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https://www.readbyqxmd.com/read/29792652/prostate-cancer-local-treatment-after-radiorecurrence-salvage-cryoablation
#1
EDITORIAL
Rodrigo Donalisio da Silva, Fernando J Kim
No abstract text is available yet for this article.
May 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29791897/cutis-marmorata-telangiectatica-congenita-presenting-as-a-fetal-hemothorax
#2
Rodrigo A Mon, Ellen Mozurkewich, Marjorie C Treadwell, Deborah R Berman
We report a case of a fetus diagnosed at 28 weeks' gestation with a spontaneous prenatal hemothorax. Fetal intervention consisted of 2 thoracenteses with analysis of the pleural effusion. The pregnancy was further complicated by recurrence of the hemothorax, with subsequent mediastinal shift, hydrops, and nonreassuring antenatal testing requiring delivery at 31 weeks' gestation. Postnatal workup established the diagnoses of cutis marmorata telangiectatica congenita (CMTC) and pulmonary lymphangiectasia. The child is currently 4 years old and without any active medical issues or sequelae from the CMTC, pulmonary lymphangiectasia, or prenatal interventions...
May 23, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29791774/serotonergic-regulation-of-insulin-secretion
#3
REVIEW
Luis Rodrigo Cataldo Bascuñan, Claire Lyons, Hedvig Bennet, Isabella Artner, Malin Fex
The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signaling network in islets involving 5-HT is being unraveled. With more than fourteen different 5-HT receptors expressed in human islets, and receptor independent mechanisms in insulin producing β-cells, our understanding of 5-HT's regulation of insulin secretion is increasing...
May 23, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29791658/self-report-of-psychological-symptoms-in-hypoparathyroidism-patients-on-conventional-therapy
#4
Amanda J Arneiro, Bianca C C Duarte, Rodrigo M Kulchetscki, Victor B S Cury, Maicon P Lopes, Breno S Kliemann, Ileana B Bini, Marcos Assad, Gleyne L K Biagini, Victoria Z C Borba, Carolina A Moreira
OBJECTIVE: Hypoparathyroidism is characterized by parathyroid hormone deficiency and hypocalcemia. It has been demonstrated that these patients may also present psychiatric symptoms and decrease of quality of life. The aims of this study were to evaluate the presence of psychopathological symptoms in a cohort of patients with hypoparathyroidism and compare to a control group. SUBJECTS AND METHODS: Patients were submitted to a cross-sectional Symptom Checklist-90-R (SCL-90-R) questionnaire that evaluates psychopathological symptoms by means of the Global Severity Index (GSI), Positive Symptoms Total (PST) and Positive Symptom Distress Index (PSDI)...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791600/unilateral-spatial-neglect-in-the-acute-phase-of-ischemic-stroke-can-predict-long-term-disability-and-functional-capacity
#5
Gustavo José Luvizutto, Augusta Fabiana Moliga, Gabriela Rizzo Soares Rizzatti, Marcelo Ortolani Fogaroli, Eduardo de Moura Neto, Hélio Rubens de Carvalho Nunes, Luiz Antônio de Lima Resende, Rodrigo Bazan
OBJECTIVE: The aim of this study was to assess the relationship between the degree of unilateral spatial neglect during the acute phase of stroke and long-term functional independence. METHODS: This was a prospective study of right ischemic stroke patients in which the independent variable was the degree of spatial neglect and the outcome that was measured was functional independence. The potential confounding factors included sex, age, stroke severity, topography of the lesion, risk factors, glycemia and the treatment received...
May 21, 2018: Clinics
https://www.readbyqxmd.com/read/29791574/applicability-of-longitudinal-strain-of-left-ventricle-in-unstable-angina
#6
Natasha Soares Simões Dos Santos, Andrea de Andrade Vilela, Rodrigo Bellio de Mattos Barretto, Marcela Paganelli do Vale, Mariana Oliveira Rezende, Murilo Castro Ferreira, Alexandre José Aguiar Andrade, Nelson Henrique Goes Scorsioni, Olívia Ximenes de Queiroga, David Le Bihan
BACKGROUND: Unstable angina (UA) is a common cause of hospital admission; risk stratification helps determine strategies for treatment. OBJECTIVE: To determine the applicability of two-dimensional longitudinal strain (SL2D) for the identification of myocardial ischemia in patients with UA. METHODS: Cross-sectional, descriptive, observational study lasting 60 days. The sample consisted of 78 patients, of which fifteen (19.2%) were eligible for longitudinal strain analysis...
