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28526958/-ectopic-suprasellar-type-iia-prl-secreting-pituitary-adenoma
#7
REVIEW
Heng-Jun Zhou, De-Sheng Pan, Xiao-Qun Ba, Ren-Ya Zhan, Xiu-Jue Zheng, Yue-Hui Ma
BACKGROUND: Ectopic pituitary adenomas (EPAs) are rare, and the suprasellar cistern seems to be the most common location. At this time, no detailed original classification, diagnosis, or treatment protocols for suprasellar pituitary adenomas (SPAs) have been described. CASE DESCRIPTION: A 19-year-old man showed visual disturbances and lack of libido for 3 years, he suffered a sharp decline in vision with only light perception in the last week. Magnetic resonance imaging scans revealed a large suprasellar cystic lesion with a normal pituitary in the sella turcica...
May 19, 2017: Pituitary
https://www.readbyqxmd.com/read/28526644/simple-tumor-localization-scale-for-estimating-management-outcome-of-intracranial-meningioma
#8
Bruno Splavski, Irina Bagic, Vjenceslav Vrtaric, Brano Splavski
OBJECTIVE: Intracranial meningiomas are typically benign extracerebral tumors derived from dural arachnoid cells. Predominantly, these tumors are effectively managed surgically, but the prognosis is heavily dependent on tumors' histological heterogeneity and its location. It is known that reproductive and hormonal factors increase the risk for meningioma in adult females, but their prognostic value still remains controversial. This study's aim was to examine possible correlation between tumor location and outcome, and to evaluate prognostic value of the proposed simple tumor localization scale in predicting the management outcome of intracranial meningioma...
May 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28523320/multifocal-and-multicentric-low-grade-oligoastrocytoma-in-a-young-patient
#9
Florin Grosu, Aurelian Ungureanu, Elettra Bianchi, Bianca Moscu, Liliana Coldea, Adrian LaurenŢiu Stupariu, Ionica Pirici, Carmen Corina Roman-Filip
Multiple primary central nervous system tumors are rarely seen in clinical practice and reported in the literature. The pathogenesis of multicentricity of primary tumors of the central nervous system still remains a debate, this pathology being found in almost two percent of reported tumor cases. Multifocal tumors are often described within the same hemisphere and supposed to be disseminated along the white matter tracts. On the opposite, multicentric tumors are found in the other hemisphere in subtentorial structures and are considered synchronous...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28521439/arteriovenous-malformation-and-thyroid-metastasis-from-underlying-renal-cell-carcinoma-an-unusual-presentation-of-malignancy-a-case-report
#10
H J Albandar, E S Roberto, J R H See, J H Sabiers
Renal Clear Cell Carcinoma (RCC) comprises over 80% of renal malignancies in adults. Thyroid gland metastasis is rare in RCC. Few studies have described cases of RCC mistaken for benign arteriovenous malformation (AVM). To the best of our knowledge, an AVM arising from underlying RCC metastasis to the brain has not yet been reported. The current study presents a case of RCC metastasis to the thyroid gland, with an AVM identified to be a result of metastatic involvement in the brain. A 45-year-old African-American female presented with left-sided weakness, slurred speech, facial droop and seizure...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521402/imaging-characteristics-and-surgical-treatment-of-invasive-meningioma
#11
Weina Hou, Yongqian Ma, Hongshun Xing, Yuehui Yin
In order to provide an effective way to prevent or substantially delay the recurrence of invasive meningioma, and improve the curative effect of surgical treatment, we collected and analyzed the clinical manifestations, pathological features, preoperative imaging characteristics as well the data obtained during the surgical treatment of invasive meningioma. From February 2014 to February 2016, 59 patients with invasive meningioma were enrolled in this study. Invasive meningioma was confirmed in all patients by operation...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521401/mri-features-of-intracranial-anaplastic-hemangiopericytoma
#12
Liang-Cai Bai, Tian-You Luo, Hao Zhu, Rui Xu
Magnetic resonance imaging (MRI) features of intracranial anaplastic hemangiopericytoma (AHPC) were analyzed. The pathological examination showed that there was a great number of irregularly arranged tumor cells with nuclear atypia, and mitotic properties were commonly seen providing support for clinical staging, therapy and prognosis judgment. Eighteen cases of intracranial AHPC proved by operation and pathology were analyzed retrospectively. Both plain and enhanced MR scans were performed and the results were compared with pathology in all cases...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521349/postoperative-hematoma-requiring-recraniotomy-in-1149-consecutive-patients-with-intracranial-tumors
#13
Teruyoshi Kageji, Shinji Nagahiro, Yoshifumi Mizobuchi, Kohei Nakajima
BACKGROUND: The reported 30-day mortality rate after brain tumor surgery is 2.2% to 2.9%, with a postoperative hematoma (POH) as the most frequent cause of death. OBJECTIVE: To investigate the risk factors for a POH requiring a recraniotomy after brain tumor surgery in a large, contemporary, single-institution consecutive series. METHODS: We included 1149 patients who underwent surgery for intracranial tumors at the Tokushima University Hospital from 1997 to 2014...
