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https://www.readbyqxmd.com/read/28325584/development-of-a-surrogate-model-based-on-patient-weight-bone-mass-and-geometry-to-predict-femoral-neck-strains-and-fracture-loads
#1
Mark Taylor, Egon Perilli, Saulo Martelli
Osteoporosis and related bone fractures are an increasing global burden in our ageing society. Areal bone mineral density assessed through dual energy X-ray absorptiometry (DEXA), the clinically accepted and most used method, is not sufficient to assess fracture risk individually. Finite element (FE) modelling has shown improvements in prediction of fracture risk, better than aBMD from DEXA, but is not practical for widespread clinical use. The aim of this study was to develop an adaptive neural network (ANN)-based surrogate model to predict femoral neck strains and fracture loads obtained from a previously developed population-based FE model...
February 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28320909/theoretical-and-computational-studies-of-non-equilibrium-and-non-statistical-dynamics-in-the-gas-phase-in-the-condensed-phase-and-at-interfaces
#2
Riccardo Spezia, Emilio Martínez-Nuñez, Saulo Vazquez, William L Hase
In this Introduction, we show the basic problems of non-statistical and non-equilibrium phenomena related to the papers collected in this themed issue. Over the past few years, significant advances in both computing power and development of theories have allowed the study of larger systems, increasing the time length of simulations and improving the quality of potential energy surfaces. In particular, the possibility of using quantum chemistry to calculate energies and forces 'on the fly' has paved the way to directly study chemical reactions...
April 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28318536/chromobacterium-violaceum-infection-in-a-horse
#3
Márcia Elisa Hammerschmitt, Veronica Machado Rolim, Gustavo Geraldo Medina Snel, Franciele Maboni Siqueira, David Driemeier, Saulo Petinatti Pavarini
Chromobacterium violaceum is an opportunistic pathogen of mammals that produces characteristic violet pigment in bacterial culture. We report pneumonia and septicaemia caused by C. violaceum in a horse. Necropsy examination was performed on a 3-year-old Quarter Horse stallion with a history of recurrent episodes of pneumonia, fever, dyspnoea and sanguineous nasal discharge. The lungs were not collapsed, but they contained dark red foci mixed with white areas, and multiple nodules of firm consistency. Within the liver and kidney there were randomly distributed, multifocal, white pinpoint lesions (0...
March 16, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28301790/human-papillomavirus-vaccination-and-genital-warts-in-young-indigenous-australians-national-sentinel-surveillance-data
#4
Hammad Ali, Hamish McManus, Catherine C O'Connor, Denton Callander, Marlene Kong, Simon Graham, Dina Saulo, Christopher K Fairley, David G Regan, Andrew Grulich, Nicola Low, Rebecca J Guy, Basil Donovan
OBJECTIVES: To examine the impact of the national human papillomavirus (HPV) vaccination program (available to girls and women [12-26 years] since 2007 and to boys [12-15 years] since 2013) on the number of diagnoses of genital warts in Australian Aboriginal and Torres Strait Islander (Indigenous) people. DESIGN, SETTING, PARTICIPANTS: Analysis of routinely collected data from patients attending 39 sexual health clinics (SHCs) in the Genital Warts Surveillance Network for the first time...
March 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28286381/rotary-instrument-or-piezoelectric-for-the-removal-of-third-molars-a-meta-analysis
#5
REVIEW
Rafael Alvim Magesty, Endi Lanza Galvão, Carolina de Castro Martins, Cássio Roberto Rocha Dos Santos, Saulo Gabriel Moreira Falci
AIM: The aim of this systematic review and meta-analysis was to compare, in the lower third molar surgery, the osteotomy techniques with rotary instruments and piezoelectric motors. METHODS: An electronic search was conducted using the following databases: Pubmed, Web of Science, and the Cochrane Oral Health Group Trials Register. Inclusion criteria were: studies in humans, randomized or nonrandomized, comparing the extraction of third molars that required osteotomy and/or odontosection with rotary instrument and osteotomy and/or odontosection with piezoelectric motor assistance...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28253179/prevalence-of-pathologic-findings-in-the-floor-of-the-maxillary-sinuses-on-cone-beam-computed-tomography-images
#6
Aline Fernanda Almeida Da Silva, Gontran Rocha Torres Fróes, Wilton Mitsunari Takeshita, Juliana Batista Melo Da Fonte, Maria Fátima Batista De Melo, Saulo Leonardo Sousa Melo
This study evaluated pathologic findings in the floor of the maxillary sinuses on cone beam computed tomography (CBCT) images. CBCT scans of 500 subjects, mainly taken for dental implant planning, were evaluated. The pathologic findings in the 1000 maxillary sinuses (left and right) were categorized into 4 classes: mucosal thickening, mucous retention pseudocyst, partial opacification, and total opacification. Pathologic alterations were equally found in both sinuses (48.2% of right maxillary sinuses and 48...
