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https://www.readbyqxmd.com/read/28453588/-diverticular-disease-myths-and-realities
#1
Daniela Fluxá, Rodrigo Quera
Diverticulosis and diverticular disease of the colon are common conditions in Western countries. The incidence and prevalence of these diseases are increasing and becoming significant for health systems. A growing body of knowledge is shifting the paradigm of the pathogenesis and treatment of diverticular disease. Low-grade inflammation, altered intestinal microbiota, visceral hypersensitivity, and abnormal colonic motility have been identified as factors leading to diverticular disease. The risk of developing diverticulitis among individuals with diverticulosis is lower than 10 to 25%...
February 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28449386/influence-of-a-two-to-six-year-physical-education-intervention-on-scholastic-performance-the-champs-study-dk
#2
Anna Bugge, Sören Möller, Jakob Tarp, Charles H Hillman, Rodrigo Antunes Lima, Anne Kaer Gejl, Heidi Klakk, Niels Wedderkopp
AIM: To investigate the influence of a school-based intervention with a tripling of physical education (PE) lessons from two (90 min) to six lessons per week (270 min) on scholastic performance. METHODS: This study is part of the CHAMPS study-DK, a quasi-experimental study that began in 2008. The intervention group consisted of six schools and the control group consisted of four matched schools (mean age at baseline = 8.4 years, kindergarten class-4(th) grade). Academic performance was extracted from the national test system from 2010- 2014 (Math and Danish were measured at 3(rd) and 6(th) , and 2(nd) , 4(th) and 6(th) grades, respectively)...
April 27, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28448871/immunomodulatory-effects-of-stem-cells-therapeutic-option-for-neurodegenerative-disorders
#3
REVIEW
Martin Caprnda, Peter Kubatka, Katarina Gazdikova, Iveta Gasparova, Vanda Valentova, Nadezda Stollarova, Giampiero La Rocca, Nazarii Kobyliak, Jozef Dragasek, Ioana Mozos, Robert Prosecky, Dario Siniscalco, Dietrich Büsselberg, Luis Rodrigo, Peter Kruzliak
Stem cells have the capability of self-renewal and can differentiate into different cell types that might be used in regenerative medicine. Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) currently lack effective treatments. Although stem cell therapy is still on the way from bench to bedside, we consider that it might provide new hope for patients suffering with neurodegenerative diseases. In this article, we will give an overview of recent studies on the potential therapeutic use of mesenchymal stem cells (MSCs), neural stem cells (NSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and perinatal stem cells to neurodegenerative disorders and we will describe their immunomodulatory mechanisms of action in specific therapeutic modalities...
April 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28448719/use-of-native-aquatic-macrophytes-in-the-reduction-of-organic-matter-from-dairy-effluents
#4
Rita de Cássia Souza de Queiroz Lopes, Rodrigo Santos Andrade, Isadora Rosário Dantas, Vinícius de Souza Ribeiro, Luciano Brito Rodrigues Neto, José Adolfo de Almeida Neto
Considering the diversity and the unexplored potential of regional aquatic flora, this study aimed to identify and analyze the potential of native aquatic macrophytes to reduce the organic matter of dairy wastewater using experimental constructed wetlands. The dairy wastewater had an initial average COD of 7,414.63 mg/L and then was diluted to 3,133.16 mg/L (D1) and to 2,506.53 mg/L (D2). Total solids, COD, temperature, and pH analyses were performed, and the BOD was estimated from the COD values. The best performance in the reduction of the organic matter was observed for Polygonum sp...
April 27, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28448642/inferior-survival-rates-after-chemoradiation-for-rectal-cancer-without-surgery
#5
Angelita Habr-Gama, Guilherme Pagin São Julião, Rodrigo O Perez
No abstract text is available yet for this article.
