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Lactate AND Substance P

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https://www.readbyqxmd.com/read/27907988/kr12-peptide-associated-with-cyclodextrin-antimicrobial-and-antitumor-activities
#1
Karina I R Teixeira, Maria E Cortés, Robson A S Santos, Flávio Oliveira, Ruben D Sinisterra
The aim of this study was to determine the physical properties and antimicrobial and antiproliferative effects of the KR12 peptide complexed with 2-hydroxypropyl-β-cyclodextrin (Hp-βCd) in vitro. The KR12:Hp-βCd composition was evaluated for particle size and its zeta (ζ)-potential in the presence and absence of cells. Antimicrobial activity against Streptococcus mutans, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis for the peptide alone or associated was evaluated by minimal inhibitory concentration...
December 1, 2016: Biointerphases
https://www.readbyqxmd.com/read/27865413/evaluation-of-chlorhexidine-hydrochloride-treatment-on-endometrial-health-of-normal-mares
#2
Natalie S Fraser, Aime K Johnson, Robyn R Wilborn, Ghislaine A Dujovne, Leland Nuehring
Chlorhexidine gluconate solution is a potent antimicrobial and therefore could be used effectively for treatment of endometritis, but historically this substance has been implicated as irritating to mucous membranes, including the endometrium of the mare. The use of chlorhexidine hydrochloride suspension (Nolvasan Suspension, Zoetis, Florham Park, NJ, USA) was evaluated in the uterus of normal mares to determine if adverse effects on endometrial health were noted. Twelve healthy, adult light breed mares were included in this study...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27819219/effect-of-lysophospholipids-in-diets-differing-in-fat-contents-on-growth-performance-nutrient-digestibility-milk-composition-and-litter-performance-of-lactating-sows
#3
P Y Zhao, Z F Zhang, R X Lan, W C Liu, I H Kim
It is well known that energy plays an important role in sow growth and development. Increasing the utilization of lipids will be beneficial to sows. Emulsifiers are substances which stabilize mixtures and prevent oil and water from separating, thereby enhancing the digestion of lipids. This study was conducted to evaluate the effect of dietary emulsifier (lysophospholipids (LPL)) supplementation in diets differing in fat contents on growth performance, nutrient digestibility and milk composition in lactating sows, as well as performance and fecal score in piglets...
November 7, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27739140/complementarity-of-in-vitro-and-in-vivo-models-for-the-evaluation-of-gastro-protective-effects-of-pharmacological-substances
#4
Sonia Goineau, Vincent Castagné
Gastric mucosa is frequently exposed to various gastric irritants and there is a continuing requirement to develop new gastro-protective agents. The present study compares the effects of three such agents, sucralfate, rebamipide and cimetidine in both in vivo and in vitro indomethacin-induced gastric damage models. For the in vivo approach, rats were orally administered sucralfate, rebamipide and cimetidine at 300 mg/kg before an acute dose of indomethacin (30 mg/kg). Gastric lesions were then macroscopically examined...
October 14, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27723978/development-of-a-hs-spme-gc-ms-ms-method-for-the-quantitation-of-thymol-and-carvacrol-in-bovine-matrices-and-to-determine-residue-depletion-in-milk-and-tissues
#5
Sara Armorini, James E Yeatts, Keena A E Mullen, Sharon E Mason, Elmira Mehmeti, Kevin L Anderson, Steve P Washburn, Ronald E Baynes
Thymol and carvacrol may be present in several phytoceutical products but there are no well-defined methods to measure these compounds in meat and milk from treated animals. U.S. regulatory authorities deem their presence as an adulteration of food. A rapid and sensitive HS-SPME-GC-MS/MS method was developed for the detection of thymol and carvacrol in bovine milk, plasma, liver, kidney, and fat. Inter- and intraday precision values were all less than 15.7 and 20.2% for thymol and carvacrol, respectively. The accuracy was in ranges of 69...
