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https://www.readbyqxmd.com/read/28735139/cumulative-intracranial-tumor-volume-and-number-of-brain-metastasis-as-predictors-of-developing-new-lesions-after-stereotactic-radiosurgery-for-brain-metastasis
#1
Mayur Sharma, Xuefei Jia, Manmeet Ahluwalia, Gene H Barnett, Michael A Vogelbaum, Samuel T Chao, John H Suh, Erin S Murphy, Jennifer S Yu, Lilyana Angelov, Alireza M Mohammadi
INTRODUCTION: The aim of our study was to identify risk factors associated with early distant radiographic progression in patients undergoing stereotactic radiosurgery (SRS) for brain metastases (BM). METHODS: Following IRB approval, data of 1427 patients (4283 BM lesions) who were treated using SRS at Cleveland Clinic from 2000-2012 were collected. Local tumor progression (LTP), distant tumor progression (DTP) and radiographic radiation necrosis (RN) were the primary end points...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735134/intraventricular-meningioma-resection-with-post-operative-ischemia-of-the-lateral-geniculate-nucleus
#2
Saman Sizdahkhani, Stephen T Magill, Michael W McDermott
BACKGROUND: Intraventricular meningiomas (IVMs) comprise 0.5-3% of intracranial meningiomas. They often cause obstructive hydrocephalus and are commonly treated with surgical resection or stereotactic radiosurgery. OBJECTIVE: To describe the surgical approaches and resection techniques needed to approach intraventricular tumors, while highlighting the eloquent anatomy and blood supply surrounding the ventricular system in order to avoid neurological injury. METHODS: Two cases of left atrial IVMs that were complicated by postoperative lateral geniculate nucleus (LGN) ischemia and resultant temporary contralateral quadrantanopia are described...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735124/inherent-tumor-characteristics-that-limit-effective-and-safe-resection-of-giant-nonfunctioning-pituitary-adenomas
#3
Hiroshi Nishioka, Takayuki Hara, Yuichi Nagata, Noriaki Fukuhara, Mitsuo Yamaguchi-Okada, Shozo Yamada
BACKGROUND: Surgical treatment of giant pituitary adenomas is sometimes challenging. We present our surgical series of giant nonfunctioning adenomas to shed light on the limitations of effective and safe tumor resection. METHODS: The preoperative tumor characteristics, surgical approaches, outcome, and histology of giant nonfunctioning adenoma (>40 mm) in 128 consecutive surgical patients are reviewed. The follow-up period ranged from 19 to 113 (mean 62.2) months...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735121/survival-patterns-of-5750-srs-treated-brain-metastasis-patients-as-a-function-of-the-number-of-lesions
#4
Mir Amaan Ali, Brian R Hirshman, Bayard Wilson, Kate T Carroll, James A Proudfoot, Steven J Goetsch, John F Alksne, Kenneth Ott, Hitoshi Aiyama, Osamu Nagano, Bob S Carter, Gerald Fogarty, Angela Hong, Toru Serizawa, Masaaki Yamamoto, Clark C Chen
BACKGROUND: The number of brain metastases (BM) plays an important role in the decision between stereotactic radiosurgery (SRS) and whole brain radiation therapy (WBRT). METHODS: We analyzed the survival of 5750 SRS-treated BM patients as a function of BM number. Survival analyses were performed using Kaplan-Meier analysis as well as univariate and multivariate Cox proportional hazards models. RESULTS: BM patients were first categorized as those with 1, 2-4, and 5-10 BM based on the scheme proposed by Yamamoto et al (Lancet Oncology 2014)...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28733870/rethinking-childhood-ependymoma-a-retrospective-multi-center-analysis-reveals-poor-long-term-overall-survival
#5
Amanda E Marinoff, Clement Ma, Dongjing Guo, Matija Snuderl, Karen D Wright, Peter E Manley, Hasan Al-Sayegh, Claire E Sinai, Nicole J Ullrich, Karen Marcus, Daphne Haas-Kogan, Liliana Goumnerova, Wendy B London, Mark W Kieran, Susan N Chi, Jason Fangusaro, Pratiti Bandopadhayay
Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial ependymoma, who were treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Chicago's Ann & Robert H. Lurie Children's Hospital between 1985 and 2008, and an additional 360 ependymoma patients identified from the Surveillance Epidemiology and End Results (SEER) database...
