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Postactivation potentiation

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https://www.readbyqxmd.com/read/28750279/tnf-receptor-superfamily-agonists-as-molecular-adjuvants-for-cancer-vaccines
#1
REVIEW
Timothy Nj Bullock
Cancer vaccines have offered unrequited hope as a mechanism for rapidly and potently eliciting a patient's immune system to counter tumors. Initial results from preclinical mouse models have not translated to substantial benefit to patients, suggesting that either the targets or the vaccination approach were inadequate. Recent innovations in antigen identification have spiked renewed interest vaccination technologies. This has coincided with a detailed molecular understanding of the coordinated steps in postactivation support of T cell proliferation, differentiation and survival, leading to the development of novel targets and combinations that are substantially more effective than first and second generation cancer vaccines in preclinical models...
July 24, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28700513/sled-towing-acutely-decreases-acceleration-sprint-time
#2
Megan A Wong, Ian J Dobbs, Casey M Watkins, Saldiam R Barillas, A Lin, David C Archer, Robert G Lockie, Jared W Coburn, Lee E Brown
Sled towing is a common form of overload training in sports to develop muscular strength for sprinting. This type of training leads to acute and chronic outcomes. Acute training potentially leads to postactivation potentiation (PAP), which is when subsequent muscle performance is enhanced following a preload stimulus. The purpose of this study was to determine differences between rest intervals following sled towing on acute sprint speed. Twenty healthy recreationally trained males (age= 22.3 ± 2.4yrs, height= 176...
July 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28663252/glucose-transporter-3-potentiates-degranulation-and-is-required-for-platelet-activation
#3
Trevor P Fidler, Elizabeth A Middleton, Jesse W Rowley, Luc H Boudreau, Robert A Campbell, Rhonda Souvenir, Trevor Funari, Nicolas Tessandier, Eric Boilard, Andrew S Weyrich, E Dale Abel
OBJECTIVE: On activation, platelets increase glucose uptake, glycolysis, and glucose oxidation and consume stored glycogen. This correlation between glucose metabolism and platelet function is not well understood and even less is known about the role of glucose metabolism on platelet function in vivo. For glucose to enter a cell, it must be transported through glucose transporters. Here we evaluate the contribution of GLUT3 (glucose transporter 3) to platelet function to better understand glucose metabolism in platelets...
September 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28538313/the-effects-of-accentuated-eccentric-loading-on-the-drop-jump-exercise-and-the-subsequent-postactivation-potentiation-response
#4
Lee A Bridgeman, Michael R McGuigan, Nicholas D Gill, Deborah K Dulson
The aims of this study were (a) to investigate the acute effects of different drop jump (DJ) accentuated eccentric loading (AEL) protocols and (b) to investigate the effect of these AEL DJ protocols on subsequent countermovement jump (CMJ) performance. The subjects were 12 strength-trained athletes; initially, baseline CMJ performance was assessed and individual optimal DJ drop height identified. In subsequent weeks, subjects completed 1 set of 5 DJs with no additional load or an AEL of 10, 20, or 30% of their individual body mass (BM) using dumbbells to provide the extra load...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28503527/postactivation-potentiation-in-elite-young-soccer-players
#5
Adriano Titton, Emerson Franchini
The aim of this study was to investigate the acute effects of 16 different combinations to cause the postactivation potentiation (PAP) in elite young soccer players. Squat exercise in 4 different intensities (40%, 60%, 80%, and 100% one-repetition maximum [1RM]) was performed and its effects were evaluated in the performance of countermovement jump (CMJ), after 4 different recovery times (1, 3, 5, and 10 min). For this purpose, 25 young soccer players, underwent five experimental sessions. At the first session the control to determine 1RM in half-squat was carried out...
April 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28455452/corticospinal-excitability-to-the-biceps-brachii-and-its-relationship-to-postactivation-potentiation-of-the-elbow-flexors
#6
Brandon W Collins, Laura H Gale, Natasha C M Buckle, Duane C Button
We examined the effects of a submaximal voluntary elbow flexor contraction protocol on measures of corticospinal excitability and postactivation potentiation of evoked muscle forces and if these measures were state-dependent (rest vs. voluntary muscle contraction). Participants completed four experimental sessions where they rested or performed a 5% maximum voluntary contraction (MVC) of the elbow flexors prior to, immediately, and 5 min following a submaximal contraction protocol. During rest or 5% MVC, transcranial magnetic stimulation, transmastoid electrical stimulation, electrical stimulation of biceps brachii motor point and Erb's point were elicited to induce motor-evoked potentials (MEPs), cervicomedullary MEPs (CMEPs), potentiated twitch (PT) force, and maximal muscle compound action potential (Mmax), respectively prior to, immediately, and 5 min postcontraction protocol...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28290716/cycling-vs-uphill-walking-impact-on-locomotor-muscle-fatigue-and-running-exercise
#7
Benjamin Pageaux, Jean Theurel, Romuald Leper
PURPOSE: To describe the effects of uphill walking versus cycling exercises on knee extensors (KE) neuromuscular properties and subsequent running exercise. METHODS: Nine athletes performed four different sessions (one familiarization and three experimental sessions, visit 2 to 4). Visit 2 (cycling + 10 km condition) consisted of the completion of 1-h cycling followed by a 10 km running time trial. Visit 3 consisted of the completion of 1-h uphill walking followed by a 10 km running exercise (RE)...