October 11, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27710149/heightened-exercise-induced-oxidative-stress-at-simulated-moderate-level-altitude-vs-sea-level-in-trained-cyclists
#6
Alex J Wadley, Ida S Svendsen, Michael Gleeson
Altitude exposure can exaggerate the transient increase in markers of oxidative stress observed following acute exercise. However, these responses have not been monitored in endurance-trained cyclists at altitudes typically experienced whilst training. Endurance trained males (n=12; mean (±SD) age: 28 ± 4 years, V̇O2max 63.7 ± 5.3 ml/kg/min) undertook two 75-min exercise trials at 70% relative V̇O2max; once in normoxia and once in hypobaric hypoxia, equivalent to 2000m above sea level (hypoxia). Blood samples were collected before, immediately after and 2 h post-exercise to assess plasma parameters of oxidative stress (protein carbonylation (PC), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) and catalase activity (CAT))...
October 6, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27685525/2-deoxy-d-glucose-enhances-dichloroacetate-antitumor-action-against-lewis-lung-carcinoma
#7
O N Pyaskovskaya, D L Kolesnik, A G Fedorchuk, I V Prokhorova, G I Solyanik
UNLABELLED: Aerobic glycolysis that supports high proliferation rate and survival of tumor cells in unfavorable conditions is among fundamental features of tumor metabolism. The search for active modulators of energetic metabolism capable of suppressing tumor growth and metastasis could result in higher effectiveness of anticancer therapy. AIM: To study antitumor and antimetastatic activity of the modulators of energetic metabolism dichloroacetate (DCA) and 2-deoxy-D-glucose (2DG) used in combination treatment of Lewis lung carcinoma (LLC)...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27613672/the-microbial-degradation-of-2-4-6-tribromophenol-tbp-in-water-sediments-interface-investigating-bioaugmentation-using-bacillus-sp-gzt
#8
Jukun Xiong, Guiying Li, Taicheng An
The substance 2,4,6-Tribromophenol (TBP) is used as a flame retardant in electronic and electric devices, and is a replacement for pentachlorophenol in wood preservation. TBP is a contaminant in different environmental matrices, at levels where treatment is required. This study examined the relationship between the bioaugmention of TBP degradation and the evolution of the microbial community in river water/sediment microcosms. When compared with unamended controls, bioaugmentation with Bacillus sp. GZT effectively enhanced TBP biodegradation, with approximately 40...
September 6, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27460135/oxidative-stress-in-dairy-cows-naturally-infected-with-the-lungworm-dictyocaulus-viviparus-nematoda-trichostrongyloidea
#9
A D da Silva, A S da Silva, M D Baldissera, C I Schwertz, N B Bottari, G M Carmo, G Machado, N J Lucca, L C Henker, M M Piva, P Giacomin, V M Morsch, M R C Schetinger, R A da Rosa, R E Mendes
The aim of this study was to analyse the oxidative and anti-oxidant status in serum samples from dairy cows naturally infected by Dictyocaulus viviparus and its relation with pathological analyses. The diagnosis of the disease was confirmed by necropsy of one dairy cow with heavy infection by the parasite in the lungs and bronchi. Later, blood and faeces were collected from another 22 cows from the same farm to measure reactive oxygen species (ROS) levels, thiobarbituric acid-reactive substances (TBARS), catalase (CAT) and superoxide dismutase (SOD) activities on day 0 (pre-treatment) and day 10 (post-treatment with eprinomectin)...
July 27, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/27305761/nanoparticle-based-delivery-of-quercetin-for-the-treatment-of-carbon-tetrachloride-mediated-liver-cirrhosis-in-rats
#10
Shashi Kant Verma, Shweta Rastogil, Indu Arora, Kalim Javed, Mohd Akhtar, Mohd Samim
Liver fibrosis is the common response to chronic liver injury and ultimately leads to cirrhosis. There is a pressing need in the pharmaceutical industry to develop efficient well-targeted drug delivery systems, which are lacking to date. This study was designed to investigate the efficacy of a nanoquercetin NQ; i.e., quercetin encapsulated in PAG (p-aminophenyl-1-thio-β-D-galactopryranoside)-coated NIPAAM (N-isopropyl acrylamide) nanopolymer in liver compared with naked quercetin (Q) using a carbon tetrachloride (CCl₄)-mediated liver cirrhosis model...