April 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28448552/transcriptomic-analysis-of-the-hepatic-response-to-stress-in-the-red-cusk-eel-genypterus-chilensis-insights-into-lipid-metabolism-oxidative-stress-and-liver-steatosis
#6
Sebastian Naour, Brisa M Espinoza, Jorge E Aedo, Rodrigo Zuloaga, Jonathan Maldonado, Macarena Bastias-Molina, Herman Silva, Claudio Meneses, Cristian Gallardo-Escarate, Alfredo Molina, Juan Antonio Valdés
Teleosts exhibit a broad divergence in their adaptive response to stress, depending on the magnitude, duration, and frequency of stressors and the species receiving the stimulus. We have previously reported that the red cusk-eel (Genypterus chilensis), an important marine farmed fish, shows a physiological response to stress that results in increased skeletal muscle atrophy mediated by over-expression of components of the ubiquitin proteasome and autophagy-lysosomal systems. To better understand the systemic effects of stress on the red cusk-eel metabolism, the present study assessed the transcriptomic hepatic response to repetitive handling-stress...
2017: PloS One
https://www.readbyqxmd.com/read/28447893/ultra-small-solid-archaeolipid-nanoparticles-for-active-targeting-to-macrophages-of-the-inflamed-mucosa
#7
Leticia Herminia Higa, Horacio Emanuel Jerez, Marcelo Alexandre de Farias, Rodrigo Villares Portugal, Eder Lilia Romero, Maria Jose Morilla
AIM: Develop nanoparticulate agents for oral targeted delivery of dexamethasone (Dex) to macrophages of inflamed mucosa. MATERIALS & METHODS: Solid archaeolipid nanoparticles (SAN-Dex) (compritol/Halorubrum tebenquichense polar archaeolipids/soybean phosphatidylcholine/Tween-80 4; 0.9; 0.3; 3% w/w) loaded with Dex were prepared. Their mucopenetration, stability under digestion and in vitro anti-inflammatory activity, were determined. RESULTS: Ultra-small SAN-Dex strongly reduced the levels of TNF-α, IL-6 and IL-12 on J774A1 cells stimulated with lipopolysaccharides as compared with free Dex or loaded in ordinary solid lipid nanoparticles-Dex...
April 27, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28446912/temporal-and-spatial-variability-of-fungal-structures-and-host-responses-in-an-incompatible-rust-wheat-interaction
#8
Chris K Sørensen, Rodrigo Labouriau, Mogens S Hovmøller
Information about temporal and spatial variability of fungal structures and host responses is scarce in comparison to the vast amount of genetic, biochemical, and physiological studies of host-pathogen interactions. In this study, we used avirulent wild type and virulent mutant isolates of Puccinia striiformis to characterize the interactions in wheat carrying yellow rust Yr2 resistance. Both conventional and advanced microscopic techniques were used for a detailed study of morphology and growth of fungal colonies and associated host cell responses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28446241/polyunsaturated-fatty-acid-receptors-gpr40-and-gpr120-are-expressed-in-the-hypothalamus-and-control-energy-homeostasis-and-inflammation
#9
Nathalia R V Dragano, Carina Solon, Albina F Ramalho, Rodrigo F de Moura, Daniela S Razolli, Elisabeth Christiansen, Carlos Azevedo, Trond Ulven, Licio A Velloso
BACKGROUND: The consumption of large amounts of dietary fats is one of the most important environmental factors contributing to the development of obesity and metabolic disorders. GPR120 and GPR40 are polyunsaturated fatty acid receptors that exert a number of systemic effects that are beneficial for metabolic and inflammatory diseases. Here, we evaluate the expression and potential role of hypothalamic GPR120 and GPR40 as targets for the treatment of obesity. METHODS: Male Swiss (6-weeks old), were fed with a high fat diet (HFD, 60% of kcal from fat) for 4 weeks...
April 26, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28446170/latin-america-validation-of-faced-score-in-patients-with-bronchiectasis-an-analysis-of-six-cohorts
#10
Rodrigo Athanazio, Mônica Corso Pereira, Georgina Gramblicka, Fernando Cavalcanti-Lundgren, Mara Fernandes de Figueiredo, Francisco Arancibia, Samia Rached, David de la Rosa, Luis Máiz-Carro, Rosa Girón, Casilda Olveira, Concepción Prados, Miguel Angel Martinez-Garcia
BACKGROUND: The FACED score is an easy-to-use multidimensional grading system that has demonstrated an excellent prognostic value for mortality in patients with bronchiectasis. A Spanish group developed the score but no multicenter international validation has yet been published. METHODS: Retrospective and multicenter study conducted in six historical cohorts of patients from Latin America including 651 patients with bronchiectasis. Clinical, microbiological, functional, and radiological variables were collected, following the same criteria used in the original FACED score study...