July 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28732417/expanding-spectrum-and-diversifying-role-of-laser-beam-from-intraoperative-cranial-surgery-adjunct-to-magnetic-resonance-guided-minimally-invasive-thermal-laser-ablation-therapy-for-intracranial-tumor
#6
https://www.readbyqxmd.com/read/28731197/metastatic-gallbladder-carcinoma-in-meningioma-a-case-report
#7
Burak Eren, Feyza Karagoz Guzey, Ilker Gulec, Azmi Tufan
Metastases from tumors to systemic cancers are rare. The most common intracranial recipient tumor is meningioma. Metastasis from gallbladder cancer has been previously reported from only one patient during autopsy. We present the case of a 72-year-old woman who underwent surgery for right frontal skull base meningioma.The tumor was completely removed. Histological specimens showed gallbladder carcinomatous metastasis with diffuse neuroendocrine differentiation in meningothelial meningioma. The Ki-67 proliferation index of the meningioma was 3%...
June 2, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28725519/intracranial-hemangiopericytomas-recurrence-metastasis-and-radiotherapy
#8
Ankur R Patel, Bruno C Flores, Vin Shen Ban, Kimmo J Hatanpaa, Bruce E Mickey, Samuel L Barnett
Background  Intracranial hemangiopericytomas (HPCs) are characterized by high recurrence rates and extracranial metastases. Radiotherapy provides an adjunct to surgery, but the timing of therapy and the patients most likely to benefit remain unclear. Methods  A retrospective review of 20 patients with HPC treated at the University of Texas Southwestern Medical Center between 1985 and 2014 was conducted. Recurrence and metastasis rates along with overall survival (OS) were characterized based on therapeutic approach and tumor pathology using Kaplan-Meier and Cox regression analyses...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28725514/gamma-knife-stereotactic-radiosurgery-for-grade-2-meningiomas
#9
Tamer Refaat, Michelle Gentile, Sean Sachdev, Prarthana Dalal, Anish Butala, Stanley Gutiontov, Irene Helenowksi, Plato Lee, Vythialinga Sathiaseelan, Orin Bloch, James Chandler, John A Kalapurakal
Purpose  This study aims to report long-term clinical outcomes after Gamma Knife radiosurgery (GKRS) for intracranial grade 2 meningiomas. Methods  In this Institutional Review Board approved study, we reviewed records of all patients with grade 2 meningiomas treated with GKRS between 1998 and 2014. Results  A total of 97 postoperative histopathologically confirmed grade 2 meningiomas in 75 patients were treated and are included in this study. After a mean follow-up of 41 months, 28 meningiomas had local recurrence (29...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28721902/permeability-of-brain-tumor-vessels-induced-by-uniform-or-spatially-microfractionated-synchrotron-radiation-therapies
#10
Audrey Bouchet, Marine Potez, Nicolas Coquery, Claire Rome, Benjamin Lemasson, Elke Bräuer-Krisch, Chantal Rémy, Jean Laissue, Emmanuel L Barbier, Valentin Djonov, Raphael Serduc
PURPOSE: To compare the blood-brain barrier permeability changes induced by synchrotron microbeam radiation therapy (MRT, which relies on spatial fractionation of the incident x-ray beam into parallel micron-wide beams) with changes induced by a spatially uniform synchrotron x-ray radiation therapy. METHODS AND MATERIALS: Male rats bearing malignant intracranial F98 gliomas were randomized into 3 groups: untreated, exposed to MRT (peak and valley dose: 241 and 10...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721351/cerebral-epidural-abscess-secondary-to-blastomyces-masquerading-as-an-epidermoid-tumor