March 2017: General Dentistry
https://www.readbyqxmd.com/read/28239353/transient-receptor-potential-ankyrin-1-channel-expression-on-peripheral-blood-leukocytes-from-rheumatoid-arthritic-patients-and-correlation-with-pain-and-disability
#7
Ione Pereira, Saulo J F Mendes, Domingos M S Pereira, Thayanne F Muniz, Valderlane L P Colares, Cinara R A V Monteiro, Mahiba M R de S Martins, Marcos A G Grisotto, Valério Monteiro-Neto, Sílvio G Monteiro, João B Calixto, Susan D Brain, Elizabeth S Fernandes
Patients with rheumatoid arthritis (RA) suffer from pain and joint disability. The transient receptor potential ankyrin 1 (TRPA1) channel expressed on sensory neurones and non-neuronal cells mediates pain transduction and inflammation and it has been implicated in RA. However, there is little information on the contribution of TRPA1 for human disease. Here, we investigated the expression of TRPA1 on peripheral blood leukocytes and the circulating levels of its endogenous activators 4-hydroxynonenal (4-HNE) and hydrogen peroxide (H2O2) in RA patients treated or not with the anti-rheumatic leflunomide (LFN) or the anti-TNFα adalimumab (ADA)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28238773/inhibition-of-the-tetk-efflux-pump-by-the-essential-oil-of-chenopodium-ambrosioides-l-and-%C3%AE-terpinene-against-staphylococcus-aureus-is-58
#8
Paulo W Limaverde, Fábia F Campina, Francisco A B da Cunha, Francidalva D Crispim, Fernando G Figueredo, Luciene F Lima, Cícera Datiane de M Oliveira-Tintino, Yedda M L S de Matos, Maria Flaviana B Morais-Braga, Irwin R A Menezes, Valdir Q Balbino, Henrique D M Coutinho, José P Siqueira-Júnior, Jackson R G S Almeida, Saulo R Tintino
The use of natural products is crucial to suppress the development of these micro-organisms and to reduce the concentration necessary to inhibit these microrganisms, reducing the toxicity risks also. In this study, the essential oil from Chenopodium ambrosioides Leaves and its main constituent α-Terpinene were used in the antibacterial and potentiating activity of antibiotics and ethidium bromide assays, against the bacterial strains Staphylococcus aureus IS-58, carriers of efflux pumps. The Minimum Inhibitory Concentration (MIC) was determined using a microdilution method...
February 23, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28230389/from-classicism-and-idealism-to-scientific-naturalism-titchener-s-oxford-years-and-their-impact-upon-his-early-intellectual-development
#9
Saulo de Freitas Araujo, Cintia Fernandes Marcellos
Edward Titchener (1867-1927) is one of the most prominent figures in the history of American psychology from the early 20th century. Accordingly, his psychological system-structuralism-has received due attention in the secondary literature. However, a closer look at traditional interpretations of the development of Titchener's ideas reveals a series of missing elements, such as his early studies before going to Leipzig. The central goal of this article is to present the main elements of Titchener's intellectual education in Oxford, thereby showing the influence of the British tradition of the 19th century upon his early intellectual development...
February 23, 2017: History of Psychology
https://www.readbyqxmd.com/read/28219631/condyle-excursion-angle-articular-eminence-inclination-and-temporomandibular-joint-morphologic-relations-with-disc-displacement
#10
Katharina Alves Rabelo, Saulo Leonardo Sousa Melo, Marianna Guanaes Gomes Torres, Paulo Sérgio F Campos, Patrícia Meira Bento, Daniela Pita de Melo
PURPOSE: The aim of this study was to evaluate the relations of the condyle excursion angle (CEA) and the morphology and morphometry of the articular eminence to disc displacement (DD) using magnetic resonance imaging (MRI) of symptomatic patients. MATERIALS AND METHODS: MRIs of 199 temporomandibular joints (TMJs) were evaluated. Qualitative and quantitative morphologic analyses were performed with tools available in PACS 11.0 (Carestream Health, Inc, Rochester, NY)...