April 26, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28446154/effects-of-escitalopram-and-paroxetine-on-mtorc1-signaling-in-the-rat-hippocampus-under-chronic-restraint-stress
#11
Mi Kyoung Seo, Cheol Min Choi, Roger S McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park, Jung Goo Lee
BACKGROUND: Recent studies have suggested that the activation of mammalian target of rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, the present study evaluated whether antidepressant drugs would exert differential effects on mTOR signaling in the rat hippocampus under conditions of chronic restraint stress. Male Sprague-Dawley rats were subjected to restraint stress for 6 h/days for 21 days with either escitalopram (10 mg/kg) or paroxetine (10 mg/kg) administered after the chronic stress procedure...
April 26, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28445703/sensitivity-and-specificity-of-laser-scanning-in-vivo-confocal-microscopy-for-filamentous-fungal-keratitis-role-of-observer-experience
#12
Ahmad Kheirkhah, Zeba A Syed, Vannarut Satitpitakul, Sunali Goyal, Rodrigo Müller, Elmer Y Tu, Reza Dana
PURPOSE: To determine sensitivity and specificity of laser-scanning in vivo confocal microscopy (LS-IVCM) for detection of filamentous fungi in patients with microbial keratitis and to evaluate the effect of observer's imaging experience on these parameters. DESIGN: Retrospective, reliability study METHODS: This study included 21 patients with filamentous fungal keratitis and 24 patients with bacterial keratitis (as controls). The etiology of infection was confirmed based on the response to specific therapy regardless of culture results...
April 23, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28445546/a-coral-algal-phase-shift-in-mesoamerica-not-driven-by-changes-in-herbivorous-fish-abundance
#13
Jesús Ernesto Arias-González, Tak Fung, Robert M Seymour, Joaquín Rodrigo Garza-Pérez, Gilberto Acosta-González, Yves-Marie Bozec, Craig R Johnson
Coral-algal phase shifts in which coral cover declines to low levels and is replaced by algae have often been documented on coral reefs worldwide. This has motivated coral reef management responses that include restriction and regulation of fishing, e.g. herbivorous fish species. However, there is evidence that eutrophication and sedimentation can be at least as important as a reduction in herbivory in causing phase shifts. These threats arise from coastal development leading to increased nutrient and sediment loads, which stimulate algal growth and negatively impact corals respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28445192/one-year-clinical-outcomes-of-a-corneal-inlay-for-presbyopia
#14
Sandra M C Beer, Rodrigo Santos, Eliane M Nakano, Flavio Hirai, Enrico J Nitschke, Claudia Francesconi, Mauro Campos
PURPOSE: To report the results of a 1-year follow-up analysis of the safety and efficacy of the Flexivue Microlens corneal inlay. METHODS: The Flexivue Microlens corneal inlay was implanted in the nondominant eye of patients with emmetropic presbyopia (a spherical equivalent of -0.5 to 1.00 diopter) after the creation of a 300-μm deep stromal pocket, using a femtosecond laser. The patients were followed up according to a clinical protocol involving refraction, anterior segment imaging analysis (Oculyzer), and optical quality analysis (OPD-Scan)...
April 25, 2017: Cornea
https://www.readbyqxmd.com/read/28444975/dissociation-between-the-neural-correlates-of-conscious-face-perception-and-visual-attention
#15
Joaquin Navajas, Aleksander W Nitka, Rodrigo Quian Quiroga
Given the higher chance to recognize attended compared to unattended stimuli, the specific neural correlates of these two processes, attention and awareness, tend to be intermingled in experimental designs. In this study, we dissociated the neural correlates of conscious face perception from the effects of visual attention. To do this, we presented faces at the threshold of awareness and manipulated attention through the use of exogenous prestimulus cues. We show that the N170 component, a scalp EEG marker of face perception, was modulated independently by attention and by awareness...