February 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/27060822/milk-protein-composition-and-stability-changes-affected-by-iron-in-water-sources
#11
Aili Wang, Susan E Duncan, Katharine F Knowlton, William K Ray, Andrea M Dietrich
Water makes up more than 80% of the total weight of milk. However, the influence of water chemistry on the milk proteome has not been extensively studied. The objective was to evaluate interaction of water-sourced iron (low, medium, and high levels) on milk proteome and implications on milk oxidative state and mineral content. Protein composition, oxidative stability, and mineral composition of milk were investigated under conditions of iron ingestion through bovine drinking water (infused) as well as direct iron addition to commercial milk in 2 studies...
June 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27014811/-effect-of-occupational-exposure-to-toluene-diisocyanate-on-workers-health
#12
Rui Ju, Qiang Jia, Tao Meng, Cuijuan Wang, Xuelei Chen, Yong Niu, Xiao Meng, Xiao Geng, Yinghua Ma, Qixiang Jia, Panpan Miao, Yufei Dai, Yuxin Zheng, Hua Shao
OBJECTIVE: To investigate the effect of occupational exposure to toluene diisocyanate (TDI) on the workers' health. METHODS: A total of 76 workers exposed to TDI (exposure group) and 64 management staff members (control group) were selected from a factory as the study subjects. Area sampling was performed for the place with exposure to TDI according to the method in GBZ 159-2004 Specifications of air sampling for hazardous substances monitoring in the workplace, and gas chromatography was applied to measure the concentration of TDI in workplace air...
January 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27013788/sub-chronic-administration-of-methanolic-whole-fruit-extract-of-lagenaria-breviflora-benth-roberty-induces-mild-toxicity-in-rats
#13
Olubukola Sinbad Olorunnisola, Anthony Jide Afolayan, Adewale Adetutu
BACKGROUND: The effect of the methanolic whole fruit extract from Lagenaria breviflora on vital organs and antioxidant enzymes was investigated in this study. MATERIALS AND METHODS: L. breviflora (250, 500 and 1000 mg/kg/b.w.t./day/rat) was fed orally with the cannula to male albino rats for 28 days. At the end of the treatment, the rats were sacrificed and the effect of the extract on histology of the liver, heart, lipid peroxidation, tissue and serum antioxidant enzymes (superoxide dismutase, catalase, glutathione-s-transferase, glutathione peroxidase) activities, glutathione, myocardial marker enzymes (creatine kinase [CK], lactate dehydrogenase [LDH], alanine transaminase [ALT], and aspartate transaminase [AST]) in serum, and heart homogenate were assessed...
October 2015: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/26998000/anti-diabetic-and-anti-oxidative-activity-of-fixed-oil-extracted-from-ocimum-sanctum-l-leaves-in-diabetic-rats
#14
Thamolwan Suanarunsawat, Gun Anantasomboon, Chutchai Piewbang
Ocimum sanctum L. (OS) leaves have been shown to exert diverse potential benefits in a variety of stress conditions. The present study was conducted to elucidate the effects of the fixed oil extracted from OS leaves on the blood glucose levels and serum lipid profile of streptozotocin-induced diabetic rats. In addition, the anti-oxidative activity of OS leaves to protect various organs including the liver, kidney and heart was investigated. The fixed oil of the OS leaves was extracted using hexane, and the various fatty acid contents of the oil were determined using gas chromatography-mass spectrometry...
March 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26985992/inflammatory-kidney-and-liver-tissue-response-to-different-hydroxyethylstarch-hes-preparations-in-a-rat-model-of-early-sepsis
#15
Ralph C Schimmer, Martin Urner, Stefanie Voigtsberger, Christa Booy, Birgit Roth Z'Graggen, Beatrice Beck-Schimmer, Martin Schläpfer
BACKGROUND: Tissue hypoperfusion and inflammation in sepsis can lead to organ failure including kidney and liver. In sepsis, mortality of acute kidney injury increases by more than 50%. Which type of volume replacement should be used is still an ongoing debate. We investigated the effect of different volume strategies on inflammatory mediators in kidney and liver in an early sepsis model. MATERIAL AND METHODS: Adult male Wistar rats were subjected to sepsis by cecal ligation and puncture (CLP) and assigned to three fluid replenishment groups...