April 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29791465/predictors-of-subclinical-carotid-atherosclerosis-in-middle-aged-women
#7
Isly L de Barros, Laura Costa, Bento Bezerra, Rafael Gomes, Natanael Morais, Célia M C Strunz, Moacir Novaes, Otávio C E Gebara, Rodrigo Pinto Pedrosa, José C Nicolau
BACKGROUND: Traditional strategies for primary cardiovascular prevention have been insufficient in reducing the high rates of coronary ischemic events in women, probably because these women are often stratified into low-risk groups. However, cardiovascular diseases continue to be the main cause of morbidity and mortality in women worldwide. We hypothesized that carotid atherosclerosis (CA) is common in middle-aged women. METHODS: We prospectively evaluated asymptomatic peri- and post-menopausal women with no cardiovascular diseases or the use of hormone therapy from two gynecologic clinics...
2018: PloS One
https://www.readbyqxmd.com/read/29790638/comparative-efficacy-and-acceptability-of-anti-diabetic-agents-for-alzheimer-s-disease-and-mild-cognitive-impairment-a-systematic-review-and-network-meta-analysis
#8
Bing Cao, Joshua D Rosenblat, Elisa Brietzke, Caroline Park, Yena Lee, Natalie Musial, Zihang Pan, Rodrigo B Mansur, Roger S McIntyre
The current meta-analysis compares the efficacy (i.e., pro-cognitive effects) and acceptability of anti-diabetic agents for Alzheimer's disease (AD) and mild cognitive impairment (MCI). Cochrane Library (CENTRAL), PubMed/MEDLINE, EMBASE and PsycINFO were searched from inception to January 15, 2018 for randomized controlled trials (RCTs) comparing anti-diabetic agents with placebo and/or another active anti-diabetic agent for the treatment of AD or MCI. Nineteen eligible studies (n = 4,855) evaluating the effects of six different anti-diabetic drugs (i...
May 23, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29790536/dna-interactions-of-non-chelating-tinidazole-based-coordination-compounds-and-their-structural-redox-and-cytotoxic-properties
#9
Rodrigo Castro-Ramírez, Naytzé Ortiz-Pastrana, Ana B Caballero, Matthew T Zimmerman, Bradley S Stadelman, Andrea A E Gaertner, Julia L Brumaghim, Luís Korrodi-Gregório, Ricardo Pérez-Tomás, Patrick Gamez, Norah Barba-Behrens
Novel tinidazole (tnz) coordination compounds of different geometries were synthesised, whose respective solid-state packing appears to be driven by inter- and intramolecular lone pairπ interactions. The copper(ii) compounds exhibit interesting redox properties originating from both the tnz and the metal ions. These complexes interact with DNA through two distinct ways, namely via electrostatic interactions or/and groove binding, and they can mediate the generation of ROS that damage the biomolecule. Cytotoxic studies revealed an interesting activity of the dinuclear compound [Cu(tnz)2(μ-Cl)Cl]2 7, which is further more efficient towards cancer cells, compared with normal cells...
May 23, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29790165/igg1-b-cell-immunity-predates-ige-responses-in-epicutaneous-sensitization-to-foods
#10
Rodrigo Jiménez-Saiz, Yosef Ellenbogen, Joshua Koenig, Melissa E Gordon, Tina D Walker, Domenico Rosace, Paul Spill, Kelly Bruton, Joshua Kong, Kristin Monteiro, Jianping Wen, Elaine I Tuomanen, Roland Kolbeck, Derek K Chu, Susan Waserman, Manel Jordana
BACKGROUND: The generation of IgE-mediated food allergy in humans is silent, and only diagnosed upon manifestation of clinical symptoms. While experimental models have been used to investigate some mechanisms of allergic sensitization, the generation of humoral immunity and memory remain to be elucidated. Here, we defined the evolution of allergen-specific B cell responses during epicutaneous sensitization to foods. METHODS: Wild-type and genetic knockout animals, and drug or antibody strategies for cell depletion and immunoglobulin signaling blockade were used to investigate epicutaneous sensitization and disease progression; we analyzed allergen-specific germinal centers and IgG1+ memory B cells by flow cytometry, evaluated humoral responses and determined clinical reactivity (anaphylaxis)...