#11
Cody Doberstein, Abass Noor, David Choi, Jacob Smith, Darren Groh, Leonard Mermel, Curtis Doberstein
There have been infrequent reports of isolated central nervous system blastomycosis. We report a case of intracranial epidural abscess secondary to Blastomyces dermatitidis in a patient residing in Rhode Island with a history of remote travel to an endemic area. The clinical, radiographic, and pathologic features of this unique case are reviewed.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28720529/population-rcharacteristics-and-progressive-disability-in-neuofibromatosis-type-2
#12
Kensho Iwatate, Takeshi Yokoo, Eriko Iwatate, Masahiro Ichikawa, Taku Sato, Masazumi Fujii, Jun Sakuma, Kiyoshi Saito
OBJECTIVE: To characterize the clinical features of the NF2 population and determine prognostic risk factors for progressive disabilities. METHODS: In this retrospective cohort study of the Japanese national NF2 registry between 2009-2013, various clinical data (demographic, history, oncological, and neurological) of 807 patients with diagnosis of NF2 were analyzed. The overall severity of neurological disability was assessed using a comprehensive 25-point scoring system encompassing a wide variety of neurological deficits...
July 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28719459/coagulation-management-in-patients-undergoing-neurosurgical-procedures
#13
Chiara Robba, Rita Bertuetti, Frank Rasulo, Alessando Bertuccio, Basil Matta
PURPOSE OF REVIEW: Management of coagulation in neurosurgical procedures is challenging. In this contest, it is imperative to avoid further intracranial bleeding. Perioperative bleeding can be associated with a number of factors, including anticoagulant drugs and coagulation status but is also linked to the characteristic and the site of the intracranial disorder. The aim of this review will be to focus primarily on the new evidence regarding the management of coagulation in patients undergoing craniotomy for neurosurgical procedures...
July 14, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28713041/chains-of-magnetosomes-with-controlled-endotoxin-release-and-partial-tumor-occupation-induce-full-destruction-of-intracranial-u87-luc-glioma-in-mice-under-the-application-of-an-alternating-magnetic-field
#14
Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, François Guyot, Imène Chebbi
Previous studies showed that magnetic hyperthermia could efficiently destroy tumors both preclinically and clinically, especially glioma. However, antitumor efficacy remained suboptimal and therefore required further improvements. Here, we introduce a new type of nanoparticles synthesized by magnetotactic bacteria, called magnetosomes, with improved properties compared with commonly used chemically synthesized nanoparticles. Indeed, mice bearing intracranial U87-Luc glioma tumors injected with 13μg of nanoparticles per mm(3) of tumor followed by 12 to 15 of 30min alternating magnetic field applications displayed either full tumor disappearance in 40% of mice or no tumor regression using magnetosomes or chemically synthesized nanoparticles, respectively...