2016: PloS One
https://www.readbyqxmd.com/read/26799427/xanthochromia-of-the-skull-bone-associated-with-hba1c
#16
T Schäfer, M Klintschar, R Lichtinghagen, I Plagemann, A Smith, E Budde, L Hagemeier
The color of the surface of 105 skull bones (part of the parietal bone) was determined using a portable spectral colorimeter (spectro color(®)). By this means it was possible to characterize the color objectively according to the L*a*b* color system defined by the "International Commission de l'Eclairage" (CIE). Biochemical markers of carbohydrate metabolism, HbA1c from venous blood, and glucose/lactate concentrations from vitreous humor, were also determined, for assessment of the ante-mortem plasma glucose concentration using Traub's sum formula...
March 2016: Forensic Science International
https://www.readbyqxmd.com/read/26693858/enhancement-of-high-intensity-actions-and-physical-performance-during-a-simulated-brazilian-jiu-jitsu-competition-with-a-moderate-dose-of-caffeine
#17
Francisco Javier Diaz-Lara, Juan Del Coso, Javier Portillo, Francisco Areces, Jose Manuel García, Javier Abián-Vicén
CONTEXT: Although caffeine is one of the most commonly used substances in combat sports, information about its ergogenic effects on these disciplines is very limited. PURPOSE: To determine the effectiveness of ingesting a moderate dose of caffeine to enhance overall performance during a simulated Brazilian jiu-jitsu (BJJ) competition. METHODS: Fourteen elite BJJ athletes participated in a double-blind, placebo-controlled experimental design...
October 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/26647106/cissampelos-pareira-linn-ameliorates-thyroxin-induced-cardiac-hypertrophy-in-rats
#18
Bhulan Kumar Singh, Krishna Kolappa Pillai, Kanchan Kohli, Syed Ehtaishamul Haque
ETHNOPHARMACOLOGICAL RELEVANCE: Cissampelos pareira extract has been traditionally used in ayruveda as cardiotonic, diuretics and in heart complains but its pharmacological evaluation in thyroxin-induced cardiac hypertrophy has not yet been explored. AIM OF THE STUDY: The aim of this study was to assess the cardioprotective effect of C. pareira root extract in experimentally induced hyperthyroidism in rats. MATERIALS AND METHODS: Male Wistar rats were treated with (i) thyroxin (0...
February 3, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26622220/embelia-ribes-extract-reduces-high-fat-diet-and-low-dose-streptozotocin-induced-diabetic-nephrotoxicity-in-rats
#19
Hemantkumar Somabhai Chaudhari, Uma Bhandari, Geetika Khanna
Nephropathy associated with type 2 diabetes is the single most common cause of end-stage renal disease. The aim of the present study was to evaluate the preventive effect of ethanolic extract of Embelia ribes fruit (EER) against high fat diet (HFD) and low dose streptozotocin (STZ)-induced diabetic nephrotoxicity in Wistar rats. HFD-fed and low dose STZ (35 mg/kg, i.p)-induced diabetic rats were treated with EER (100 and 200 mg/kg/day) for 21 days while continuing on HFD. Preventive effects of EER were demonstrated by significant reduction (p< 0...
2013: EXCLI journal
https://www.readbyqxmd.com/read/26555619/-adequate-fluid-resuscitation-in-septic-shock-with-high-catecholamine-doses
#20
J C Lewejohann, H Braasch, M Hansen, C Zimmermann, E Muhl, T Keck
BACKGROUND: Appropriate fluid resuscitation is a fundamental aspect for the hemodynamic management of septic shock patients and should ideally be achieved before vasopressors and positive inotropic substances are administered. The development of hemodynamic monitoring has revealed that in some cases patients had been improperly treated with high-dose catecholamines for initially insufficient fluid resuscitation. The aim of this study was to show that in some cases it is possible to actively reduce catecholamines by a volume challenge adapted according to the individual patient needs...
September 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
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