May 22, 2018: Allergy
https://www.readbyqxmd.com/read/29789952/carotid-body-ablation-a-new-target-to-address-central-autonomic-dysfunction
#11
REVIEW
Rodrigo Iturriaga
PURPOSE OF REVIEW: An abnormal heightened carotid body (CB) chemoreflex, which produces autonomic dysfunction and sympathetic overactivation, is the common hallmark of obstructive sleep apnea (OSA), resistant hypertension, systolic heart failure (HF), and cardiometabolic diseases. Accordingly, it has been proposed that the elimination of the CB chemosensory input to the brainstem may reduce the autonomic and cardiorespiratory alterations in sympathetic-associated diseases in humans. RECENT FINDINGS: A growing body of evidence obtained in preclinical animal models support that an enhanced CB discharge produces sympathetic hyperactivity, baroreflex sensitivity and heart rate variability impairment, breathing instability, hypertension, and insulin resistance...
May 22, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29789795/clinical-and-experimental-evidences-of-hydrogen-sulfide-involvement-in-lead-induced-hypertension
#12
José Sérgio Possomato-Vieira, Victor Hugo Gonçalves-Rizzi, Regina Aparecida do Nascimento, Rodrigo Roldão Wandekin, Mayara Caldeira-Dias, Jessica Sabbatine Chimini, Maria Luiza Santos da Silva, Carlos A Dias-Junior
Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H2 S) have been reported previously. However, no studies examined involvement of H2 S in Pb-induced hypertension. We found increases in diastolic blood pressure and mean blood pressure in Pb-intoxicated humans followed by diminished H2 S plasmatic levels. In order to expand our findings, male Wistar rats were divided into four groups: Saline, Pb, NaHS, and Pb + NaHS. Pb-intoxicated animals received intraperitoneally (i...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789766/salvage-high-dose-rate-brachytherapy-for-prostate-cancer-persistence-after-brachytherapy-repeated-use-of-a-polyethylene-glycol-hydrogel-spacer
#13
Rodrigo Hepp, Thilo Eggert, Georg Schabl, Lars Herberholz, Tim Petry, Razvan Galalae
Purpose: The aim of this study is to determine if a repeated hydrogel injection in a previously irradiated patient prior to salvage high-dose-rate brachytherapy (HDR-BT) is feasible. Material and methods: A 61-year-old man with an organ confined (cT1c cN0 cM0, Gleason score 3 + 3 = 6, initial prostate-specific antigen [PSA] 7.9 ng/ml) prostate cancer was previously treated with HDR-BT (3 fractions of 11.5 Gy every 2nd week) after hydrogel injection to reduce the rectal dose...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789691/performance-of-nosas-score-versus-berlin-questionnaire-for-screening-obstructive-sleep-apnoea-in-patients-with-resistant-hypertension
#14
Sara Q C Giampá, Rodrigo P Pedrosa, Carolina C Gonzaga, Adriana Bertolami, Celso Amodeo, Sofia F Furlan, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Luciano F Drager
Obstructive sleep apnoea (OSA) is the main secondary form associated with resistant hypertension (RH), but it is largely underdiagnosed and consequently undertreated in clinical practice. The Berlin questionnaire (BQ) is a useful tool among general population, but seems to not perform well among patients with RH. Recently, NoSAS score was validated in a large population, however, has not been tested in the cardiovascular scenario. Thus, we aimed to compare BQ versus the NoSAS score as screening tools for OSA in RH...
May 23, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29789458/flying-real-time-network-to-coordinate-disaster-relief-activities-in-urban-areas-%C3%A2
#15
Matias Micheletto, Vinicius Petrucci, Rodrigo Santos, Javier Orozco, Daniel Mosse, Sergio F Ochoa, Roc Meseguer
While there have been important advances within wireless communication technology, the provision of communication support during disaster relief activities remains an open issue. The literature in disaster research reports several major restrictions to conducting first response activities in urban areas, given the limitations of telephone networks and radio systems to provide digital communication in the field. In search-and-rescue operations, the communication requirements are increased, since the first responders need to rely on real-time and reliable communication to perform their activities and coordinate their efforts with other teams...