July 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28712276/optimal-dose-and-volume-for-postoperative-radiotherapy-in-brain-oligometastases-from-lung-cancer-a-retrospective-study
#15
Seung Yeun Chung, Jong Hee Chang, Hye Ryun Kim, Byoung Chul Cho, Chang Geol Lee, Chang-Ok Suh
PURPOSE: To evaluate intracranial control after surgical resection according to the adjuvant treatment received in order to assess the optimal radiotherapy (RT) dose and volume. MATERIALS AND METHODS: Between 2003 and 2015, a total of 53 patients with brain oligometastases from non-small cell lung cancer (NSCLC) underwent metastasectomy. The patients were divided into three groups according to the adjuvant treatment received: whole brain radiotherapy (WBRT) ± boost (WBRT ± boost group, n = 26), local RT/Gamma Knife surgery (local RT group, n = 14), and the observation group (n = 13)...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28711903/notch-system-is-differentially-expressed-and-activated-in-pituitary-adenomas-of-distinct-histotype-tumor-cell-lines-and-normal-pituitaries
#16
Sofia Perrone, Lautaro Zubeldia-Brenner, Elias Gazza, Gianina Demarchi, Leticia Baccarini, Agustin Baricalla, Freya Mertens, Guillermina Luque, Hugo Vankelecom, Silvia Berner, Damasia Becu-Villalobos, Carolina Cristina
Pituitary adenomas are among the most frequent intracranial neoplasms and treatment depends on tumor subtype and clinical features. Unfortunately, non responder cases occur, then new molecular targets are needed.Notch system component expression and activation data are scarce in pituitary tumorigenesis, we therefore aimed to characterize Notch system in pituitary tumors of different histotype. In human pituitary adenomas we showed NOTCH1-4 receptors, JAGGED1 ligand and HES1 target gene expression with positive correlations between NOTCH1,2,4 and HES1, and NOTCH3 and JAGGED1 denoting Notch system activation in a subset of tumors...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28711294/clinical-management-and-survival-of-patients-with-central-nervous-system-hemangiopericytoma-in-the-national-cancer-database
#17
Daniel M Trifiletti, Gautam U Mehta, Surbhi Grover, Jason P Sheehan
PURPOSE/OBJECTIVES: Hemangiopericytomas are rare central nervous system (CNS) tumors. We sought to investigate existing clinical management strategies and overall survival (OS) among patients with hemangiopericytomas of the CNS. METHODS/MATERIALS: All patients diagnosed with CNS hemangiopericytoma from 2004 to 2014 in the National Cancer Database were included. Clinical and treatment-related characteristics were analyzed for an association with OS following diagnosis using univariable and multivariable analyses...
July 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28708793/patulous-eustachian-tube-and-otitis-media-with-effusion-as-complications-after-trigeminal-nerve-injury
#18
Ryoukichi Ikeda, Toshimitsu Kobayashi, Masayuki Yoshida, Naohiro Yoshida, Toshiaki Kikuchi, Takeshi Oshima, Tetsuaki Kawase, Yukio Katori
OBJECTIVES: To describe three patients of patulous Eustachian tube (pET) after trigeminal nerve injury and to demonstrate for the first time their magnetic resonance imaging (MRI) findings to hypothesize the mechanism of the pET after trigeminal nerve injury. PATIENTS: Three patients presented with autophony after trigeminal nerve injury caused by the removal of intracranial tumors. MAIN OUTCOME MEASURES: Clinical patient records, audiological data, and MRI...
July 13, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28708652/clinical-application-of-multimodal-neuronavigation-system-in-neuroendoscope-assisted-skull-base-chordoma-resection
#19
Xin Wang, Long Li, Yibao Wang, Jinqu Hu, Jinpeng Zhou, Zhitao Jing, Anhua Wu
Skull base chordoma is a rare tumor arising from embryonic remnants of the notochord with invasive potential. Due to the destruction of osseous landmarks and invasion of surrounding structures, surgical resection is challenging. The authors explored the clinical value of a multimodal neuronavigation system in skull base chordoma resection using a neuroendoscope. Between January 2012 and January 2016, the authors utilized neuroendoscopy to excise skull base chordoma in 93 patients. The authors performed 45 operations assisted by multimodal neuronavigation (neuronavigation group) and 48 without intraoperative imaging guidance (control group)...
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28705818/intracranial-perishunt-catheter-fluid-collections-with-edema-a-sign-of-shunt-malfunction-correlation-of-ct-mri-and-nuclear-medicine-findings
#20
H A Kale, A Muthukrishnan, S V Hegde, V Agarwal
Fluid collections with edema along the intracranial tract of ventriculoperitoneal shunt catheters in adults are rare and are more frequently seen in children. The imaging appearance of these fluid collections is frequently confusing and presents a diagnostic dilemma. We present 6 cases of adult patients noted to have collections with edema along the tract of ventriculoperitoneal shunt catheters. To our knowledge, there are no previous studies correlating the CT/MR imaging findings with nuclear medicine scans in this entity...
July 13, 2017: AJNR. American Journal of Neuroradiology
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