January 29, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28216018/prospective-randomised-controlled-study-evaluating-early-modification-of-oral-microbiota-following-admission-to-the-intensive-care-unit-and-oral-hygiene-with-chlorhexidine
#11
Felipe Francisco Tuon, Oleg Gavrilko, Saulo de Almeida, Eigi Ricardo Sumi, Thiago Alberto, Jaime Luis Rocha, Edvaldo Antonio Rosa
OBJECTIVES: Chlorhexidine (CHX) is the most commonly used oral hygiene product for the prevention of ventilator-associated pneumonia (VAP) in patients undergoing mechanical ventilation (MV). The change in dental plaque (DP) microbiota following CHX use in patients under MV has not been described previously. The aim of this study was to evaluate the incidence of pathogenic bacteria associated with VAP and the coverage of DP within the oral cavity in patients administered CHX. METHODS: This was a prospective, randomised, controlled, double-blind study in patients (n=16) under MV who were mouth-rinsed with either CHX or placebo...
February 18, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28215783/synthesis-and-biological-evaluation-of-potential-inhibitors-of-the-cysteine-proteases-cruzain-and-rhodesain-designed-by-molecular-simplification
#12
Saulo Fehelberg Pinto Braga, Luan Carvalho Martins, Elany Barbosa da Silva, Policarpo Ademar Sales Júnior, Silvane Maria Fonseca Murta, Alvaro José Romanha, Wai Tuck Soh, Hans Brandstetter, Rafaela Salgado Ferreira, Renata Barbosa de Oliveira
Analogues of 8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]indol-4-amine 1, a known cruzain inhibitor, were synthesized using a molecular simplification strategy. Five series of analogues were obtained: indole, pyrimidine, quinoline, aniline and pyrrole derivatives. The activity of the compounds was evaluated against the enzymes cruzain and rhodesain as well as against Trypanosoma cruzi amastigote and trypomastigote forms. The 4-aminoquinoline derivatives showed promising activity against both enzymes, with IC50 values ranging from 15 to 125µM...
February 9, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28214274/intra-abdominal-fungal-pseudomycetoma-in-two-cats
#13
Matheus V Bianchi, Cláudio J M Laisse, Thainã P Vargas, Flademir Wouters, Fabiana M Boabaid, Saulo P Pavarini, Laerte Ferreiro, David Driemeier
BACKGROUND: Pseudomycetomas are deep cutaneous to subcutaneous lesions caused by Microsporum canis mainly described in Persian cats, with few reports of intra-abdominal location. This report describes the clinical signs and lesions of intra-abdominal pseudomycetomas caused by M. canis in two Persian cats. CASE REPORT: Two Persian cats with a history of previous laparotomy (ovariohysterectomy and nephrostomy) and fecal impaction were examined. Cat #1 was euthanized and subjected to necropsy, histopathology and mycological evaluation...
February 14, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28171606/comparing-co-evolution-methods-and-their-application-to-template-free-protein-structure-prediction
#14
Saulo Henrique Pires de Oliveira, Jiye Shi, Charlotte M Deane
No abstract text is available yet for this article.
February 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28168080/the-femoral-neck-mechanoresponse-to-hip-extensors-exercise-a-case-study
#15
Saulo Martelli, Hossein Mokhtarzadeh, Peter Pivonka, Peter R Ebeling
Physical activity is recommended to prevent age-related bone loss. However, the proximal femur mechanoresponse is variable, possibly because of a muscle-dependant mechanoresponse. We compared the proximal femur response with the femoral strain pattern generated by the hip extensor muscles. A healthy participant underwent a six-month unilateral training of the hip extensor muscles using a resistance weight regularly adjusted to the 80% of the one-repetition maximum weight. DXA-based measurements of the areal Bone Mineral Density (aBMD) in the exercise leg were adjusted for changes in the control leg...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28159993/evaluation-of-8-hydroxyquinoline-derivatives-as-hits-for-antifungal-drug-design
#16
Bruna Pippi, Paula Reginatto, Gabriella da Rosa Monte Machado, Vanessa Zafaneli Bergamo, Daiane Flores Dalla Lana, Mario Lettieri Teixeira, Lucas Lopardi Franco, Ricardo José Alves, Saulo Fernandes Andrade, Alexandre Meneghello Fuentefria
No abstract text is available yet for this article.