April 26, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28444869/assessment-of-the-usage-of-biodegradable-polymeric-matrix-in-vaginal-devices-to-sustain-progesterone-release-in-cows
#16
José Rodrigo Valim Pimentel, Milton Maturana Filho, Lucio Cardozo-Filho, José Augusto M Agnelli, Jefter Nascimento, Ed Hoffmann Madureira
The usage of timed artificial insemination (TAI) at a low cost leading to better reproductive rates has been the aim of several research groups in the field. Usually during TAI protocols, sustained progesterone (P4 ) release devices are employed. Most devices are constituted of a nylon skeleton covered with a silicon layer with P4 . A device based on biopolymers was developed in order to reduce costs and decrease its environmental impact. In this study, we compared the kinetics of sustained progesterone release among devices manufactured with a polymeric blend made of polyhydroxybutyrate-valerate (PHBV) and poly-ε-caprolactone (PCL) (DISP) which were compared with DIB® (Internal Bovine Device) used as the control...
April 25, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28444098/the-cerebrospinal-fluid-in-multiple-sclerosis-far-beyond-the-bands
#17
Renan Barros Domingues, Gustavo Bruniera Peres Fernandes, Fernando Brunale Vilela de Moura Leite, Charles Peter Tilbery, Rodrigo Barbosa Thomaz, Gisele Sampaio Silva, Cristóvão Luis Pitangueira Mangueira, Carlos Augusto Senne Soares
The cerebrospinal fluid analysis has been employed for supporting multiple sclerosis diagnosis and ruling out the differential diagnoses. The most classical findings reflect the inflammatory nature of the disease, including mild pleocytosis, mild protein increase, intrathecal synthesis of immunoglobulin G, and, most typically, the presence of oligoclonal bands. In recent years, new biomarkers have emerged in the context of multiple sclerosis. The search for new biomarkers reflect the need of a better evaluation of disease activity, disease progression, and treatment efficiency...
January 2017: Einstein
https://www.readbyqxmd.com/read/28444093/electrical-stimulation-attenuates-morphological-alterations-and-prevents-atrophy-of-the-denervated-cranial-tibial-muscle
#18
Cleuber Rodrigo de Souza Bueno, Mizael Pereira, Idvaldo Aparecido Favaretto, Carlos Henrique Fachin Bortoluci, Thais Caroline Pereira Dos Santos, Daniel Ventura Dias, Letícia Rossi Daré, Geraldo Marco Rosa
Objective: To investigate if electrical stimulation through Russian current is able to maintain morphology of the cranial tibial muscle of experimentally denervated rats. Methods: Thirty-six Wistar rats were divided into four groups: the Initial Control Group, Final Control Group, Experimental Denervated and Treated Group, Experimental Denervated Group. The electrostimulation was performed with a protocol of Russian current applied three times per week, for 45 days...
January 2017: Einstein
https://www.readbyqxmd.com/read/28444090/depression-and-anxiety-in-a-case-series-of-amyotrophic-lateral-sclerosis-frequency-and-association-with-clinical-features
#19
Laura de Godoy Rousseff Prado, Isabella Carolina Santos Bicalho, Mauro Vidigal-Lopes, Vitor de Godoy Rousseff Prado, Rodrigo Santiago Gomez, Leonardo Cruz de Souza, Antônio Lúcio Teixeira
Objective: To investigate the frequency of anxiety and depression and their association with clinical features of amyotrophic lateral sclerosis. Methods: This is a cross-sectional and descriptive study including a consecutive series of patients with sporadic amyotrophic lateral sclerosis according to Awaji's criteria. Patients underwent clinical and psychiatric assessment (anxiety and depression symptoms). Results: We included 76 patients...
2017: Einstein
https://www.readbyqxmd.com/read/28444079/use-of-noninvasive-ventilation-in-severe-acute-respiratory-distress-syndrome-due-to-accidental-chlorine-inhalation-a-case-report
#20
Adriano Medina Matos, Rodrigo Ribeiro de Oliveira, Mauro Martins Lippi, Rodrigo Ryoji Takatani, Wilson de Oliveira
Acute respiratory distress syndrome is characterized by diffuse inflammatory lung injury and is classified as mild, moderate, and severe. Clinically, hypoxemia, bilateral opacities in lung images, and decreased pulmonary compliance are observed. Sepsis is one of the most prevalent causes of this condition (30 - 50%). Among the direct causes of acute respiratory distress syndrome, chlorine inhalation is an uncommon cause, generating mucosal and airway irritation in most cases. We present a case of severe acute respiratory distress syndrome after accidental inhalation of chlorine in a swimming pool, with noninvasive ventilation used as a treatment with good response in this case...
January 2017: Revista Brasileira de Terapia Intensiva
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