March 14, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28166184/postactivation-potentiation-and-change-of-direction-speed-in-elite-academy-rugby-players
#8
Chris Bishop, Anthony N Turner, Jon Cree, Sean Maloney, James Marshall, Paul Jarvis
This study investigated the effect of preceding pro-agility sprints with maximal isometric squats to determine if postactivation potentiation (PAP) could be harnessed in change of direction speed. Sixteen elite under-17 rugby union players (age: 16 ± 0.41yrs; body mass: 88.7 ± 12.1kg, height: 1.83 ± 0.07m) from an Aviva Premiership rugby club were tested. Subjects performed a change of direction specific warm-up, followed by two baseline pro-agility tests. After 10 minutes recovery, 3 x 3-second maximal isometric squats with a 2 minute recovery between sets were completed as a conditioning activity (CA) on a force plate where peak force and mean rate of force development over 300 milliseconds were measured...
February 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27967282/whole-body-vibration-increases-subsequent-sprint-performance-in-well-trained-cyclists
#9
Bent R Rønnestad, Gunnar Slettaløkken Falch, Stian Ellefsen
PURPOSE: Postactivation potentiation (PAP) exercise with added whole-body vibration (WBV) has been suggested as a potential way to acutely improve sprint performance. In cycling, there are many competitions and situations where sprinting abilities are important. In the present study we investigated the effect of adding WBV to warm-up procedures on subsequent cycle sprint performance. METHODS: Eleven well-trained cyclists participated in the study. All cyclists performed a familiarization session before two separate test sessions in randomized order...
December 14, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27935646/postactivation-potentiation-can-counteract-declines-in-force-and-power-that-occur-after-stretching
#10
J Kümmel, A Kramer, N J Cronin, M Gruber
Stretching can decrease a muscle's maximal force, whereas short but intense muscle contractions can increase it. We hypothesized that when combined, postactivation potentiation induced by reactive jumps would counteract stretch-induced decrements in drop jump (DJ) performance. Moreover, we measured changes in muscle twitch forces and ankle joint stiffness (KAnkle ) to examine underlying mechanisms. Twenty subjects completed three DJs and 10 electrically evoked muscle twitches of the triceps surae subsequent to four different conditioning activities and control...
December 9, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27901341/the-efficacy-and-characteristics-of-warm-up-and-re-warm-up-practices-in-soccer-players-a-systematic-review
#11
Amri Hammami, James Zois, Maamer Slimani, Mark Russel, Ezdine Bouhlel
INTRODUCTION: This review aimed (i) to evaluate the current research that examines the efficacy of warm-up (WU) and re-warm-up (RWU) on physical performance, and (ii) to highlight the WU and RWU characteristics that optimise subsequent performance in soccer players. EVIDENCE ACQUISITION: A computerized search was performed in the PubMed, ScienceDirect and Google Scholar (from 1995 to December 2015) for English-language, peer- reviewed investigations using the terms "soccer" OR "football" AND "warm-up" OR "stretching" OR "post-activation potentiation" OR "pre-activity" OR "re-warm-up" AND "performance" OR "jump" OR "sprint" OR "running"...
November 30, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27741057/influence-of-rest-intervals-after-assisted-sprinting-on-bodyweight-sprint-times-in-female-collegiate-soccer-players
#12
Austyn L Nealer, Dustin D Dunnick, Kylie K Malyszek, Megan A Wong, Pablo B Costa, Jared W Coburn, Lee E Brown
Nealer, AL, Dunnick, DD, Malyszek, KK, Wong, MA, Costa, PB, Coburn, JW, and Brown, LE. Influence of rest intervals after assisted sprinting on bodyweight sprint times in female collegiate soccer players. J Strength Cond Res 31(1): 88-94, 2017-Speed is a crucial element an athlete must possess to be successful. In soccer, the ability to accelerate faster than your opponent can result in being first to reach a ball on a breakaway or stopping a counter attack. A unique way to train explosive movements is to evoke postactivation potentiation (PAP) in the working muscles...
January 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27736266/effects-of-plyometric-versus-concentric-and-eccentric-conditioning-contractions-on-upper-body-postactivation-potentiation
#13
Gert Ulrich, Mario Parstorfer
PURPOSE: There are limited data on postactivation potentiation's (PAP) effects after plyometric conditioning contractions (CCs), especially in the upper body. This study compared plyometric CCs with concentric-eccentric and eccentric CCs aiming to improve upper-body power performance due to a PAP effect. METHODS: Sixteen resistance-trained males completed 3 experimental trials in a randomized order that comprised either a plyometric (PLY), a concentric-eccentric (CON), or an eccentric-only (ECC) CC...