June 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28516286/establishment-of-a-tumor-sphere-cell-line-from-a-metastatic-brain-neuroendocrine-tumor
#14
Ryoichi Iwata, Masato Maruyama, Tomoki Ito, Yosuke Nakano, Yonehiro Kanemura, Taro Koike, Souichi Oe, Kunikazu Yoshimura, Masahiro Nonaka, Shosaku Nomura, Tetsuo Sugimoto, Hisao Yamada, Akio Asai
Neuroendocrine tumors are rare, and little is known about the existence of cancer stem cells in this disease. Identification of the tumorigenic population will contribute to the development of effective therapies targeting neuroendocrine tumors. Surgically resected brain metastases from a primary neuroendocrine tumor of unknown origin were dissociated and cultured in serum-free neurosphere medium. Stem cell properties, including self-renewal, differentiation potential, and stem cell marker expression, were examined...
May 17, 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/28513420/optimization-of-glioblastoma-mouse-orthotopic-xenograft-models-for-translational-research
#15
Susan M Irtenkauf, Susan Sobiechowski, Laura A Hasselbach, Kevin K Nelson, Andrea D Transou, Enoch T Carlton, Tom Mikkelsen, Ana C deCarvalho
Glioblastoma is an aggressive primary brain tumor predominantly localized to the cerebral cortex. We developed a panelofpatient-derived mouse orthotopic xenografts (PDOX) for preclinical drug studies by implanting cancer stem cells (CSC) cultured from fresh surgical specimens intracranially into 8-wk-old female athymic nude mice. Here we optimize the glioblastoma PDOX model by assessing the effect of implantation location on tumor growth, survival, and histologic characteristics. To trace the distribution of intracranial injections, toluidine blue dye was injected at 4 locations with defined mediolateral, anterioposterior, and dorsoventral coordinates within the cerebral cortex...
May 16, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28512411/spinal-intradural-intramedullary-dissemination-in-the-absence-of-intracranial-relapse-of-a-previously-radically-treated-temporal-lobe-glioblastoma-multiforme
#16
Lucas Serrano, Eleftherios Archavlis, Elke Januschek, Pavel Timofeev, Peter Ulrich
Intracranial glioblastoma multiforme (GBM) constitutes the most frequent and unfortunately aggressive primary central nervous system malignancy. Despite the high tendency of these tumors to show local relapse within the brain after primary therapy, dissemination into the spinal axis is an infrequent event. If spinal metastases occur they are leptomeningeal in the vast majority of cases and always in the context of intracranial progressive disease. Spinal intramedullary metastases of intracranial GBM have rarely been described to date...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28512049/space-occupying-tumor-bed-cysts-as-a-complication-of-modern-treatment-for-high-grade-glioma
#17
Thomas Beez, Sven Burgula, Marcel Kamp, Marion Rapp, Hans-Jakob Steiger, Michael Sabel
INTRODUCTION: Management of high grade glioma (HGG) was changed by recent landmark trials and is nowadays more proactive. However, aggressive treatment leads to hospitalization due to side effects. Space-occupying tumor bed cysts have been described, but not systematically assessed. We sought to analyze this complication in a contemporary HGG cohort. METHODS: A retrospective review of HGG patients treated between 2007 and 2013 was performed, patients with space-occupying tumor bed cysts were identified and their hospital notes reviewed for relevant variables...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28512046/risk-factors-for-preoperative-seizures-and-loss-of-seizure-control-in-patients-undergoing-surgery-for-metastatic-brain-tumors
#18
Adela Wu, Jon D Weingart, Gary L Gallia, Michael Lim, Henry Brem, Chetan Bettegowda, Kaisorn L Chaichana
OBJECTIVE: Metastatic brain tumors are the most common brain tumors in adults. Patients with metastatic brain tumors have poor prognoses with median survival of 6-12 months. Seizures are a major presenting symptom and cause of morbidity and mortality. Risk factors for the onset of preoperative seizures and postoperative seizure control are examined. METHODS: Adult patients who underwent resection of one or more brain metastases at a single institution between 1998 and 2011 were retrospectively reviewed...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28501423/teratoma-of-the-nervous-system-a-case-series
#19
Hussein Algahtani, Bader Shirah, Ahad Abdullah, Abdulrahman Bazaid
Teratoma is a common form of germ cell tumors composed of multiple tissues foreign to the site in which arise with a histological representation of all three germ cell layers. Intracranial teratomas are very rare. In this study, we report three cases of intracranial teratomas with an interesting clinical course, neuroradiology, and outcome. In addition, we review the literature and convey important messages to the neuroscience community regarding issues related to the management of these rare tumors. The present cases are interesting examples of intracranial teratoma in terms of location of the tumor and neuroimaging findings...
May 10, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28499902/dumbbell-shaped-jugular-foramen-tumors-extending-to-the-neck-surgical-considerations-based-on-imaging-findings
#20
J He, J H Wan, B Zhao, H Q Cai, Y H Wu, X J Li, H P Qian, X L Meng
OBJECTIVE: Dumbbell-shaped jugular foramen tumors (DSJFTs) extending to the neck present diagnostic and management difficulties because of their rarity, various pathologies and multidisciplinary involvement. Accurate imaging findings are of great importance for surgical planning and clinical outcomes. However, few articles have discussed this issue to date. METHODS: Thirty-one patients with DSJFTs extending to the neck were surgically treated in a single stage at our institute...
May 9, 2017: World Neurosurgery
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