May 22, 2018: Sensors
https://www.readbyqxmd.com/read/29789313/blast-xyplot-viewer-a-tool-for-performing-blast-in-whole-genome-sequenced-bacteria-archaea-and-visualize-whole-results-simultaneously
#16
Yagul Pedraza-Pérez, Rodrigo Alberto Cuevas-Vede, Ángel Bernardo Canto-Gómez, Liliana López-Pliego, Rosa María Gutiérrez-Ríos, Ismael Hernández-Lucas, Gustavo Rubín-Linares, Ygnacio Martínez-Laguna, Jesús Francisco López-Olguín, Luis Ernesto Fuentes-Ramírez
One of the most commonly used tools to compare protein or DNA sequences against databases is BLAST. We introduce a web tool that allows the performance of BLAST-searches of protein/DNA sequences in whole-genome sequenced bacteria/archaea, and displays a large amount of BLAST-results simultaneously. The circular bacterial replicons are projected as horizontal lines with fixed length of 360, representing the degrees of a circle. A coordinate system is created with length of the replicon along the x -axis and the number of replicon used on the y -axis...
May 22, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29789269/anterior-cingulate-cortex-glutamatergic-metabolites-and-mood-stabilizers-in-euthymic-bipolar-i-disorder-patients-a-proton-magnetic-resonance-spectroscopy-study
#17
Marcio Gerhardt Soeiro-de-Souza, Maria Concepcion Garcia Otaduy, Rodrigo Machado-Vieira, Ricardo Alberto Moreno, Fabiano G Nery, Claudia Leite, Beny Lafer
BACKGROUND: Bipolar disorder is a chronic and recurrent illness characterized by depressive and manic episodes. Proton magnetic resonance spectroscopy (1 H-MRS) studies have demonstrated glutamate (Glu) system abnormalities in BD, but it is unclear how Glu varies among mood states and how medications modulate it. The objective of this study was to investigate the influence of mood stabilizers on anterior cingulate cortex Glu levels using 1 H-MRS during euthymia. METHODS: One hundred twenty-eight bipolar I disorder (BDI) euthymic subjects and 80 healthy control subjects underwent 3T brain 1 H-MRS imaging examination including acquisition of an anterior cingulate cortex single voxel (8 cm3 ) 1 H-MRS, based on a point resolved spectroscopy (PRESS) sequence with an echo time of 80 ms and a repetition time of 1500 ms (BIPUSP MRS study)...
March 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29788508/governments-must-catch-up-with-workplace-non-communicable-disease-prevention
#18
Rodrigo Rodriguez-Fernandez
No abstract text is available yet for this article.
May 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29788238/atypical-bypass-tracts-can-they-be-recognized-during-sinus-rhythm
#19
José Nunes de Alencar Neto, Saulo Rodrigo Ramalho de Moraes, Eduardo Back Sternick, Hein J J Wellens
Atypical bypass tracts or variants of ventricular pre-excitation are rare anatomic structures often with rate-dependent slowing in conduction, called decremental conduction. During sinus rhythm, electrocardiographic recognition of those structures may be difficult because unlike in the Wolff-Parkinson-White syndrome where usually overt ventricular pre-excitation is present, the electrocardiogram (ECG) often shows a subtle pre-excitation pattern because of less contribution to ventricular activation over the slow and decrementally conducting bypass...
May 16, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29787874/ancient-observation-of-spinal-cord-injury-the-case-of-the-assiryan-lion
#20
REVIEW
Gustavo J Luvizutto, Emerson G Siqueira, Pedro Tadao Hamamoto Filho, Viviane F Zétola, Marcos C Lange, Hélio A Theive, Luiz A Resende, Rodrigo Bazan
The description of paraplegia is considered a milestone in the history of neurology. The Egyptians provided excellent descriptions of spinal cord injuries, the Bible has several references to paraplegia, and, more recently, the pioneers of neurology described the classic syndromes related to spinal injuries and paraplegia. Here, we describe an ancient observation by the Assyrian people of paraplegia in an animal. In ancient Assyria, lion hunting was a ritualized activity conducted for political and religious purposes...
May 19, 2018: World Neurosurgery
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