July 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27669181/the-effects-of-accentuated-eccentric-loading-on-the-drop-jump-exercise-and-the-subsequent-postactivation-potentiation-response
#14
Lee A Bridgeman, Michael R McGuigan, Nicholas D Gill, Deborah Dulson
The aims of this study were to (A) investigate the acute effects of different drop jump (DJ) accentuated eccentric loading (AEL) protocols and (B) to investigate the effect of these AEL DJ protocols on subsequent countermovement jump (CMJ) performance. The subjects were 12 strength-trained athletes, initially, baseline CMJ performance was assessed and individual optimal DJ drop height identified. In subsequent weeks subjects completed 1 set of 5 DJ's with no additional load or an AEL of 10, 20 or 30% of their individual body mass (BM) utilising dumbbells to provide the extra load...
September 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27447016/adding-whole-body-vibration-to-preconditioning-exercise-increases-subsequent-on-ice-sprint-performance-in-ice-hockey-players
#15
Bent R Rønnestad, Gunnar Slettaløkken, Stian Ellefsen
The phenomenon postactivation potentiation can possibly be used to acutely improve sprint performance. The purpose of this study was to investigate the effect of body-loaded half-squats with added whole body vibration (WBV) on subsequent 20 m on-ice sprint performance. Fifteen male ice-hockey players performed 4 test sessions on separate days and in a randomized order. Two of this test sessions were with WBV and 2 were with noWBV and the best sprint time was used to determine effectiveness. Each test session included preconditioning 30 seconds half-squat exercise, 2 of which were supplemented with 50 Hz WBV at a amplitude of 3 mm...
April 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27361832/comparison-of-hex-bar-deadlift-vs-back-squat-postactivation-potentiation-on-vertical-jump-takeoff-velocity-3263-board-328-june-3-3-30-pm-5-00-pm
#16
Cameron N Munger, Whitney D Leyva, David C Archer, Andrew J Galpin, Jared W Coburn, Lee E Brown
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27256788/postactivation-potentiation-of-dynamic-conditioning-contractions-on-rowing-sprint-performance
#17
Kenji Doma, Wade H Sinclair, Sarah R Hervert, Anthony S Leicht
OBJECTIVES: This study examined the post-activation potentiation effects of maximal dynamic contractions and gender on rowing sprint ability. DESIGN: Repeated measures. METHODS: Thirty-four male (n=17) and female (n=17) university students with experience in rowing took part in this study conducted across three weeks. Following familiarisation of the 10-second maximal rowing performance test on a rowing ergometer during Week 1, participants were randomly allocated to either complete a control or experimental session during Week 2 and 3...
November 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27182310/exercise-bouts-at-three-different-intensities-fail-to-potentiate-concentric-power
#18
Chad A Cabrera, Jacobo Morales, Felicia Greer, Robert W Pettitt
Postactivation potentiation (PAP) has been hypothesized previously to occur during voluntary, concentric actions. We tested the hypothesis that one of at least three different intensities of conditioning exercises would evoke potentiation of power during the concentric, bench press throw (BPT). Twelve men (age = 22.9 ± 2.7 years, bench press 1 repetition maximum (1RM) = 1.20 ± 0.12 kg·kg(-1) body weight) completed five isotonic conditioning presses at ~55, 70, and 86% 1RM, in counterbalanced order, and on separate days...
2009: International Journal of Exercise Science
https://www.readbyqxmd.com/read/26988769/relationships-between-maximal-strength-muscle-size-and-myosin-heavy-chain-isoform-composition-and-postactivation-potentiation
#19
Laurent B Seitz, Gabriel S Trajano, G Gregory Haff, Charles C L S Dumke, James J Tufano, Anthony J Blazevich
The purpose of this study was to examine the relationships between maximal voluntary postactivation potentiation (PAP) and maximal knee extensor torque, quadriceps cross-sectional area (CSA) and volume, and type II myosin heavy chain (MHC) isoform percentage in human skeletal muscle. Thirteen resistance-trained men completed a test protocol consisting of 2 isokinetic knee extensions at 180°·s(-)(1) performed before and 1, 4, 7, and 10 min after the completion of 4 maximal knee extensions at 60°·s(-)(1) (i...
May 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/26959056/the-effects-of-creatine-supplementation-on-explosive-performance-and-optimal-individual-postactivation-potentiation-time
#20
RANDOMIZED CONTROLLED TRIAL
Chia-Chi Wang, Ming-Ta Yang, Kang-Hao Lu, Kuei-Hui Chan
Creatine plays an important role in muscle energy metabolism. Postactivation potentiation (PAP) is a phenomenon that can acutely increase muscle power, but it is an individualized process that is influenced by muscle fatigue. This study examined the effects of creatine supplementation on explosive performance and the optimal individual PAP time during a set of complex training bouts. Thirty explosive athletes performed tests of back squat for one repetition maximum (1RM) strength and complex training bouts for determining the individual optimal timing of PAP, height and peak power of a counter movement jump before and after the supplementation...
March 4, 2016: Nutrients
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