February 4, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28153940/heart-rate-kinetics-during-exercise-in-patients-with-subclinical-hypothyroidism
#17
Saulo Peters Almas, Francisco Werneck, Emerson Coelho, Patrícia Teixeira, Mario Vaisman
Studies suggest that patients with subclinical hypothyroidism (SH) have sympathovagal imbalance, which could lead to a slower heart rate (HR) response in the transition from rest to exercise. Thus, the objective of this study was to investigate the behavior of the HR kinetics in patients with SH during the transition from rest to exercise. The study included 18 SH women (TSH = 6.95 ± 2.94 μIU/mL and FT4 = 0.96 ± 0.15 ng/dl) and 17 euthyroid women (TSH = 2.28 ± 0.84 μIU/mL and FT4 = 0.98 ± 0.07 ng/dl)...
February 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28149471/bond-strength-of-adhesive-resin-cement-with-different-adhesive-systems
#18
Fabrizio Lorenzoni E Silva, Saulo Pamato, Milton-Carlos Kuga, Marcus-Vinicius-Reis Só, Jefferson-Ricardo Pereira
BACKGROUND: To assess the immediate bond strength of a dual-cure adhesive resin cement to the hybridized dentin with different bonding systems. MATERIAL AND METHODS: Fifty-six healthy human molars were randomly divided into 7 groups (n=8). After 3 longitudinal sections, the central cuts were included in PVC matrix and were submitted to dentin hybridization according to the groups: G1 - etch & rinse system with 3-step (Apder™ Scotchbond™ Multi-Purpose, 3M ESPE), G2 - etch & rinse system with 3-step (Optibond™ FL, Kerr), G3 - etch & rinse system with 3-step (All-Bond 3®, Bisco), G4 - etch & rinse simplified system (Adper™ Single Bond 2, 3M ESPE), G5 - self-etching system with one step (Bond Force, Tokuyama), G6 - universal system in moist dentin (Single Bond Universal, 3M ESPE), G7 - universal system in dry dentin (Single Bond Universal, 3M ESPE)...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28146095/synthesis%C3%A2-of%C3%A2-16%C3%A2-new%C3%A2-hybrids%C3%A2-from%C3%A2-tetrahydropyrans-derivatives%C3%A2-and%C3%A2-morita-baylis-hillman%C3%A2-adducts-%C3%A2-in-vitro%C3%A2-screening%C3%A2-against%C3%A2-leishmania%C3%A2-donovani
#19
Suervy Canuto de Oliveira Sousa, Juliana da Câmara Rocha, Tatjana de Souza Lima Keesen, Everton da Paz Silva, Priscilla Anne Castro de Assis, João Paulo Gomes de Oliveira, Saulo Luís Capim, Francisco José Seixas Xavier, Bruno Guimarães Marinho, Fábio Pedrosa Lins Silva, Claudio Gabriel Lima-Junior, Mário Luiz Araújo de Almeida Vasconcellos
Leishmaniases are a group of neglected tropical diseases (NTDs) caused by protozoan parasites from >20 Leishmania species. Visceral leishmaniasis (VL), also known as kala-aza, is the most severe form of leishmaniasis, usually fatal in the absence of treatment in 95% of cases. The Morita-Baylis-Hillman adducts (MBHAs) are being explored as drug candidates against several diseases, one of them being leishmaniasis. We present here the design, synthesis and in vitro screening against Leishmania donovani of sixteen new molecular hybrids from analgesic/antiinflammatory tetrahydropyrans derivatives and Morita-Baylis-Hillman adducts...
January 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28137401/secondary-hyperalgesia-occurs-regardless-of-unilateral-or-bilateral-knee-osteoarthritis-involvement-in-individuals-with-mild-or-moderate-level
#20
Vanessa Martins Pereira Silva Moreira, Saulo Delfino Barboza, Juliana Borges Oliveira, Janser Moura Pereira, Valdeci Carlos Dionisio
BACKGROUND: Secondary hyperalgesia in individuals with less severe levels of knee osteoarthritis remains unclear. The objective of this study was to measure the pressure pain threshold of individuals with mild or moderate knee osteoarthritis and compare with no osteoarthritis. METHODS: Ten healthy controls and 30 individuals with mild or moderate knee osteoarthritis divided into two groups (unilateral and bilateral involvement) were included. Dermatomes in lumbar levels (L1, L2, L3, L4 and L5) and sacral level (S1 and S2), myotomes (vastus medialis, vastus lateralis, rectus femoris, adductor longus, tibialis anterior, peroneus longus, iliacus, quadratus lumborum, and popliteus muscles), and sclerotomes in lumbar levels (L1-L2, L2-L3, L3-L4, L4-L5 supraspinous ligaments), over the L5-S1 and S1-S2 sacral areas, pes anserinus bursae, and at the patellar tendon pressure pain threshold were assessed and compared between individuals with and without knee osteoarthritis...
January 2017: Revista Brasileira de Reumatologia
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